TB-Profiler result

Run: ERR4818021
Summary

Run ID: ERR4818021

Sample name:

Date: 2024-10-03T20:06:37.626852

Number of reads: 884841

Percentage reads mapped: 49.99

Median coverage: 28.0

Strain: La1.2.BCG;La1.8.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8 M.bovis None 0.89
La1.8.1 M.bovis None 0.94
La1.2.BCG M.bovis None 0.09
La1 M.bovis None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Leu359Ile Uncertain significance Mutation from literature
p.Tyr384Asn Mutation from literature
p.Ala388Gly Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
embB 4247448 p.His312Arg missense_variant 0.7 ethambutol Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.52 ethambutol Uncertain significance Mutation from literature
embB 4247663 p.Tyr384Asn missense_variant 0.36 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.41 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.47 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.24 isoniazid
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
dnaA 558 c.558G>C synonymous_variant 0.23 isoniazid
dnaA 561 p.His187Gln missense_variant 1.0 isoniazid Uncertain significance
dnaA 567 c.567C>G synonymous_variant 0.24 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.24 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.26 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.25 isoniazid
dnaA 597 c.597C>G synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>A synonymous_variant 0.31 isoniazid
dnaA 612 c.612G>C synonymous_variant 0.42 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.43 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.41 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.37 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.36 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.34 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.32 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.36 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.36 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.34 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.35 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.28 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.29 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.3 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCTC synonymous_variant 0.35 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.36 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.37 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.37 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.38 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.4 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.38 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.39 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.39 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.38 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.38 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.37 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.46 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.45 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.44 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.42 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.33 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.34 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.32 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.32 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.32 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.32 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.29 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.28 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.3 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.29 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.29 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.29 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.31 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.33 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.31 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.31 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.31 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.35 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.33 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.33 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.33 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.33 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.38 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.45 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.43 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.38 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.38 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.36 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.37 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.37 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.32 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.32 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.37 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 0.36 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.36 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.42 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.45 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.45 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.49 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.42 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.39 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.38 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.37 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.37 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.36 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.34 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.33 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.33 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 1332 c.1332A>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.36 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.36 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.26 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.23 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.23 isoniazid
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.4 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6406 c.1167C>T synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 0.9 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6598 c.-704C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.35 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8048 c.747C>A synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.45 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTTG synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 p.Asp367Asn missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.55 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.58 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9080 c.1779G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9217 p.Asp639Ala missense_variant 0.6 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9227 c.1926C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 c.2007C>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9312 c.2011C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9317 c.2016G>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 490812 c.30A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 490815 c.33G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 490827 c.45C>T synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 490848 c.66A>G synonymous_variant 0.41 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 490868 p.Ala29Gly missense_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 490887 c.105G>A synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 490890 c.108C>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 490896 c.114C>T synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 490929 c.147C>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 490935 c.153C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.34 pretomanid
delamanid
clofazimine
fgd1 490962 c.180T>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 490977 c.195C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fgd1 490980 p.Asn66Lys missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 490984 p.Leu68Ile missense_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 490987 p.Leu69Thr missense_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491001 c.219G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491063 p.Gly94Ala missense_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491077 p.Asn99Asp missense_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491082 c.300T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491100 c.318C>T synonymous_variant 0.4 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491106 c.324T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491130 c.348C>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Asp missense_variant 0.49 pretomanid
delamanid
clofazimine
fgd1 491151 c.369G>A synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491173 c.391C>A synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fgd1 491184 c.402A>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 491194 c.412_414delCTAinsTTG synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.54 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.49 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fgd1 491283 p.Asp167Glu missense_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.27 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491601 c.819T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491643 c.861G>A synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491646 c.864G>C synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fgd1 491649 c.867C>T synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fgd1 491658 c.876A>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491661 c.879C>G synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491673 c.891A>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491676 c.894T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491679 c.897A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491687 p.Thr302Lys missense_variant 0.34 pretomanid
delamanid
clofazimine
fgd1 491697 c.915G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 574712 c.-636A>G upstream_gene_variant 0.38 isoniazid
ethionamide
mshA 574718 c.-630A>G upstream_gene_variant 0.36 isoniazid
ethionamide
mshA 574724 c.-624T>C upstream_gene_variant 0.39 isoniazid
ethionamide
mshA 574731 c.-617A>G upstream_gene_variant 0.39 isoniazid
ethionamide
mshA 574739 c.-609T>C upstream_gene_variant 0.41 isoniazid
ethionamide
mshA 575665 c.318G>A synonymous_variant 0.33 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.42 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
ethionamide
mshA 575701 c.354G>A synonymous_variant 0.41 isoniazid
ethionamide
mshA 575704 c.357T>G synonymous_variant 0.38 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.39 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.42 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.43 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.47 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.47 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.44 isoniazid
ethionamide
mshA 575752 c.405G>C synonymous_variant 0.43 isoniazid
ethionamide
mshA 575755 c.408G>A synonymous_variant 0.42 isoniazid
ethionamide
mshA 575756 c.409C>T synonymous_variant 0.42 isoniazid
ethionamide
mshA 575770 c.423G>A synonymous_variant 0.46 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.46 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.49 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.5 isoniazid
ethionamide
mshA 575809 c.462C>T synonymous_variant 0.55 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.54 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.59 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.59 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.6 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.6 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.61 isoniazid Not assoc w R - Interim
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.49 isoniazid
ethionamide
mshA 575887 c.540G>C synonymous_variant 0.49 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.45 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.47 isoniazid
ethionamide
mshA 575908 c.561A>G synonymous_variant 0.5 isoniazid
ethionamide
mshA 575917 p.Asp190Glu missense_variant 0.49 isoniazid
ethionamide
mshA 575920 c.573C>G synonymous_variant 0.49 isoniazid
ethionamide
mshA 575924 p.Gly193Ser missense_variant 0.45 isoniazid
ethionamide
mshA 575944 c.597T>C synonymous_variant 0.41 isoniazid
ethionamide
mshA 575950 c.603C>G synonymous_variant 0.38 isoniazid
ethionamide
mshA 575965 c.618C>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ethionamide
ccsA 619507 c.-384A>G upstream_gene_variant 0.6 kanamycin
capreomycin
amikacin
ccsA 619528 c.-363C>G upstream_gene_variant 0.54 kanamycin
capreomycin
amikacin
ccsA 619531 c.-360T>C upstream_gene_variant 0.54 kanamycin
capreomycin
amikacin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.52 kanamycin
capreomycin
amikacin
ccsA 619543 c.-348C>G upstream_gene_variant 0.52 kanamycin
capreomycin
amikacin
ccsA 619552 c.-339A>G upstream_gene_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 619555 c.-336C>G upstream_gene_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 619561 c.-330G>C upstream_gene_variant 0.53 kanamycin
capreomycin
amikacin
ccsA 619570 c.-321G>C upstream_gene_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 619574 c.-317G>A upstream_gene_variant 0.49 kanamycin
capreomycin
amikacin
ccsA 619579 c.-312G>C upstream_gene_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 619584 c.-307A>T upstream_gene_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 619609 c.-282G>T upstream_gene_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>A upstream_gene_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620226 c.336G>A synonymous_variant 0.48 kanamycin
capreomycin
amikacin
ccsA 620245 c.355T>C synonymous_variant 0.45 kanamycin
capreomycin
amikacin
ccsA 620249 p.Ser120Cys missense_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620254 c.364_366delCTCinsTTG synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620268 c.378G>C synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>T synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.45 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.48 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.43 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620424 c.534G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620433 c.543C>G synonymous_variant 0.37 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.34 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.34 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620460 c.570T>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620461 p.Val191Ile missense_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620625 c.735A>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620631 c.741T>G synonymous_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620646 c.756G>A synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620659 c.769_771delCGCinsAGG synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.34 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.37 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.38 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.38 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620763 c.873G>A synonymous_variant 0.45 kanamycin
capreomycin
amikacin
ccsA 620769 c.879C>G synonymous_variant 0.45 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.32 kanamycin
capreomycin
amikacin
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.23 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.26 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.24 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.26 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.31 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.35 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.42 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.28 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.29 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.29 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.29 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.33 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.33 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.33 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.43 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.53 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.54 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.64 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.52 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.56 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.46 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.4 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.35 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.35 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.32 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.32 isoniazid
hadA 731864 c.-66C>T upstream_gene_variant 0.29 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.41 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.37 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.36 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.38 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.38 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.36 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.31 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.33 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.33 isoniazid
nusG 734111 c.-143A>G upstream_gene_variant 0.29 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.29 rifampicin
nusG 734120 c.-134T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
nusG 734123 c.-131C>G upstream_gene_variant 0.26 rifampicin
nusG 734129 c.-125G>C upstream_gene_variant 0.25 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.25 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.27 rifampicin
nusG 734144 c.-110G>C upstream_gene_variant 0.27 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.26 rifampicin
nusG 734173 c.-81C>G upstream_gene_variant 0.37 rifampicin
nusG 734175 c.-79_-77delGGTinsCTG upstream_gene_variant 0.35 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.35 rifampicin Uncertain significance
nusG 734183 c.-71C>T upstream_gene_variant 0.35 rifampicin
nusG 734186 c.-68G>C upstream_gene_variant 0.35 rifampicin Uncertain significance
nusG 734205 c.-49A>C upstream_gene_variant 0.32 rifampicin
nusG 734329 p.Ala26Thr missense_variant 1.0 rifampicin Uncertain significance
nusG 734407 p.Val52Ile missense_variant 0.32 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.44 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.41 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.47 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.48 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.48 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.53 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.44 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.47 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.35 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.43 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.48 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.39 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.28 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.28 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.26 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.23 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.25 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.5 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.51 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.5 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.65 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.55 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.55 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.59 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.59 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.59 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.59 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.6 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.57 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.47 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.44 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.38 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.49 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.58 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.41 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.41 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.33 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.33 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.35 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.36 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.4 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.36 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.32 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.38 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.39 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.41 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.48 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.54 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.49 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.47 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.52 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.55 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.54 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.51 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.5 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.5 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.46 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.5 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.44 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.39 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.35 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.35 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.39 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.38 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.38 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.37 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.36 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.38 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.36 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.4 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.38 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.49 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.6 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.58 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.6 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.6 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.56 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.57 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.59 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.52 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.53 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.54 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.54 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.51 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.5 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.48 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.47 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.52 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.54 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.54 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.6 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.55 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.57 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.58 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.61 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.61 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.6 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.64 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.64 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.55 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.57 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.55 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.5 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.5 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.44 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.43 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.38 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.38 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.38 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.38 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.37 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.33 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.47 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.46 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.5 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.48 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.41 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.38 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.38 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.33 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.64 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.59 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.59 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.42 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.51 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.51 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.45 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.38 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.34 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.34 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.32 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.4 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.39 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.5 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.65 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.63 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.58 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.59 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.61 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.61 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.6 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.61 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.61 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.62 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.72 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.69 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.67 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.66 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.66 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.64 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.64 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.63 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.57 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.56 rifampicin
rpoC 763942 c.573C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763948 c.579G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763949 c.580C>A synonymous_variant 0.56 rifampicin
rpoC 763954 c.585C>G synonymous_variant 0.56 rifampicin
rpoC 763963 c.594C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.36 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.37 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.31 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.38 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.43 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.46 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.53 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.53 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.52 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.52 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.53 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.53 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.53 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.44 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.36 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.34 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.38 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.37 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.39 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.56 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.59 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.61 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.68 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.68 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.51 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.53 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.47 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.46 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.45 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.55 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.58 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.59 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.52 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.44 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.31 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.33 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.33 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.35 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.47 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.47 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.46 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.52 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.56 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.57 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.58 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.57 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.54 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.55 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.44 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.47 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.49 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.5 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.48 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.48 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.48 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.49 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.57 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.58 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.57 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.54 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.53 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.54 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.55 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.61 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.58 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.51 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.5 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.33 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.23 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766174 p.Asn935Lys missense_variant 0.33 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.28 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.25 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.28 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.32 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.33 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.37 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.38 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.4 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.45 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.47 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.53 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.54 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.55 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.53 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.43 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.37 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.32 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.31 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.34 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.38 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.41 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.4 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.37 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.36 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.36 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.37 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.38 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.41 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.43 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.53 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.58 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.62 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.62 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.59 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.59 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.67 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.67 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.64 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.57 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.57 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.58 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.56 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.57 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.66 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.56 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.48 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.47 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.44 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.41 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.57 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.58 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.47 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767265 p.Ala1299Glu missense_variant 0.21 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775975 c.2506T>C synonymous_variant 0.25 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.28 bedaquiline
clofazimine
mmpL5 775991 c.2490G>A synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 776002 p.Leu827Met missense_variant 0.21 bedaquiline
clofazimine
mmpL5 776005 p.Ile826Leu missense_variant 0.22 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.33 bedaquiline
clofazimine
mmpL5 776030 c.2451G>A synonymous_variant 0.34 bedaquiline
clofazimine
mmpL5 776053 c.2428T>C synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776056 p.Val809Leu missense_variant 0.24 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 777133 p.Val450Ile missense_variant 0.27 bedaquiline
clofazimine
mmpL5 777158 c.1323C>G synonymous_variant 0.33 bedaquiline
clofazimine
mmpL5 777164 c.1317C>G synonymous_variant 0.32 bedaquiline
clofazimine
mmpL5 777170 c.1311T>C synonymous_variant 0.35 bedaquiline
clofazimine
mmpL5 777176 p.Glu435Asp missense_variant 0.35 bedaquiline
clofazimine
mmpL5 777191 c.1290C>G synonymous_variant 0.36 bedaquiline
clofazimine
mmpL5 777194 c.1287A>G synonymous_variant 0.36 bedaquiline
clofazimine
mmpL5 777206 c.1275A>G synonymous_variant 0.33 bedaquiline
clofazimine
mmpL5 777212 p.Ala423Thr missense_variant 0.32 bedaquiline
clofazimine
mmpL5 777215 c.1266C>G synonymous_variant 0.33 bedaquiline
clofazimine
mmpL5 777218 c.1263G>A synonymous_variant 0.33 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.32 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.36 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.43 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.43 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.47 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.47 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.46 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.5 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.51 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.54 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.57 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.59 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.62 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.64 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.7 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.72 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.69 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.71 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.69 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.69 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.67 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.65 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.66 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.67 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.61 streptomycin Uncertain significance
rplC 800648 c.-161A>T upstream_gene_variant 0.35 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.32 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.28 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.27 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.31 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.3 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.29 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.36 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.39 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.39 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.4 linezolid
rplC 800814 c.6A>G synonymous_variant 0.39 linezolid
rplC 800817 c.9A>T synonymous_variant 0.37 linezolid
rplC 801195 c.387G>C synonymous_variant 0.32 linezolid
rplC 801207 c.399C>T synonymous_variant 0.29 linezolid
rplC 801246 c.438C>T synonymous_variant 0.41 linezolid
rplC 801249 c.441T>C synonymous_variant 0.42 linezolid
rplC 801255 c.447C>T synonymous_variant 0.43 linezolid
rplC 801264 c.456C>T synonymous_variant 0.35 linezolid
rplC 801267 c.459A>T synonymous_variant 0.34 linezolid
rplC 801270 c.462T>C synonymous_variant 0.33 linezolid
rplC 801276 c.468G>C synonymous_variant 0.4 linezolid
rplC 801279 c.471G>C synonymous_variant 0.4 linezolid
rplC 801282 c.474G>C synonymous_variant 0.4 linezolid
rplC 801285 c.477G>C synonymous_variant 0.41 linezolid
rplC 801300 c.492C>G synonymous_variant 0.47 linezolid
rplC 801309 c.501C>G synonymous_variant 0.47 linezolid
rplC 801312 c.504G>C synonymous_variant 0.46 linezolid
rplC 801321 c.513C>T synonymous_variant 0.42 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.45 linezolid
rplC 801339 c.531T>C synonymous_variant 0.36 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.36 linezolid
rplC 801348 c.540T>G synonymous_variant 0.37 linezolid
rplC 801357 c.549T>C synonymous_variant 0.38 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.36 linezolid
rplC 801402 c.594T>C synonymous_variant 0.44 linezolid
rplC 801405 c.597T>C synonymous_variant 0.41 linezolid
rplC 801423 c.615G>C synonymous_variant 0.48 linezolid
rplC 801426 c.618C>G synonymous_variant 0.48 linezolid
rplC 801427 p.Met207Val missense_variant 0.52 linezolid
rplC 801438 c.630T>C synonymous_variant 0.51 linezolid
rplC 801442 p.Ile212Val missense_variant 0.51 linezolid
rplC 801454 p.Glu216Gln missense_variant 0.53 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiC 1303489 c.559C>T synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303497 c.567G>A synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303501 c.571C>T synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303509 c.579G>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1303521 c.591C>T synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1303530 c.600G>A synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303539 c.609G>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303671 c.741C>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1303674 c.744C>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303681 c.751T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.45 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303944 c.1014G>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303953 p.Asp341Glu missense_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1303956 c.1026A>G synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1303971 c.1041T>C synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>A synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1303998 c.1068T>G synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304004 c.1074A>G synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304022 c.1092T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304031 c.1101C>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304034 c.1104A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304040 c.1110C>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304046 c.1116C>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304049 c.1119T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304050 c.1120T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304058 c.1128G>A synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304059 c.1129C>T synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304064 c.1134G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304067 c.1137G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304085 c.1155C>T synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304091 p.Asp387Glu missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304092 p.Met388Leu missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304097 c.1167G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304106 c.1176G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304127 c.1197A>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304142 c.1212G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304161 p.Arg411Ser missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304169 c.1239T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304174 p.Val415Ala missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304184 c.1254G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304187 c.1257T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304208 c.1278C>T synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304499 c.1569T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304511 c.1581C>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304535 c.1605G>A synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>T synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.47 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304739 c.1809C>T synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.66 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.84 pretomanid
delamanid
clofazimine
fbiC 1304862 c.1932G>A synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1305252 c.2322G>A synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1305276 c.2346G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305279 p.His783Gln missense_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305282 c.2352T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305297 c.2367G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305300 c.2370A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305303 c.2373T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305306 c.2376A>T synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305309 c.2379G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305310 p.Arg794Glu missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305318 c.2388C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305331 p.Glu801Asn missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305336 c.2406T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305372 c.2442G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305384 c.2454G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461132 p.Val30Ile missense_variant 0.36 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.33 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.33 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.31 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.3 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.26 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.25 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.26 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.26 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471935 n.90T>C non_coding_transcript_exon_variant 0.77 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
inhA 1673633 c.-569G>A upstream_gene_variant 0.41 isoniazid
ethionamide
inhA 1673637 c.-565C>G upstream_gene_variant 0.41 isoniazid
ethionamide
inhA 1673641 c.-561G>A upstream_gene_variant 0.39 isoniazid
ethionamide
inhA 1673715 c.-487C>G upstream_gene_variant 0.65 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673748 c.-454A>G upstream_gene_variant 0.43 isoniazid
ethionamide
inhA 1673749 c.-453_-452delAAinsCG upstream_gene_variant 0.43 isoniazid
ethionamide
inhA 1673758 c.-444A>G upstream_gene_variant 0.47 isoniazid
ethionamide
inhA 1673941 c.-261G>T upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.55 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.57 isoniazid
ethionamide
inhA 1673985 c.-217C>G upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.57 isoniazid
ethionamide
inhA 1674015 c.-187C>T upstream_gene_variant 0.5 isoniazid Uncertain significance
ethionamide
inhA 1674018 c.-184G>C upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1674021 c.-181G>C upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1674024 c.-178T>C upstream_gene_variant 0.45 isoniazid
ethionamide
inhA 1674033 c.-169T>C upstream_gene_variant 0.45 isoniazid
ethionamide
inhA 1674037 c.-165_-164delCAinsGC upstream_gene_variant 0.43 isoniazid
ethionamide
inhA 1674042 c.-160G>T upstream_gene_variant 0.47 isoniazid
ethionamide
inhA 1674049 c.-153_-151delCAAinsGAC upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1674054 c.-148T>C upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1674060 c.-142A>G upstream_gene_variant 0.56 isoniazid
ethionamide
inhA 1674063 c.-139G>C upstream_gene_variant 0.53 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674504 c.303C>G synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.44 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.39 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.42 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.5 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.43 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674672 c.471C>G synonymous_variant 0.46 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.55 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674741 c.540C>T synonymous_variant 0.33 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674746 p.Tyr182Phe missense_variant 0.3 isoniazid
ethionamide
inhA 1674750 c.549T>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674753 c.552G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674789 c.588G>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.37 isoniazid
ethionamide
inhA 1674816 c.615T>C synonymous_variant 0.33 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674822 c.621C>G synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674828 c.627G>A synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.38 isoniazid
ethionamide
inhA 1674864 c.663C>T synonymous_variant 0.39 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674888 c.687C>G synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.41 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.32 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.45 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.49 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.48 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.49 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.44 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.44 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.51 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.43 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.48 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.43 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.42 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.49 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.57 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.49 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.47 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.47 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.44 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.43 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 0.75 pyrazinamide Uncertain significance
tsnR 1853361 c.-245T>C upstream_gene_variant 0.54 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.55 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.62 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.62 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.71 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.71 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.69 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.68 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.66 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.58 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.6 linezolid
tsnR 1853468 c.-138C>G upstream_gene_variant 0.59 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.63 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.63 linezolid
tsnR 1853484 c.-122_-120delAGCinsGCG upstream_gene_variant 0.62 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.62 linezolid
tsnR 1853498 c.-108G>C upstream_gene_variant 0.64 linezolid
tsnR 1853517 c.-89G>A upstream_gene_variant 0.57 linezolid
tsnR 1853525 c.-81G>C upstream_gene_variant 0.53 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917908 c.-32C>G upstream_gene_variant 0.23 capreomycin
tlyA 1917929 c.-11T>C upstream_gene_variant 0.29 capreomycin
tlyA 1917937 c.-3_-2insC upstream_gene_variant 0.3 capreomycin
tlyA 1917940 p.Val1Met missense_variant 0.29 capreomycin
tlyA 1917943 p.Ala2Ser missense_variant 0.27 capreomycin
tlyA 1917951 c.12T>C synonymous_variant 0.32 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.46 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.48 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.55 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.55 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.55 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.57 capreomycin
tlyA 1918036 p.Arg33Ser missense_variant 0.67 capreomycin
tlyA 1918048 p.Leu37Met missense_variant 0.64 capreomycin
tlyA 1918053 c.114G>C synonymous_variant 0.54 capreomycin
tlyA 1918057 p.Val40Arg missense_variant 0.52 capreomycin
tlyA 1918065 c.126G>C synonymous_variant 0.43 capreomycin
tlyA 1918067 p.Ala43Gly missense_variant 0.42 capreomycin
tlyA 1918077 c.138G>C synonymous_variant 0.4 capreomycin
tlyA 1918078 p.Ser47Ala missense_variant 0.4 capreomycin
tlyA 1918082 p.Asp48Val missense_variant 0.4 capreomycin
tlyA 1918087 p.Thr50Ala missense_variant 0.4 capreomycin
tlyA 1918092 c.153G>C synonymous_variant 0.41 capreomycin
tlyA 1918103 p.Val55Ala missense_variant 0.37 capreomycin
tlyA 1918137 c.198A>C synonymous_variant 0.3 capreomycin
tlyA 1918197 c.258T>C synonymous_variant 0.38 capreomycin
tlyA 1918206 c.267G>C synonymous_variant 0.36 capreomycin
tlyA 1918212 c.273A>G synonymous_variant 0.35 capreomycin
tlyA 1918218 c.279C>G synonymous_variant 0.33 capreomycin
tlyA 1918221 c.282T>C synonymous_variant 0.31 capreomycin
tlyA 1918224 c.285G>C synonymous_variant 0.31 capreomycin
tlyA 1918236 c.297A>C synonymous_variant 0.42 capreomycin
tlyA 1918248 c.309T>C synonymous_variant 0.38 capreomycin
tlyA 1918251 c.312T>G synonymous_variant 0.39 capreomycin
tlyA 1918258 p.His107Glu missense_variant 0.42 capreomycin
tlyA 1918271 p.Ala111Val missense_variant 0.32 capreomycin
tlyA 1918275 c.336T>C synonymous_variant 0.29 capreomycin
tlyA 1918278 c.339C>G synonymous_variant 0.3 capreomycin
tlyA 1918310 p.Asn124Ser missense_variant 0.4 capreomycin
tlyA 1918315 p.Pro126Ala missense_variant 0.4 capreomycin
tlyA 1918323 c.384G>C synonymous_variant 0.38 capreomycin
tlyA 1918326 c.387G>C synonymous_variant 0.36 capreomycin
tlyA 1918330 p.Leu131Val missense_variant 0.35 capreomycin
tlyA 1918346 p.Ala136Val missense_variant 0.31 capreomycin
tlyA 1918352 p.Gly138Asp missense_variant 0.29 capreomycin
tlyA 1918356 c.417C>G synonymous_variant 0.3 capreomycin
tlyA 1918359 c.420A>G synonymous_variant 0.29 capreomycin
tlyA 1918362 c.423G>C synonymous_variant 0.32 capreomycin
bacA 2063157 c.1572C>G synonymous_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101783 c.1260T>G synonymous_variant 0.44 isoniazid
delamanid
ethionamide
ndh 2101804 c.1239T>G synonymous_variant 0.62 isoniazid
delamanid
ethionamide
ndh 2101808 p.Thr412Ser missense_variant 0.62 isoniazid
delamanid
ethionamide
ndh 2101830 p.Ile405Val missense_variant 0.64 isoniazid
delamanid
ethionamide
ndh 2101837 p.Ala402Val missense_variant 0.62 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
ndh 2101858 p.LeuIle394PheAla missense_variant 0.55 isoniazid
delamanid
ethionamide
ndh 2101872 p.Ile391Phe missense_variant 0.58 isoniazid
delamanid
ethionamide
ndh 2101873 p.Phe390Leu missense_variant 0.58 isoniazid
delamanid
ethionamide
ndh 2101885 c.1158G>A synonymous_variant 0.59 isoniazid
delamanid
ethionamide
ndh 2101888 c.1155T>C synonymous_variant 0.59 isoniazid
delamanid
ethionamide
ndh 2101894 c.1149T>G synonymous_variant 0.62 isoniazid
delamanid
ethionamide
ndh 2101912 c.1131G>C synonymous_variant 0.66 isoniazid
delamanid
ethionamide
ndh 2101920 c.1123A>C synonymous_variant 0.7 isoniazid
delamanid
ethionamide
ndh 2101924 c.1119T>G synonymous_variant 0.7 isoniazid
delamanid
ethionamide
ndh 2101939 c.1104A>G synonymous_variant 0.62 isoniazid
delamanid
ethionamide
ndh 2101960 c.1083A>G synonymous_variant 0.57 isoniazid
delamanid
ethionamide
ndh 2101988 p.Ala352Asp missense_variant 0.52 isoniazid
delamanid
ethionamide
ndh 2101990 c.1053G>C synonymous_variant 0.52 isoniazid
delamanid
ethionamide
ndh 2101993 c.1050A>G synonymous_variant 0.52 isoniazid
delamanid
ethionamide
ndh 2103173 c.-132delG upstream_gene_variant 1.0 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2155691 c.421T>C synonymous_variant 0.28 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.29 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.3 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.28 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.28 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.26 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.24 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.24 isoniazid
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.59 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.41 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.41 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.34 isoniazid
kasA 2518121 p.Gln3Lys missense_variant 0.32 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.45 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.29 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.29 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.36 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.36 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.35 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.35 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.33 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.39 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.45 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.35 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.34 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.34 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.33 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.36 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.38 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.38 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.42 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.43 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.45 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.48 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.6 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.62 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.61 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.59 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.61 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.62 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.6 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.62 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.64 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.66 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.67 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.67 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.67 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.63 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.6 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.59 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.58 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.55 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.51 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.47 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.44 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.47 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.47 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.53 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.5 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.47 isoniazid
kasA 2518927 c.813C>G synonymous_variant 0.45 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.47 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.45 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.48 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.58 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.58 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.57 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.54 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.52 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.48 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.47 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.45 isoniazid
kasA 2518999 c.885G>A synonymous_variant 0.45 isoniazid
kasA 2519008 c.894C>G synonymous_variant 0.47 isoniazid
kasA 2519017 c.903G>C synonymous_variant 0.47 isoniazid
kasA 2519020 c.906G>C synonymous_variant 0.47 isoniazid
kasA 2519021 p.Ala303Lys missense_variant 0.47 isoniazid
kasA 2519027 p.Ile305Val missense_variant 0.48 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.5 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.46 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.49 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.53 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.51 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.43 isoniazid
kasA 2519108 p.Asp332Gln missense_variant 0.43 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.45 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.43 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.39 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.39 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.38 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.24 isoniazid
eis 2715125 p.Thr70Ala missense_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
folC 2747355 p.Val82Ile missense_variant 0.45 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.43 para-aminosalicylic_acid
Rv2477c 2782807 p.Tyr412His missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782816 c.1227T>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782822 c.1221G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782828 c.1215T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.35 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.51 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.53 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.56 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.51 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.5 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.47 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin