TB-Profiler

TB-Profiler result

Run: SRR1640750

Summary

Run ID: SRR1640750

Sample name:

Date: 2024-05-22T14:35:24.634631

Number of reads: 911268

Percentage reads mapped: 57.8

Median coverage: 37.0

Strain:

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage4.1.2	Euro-American	None	0.98

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin	rpoB	c.1327_1329delTTGinsCC	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol	embB	p.His312Arg		Mutation from literature
ethambutol	embB	p.Ala388Gly		Mutation from literature
pyrazinamide
streptomycin	rrs	n.462C>T	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid	fgd1	c.202_204delCTGinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
delamanid	fgd1	c.301_303delGTTinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	c.550_552delCAAinsGG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	c.859_861delATCinsGG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.1948_1950delCGCinsAG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
fgd1	490984	c.202_204delCTGinsAC	frameshift_variant&missense_variant	0.52	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fgd1	490984	c.202_204delCTGinsAC	frameshift_variant&missense_variant	0.52	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fgd1	491083	c.301_303delGTTinsAC	frameshift_variant&missense_variant	0.57	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fgd1	491083	c.301_303delGTTinsAC	frameshift_variant&missense_variant	0.57	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rpoB	761133	c.1327_1329delTTGinsCC	frameshift_variant&missense_variant	0.8	rifampicin	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
fbiC	1303480	c.550_552delCAAinsGG	frameshift_variant&missense_variant	0.31	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303480	c.550_552delCAAinsGG	frameshift_variant&missense_variant	0.31	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303789	c.859_861delATCinsGG	frameshift_variant&missense_variant	0.51	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303789	c.859_861delATCinsGG	frameshift_variant&missense_variant	0.51	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303969	c.1039_1041delGTTinsAC	frameshift_variant&missense_variant	0.61	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303969	c.1039_1041delGTTinsAC	frameshift_variant&missense_variant	0.61	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1304878	c.1948_1950delCGCinsAG	frameshift_variant&missense_variant	0.45	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1304878	c.1948_1950delCGCinsAG	frameshift_variant&missense_variant	0.45	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	0.42	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	0.42	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	0.55	streptomycin	Uncertain significance	Mutation from literature
embB	4247448	p.His312Arg	missense_variant	0.73	ethambutol		Mutation from literature
embB	4247676	p.Ala388Gly	missense_variant	0.41	ethambutol		Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	522	c.522T>C	synonymous_variant	0.45	isoniazid	Not assoc w R - Interim
dnaA	525	c.525T>C	synonymous_variant	0.48	isoniazid
dnaA	534	c.534T>G	synonymous_variant	0.5	isoniazid
dnaA	540	c.540C>G	synonymous_variant	0.49	isoniazid
dnaA	543	c.543C>G	synonymous_variant	0.49	isoniazid
dnaA	571	c.571T>C	synonymous_variant	0.54	isoniazid
dnaA	576	c.576G>C	synonymous_variant	0.54	isoniazid
dnaA	582	c.582A>C	synonymous_variant	0.54	isoniazid	Not assoc w R - Interim
dnaA	591	c.591C>G	synonymous_variant	0.56	isoniazid
dnaA	600	c.600T>C	synonymous_variant	0.53	isoniazid
dnaA	609	c.609C>G	synonymous_variant	0.52	isoniazid
dnaA	610	c.610C>T	synonymous_variant	0.52	isoniazid
dnaA	636	c.636C>G	synonymous_variant	0.5	isoniazid
dnaA	645	c.645A>G	synonymous_variant	0.51	isoniazid	Not assoc w R - Interim
dnaA	654	c.654A>G	synonymous_variant	0.5	isoniazid
dnaA	660	c.660G>C	synonymous_variant	0.51	isoniazid	Not assoc w R - Interim
dnaA	663	c.663A>C	synonymous_variant	0.53	isoniazid
dnaA	669	c.669C>T	synonymous_variant	0.5	isoniazid
dnaA	672	c.672T>C	synonymous_variant	0.5	isoniazid	Not assoc w R - Interim
dnaA	675	c.675C>G	synonymous_variant	0.5	isoniazid	Not assoc w R - Interim
dnaA	678	c.678A>G	synonymous_variant	0.53	isoniazid	Not assoc w R - Interim
dnaA	682	c.682_684delTTGinsCC	frameshift_variant&missense_variant	0.54	isoniazid	Uncertain significance
dnaA	690	c.690G>C	synonymous_variant	0.57	isoniazid
dnaA	693	c.693A>C	synonymous_variant	0.57	isoniazid
dnaA	705	c.705A>G	synonymous_variant	0.59	isoniazid
dnaA	708	c.708T>C	synonymous_variant	0.63	isoniazid
dnaA	741	c.741T>C	synonymous_variant	0.66	isoniazid	Not assoc w R - Interim
dnaA	750	c.750C>G	synonymous_variant	0.68	isoniazid
dnaA	756	c.756T>C	synonymous_variant	0.7	isoniazid
dnaA	771	c.771A>C	synonymous_variant	0.65	isoniazid
dnaA	777	c.777A>G	synonymous_variant	0.65	isoniazid
dnaA	786	c.786C>T	synonymous_variant	0.62	isoniazid
dnaA	795	c.795A>C	synonymous_variant	0.62	isoniazid	Not assoc w R - Interim
dnaA	805	c.805T>C	synonymous_variant	0.59	isoniazid
dnaA	813	c.813C>T	synonymous_variant	0.57	isoniazid
dnaA	822	c.822A>G	synonymous_variant	0.57	isoniazid
dnaA	828	c.828T>C	synonymous_variant	0.54	isoniazid	Not assoc w R - Interim
dnaA	831	c.831A>G	synonymous_variant	0.54	isoniazid
dnaA	837	c.837A>G	synonymous_variant	0.52	isoniazid
dnaA	840	c.840G>A	synonymous_variant	0.52	isoniazid
dnaA	843	c.843T>C	synonymous_variant	0.52	isoniazid	Not assoc w R - Interim
dnaA	846	c.846T>C	synonymous_variant	0.54	isoniazid
dnaA	849	c.849A>G	synonymous_variant	0.56	isoniazid
dnaA	876	c.876C>G	synonymous_variant	0.56	isoniazid
dnaA	877	c.877T>C	synonymous_variant	0.56	isoniazid
dnaA	885	c.885T>C	synonymous_variant	0.53	isoniazid
dnaA	897	c.897A>G	synonymous_variant	0.55	isoniazid
dnaA	909	c.909A>C	synonymous_variant	0.55	isoniazid	Not assoc w R - Interim
dnaA	912	c.912T>C	synonymous_variant	0.55	isoniazid
dnaA	918	c.918C>G	synonymous_variant	0.55	isoniazid
dnaA	921	c.921A>G	synonymous_variant	0.55	isoniazid	Not assoc w R - Interim
dnaA	927	c.927G>A	synonymous_variant	0.57	isoniazid
dnaA	933	c.933C>G	synonymous_variant	0.57	isoniazid
dnaA	942	c.942C>G	synonymous_variant	0.52	isoniazid
dnaA	945	c.945G>A	synonymous_variant	0.52	isoniazid
dnaA	955	c.955A>C	synonymous_variant	0.5	isoniazid
dnaA	963	c.963C>G	synonymous_variant	0.48	isoniazid
dnaA	966	c.966T>C	synonymous_variant	0.48	isoniazid
dnaA	975	c.975G>C	synonymous_variant	0.52	isoniazid
dnaA	984	c.984T>C	synonymous_variant	0.46	isoniazid	Not assoc w R - Interim
dnaA	990	c.990A>G	synonymous_variant	0.43	isoniazid	Not assoc w R - Interim
dnaA	993	c.993A>G	synonymous_variant	0.38	isoniazid
dnaA	996	c.996A>C	synonymous_variant	0.38	isoniazid	Not assoc w R - Interim
dnaA	1002	c.1002G>A	synonymous_variant	0.41	isoniazid
dnaA	1005	c.1005G>C	synonymous_variant	0.41	isoniazid
dnaA	1008	c.1008G>A	synonymous_variant	0.43	isoniazid	Not assoc w R - Interim
dnaA	1020	c.1020C>G	synonymous_variant	0.44	isoniazid
dnaA	1024	c.1024T>C	synonymous_variant	0.43	isoniazid
dnaA	1035	c.1035A>G	synonymous_variant	0.5	isoniazid
dnaA	1047	c.1047A>G	synonymous_variant	0.47	isoniazid
dnaA	1050	c.1050G>C	synonymous_variant	0.47	isoniazid
dnaA	1053	c.1053C>G	synonymous_variant	0.48	isoniazid	Not assoc w R - Interim
dnaA	1059	c.1059C>G	synonymous_variant	0.45	isoniazid
dnaA	1068	c.1068T>C	synonymous_variant	0.45	isoniazid
dnaA	1071	c.1071C>G	synonymous_variant	0.45	isoniazid
dnaA	1074	c.1074C>G	synonymous_variant	0.45	isoniazid
dnaA	1092	c.1092T>C	synonymous_variant	0.54	isoniazid	Not assoc w R - Interim
dnaA	1098	c.1098A>G	synonymous_variant	0.53	isoniazid
dnaA	1104	c.1104T>C	synonymous_variant	0.53	isoniazid
dnaA	1110	c.1110T>C	synonymous_variant	0.53	isoniazid
dnaA	1125	c.1125G>C	synonymous_variant	0.53	isoniazid
dnaA	1152	c.1152A>G	synonymous_variant	0.59	isoniazid
dnaA	1153	c.1153T>C	synonymous_variant	0.58	isoniazid
dnaA	1161	c.1161A>G	synonymous_variant	0.58	isoniazid
dnaA	1164	c.1164A>T	synonymous_variant	0.59	isoniazid
dnaA	1167	c.1167A>G	synonymous_variant	0.56	isoniazid	Not assoc w R - Interim
dnaA	1176	c.1176A>G	synonymous_variant	0.53	isoniazid
dnaA	1177	p.Ala393Ser	missense_variant	0.54	isoniazid
dnaA	1191	c.1191T>C	synonymous_variant	0.57	isoniazid
dnaA	1197	c.1197T>G	synonymous_variant	0.58	isoniazid
dnaA	1204	c.1204C>T	synonymous_variant	0.59	isoniazid
dnaA	1220	p.Asn407Ser	missense_variant	0.6	isoniazid
dnaA	1230	c.1230A>G	synonymous_variant	0.6	isoniazid
dnaA	1242	c.1242G>C	synonymous_variant	0.65	isoniazid
dnaA	1245	c.1245G>C	synonymous_variant	0.68	isoniazid	Not assoc w R - Interim
dnaA	1254	c.1254T>C	synonymous_variant	0.65	isoniazid
dnaA	1278	c.1278T>C	synonymous_variant	0.63	isoniazid
dnaA	1287	c.1287A>G	synonymous_variant	0.58	isoniazid
dnaA	1290	c.1290G>A	synonymous_variant	0.58	isoniazid
dnaA	1293	c.1293T>G	synonymous_variant	0.58	isoniazid
dnaA	1302	c.1302C>G	synonymous_variant	0.61	isoniazid
dnaA	1314	c.1314A>G	synonymous_variant	0.58	isoniazid
dnaA	1317	c.1317A>G	synonymous_variant	0.58	isoniazid
dnaA	1329	c.1329A>C	synonymous_variant	0.57	isoniazid
dnaA	1332	c.1332A>T	synonymous_variant	0.55	isoniazid
dnaA	1335	c.1335G>A	synonymous_variant	0.55	isoniazid
dnaA	1338	c.1338T>C	synonymous_variant	0.55	isoniazid
dnaA	1353	c.1353T>C	synonymous_variant	0.55	isoniazid
dnaA	1356	c.1356T>C	synonymous_variant	0.55	isoniazid	Not assoc w R - Interim
dnaA	1365	c.1365C>G	synonymous_variant	0.56	isoniazid
dnaA	1371	c.1371T>G	synonymous_variant	0.53	isoniazid
dnaA	1375	c.1375T>C	synonymous_variant	0.54	isoniazid
dnaA	1383	c.1383A>G	synonymous_variant	0.51	isoniazid
dnaA	1389	c.1389C>G	synonymous_variant	0.49	isoniazid
dnaA	1392	c.1392A>G	synonymous_variant	0.46	isoniazid
dnaA	1395	c.1395G>C	synonymous_variant	0.45	isoniazid
dnaA	1404	c.1404T>C	synonymous_variant	0.45	isoniazid
dnaA	1407	c.1407T>C	synonymous_variant	0.45	isoniazid
dnaA	1413	c.1413A>C	synonymous_variant	0.45	isoniazid
dnaA	1416	c.1416C>G	synonymous_variant	0.43	isoniazid
dnaA	1419	c.1419C>G	synonymous_variant	0.43	isoniazid
dnaA	1431	c.1431A>G	synonymous_variant	0.37	isoniazid
dnaA	1461	c.1461C>A	synonymous_variant	0.29	isoniazid
dnaA	1464	c.1464T>C	synonymous_variant	0.29	isoniazid
dnaA	1470	c.1470C>G	synonymous_variant	0.26	isoniazid
dnaA	1473	c.1473T>C	synonymous_variant	0.24	isoniazid	Not assoc w R - Interim
gyrB	6169	c.930C>G	synonymous_variant	0.3	levofloxacin
gyrB	6169	c.930C>G	synonymous_variant	0.3	moxifloxacin
gyrB	6190	c.951A>G	synonymous_variant	0.41	levofloxacin
gyrB	6190	c.951A>G	synonymous_variant	0.41	moxifloxacin
gyrB	6209	c.970C>T	synonymous_variant	0.47	levofloxacin
gyrB	6209	c.970C>T	synonymous_variant	0.47	moxifloxacin
gyrB	6214	c.975G>C	synonymous_variant	0.47	levofloxacin
gyrB	6214	c.975G>C	synonymous_variant	0.47	moxifloxacin
gyrB	6217	c.978G>C	synonymous_variant	0.52	levofloxacin
gyrB	6217	c.978G>C	synonymous_variant	0.52	moxifloxacin
gyrB	6223	c.984G>C	synonymous_variant	0.52	levofloxacin	Not assoc w R - Interim
gyrB	6223	c.984G>C	synonymous_variant	0.52	moxifloxacin	Not assoc w R - Interim
gyrB	6242	p.Arg335Lys	missense_variant	0.56	levofloxacin
gyrB	6242	p.Arg335Lys	missense_variant	0.56	moxifloxacin
gyrB	6250	c.1011A>G	synonymous_variant	0.58	levofloxacin	Not assoc w R - Interim
gyrB	6250	c.1011A>G	synonymous_variant	0.58	moxifloxacin	Not assoc w R - Interim
gyrB	6253	c.1014G>C	synonymous_variant	0.58	levofloxacin
gyrB	6253	c.1014G>C	synonymous_variant	0.58	moxifloxacin
gyrB	6280	c.1041T>C	synonymous_variant	0.58	levofloxacin
gyrB	6280	c.1041T>C	synonymous_variant	0.58	moxifloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.58	levofloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.58	moxifloxacin
gyrB	6292	c.1053G>C	synonymous_variant	0.58	levofloxacin
gyrB	6292	c.1053G>C	synonymous_variant	0.58	moxifloxacin
gyrB	6295	c.1056A>G	synonymous_variant	0.58	levofloxacin
gyrB	6295	c.1056A>G	synonymous_variant	0.58	moxifloxacin
gyrB	6298	c.1059C>T	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrB	6298	c.1059C>T	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrB	6299	c.1060C>T	synonymous_variant	0.58	levofloxacin
gyrB	6299	c.1060C>T	synonymous_variant	0.58	moxifloxacin
gyrB	6307	c.1068T>G	synonymous_variant	0.58	levofloxacin	Not assoc w R - Interim
gyrB	6307	c.1068T>G	synonymous_variant	0.58	moxifloxacin	Not assoc w R - Interim
gyrB	6319	c.1080G>C	synonymous_variant	0.58	levofloxacin	Not assoc w R - Interim
gyrB	6319	c.1080G>C	synonymous_variant	0.58	moxifloxacin
gyrA	6325	c.-977C>G	upstream_gene_variant	0.58	levofloxacin
gyrA	6325	c.-977C>G	upstream_gene_variant	0.58	moxifloxacin
gyrA	6361	c.-941G>A	upstream_gene_variant	0.58	levofloxacin
gyrA	6361	c.-941G>A	upstream_gene_variant	0.58	moxifloxacin
gyrA	6362	c.-940T>C	upstream_gene_variant	0.58	levofloxacin
gyrA	6362	c.-940T>C	upstream_gene_variant	0.58	moxifloxacin
gyrA	6379	c.-923C>G	upstream_gene_variant	0.59	levofloxacin
gyrA	6379	c.-923C>G	upstream_gene_variant	0.59	moxifloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.57	levofloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.57	moxifloxacin
gyrA	6388	c.-914T>C	upstream_gene_variant	0.6	levofloxacin
gyrA	6388	c.-914T>C	upstream_gene_variant	0.6	moxifloxacin
gyrA	6400	c.-902C>G	upstream_gene_variant	0.5	levofloxacin
gyrA	6400	c.-902C>G	upstream_gene_variant	0.5	moxifloxacin
gyrA	6403	c.-899T>C	upstream_gene_variant	0.5	levofloxacin
gyrA	6403	c.-899T>C	upstream_gene_variant	0.5	moxifloxacin
gyrA	6415	c.-887G>C	upstream_gene_variant	0.47	levofloxacin
gyrA	6415	c.-887G>C	upstream_gene_variant	0.47	moxifloxacin
gyrA	6670	c.-632G>C	upstream_gene_variant	0.53	levofloxacin
gyrA	6670	c.-632G>C	upstream_gene_variant	0.53	moxifloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	0.62	levofloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	0.62	moxifloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.59	levofloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.59	moxifloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.59	levofloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.59	moxifloxacin
gyrA	6706	c.-596G>A	upstream_gene_variant	0.62	levofloxacin
gyrA	6706	c.-596G>A	upstream_gene_variant	0.62	moxifloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.62	levofloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.62	moxifloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.62	levofloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.62	moxifloxacin
gyrA	6727	c.-575G>T	upstream_gene_variant	0.65	levofloxacin
gyrA	6727	c.-575G>T	upstream_gene_variant	0.65	moxifloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.62	levofloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.62	moxifloxacin
gyrB	6745	c.1506T>G	synonymous_variant	0.68	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>G	synonymous_variant	0.68	moxifloxacin	Not assoc w R - Interim
gyrA	6760	c.-542G>C	upstream_gene_variant	0.69	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.69	moxifloxacin
gyrA	6778	c.-524C>T	upstream_gene_variant	0.72	levofloxacin
gyrA	6778	c.-524C>T	upstream_gene_variant	0.72	moxifloxacin
gyrB	6793	c.1554T>C	synonymous_variant	0.77	levofloxacin	Not assoc w R - Interim
gyrB	6793	c.1554T>C	synonymous_variant	0.77	moxifloxacin	Not assoc w R - Interim
gyrB	6797	p.Gly520Thr	missense_variant	0.75	levofloxacin
gyrB	6797	p.Gly520Thr	missense_variant	0.75	moxifloxacin
gyrB	6824	c.1585C>T	synonymous_variant	0.78	levofloxacin	Not assoc w R - Interim
gyrB	6824	c.1585C>T	synonymous_variant	0.78	moxifloxacin	Not assoc w R - Interim
gyrB	6841	c.1602T>C	synonymous_variant	0.77	levofloxacin	Not assoc w R - Interim
gyrB	6841	c.1602T>C	synonymous_variant	0.77	moxifloxacin	Not assoc w R - Interim
gyrA	6844	c.-458T>G	upstream_gene_variant	0.77	levofloxacin
gyrA	6844	c.-458T>G	upstream_gene_variant	0.77	moxifloxacin
gyrA	6853	c.-449A>G	upstream_gene_variant	0.76	levofloxacin
gyrA	6853	c.-449A>G	upstream_gene_variant	0.76	moxifloxacin
gyrB	6856	c.1617T>C	synonymous_variant	0.76	levofloxacin	Not assoc w R - Interim
gyrB	6856	c.1617T>C	synonymous_variant	0.76	moxifloxacin	Not assoc w R - Interim
gyrB	6859	c.1620T>C	synonymous_variant	0.76	levofloxacin	Not assoc w R - Interim
gyrB	6859	c.1620T>C	synonymous_variant	0.76	moxifloxacin	Not assoc w R - Interim
gyrB	6862	c.1623C>G	synonymous_variant	0.76	levofloxacin	Not assoc w R - Interim
gyrB	6862	c.1623C>G	synonymous_variant	0.76	moxifloxacin	Not assoc w R - Interim
gyrB	6878	c.1639T>C	synonymous_variant	0.78	levofloxacin	Not assoc w R - Interim
gyrB	6878	c.1639T>C	synonymous_variant	0.78	moxifloxacin	Not assoc w R - Interim
gyrB	6881	c.1642T>C	synonymous_variant	0.78	levofloxacin	Not assoc w R - Interim
gyrB	6881	c.1642T>C	synonymous_variant	0.78	moxifloxacin	Not assoc w R - Interim
gyrA	6904	c.-398C>G	upstream_gene_variant	0.8	levofloxacin
gyrA	6904	c.-398C>G	upstream_gene_variant	0.8	moxifloxacin
gyrA	6910	c.-392G>A	upstream_gene_variant	0.76	levofloxacin
gyrA	6910	c.-392G>A	upstream_gene_variant	0.76	moxifloxacin
gyrB	6911	p.Asn558His	missense_variant	0.74	levofloxacin
gyrB	6911	p.Asn558His	missense_variant	0.74	moxifloxacin
gyrB	6919	c.1680T>C	synonymous_variant	0.74	levofloxacin	Not assoc w R - Interim
gyrB	6919	c.1680T>C	synonymous_variant	0.74	moxifloxacin	Not assoc w R - Interim
gyrA	6925	c.-377T>C	upstream_gene_variant	0.69	levofloxacin
gyrA	6925	c.-377T>C	upstream_gene_variant	0.69	moxifloxacin
gyrA	6931	c.-371A>C	upstream_gene_variant	0.65	levofloxacin
gyrA	6931	c.-371A>C	upstream_gene_variant	0.65	moxifloxacin
gyrA	6934	c.-368A>G	upstream_gene_variant	0.63	levofloxacin
gyrA	6934	c.-368A>G	upstream_gene_variant	0.63	moxifloxacin
gyrB	6937	c.1698G>A	synonymous_variant	0.65	levofloxacin	Not assoc w R - Interim
gyrB	6937	c.1698G>A	synonymous_variant	0.65	moxifloxacin	Not assoc w R - Interim
gyrA	6949	c.-353A>G	upstream_gene_variant	0.63	levofloxacin
gyrA	6949	c.-353A>G	upstream_gene_variant	0.63	moxifloxacin
gyrB	6952	c.1713C>G	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
gyrB	6952	c.1713C>G	synonymous_variant	0.63	moxifloxacin	Not assoc w R - Interim
gyrA	6955	c.-347G>A	upstream_gene_variant	0.63	levofloxacin
gyrA	6955	c.-347G>A	upstream_gene_variant	0.63	moxifloxacin
gyrA	6967	c.-335T>C	upstream_gene_variant	0.64	levofloxacin
gyrA	6967	c.-335T>C	upstream_gene_variant	0.64	moxifloxacin
gyrA	6970	c.-332C>T	upstream_gene_variant	0.64	levofloxacin
gyrA	6970	c.-332C>T	upstream_gene_variant	0.64	moxifloxacin
gyrB	6973	c.1734G>A	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrB	6973	c.1734G>A	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	6976	c.-326A>G	upstream_gene_variant	0.56	levofloxacin
gyrA	6976	c.-326A>G	upstream_gene_variant	0.56	moxifloxacin
gyrA	6982	c.-320A>C	upstream_gene_variant	0.56	levofloxacin
gyrA	6982	c.-320A>C	upstream_gene_variant	0.56	moxifloxacin
gyrA	7000	c.-302C>G	upstream_gene_variant	0.58	levofloxacin
gyrA	7000	c.-302C>G	upstream_gene_variant	0.58	moxifloxacin
gyrA	7006	c.-296T>G	upstream_gene_variant	0.58	levofloxacin
gyrA	7006	c.-296T>G	upstream_gene_variant	0.58	moxifloxacin
gyrB	7012	c.1773G>C	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrB	7012	c.1773G>C	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrA	7018	c.-284G>C	upstream_gene_variant	0.53	levofloxacin
gyrA	7018	c.-284G>C	upstream_gene_variant	0.53	moxifloxacin
gyrA	7021	c.-281G>C	upstream_gene_variant	0.53	levofloxacin
gyrA	7021	c.-281G>C	upstream_gene_variant	0.53	moxifloxacin
gyrA	7033	c.-269G>C	upstream_gene_variant	0.5	levofloxacin
gyrA	7033	c.-269G>C	upstream_gene_variant	0.5	moxifloxacin
gyrB	7051	p.Glu604Asp	missense_variant	0.41	levofloxacin
gyrB	7051	p.Glu604Asp	missense_variant	0.41	moxifloxacin
gyrB	7060	c.1821T>C	synonymous_variant	0.43	levofloxacin	Not assoc w R - Interim
gyrB	7060	c.1821T>C	synonymous_variant	0.43	moxifloxacin	Not assoc w R - Interim
gyrA	7066	c.-236G>C	upstream_gene_variant	0.44	levofloxacin
gyrA	7066	c.-236G>C	upstream_gene_variant	0.44	moxifloxacin
gyrA	7165	c.-137C>G	upstream_gene_variant	0.26	levofloxacin
gyrA	7165	c.-137C>G	upstream_gene_variant	0.26	moxifloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.25	levofloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.25	moxifloxacin
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7427	c.126G>C	synonymous_variant	0.45	levofloxacin
gyrA	7427	c.126G>C	synonymous_variant	0.45	moxifloxacin
gyrA	7442	c.141G>C	synonymous_variant	0.57	levofloxacin
gyrA	7442	c.141G>C	synonymous_variant	0.57	moxifloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.58	levofloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.58	moxifloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.59	levofloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.59	moxifloxacin
gyrA	7472	c.171T>C	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	7472	c.171T>C	synonymous_variant	0.57	moxifloxacin
gyrA	7475	c.174A>C	synonymous_variant	0.57	levofloxacin
gyrA	7475	c.174A>C	synonymous_variant	0.57	moxifloxacin
gyrA	7480	p.Phe60Tyr	missense_variant	0.59	levofloxacin
gyrA	7480	p.Phe60Tyr	missense_variant	0.59	moxifloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.59	levofloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.59	moxifloxacin
gyrA	7487	c.186C>G	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrA	7487	c.186C>G	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrA	7490	c.189C>T	synonymous_variant	0.59	levofloxacin
gyrA	7490	c.189C>T	synonymous_variant	0.59	moxifloxacin
gyrA	7523	c.222C>G	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrA	7523	c.222C>G	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.65	levofloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.65	moxifloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.63	moxifloxacin	Not assoc w R - Interim
gyrA	7571	c.270G>C	synonymous_variant	0.66	levofloxacin	Not assoc w R - Interim
gyrA	7571	c.270G>C	synonymous_variant	0.66	moxifloxacin	Not assoc w R - Interim
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7595	c.294C>G	synonymous_variant	0.6	levofloxacin
gyrA	7595	c.294C>G	synonymous_variant	0.6	moxifloxacin
gyrA	7607	c.306C>G	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	7607	c.306C>G	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	7626	c.325C>T	synonymous_variant	0.56	levofloxacin
gyrA	7626	c.325C>T	synonymous_variant	0.56	moxifloxacin
gyrA	7631	c.330G>C	synonymous_variant	0.55	levofloxacin
gyrA	7631	c.330G>C	synonymous_variant	0.55	moxifloxacin
gyrA	7637	c.336C>G	synonymous_variant	0.56	levofloxacin
gyrA	7637	c.336C>G	synonymous_variant	0.56	moxifloxacin
gyrA	7652	c.351C>T	synonymous_variant	0.57	levofloxacin
gyrA	7652	c.351C>T	synonymous_variant	0.57	moxifloxacin
gyrA	7658	c.357A>G	synonymous_variant	0.62	levofloxacin
gyrA	7658	c.357A>G	synonymous_variant	0.62	moxifloxacin
gyrA	7664	c.363T>C	synonymous_variant	0.62	levofloxacin
gyrA	7664	c.363T>C	synonymous_variant	0.62	moxifloxacin
gyrA	7670	c.369A>G	synonymous_variant	0.64	levofloxacin
gyrA	7670	c.369A>G	synonymous_variant	0.64	moxifloxacin
gyrA	7676	c.375G>C	synonymous_variant	0.65	levofloxacin
gyrA	7676	c.375G>C	synonymous_variant	0.65	moxifloxacin
gyrA	7683	c.382A>C	synonymous_variant	0.66	levofloxacin
gyrA	7683	c.382A>C	synonymous_variant	0.66	moxifloxacin
gyrA	7694	c.393A>G	synonymous_variant	0.66	levofloxacin
gyrA	7694	c.393A>G	synonymous_variant	0.66	moxifloxacin
gyrA	7697	c.396C>G	synonymous_variant	0.68	levofloxacin
gyrA	7697	c.396C>G	synonymous_variant	0.68	moxifloxacin
gyrA	7710	c.409T>C	synonymous_variant	0.67	levofloxacin
gyrA	7710	c.409T>C	synonymous_variant	0.67	moxifloxacin
gyrA	7715	c.414G>C	synonymous_variant	0.68	levofloxacin
gyrA	7715	c.414G>C	synonymous_variant	0.68	moxifloxacin
gyrA	7728	c.427_429delAGGinsCC	frameshift_variant&missense_variant	0.68	levofloxacin
gyrA	7728	c.427_429delAGGinsCC	frameshift_variant&missense_variant	0.68	moxifloxacin
gyrA	7760	c.459C>T	synonymous_variant	0.68	levofloxacin
gyrA	7760	c.459C>T	synonymous_variant	0.68	moxifloxacin
gyrA	7763	c.462T>C	synonymous_variant	0.71	levofloxacin	Not assoc w R - Interim
gyrA	7763	c.462T>C	synonymous_variant	0.71	moxifloxacin	Not assoc w R - Interim
gyrA	7799	c.498A>G	synonymous_variant	0.67	levofloxacin	Not assoc w R - Interim
gyrA	7799	c.498A>G	synonymous_variant	0.67	moxifloxacin	Not assoc w R - Interim
gyrA	7835	c.534A>G	synonymous_variant	0.66	levofloxacin	Not assoc w R - Interim
gyrA	7835	c.534A>G	synonymous_variant	0.66	moxifloxacin	Not assoc w R - Interim
gyrA	7838	c.537C>G	synonymous_variant	0.65	levofloxacin
gyrA	7838	c.537C>G	synonymous_variant	0.65	moxifloxacin
gyrA	7859	c.558A>C	synonymous_variant	0.7	levofloxacin
gyrA	7859	c.558A>C	synonymous_variant	0.7	moxifloxacin
gyrA	7865	c.564T>C	synonymous_variant	0.68	levofloxacin
gyrA	7865	c.564T>C	synonymous_variant	0.68	moxifloxacin
gyrA	7883	c.582G>C	synonymous_variant	0.72	levofloxacin
gyrA	7883	c.582G>C	synonymous_variant	0.72	moxifloxacin
gyrA	7884	c.583_585delCGTinsGC	frameshift_variant&missense_variant	0.7	levofloxacin
gyrA	7884	c.583_585delCGTinsGC	frameshift_variant&missense_variant	0.7	moxifloxacin
gyrA	7892	c.591G>C	synonymous_variant	0.71	levofloxacin
gyrA	7892	c.591G>C	synonymous_variant	0.71	moxifloxacin
gyrA	7898	p.Asp199Glu	missense_variant	0.74	levofloxacin
gyrA	7898	p.Asp199Glu	missense_variant	0.74	moxifloxacin
gyrA	7919	p.Glu206Asp	missense_variant	0.7	levofloxacin
gyrA	7919	p.Glu206Asp	missense_variant	0.7	moxifloxacin
gyrA	7923	p.His208Tyr	missense_variant	0.66	levofloxacin
gyrA	7923	p.His208Tyr	missense_variant	0.66	moxifloxacin
gyrA	7928	p.Asp209Glu	missense_variant	0.65	levofloxacin
gyrA	7928	p.Asp209Glu	missense_variant	0.65	moxifloxacin
gyrA	7942	p.Glu214Ala	missense_variant	0.6	levofloxacin
gyrA	7942	p.Glu214Ala	missense_variant	0.6	moxifloxacin
gyrA	7955	c.654G>C	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrA	7955	c.654G>C	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	7958	c.657C>G	synonymous_variant	0.59	levofloxacin
gyrA	7958	c.657C>G	synonymous_variant	0.59	moxifloxacin
gyrA	7963	p.Gly221Glu	missense_variant	0.59	levofloxacin
gyrA	7963	p.Gly221Glu	missense_variant	0.59	moxifloxacin
gyrA	7970	c.669T>G	synonymous_variant	0.6	levofloxacin
gyrA	7970	c.669T>G	synonymous_variant	0.6	moxifloxacin
gyrA	7979	c.678G>C	synonymous_variant	0.62	levofloxacin
gyrA	7979	c.678G>C	synonymous_variant	0.62	moxifloxacin
gyrA	7992	p.Ala231Ser	missense_variant	0.61	levofloxacin
gyrA	7992	p.Ala231Ser	missense_variant	0.61	moxifloxacin
gyrA	7997	c.696A>C	synonymous_variant	0.61	levofloxacin
gyrA	7997	c.696A>C	synonymous_variant	0.61	moxifloxacin
gyrA	8009	c.708A>C	synonymous_variant	0.58	levofloxacin
gyrA	8009	c.708A>C	synonymous_variant	0.58	moxifloxacin
gyrA	8010	c.709_711delTCCinsAG	frameshift_variant&synonymous_variant	0.58	levofloxacin
gyrA	8010	c.709_711delTCCinsAG	frameshift_variant&synonymous_variant	0.58	moxifloxacin
gyrA	8020	p.Thr240Ile	missense_variant	0.59	levofloxacin
gyrA	8020	p.Thr240Ile	missense_variant	0.59	moxifloxacin
gyrA	8024	c.723T>C	synonymous_variant	0.59	levofloxacin
gyrA	8024	c.723T>C	synonymous_variant	0.59	moxifloxacin
gyrA	8027	c.726T>C	synonymous_variant	0.62	levofloxacin
gyrA	8027	c.726T>C	synonymous_variant	0.62	moxifloxacin
gyrA	8036	c.735A>G	synonymous_variant	0.64	levofloxacin	Not assoc w R - Interim
gyrA	8036	c.735A>G	synonymous_variant	0.64	moxifloxacin	Not assoc w R - Interim
gyrA	8039	c.738T>C	synonymous_variant	0.67	levofloxacin	Not assoc w R - Interim
gyrA	8039	c.738T>C	synonymous_variant	0.67	moxifloxacin	Not assoc w R - Interim
gyrA	8054	c.753T>C	synonymous_variant	0.64	levofloxacin	Not assoc w R - Interim
gyrA	8054	c.753T>C	synonymous_variant	0.64	moxifloxacin	Not assoc w R - Interim
gyrA	8057	c.756A>G	synonymous_variant	0.64	levofloxacin
gyrA	8057	c.756A>G	synonymous_variant	0.64	moxifloxacin
gyrA	8069	c.768T>C	synonymous_variant	0.63	levofloxacin
gyrA	8069	c.768T>C	synonymous_variant	0.63	moxifloxacin
gyrA	8078	c.777A>G	synonymous_variant	0.65	levofloxacin
gyrA	8078	c.777A>G	synonymous_variant	0.65	moxifloxacin
gyrA	8090	c.789C>G	synonymous_variant	0.64	levofloxacin
gyrA	8090	c.789C>G	synonymous_variant	0.64	moxifloxacin
gyrA	8093	c.792C>G	synonymous_variant	0.62	levofloxacin
gyrA	8093	c.792C>G	synonymous_variant	0.62	moxifloxacin
gyrA	8096	c.795T>C	synonymous_variant	0.65	levofloxacin
gyrA	8096	c.795T>C	synonymous_variant	0.65	moxifloxacin
gyrA	8099	c.798T>C	synonymous_variant	0.67	levofloxacin
gyrA	8099	c.798T>C	synonymous_variant	0.67	moxifloxacin
gyrA	8111	c.810G>C	synonymous_variant	0.68	levofloxacin
gyrA	8111	c.810G>C	synonymous_variant	0.68	moxifloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.64	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.64	moxifloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.68	levofloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.68	moxifloxacin
gyrA	8174	c.873C>G	synonymous_variant	0.71	levofloxacin
gyrA	8174	c.873C>G	synonymous_variant	0.71	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.69	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.69	moxifloxacin
gyrA	8198	c.897T>C	synonymous_variant	0.71	levofloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.71	moxifloxacin	Not assoc w R - Interim
gyrA	8207	c.906T>C	synonymous_variant	0.72	levofloxacin
gyrA	8207	c.906T>C	synonymous_variant	0.72	moxifloxacin
gyrA	8219	c.918T>C	synonymous_variant	0.74	levofloxacin	Not assoc w R - Interim
gyrA	8219	c.918T>C	synonymous_variant	0.74	moxifloxacin	Not assoc w R - Interim
gyrA	8225	c.924T>C	synonymous_variant	0.71	levofloxacin
gyrA	8225	c.924T>C	synonymous_variant	0.71	moxifloxacin
gyrA	8234	c.933T>G	synonymous_variant	0.69	levofloxacin	Not assoc w R - Interim
gyrA	8234	c.933T>G	synonymous_variant	0.69	moxifloxacin	Not assoc w R - Interim
gyrA	8235	c.934_936delTTAinsCG	frameshift_variant&missense_variant	0.69	levofloxacin
gyrA	8235	c.934_936delTTAinsCG	frameshift_variant&missense_variant	0.69	moxifloxacin
gyrA	8253	p.Ile318Leu	missense_variant	0.67	levofloxacin
gyrA	8253	p.Ile318Leu	missense_variant	0.67	moxifloxacin
gyrA	8264	c.963T>C	synonymous_variant	0.68	levofloxacin
gyrA	8264	c.963T>C	synonymous_variant	0.68	moxifloxacin
gyrA	8267	c.966G>C	synonymous_variant	0.68	levofloxacin	Not assoc w R - Interim
gyrA	8267	c.966G>C	synonymous_variant	0.68	moxifloxacin	Not assoc w R - Interim
gyrA	8270	c.969G>C	synonymous_variant	0.64	levofloxacin
gyrA	8270	c.969G>C	synonymous_variant	0.64	moxifloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.61	levofloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.61	moxifloxacin
gyrA	8288	c.987T>C	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrA	8288	c.987T>C	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.65	levofloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.65	moxifloxacin	Not assoc w R - Interim
gyrA	8324	c.1023T>C	synonymous_variant	0.6	levofloxacin
gyrA	8324	c.1023T>C	synonymous_variant	0.6	moxifloxacin
gyrA	8339	c.1038A>G	synonymous_variant	0.58	levofloxacin
gyrA	8339	c.1038A>G	synonymous_variant	0.58	moxifloxacin
gyrA	8342	c.1041G>C	synonymous_variant	0.56	levofloxacin
gyrA	8342	c.1041G>C	synonymous_variant	0.56	moxifloxacin
gyrA	8348	c.1047C>A	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrA	8348	c.1047C>A	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrA	8363	c.1062C>A	synonymous_variant	0.56	levofloxacin
gyrA	8363	c.1062C>A	synonymous_variant	0.56	moxifloxacin
gyrA	8366	c.1065G>C	synonymous_variant	0.59	levofloxacin
gyrA	8366	c.1065G>C	synonymous_variant	0.59	moxifloxacin
gyrA	8375	c.1074G>C	synonymous_variant	0.68	levofloxacin	Not assoc w R - Interim
gyrA	8375	c.1074G>C	synonymous_variant	0.68	moxifloxacin
gyrA	8391	c.1090_1092delTATinsCC	frameshift_variant&missense_variant	0.67	levofloxacin
gyrA	8391	c.1090_1092delTATinsCC	frameshift_variant&missense_variant	0.67	moxifloxacin
gyrA	8399	c.1098T>C	synonymous_variant	0.68	levofloxacin	Not assoc w R - Interim
gyrA	8399	c.1098T>C	synonymous_variant	0.68	moxifloxacin	Not assoc w R - Interim
gyrA	8420	c.1119T>C	synonymous_variant	0.63	levofloxacin
gyrA	8420	c.1119T>C	synonymous_variant	0.63	moxifloxacin
gyrA	8423	c.1122G>C	synonymous_variant	0.63	levofloxacin
gyrA	8423	c.1122G>C	synonymous_variant	0.63	moxifloxacin
gyrA	8442	c.1141C>T	synonymous_variant	0.64	levofloxacin
gyrA	8442	c.1141C>T	synonymous_variant	0.64	moxifloxacin
gyrA	8453	c.1152A>C	synonymous_variant	0.64	levofloxacin
gyrA	8453	c.1152A>C	synonymous_variant	0.64	moxifloxacin
gyrA	8462	c.1161A>G	synonymous_variant	0.63	levofloxacin
gyrA	8462	c.1161A>G	synonymous_variant	0.63	moxifloxacin
gyrA	8471	c.1170T>C	synonymous_variant	0.62	levofloxacin
gyrA	8471	c.1170T>C	synonymous_variant	0.62	moxifloxacin
gyrA	8480	c.1179C>T	synonymous_variant	0.62	levofloxacin
gyrA	8480	c.1179C>T	synonymous_variant	0.62	moxifloxacin
gyrA	8486	c.1185T>C	synonymous_variant	0.6	levofloxacin	Not assoc w R - Interim
gyrA	8486	c.1185T>C	synonymous_variant	0.6	moxifloxacin	Not assoc w R - Interim
gyrA	8489	c.1188A>G	synonymous_variant	0.58	levofloxacin
gyrA	8489	c.1188A>G	synonymous_variant	0.58	moxifloxacin
gyrA	8498	c.1197C>T	synonymous_variant	0.56	levofloxacin
gyrA	8498	c.1197C>T	synonymous_variant	0.56	moxifloxacin
gyrA	8504	c.1203G>C	synonymous_variant	0.58	levofloxacin
gyrA	8504	c.1203G>C	synonymous_variant	0.58	moxifloxacin
gyrA	8516	c.1215T>C	synonymous_variant	0.56	levofloxacin
gyrA	8516	c.1215T>C	synonymous_variant	0.56	moxifloxacin
gyrA	8519	c.1218A>C	synonymous_variant	0.57	levofloxacin
gyrA	8519	c.1218A>C	synonymous_variant	0.57	moxifloxacin
gyrA	8537	c.1236G>A	synonymous_variant	0.51	levofloxacin
gyrA	8537	c.1236G>A	synonymous_variant	0.51	moxifloxacin
gyrA	8546	c.1245T>C	synonymous_variant	0.47	levofloxacin	Not assoc w R - Interim
gyrA	8546	c.1245T>C	synonymous_variant	0.47	moxifloxacin	Not assoc w R - Interim
gyrA	8552	c.1251C>G	synonymous_variant	0.45	levofloxacin
gyrA	8552	c.1251C>G	synonymous_variant	0.45	moxifloxacin
gyrA	8556	p.Ala419Gln	missense_variant	0.45	levofloxacin
gyrA	8556	p.Ala419Gln	missense_variant	0.45	moxifloxacin
gyrA	8561	c.1260A>C	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrA	8561	c.1260A>C	synonymous_variant	0.45	moxifloxacin	Not assoc w R - Interim
gyrA	8562	c.1261C>T	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrA	8562	c.1261C>T	synonymous_variant	0.45	moxifloxacin	Not assoc w R - Interim
gyrA	8603	c.1302A>G	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrA	8603	c.1302A>G	synonymous_variant	0.5	moxifloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.56	levofloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.56	moxifloxacin	Not assoc w R - Interim
gyrA	8624	c.1323G>C	synonymous_variant	0.55	levofloxacin
gyrA	8624	c.1323G>C	synonymous_variant	0.55	moxifloxacin
gyrA	8627	c.1326C>G	synonymous_variant	0.52	levofloxacin
gyrA	8627	c.1326C>G	synonymous_variant	0.52	moxifloxacin
gyrA	8636	c.1335A>C	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>C	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrA	8642	c.1341A>G	synonymous_variant	0.55	levofloxacin
gyrA	8642	c.1341A>G	synonymous_variant	0.55	moxifloxacin
gyrA	8645	c.1344C>G	synonymous_variant	0.55	levofloxacin
gyrA	8645	c.1344C>G	synonymous_variant	0.55	moxifloxacin
gyrA	8672	c.1371A>G	synonymous_variant	0.6	levofloxacin	Not assoc w R - Interim
gyrA	8672	c.1371A>G	synonymous_variant	0.6	moxifloxacin	Not assoc w R - Interim
gyrA	8693	c.1392T>C	synonymous_variant	0.63	levofloxacin
gyrA	8693	c.1392T>C	synonymous_variant	0.63	moxifloxacin
gyrA	8699	c.1398A>G	synonymous_variant	0.62	levofloxacin
gyrA	8699	c.1398A>G	synonymous_variant	0.62	moxifloxacin
gyrA	8711	c.1410A>C	synonymous_variant	0.61	levofloxacin
gyrA	8711	c.1410A>C	synonymous_variant	0.61	moxifloxacin
gyrA	8714	c.1413A>G	synonymous_variant	0.62	levofloxacin
gyrA	8714	c.1413A>G	synonymous_variant	0.62	moxifloxacin
gyrA	8717	c.1416C>G	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
gyrA	8717	c.1416C>G	synonymous_variant	0.63	moxifloxacin	Not assoc w R - Interim
gyrA	8720	c.1419G>A	synonymous_variant	0.63	levofloxacin
gyrA	8720	c.1419G>A	synonymous_variant	0.63	moxifloxacin
gyrA	8729	c.1428T>C	synonymous_variant	0.62	levofloxacin
gyrA	8729	c.1428T>C	synonymous_variant	0.62	moxifloxacin
gyrA	8732	c.1431G>C	synonymous_variant	0.6	levofloxacin
gyrA	8732	c.1431G>C	synonymous_variant	0.6	moxifloxacin
gyrA	8747	c.1446A>G	synonymous_variant	0.61	levofloxacin
gyrA	8747	c.1446A>G	synonymous_variant	0.61	moxifloxacin
gyrA	8756	c.1455A>G	synonymous_variant	0.6	levofloxacin	Not assoc w R - Interim
gyrA	8756	c.1455A>G	synonymous_variant	0.6	moxifloxacin	Not assoc w R - Interim
gyrA	8762	c.1461G>C	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrA	8762	c.1461G>C	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	8765	p.Asp488Glu	missense_variant	0.61	levofloxacin	Uncertain significance
gyrA	8765	p.Asp488Glu	missense_variant	0.61	moxifloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.62	levofloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.62	moxifloxacin	Uncertain significance
gyrA	8779	p.Asp493Ala	missense_variant	0.68	levofloxacin
gyrA	8779	p.Asp493Ala	missense_variant	0.68	moxifloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.7	levofloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.7	moxifloxacin
gyrA	8796	c.1495_1497delATCinsGG	frameshift_variant&missense_variant	0.7	levofloxacin
gyrA	8796	c.1495_1497delATCinsGG	frameshift_variant&missense_variant	0.7	moxifloxacin
gyrA	8801	c.1500G>C	synonymous_variant	0.7	levofloxacin
gyrA	8801	c.1500G>C	synonymous_variant	0.7	moxifloxacin
gyrA	8810	c.1509A>C	synonymous_variant	0.72	levofloxacin
gyrA	8810	c.1509A>C	synonymous_variant	0.72	moxifloxacin
gyrA	8829	c.1528T>C	synonymous_variant	0.71	levofloxacin	Not assoc w R - Interim
gyrA	8829	c.1528T>C	synonymous_variant	0.71	moxifloxacin	Not assoc w R - Interim
gyrA	8852	c.1551T>C	synonymous_variant	0.7	levofloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.7	moxifloxacin
gyrA	8858	c.1557T>C	synonymous_variant	0.7	levofloxacin
gyrA	8858	c.1557T>C	synonymous_variant	0.7	moxifloxacin
gyrA	8867	c.1566A>G	synonymous_variant	0.69	levofloxacin	Not assoc w R - Interim
gyrA	8867	c.1566A>G	synonymous_variant	0.69	moxifloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.69	levofloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.69	moxifloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	0.69	levofloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	0.69	moxifloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.7	levofloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.7	moxifloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.69	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.69	moxifloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.69	levofloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.69	moxifloxacin	Not assoc w R - Interim
gyrA	8918	c.1617C>G	synonymous_variant	0.67	levofloxacin
gyrA	8918	c.1617C>G	synonymous_variant	0.67	moxifloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.57	levofloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.57	moxifloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.57	levofloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.57	moxifloxacin
gyrA	8945	c.1644G>C	synonymous_variant	0.55	levofloxacin
gyrA	8945	c.1644G>C	synonymous_variant	0.55	moxifloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	0.55	levofloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	0.55	moxifloxacin
gyrA	8951	c.1650G>A	synonymous_variant	0.59	levofloxacin
gyrA	8951	c.1650G>A	synonymous_variant	0.59	moxifloxacin
gyrA	8966	c.1665C>G	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	8966	c.1665C>G	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	8967	p.Ala556Arg	missense_variant	0.57	levofloxacin
gyrA	8967	p.Ala556Arg	missense_variant	0.57	moxifloxacin
gyrA	8987	c.1686C>G	synonymous_variant	0.61	levofloxacin
gyrA	8987	c.1686C>G	synonymous_variant	0.61	moxifloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.61	levofloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.61	moxifloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.61	levofloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.61	moxifloxacin
gyrA	8998	p.Leu566Trp	missense_variant	0.61	levofloxacin	Uncertain significance
gyrA	8998	p.Leu566Trp	missense_variant	0.61	moxifloxacin	Uncertain significance
gyrA	9023	c.1722A>T	synonymous_variant	0.57	levofloxacin
gyrA	9023	c.1722A>T	synonymous_variant	0.57	moxifloxacin
gyrA	9029	c.1728T>C	synonymous_variant	0.54	levofloxacin
gyrA	9029	c.1728T>C	synonymous_variant	0.54	moxifloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.54	levofloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.54	moxifloxacin
gyrA	9035	c.1734G>C	synonymous_variant	0.56	levofloxacin	Not assoc w R - Interim
gyrA	9035	c.1734G>C	synonymous_variant	0.56	moxifloxacin
gyrA	9050	p.Asp583Glu	missense_variant	0.5	levofloxacin	Uncertain significance
gyrA	9050	p.Asp583Glu	missense_variant	0.5	moxifloxacin	Uncertain significance
gyrA	9051	c.1750T>C	synonymous_variant	0.5	levofloxacin
gyrA	9051	c.1750T>C	synonymous_variant	0.5	moxifloxacin
gyrA	9062	c.1761C>G	synonymous_variant	0.48	levofloxacin
gyrA	9062	c.1761C>G	synonymous_variant	0.48	moxifloxacin
gyrA	9068	c.1767G>C	synonymous_variant	0.48	levofloxacin
gyrA	9068	c.1767G>C	synonymous_variant	0.48	moxifloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.44	levofloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.44	moxifloxacin
gyrA	9074	c.1773G>C	synonymous_variant	0.44	levofloxacin
gyrA	9074	c.1773G>C	synonymous_variant	0.44	moxifloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.46	levofloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.46	moxifloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	0.43	levofloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	0.43	moxifloxacin
gyrA	9104	c.1803C>G	synonymous_variant	0.43	levofloxacin	Not assoc w R - Interim
gyrA	9104	c.1803C>G	synonymous_variant	0.43	moxifloxacin	Not assoc w R - Interim
gyrA	9122	c.1821C>G	synonymous_variant	0.39	levofloxacin	Not assoc w R - Interim
gyrA	9122	c.1821C>G	synonymous_variant	0.39	moxifloxacin	Not assoc w R - Interim
gyrA	9134	c.1833C>G	synonymous_variant	0.39	levofloxacin
gyrA	9134	c.1833C>G	synonymous_variant	0.39	moxifloxacin
gyrA	9143	c.1842T>C	synonymous_variant	0.36	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	0.36	moxifloxacin	Not assoc w R
gyrA	9147	p.Gly616Ser	missense_variant	0.36	levofloxacin
gyrA	9147	p.Gly616Ser	missense_variant	0.36	moxifloxacin
gyrA	9152	c.1851C>T	synonymous_variant	0.33	levofloxacin	Not assoc w R - Interim
gyrA	9152	c.1851C>T	synonymous_variant	0.33	moxifloxacin	Not assoc w R - Interim
gyrA	9153	p.Thr618Glu	missense_variant	0.33	levofloxacin
gyrA	9153	p.Thr618Glu	missense_variant	0.33	moxifloxacin
gyrA	9164	c.1863G>C	synonymous_variant	0.38	levofloxacin
gyrA	9164	c.1863G>C	synonymous_variant	0.38	moxifloxacin
gyrA	9182	c.1881T>C	synonymous_variant	0.44	levofloxacin	Not assoc w R - Interim
gyrA	9182	c.1881T>C	synonymous_variant	0.44	moxifloxacin	Not assoc w R - Interim
gyrA	9191	c.1890G>C	synonymous_variant	0.44	levofloxacin
gyrA	9191	c.1890G>C	synonymous_variant	0.44	moxifloxacin
gyrA	9200	c.1899A>G	synonymous_variant	0.42	levofloxacin	Not assoc w R - Interim
gyrA	9200	c.1899A>G	synonymous_variant	0.42	moxifloxacin	Not assoc w R - Interim
gyrA	9227	c.1926C>G	synonymous_variant	0.4	levofloxacin	Not assoc w R - Interim
gyrA	9227	c.1926C>G	synonymous_variant	0.4	moxifloxacin	Not assoc w R - Interim
gyrA	9230	c.1929T>C	synonymous_variant	0.4	levofloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.4	moxifloxacin
gyrA	9233	c.1932C>T	synonymous_variant	0.4	levofloxacin
gyrA	9233	c.1932C>T	synonymous_variant	0.4	moxifloxacin
gyrA	9242	c.1941A>C	synonymous_variant	0.44	levofloxacin
gyrA	9242	c.1941A>C	synonymous_variant	0.44	moxifloxacin
gyrA	9252	p.Val651Ile	missense_variant	0.46	levofloxacin	Uncertain significance
gyrA	9252	p.Val651Ile	missense_variant	0.46	moxifloxacin	Uncertain significance
gyrA	9275	c.1974G>A	synonymous_variant	0.48	levofloxacin
gyrA	9275	c.1974G>A	synonymous_variant	0.48	moxifloxacin
gyrA	9278	c.1977G>C	synonymous_variant	0.48	levofloxacin	Not assoc w R - Interim
gyrA	9278	c.1977G>C	synonymous_variant	0.48	moxifloxacin	Not assoc w R - Interim
gyrA	9281	c.1980C>G	synonymous_variant	0.48	levofloxacin
gyrA	9281	c.1980C>G	synonymous_variant	0.48	moxifloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.46	levofloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.46	moxifloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.44	levofloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.44	moxifloxacin
gyrA	9296	c.1995T>C	synonymous_variant	0.44	levofloxacin	Not assoc w R - Interim
gyrA	9296	c.1995T>C	synonymous_variant	0.44	moxifloxacin	Not assoc w R - Interim
gyrA	9304	p.Gly668Glu	missense_variant	1.0	levofloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	moxifloxacin
gyrA	9311	c.2010C>T	synonymous_variant	0.45	levofloxacin
gyrA	9311	c.2010C>T	synonymous_variant	0.45	moxifloxacin
gyrA	9323	c.2022C>G	synonymous_variant	0.43	levofloxacin	Not assoc w R - Interim
gyrA	9323	c.2022C>G	synonymous_variant	0.43	moxifloxacin	Not assoc w R - Interim
gyrA	9335	c.2034G>C	synonymous_variant	0.37	levofloxacin
gyrA	9335	c.2034G>C	synonymous_variant	0.37	moxifloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.39	levofloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.39	moxifloxacin
gyrA	9374	c.2073G>C	synonymous_variant	0.33	levofloxacin
gyrA	9374	c.2073G>C	synonymous_variant	0.33	moxifloxacin
gyrA	9377	c.2076A>G	synonymous_variant	0.33	levofloxacin	Not assoc w R - Interim
gyrA	9377	c.2076A>G	synonymous_variant	0.33	moxifloxacin	Not assoc w R - Interim
gyrA	9383	c.2082T>C	synonymous_variant	0.33	levofloxacin
gyrA	9383	c.2082T>C	synonymous_variant	0.33	moxifloxacin
gyrA	9386	c.2085T>C	synonymous_variant	0.33	levofloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	0.33	moxifloxacin	Not assoc w R - Interim
gyrA	9389	c.2088C>T	synonymous_variant	0.35	levofloxacin
gyrA	9389	c.2088C>T	synonymous_variant	0.35	moxifloxacin
gyrA	9395	c.2094G>C	synonymous_variant	0.35	levofloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	0.35	moxifloxacin	Not assoc w R - Interim
gyrA	9518	c.2217A>G	synonymous_variant	0.35	levofloxacin
gyrA	9518	c.2217A>G	synonymous_variant	0.35	moxifloxacin
gyrA	9521	c.2220C>T	synonymous_variant	0.35	levofloxacin
gyrA	9521	c.2220C>T	synonymous_variant	0.35	moxifloxacin
gyrA	9527	c.2226A>G	synonymous_variant	0.33	levofloxacin
gyrA	9527	c.2226A>G	synonymous_variant	0.33	moxifloxacin
gyrA	9542	c.2241T>C	synonymous_variant	0.37	levofloxacin
gyrA	9542	c.2241T>C	synonymous_variant	0.37	moxifloxacin
gyrA	9545	c.2244A>G	synonymous_variant	0.37	levofloxacin
gyrA	9545	c.2244A>G	synonymous_variant	0.37	moxifloxacin
gyrA	9548	c.2247T>C	synonymous_variant	0.37	levofloxacin	Not assoc w R - Interim
gyrA	9548	c.2247T>C	synonymous_variant	0.37	moxifloxacin	Not assoc w R - Interim
fgd1	490851	c.69A>C	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fgd1	490887	c.105G>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fgd1	490902	c.120T>C	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fgd1	490932	c.150T>C	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	490948	p.Ser56Ala	missense_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	490962	c.180T>C	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	490968	c.186C>G	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	490974	c.192T>C	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	490979	p.Asn66Thr	missense_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	490987	p.Leu69Thr	missense_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	490998	c.216T>C	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fgd1	491007	c.225G>C	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491010	c.228C>G	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491013	c.231C>G	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491031	c.249C>G	synonymous_variant	0.66	clofazimine
					pretomanid
					delamanid
fgd1	491038	p.Ile86Val	missense_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491043	c.261T>G	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fgd1	491049	c.267T>C	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fgd1	491063	p.Gly94Ala	missense_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491077	p.Asn99Gly	missense_variant	0.57	clofazimine
					pretomanid
					delamanid
fgd1	491082	c.300T>G	synonymous_variant	0.57	clofazimine
					pretomanid
					delamanid
fgd1	491091	c.309T>C	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fgd1	491094	c.312C>G	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491106	c.324T>C	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fgd1	491121	c.339A>G	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fgd1	491137	p.Glu119Gln	missense_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491144	p.Ala121Glu	missense_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491166	c.384G>C	synonymous_variant	0.74	clofazimine
					pretomanid
					delamanid
fgd1	491181	c.399T>C	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fgd1	491191	p.Gly137Arg	missense_variant	0.72	clofazimine
					pretomanid
					delamanid
fgd1	491196	c.414A>G	synonymous_variant	0.74	clofazimine
					pretomanid
					delamanid
fgd1	491202	c.420G>C	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fgd1	491203	p.Gln141Glu	missense_variant	0.75	clofazimine
					pretomanid
					delamanid
fgd1	491212	p.Ser144Arg	missense_variant	0.74	clofazimine
					pretomanid
					delamanid
fgd1	491217	c.435T>C	synonymous_variant	0.74	clofazimine
					pretomanid
					delamanid
fgd1	491232	c.450T>C	synonymous_variant	0.74	clofazimine
					pretomanid
					delamanid
fgd1	491241	p.Asp153Glu	missense_variant	0.7	clofazimine
					pretomanid
					delamanid
fgd1	491244	c.462T>C	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fgd1	491259	c.477T>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491286	c.504G>C	synonymous_variant	0.62	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fgd1	491292	c.510G>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491295	c.513C>G	synonymous_variant	0.6	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fgd1	491296	p.Val172Ile	missense_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491319	c.537G>C	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fgd1	491331	c.549G>A	synonymous_variant	0.69	clofazimine
					pretomanid
					delamanid
fgd1	491349	c.567T>C	synonymous_variant	0.58	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fgd1	491364	c.582T>C	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fgd1	491367	c.585G>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fgd1	491388	c.606C>G	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fgd1	491591	p.Lys270Met	missense_variant	1.0	clofazimine	Not assoc w R
					pretomanid
					delamanid	Uncertain significance
mshA	575641	c.294A>G	synonymous_variant	0.42	ethionamide
mshA	575641	c.294A>G	synonymous_variant	0.42	isoniazid
mshA	575648	p.Val101Gln	missense_variant	0.42	ethionamide
mshA	575648	p.Val101Gln	missense_variant	0.42	isoniazid
mshA	575658	p.Ala104Val	missense_variant	0.43	ethionamide
mshA	575658	p.Ala104Val	missense_variant	0.43	isoniazid
mshA	575665	c.318G>C	synonymous_variant	0.43	ethionamide	Not assoc w R - Interim
mshA	575665	c.318G>C	synonymous_variant	0.43	isoniazid	Not assoc w R - Interim
mshA	575669	p.Leu108Val	missense_variant	0.46	ethionamide
mshA	575669	p.Leu108Val	missense_variant	0.46	isoniazid
mshA	575689	c.342G>C	synonymous_variant	0.46	ethionamide
mshA	575689	c.342G>C	synonymous_variant	0.46	isoniazid
mshA	575695	c.348C>G	synonymous_variant	0.46	ethionamide
mshA	575695	c.348C>G	synonymous_variant	0.46	isoniazid	Not assoc w R - Interim
mshA	575704	c.357T>C	synonymous_variant	0.46	ethionamide
mshA	575704	c.357T>C	synonymous_variant	0.46	isoniazid
mshA	575705	c.358T>C	synonymous_variant	0.43	ethionamide
mshA	575705	c.358T>C	synonymous_variant	0.43	isoniazid
mshA	575713	c.366G>A	synonymous_variant	0.46	ethionamide
mshA	575713	c.366G>A	synonymous_variant	0.46	isoniazid
mshA	575719	c.372C>T	synonymous_variant	0.44	ethionamide	Not assoc w R - Interim
mshA	575719	c.372C>T	synonymous_variant	0.44	isoniazid	Not assoc w R - Interim
mshA	575734	c.387T>G	synonymous_variant	0.44	ethionamide
mshA	575734	c.387T>G	synonymous_variant	0.44	isoniazid
mshA	575737	c.390T>C	synonymous_variant	0.44	ethionamide
mshA	575737	c.390T>C	synonymous_variant	0.44	isoniazid
mshA	575746	c.399C>G	synonymous_variant	0.46	ethionamide
mshA	575746	c.399C>G	synonymous_variant	0.46	isoniazid
mshA	575767	c.420G>A	synonymous_variant	0.46	ethionamide
mshA	575767	c.420G>A	synonymous_variant	0.46	isoniazid
mshA	575771	p.Val142Ser	missense_variant	0.44	ethionamide
mshA	575771	p.Val142Ser	missense_variant	0.44	isoniazid
mshA	575779	c.432A>G	synonymous_variant	0.44	ethionamide
mshA	575779	c.432A>G	synonymous_variant	0.44	isoniazid
mshA	575821	c.474G>C	synonymous_variant	0.46	ethionamide
mshA	575821	c.474G>C	synonymous_variant	0.46	isoniazid
mshA	575824	c.477T>G	synonymous_variant	0.46	ethionamide
mshA	575824	c.477T>G	synonymous_variant	0.46	isoniazid
mshA	575864	c.517T>C	synonymous_variant	0.42	ethionamide
mshA	575864	c.517T>C	synonymous_variant	0.42	isoniazid
mshA	575878	c.531A>G	synonymous_variant	0.5	ethionamide
mshA	575878	c.531A>G	synonymous_variant	0.5	isoniazid
ccsA	619507	c.-384A>G	upstream_gene_variant	0.45	capreomycin
					amikacin
					kanamycin
ccsA	619531	c.-360T>G	upstream_gene_variant	0.43	capreomycin
					amikacin
					kanamycin
ccsA	619535	c.-356_-355delCAinsGC	upstream_gene_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	619552	c.-339A>G	upstream_gene_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	619555	c.-336C>G	upstream_gene_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	619558	c.-333G>C	upstream_gene_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	619564	c.-327C>G	upstream_gene_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	619570	c.-321G>C	upstream_gene_variant	0.42	capreomycin
					amikacin
					kanamycin
ccsA	619574	c.-317G>A	upstream_gene_variant	0.37	capreomycin
					amikacin
					kanamycin
ccsA	619579	c.-312G>C	upstream_gene_variant	0.34	capreomycin
					amikacin
					kanamycin
ccsA	619591	c.-300G>C	upstream_gene_variant	0.33	capreomycin
					amikacin
					kanamycin
ccsA	619627	c.-264C>G	upstream_gene_variant	0.37	capreomycin
					amikacin
					kanamycin
ccsA	619634	c.-257T>A	upstream_gene_variant	0.36	capreomycin
					amikacin
					kanamycin
ccsA	619648	c.-243C>G	upstream_gene_variant	0.28	capreomycin
					amikacin
					kanamycin
ccsA	620245	c.355T>C	synonymous_variant	0.58	capreomycin
					amikacin
					kanamycin
ccsA	620249	p.Ser120Cys	missense_variant	0.58	capreomycin
					amikacin
					kanamycin
ccsA	620254	c.364_366delCTCinsTG	frameshift_variant&missense_variant	0.58	capreomycin
					amikacin
					kanamycin
ccsA	620257	p.Ile123Val	missense_variant	0.6	capreomycin
					amikacin
					kanamycin
ccsA	620265	c.375C>G	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620269	p.Val127Ile	missense_variant	0.67	capreomycin
					amikacin
					kanamycin
ccsA	620283	c.393T>C	synonymous_variant	0.67	capreomycin
					amikacin
					kanamycin
ccsA	620284	p.Ala132Pro	missense_variant	0.67	capreomycin
					amikacin
					kanamycin
ccsA	620288	p.Arg133Gln	missense_variant	0.67	capreomycin
					amikacin
					kanamycin
ccsA	620295	c.405G>C	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620307	c.417C>G	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620317	c.427_429delGTCinsCG	frameshift_variant&missense_variant	0.6	capreomycin
					amikacin
					kanamycin
ccsA	620322	c.432G>C	synonymous_variant	0.57	capreomycin
					amikacin
					kanamycin
ccsA	620340	c.450C>G	synonymous_variant	0.57	capreomycin
					amikacin
					kanamycin
ccsA	620349	c.459A>G	synonymous_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	620362	p.Ala158Thr	missense_variant	0.52	capreomycin
					amikacin
					kanamycin
ccsA	620367	c.477T>C	synonymous_variant	0.52	capreomycin
					amikacin
					kanamycin
ccsA	620373	c.483C>G	synonymous_variant	0.52	capreomycin
					amikacin
					kanamycin
ccsA	620385	c.495G>C	synonymous_variant	0.52	capreomycin
					amikacin
					kanamycin
ccsA	620388	c.498A>G	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620412	c.522T>C	synonymous_variant	0.48	capreomycin
					amikacin
					kanamycin
ccsA	620415	c.525T>C	synonymous_variant	0.48	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620433	c.543C>G	synonymous_variant	0.43	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620436	c.546T>C	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620439	c.549T>C	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620445	c.555A>G	synonymous_variant	0.43	capreomycin
					amikacin
					kanamycin
ccsA	620631	c.741T>C	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620646	c.756G>A	synonymous_variant	0.39	capreomycin
					amikacin
					kanamycin
ccsA	620661	c.771C>G	synonymous_variant	0.45	capreomycin
					amikacin
					kanamycin
ccsA	620703	c.813G>C	synonymous_variant	0.32	capreomycin
					amikacin
					kanamycin
ccsA	620710	c.820_822delGTGinsAC	frameshift_variant&missense_variant	0.3	capreomycin
					amikacin
					kanamycin
ccsA	620718	c.828G>C	synonymous_variant	0.3	capreomycin
					amikacin
					kanamycin
ccsA	620721	c.831G>C	synonymous_variant	0.32	capreomycin
					amikacin
					kanamycin
ccsA	620730	c.840C>T	synonymous_variant	0.32	capreomycin
					amikacin
					kanamycin
ccsA	620733	c.843G>C	synonymous_variant	0.32	capreomycin
					amikacin
					kanamycin
ccsA	620734	c.844C>A	synonymous_variant	0.32	capreomycin
					amikacin
					kanamycin
ccsA	620739	c.849A>G	synonymous_variant	0.32	capreomycin
					amikacin
					kanamycin
ccsA	620745	c.855G>C	synonymous_variant	0.33	capreomycin
					amikacin
					kanamycin
ccsA	620748	c.858T>A	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620778	c.888T>C	synonymous_variant	0.64	capreomycin
					amikacin
					kanamycin
ccsA	620784	c.894C>G	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620787	c.897C>G	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620809	c.919C>T	synonymous_variant	0.58	capreomycin
					amikacin
					kanamycin
Rv0565c	657269	p.Ser68Pro	missense_variant	0.84	ethionamide	Uncertain significance
Rv0565c	657602	c.-132C>G	upstream_gene_variant	0.25	ethionamide
Rv0565c	657632	c.-162G>A	upstream_gene_variant	0.28	ethionamide
Rv0565c	657639	c.-169C>G	upstream_gene_variant	0.28	ethionamide
Rv0565c	657641	c.-171C>G	upstream_gene_variant	0.28	ethionamide
Rv0565c	657649	c.-179G>A	upstream_gene_variant	0.39	ethionamide
Rv0565c	657678	c.-209_-208delAAinsGG	upstream_gene_variant	0.45	ethionamide
Rv0565c	657686	c.-216C>G	upstream_gene_variant	0.47	ethionamide
Rv0565c	657689	c.-220_-219delCAinsAG	upstream_gene_variant	0.48	ethionamide
Rv0565c	657701	c.-231C>G	upstream_gene_variant	0.57	ethionamide
Rv0565c	657719	c.-249C>G	upstream_gene_variant	0.57	ethionamide
Rv0565c	657734	c.-264T>C	upstream_gene_variant	0.56	ethionamide
hadA	731681	c.-249A>C	upstream_gene_variant	0.5	isoniazid
hadA	731687	c.-243_-242insCACGGATTTTTT	upstream_gene_variant	0.47	isoniazid
hadA	731690	c.-240A>C	upstream_gene_variant	0.47	isoniazid
hadA	731693	c.-237C>A	upstream_gene_variant	0.5	isoniazid
hadA	731696	c.-233_-232delTT	upstream_gene_variant	0.5	isoniazid
hadA	731701	c.-229A>G	upstream_gene_variant	0.5	isoniazid
hadA	731702	c.-228G>C	upstream_gene_variant	0.5	isoniazid
hadA	731708	c.-222G>C	upstream_gene_variant	0.5	isoniazid
hadA	731710	c.-220A>T	upstream_gene_variant	0.54	isoniazid
hadA	731711	c.-219T>C	upstream_gene_variant	0.54	isoniazid
hadA	731732	c.-198G>A	upstream_gene_variant	0.57	isoniazid
hadA	731741	c.-189G>A	upstream_gene_variant	0.57	isoniazid
hadA	731747	c.-183T>C	upstream_gene_variant	0.5	isoniazid
hadA	731753	c.-177A>G	upstream_gene_variant	0.57	isoniazid
hadA	732329	p.Leu134Val	missense_variant	0.47	isoniazid	Uncertain significance
hadA	732337	c.408G>A	synonymous_variant	0.47	isoniazid
hadA	732346	c.417T>C	synonymous_variant	0.56	isoniazid
hadA	732378	c.450_452dupAGA	disruptive_inframe_insertion	0.59	isoniazid
hadA	732389	p.Ser154Thr	missense_variant	0.6	isoniazid
hadA	732396	p.Gly156Ala	missense_variant	0.6	isoniazid
hadA	732398	p.Ala157Thr	missense_variant	0.6	isoniazid
nusG	734407	c.154_156delGTTinsAC	frameshift_variant&missense_variant	0.42	rifampicin
nusG	734421	c.168A>G	synonymous_variant	0.4	rifampicin
nusG	734424	c.171G>A	synonymous_variant	0.4	rifampicin
nusG	734442	c.189G>A	synonymous_variant	0.45	rifampicin
nusG	734457	c.204C>G	synonymous_variant	0.43	rifampicin
nusG	734472	c.219T>C	synonymous_variant	0.41	rifampicin
nusG	734475	c.222T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
nusG	734481	c.228C>G	synonymous_variant	0.48	rifampicin
nusG	734499	c.246G>C	synonymous_variant	0.48	rifampicin
nusG	734532	c.279A>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
nusG	734541	c.288A>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
nusG	734559	c.306T>C	synonymous_variant	0.62	rifampicin
nusG	734580	c.327T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
nusG	734595	c.342C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
nusG	734596	c.343T>C	synonymous_variant	0.58	rifampicin
nusG	734610	c.357C>G	synonymous_variant	0.56	rifampicin
nusG	734625	c.372T>C	synonymous_variant	0.52	rifampicin
nusG	734634	c.381G>C	synonymous_variant	0.54	rifampicin
nusG	734643	c.390G>C	synonymous_variant	0.56	rifampicin
nusG	734652	c.399T>C	synonymous_variant	0.56	rifampicin
nusG	734655	c.402G>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
nusG	734658	c.405A>G	synonymous_variant	0.54	rifampicin	Not assoc w R
nusG	734661	c.408A>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
nusG	734664	c.411T>G	synonymous_variant	0.58	rifampicin
nusG	734673	c.420A>G	synonymous_variant	0.58	rifampicin
nusG	734679	c.426C>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
nusG	734680	c.427_429delGCCinsTG	frameshift_variant&missense_variant	0.54	rifampicin
nusG	734703	c.450T>C	synonymous_variant	0.6	rifampicin
nusG	734709	c.456T>G	synonymous_variant	0.58	rifampicin
nusG	734715	c.462G>C	synonymous_variant	0.58	rifampicin
nusG	734718	c.465G>C	synonymous_variant	0.57	rifampicin
nusG	734719	p.Ser156Ala	missense_variant	0.57	rifampicin
nusG	734726	p.Arg158Lys	missense_variant	0.54	rifampicin
nusG	734732	p.Ala160Val	missense_variant	0.48	rifampicin
nusG	734754	c.501G>C	synonymous_variant	0.5	rifampicin
nusG	734757	c.504T>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
nusG	734778	c.525G>C	synonymous_variant	0.48	rifampicin
nusG	734781	c.528A>G	synonymous_variant	0.44	rifampicin
nusG	734792	p.Val180Ala	missense_variant	0.44	rifampicin
nusG	734794	p.Val181Ile	missense_variant	0.42	rifampicin	Uncertain significance
nusG	734820	c.567A>G	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
nusG	734826	c.573A>G	synonymous_variant	0.36	rifampicin
nusG	734829	c.576C>G	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
nusG	734832	c.579C>G	synonymous_variant	0.34	rifampicin
nusG	734841	c.588G>A	synonymous_variant	0.31	rifampicin
nusG	734847	c.594T>C	synonymous_variant	0.31	rifampicin
nusG	734853	c.600A>C	synonymous_variant	0.27	rifampicin
nusG	734854	c.601T>C	synonymous_variant	0.27	rifampicin
rpoB	760101	c.295T>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	760106	c.300G>T	synonymous_variant	0.32	rifampicin
rpoB	760112	c.306T>C	synonymous_variant	0.32	rifampicin
rpoB	760115	c.309C>T	synonymous_variant	0.68	rifampicin	Not assoc w R
rpoB	760118	c.312T>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	760121	c.315T>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoB	760130	p.Asp108Glu	missense_variant	0.42	rifampicin	Uncertain significance
rpoB	760139	c.333A>G	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoB	760142	c.336C>G	synonymous_variant	0.44	rifampicin
rpoB	760181	c.375T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760184	c.378A>G	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	760196	c.390C>G	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoB	760223	c.417T>C	synonymous_variant	0.72	rifampicin
rpoB	760235	c.429T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	760253	c.447T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	760283	c.477G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	760307	c.501T>C	synonymous_variant	0.8	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	0.74	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.75	rifampicin
rpoB	760337	c.531C>G	synonymous_variant	0.73	rifampicin
rpoB	760340	c.534G>C	synonymous_variant	0.74	rifampicin
rpoB	760361	c.555T>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	760376	p.Asp190Glu	missense_variant	0.71	rifampicin	Uncertain significance
rpoB	760406	c.600G>C	synonymous_variant	0.67	rifampicin
rpoB	760418	c.612G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	760424	c.618C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760475	c.669A>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760484	c.678A>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760522	p.Ser239Asn	missense_variant	0.6	rifampicin	Uncertain significance
rpoB	760532	c.726T>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243Thr	missense_variant	0.51	rifampicin
rpoB	760547	c.741G>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoB	760563	p.Arg253Met	missense_variant	0.53	rifampicin	Uncertain significance
rpoB	760591	p.Val262Ala	missense_variant	0.7	rifampicin
rpoB	760611	c.805T>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	760634	c.828T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoB	760646	c.840C>G	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoB	760655	c.849A>G	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoB	760661	c.855A>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	760670	c.864G>C	synonymous_variant	0.62	rifampicin
rpoB	760674	c.868T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760679	c.873A>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760683	c.877T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760718	c.912C>G	synonymous_variant	0.62	rifampicin
rpoB	760721	c.915C>G	synonymous_variant	0.6	rifampicin
rpoB	760724	c.918T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	760730	c.924T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	760751	c.945G>C	synonymous_variant	0.57	rifampicin
rpoB	760757	c.951T>C	synonymous_variant	0.52	rifampicin
rpoB	760759	p.Val318Ala	missense_variant	0.51	rifampicin
rpoB	760763	c.957C>T	synonymous_variant	0.51	rifampicin
rpoB	760769	c.963C>G	synonymous_variant	0.5	rifampicin
rpoB	760775	c.969G>C	synonymous_variant	0.5	rifampicin
rpoB	760776	c.970_972delTCGinsAGC	synonymous_variant	0.5	rifampicin
rpoB	760793	c.987A>G	synonymous_variant	0.54	rifampicin
rpoB	760805	c.999G>C	synonymous_variant	0.55	rifampicin
rpoB	760817	c.1011A>G	synonymous_variant	0.53	rifampicin
rpoB	760820	c.1014T>C	synonymous_variant	0.53	rifampicin
rpoB	760826	c.1020C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoB	760830	c.1024T>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	760845	p.Thr347Pro	missense_variant	0.62	rifampicin
rpoB	760859	c.1053T>C	synonymous_variant	0.64	rifampicin
rpoB	760862	c.1056G>C	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoB	760869	p.Val355Ile	missense_variant	0.65	rifampicin	Uncertain significance
rpoB	760886	c.1080A>G	synonymous_variant	0.69	rifampicin
rpoB	760919	c.1113C>G	synonymous_variant	0.75	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.75	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	760934	c.1128C>T	synonymous_variant	0.76	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	760970	c.1164G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	760982	c.1176G>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	760985	c.1179G>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	760991	c.1185G>C	synonymous_variant	0.8	rifampicin
rpoB	761015	c.1209G>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.88	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	761051	c.1245G>T	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	761054	c.1248G>A	synonymous_variant	0.88	rifampicin
rpoB	761057	c.1251G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	761060	c.1254C>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	761063	c.1257C>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	761097	c.1291_1292delAGinsTC	synonymous_variant	0.84	rifampicin
rpoB	761102	c.1296A>G	synonymous_variant	0.84	rifampicin
rpoB	761150	c.1344A>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761165	c.1359G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761168	c.1362C>G	synonymous_variant	0.8	rifampicin
rpoB	761171	c.1365C>T	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	761183	c.1377T>G	synonymous_variant	0.79	rifampicin
rpoB	761189	c.1383T>G	synonymous_variant	0.82	rifampicin
rpoB	761222	c.1416G>C	synonymous_variant	0.81	rifampicin
rpoB	761249	c.1443A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761255	c.1449T>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761297	c.1491C>T	synonymous_variant	0.77	rifampicin
rpoB	761327	c.1521A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	761360	c.1554T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761362	p.Ser519Thr	missense_variant	0.8	rifampicin
rpoB	761373	p.Val523His	missense_variant	0.83	rifampicin
rpoB	761414	c.1608A>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	761423	c.1617T>C	synonymous_variant	0.71	rifampicin
rpoB	761435	c.1629T>C	synonymous_variant	0.73	rifampicin
rpoB	761437	p.Ala544Asp	missense_variant	0.72	rifampicin
rpoB	761439	c.1633_1635delGACinsAG	frameshift_variant&missense_variant	0.72	rifampicin
rpoB	761444	c.1638T>C	synonymous_variant	0.72	rifampicin
rpoB	761447	c.1641C>G	synonymous_variant	0.69	rifampicin
rpoB	761452	p.Val549Ala	missense_variant	0.69	rifampicin
rpoB	761457	c.1651_1653delCCGinsGC	frameshift_variant&missense_variant	0.69	rifampicin
rpoB	761462	c.1656C>G	synonymous_variant	0.7	rifampicin
rpoB	761492	c.1686G>C	synonymous_variant	0.62	rifampicin
rpoB	761510	c.1704T>C	synonymous_variant	0.61	rifampicin
rpoB	761531	c.1725C>G	synonymous_variant	0.59	rifampicin
rpoB	761537	c.1731C>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	761570	c.1764T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	761606	c.1800C>G	synonymous_variant	0.49	rifampicin
rpoB	761612	c.1806G>C	synonymous_variant	0.49	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>G	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoB	761648	c.1842T>C	synonymous_variant	0.41	rifampicin
rpoB	761657	c.1851C>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	761675	c.1869G>C	synonymous_variant	0.44	rifampicin
rpoB	761690	c.1884G>C	synonymous_variant	0.43	rifampicin
rpoB	761723	c.1917_1919delAGAinsG	frameshift_variant&synonymous_variant	0.41	rifampicin
rpoB	761732	c.1926C>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	761735	c.1929C>G	synonymous_variant	0.44	rifampicin
rpoB	761747	c.1941G>C	synonymous_variant	0.49	rifampicin
rpoB	761750	c.1944G>C	synonymous_variant	0.47	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.48	rifampicin
rpoB	761768	c.1962G>T	synonymous_variant	0.48	rifampicin
rpoB	761772	p.His656Ala	missense_variant	0.47	rifampicin
rpoB	761778	p.Asn658Asp	missense_variant	0.46	rifampicin
rpoB	761791	p.Arg662His	missense_variant	0.45	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.48	rifampicin
rpoB	761815	p.Ala670Glu	missense_variant	0.49	rifampicin
rpoB	761834	c.2028T>C	synonymous_variant	0.52	rifampicin
rpoB	761847	p.Cys681Ser	missense_variant	0.53	rifampicin
rpoB	761852	c.2046C>G	synonymous_variant	0.55	rifampicin
rpoB	761858	c.2052G>C	synonymous_variant	0.52	rifampicin
rpoB	761864	c.2058G>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoB	761873	c.2067A>G	synonymous_variant	0.57	rifampicin
rpoB	761882	c.2076C>G	synonymous_variant	0.55	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.56	rifampicin
rpoB	761891	c.2085G>C	synonymous_variant	0.58	rifampicin
rpoB	761906	c.2100C>G	synonymous_variant	0.51	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	0.51	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	0.5	rifampicin
rpoB	761915	p.Asp703Glu	missense_variant	0.5	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	0.5	rifampicin
rpoB	761924	c.2118G>A	synonymous_variant	0.5	rifampicin
rpoB	761948	c.2142G>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoB	761954	c.2148C>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoB	761969	c.2163G>A	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	761999	c.2193G>C	synonymous_variant	0.57	rifampicin
rpoB	762008	c.2202C>G	synonymous_variant	0.57	rifampicin
rpoB	762014	c.2208C>T	synonymous_variant	0.58	rifampicin
rpoB	762017	c.2211A>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.6	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.58	rifampicin
rpoB	762140	c.2334G>C	synonymous_variant	0.58	rifampicin
rpoB	762143	c.2337T>C	synonymous_variant	0.59	rifampicin
rpoB	762149	c.2343G>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoB	762176	c.2370T>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	762218	c.2412T>G	synonymous_variant	0.63	rifampicin
rpoB	762254	c.2448T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	762266	c.2460T>C	synonymous_variant	0.7	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	762317	c.2511A>G	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	762329	c.2523G>C	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoB	762338	c.2532T>C	synonymous_variant	0.61	rifampicin
rpoB	762347	c.2541T>C	synonymous_variant	0.61	rifampicin
rpoB	762362	p.Glu852Asp	missense_variant	0.57	rifampicin
rpoB	762369	c.2563T>C	synonymous_variant	0.55	rifampicin
rpoC	762374	c.-996G>C	upstream_gene_variant	0.53	rifampicin
rpoC	762380	c.-990T>G	upstream_gene_variant	0.55	rifampicin
rpoC	762395	c.-975G>C	upstream_gene_variant	0.52	rifampicin
rpoC	762398	c.-972T>C	upstream_gene_variant	0.52	rifampicin
rpoC	762401	c.-969G>C	upstream_gene_variant	0.54	rifampicin
rpoB	762404	c.2598T>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoC	762410	c.-960T>C	upstream_gene_variant	0.5	rifampicin
rpoB	762416	c.2610A>G	synonymous_variant	0.49	rifampicin	Not assoc w R - Interim
rpoC	762443	c.-927G>T	upstream_gene_variant	0.43	rifampicin
rpoB	762470	c.2664G>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoB	762489	p.Val895Gln	missense_variant	0.32	rifampicin
rpoC	762509	c.-861T>G	upstream_gene_variant	0.28	rifampicin
rpoC	762521	c.-849C>G	upstream_gene_variant	0.3	rifampicin
rpoC	762533	c.-837T>C	upstream_gene_variant	0.29	rifampicin
rpoC	762536	c.-834T>C	upstream_gene_variant	0.3	rifampicin
rpoC	762537	c.-833T>C	upstream_gene_variant	0.3	rifampicin
rpoC	762551	c.-819C>T	upstream_gene_variant	0.28	rifampicin
rpoB	762782	c.2976T>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	762785	p.Asp993Glu	missense_variant	0.3	rifampicin	Uncertain significance
rpoB	762788	c.2982G>C	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	762789	p.Leu995Met	missense_variant	0.3	rifampicin	Uncertain significance
rpoC	762794	c.-576C>G	upstream_gene_variant	0.33	rifampicin
rpoB	762799	p.Ala998Gly	missense_variant	0.33	rifampicin	Uncertain significance
rpoB	762812	c.3006C>G	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoB	762813	p.Met1003Val	missense_variant	0.35	rifampicin
rpoB	762818	c.3012C>G	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoB	762827	c.3021G>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	762830	c.3024C>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	762831	c.3025_3026delAGinsTC	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	762836	c.-534C>G	upstream_gene_variant	0.36	rifampicin
rpoB	762857	c.3051C>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	762860	c.3054G>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	762863	c.3057T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	762989	c.-381G>C	upstream_gene_variant	0.71	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	763028	c.3222T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	763034	c.3228C>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	763076	c.-294C>G	upstream_gene_variant	0.79	rifampicin
rpoB	763085	c.3279C>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763148	c.-222G>C	upstream_gene_variant	0.52	rifampicin
rpoC	763158	c.-212C>T	upstream_gene_variant	0.48	rifampicin
rpoB	763166	c.3360A>G	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoC	763169	c.-201A>G	upstream_gene_variant	0.4	rifampicin
rpoC	763202	c.-168A>C	upstream_gene_variant	0.37	rifampicin
rpoC	763205	c.-165G>C	upstream_gene_variant	0.37	rifampicin
rpoC	763206	c.-164_-162delAGTinsTCC	upstream_gene_variant	0.37	rifampicin
rpoB	763214	c.3408T>C	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoC	763226	c.-144A>G	upstream_gene_variant	0.46	rifampicin
rpoB	763238	c.3432T>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoB	763268	c.3462C>G	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	763283	c.3477T>C	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoC	763284	c.-86C>T	upstream_gene_variant	0.4	rifampicin
rpoB	763316	c.3510T>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	763319	c.-51T>G	upstream_gene_variant	0.36	rifampicin
rpoC	763322	c.-48G>T	upstream_gene_variant	0.35	rifampicin
rpoC	763325	c.-44_-37delAGCTGTCG	upstream_gene_variant	0.36	rifampicin
rpoC	763335	c.-35A>C	upstream_gene_variant	0.35	rifampicin
rpoC	763338	c.-32A>C	upstream_gene_variant	0.33	rifampicin
rpoC	763340	c.-30_-29insTTTCACTA	upstream_gene_variant	0.32	rifampicin
rpoC	763343	c.-27T>C	upstream_gene_variant	0.32	rifampicin
rpoC	763351	c.-19T>C	upstream_gene_variant	0.32	rifampicin	Uncertain significance
rpoC	763352	c.-18T>A	upstream_gene_variant	0.32	rifampicin	Uncertain significance
rpoC	763402	c.33C>G	synonymous_variant	0.44	rifampicin
rpoC	763411	c.42T>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	763414	c.45T>C	synonymous_variant	0.42	rifampicin
rpoC	763441	c.72C>G	synonymous_variant	0.42	rifampicin
rpoC	763444	c.75T>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	763468	c.99G>C	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoC	763486	c.117T>C	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoC	763528	c.159G>A	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	763633	c.264T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	763636	c.267T>C	synonymous_variant	0.66	rifampicin
rpoC	763642	c.273G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763658	c.289_291delCTTinsTG	frameshift_variant&missense_variant	0.67	rifampicin
rpoC	763675	c.306C>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	763696	c.327T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	763702	c.333C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	763708	c.339G>A	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763709	c.340C>T	synonymous_variant	0.67	rifampicin
rpoC	763714	c.345G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763717	c.348T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763723	c.354G>C	synonymous_variant	0.69	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.68	rifampicin
rpoC	763735	c.366G>C	synonymous_variant	0.67	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.72	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	0.72	rifampicin
rpoC	763768	c.399C>G	synonymous_variant	0.72	rifampicin
rpoC	763780	c.411C>G	synonymous_variant	0.75	rifampicin
rpoC	763783	c.414G>C	synonymous_variant	0.75	rifampicin
rpoC	763801	c.432C>G	synonymous_variant	0.8	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	763819	c.450G>C	synonymous_variant	0.8	rifampicin
rpoC	763831	c.462A>G	synonymous_variant	0.79	rifampicin
rpoC	763835	p.Ala156Met	missense_variant	0.77	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.81	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.8	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	0.81	rifampicin
rpoC	763879	c.510A>G	synonymous_variant	0.81	rifampicin
rpoC	763888	c.519G>C	synonymous_variant	0.82	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	0.8	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	0.82	rifampicin
rpoC	763919	c.550C>T	synonymous_variant	0.8	rifampicin
rpoC	763933	c.564C>T	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	763945	c.576T>C	synonymous_variant	0.81	rifampicin
rpoC	763960	c.591T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	763967	p.Gly200Ser	missense_variant	0.83	rifampicin
rpoC	763978	c.609C>G	synonymous_variant	0.79	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.77	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	764011	c.642T>C	synonymous_variant	0.83	rifampicin
rpoC	764024	c.655T>C	synonymous_variant	0.75	rifampicin
rpoC	764040	p.Ser224Asn	missense_variant	0.69	rifampicin
rpoC	764044	c.675T>C	synonymous_variant	0.68	rifampicin
rpoC	764059	c.690G>C	synonymous_variant	0.66	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.66	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	764131	c.762T>C	synonymous_variant	0.71	rifampicin
rpoC	764161	c.792G>C	synonymous_variant	0.72	rifampicin
rpoC	764188	c.819A>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	764195	p.Ser276Gln	missense_variant	0.68	rifampicin
rpoC	764203	c.834G>T	synonymous_variant	0.65	rifampicin
rpoC	764206	c.837T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	764257	c.888G>C	synonymous_variant	0.66	rifampicin
rpoC	764263	c.894G>A	synonymous_variant	0.39	rifampicin	Not assoc w R
rpoC	764266	c.897T>C	synonymous_variant	0.63	rifampicin
rpoC	764269	c.900G>C	synonymous_variant	0.68	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	764282	c.913_915delTCGinsAGC	synonymous_variant	0.63	rifampicin
rpoC	764320	c.951C>G	synonymous_variant	0.66	rifampicin
rpoC	764365	c.996C>T	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoC	764380	c.1011G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	764381	c.1012_1013delTCinsAG	synonymous_variant	0.65	rifampicin
rpoC	764387	c.1018_1020delTTGinsCC	frameshift_variant&missense_variant	0.65	rifampicin
rpoC	764405	c.1036A>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	0.61	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.59	rifampicin
rpoC	764455	c.1086G>C	synonymous_variant	0.59	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoC	764497	c.1128A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	764521	c.1152T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	764530	c.1161C>G	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	764536	c.1167G>C	synonymous_variant	0.69	rifampicin
rpoC	764539	c.1170C>G	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	764560	c.1191T>C	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoC	764566	c.1197C>G	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	764573	c.1204_1206delCTTinsTG	frameshift_variant&missense_variant	0.63	rifampicin
rpoC	764576	c.1207_1208delTCinsAG	synonymous_variant	0.58	rifampicin
rpoC	764581	c.1212T>C	synonymous_variant	0.61	rifampicin
rpoC	764626	c.1257C>T	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoC	764632	c.1263T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	764644	c.1275G>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>T	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	764714	c.1345C>T	synonymous_variant	0.65	rifampicin
rpoC	764720	c.1351C>T	synonymous_variant	0.68	rifampicin
rpoC	764752	c.1383G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	764791	c.1422C>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	764809	c.1440C>T	synonymous_variant	0.39	rifampicin	Not assoc w R
rpoC	764812	c.1443C>G	synonymous_variant	0.38	rifampicin
rpoC	764815	c.1446A>G	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	764824	c.1455T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	764830	c.1461C>G	synonymous_variant	0.4	rifampicin
rpoC	764858	c.1489T>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoC	764872	c.1503A>G	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	764893	c.1524T>C	synonymous_variant	0.33	rifampicin
rpoC	764911	c.1542A>G	synonymous_variant	0.35	rifampicin
rpoC	764923	c.1554A>G	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	764932	c.1563C>A	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	764995	c.1626C>G	synonymous_variant	0.32	rifampicin	Not assoc w R
rpoC	765007	c.1638T>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	765019	c.1650A>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	765022	c.1653G>C	synonymous_variant	0.28	rifampicin
rpoC	765034	c.1665T>C	synonymous_variant	0.31	rifampicin
rpoC	765040	c.1671T>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	765041	c.1672T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	765047	c.1678T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	765103	c.1734G>A	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765150	p.Gly594Glu	missense_variant	0.88	rifampicin	Not assoc w R
rpoC	765298	c.1929G>C	synonymous_variant	0.57	rifampicin
rpoC	765300	p.Val644Ala	missense_variant	0.57	rifampicin	Uncertain significance
rpoC	765319	c.1950A>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	765326	p.His653Ala	missense_variant	0.68	rifampicin	Uncertain significance
rpoC	765330	p.Ser654Asn	missense_variant	0.68	rifampicin	Uncertain significance
rpoC	765349	c.1980T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765352	c.1983G>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	765383	p.Met672Leu	missense_variant	0.69	rifampicin	Uncertain significance
rpoC	765404	p.Leu679Val	missense_variant	0.69	rifampicin
rpoC	765409	c.2040T>C	synonymous_variant	0.66	rifampicin
rpoC	765412	c.2043T>C	synonymous_variant	0.68	rifampicin
rpoC	765421	c.2052C>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	765451	c.2082C>G	synonymous_variant	0.63	rifampicin
rpoC	765452	c.2083_2085delGCCinsTG	frameshift_variant&missense_variant	0.62	rifampicin
rpoC	765478	c.2109T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	765508	c.2139C>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	765517	c.2148C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	765541	c.2172C>G	synonymous_variant	0.59	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	0.58	rifampicin
rpoC	765559	c.2190G>C	synonymous_variant	0.58	rifampicin
rpoC	765578	c.2209C>T	synonymous_variant	0.56	rifampicin
rpoC	765583	c.2214G>T	synonymous_variant	0.57	rifampicin
rpoC	765613	p.His748Gln	missense_variant	0.58	rifampicin
rpoC	765625	c.2256C>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	765628	c.2259G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	765631	p.Asp754Glu	missense_variant	0.64	rifampicin
rpoC	765658	c.2289C>T	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	765700	c.2331T>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	765734	c.2365T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765739	c.2370G>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	765751	c.2382C>G	synonymous_variant	0.81	rifampicin
rpoC	765753	p.Asp795Ala	missense_variant	0.82	rifampicin	Uncertain significance
rpoC	765772	c.2403C>G	synonymous_variant	0.84	rifampicin
rpoC	765784	c.2415C>G	synonymous_variant	0.84	rifampicin
rpoC	765796	c.2427C>T	synonymous_variant	0.79	rifampicin
rpoC	765811	c.2442T>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	765814	c.2445A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	765826	c.2457T>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	0.72	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	0.72	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	765928	c.2559C>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	765967	c.2598C>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765970	c.2601C>T	synonymous_variant	0.7	rifampicin
rpoC	765979	c.2610C>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	765982	c.2613C>T	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	765985	c.2616C>T	synonymous_variant	0.66	rifampicin
rpoC	765994	c.2625A>T	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoC	766009	c.2640G>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	766010	c.2641_2642delTCinsAG	synonymous_variant	0.58	rifampicin
rpoC	766021	c.2652G>C	synonymous_variant	0.58	rifampicin
rpoC	766043	p.Gln892Glu	missense_variant	0.51	rifampicin
rpoC	766054	c.2685C>G	synonymous_variant	0.47	rifampicin
rpoC	766069	c.2700G>A	synonymous_variant	0.44	rifampicin
rpoC	766082	p.Ala905Gln	missense_variant	0.42	rifampicin
rpoC	766096	c.2727G>C	synonymous_variant	0.47	rifampicin
rpoC	766105	c.2736C>T	synonymous_variant	0.44	rifampicin
rpoC	766129	c.2760C>G	synonymous_variant	0.39	rifampicin
rpoC	766135	c.2766G>A	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	766141	c.2772C>T	synonymous_variant	0.38	rifampicin
rpoC	766142	c.2773C>T	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	766185	p.Glu939Ala	missense_variant	0.24	rifampicin
rpoC	766189	c.2820T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	766192	c.2823T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	766193	p.Gln942Glu	missense_variant	0.24	rifampicin
rpoC	766204	c.2835C>T	synonymous_variant	0.21	rifampicin
rpoC	766234	c.2865T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	766237	c.2868T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	766244	p.Gln959Ser	missense_variant	0.24	rifampicin
rpoC	766258	c.2889T>C	synonymous_variant	0.3	rifampicin
rpoC	766270	c.2901G>C	synonymous_variant	0.29	rifampicin
rpoC	766273	c.2904T>C	synonymous_variant	0.29	rifampicin
rpoC	766274	p.Ala969Thr	missense_variant	0.29	rifampicin
rpoC	766279	c.2910C>G	synonymous_variant	0.28	rifampicin
rpoC	766280	p.Ser971Gly	missense_variant	0.28	rifampicin
rpoC	766309	c.2940G>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	766312	c.2943T>G	synonymous_variant	0.35	rifampicin
rpoC	766315	c.2946C>G	synonymous_variant	0.35	rifampicin
rpoC	766327	c.2958C>G	synonymous_variant	0.41	rifampicin
rpoC	766345	c.2976T>C	synonymous_variant	0.44	rifampicin
rpoC	766348	c.2979A>G	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	766363	c.2994G>C	synonymous_variant	0.48	rifampicin
rpoC	766381	c.3012C>T	synonymous_variant	0.48	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	0.5	rifampicin
rpoC	766390	c.3021C>T	synonymous_variant	0.5	rifampicin
rpoC	766408	c.3039C>T	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoC	766426	c.3057C>T	synonymous_variant	0.59	rifampicin
rpoC	766444	c.3075C>G	synonymous_variant	0.59	rifampicin
rpoC	766447	c.3078T>C	synonymous_variant	0.61	rifampicin
rpoC	766483	c.3114G>C	synonymous_variant	0.64	rifampicin
rpoC	766484	c.3115_3117delGTAinsAC	frameshift_variant&missense_variant	0.62	rifampicin
rpoC	766492	c.3123T>C	synonymous_variant	0.64	rifampicin
rpoC	766495	c.3126C>T	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	766528	c.3159T>G	synonymous_variant	0.76	rifampicin
rpoC	766543	c.3174C>T	synonymous_variant	0.79	rifampicin
rpoC	766573	c.3204T>C	synonymous_variant	0.77	rifampicin
rpoC	766583	c.3214_3216delGGTinsAC	frameshift_variant&missense_variant	0.76	rifampicin
rpoC	766591	c.3222A>G	synonymous_variant	0.76	rifampicin
rpoC	766594	c.3225G>C	synonymous_variant	0.76	rifampicin
rpoC	766597	c.3228C>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	766607	c.3238_3240delATCinsCG	frameshift_variant&missense_variant	0.76	rifampicin
rpoC	766630	c.3261G>C	synonymous_variant	0.77	rifampicin
rpoC	766645	c.3276A>G	synonymous_variant	0.74	rifampicin
rpoC	766651	c.3282T>C	synonymous_variant	0.71	rifampicin
rpoC	766657	c.3288A>G	synonymous_variant	0.69	rifampicin
rpoC	766672	c.3303T>C	synonymous_variant	0.64	rifampicin
rpoC	766738	c.3369G>T	synonymous_variant	0.74	rifampicin
rpoC	766750	c.3381C>G	synonymous_variant	0.74	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	766769	c.3400C>T	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	0.77	rifampicin
rpoC	766801	c.3432C>G	synonymous_variant	0.77	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	766861	c.3492G>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.71	rifampicin
rpoC	766894	c.3525T>C	synonymous_variant	0.71	rifampicin
rpoC	766895	c.3526T>C	synonymous_variant	0.71	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.74	rifampicin
rpoC	766933	c.3564A>G	synonymous_variant	0.76	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	766963	c.3594T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	766972	c.3603G>C	synonymous_variant	0.74	rifampicin
rpoC	766978	c.3609C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	766996	c.3627C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	767009	c.3640_3642delTCGinsAGC	synonymous_variant	0.74	rifampicin
rpoC	767014	c.3645G>C	synonymous_variant	0.74	rifampicin
rpoC	767033	c.3664_3666delTCGinsAGC	synonymous_variant	0.72	rifampicin
rpoC	767059	c.3690T>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.75	rifampicin
rpoC	767074	c.3705T>C	synonymous_variant	0.76	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>G	synonymous_variant	0.78	rifampicin
rpoC	767158	c.3789T>G	synonymous_variant	0.71	rifampicin
rpoC	767167	c.3798C>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.7	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	767206	c.3837C>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	767209	c.3840T>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	767212	c.3843G>C	synonymous_variant	0.57	rifampicin
rpoC	767221	c.3852C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	767230	c.3861G>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	767233	c.3864T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	767263	c.3894T>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	767264	p.Ala1299Gln	missense_variant	0.47	rifampicin
rpoC	767275	c.3906T>C	synonymous_variant	0.5	rifampicin
rpoC	767278	c.3909T>C	synonymous_variant	0.5	rifampicin
rpoC	767281	c.3912C>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	767284	c.3915C>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
mmpL5	775975	c.2506T>C	synonymous_variant	0.44	clofazimine
mmpL5	775975	c.2506T>C	synonymous_variant	0.44	bedaquiline
mmpL5	775981	p.Leu834Met	missense_variant	0.42	clofazimine
mmpL5	775981	p.Leu834Met	missense_variant	0.42	bedaquiline
mmpL5	775997	c.2484T>C	synonymous_variant	0.42	clofazimine
mmpL5	775997	c.2484T>C	synonymous_variant	0.42	bedaquiline
mmpL5	776009	c.2472A>G	synonymous_variant	0.47	clofazimine
mmpL5	776009	c.2472A>G	synonymous_variant	0.47	bedaquiline
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rpsL	781631	c.72G>C	synonymous_variant	0.36	streptomycin
rpsL	781649	c.90T>C	synonymous_variant	0.46	streptomycin
rpsL	781655	c.96T>C	synonymous_variant	0.47	streptomycin
rpsL	781682	c.123T>C	synonymous_variant	0.45	streptomycin
rpsL	781715	c.156T>C	synonymous_variant	0.46	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	0.48	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	0.5	streptomycin
rpsL	781751	c.192G>C	synonymous_variant	0.53	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	0.54	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	0.54	streptomycin
rpsL	781793	c.234G>C	synonymous_variant	0.55	streptomycin
rpsL	781832	c.273T>C	synonymous_variant	0.6	streptomycin
rpsL	781841	c.282C>G	synonymous_variant	0.59	streptomycin
rpsL	781859	c.300T>C	synonymous_variant	0.53	streptomycin	Not assoc w R - Interim
rpsL	781868	c.309T>C	synonymous_variant	0.52	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	0.51	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	0.49	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.49	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	0.51	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.54	streptomycin	Uncertain significance
rplC	800200	c.-609C>G	upstream_gene_variant	1.0	linezolid
rplC	800516	c.-293G>T	upstream_gene_variant	0.3	linezolid
rplC	800537	c.-272C>T	upstream_gene_variant	0.38	linezolid
rplC	800540	c.-269T>C	upstream_gene_variant	0.38	linezolid
rplC	800546	c.-263T>C	upstream_gene_variant	0.38	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.41	linezolid
rplC	800582	c.-227C>G	upstream_gene_variant	0.48	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.59	linezolid
rplC	800618	c.-191T>C	upstream_gene_variant	0.59	linezolid
rplC	800648	c.-161A>C	upstream_gene_variant	0.68	linezolid
rplC	800654	c.-155T>C	upstream_gene_variant	0.68	linezolid
rplC	800690	c.-119C>T	upstream_gene_variant	0.7	linezolid
rplC	800693	c.-116A>G	upstream_gene_variant	0.7	linezolid
rplC	800703	c.-106T>C	upstream_gene_variant	0.73	linezolid
rplC	800715	c.-94A>C	upstream_gene_variant	0.71	linezolid
rplC	800720	c.-89T>C	upstream_gene_variant	0.73	linezolid
rplC	800723	c.-86C>G	upstream_gene_variant	0.71	linezolid
rplC	800738	c.-71T>C	upstream_gene_variant	0.71	linezolid
rplC	800747	c.-62C>G	upstream_gene_variant	0.65	linezolid
rplC	800771	c.-38C>T	upstream_gene_variant	0.61	linezolid
rplC	800794	c.-15_-9delAGATTGGinsGAGTT	upstream_gene_variant	0.61	linezolid
rplC	800814	c.6A>G	synonymous_variant	0.59	linezolid
rplC	800817	c.9A>T	synonymous_variant	0.59	linezolid
rplC	800844	c.36T>C	synonymous_variant	0.5	linezolid
rplC	800865	c.57A>G	synonymous_variant	0.52	linezolid
rplC	800867	p.Ser20Asn	missense_variant	0.52	linezolid
rplC	800874	c.66A>G	synonymous_variant	0.56	linezolid
rplC	800877	c.69A>C	synonymous_variant	0.54	linezolid
rplC	800880	c.72A>G	synonymous_variant	0.54	linezolid
rplC	800889	c.81C>G	synonymous_variant	0.59	linezolid
rplC	800907	c.99C>G	synonymous_variant	0.52	linezolid
rplC	800916	c.108A>G	synonymous_variant	0.54	linezolid
rplC	800937	c.129A>G	synonymous_variant	0.48	linezolid
rplC	800939	p.Arg44Gln	missense_variant	0.46	linezolid
rplC	800946	c.138T>C	synonymous_variant	0.46	linezolid
rplC	800949	c.141T>C	synonymous_variant	0.46	linezolid
rplC	800955	c.147C>G	synonymous_variant	0.48	linezolid
rplC	800967	c.159C>G	synonymous_variant	0.47	linezolid
rplC	800970	c.162T>C	synonymous_variant	0.45	linezolid	Not assoc w R - Interim
rplC	800982	c.174C>T	synonymous_variant	0.41	linezolid
rplC	800985	c.177A>G	synonymous_variant	0.41	linezolid
rplC	800994	c.186C>G	synonymous_variant	0.36	linezolid
rplC	801004	p.Leu66Val	missense_variant	0.35	linezolid
rplC	801009	c.201A>C	synonymous_variant	0.35	linezolid
rplC	801012	c.204T>C	synonymous_variant	0.37	linezolid
rplC	801019	p.Thr71Ala	missense_variant	0.35	linezolid
rplC	801024	c.216C>G	synonymous_variant	0.35	linezolid
rplC	801027	c.219C>G	synonymous_variant	0.32	linezolid
rplC	801031	p.Val75Ile	missense_variant	0.31	linezolid
rplC	801039	c.231A>G	synonymous_variant	0.3	linezolid
rplC	801045	c.237A>C	synonymous_variant	0.3	linezolid
rplC	801047	p.Tyr80Phe	missense_variant	0.3	linezolid
rplC	801054	c.246G>C	synonymous_variant	0.3	linezolid
rplC	801070	p.Asp88Asn	missense_variant	0.27	linezolid
rplC	801085	p.Thr93Ala	missense_variant	0.25	linezolid	Uncertain significance
rplC	801090	c.282G>A	synonymous_variant	0.29	linezolid
rplC	801099	c.291T>C	synonymous_variant	0.28	linezolid
rplC	801102	c.294G>C	synonymous_variant	0.28	linezolid
rplC	801105	c.297A>G	synonymous_variant	0.29	linezolid
rplC	801109	c.301T>C	synonymous_variant	0.29	linezolid	Not assoc w R - Interim
rplC	801114	c.306C>G	synonymous_variant	0.31	linezolid
rplC	801127	p.Ala107Thr	missense_variant	0.32	linezolid
rplC	801132	c.324T>C	synonymous_variant	0.33	linezolid
rplC	801147	c.339T>C	synonymous_variant	0.4	linezolid
rplC	801150	c.342G>C	synonymous_variant	0.4	linezolid
rplC	801153	c.345G>C	synonymous_variant	0.4	linezolid
rplC	801156	c.348T>A	synonymous_variant	0.4	linezolid
rplC	801171	c.363A>G	synonymous_variant	0.46	linezolid
rplC	801174	c.366T>C	synonymous_variant	0.47	linezolid
rplC	801222	c.414T>C	synonymous_variant	0.48	linezolid
rplC	801228	c.420T>C	synonymous_variant	0.5	linezolid
rplC	801246	c.438C>G	synonymous_variant	0.54	linezolid
rplC	801249	c.441T>G	synonymous_variant	0.52	linezolid
rplC	801255	c.447C>T	synonymous_variant	0.55	linezolid
rplC	801267	c.459A>T	synonymous_variant	0.45	linezolid
rplC	801348	c.540T>G	synonymous_variant	0.33	linezolid
rplC	801357	c.549T>C	synonymous_variant	0.34	linezolid
rplC	801367	p.Ala187Thr	missense_variant	0.35	linezolid
rplC	801396	c.588T>C	synonymous_variant	0.38	linezolid
rplC	801402	c.594T>C	synonymous_variant	0.38	linezolid
rplC	801405	c.597T>C	synonymous_variant	0.35	linezolid
rplC	801417	c.609T>C	synonymous_variant	0.32	linezolid
rplC	801423	c.615G>C	synonymous_variant	0.31	linezolid
rplC	801438	c.630T>C	synonymous_variant	0.3	linezolid
rplC	801442	p.Ile212Val	missense_variant	0.26	linezolid
rplC	801461	c.653G>A	splice_region_variant&stop_retained_variant	0.23	linezolid
Rv1129c	1253097	p.Ser480Pro	missense_variant	1.0	moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
fbiC	1303464	c.534A>G	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fbiC	1303470	c.540T>G	synonymous_variant	0.32	clofazimine
					pretomanid
					delamanid
fbiC	1303476	c.546G>C	synonymous_variant	0.31	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1303509	c.579G>C	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fbiC	1303512	c.582T>C	synonymous_variant	0.36	clofazimine
					pretomanid
					delamanid
fbiC	1303534	p.Ser202Ala	missense_variant	0.37	clofazimine
					pretomanid
					delamanid
fbiC	1303545	c.615A>G	synonymous_variant	0.39	clofazimine
					pretomanid
					delamanid
fbiC	1303560	c.630G>C	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1303575	c.645G>C	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1303584	c.654C>G	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1303590	c.660A>G	synonymous_variant	0.51	clofazimine
					pretomanid
					delamanid
fbiC	1303602	c.672A>G	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1303605	c.675C>G	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1303608	c.678G>A	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1303611	c.681G>C	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1303614	c.684C>T	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fbiC	1303617	c.687C>G	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1303632	c.702T>G	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fbiC	1303638	c.708A>G	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1303659	c.729T>C	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1303660	p.Val244Thr	missense_variant	0.39	clofazimine
					pretomanid
					delamanid
fbiC	1303674	c.744C>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1303686	c.756C>G	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1303695	c.765T>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1303701	c.771C>G	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1303708	c.778T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1303716	c.786C>T	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1303728	c.798G>A	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1303731	c.801A>C	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1303732	p.Ser268Ala	missense_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1303737	c.807G>A	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1303746	c.816T>C	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1303749	c.819G>C	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1303752	c.822A>G	synonymous_variant	0.47	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1303755	c.825T>C	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1303785	c.855G>C	synonymous_variant	0.51	clofazimine
					pretomanid
					delamanid
fbiC	1303818	c.888C>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1303836	c.906G>C	synonymous_variant	0.57	clofazimine
					pretomanid
					delamanid
fbiC	1303845	c.915C>G	synonymous_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1303846	p.Phe306Val	missense_variant	0.55	clofazimine
					pretomanid
					delamanid
fbiC	1303854	c.924T>C	synonymous_variant	0.57	clofazimine
					pretomanid
					delamanid
fbiC	1303860	c.930A>C	synonymous_variant	0.57	clofazimine
					pretomanid
					delamanid
fbiC	1303881	c.951G>C	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1303884	c.954T>G	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1303911	c.981G>C	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1303914	c.984C>G	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1303920	c.990C>G	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1303923	c.993C>T	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1303929	c.999G>C	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1303947	c.1017T>C	synonymous_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1303948	p.Gly340Arg	missense_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1303973	p.Gly348Ala	missense_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1303981	p.Val351Ile	missense_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1303995	c.1065C>T	synonymous_variant	0.62	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304001	c.1071C>G	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304008	c.1078T>C	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1304034	c.1104A>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304040	c.1110C>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304046	c.1116C>G	synonymous_variant	0.55	clofazimine
					pretomanid
					delamanid
fbiC	1304049	c.1119T>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304058	c.1128G>A	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304059	c.1129C>T	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1304064	c.1134G>C	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304067	c.1137G>C	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304080	p.Ala384Ser	missense_variant	0.48	clofazimine
					pretomanid
					delamanid
fbiC	1304091	p.Asp387Glu	missense_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304092	p.Met388Leu	missense_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304097	c.1167G>C	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304115	c.1185A>G	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304127	c.1197A>G	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1304565	c.1635C>G	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304568	c.1638T>C	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304574	c.1644C>G	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1304580	c.1650T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304613	c.1683T>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1304628	c.1698G>C	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fbiC	1304634	c.1704C>G	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304640	c.1710A>C	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1304646	c.1716T>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1304658	c.1728C>G	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1304670	c.1740G>T	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1304671	p.Val581Thr	missense_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1304675	p.Gly582Glu	missense_variant	0.57	clofazimine
					pretomanid
					delamanid
fbiC	1304691	c.1761G>C	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304694	c.1764A>C	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304703	c.1773C>G	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304715	c.1785G>C	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1304724	c.1794A>G	synonymous_variant	0.6	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304727	c.1797A>G	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1304742	c.1812T>C	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1304748	c.1818T>C	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304754	c.1824G>A	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304757	c.1827A>G	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1304784	c.1854T>C	synonymous_variant	0.64	clofazimine
					pretomanid
					delamanid
fbiC	1304787	c.1857T>C	synonymous_variant	0.64	clofazimine
					pretomanid
					delamanid
fbiC	1304790	c.1860C>G	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1304808	c.1878C>G	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304811	c.1881C>G	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304817	c.1887T>C	synonymous_variant	0.57	clofazimine
					pretomanid
					delamanid
fbiC	1304829	c.1899T>C	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304832	c.1902C>G	synonymous_variant	0.5	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304853	c.1923C>G	synonymous_variant	0.5	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304856	c.1926C>G	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fbiC	1304872	c.1942_1944delAGCinsTCG	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304877	c.1947T>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304893	p.Gly655Ser	missense_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304916	c.1986T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304925	c.1995G>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304928	c.1998T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304934	c.2004C>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304937	c.2007G>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304940	c.2010A>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304946	c.2016G>C	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1304958	c.2028T>G	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304961	c.2031C>T	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1304991	c.2061G>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304994	c.2064A>G	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1304995	c.2065T>C	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1305006	c.2076A>G	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1305012	c.2082G>C	synonymous_variant	0.39	clofazimine
					pretomanid
					delamanid
fbiC	1305015	c.2085G>C	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1305021	c.2091C>A	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fbiC	1305027	c.2097G>A	synonymous_variant	0.3	clofazimine
					pretomanid
					delamanid
fbiC	1305033	c.2103T>G	synonymous_variant	0.28	clofazimine
					pretomanid
					delamanid
fbiC	1305042	c.2112A>G	synonymous_variant	0.27	clofazimine
					pretomanid
					delamanid
fbiC	1305126	c.2196T>C	synonymous_variant	0.36	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1305135	c.2205C>T	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fbiC	1305276	c.2346G>C	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1305279	p.His783Gln	missense_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1305282	c.2352T>C	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1305297	c.2367G>C	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1305300	c.2370A>G	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1305303	c.2373T>C	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1305306	c.2376A>T	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1305311	p.Arg794Gln	missense_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1305336	c.2406T>C	synonymous_variant	0.42	clofazimine
					pretomanid
					delamanid
fbiC	1305381	c.2451G>C	synonymous_variant	0.32	clofazimine
					pretomanid
					delamanid
sigE	1364676	c.264C>G	synonymous_variant	0.35	pyrazinamide
sigE	1364679	c.267T>C	synonymous_variant	0.35	pyrazinamide
sigE	1364691	c.279T>C	synonymous_variant	0.41	pyrazinamide
sigE	1364712	c.300T>C	synonymous_variant	0.48	pyrazinamide
sigE	1364718	c.306C>T	synonymous_variant	0.48	pyrazinamide
sigE	1364727	c.315C>T	synonymous_variant	0.5	pyrazinamide
sigE	1364736	c.324T>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
sigE	1364742	c.330A>G	synonymous_variant	0.54	pyrazinamide
sigE	1364748	c.336G>C	synonymous_variant	0.54	pyrazinamide
sigE	1364763	c.351T>C	synonymous_variant	0.6	pyrazinamide
sigE	1364767	c.355A>C	synonymous_variant	0.62	pyrazinamide
sigE	1364784	c.372C>G	synonymous_variant	0.66	pyrazinamide
sigE	1364802	c.390C>A	synonymous_variant	0.7	pyrazinamide
sigE	1364811	c.399A>G	synonymous_variant	0.71	pyrazinamide
sigE	1364820	c.408A>G	synonymous_variant	0.7	pyrazinamide
sigE	1364835	c.423C>G	synonymous_variant	0.73	pyrazinamide
sigE	1364839	c.427T>C	synonymous_variant	0.73	pyrazinamide
sigE	1364862	c.450C>G	synonymous_variant	0.76	pyrazinamide
sigE	1364865	c.453G>C	synonymous_variant	0.76	pyrazinamide
sigE	1364866	c.454_456delGCTinsTG	frameshift_variant&missense_variant	0.76	pyrazinamide	Uncertain significance
sigE	1364887	c.475_477delTTAinsCG	frameshift_variant&missense_variant	0.7	pyrazinamide	Uncertain significance
sigE	1364904	p.Asp164Glu	missense_variant	0.69	pyrazinamide
sigE	1364919	c.507T>C	synonymous_variant	0.54	pyrazinamide
sigE	1364928	c.516C>T	synonymous_variant	0.52	pyrazinamide
sigE	1364934	c.522G>A	synonymous_variant	0.52	pyrazinamide
sigE	1364935	p.Gln175Glu	missense_variant	0.52	pyrazinamide
sigE	1364949	c.537C>T	synonymous_variant	0.48	pyrazinamide
sigE	1364950	c.538_540delGCAinsTG	frameshift_variant&stop_gained	0.48	pyrazinamide	Uncertain significance
sigE	1364958	c.546G>C	synonymous_variant	0.5	pyrazinamide
sigE	1364961	c.549A>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
sigE	1364964	c.552T>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
sigE	1364967	c.555C>T	synonymous_variant	0.53	pyrazinamide
sigE	1364976	c.564T>C	synonymous_variant	0.59	pyrazinamide	Not assoc w R - Interim
sigE	1364979	c.567C>G	synonymous_variant	0.59	pyrazinamide
sigE	1364980	c.568T>C	synonymous_variant	0.59	pyrazinamide
sigE	1364984	p.Ala191Asp	missense_variant	0.59	pyrazinamide
sigE	1365003	c.591T>C	synonymous_variant	0.56	pyrazinamide
sigE	1365006	c.594T>C	synonymous_variant	0.5	pyrazinamide
sigE	1365015	c.603G>C	synonymous_variant	0.53	pyrazinamide
sigE	1365024	c.612T>C	synonymous_variant	0.47	pyrazinamide
rrs	1471923	n.78T>C	non_coding_transcript_exon_variant	0.41	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.47	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471969	n.124T>C	non_coding_transcript_exon_variant	0.47	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	0.47	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472028	n.183A>T	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472030	n.185G>A	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472031	n.186G>A	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472034	n.189T>C	non_coding_transcript_exon_variant	0.56	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472044	n.199G>C	non_coding_transcript_exon_variant	0.6	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	0.6	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	0.65	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472969	n.1124A>G	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472970	n.1125C>G	non_coding_transcript_exon_variant	0.67	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472977	n.1132G>C	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	0.64	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.54	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTT	non_coding_transcript_exon_variant	0.52	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.57	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.54	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.45	capreomycin
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.45	linezolid
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.49	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.49	linezolid
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.54	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.54	linezolid	Uncertain significance
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1473839	n.182G>T	non_coding_transcript_exon_variant	0.54	capreomycin
rrl	1473839	n.182G>T	non_coding_transcript_exon_variant	0.54	linezolid
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1473899	n.242A>C	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1473899	n.242A>C	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1473937	n.280C>T	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1473937	n.280C>T	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1473944	n.287G>A	non_coding_transcript_exon_variant	0.53	capreomycin
rrl	1473944	n.287G>A	non_coding_transcript_exon_variant	0.53	linezolid
rrl	1473945	n.288T>C	non_coding_transcript_exon_variant	0.54	capreomycin
rrl	1473945	n.288T>C	non_coding_transcript_exon_variant	0.54	linezolid
rrl	1473981	n.324delGinsTT	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1473981	n.324delGinsTT	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.58	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.58	linezolid	Not assoc w R
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474051	n.394T>C	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1474051	n.394T>C	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1474054	n.397T>C	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1474054	n.397T>C	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1474056	n.399T>C	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1474056	n.399T>C	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474104	n.447G>A	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474104	n.447G>A	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1474112	n.455T>A	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1474112	n.455T>A	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474291	n.634_649delTTTCCTCTCCGGAGGAinsC	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1474291	n.634_649delTTTCCTCTCCGGAGGAinsC	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1474356	n.699T>C	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1474356	n.699T>C	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1474376	n.719T>C	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474376	n.719T>C	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474409	n.756_766delACCCACACGCG	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1474409	n.756_766delACCCACACGCG	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1474427	n.770A>C	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474427	n.770A>C	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474429	n.772G>C	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474429	n.772G>C	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474431	n.774_775delGCinsTTTGGG	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474431	n.774_775delGCinsTTTGGG	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474435	n.780_783delGAAT	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474435	n.780_783delGAAT	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	0.63	capreomycin
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	0.53	capreomycin
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	0.53	linezolid
rrl	1474959	n.1302C>T	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1474959	n.1302C>T	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1474962	n.1306delG	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1474962	n.1306delG	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474991	n.1334T>C	non_coding_transcript_exon_variant	0.53	capreomycin
rrl	1474991	n.1334T>C	non_coding_transcript_exon_variant	0.53	linezolid
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	0.54	capreomycin
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	0.54	linezolid
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.74	capreomycin	Uncertain significance
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1475271	n.1614A>C	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1475271	n.1614A>C	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1475273	n.1616T>A	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1475273	n.1616T>A	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1475313	n.1656G>A	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1475313	n.1656G>A	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1475333	n.1676T>C	non_coding_transcript_exon_variant	0.69	capreomycin
rrl	1475333	n.1676T>C	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1475369	n.1712G>C	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1475369	n.1712G>C	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.77	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.74	linezolid	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1475638	n.1981C>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1475638	n.1981C>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.56	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476025	n.2368G>T	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1476025	n.2368G>T	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.47	capreomycin	Uncertain significance
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.45	capreomycin
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.45	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.45	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.45	linezolid
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.48	capreomycin
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.48	linezolid	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.72	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.41	capreomycin
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.39	capreomycin
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.39	linezolid
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.39	capreomycin
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.39	linezolid
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.36	capreomycin	Uncertain significance
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.36	linezolid
rrl	1476723	n.3066T>A	non_coding_transcript_exon_variant	0.29	capreomycin
rrl	1476723	n.3066T>A	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1476725	n.3068C>T	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1476725	n.3068C>T	non_coding_transcript_exon_variant	0.29	linezolid	Uncertain significance
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.29	capreomycin
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.28	capreomycin
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.28	linezolid
inhA	1674368	p.Ala56Glu	missense_variant	0.4	ethionamide
inhA	1674368	p.Ala56Glu	missense_variant	0.4	isoniazid
inhA	1674379	c.178C>T	synonymous_variant	0.43	ethionamide
inhA	1674379	c.178C>T	synonymous_variant	0.43	isoniazid
inhA	1674382	p.Leu61Ile	missense_variant	0.41	ethionamide
inhA	1674382	p.Leu61Ile	missense_variant	0.41	isoniazid
inhA	1674387	c.186A>G	synonymous_variant	0.4	ethionamide
inhA	1674387	c.186A>G	synonymous_variant	0.4	isoniazid
inhA	1674399	c.198A>G	synonymous_variant	0.39	ethionamide
inhA	1674399	c.198A>G	synonymous_variant	0.39	isoniazid
inhA	1674415	p.Ala72Asn	missense_variant	0.41	ethionamide
inhA	1674415	p.Ala72Asn	missense_variant	0.41	isoniazid
inhA	1674419	p.Ser73Thr	missense_variant	0.4	ethionamide
inhA	1674419	p.Ser73Thr	missense_variant	0.4	isoniazid
inhA	1674421	c.220T>C	synonymous_variant	0.4	ethionamide
inhA	1674421	c.220T>C	synonymous_variant	0.4	isoniazid
inhA	1674427	p.Gly76Gln	missense_variant	0.36	ethionamide
inhA	1674427	p.Gly76Gln	missense_variant	0.36	isoniazid
inhA	1674440	p.Glu80Ala	missense_variant	0.38	ethionamide	Uncertain significance
inhA	1674440	p.Glu80Ala	missense_variant	0.38	isoniazid	Uncertain significance
inhA	1674443	p.Ala81Glu	missense_variant	0.38	ethionamide
inhA	1674443	p.Ala81Glu	missense_variant	0.38	isoniazid
inhA	1674450	c.249G>C	synonymous_variant	0.4	ethionamide
inhA	1674450	c.249G>C	synonymous_variant	0.4	isoniazid
inhA	1674452	p.Ala84Glu	missense_variant	0.4	ethionamide
inhA	1674452	p.Ala84Glu	missense_variant	0.4	isoniazid
inhA	1674480	c.279T>C	synonymous_variant	0.47	ethionamide
inhA	1674480	c.279T>C	synonymous_variant	0.47	isoniazid
inhA	1674486	c.285T>C	synonymous_variant	0.49	ethionamide
inhA	1674486	c.285T>C	synonymous_variant	0.49	isoniazid
inhA	1674489	c.288G>C	synonymous_variant	0.47	ethionamide
inhA	1674489	c.288G>C	synonymous_variant	0.47	isoniazid
inhA	1674507	c.306G>C	synonymous_variant	0.5	ethionamide
inhA	1674507	c.306G>C	synonymous_variant	0.5	isoniazid
inhA	1674537	c.336C>G	synonymous_variant	0.57	ethionamide
inhA	1674537	c.336C>G	synonymous_variant	0.57	isoniazid
inhA	1674542	p.Ala114Glu	missense_variant	0.57	ethionamide
inhA	1674542	p.Ala114Glu	missense_variant	0.57	isoniazid
inhA	1674549	c.348G>C	synonymous_variant	0.6	ethionamide
inhA	1674549	c.348G>C	synonymous_variant	0.6	isoniazid
inhA	1674555	c.354G>A	synonymous_variant	0.59	ethionamide	Not assoc w R - Interim
inhA	1674555	c.354G>A	synonymous_variant	0.59	isoniazid	Not assoc w R - Interim
inhA	1674561	c.360C>T	synonymous_variant	0.6	ethionamide
inhA	1674561	c.360C>T	synonymous_variant	0.6	isoniazid
inhA	1674582	c.381T>C	synonymous_variant	0.62	ethionamide
inhA	1674582	c.381T>C	synonymous_variant	0.62	isoniazid
inhA	1674585	c.384T>C	synonymous_variant	0.6	ethionamide
inhA	1674585	c.384T>C	synonymous_variant	0.6	isoniazid
inhA	1674589	p.Met130Leu	missense_variant	0.6	ethionamide
inhA	1674589	p.Met130Leu	missense_variant	0.6	isoniazid
inhA	1674624	c.423A>C	synonymous_variant	0.74	ethionamide
inhA	1674624	c.423A>C	synonymous_variant	0.74	isoniazid
inhA	1674627	c.426T>G	synonymous_variant	0.74	ethionamide
inhA	1674627	c.426T>G	synonymous_variant	0.74	isoniazid
inhA	1674630	c.429C>G	synonymous_variant	0.75	ethionamide
inhA	1674630	c.429C>G	synonymous_variant	0.75	isoniazid
inhA	1674636	c.435C>G	synonymous_variant	0.76	ethionamide
inhA	1674636	c.435C>G	synonymous_variant	0.76	isoniazid
inhA	1674654	c.453G>C	synonymous_variant	0.79	ethionamide
inhA	1674654	c.453G>C	synonymous_variant	0.79	isoniazid
inhA	1674693	c.492C>G	synonymous_variant	0.81	ethionamide
inhA	1674693	c.492C>G	synonymous_variant	0.81	isoniazid
inhA	1674703	c.502T>C	synonymous_variant	0.79	ethionamide
inhA	1674703	c.502T>C	synonymous_variant	0.79	isoniazid
inhA	1674718	c.517A>C	synonymous_variant	0.76	ethionamide
inhA	1674718	c.517A>C	synonymous_variant	0.76	isoniazid
inhA	1674741	c.540C>G	synonymous_variant	0.73	ethionamide
inhA	1674741	c.540C>G	synonymous_variant	0.73	isoniazid
inhA	1674742	p.Lys181Pro	missense_variant	0.71	ethionamide
inhA	1674742	p.Lys181Pro	missense_variant	0.71	isoniazid
inhA	1674745	p.Tyr182His	missense_variant	0.73	ethionamide	Uncertain significance
inhA	1674745	p.Tyr182His	missense_variant	0.73	isoniazid	Uncertain significance
inhA	1674750	c.549T>C	synonymous_variant	0.73	ethionamide
inhA	1674750	c.549T>C	synonymous_variant	0.73	isoniazid
inhA	1674756	c.555T>C	synonymous_variant	0.74	ethionamide	Not assoc w R - Interim
inhA	1674756	c.555T>C	synonymous_variant	0.74	isoniazid	Not assoc w R - Interim
inhA	1674771	c.570C>G	synonymous_variant	0.75	ethionamide
inhA	1674771	c.570C>G	synonymous_variant	0.75	isoniazid
inhA	1674774	c.573A>G	synonymous_variant	0.71	ethionamide
inhA	1674774	c.573A>G	synonymous_variant	0.71	isoniazid
inhA	1674876	c.675C>G	synonymous_variant	0.62	ethionamide
inhA	1674876	c.675C>G	synonymous_variant	0.62	isoniazid
inhA	1674879	c.678T>C	synonymous_variant	0.62	ethionamide
inhA	1674879	c.678T>C	synonymous_variant	0.62	isoniazid
inhA	1674903	c.702T>C	synonymous_variant	0.53	ethionamide
inhA	1674903	c.702T>C	synonymous_variant	0.53	isoniazid
inhA	1674904	c.703_705delGCGinsCC	frameshift_variant&missense_variant	0.53	ethionamide
inhA	1674904	c.703_705delGCGinsCC	frameshift_variant&missense_variant	0.53	isoniazid
inhA	1674909	c.708G>C	synonymous_variant	0.53	ethionamide
inhA	1674909	c.708G>C	synonymous_variant	0.53	isoniazid
inhA	1674915	c.714C>G	synonymous_variant	0.47	ethionamide
inhA	1674915	c.714C>G	synonymous_variant	0.47	isoniazid
inhA	1674942	c.741T>C	synonymous_variant	0.42	ethionamide
inhA	1674942	c.741T>C	synonymous_variant	0.42	isoniazid
inhA	1674957	c.756G>C	synonymous_variant	0.47	ethionamide
inhA	1674957	c.756G>C	synonymous_variant	0.47	isoniazid
inhA	1674963	c.762G>C	synonymous_variant	0.47	ethionamide
inhA	1674963	c.762G>C	synonymous_variant	0.47	isoniazid
inhA	1674966	c.765T>C	synonymous_variant	0.39	ethionamide
inhA	1674966	c.765T>C	synonymous_variant	0.39	isoniazid
inhA	1674967	p.Asp256Thr	missense_variant	0.39	ethionamide
inhA	1674967	p.Asp256Thr	missense_variant	0.39	isoniazid
rpsA	1833554	p.Thr5Ala	missense_variant	0.6	pyrazinamide	Uncertain significance
rpsA	1833568	c.27G>C	synonymous_variant	0.59	pyrazinamide	Not assoc w R - Interim
rpsA	1833589	c.48A>T	synonymous_variant	0.62	pyrazinamide
rpsA	1833595	c.54T>C	synonymous_variant	0.61	pyrazinamide
rpsA	1833619	c.78A>C	synonymous_variant	0.69	pyrazinamide
rpsA	1833661	c.120A>G	synonymous_variant	0.65	pyrazinamide
rpsA	1833667	c.126C>G	synonymous_variant	0.65	pyrazinamide
rpsA	1833724	c.183C>G	synonymous_variant	0.68	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.69	pyrazinamide
rpsA	1833742	c.201A>G	synonymous_variant	0.71	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.73	pyrazinamide
rpsA	1833787	c.246C>G	synonymous_variant	0.66	pyrazinamide
rpsA	1833790	c.249T>A	synonymous_variant	0.66	pyrazinamide
rpsA	1833799	c.258C>G	synonymous_variant	0.63	pyrazinamide
rpsA	1833811	c.270G>C	synonymous_variant	0.63	pyrazinamide
rpsA	1833838	c.297G>C	synonymous_variant	0.63	pyrazinamide
rpsA	1833841	c.300C>G	synonymous_variant	0.65	pyrazinamide
rpsA	1833847	c.306C>G	synonymous_variant	0.64	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	0.61	pyrazinamide
rpsA	1833862	c.321G>T	synonymous_variant	0.62	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.63	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.62	pyrazinamide
rpsA	1833940	c.399C>G	synonymous_variant	0.56	pyrazinamide
rpsA	1833970	c.429G>C	synonymous_variant	0.55	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.54	pyrazinamide
rpsA	1834000	c.459G>C	synonymous_variant	0.55	pyrazinamide
rpsA	1834015	c.474G>C	synonymous_variant	0.6	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	0.59	pyrazinamide
rpsA	1834097	c.556_557delTCinsAG	synonymous_variant	0.72	pyrazinamide
rpsA	1834102	c.561T>C	synonymous_variant	0.73	pyrazinamide
rpsA	1834150	c.609G>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834153	c.612T>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834154	c.613_615delAACinsCG	frameshift_variant&missense_variant	0.71	pyrazinamide	Uncertain significance
rpsA	1834157	c.616T>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834162	c.621A>G	synonymous_variant	0.71	pyrazinamide	Not assoc w R - Interim
rpsA	1834165	c.624A>G	synonymous_variant	0.71	pyrazinamide
rpsA	1834169	p.Thr210Ala	missense_variant	0.7	pyrazinamide	Uncertain significance
rpsA	1834177	c.636A>C	synonymous_variant	0.71	pyrazinamide	Not assoc w R - Interim
rpsA	1834186	c.645C>G	synonymous_variant	0.71	pyrazinamide
rpsA	1834189	c.648G>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834201	c.660C>T	synonymous_variant	0.71	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.7	pyrazinamide
rpsA	1834225	c.684C>G	synonymous_variant	0.69	pyrazinamide
rpsA	1834240	c.699T>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.7	pyrazinamide
rpsA	1834261	c.720A>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834264	c.723G>C	synonymous_variant	0.72	pyrazinamide
rpsA	1834297	c.756C>G	synonymous_variant	0.76	pyrazinamide
rpsA	1834303	c.762T>G	synonymous_variant	0.74	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	0.74	pyrazinamide
rpsA	1834348	c.807T>C	synonymous_variant	0.78	pyrazinamide	Not assoc w R - Interim
rpsA	1834366	c.825A>G	synonymous_variant	0.78	pyrazinamide	Not assoc w R - Interim
rpsA	1834375	c.834G>A	synonymous_variant	0.78	pyrazinamide
rpsA	1834396	c.855G>C	synonymous_variant	0.76	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.76	pyrazinamide
rpsA	1834417	c.876G>C	synonymous_variant	0.77	pyrazinamide
rpsA	1834423	c.882G>C	synonymous_variant	0.77	pyrazinamide
rpsA	1834435	c.894G>C	synonymous_variant	0.76	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.76	pyrazinamide
rpsA	1834465	c.924T>C	synonymous_variant	0.72	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.73	pyrazinamide
rpsA	1834474	c.933C>G	synonymous_variant	0.75	pyrazinamide
rpsA	1834489	c.948T>C	synonymous_variant	0.74	pyrazinamide
rpsA	1834498	c.957C>T	synonymous_variant	0.72	pyrazinamide
rpsA	1834528	c.987T>C	synonymous_variant	0.67	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	0.64	pyrazinamide
rpsA	1834555	c.1014T>C	synonymous_variant	0.67	pyrazinamide
rpsA	1834558	c.1017C>G	synonymous_variant	0.67	pyrazinamide
rpsA	1834594	c.1053C>T	synonymous_variant	0.62	pyrazinamide
rpsA	1834606	c.1065C>G	synonymous_variant	0.61	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	0.62	pyrazinamide
rpsA	1834622	c.1081_1083delTCGinsAGC	synonymous_variant	0.62	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	0.61	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	0.61	pyrazinamide
rpsA	1834666	c.1125G>C	synonymous_variant	0.65	pyrazinamide
rpsA	1834669	c.1128G>C	synonymous_variant	0.63	pyrazinamide
rpsA	1834688	c.1147_1149delAGTinsTCC	synonymous_variant	0.62	pyrazinamide
rpsA	1834726	c.1185C>A	synonymous_variant	0.68	pyrazinamide
rpsA	1834732	c.1191T>C	synonymous_variant	0.67	pyrazinamide
rpsA	1834733	p.Ala398Pro	missense_variant	0.67	pyrazinamide
rpsA	1834753	c.1212T>C	synonymous_variant	0.6	pyrazinamide
rpsA	1834765	c.1224A>G	synonymous_variant	0.56	pyrazinamide
rpsA	1834780	c.1239A>G	synonymous_variant	0.5	pyrazinamide
rpsA	1834786	c.1245A>G	synonymous_variant	0.5	pyrazinamide
rpsA	1834789	c.1248T>C	synonymous_variant	0.5	pyrazinamide
rpsA	1834792	c.1251G>C	synonymous_variant	0.47	pyrazinamide
tsnR	1853361	c.-245T>C	upstream_gene_variant	0.69	linezolid
tsnR	1853370	c.-236_-234delGCAinsTG	upstream_gene_variant	0.67	linezolid
tsnR	1853384	c.-222G>C	upstream_gene_variant	0.67	linezolid
tsnR	1853387	c.-219T>G	upstream_gene_variant	0.67	linezolid
tsnR	1853394	c.-212_-211delCTinsGC	upstream_gene_variant	0.67	linezolid
tsnR	1853420	c.-186T>G	upstream_gene_variant	0.63	linezolid
tsnR	1853429	c.-177G>C	upstream_gene_variant	0.61	linezolid
tsnR	1853432	c.-174G>C	upstream_gene_variant	0.61	linezolid
tsnR	1853447	c.-159C>G	upstream_gene_variant	0.58	linezolid
tsnR	1853459	c.-147G>C	upstream_gene_variant	0.5	linezolid
tsnR	1853462	c.-144A>G	upstream_gene_variant	0.55	linezolid
tsnR	1853477	c.-129T>C	upstream_gene_variant	0.47	linezolid
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2064963	c.-235G>C	upstream_gene_variant	0.41	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064972	c.-244T>C	upstream_gene_variant	0.39	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064978	c.-250G>C	upstream_gene_variant	0.39	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064979	c.-253_-251delGGCinsCT	upstream_gene_variant	0.37	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064984	c.-256A>G	upstream_gene_variant	0.37	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064993	c.-265T>C	upstream_gene_variant	0.45	streptomycin
					kanamycin
					capreomycin
					amikacin
ndh	2101812	p.Ile411Val	missense_variant	0.33	ethionamide
					delamanid
					isoniazid
ndh	2101825	c.1218G>C	synonymous_variant	0.31	ethionamide
					delamanid
					isoniazid
ndh	2101830	p.Ile405Val	missense_variant	0.3	ethionamide
					delamanid
					isoniazid
ndh	2101834	c.1209C>T	synonymous_variant	0.3	ethionamide
					delamanid	Not assoc w R - Interim
					isoniazid
ndh	2101838	p.Ala402Val	missense_variant	0.31	ethionamide	Uncertain significance
					delamanid
					isoniazid	Uncertain significance
ndh	2101872	p.Ile391Phe	missense_variant	0.31	ethionamide
					delamanid
					isoniazid
ndh	2101873	c.1168_1170delTTTinsCG	frameshift_variant&missense_variant	0.31	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2101885	c.1158G>A	synonymous_variant	0.32	ethionamide
					delamanid
					isoniazid
ndh	2101888	c.1153_1155delGTTinsCG	frameshift_variant&missense_variant	0.32	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2101894	c.1149T>C	synonymous_variant	0.33	ethionamide
					delamanid
					isoniazid
ndh	2101906	c.1137G>C	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2101915	c.1128T>C	synonymous_variant	0.36	ethionamide	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
ndh	2101918	c.1123_1125delAGGinsCC	frameshift_variant&missense_variant	0.36	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2101924	c.1119T>G	synonymous_variant	0.39	ethionamide
					delamanid
					isoniazid
ndh	2101930	c.1113C>A	synonymous_variant	0.4	ethionamide
					delamanid
					isoniazid
ndh	2101939	c.1104A>C	synonymous_variant	0.39	ethionamide
					delamanid
					isoniazid
ndh	2101960	c.1083A>G	synonymous_variant	0.37	ethionamide
					delamanid
					isoniazid
ndh	2101966	c.1077T>G	synonymous_variant	0.37	ethionamide
					delamanid
					isoniazid
ndh	2101972	c.1071G>C	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2101978	c.1063_1065delAACinsGT	frameshift_variant&missense_variant	0.35	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2101988	p.Ala352Gly	missense_variant	0.37	ethionamide
					delamanid
					isoniazid
ndh	2101990	c.1053G>T	synonymous_variant	0.31	ethionamide
					delamanid
					isoniazid
ndh	2102009	p.Ser345Asn	missense_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102020	c.1023A>G	synonymous_variant	0.32	ethionamide
					delamanid
					isoniazid
ndh	2102023	c.1020G>C	synonymous_variant	0.33	ethionamide
					delamanid
					isoniazid	Not assoc w R - Interim
ndh	2102026	c.1017G>C	synonymous_variant	0.33	ethionamide
					delamanid
					isoniazid
ndh	2102050	c.993T>C	synonymous_variant	0.38	ethionamide
					delamanid
					isoniazid
ndh	2102053	c.990G>C	synonymous_variant	0.38	ethionamide
					delamanid
					isoniazid
ndh	2102059	c.984T>C	synonymous_variant	0.4	ethionamide	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
ndh	2102065	c.978G>C	synonymous_variant	0.33	ethionamide
					delamanid
					isoniazid
ndh	2102068	c.975T>C	synonymous_variant	0.33	ethionamide
					delamanid
					isoniazid
ndh	2102076	p.Met323Leu	missense_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102077	c.966T>C	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102083	c.958_960delGTGinsAC	frameshift_variant&missense_variant	0.35	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2102092	c.951G>C	synonymous_variant	0.39	ethionamide
					delamanid
					isoniazid
ndh	2102098	c.945G>C	synonymous_variant	0.39	ethionamide
					delamanid
					isoniazid
ndh	2102103	p.Tyr314His	missense_variant	0.39	ethionamide
					delamanid
					isoniazid
ndh	2102104	c.939G>C	synonymous_variant	0.38	ethionamide
					delamanid
					isoniazid
ndh	2102110	c.933T>C	synonymous_variant	0.38	ethionamide
					delamanid
					isoniazid
ndh	2102131	c.910_912delCAAinsAG	frameshift_variant&synonymous_variant	0.32	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2102140	c.903C>G	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102149	c.894C>T	synonymous_variant	0.32	ethionamide	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
ndh	2102158	c.885T>C	synonymous_variant	0.32	ethionamide
					delamanid
					isoniazid
ndh	2102162	p.Arg294Thr	missense_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102164	c.879A>G	synonymous_variant	0.36	ethionamide
					delamanid
					isoniazid
ndh	2102167	c.876A>G	synonymous_variant	0.36	ethionamide
					delamanid
					isoniazid
ndh	2102176	c.867T>G	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102182	c.859_861delAGGinsCC	frameshift_variant&missense_variant	0.36	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2102190	c.853T>C	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102192	p.Arg284Pro	missense_variant	0.33	ethionamide
					delamanid
					isoniazid
ndh	2102194	c.849T>C	synonymous_variant	0.33	ethionamide
					delamanid
					isoniazid
ndh	2102203	c.840T>A	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102206	c.837G>C	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2102212	c.831G>C	synonymous_variant	0.38	ethionamide
					delamanid
					isoniazid
ndh	2102218	c.825C>G	synonymous_variant	0.38	ethionamide
					delamanid
					isoniazid
ndh	2102233	c.810G>A	synonymous_variant	0.39	ethionamide	Not assoc w R - Interim
					delamanid
					isoniazid	Not assoc w R - Interim
PPE35	2169775	p.Ala280Thr	missense_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
kasA	2517947	c.-168C>T	upstream_gene_variant	0.45	isoniazid
kasA	2517974	c.-141T>C	upstream_gene_variant	0.44	isoniazid
kasA	2517989	c.-126T>C	upstream_gene_variant	0.47	isoniazid
kasA	2517992	c.-123C>G	upstream_gene_variant	0.46	isoniazid
kasA	2518019	c.-96A>G	upstream_gene_variant	0.36	isoniazid
kasA	2518025	c.-90G>C	upstream_gene_variant	0.38	isoniazid
kasA	2518031	c.-84G>T	upstream_gene_variant	0.33	isoniazid
kasA	2518034	c.-81T>C	upstream_gene_variant	0.3	isoniazid
kasA	2518035	c.-80C>G	upstream_gene_variant	0.3	isoniazid
kasA	2518049	c.-66G>C	upstream_gene_variant	0.29	isoniazid
kasA	2518053	c.-62_-60delATTinsCG	upstream_gene_variant	0.28	isoniazid
kasA	2518059	c.-56_-54delTCGinsAC	upstream_gene_variant	0.28	isoniazid
kasA	2518073	c.-42T>G	upstream_gene_variant	0.29	isoniazid
kasA	2518076	c.-39C>T	upstream_gene_variant	1.0	isoniazid
kasA	2518079	c.-36T>C	upstream_gene_variant	0.3	isoniazid
kasA	2518088	c.-27T>C	upstream_gene_variant	0.27	isoniazid
kasA	2518089	c.-26C>A	upstream_gene_variant	0.27	isoniazid
kasA	2518094	c.-21G>A	upstream_gene_variant	0.27	isoniazid
kasA	2518103	c.-12G>A	upstream_gene_variant	0.26	isoniazid
kasA	2518110	c.-5T>A	upstream_gene_variant	0.27	isoniazid
kasA	2518121	p.Gln3Lys	missense_variant	0.26	isoniazid
kasA	2518132	c.18C>T	synonymous_variant	0.24	isoniazid
kasA	2518519	c.405G>C	synonymous_variant	0.43	isoniazid
kasA	2518528	c.414C>G	synonymous_variant	0.5	isoniazid
kasA	2518540	c.426T>G	synonymous_variant	0.5	isoniazid
kasA	2518561	c.447T>C	synonymous_variant	0.49	isoniazid
kasA	2518567	c.453G>C	synonymous_variant	0.5	isoniazid
kasA	2518570	c.456G>C	synonymous_variant	0.5	isoniazid
kasA	2518574	c.460_462delATCinsGG	frameshift_variant&missense_variant	0.53	isoniazid
kasA	2518588	c.474T>C	synonymous_variant	0.57	isoniazid
kasA	2518591	c.477G>C	synonymous_variant	0.55	isoniazid
kasA	2518609	p.Met165Ile	missense_variant	0.52	isoniazid
kasA	2518621	c.507G>A	synonymous_variant	0.6	isoniazid
kasA	2518642	c.528A>G	synonymous_variant	0.7	isoniazid
kasA	2518663	c.549T>C	synonymous_variant	0.75	isoniazid
kasA	2518672	c.558G>C	synonymous_variant	0.79	isoniazid
kasA	2518687	c.573C>T	synonymous_variant	0.84	isoniazid
kasA	2518696	c.582C>G	synonymous_variant	0.82	isoniazid
kasA	2518702	c.588C>T	synonymous_variant	0.87	isoniazid
kasA	2518711	c.597A>G	synonymous_variant	0.84	isoniazid
kasA	2518714	c.600A>C	synonymous_variant	0.84	isoniazid
kasA	2518732	c.618C>G	synonymous_variant	0.88	isoniazid
kasA	2518741	c.627G>C	synonymous_variant	0.86	isoniazid
kasA	2518747	c.633C>G	synonymous_variant	0.83	isoniazid
kasA	2518768	c.654C>G	synonymous_variant	0.76	isoniazid
kasA	2518783	c.669T>C	synonymous_variant	0.71	isoniazid
kasA	2518792	c.678C>G	synonymous_variant	0.66	isoniazid
kasA	2518795	c.681C>G	synonymous_variant	0.64	isoniazid
kasA	2518816	c.702C>A	synonymous_variant	0.67	isoniazid
kasA	2518822	c.708C>G	synonymous_variant	0.67	isoniazid
kasA	2518825	c.711T>C	synonymous_variant	0.68	isoniazid
kasA	2518855	c.741C>G	synonymous_variant	0.64	isoniazid
kasA	2518864	c.750G>C	synonymous_variant	0.64	isoniazid
kasA	2518879	c.765A>G	synonymous_variant	0.57	isoniazid
kasA	2518885	c.771T>C	synonymous_variant	0.52	isoniazid
kasA	2518888	c.774C>T	synonymous_variant	0.52	isoniazid
kasA	2518898	c.784T>C	synonymous_variant	0.5	isoniazid
kasA	2518906	c.792A>G	synonymous_variant	0.48	isoniazid
kasA	2518910	p.Leu266Met	missense_variant	0.48	isoniazid
Rv2477c	2782621	c.1422T>C	synonymous_variant	0.26	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2782633	c.1410G>C	synonymous_variant	0.26	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782639	c.1404A>G	synonymous_variant	0.25	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782645	c.1398C>G	synonymous_variant	0.29	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782651	c.1392T>C	synonymous_variant	0.29	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782669	c.1374A>G	synonymous_variant	0.28	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782675	c.1368G>C	synonymous_variant	0.23	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782695	c.1348A>C	synonymous_variant	0.23	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782774	c.1269G>C	synonymous_variant	0.28	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782777	c.1266A>G	synonymous_variant	0.27	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782790	p.Thr418Asn	missense_variant	0.27	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782792	c.1251A>G	synonymous_variant	0.28	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782795	c.1248T>C	synonymous_variant	0.28	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782803	p.Gln414Glu	missense_variant	0.32	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782807	c.1236T>C	synonymous_variant	0.34	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782816	c.1227T>A	synonymous_variant	0.34	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782828	c.1215T>C	synonymous_variant	0.35	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2782894	c.1149C>G	synonymous_variant	0.45	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782897	c.1146G>A	synonymous_variant	0.45	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782913	p.Ser377Thr	missense_variant	0.49	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782924	c.1119G>C	synonymous_variant	0.41	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782928	p.Thr372Gln	missense_variant	0.41	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782930	c.1113G>A	synonymous_variant	0.45	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782933	c.1110C>G	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782948	c.1095A>G	synonymous_variant	0.56	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782957	c.1086A>G	synonymous_variant	0.57	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2782969	c.1074A>C	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782981	c.1062G>C	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782984	c.1059T>C	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783002	c.1041T>C	synonymous_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783008	c.1035C>G	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783013	c.1030T>C	synonymous_variant	0.72	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783015	p.Ser343Thr	missense_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783020	c.1023G>C	synonymous_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783040	p.Ala335Thr	missense_variant	0.7	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					kanamycin	Uncertain significance
					rifampicin	Uncertain significance
					amikacin	Uncertain significance
Rv2477c	2783059	c.984T>C	synonymous_variant	0.74	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783062	c.981C>G	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783068	p.Asp325Glu	missense_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783077	c.966T>C	synonymous_variant	0.74	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783092	c.951A>G	synonymous_variant	0.74	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783095	c.948C>G	synonymous_variant	0.74	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2477c	2783110	c.933C>A	synonymous_variant	0.76	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783116	c.927T>C	synonymous_variant	0.76	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783140	c.903C>G	synonymous_variant	0.75	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783158	c.885A>G	synonymous_variant	0.77	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783185	c.858G>C	synonymous_variant	0.71	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783194	c.849A>G	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783203	c.840C>T	synonymous_variant	0.68	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783221	c.822G>T	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783224	c.819C>G	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783235	c.808T>C	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783243	p.Thr267Ser	missense_variant	0.61	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783247	c.796T>C	synonymous_variant	0.61	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783254	c.789A>G	synonymous_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783263	c.780G>C	synonymous_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783278	c.765A>G	synonymous_variant	0.49	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783287	c.756C>G	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783290	c.753G>C	synonymous_variant	0.48	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783293	p.Glu250Asp	missense_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783299	c.744A>G	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783302	c.741A>G	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783320	c.723C>T	synonymous_variant	0.47	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783332	c.711T>C	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783350	c.693T>C	synonymous_variant	0.56	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783353	c.690T>C	synonymous_variant	0.55	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783359	c.684G>A	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783362	c.681G>C	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783365	c.678C>T	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783373	p.Glu224Gln	missense_variant	0.55	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783395	c.648T>C	synonymous_variant	0.6	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783416	c.625_627delATCinsGG	frameshift_variant&missense_variant	0.57	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					kanamycin	Uncertain significance
					rifampicin	Uncertain significance
					amikacin	Uncertain significance
Rv2477c	2783422	c.621T>C	synonymous_variant	0.57	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783425	c.616_618delCCCinsGG	frameshift_variant&missense_variant	0.56	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					kanamycin	Uncertain significance
					rifampicin	Uncertain significance
					amikacin	Uncertain significance
Rv2477c	2783432	p.Ser204Ala	missense_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783434	c.609C>G	synonymous_variant	0.61	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783440	c.603T>C	synonymous_variant	0.6	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783461	c.582T>C	synonymous_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783467	c.576G>C	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783473	c.570A>G	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783485	c.558G>C	synonymous_variant	0.7	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783494	c.549C>G	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783502	c.541T>C	synonymous_variant	0.71	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783512	c.531A>G	synonymous_variant	0.74	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783520	c.523T>C	synonymous_variant	0.77	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783527	c.516A>G	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783548	c.495T>C	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783551	c.492G>A	synonymous_variant	0.8	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783563	c.480A>G	synonymous_variant	0.78	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783569	c.474C>G	synonymous_variant	0.79	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783572	c.471A>G	synonymous_variant	0.78	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783578	p.Glu155Asp	missense_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783586	p.Ala153Pro	missense_variant	0.79	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783593	c.450T>C	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783605	c.438T>C	synonymous_variant	0.85	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783611	c.432C>G	synonymous_variant	0.85	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783628	p.Ala139Ser	missense_variant	0.78	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783629	c.414C>T	synonymous_variant	0.78	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783641	c.402G>C	synonymous_variant	0.79	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783656	c.387G>C	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783659	c.384A>G	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783665	c.378A>G	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783674	c.369T>C	synonymous_variant	0.71	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783683	c.360A>G	synonymous_variant	0.71	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783691	c.352C>T	synonymous_variant	0.69	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783700	p.Thr115Ser	missense_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783719	c.324A>G	synonymous_variant	0.57	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783751	p.Ile98Val	missense_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783755	c.288C>T	synonymous_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783758	p.Asp95Glu	missense_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783761	c.282G>C	synonymous_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783766	p.Met93Leu	missense_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783773	c.270A>G	synonymous_variant	0.57	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783776	c.267G>C	synonymous_variant	0.56	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783779	c.264T>C	synonymous_variant	0.56	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783794	c.249G>A	synonymous_variant	0.55	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783797	p.Asp82Glu	missense_variant	0.54	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783815	c.228A>G	synonymous_variant	0.54	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783833	c.210G>C	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783843	p.Gly67Asp	missense_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783860	p.Asp61Glu	missense_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783863	c.180C>T	synonymous_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783883	c.160T>C	synonymous_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783884	c.159T>C	synonymous_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783887	c.156C>G	synonymous_variant	0.55	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783920	c.123G>C	synonymous_variant	0.54	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783953	c.90G>A	synonymous_variant	0.44	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783962	c.81T>C	synonymous_variant	0.42	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783971	c.72G>C	synonymous_variant	0.35	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2784455	c.-413A>C	upstream_gene_variant	0.36	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2784456	c.-414A>C	upstream_gene_variant	0.36	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2784472	c.-430C>A	upstream_gene_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2784477	c.-435T>C	upstream_gene_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2784492	c.-450C>G	upstream_gene_variant	0.39	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2784501	c.-459T>C	upstream_gene_variant	0.41	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2681	2997054	p.Ser106Gly	missense_variant	0.33	capreomycin	Uncertain significance
Rv2681	2997058	p.Thr107Ser	missense_variant	0.33	capreomycin
Rv2681	2997060	p.Asn108Asp	missense_variant	0.33	capreomycin
Rv2681	2997071	c.333C>T	synonymous_variant	0.29	capreomycin
Rv2681	2997083	c.345C>G	synonymous_variant	0.31	capreomycin
Rv2681	2997092	c.354T>C	synonymous_variant	0.3	capreomycin
Rv2681	2997104	c.366C>G	synonymous_variant	0.27	capreomycin
Rv2681	2997107	c.369C>G	synonymous_variant	0.26	capreomycin
Rv2681	2997113	c.375C>G	synonymous_variant	0.26	capreomycin
Rv2681	2997122	c.384A>G	synonymous_variant	0.23	capreomycin	Not assoc w R - Interim
Rv2681	2997134	c.396A>G	synonymous_variant	0.25	capreomycin
Rv2681	2997137	c.399C>T	synonymous_variant	0.25	capreomycin
Rv2752c	3064860	c.1332G>C	synonymous_variant	0.32	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065418	c.774A>G	synonymous_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065457	c.735A>T	synonymous_variant	0.52	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065463	c.729T>C	synonymous_variant	0.52	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065481	c.711T>C	synonymous_variant	0.46	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
Rv2752c	3065484	c.708G>C	synonymous_variant	0.46	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065487	c.705T>G	synonymous_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065490	c.702A>C	synonymous_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065493	c.699G>C	synonymous_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065496	c.696G>C	synonymous_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065499	c.693A>C	synonymous_variant	0.43	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065502	p.Asp230Glu	missense_variant	0.43	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065508	c.684T>C	synonymous_variant	0.43	ethambutol	Not assoc w R - Interim
					moxifloxacin
					levofloxacin
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
Rv2752c	3065511	c.681G>C	synonymous_variant	0.43	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065517	c.675C>G	synonymous_variant	0.43	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065529	c.663G>C	synonymous_variant	0.42	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065532	c.660A>G	synonymous_variant	0.41	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065538	c.654G>C	synonymous_variant	0.42	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065553	c.639A>C	synonymous_variant	0.4	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065556	c.636G>C	synonymous_variant	0.38	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065562	c.630T>C	synonymous_variant	0.39	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065568	c.622_624delATCinsCG	frameshift_variant&missense_variant	0.41	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
Rv2752c	3065580	c.612G>C	synonymous_variant	0.44	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065586	c.606C>T	synonymous_variant	0.39	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
Rv2752c	3065595	p.Leu199Phe	missense_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065601	c.591C>T	synonymous_variant	0.29	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065604	c.588G>C	synonymous_variant	0.29	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065607	c.585C>G	synonymous_variant	0.29	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065612	p.Thr194Ala	missense_variant	0.29	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065616	c.576C>T	synonymous_variant	0.28	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
Rv2752c	3065634	c.558G>C	synonymous_variant	0.26	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065947	p.Gly82Ala	missense_variant	0.25	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065955	c.235_237delTTGinsCC	frameshift_variant&missense_variant	0.28	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
Rv2752c	3065979	c.213T>C	synonymous_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065993	p.Val67Ile	missense_variant	0.35	ethambutol	Uncertain significance
					moxifloxacin
					levofloxacin
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
Rv2752c	3065994	c.198T>C	synonymous_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065997	c.195C>G	synonymous_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066002	p.Met64Leu	missense_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066024	c.168T>C	synonymous_variant	0.31	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066040	p.Gly51Thr	missense_variant	0.31	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066042	c.150T>C	synonymous_variant	0.3	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066050	p.Leu48Met	missense_variant	0.28	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066054	c.138T>G	synonymous_variant	0.28	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066066	c.126T>C	synonymous_variant	0.25	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066075	c.117A>G	synonymous_variant	0.28	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066087	c.105A>G	synonymous_variant	0.28	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
Rv2752c	3066549	c.-358T>C	upstream_gene_variant	0.33	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066567	c.-376C>G	upstream_gene_variant	0.39	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066573	c.-382G>C	upstream_gene_variant	0.36	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066579	c.-388A>G	upstream_gene_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066583	c.-392C>G	upstream_gene_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066589	c.-399_-398delAGinsGC	upstream_gene_variant	0.34	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066603	c.-412A>G	upstream_gene_variant	0.39	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066618	c.-427A>C	upstream_gene_variant	0.43	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066630	c.-439G>C	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066633	c.-442T>C	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066644	c.-453T>C	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066654	c.-463G>C	upstream_gene_variant	0.44	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066658	c.-468_-467delGAinsAG	upstream_gene_variant	0.46	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066660	c.-471_-469delCCCinsTG	upstream_gene_variant	0.46	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066669	c.-478G>C	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066676	c.-485C>T	upstream_gene_variant	0.44	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066681	c.-490G>C	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066684	c.-493G>A	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066687	c.-496G>C	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066690	c.-499C>T	upstream_gene_variant	0.46	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066696	c.-505T>C	upstream_gene_variant	0.45	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066707	c.-516A>G	upstream_gene_variant	0.5	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066714	c.-523G>A	upstream_gene_variant	0.5	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066744	c.-553C>G	upstream_gene_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066747	c.-558_-556delCAAinsATC	upstream_gene_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066756	c.-565G>C	upstream_gene_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066765	c.-574G>C	upstream_gene_variant	0.55	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066774	c.-583T>C	upstream_gene_variant	0.58	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066807	c.-616T>C	upstream_gene_variant	0.52	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066819	c.-628T>C	upstream_gene_variant	0.4	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066822	c.-631T>C	upstream_gene_variant	0.4	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066839	c.-648A>G	upstream_gene_variant	0.44	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066855	c.-664T>C	upstream_gene_variant	0.39	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
thyX	3067355	c.591A>C	synonymous_variant	0.32	para-aminosalicylic_acid
thyX	3067367	c.579G>C	synonymous_variant	0.38	para-aminosalicylic_acid
thyX	3067376	c.570G>C	synonymous_variant	0.39	para-aminosalicylic_acid
thyX	3067391	c.555G>C	synonymous_variant	0.38	para-aminosalicylic_acid
thyX	3067394	c.552G>C	synonymous_variant	0.38	para-aminosalicylic_acid
thyX	3067412	c.534C>G	synonymous_variant	0.52	para-aminosalicylic_acid
thyX	3067439	c.507A>G	synonymous_variant	0.59	para-aminosalicylic_acid
thyX	3067451	c.495G>A	synonymous_variant	0.63	para-aminosalicylic_acid
thyX	3067457	c.489C>G	synonymous_variant	0.63	para-aminosalicylic_acid
thyX	3067463	c.481_483delATCinsGA	frameshift_variant&missense_variant	0.59	para-aminosalicylic_acid
thyX	3067466	c.480G>C	synonymous_variant	0.59	para-aminosalicylic_acid
thyX	3067470	p.Asn159Ser	missense_variant	0.59	para-aminosalicylic_acid
thyX	3067493	c.453A>G	synonymous_variant	0.66	para-aminosalicylic_acid
thyX	3067500	p.Lys149Arg	missense_variant	0.66	para-aminosalicylic_acid
thyX	3067515	p.Ser144Thr	missense_variant	0.69	para-aminosalicylic_acid
thyX	3067526	c.420C>G	synonymous_variant	0.68	para-aminosalicylic_acid
thyX	3067530	p.Ala139Ser	missense_variant	0.68	para-aminosalicylic_acid
thyX	3067545	p.Glu134Ala	missense_variant	0.64	para-aminosalicylic_acid
thyX	3067549	p.Thr133Ala	missense_variant	0.62	para-aminosalicylic_acid
thyX	3067556	p.His130Gln	missense_variant	0.6	para-aminosalicylic_acid
thyX	3067559	p.Arg129Gln	missense_variant	0.58	para-aminosalicylic_acid
thyX	3067565	p.Asp127Glu	missense_variant	0.62	para-aminosalicylic_acid
thyX	3067570	p.Ala126Pro	missense_variant	0.62	para-aminosalicylic_acid
thyX	3067571	c.375C>T	synonymous_variant	0.62	para-aminosalicylic_acid
thyX	3067577	p.Glu123Asp	missense_variant	0.62	para-aminosalicylic_acid
thyX	3067582	p.Met122Leu	missense_variant	0.64	para-aminosalicylic_acid
thyX	3067586	c.360C>G	synonymous_variant	0.61	para-aminosalicylic_acid
thyX	3067601	c.345G>C	synonymous_variant	0.64	para-aminosalicylic_acid
thyX	3067604	c.342G>C	synonymous_variant	0.63	para-aminosalicylic_acid
thyX	3067610	p.Lys112Asn	missense_variant	0.59	para-aminosalicylic_acid
thyX	3067613	c.333G>A	synonymous_variant	0.57	para-aminosalicylic_acid
thyX	3067619	c.327A>G	synonymous_variant	0.58	para-aminosalicylic_acid
thyX	3067640	c.306G>C	synonymous_variant	0.59	para-aminosalicylic_acid
thyX	3067643	c.303C>T	synonymous_variant	0.59	para-aminosalicylic_acid
thyX	3067652	c.294T>C	synonymous_variant	0.6	para-aminosalicylic_acid
thyX	3067661	c.285C>G	synonymous_variant	0.51	para-aminosalicylic_acid
thyX	3067682	c.264G>C	synonymous_variant	0.51	para-aminosalicylic_acid
thyX	3067685	c.261A>G	synonymous_variant	0.51	para-aminosalicylic_acid
thyX	3067688	c.258G>C	synonymous_variant	0.51	para-aminosalicylic_acid
thyX	3067694	c.252G>C	synonymous_variant	0.5	para-aminosalicylic_acid
thyX	3067718	c.228C>G	synonymous_variant	0.51	para-aminosalicylic_acid
thyX	3067721	c.225T>C	synonymous_variant	0.53	para-aminosalicylic_acid
thyX	3067724	c.222G>A	synonymous_variant	0.51	para-aminosalicylic_acid
thyX	3067727	c.219A>C	synonymous_variant	0.51	para-aminosalicylic_acid
thyX	3067739	c.207T>C	synonymous_variant	0.47	para-aminosalicylic_acid
thyX	3067742	c.204A>C	synonymous_variant	0.46	para-aminosalicylic_acid
thyX	3067761	p.Arg62Lys	missense_variant	0.39	para-aminosalicylic_acid
thyX	3067765	p.Leu61Ile	missense_variant	0.39	para-aminosalicylic_acid
thyX	3067781	c.165C>G	synonymous_variant	0.4	para-aminosalicylic_acid
thyX	3067787	c.159G>A	synonymous_variant	0.44	para-aminosalicylic_acid
thyX	3067793	c.153T>C	synonymous_variant	0.42	para-aminosalicylic_acid
thyX	3067799	c.147G>A	synonymous_variant	0.44	para-aminosalicylic_acid
thyX	3067802	c.144C>G	synonymous_variant	0.45	para-aminosalicylic_acid
thyX	3067814	c.132T>C	synonymous_variant	0.44	para-aminosalicylic_acid
thyX	3067826	c.120C>G	synonymous_variant	0.38	para-aminosalicylic_acid
thyX	3067850	c.96A>C	synonymous_variant	0.32	para-aminosalicylic_acid
thyA	3073892	c.580T>C	synonymous_variant	0.41	para-aminosalicylic_acid
thyA	3073893	c.579C>G	synonymous_variant	0.41	para-aminosalicylic_acid
thyA	3073925	c.547T>C	synonymous_variant	0.42	para-aminosalicylic_acid
thyA	3073926	c.546G>C	synonymous_variant	0.44	para-aminosalicylic_acid
thyA	3073929	c.543T>C	synonymous_variant	0.42	para-aminosalicylic_acid
thyA	3073953	c.519T>C	synonymous_variant	0.52	para-aminosalicylic_acid
thyA	3073977	c.495A>G	synonymous_variant	0.44	para-aminosalicylic_acid
thyA	3073989	c.483T>C	synonymous_variant	0.46	para-aminosalicylic_acid
thyA	3074001	c.471C>G	synonymous_variant	0.43	para-aminosalicylic_acid
thyA	3074004	c.468T>C	synonymous_variant	0.43	para-aminosalicylic_acid
thyA	3074010	c.462C>A	synonymous_variant	0.43	para-aminosalicylic_acid
thyA	3074031	c.441T>C	synonymous_variant	0.45	para-aminosalicylic_acid
thyA	3074037	c.435C>G	synonymous_variant	0.48	para-aminosalicylic_acid
thyA	3074056	p.Glu139Pro	missense_variant	0.48	para-aminosalicylic_acid
thyA	3074061	c.411A>G	synonymous_variant	0.48	para-aminosalicylic_acid
thyA	3074076	c.396C>G	synonymous_variant	0.52	para-aminosalicylic_acid
thyA	3074082	c.390G>C	synonymous_variant	0.5	para-aminosalicylic_acid
thyA	3074199	c.273G>A	synonymous_variant	0.47	para-aminosalicylic_acid
thyA	3074205	p.Glu89Asp	missense_variant	0.47	para-aminosalicylic_acid
thyA	3074217	c.255T>C	synonymous_variant	0.46	para-aminosalicylic_acid
thyA	3074235	c.237C>T	synonymous_variant	0.43	para-aminosalicylic_acid
thyA	3074244	c.228A>C	synonymous_variant	0.41	para-aminosalicylic_acid
thyA	3074251	p.Glu74Arg	missense_variant	0.42	para-aminosalicylic_acid
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
Rv3083	3449566	p.Gly355Arg	missense_variant	1.0	ethionamide
lpqB	3624371	c.540T>G	synonymous_variant	0.38	bedaquiline
lpqB	3624371	c.540T>G	synonymous_variant	0.38	rifampicin
lpqB	3624389	c.522C>G	synonymous_variant	0.41	bedaquiline
lpqB	3624389	c.522C>G	synonymous_variant	0.41	rifampicin
lpqB	3624401	c.510C>T	synonymous_variant	0.41	bedaquiline
lpqB	3624401	c.510C>T	synonymous_variant	0.41	rifampicin
lpqB	3624407	c.504C>G	synonymous_variant	0.41	bedaquiline
lpqB	3624407	c.504C>G	synonymous_variant	0.41	rifampicin
lpqB	3624422	c.489G>C	synonymous_variant	0.36	bedaquiline
lpqB	3624422	c.489G>C	synonymous_variant	0.36	rifampicin
lpqB	3624425	p.Glu162Ala	missense_variant	0.37	bedaquiline
lpqB	3624425	p.Glu162Ala	missense_variant	0.37	rifampicin
lpqB	3624428	c.483A>G	synonymous_variant	0.38	bedaquiline
lpqB	3624428	c.483A>G	synonymous_variant	0.38	rifampicin
lpqB	3624452	c.459T>C	synonymous_variant	0.44	bedaquiline
lpqB	3624452	c.459T>C	synonymous_variant	0.44	rifampicin
lpqB	3624464	c.447A>G	synonymous_variant	0.49	bedaquiline
lpqB	3624464	c.447A>G	synonymous_variant	0.49	rifampicin
lpqB	3624470	c.441T>C	synonymous_variant	0.49	bedaquiline
lpqB	3624470	c.441T>C	synonymous_variant	0.49	rifampicin
lpqB	3624476	c.435C>G	synonymous_variant	0.47	bedaquiline
lpqB	3624476	c.435C>G	synonymous_variant	0.47	rifampicin
lpqB	3624482	c.429T>C	synonymous_variant	0.46	bedaquiline
lpqB	3624482	c.429T>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
lpqB	3624485	p.Asp142Gly	missense_variant	0.45	bedaquiline	Uncertain significance
lpqB	3624485	p.Asp142Gly	missense_variant	0.45	rifampicin	Not assoc w R
lpqB	3624491	c.420G>C	synonymous_variant	0.44	bedaquiline
lpqB	3624491	c.420G>C	synonymous_variant	0.44	rifampicin
lpqB	3624512	c.399C>G	synonymous_variant	0.45	bedaquiline
lpqB	3624512	c.399C>G	synonymous_variant	0.45	rifampicin
lpqB	3624518	c.393T>C	synonymous_variant	0.45	bedaquiline
lpqB	3624518	c.393T>C	synonymous_variant	0.45	rifampicin
lpqB	3624521	c.390G>C	synonymous_variant	0.46	bedaquiline
lpqB	3624521	c.390G>C	synonymous_variant	0.46	rifampicin
lpqB	3624527	p.Gln128Val	missense_variant	0.43	bedaquiline
lpqB	3624527	p.Gln128Val	missense_variant	0.43	rifampicin
lpqB	3624530	c.381T>G	synonymous_variant	0.44	bedaquiline
lpqB	3624530	c.381T>G	synonymous_variant	0.44	rifampicin
lpqB	3624545	c.366T>C	synonymous_variant	0.5	bedaquiline
lpqB	3624545	c.366T>C	synonymous_variant	0.5	rifampicin
lpqB	3624556	p.Val119Met	missense_variant	0.5	bedaquiline
lpqB	3624556	p.Val119Met	missense_variant	0.5	rifampicin	Uncertain significance
lpqB	3624557	c.354T>C	synonymous_variant	0.5	bedaquiline
lpqB	3624557	c.354T>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
lpqB	3624563	c.348C>G	synonymous_variant	0.5	bedaquiline
lpqB	3624563	c.348C>G	synonymous_variant	0.5	rifampicin
lpqB	3624569	c.342C>T	synonymous_variant	0.5	bedaquiline
lpqB	3624569	c.342C>T	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
lpqB	3624572	c.339C>G	synonymous_variant	0.51	bedaquiline
lpqB	3624572	c.339C>G	synonymous_variant	0.51	rifampicin
lpqB	3624581	c.330A>C	synonymous_variant	0.46	bedaquiline
lpqB	3624581	c.330A>C	synonymous_variant	0.46	rifampicin
lpqB	3624594	p.Val106Ala	missense_variant	0.4	bedaquiline
lpqB	3624594	p.Val106Ala	missense_variant	0.4	rifampicin
lpqB	3624602	p.Lys103Arg	missense_variant	0.36	bedaquiline
lpqB	3624602	p.Lys103Arg	missense_variant	0.36	rifampicin
lpqB	3624605	c.306G>A	synonymous_variant	0.36	bedaquiline
lpqB	3624605	c.306G>A	synonymous_variant	0.36	rifampicin
lpqB	3624611	p.Ser100Ala	missense_variant	0.35	bedaquiline
lpqB	3624611	p.Ser100Ala	missense_variant	0.35	rifampicin
lpqB	3624614	c.297A>T	synonymous_variant	0.35	bedaquiline
lpqB	3624614	c.297A>T	synonymous_variant	0.35	rifampicin
lpqB	3624623	c.288C>G	synonymous_variant	0.37	bedaquiline
lpqB	3624623	c.288C>G	synonymous_variant	0.37	rifampicin
lpqB	3624632	c.279G>C	synonymous_variant	0.42	bedaquiline
lpqB	3624632	c.279G>C	synonymous_variant	0.42	rifampicin
lpqB	3624641	c.270C>T	synonymous_variant	0.43	bedaquiline
lpqB	3624641	c.270C>T	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
lpqB	3624646	c.265T>C	synonymous_variant	0.43	bedaquiline
lpqB	3624646	c.265T>C	synonymous_variant	0.43	rifampicin
lpqB	3624649	c.262T>C	synonymous_variant	0.42	bedaquiline
lpqB	3624649	c.262T>C	synonymous_variant	0.42	rifampicin
lpqB	3624680	c.231T>G	synonymous_variant	0.42	bedaquiline
lpqB	3624680	c.231T>G	synonymous_variant	0.42	rifampicin
lpqB	3624686	c.223_225delGAAinsCG	frameshift_variant&missense_variant	0.43	bedaquiline
lpqB	3624686	c.223_225delGAAinsCG	frameshift_variant&missense_variant	0.43	rifampicin	Uncertain significance
lpqB	3624701	c.210T>C	synonymous_variant	0.33	bedaquiline
lpqB	3624701	c.210T>C	synonymous_variant	0.33	rifampicin
lpqB	3624713	c.198C>T	synonymous_variant	0.23	bedaquiline
lpqB	3624713	c.198C>T	synonymous_variant	0.23	rifampicin
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
mtrB	3625321	c.1293A>G	synonymous_variant	0.47	bedaquiline	Not assoc w R - Interim
mtrB	3625321	c.1293A>G	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
lpqB	3625327	c.-417A>G	upstream_gene_variant	0.47	bedaquiline
lpqB	3625327	c.-417A>G	upstream_gene_variant	0.47	rifampicin
lpqB	3625345	c.-435T>C	upstream_gene_variant	0.45	bedaquiline
lpqB	3625345	c.-435T>C	upstream_gene_variant	0.45	rifampicin
mtrB	3625351	c.1263T>C	synonymous_variant	0.45	bedaquiline
mtrB	3625351	c.1263T>C	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
lpqB	3625357	c.-447T>C	upstream_gene_variant	0.43	bedaquiline
lpqB	3625357	c.-447T>C	upstream_gene_variant	0.43	rifampicin
lpqB	3625365	c.-455C>T	upstream_gene_variant	0.4	bedaquiline
lpqB	3625365	c.-455C>T	upstream_gene_variant	0.4	rifampicin
lpqB	3625372	c.-462A>G	upstream_gene_variant	0.4	bedaquiline
lpqB	3625372	c.-462A>G	upstream_gene_variant	0.4	rifampicin
lpqB	3625375	c.-465A>G	upstream_gene_variant	0.37	bedaquiline
lpqB	3625375	c.-465A>G	upstream_gene_variant	0.37	rifampicin
lpqB	3625381	c.-471T>C	upstream_gene_variant	0.39	bedaquiline
lpqB	3625381	c.-471T>C	upstream_gene_variant	0.39	rifampicin
mtrB	3625384	c.1228_1230delGCGinsAC	frameshift_variant&missense_variant	0.39	bedaquiline	Uncertain significance
mtrB	3625384	c.1228_1230delGCGinsAC	frameshift_variant&missense_variant	0.39	rifampicin	Uncertain significance
lpqB	3625387	c.-477T>C	upstream_gene_variant	0.39	bedaquiline
lpqB	3625387	c.-477T>C	upstream_gene_variant	0.39	rifampicin
lpqB	3625396	c.-486G>C	upstream_gene_variant	0.39	bedaquiline
lpqB	3625396	c.-486G>C	upstream_gene_variant	0.39	rifampicin
lpqB	3625402	c.-492G>C	upstream_gene_variant	0.41	bedaquiline
lpqB	3625402	c.-492G>C	upstream_gene_variant	0.41	rifampicin
mtrB	3625407	p.Gln403Glu	missense_variant	0.39	bedaquiline
mtrB	3625407	p.Gln403Glu	missense_variant	0.39	rifampicin
lpqB	3625414	c.-504C>G	upstream_gene_variant	0.33	bedaquiline
lpqB	3625414	c.-504C>G	upstream_gene_variant	0.33	rifampicin
mtrB	3625420	p.Asp398Glu	missense_variant	0.33	bedaquiline
mtrB	3625420	p.Asp398Glu	missense_variant	0.33	rifampicin
mtrB	3625427	p.Leu396Gln	missense_variant	0.32	bedaquiline
mtrB	3625427	p.Leu396Gln	missense_variant	0.32	rifampicin
mtrB	3625429	c.1183_1185delTTGinsCA	frameshift_variant&missense_variant	0.32	bedaquiline	Uncertain significance
mtrB	3625429	c.1183_1185delTTGinsCA	frameshift_variant&missense_variant	0.32	rifampicin	Uncertain significance
lpqB	3625432	c.-522G>A	upstream_gene_variant	0.32	bedaquiline
lpqB	3625432	c.-522G>A	upstream_gene_variant	0.32	rifampicin
lpqB	3625438	c.-528T>C	upstream_gene_variant	0.32	bedaquiline
lpqB	3625438	c.-528T>C	upstream_gene_variant	0.32	rifampicin
mtrB	3625444	p.Glu390Asp	missense_variant	0.29	bedaquiline
mtrB	3625444	p.Glu390Asp	missense_variant	0.29	rifampicin
lpqB	3625456	c.-546C>T	upstream_gene_variant	0.29	bedaquiline
lpqB	3625456	c.-546C>T	upstream_gene_variant	0.29	rifampicin
lpqB	3625459	c.-549C>G	upstream_gene_variant	0.29	bedaquiline
lpqB	3625459	c.-549C>G	upstream_gene_variant	0.29	rifampicin
lpqB	3625525	c.-615G>C	upstream_gene_variant	0.29	bedaquiline
lpqB	3625525	c.-615G>C	upstream_gene_variant	0.29	rifampicin
lpqB	3625543	c.-633G>C	upstream_gene_variant	0.39	bedaquiline
lpqB	3625543	c.-633G>C	upstream_gene_variant	0.39	rifampicin
mtrB	3625569	c.1045T>C	synonymous_variant	0.43	bedaquiline
mtrB	3625569	c.1045T>C	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
mtrB	3625572	p.Thr348Ser	missense_variant	0.41	bedaquiline
mtrB	3625572	p.Thr348Ser	missense_variant	0.41	rifampicin
lpqB	3625579	c.-669A>G	upstream_gene_variant	0.42	bedaquiline
lpqB	3625579	c.-669A>G	upstream_gene_variant	0.42	rifampicin
mtrB	3625592	p.Ser341Asn	missense_variant	0.39	bedaquiline
mtrB	3625592	p.Ser341Asn	missense_variant	0.39	rifampicin
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.39	bedaquiline
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.39	rifampicin
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.41	bedaquiline
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.41	rifampicin
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.39	bedaquiline
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.39	rifampicin
mtrB	3625616	p.Arg333Ala	missense_variant	0.39	bedaquiline
mtrB	3625616	p.Arg333Ala	missense_variant	0.39	rifampicin
lpqB	3625624	c.-714C>G	upstream_gene_variant	0.41	bedaquiline
lpqB	3625624	c.-714C>G	upstream_gene_variant	0.41	rifampicin
lpqB	3625627	c.-717C>T	upstream_gene_variant	0.44	bedaquiline
lpqB	3625627	c.-717C>T	upstream_gene_variant	0.44	rifampicin
lpqB	3625648	c.-738T>C	upstream_gene_variant	0.44	bedaquiline
lpqB	3625648	c.-738T>C	upstream_gene_variant	0.44	rifampicin
mtrB	3625656	c.958T>C	synonymous_variant	0.49	bedaquiline	Not assoc w R - Interim
mtrB	3625656	c.958T>C	synonymous_variant	0.49	rifampicin	Not assoc w R - Interim
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.49	bedaquiline
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.49	rifampicin
lpqB	3625669	c.-759G>C	upstream_gene_variant	0.51	bedaquiline
lpqB	3625669	c.-759G>C	upstream_gene_variant	0.51	rifampicin
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.57	bedaquiline
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.57	rifampicin
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.59	bedaquiline
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.59	rifampicin
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.6	bedaquiline
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.6	rifampicin
mtrB	3625705	c.909C>G	synonymous_variant	0.62	bedaquiline
mtrB	3625705	c.909C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.61	bedaquiline
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.61	rifampicin
mtrB	3625720	c.894G>C	synonymous_variant	0.62	bedaquiline
mtrB	3625720	c.894G>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
mtrB	3625729	c.885A>G	synonymous_variant	0.58	bedaquiline
mtrB	3625729	c.885A>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
mtrB	3625735	c.879C>A	synonymous_variant	0.58	bedaquiline
mtrB	3625735	c.879C>A	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
mtrB	3625750	c.864G>A	synonymous_variant	0.57	bedaquiline
mtrB	3625750	c.864G>A	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
mtrB	3625755	p.Ala287Thr	missense_variant	0.55	bedaquiline
mtrB	3625755	p.Ala287Thr	missense_variant	0.55	rifampicin	Uncertain significance
mtrB	3625762	c.852A>G	synonymous_variant	0.55	bedaquiline
mtrB	3625762	c.852A>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
mtrB	3625765	c.849C>G	synonymous_variant	0.55	bedaquiline
mtrB	3625765	c.849C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
mtrB	3625797	p.Val273Met	missense_variant	0.5	bedaquiline	Uncertain significance
mtrB	3625797	p.Val273Met	missense_variant	0.5	rifampicin	Uncertain significance
mtrB	3625806	c.808A>C	synonymous_variant	0.48	bedaquiline
mtrB	3625806	c.808A>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
mtrB	3625837	c.777C>G	synonymous_variant	0.4	bedaquiline
mtrB	3625837	c.777C>G	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
lpqB	3625840	c.-930A>G	upstream_gene_variant	0.42	bedaquiline
lpqB	3625840	c.-930A>G	upstream_gene_variant	0.42	rifampicin
mtrB	3625852	c.762A>G	synonymous_variant	0.39	bedaquiline
mtrB	3625852	c.762A>G	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
lpqB	3625888	c.-978G>T	upstream_gene_variant	0.36	bedaquiline
lpqB	3625888	c.-978G>T	upstream_gene_variant	0.36	rifampicin
lpqB	3625909	c.-999T>G	upstream_gene_variant	0.25	bedaquiline
lpqB	3625909	c.-999T>G	upstream_gene_variant	0.25	rifampicin
mtrB	3626704	c.-91C>T	upstream_gene_variant	0.33	bedaquiline
mtrB	3626704	c.-91C>T	upstream_gene_variant	0.33	rifampicin
mtrB	3626711	c.-98T>C	upstream_gene_variant	0.34	bedaquiline
mtrB	3626711	c.-98T>C	upstream_gene_variant	0.34	rifampicin
mtrA	3626723	c.627C>T	synonymous_variant	0.39	bedaquiline
mtrA	3626723	c.627C>T	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
mtrB	3626726	c.-113T>C	upstream_gene_variant	0.39	bedaquiline
mtrB	3626726	c.-113T>C	upstream_gene_variant	0.39	rifampicin
mtrB	3626729	c.-116G>A	upstream_gene_variant	0.38	bedaquiline
mtrB	3626729	c.-116G>A	upstream_gene_variant	0.38	rifampicin
mtrB	3626732	c.-119A>G	upstream_gene_variant	0.39	bedaquiline
mtrB	3626732	c.-119A>G	upstream_gene_variant	0.39	rifampicin
mtrA	3626759	c.591T>C	synonymous_variant	0.48	bedaquiline
mtrA	3626759	c.591T>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
mtrA	3626774	c.574_576delAGGinsCC	frameshift_variant&missense_variant	0.5	bedaquiline
mtrA	3626774	c.574_576delAGGinsCC	frameshift_variant&missense_variant	0.5	rifampicin
mtrB	3626780	c.-167T>C	upstream_gene_variant	0.52	bedaquiline
mtrB	3626780	c.-167T>C	upstream_gene_variant	0.52	rifampicin
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.52	bedaquiline
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.52	rifampicin
mtrA	3626786	c.564A>G	synonymous_variant	0.54	bedaquiline
mtrA	3626786	c.564A>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
mtrB	3626795	c.-182C>T	upstream_gene_variant	0.57	bedaquiline
mtrB	3626795	c.-182C>T	upstream_gene_variant	0.57	rifampicin
mtrB	3626798	c.-185T>C	upstream_gene_variant	0.59	bedaquiline
mtrB	3626798	c.-185T>C	upstream_gene_variant	0.59	rifampicin
mtrA	3626804	c.546A>G	synonymous_variant	0.6	bedaquiline
mtrA	3626804	c.546A>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.59	bedaquiline
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.59	rifampicin
mtrA	3626846	c.504G>A	synonymous_variant	0.59	bedaquiline
mtrA	3626846	c.504G>A	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.56	bedaquiline
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.56	rifampicin
mtrB	3626861	c.-248C>G	upstream_gene_variant	0.58	bedaquiline
mtrB	3626861	c.-248C>G	upstream_gene_variant	0.58	rifampicin
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.58	bedaquiline
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.58	rifampicin
mtrB	3626885	c.-272A>C	upstream_gene_variant	0.59	bedaquiline
mtrB	3626885	c.-272A>C	upstream_gene_variant	0.59	rifampicin
mtrB	3626903	c.-290T>C	upstream_gene_variant	0.6	bedaquiline
mtrB	3626903	c.-290T>C	upstream_gene_variant	0.6	rifampicin
mtrA	3626912	c.438T>C	synonymous_variant	0.61	bedaquiline
mtrA	3626912	c.438T>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.6	bedaquiline
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.6	rifampicin
mtrA	3626939	c.411A>G	synonymous_variant	0.62	bedaquiline
mtrA	3626939	c.411A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
mtrB	3626942	c.-329A>G	upstream_gene_variant	0.64	bedaquiline
mtrB	3626942	c.-329A>G	upstream_gene_variant	0.64	rifampicin
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.63	bedaquiline
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.63	rifampicin
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.64	bedaquiline
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.64	rifampicin
mtrB	3627065	c.-452G>C	upstream_gene_variant	0.69	bedaquiline
mtrB	3627065	c.-452G>C	upstream_gene_variant	0.69	rifampicin
mtrA	3627068	c.282T>C	synonymous_variant	0.69	bedaquiline
mtrA	3627068	c.282T>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
mtrB	3627074	c.-461G>C	upstream_gene_variant	0.69	bedaquiline
mtrB	3627074	c.-461G>C	upstream_gene_variant	0.69	rifampicin
mtrA	3627080	c.270T>C	synonymous_variant	0.67	bedaquiline
mtrA	3627080	c.270T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
mtrB	3627083	c.-470G>C	upstream_gene_variant	0.66	bedaquiline
mtrB	3627083	c.-470G>C	upstream_gene_variant	0.66	rifampicin
mtrA	3627098	c.252A>C	synonymous_variant	0.67	bedaquiline
mtrA	3627098	c.252A>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.69	bedaquiline
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.69	rifampicin
mtrA	3627119	c.231T>G	synonymous_variant	0.66	bedaquiline
mtrA	3627119	c.231T>G	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
mtrB	3627122	c.-509T>C	upstream_gene_variant	0.65	bedaquiline
mtrB	3627122	c.-509T>C	upstream_gene_variant	0.65	rifampicin
mtrB	3627128	c.-515T>C	upstream_gene_variant	0.65	bedaquiline
mtrB	3627128	c.-515T>C	upstream_gene_variant	0.65	rifampicin
mtrB	3627139	c.-526T>C	upstream_gene_variant	0.64	bedaquiline
mtrB	3627139	c.-526T>C	upstream_gene_variant	0.64	rifampicin
mtrB	3627167	c.-554T>C	upstream_gene_variant	0.64	bedaquiline
mtrB	3627167	c.-554T>C	upstream_gene_variant	0.64	rifampicin
mtrB	3627170	c.-557C>G	upstream_gene_variant	0.61	bedaquiline
mtrB	3627170	c.-557C>G	upstream_gene_variant	0.61	rifampicin
mtrB	3627181	c.-568T>C	upstream_gene_variant	0.6	bedaquiline
mtrB	3627181	c.-568T>C	upstream_gene_variant	0.6	rifampicin
mtrB	3627182	c.-569T>C	upstream_gene_variant	0.6	bedaquiline
mtrB	3627182	c.-569T>C	upstream_gene_variant	0.6	rifampicin
mtrA	3627188	c.160_162delTTAinsCG	frameshift_variant&missense_variant	0.62	bedaquiline
mtrA	3627188	c.160_162delTTAinsCG	frameshift_variant&missense_variant	0.62	rifampicin
mtrB	3627191	c.-578G>C	upstream_gene_variant	0.6	bedaquiline
mtrB	3627191	c.-578G>C	upstream_gene_variant	0.6	rifampicin
mtrB	3627197	c.-584T>C	upstream_gene_variant	0.58	bedaquiline
mtrB	3627197	c.-584T>C	upstream_gene_variant	0.58	rifampicin
mtrA	3627227	c.123T>C	synonymous_variant	0.56	bedaquiline
mtrA	3627227	c.123T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
mtrB	3627233	c.-620T>C	upstream_gene_variant	0.56	bedaquiline
mtrB	3627233	c.-620T>C	upstream_gene_variant	0.56	rifampicin
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.56	bedaquiline
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.56	rifampicin
mtrA	3627242	c.108C>T	synonymous_variant	0.6	bedaquiline
mtrA	3627242	c.108C>T	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
mtrB	3627254	c.-641C>T	upstream_gene_variant	0.5	bedaquiline
mtrB	3627254	c.-641C>T	upstream_gene_variant	0.5	rifampicin
mtrB	3627263	c.-650C>T	upstream_gene_variant	0.44	bedaquiline
mtrB	3627263	c.-650C>T	upstream_gene_variant	0.44	rifampicin
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.44	bedaquiline
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.44	rifampicin
mtrB	3627272	c.-659G>T	upstream_gene_variant	0.43	bedaquiline
mtrB	3627272	c.-659G>T	upstream_gene_variant	0.43	rifampicin
mtrB	3627296	c.-683T>C	upstream_gene_variant	0.3	bedaquiline
mtrB	3627296	c.-683T>C	upstream_gene_variant	0.3	rifampicin
mtrA	3627299	c.49_51delTTGinsCC	frameshift_variant&missense_variant	0.3	bedaquiline
mtrA	3627299	c.49_51delTTGinsCC	frameshift_variant&missense_variant	0.3	rifampicin
mtrB	3627314	c.-701C>T	upstream_gene_variant	0.3	bedaquiline
mtrB	3627314	c.-701C>T	upstream_gene_variant	0.3	rifampicin
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.3	bedaquiline
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.3	rifampicin
mtrA	3627323	c.25_27delTTGinsCC	frameshift_variant&missense_variant	0.29	bedaquiline
mtrA	3627323	c.25_27delTTGinsCC	frameshift_variant&missense_variant	0.29	rifampicin
mtrA	3627343	p.Thr3Ser	missense_variant	0.32	bedaquiline
mtrA	3627343	p.Thr3Ser	missense_variant	0.32	rifampicin
fbiB	3642602	c.1068A>C	synonymous_variant	0.26	clofazimine
					pretomanid
					delamanid
fbiB	3642605	c.1071A>G	synonymous_variant	0.26	clofazimine
					pretomanid
					delamanid
fbiB	3642614	c.1080C>T	synonymous_variant	0.26	clofazimine
					pretomanid
					delamanid
fbiB	3642656	c.1122G>C	synonymous_variant	0.27	clofazimine
					pretomanid
					delamanid
fbiB	3642668	c.1134A>C	synonymous_variant	0.26	clofazimine
					pretomanid
					delamanid
rpoA	3877482	c.1026C>G	synonymous_variant	0.42	rifampicin
rpoA	3877494	p.Glu338Asp	missense_variant	0.52	rifampicin	Uncertain significance
rpoA	3877503	c.1005G>C	synonymous_variant	0.54	rifampicin
rpoA	3877507	p.Gly334Ala	missense_variant	0.58	rifampicin
rpoA	3877515	c.993G>C	synonymous_variant	0.61	rifampicin
rpoA	3877542	c.966C>T	synonymous_variant	0.65	rifampicin
rpoA	3877553	p.Glu319Gln	missense_variant	0.61	rifampicin
rpoA	3877557	c.951C>G	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoA	3877587	c.921A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3877613	p.Ile299Val	missense_variant	0.57	rifampicin
rpoA	3877638	c.870T>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoA	3877656	c.852T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoA	3877668	c.840A>G	synonymous_variant	0.68	rifampicin
rpoA	3877677	p.Ala277Ser	missense_variant	0.68	rifampicin
rpoA	3877680	c.828G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoA	3877686	c.822A>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoA	3877692	c.816G>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoA	3877704	c.804G>T	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoA	3877743	c.765T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3877764	c.744C>G	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoA	3877770	c.738A>G	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoA	3877776	c.732T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoA	3877782	c.726T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoA	3877818	c.690A>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoA	3877839	c.669G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoA	3877857	c.651G>A	synonymous_variant	0.72	rifampicin
rpoA	3877866	c.642G>C	synonymous_variant	0.74	rifampicin
rpoA	3877872	c.636C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoA	3877875	c.633T>G	synonymous_variant	0.75	rifampicin
rpoA	3877899	p.Ser203Thr	missense_variant	0.69	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoA	3877908	p.Asn200Ser	missense_variant	0.68	rifampicin
rpoA	3877962	c.546G>T	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoA	3877986	c.522G>C	synonymous_variant	0.65	rifampicin
rpoA	3877989	c.519A>G	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoA	3878001	c.507A>G	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoA	3878022	c.486T>C	synonymous_variant	0.6	rifampicin
rpoA	3878025	c.483C>T	synonymous_variant	0.6	rifampicin
rpoA	3878028	c.480G>C	synonymous_variant	0.61	rifampicin
rpoA	3878031	c.477T>C	synonymous_variant	0.62	rifampicin
rpoA	3878040	c.468T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoA	3878046	c.462T>C	synonymous_variant	0.57	rifampicin
rpoA	3878049	c.459G>C	synonymous_variant	0.56	rifampicin
rpoA	3878055	c.453A>G	synonymous_variant	0.52	rifampicin
rpoA	3878061	c.447G>C	synonymous_variant	0.51	rifampicin
rpoA	3878067	c.441C>G	synonymous_variant	0.51	rifampicin
rpoA	3878070	c.438T>C	synonymous_variant	0.5	rifampicin
rpoA	3878082	c.426T>C	synonymous_variant	0.53	rifampicin
rpoA	3878094	c.414C>G	synonymous_variant	0.52	rifampicin
rpoA	3878100	c.408C>G	synonymous_variant	0.49	rifampicin
rpoA	3878103	c.405A>G	synonymous_variant	0.49	rifampicin
rpoA	3878106	c.402G>C	synonymous_variant	0.5	rifampicin
rpoA	3878118	c.390T>C	synonymous_variant	0.52	rifampicin
rpoA	3878141	p.Met123Leu	missense_variant	0.6	rifampicin	Uncertain significance
rpoA	3878142	p.Gly122Glu	missense_variant	0.6	rifampicin
rpoA	3878169	c.339G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoA	3878184	c.324C>T	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3878187	c.321C>G	synonymous_variant	0.62	rifampicin
rpoA	3878193	c.315T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoA	3878199	c.309T>C	synonymous_variant	0.6	rifampicin
rpoA	3878202	c.306G>C	synonymous_variant	0.59	rifampicin
rpoA	3878217	c.291A>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoA	3878220	c.288C>T	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoA	3878271	c.237T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoA	3878284	p.Glu75Ala	missense_variant	0.53	rifampicin
rpoA	3878292	c.216T>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoA	3878298	c.210A>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoA	3878304	c.204G>C	synonymous_variant	0.53	rifampicin
rpoA	3878313	c.195G>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoA	3878322	c.186A>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoA	3878331	c.177A>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoA	3878334	c.174T>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoA	3878337	c.171T>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoA	3878346	c.162T>C	synonymous_variant	0.47	rifampicin
rpoA	3878364	c.144A>G	synonymous_variant	0.46	rifampicin
rpoA	3878367	c.141C>G	synonymous_variant	0.44	rifampicin
rpoA	3878370	c.138T>C	synonymous_variant	0.44	rifampicin
rpoA	3878376	c.132G>C	synonymous_variant	0.44	rifampicin
rpoA	3878385	c.123C>G	synonymous_variant	0.44	rifampicin
rpoA	3878391	c.117T>C	synonymous_variant	0.46	rifampicin
rpoA	3878396	c.112C>T	synonymous_variant	0.49	rifampicin
rpoA	3878436	c.72A>G	synonymous_variant	0.4	rifampicin
rpoA	3878442	c.66G>C	synonymous_variant	0.43	rifampicin
rpoA	3878454	c.54A>C	synonymous_variant	0.46	rifampicin
rpoA	3878472	p.Asp12Glu	missense_variant	0.3	rifampicin
rpoA	3878478	c.30C>G	synonymous_variant	0.33	rifampicin
rpoA	3878716	c.-209C>G	upstream_gene_variant	0.29	rifampicin
rpoA	3878725	c.-218A>G	upstream_gene_variant	0.3	rifampicin
rpoA	3878737	c.-230G>C	upstream_gene_variant	0.34	rifampicin
rpoA	3878742	c.-235G>A	upstream_gene_variant	0.33	rifampicin
rpoA	3878746	c.-239A>G	upstream_gene_variant	0.35	rifampicin	Uncertain significance
rpoA	3878764	c.-257A>G	upstream_gene_variant	0.42	rifampicin
rpoA	3878781	c.-274A>G	upstream_gene_variant	0.44	rifampicin
rpoA	3878782	c.-275G>C	upstream_gene_variant	0.45	rifampicin
rpoA	3878785	c.-278T>G	upstream_gene_variant	0.44	rifampicin
rpoA	3878788	c.-281G>C	upstream_gene_variant	0.44	rifampicin	Uncertain significance
rpoA	3878797	c.-290G>C	upstream_gene_variant	0.45	rifampicin
rpoA	3878806	c.-299C>G	upstream_gene_variant	0.47	rifampicin
rpoA	3878809	c.-302T>C	upstream_gene_variant	0.47	rifampicin
rpoA	3878826	c.-319A>T	upstream_gene_variant	0.5	rifampicin
rpoA	3878833	c.-326C>G	upstream_gene_variant	0.5	rifampicin
rpoA	3878838	c.-331A>C	upstream_gene_variant	0.51	rifampicin
rpoA	3878839	c.-332C>G	upstream_gene_variant	0.51	rifampicin
rpoA	3878842	c.-335G>C	upstream_gene_variant	0.51	rifampicin
rpoA	3878845	c.-338G>T	upstream_gene_variant	0.54	rifampicin
rpoA	3878853	c.-346G>A	upstream_gene_variant	0.58	rifampicin
rpoA	3878875	c.-368C>T	upstream_gene_variant	0.65	rifampicin	Uncertain significance
rpoA	3878878	c.-371T>C	upstream_gene_variant	0.64	rifampicin	Uncertain significance
rpoA	3878884	c.-377C>G	upstream_gene_variant	0.66	rifampicin
rpoA	3878889	c.-382A>G	upstream_gene_variant	0.65	rifampicin
rpoA	3878894	c.-387A>G	upstream_gene_variant	0.66	rifampicin
rpoA	3878908	c.-402_-401delACinsCG	upstream_gene_variant	0.65	rifampicin
rpoA	3878914	c.-407T>C	upstream_gene_variant	0.67	rifampicin	Uncertain significance
rpoA	3878917	c.-410G>C	upstream_gene_variant	0.69	rifampicin
rpoA	3878924	c.-417G>C	upstream_gene_variant	0.75	rifampicin
rpoA	3878938	c.-431T>G	upstream_gene_variant	0.81	rifampicin
rpoA	3878947	c.-440G>C	upstream_gene_variant	0.82	rifampicin	Uncertain significance
rpoA	3878956	c.-449G>C	upstream_gene_variant	0.84	rifampicin
rpoA	3878962	c.-455G>C	upstream_gene_variant	0.83	rifampicin
rpoA	3878968	c.-461T>G	upstream_gene_variant	0.8	rifampicin
rpoA	3878976	c.-469A>G	upstream_gene_variant	0.81	rifampicin	Uncertain significance
rpoA	3878989	c.-482G>C	upstream_gene_variant	0.81	rifampicin
rpoA	3878998	c.-491C>G	upstream_gene_variant	0.81	rifampicin	Uncertain significance
rpoA	3879005	c.-499_-498delAAinsCG	upstream_gene_variant	0.83	rifampicin
rpoA	3879012	c.-505C>T	upstream_gene_variant	0.79	rifampicin	Uncertain significance
rpoA	3879013	c.-506A>G	upstream_gene_variant	0.79	rifampicin
rpoA	3879016	c.-509A>G	upstream_gene_variant	0.79	rifampicin
rpoA	3879037	c.-530G>C	upstream_gene_variant	0.81	rifampicin
rpoA	3879040	c.-533G>C	upstream_gene_variant	0.79	rifampicin
rpoA	3879049	c.-542A>G	upstream_gene_variant	0.79	rifampicin
rpoA	3879079	c.-572A>G	upstream_gene_variant	0.71	rifampicin
rpoA	3879088	c.-581A>C	upstream_gene_variant	0.7	rifampicin
rpoA	3879094	c.-587T>C	upstream_gene_variant	0.71	rifampicin
rpoA	3879121	c.-614T>G	upstream_gene_variant	0.68	rifampicin
rpoA	3879127	c.-620T>C	upstream_gene_variant	0.68	rifampicin
rpoA	3879136	c.-629A>G	upstream_gene_variant	0.77	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	0.79	rifampicin
rpoA	3879160	c.-653A>G	upstream_gene_variant	0.81	rifampicin
rpoA	3879178	c.-671T>C	upstream_gene_variant	0.81	rifampicin
rpoA	3879190	c.-683C>G	upstream_gene_variant	0.78	rifampicin
rpoA	3879222	c.-715T>C	upstream_gene_variant	0.76	rifampicin
rpoA	3879226	c.-719G>C	upstream_gene_variant	0.53	rifampicin
rpoA	3879229	c.-722A>G	upstream_gene_variant	0.53	rifampicin
rpoA	3879232	c.-725A>G	upstream_gene_variant	0.53	rifampicin
ddn	3986648	c.-196C>G	upstream_gene_variant	0.58	delamanid
ddn	3986648	c.-196C>G	upstream_gene_variant	0.58	pretomanid
ddn	3986655	c.-189A>T	upstream_gene_variant	0.6	delamanid
ddn	3986655	c.-189A>T	upstream_gene_variant	0.6	pretomanid
ddn	3986660	c.-184C>T	upstream_gene_variant	0.53	delamanid
ddn	3986660	c.-184C>T	upstream_gene_variant	0.53	pretomanid
ddn	3986665	c.-179G>C	upstream_gene_variant	0.53	delamanid
ddn	3986665	c.-179G>C	upstream_gene_variant	0.53	pretomanid
ddn	3986667	c.-177_-176delCTinsAC	upstream_gene_variant	0.56	delamanid
ddn	3986667	c.-177_-176delCTinsAC	upstream_gene_variant	0.56	pretomanid
ddn	3986681	c.-163C>G	upstream_gene_variant	0.5	delamanid
ddn	3986681	c.-163C>G	upstream_gene_variant	0.5	pretomanid
ddn	3986690	c.-154C>G	upstream_gene_variant	0.44	delamanid
ddn	3986690	c.-154C>G	upstream_gene_variant	0.44	pretomanid
ddn	3986696	c.-148G>T	upstream_gene_variant	0.4	delamanid
ddn	3986696	c.-148G>T	upstream_gene_variant	0.4	pretomanid
clpC1	4038271	p.Pro812Ala	missense_variant	0.58	pyrazinamide
clpC1	4038272	c.2431_2433delGGTinsAC	frameshift_variant&missense_variant	0.58	pyrazinamide
clpC1	4038278	c.2427T>C	synonymous_variant	0.62	pyrazinamide
clpC1	4038293	c.2412G>C	synonymous_variant	0.76	pyrazinamide
clpC1	4038302	c.2403C>G	synonymous_variant	0.65	pyrazinamide
clpC1	4038308	c.2395_2397delGTGinsAC	frameshift_variant&missense_variant	0.65	pyrazinamide
clpC1	4038317	c.2388G>C	synonymous_variant	0.65	pyrazinamide
clpC1	4038347	c.2358G>C	synonymous_variant	0.66	pyrazinamide
clpC1	4038356	c.2349T>C	synonymous_variant	0.65	pyrazinamide
clpC1	4038359	c.2346A>G	synonymous_variant	0.65	pyrazinamide
clpC1	4038368	c.2337T>C	synonymous_variant	0.68	pyrazinamide
clpC1	4038388	c.2317T>C	synonymous_variant	0.72	pyrazinamide
clpC1	4038398	c.2307G>T	synonymous_variant	0.73	pyrazinamide
clpC1	4038403	c.2302T>C	synonymous_variant	0.74	pyrazinamide	Not assoc w R - Interim
clpC1	4038419	c.2286T>C	synonymous_variant	0.7	pyrazinamide
clpC1	4038434	c.2271G>C	synonymous_variant	0.73	pyrazinamide
clpC1	4038444	p.Ala754Lys	missense_variant	0.72	pyrazinamide
clpC1	4038446	c.2259T>C	synonymous_variant	0.73	pyrazinamide
clpC1	4038452	c.2253G>C	synonymous_variant	0.74	pyrazinamide
clpC1	4038461	p.Ala748Asp	missense_variant	0.74	pyrazinamide
clpC1	4038498	p.Ser736Thr	missense_variant	0.77	pyrazinamide
clpC1	4038530	p.Glu725Asp	missense_variant	0.76	pyrazinamide
clpC1	4038536	c.2169C>T	synonymous_variant	0.73	pyrazinamide	Not assoc w R - Interim
clpC1	4038596	c.2109A>G	synonymous_variant	0.78	pyrazinamide
clpC1	4038623	c.2082A>G	synonymous_variant	0.83	pyrazinamide
clpC1	4038640	p.Asp689Asn	missense_variant	0.83	pyrazinamide
clpC1	4038653	c.2052C>T	synonymous_variant	0.8	pyrazinamide
clpC1	4038658	p.Lys683Gln	missense_variant	0.8	pyrazinamide
clpC1	4038661	p.Ser682Thr	missense_variant	0.77	pyrazinamide
clpC1	4038662	c.2043T>C	synonymous_variant	0.77	pyrazinamide
clpC1	4038671	c.2034T>C	synonymous_variant	0.8	pyrazinamide
clpC1	4038683	c.2022T>C	synonymous_variant	0.79	pyrazinamide	Not assoc w R - Interim
clpC1	4038695	c.2010C>G	synonymous_variant	0.79	pyrazinamide
clpC1	4038701	c.2004G>C	synonymous_variant	0.77	pyrazinamide
clpC1	4038704	c.2001T>C	synonymous_variant	0.76	pyrazinamide
clpC1	4038707	c.1998C>G	synonymous_variant	0.75	pyrazinamide
clpC1	4038710	c.1995G>C	synonymous_variant	0.75	pyrazinamide
clpC1	4038713	c.1992T>C	synonymous_variant	0.74	pyrazinamide
clpC1	4038740	c.1965G>C	synonymous_variant	0.69	pyrazinamide
clpC1	4038755	c.1950G>C	synonymous_variant	0.69	pyrazinamide
clpC1	4038773	c.1932T>C	synonymous_variant	0.66	pyrazinamide
clpC1	4038782	c.1923G>C	synonymous_variant	0.65	pyrazinamide
clpC1	4038790	c.1915C>T	synonymous_variant	0.67	pyrazinamide	Not assoc w R - Interim
clpC1	4038812	c.1893T>C	synonymous_variant	0.64	pyrazinamide
clpC1	4038815	c.1890G>T	synonymous_variant	0.64	pyrazinamide
clpC1	4038878	c.1827A>G	synonymous_variant	0.62	pyrazinamide	Not assoc w R - Interim
clpC1	4038908	c.1797C>G	synonymous_variant	0.67	pyrazinamide
clpC1	4038914	c.1791G>C	synonymous_variant	0.69	pyrazinamide
clpC1	4038923	c.1782A>G	synonymous_variant	0.62	pyrazinamide
clpC1	4038932	c.1773G>C	synonymous_variant	0.62	pyrazinamide
clpC1	4038953	c.1752A>G	synonymous_variant	0.62	pyrazinamide
clpC1	4038956	c.1749T>C	synonymous_variant	0.61	pyrazinamide
clpC1	4038965	c.1740T>C	synonymous_variant	0.59	pyrazinamide
clpC1	4038971	c.1734T>C	synonymous_variant	0.58	pyrazinamide
clpC1	4038974	c.1731T>C	synonymous_variant	0.58	pyrazinamide	Not assoc w R - Interim
clpC1	4038989	c.1716T>C	synonymous_variant	0.63	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.63	pyrazinamide	Not assoc w R - Interim
clpC1	4039022	c.1683A>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039073	c.1632C>G	synonymous_variant	0.74	pyrazinamide
clpC1	4039085	c.1620A>G	synonymous_variant	0.75	pyrazinamide
clpC1	4039090	c.1615C>T	synonymous_variant	0.76	pyrazinamide
clpC1	4039097	c.1608G>C	synonymous_variant	0.76	pyrazinamide
clpC1	4039103	c.1602T>C	synonymous_variant	0.79	pyrazinamide
clpC1	4039106	c.1599G>C	synonymous_variant	0.78	pyrazinamide
clpC1	4039112	c.1593C>G	synonymous_variant	0.78	pyrazinamide
clpC1	4039121	c.1584T>C	synonymous_variant	0.77	pyrazinamide
clpC1	4039124	c.1581C>G	synonymous_variant	0.73	pyrazinamide
clpC1	4039127	c.1578G>A	synonymous_variant	0.71	pyrazinamide
clpC1	4039142	c.1563A>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039145	c.1560G>C	synonymous_variant	0.68	pyrazinamide
clpC1	4039169	p.Glu512Asp	missense_variant	0.79	pyrazinamide
clpC1	4039172	c.1533A>G	synonymous_variant	0.83	pyrazinamide
clpC1	4039178	c.1527G>C	synonymous_variant	0.79	pyrazinamide
clpC1	4039183	c.1522T>C	synonymous_variant	0.83	pyrazinamide
clpC1	4039187	c.1518G>C	synonymous_variant	0.79	pyrazinamide
clpC1	4039190	c.1515C>G	synonymous_variant	0.78	pyrazinamide
clpC1	4039208	c.1497C>G	synonymous_variant	0.7	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	0.75	pyrazinamide	Not assoc w R - Interim
clpC1	4039268	c.1437C>G	synonymous_variant	0.73	pyrazinamide
clpC1	4039274	c.1431G>C	synonymous_variant	0.72	pyrazinamide	Not assoc w R - Interim
clpC1	4039286	c.1419T>C	synonymous_variant	0.71	pyrazinamide
clpC1	4039289	c.1416T>C	synonymous_variant	0.66	pyrazinamide
clpC1	4039295	c.1410A>C	synonymous_variant	0.66	pyrazinamide
clpC1	4039298	c.1407T>C	synonymous_variant	0.66	pyrazinamide
clpC1	4039319	c.1386T>C	synonymous_variant	0.64	pyrazinamide	Not assoc w R - Interim
clpC1	4039322	c.1383T>C	synonymous_variant	0.64	pyrazinamide
clpC1	4039328	c.1377A>G	synonymous_variant	0.61	pyrazinamide
clpC1	4039334	c.1371G>C	synonymous_variant	0.61	pyrazinamide
clpC1	4039337	p.Thr456Gln	missense_variant	0.59	pyrazinamide
clpC1	4039364	c.1341C>G	synonymous_variant	0.56	pyrazinamide
clpC1	4039388	c.1317C>A	synonymous_variant	0.62	pyrazinamide
clpC1	4039391	c.1314T>G	synonymous_variant	0.59	pyrazinamide
clpC1	4039409	c.1296T>C	synonymous_variant	0.59	pyrazinamide
clpC1	4039412	c.1293T>G	synonymous_variant	0.58	pyrazinamide
clpC1	4039430	c.1275T>C	synonymous_variant	0.64	pyrazinamide
clpC1	4039442	c.1263A>G	synonymous_variant	0.65	pyrazinamide
clpC1	4039448	c.1257A>G	synonymous_variant	0.65	pyrazinamide	Not assoc w R - Interim
clpC1	4039484	c.1221T>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039493	c.1212C>T	synonymous_variant	0.65	pyrazinamide	Not assoc w R - Interim
clpC1	4039517	c.1188C>G	synonymous_variant	0.64	pyrazinamide
clpC1	4039524	p.Phe394Tyr	missense_variant	0.64	pyrazinamide
clpC1	4039526	c.1179G>C	synonymous_variant	0.64	pyrazinamide
clpC1	4039532	c.1173C>T	synonymous_variant	0.64	pyrazinamide
clpC1	4039547	c.1158C>G	synonymous_variant	0.67	pyrazinamide
clpC1	4039553	c.1152C>G	synonymous_variant	0.65	pyrazinamide
clpC1	4039562	c.1143C>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039576	p.Ala377Ser	missense_variant	0.66	pyrazinamide
clpC1	4039577	c.1128T>C	synonymous_variant	0.66	pyrazinamide	Not assoc w R - Interim
clpC1	4039586	c.1119G>C	synonymous_variant	0.65	pyrazinamide
clpC1	4039610	c.1095G>C	synonymous_variant	0.67	pyrazinamide
clpC1	4039616	c.1089G>C	synonymous_variant	0.65	pyrazinamide
clpC1	4039622	c.1083C>G	synonymous_variant	0.66	pyrazinamide
clpC1	4039682	c.1023C>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039685	c.1020C>T	synonymous_variant	0.68	pyrazinamide
clpC1	4039724	c.981A>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039748	c.957G>C	synonymous_variant	0.67	pyrazinamide
clpC1	4039751	c.954A>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039757	c.948A>G	synonymous_variant	0.66	pyrazinamide
clpC1	4039760	c.945T>C	synonymous_variant	0.66	pyrazinamide
clpC1	4039769	c.936C>G	synonymous_variant	0.72	pyrazinamide
clpC1	4039778	c.927A>G	synonymous_variant	0.72	pyrazinamide
clpC1	4039781	c.924G>C	synonymous_variant	0.72	pyrazinamide
clpC1	4039787	c.916_918delTCGinsAGC	synonymous_variant	0.72	pyrazinamide
clpC1	4039793	c.912C>G	synonymous_variant	0.73	pyrazinamide
clpC1	4039817	c.888A>T	synonymous_variant	0.72	pyrazinamide
clpC1	4039820	c.885T>G	synonymous_variant	0.72	pyrazinamide
clpC1	4039831	c.874T>C	synonymous_variant	0.69	pyrazinamide
clpC1	4039832	c.873C>G	synonymous_variant	0.69	pyrazinamide
clpC1	4039850	c.855T>C	synonymous_variant	0.71	pyrazinamide
clpC1	4039865	c.840T>C	synonymous_variant	0.71	pyrazinamide
clpC1	4039898	c.807C>G	synonymous_variant	0.63	pyrazinamide
clpC1	4039904	c.801A>G	synonymous_variant	0.61	pyrazinamide
clpC1	4039928	c.775_777delAGCinsTCG	synonymous_variant	0.53	pyrazinamide
clpC1	4039931	c.774T>C	synonymous_variant	0.54	pyrazinamide
clpC1	4039946	c.759A>T	synonymous_variant	0.53	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	0.52	pyrazinamide
clpC1	4039958	c.747G>C	synonymous_variant	0.51	pyrazinamide
clpC1	4039979	c.726C>G	synonymous_variant	0.52	pyrazinamide
clpC1	4039996	p.Glu237Gln	missense_variant	0.48	pyrazinamide
clpC1	4040021	c.684A>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4040024	c.681A>G	synonymous_variant	0.5	pyrazinamide
clpC1	4040033	c.672G>C	synonymous_variant	0.5	pyrazinamide
clpC1	4040036	c.669C>G	synonymous_variant	0.5	pyrazinamide
clpC1	4040090	c.613_615delTCTinsAGC	synonymous_variant	0.38	pyrazinamide
clpC1	4040093	c.612C>G	synonymous_variant	0.37	pyrazinamide	Not assoc w R - Interim
clpC1	4040105	c.600C>G	synonymous_variant	0.38	pyrazinamide
clpC1	4040147	c.558A>G	synonymous_variant	0.4	pyrazinamide	Not assoc w R - Interim
clpC1	4040153	c.552A>G	synonymous_variant	0.41	pyrazinamide
clpC1	4040162	c.543G>C	synonymous_variant	0.41	pyrazinamide	Not assoc w R - Interim
clpC1	4040165	c.540G>C	synonymous_variant	0.42	pyrazinamide
clpC1	4040168	c.537G>C	synonymous_variant	0.43	pyrazinamide
clpC1	4040171	c.534C>G	synonymous_variant	0.44	pyrazinamide
clpC1	4040201	c.504C>G	synonymous_variant	0.5	pyrazinamide
clpC1	4040207	c.498T>C	synonymous_variant	0.5	pyrazinamide
clpC1	4040210	c.495G>A	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4040213	c.490_492delTCTinsAGC	synonymous_variant	0.5	pyrazinamide
clpC1	4040225	c.480A>C	synonymous_variant	0.53	pyrazinamide
clpC1	4040228	c.477G>C	synonymous_variant	0.55	pyrazinamide
clpC1	4040234	c.471C>G	synonymous_variant	0.57	pyrazinamide
clpC1	4040237	c.468C>T	synonymous_variant	0.57	pyrazinamide
clpC1	4040249	c.456A>G	synonymous_variant	0.59	pyrazinamide
clpC1	4040264	c.441C>T	synonymous_variant	0.55	pyrazinamide	Not assoc w R - Interim
clpC1	4040267	c.438A>G	synonymous_variant	0.56	pyrazinamide	Not assoc w R - Interim
clpC1	4040273	c.432T>C	synonymous_variant	0.55	pyrazinamide	Not assoc w R - Interim
clpC1	4040354	c.351A>G	synonymous_variant	0.54	pyrazinamide
clpC1	4040363	c.342A>C	synonymous_variant	0.53	pyrazinamide
clpC1	4040369	c.336C>G	synonymous_variant	0.5	pyrazinamide
clpC1	4040380	c.325T>C	synonymous_variant	0.49	pyrazinamide
clpC1	4040387	c.318A>G	synonymous_variant	0.46	pyrazinamide
clpC1	4040393	c.312G>C	synonymous_variant	0.49	pyrazinamide	Not assoc w R - Interim
clpC1	4040411	c.294T>C	synonymous_variant	0.49	pyrazinamide	Not assoc w R - Interim
clpC1	4040423	c.282A>G	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4040426	c.279T>C	synonymous_variant	0.49	pyrazinamide
clpC1	4040431	c.274T>C	synonymous_variant	0.5	pyrazinamide
clpC1	4040444	c.261C>G	synonymous_variant	0.49	pyrazinamide
clpC1	4040450	c.255A>G	synonymous_variant	0.49	pyrazinamide	Not assoc w R - Interim
clpC1	4040459	c.246C>G	synonymous_variant	0.45	pyrazinamide
clpC1	4040465	c.240T>C	synonymous_variant	0.48	pyrazinamide
clpC1	4040471	c.234T>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4040477	c.228G>A	synonymous_variant	0.49	pyrazinamide
clpC1	4040480	c.225T>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4040522	c.183T>C	synonymous_variant	0.53	pyrazinamide	Not assoc w R - Interim
clpC1	4040528	c.177G>C	synonymous_variant	0.51	pyrazinamide
clpC1	4040531	c.174T>C	synonymous_variant	0.51	pyrazinamide
clpC1	4040534	c.171A>G	synonymous_variant	0.51	pyrazinamide	Not assoc w R - Interim
clpC1	4040546	c.159G>C	synonymous_variant	0.47	pyrazinamide
clpC1	4040551	c.154T>C	synonymous_variant	0.46	pyrazinamide	Not assoc w R - Interim
clpC1	4040561	c.144A>G	synonymous_variant	0.42	pyrazinamide
clpC1	4040570	c.135C>G	synonymous_variant	0.41	pyrazinamide
clpC1	4040573	c.132T>G	synonymous_variant	0.41	pyrazinamide
clpC1	4040579	c.126A>G	synonymous_variant	0.4	pyrazinamide
clpC1	4040582	c.123G>C	synonymous_variant	0.4	pyrazinamide	Not assoc w R - Interim
clpC1	4040585	c.120A>G	synonymous_variant	0.41	pyrazinamide
clpC1	4040588	c.117T>C	synonymous_variant	0.41	pyrazinamide
clpC1	4040596	c.109C>T	synonymous_variant	0.38	pyrazinamide
clpC1	4040597	c.108C>T	synonymous_variant	0.39	pyrazinamide
clpC1	4040600	c.103_105delTTAinsCG	frameshift_variant&missense_variant	0.39	pyrazinamide
clpC1	4040603	c.102T>G	synonymous_variant	0.4	pyrazinamide
clpC1	4040606	c.99T>C	synonymous_variant	0.4	pyrazinamide
clpC1	4040644	c.61A>C	synonymous_variant	0.41	pyrazinamide
clpC1	4040654	c.51G>A	synonymous_variant	0.38	pyrazinamide
clpC1	4040657	c.48T>G	synonymous_variant	0.38	pyrazinamide	Not assoc w R - Interim
clpC1	4040662	c.43C>T	synonymous_variant	0.38	pyrazinamide	Not assoc w R - Interim
clpC1	4040699	c.6C>T	synonymous_variant	0.29	pyrazinamide
clpC1	4040711	c.-7G>A	upstream_gene_variant	0.3	pyrazinamide
panD	4044677	c.-396T>C	upstream_gene_variant	0.44	pyrazinamide
panD	4044682	c.-401C>A	upstream_gene_variant	0.42	pyrazinamide
panD	4044688	c.-407T>C	upstream_gene_variant	0.42	pyrazinamide
panD	4044692	c.-411G>C	upstream_gene_variant	0.42	pyrazinamide
panD	4044700	c.-419C>A	upstream_gene_variant	0.47	pyrazinamide
panD	4044704	c.-423G>T	upstream_gene_variant	0.47	pyrazinamide
panD	4044712	c.-431C>A	upstream_gene_variant	0.48	pyrazinamide
panD	4044737	c.-456T>C	upstream_gene_variant	0.43	pyrazinamide
panD	4044746	c.-467_-465delGTGinsAC	upstream_gene_variant	0.4	pyrazinamide
panD	4044749	c.-468G>A	upstream_gene_variant	0.39	pyrazinamide
panD	4044752	c.-471T>C	upstream_gene_variant	0.4	pyrazinamide
panD	4044755	c.-474G>C	upstream_gene_variant	0.45	pyrazinamide
panD	4044779	c.-500_-498delCTAinsTGC	upstream_gene_variant	0.5	pyrazinamide
panD	4044788	c.-507G>C	upstream_gene_variant	0.49	pyrazinamide
panD	4044809	c.-528C>G	upstream_gene_variant	0.51	pyrazinamide
panD	4044812	c.-531A>G	upstream_gene_variant	0.49	pyrazinamide
panD	4044818	c.-537G>C	upstream_gene_variant	0.49	pyrazinamide
panD	4044821	c.-540C>G	upstream_gene_variant	0.47	pyrazinamide
panD	4044830	c.-549C>G	upstream_gene_variant	0.49	pyrazinamide
panD	4044833	c.-552A>G	upstream_gene_variant	0.5	pyrazinamide
panD	4044844	c.-563T>C	upstream_gene_variant	0.46	pyrazinamide
panD	4044848	c.-567T>C	upstream_gene_variant	0.45	pyrazinamide
panD	4044854	c.-573A>G	upstream_gene_variant	0.42	pyrazinamide
panD	4044871	c.-590C>T	upstream_gene_variant	0.42	pyrazinamide
panD	4044872	c.-591C>T	upstream_gene_variant	0.42	pyrazinamide
panD	4044875	c.-596_-594delGACinsAT	upstream_gene_variant	0.44	pyrazinamide
panD	4044878	c.-597C>G	upstream_gene_variant	0.42	pyrazinamide
panD	4044881	c.-600T>C	upstream_gene_variant	0.42	pyrazinamide
panD	4044895	c.-614A>G	upstream_gene_variant	0.41	pyrazinamide
panD	4044896	c.-615T>G	upstream_gene_variant	0.41	pyrazinamide
panD	4044902	c.-621G>C	upstream_gene_variant	0.39	pyrazinamide
panD	4044908	c.-627T>C	upstream_gene_variant	0.39	pyrazinamide
panD	4044917	c.-636G>C	upstream_gene_variant	0.39	pyrazinamide
panD	4044923	c.-642A>G	upstream_gene_variant	0.39	pyrazinamide
panD	4044928	c.-647G>T	upstream_gene_variant	0.36	pyrazinamide
panD	4044929	c.-648G>C	upstream_gene_variant	0.36	pyrazinamide
panD	4044936	c.-655A>T	upstream_gene_variant	0.36	pyrazinamide
panD	4044954	c.-673C>T	upstream_gene_variant	0.36	pyrazinamide
panD	4044965	c.-684T>C	upstream_gene_variant	0.34	pyrazinamide
panD	4044974	c.-693C>G	upstream_gene_variant	0.33	pyrazinamide
panD	4044977	c.-696T>C	upstream_gene_variant	0.33	pyrazinamide
panD	4044983	c.-702G>C	upstream_gene_variant	0.33	pyrazinamide
panD	4044989	c.-708T>C	upstream_gene_variant	0.33	pyrazinamide
panD	4045000	c.-719A>C	upstream_gene_variant	0.27	pyrazinamide
panD	4045022	c.-741C>G	upstream_gene_variant	0.29	pyrazinamide
panD	4045025	c.-744C>G	upstream_gene_variant	0.29	pyrazinamide
panD	4045028	c.-747C>G	upstream_gene_variant	0.29	pyrazinamide
panD	4045034	c.-753A>T	upstream_gene_variant	0.29	pyrazinamide
glpK	4138352	c.1404C>G	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138360	c.1396T>C	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138373	c.1383C>G	synonymous_variant	0.55	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138377	p.Val460Ala	missense_variant	0.52	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
glpK	4138379	c.1377T>C	synonymous_variant	0.57	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138382	c.1374A>G	synonymous_variant	0.54	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138385	c.1371A>G	synonymous_variant	0.54	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138400	c.1356C>G	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138418	c.1338T>C	synonymous_variant	0.69	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138424	c.1332T>C	synonymous_variant	0.68	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138433	c.1323C>T	synonymous_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138451	c.1305T>C	synonymous_variant	0.66	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138463	c.1293C>A	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138472	c.1284G>C	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138478	c.1278T>C	synonymous_variant	0.65	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138481	c.1275G>C	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138490	c.1266G>T	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138493	c.1261_1263delCAGinsGA	frameshift_variant&missense_variant	0.65	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4138496	c.1260G>T	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138502	c.1254T>G	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138511	c.1245C>T	synonymous_variant	0.7	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138514	c.1242A>G	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138518	p.Glu413Ala	missense_variant	0.7	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138523	c.1233C>G	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138535	c.1221T>C	synonymous_variant	0.71	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138538	c.1218C>T	synonymous_variant	0.71	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138541	c.1215C>T	synonymous_variant	0.71	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					levofloxacin
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138547	c.1209C>T	synonymous_variant	0.73	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138568	c.1188A>G	synonymous_variant	0.71	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138571	c.1185C>G	synonymous_variant	0.71	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138583	c.1173G>C	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138586	c.1170C>T	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138594	p.Asn388Asp	missense_variant	0.63	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138606	c.1150T>C	synonymous_variant	0.61	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138631	c.1125C>G	synonymous_variant	0.58	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138634	c.1122G>T	synonymous_variant	0.54	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138643	c.1113A>C	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138664	c.1092G>C	synonymous_variant	0.44	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138667	c.1089G>C	synonymous_variant	0.44	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138670	c.1086G>C	synonymous_variant	0.44	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138679	c.1075_1077delATGinsGC	frameshift_variant&missense_variant	0.43	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4138695	p.Pro354Asp	missense_variant	0.35	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138703	c.1053C>G	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138706	c.1050C>G	synonymous_variant	0.4	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
embC	4238986	c.-877_-876delCAinsAG	upstream_gene_variant	0.29	ethambutol
embC	4238999	c.-864C>G	upstream_gene_variant	0.3	ethambutol	Uncertain significance
embC	4239012	c.-851_-849delTCCinsAG	upstream_gene_variant	0.3	ethambutol
embC	4239025	c.-838_-837delCGinsTC	upstream_gene_variant	0.26	ethambutol
embC	4239027	c.-836A>G	upstream_gene_variant	0.26	ethambutol
embC	4239032	c.-831T>C	upstream_gene_variant	0.25	ethambutol	Uncertain significance
embC	4239033	c.-830C>A	upstream_gene_variant	0.25	ethambutol
embC	4239036	c.-827_-826delCTinsGC	upstream_gene_variant	0.25	ethambutol
embC	4239057	c.-806A>C	upstream_gene_variant	0.29	ethambutol
embC	4239065	c.-798G>C	upstream_gene_variant	0.29	ethambutol
embC	4239068	c.-795A>C	upstream_gene_variant	0.29	ethambutol
embC	4239069	c.-794_-792delTCAinsGG	upstream_gene_variant	0.29	ethambutol
embC	4239076	c.-787C>T	upstream_gene_variant	0.29	ethambutol
embC	4239079	c.-784_-783delCAinsGC	upstream_gene_variant	0.29	ethambutol
embC	4239083	c.-780C>G	upstream_gene_variant	0.29	ethambutol
embC	4239125	c.-738C>G	upstream_gene_variant	0.29	ethambutol
embC	4240123	c.261C>G	synonymous_variant	0.45	ethambutol
embC	4240141	c.279A>G	synonymous_variant	0.43	ethambutol
embC	4240148	c.288_291delATCG	frameshift_variant	0.45	ethambutol
embC	4240155	p.Gln98Pro	missense_variant	0.43	ethambutol
embC	4240157	c.295_298delAACAinsGGGCAACC	frameshift_variant&missense_variant	0.48	ethambutol
embC	4240183	c.321A>G	synonymous_variant	0.42	ethambutol
embC	4240204	c.342T>C	synonymous_variant	0.34	ethambutol	Not assoc w R - Interim
embC	4240210	c.348C>G	synonymous_variant	0.33	ethambutol
embC	4240216	c.354T>C	synonymous_variant	0.36	ethambutol
embC	4240229	c.367_369delCTGinsAC	frameshift_variant&missense_variant	0.31	ethambutol
embC	4240232	p.Gln124Val	missense_variant	0.31	ethambutol
embC	4240258	c.396T>G	synonymous_variant	0.31	ethambutol
embC	4240267	c.405T>C	synonymous_variant	0.24	ethambutol
embC	4240270	c.408T>C	synonymous_variant	0.24	ethambutol
embC	4240277	p.Leu139Val	missense_variant	0.23	ethambutol
embC	4240632	p.Met257Thr	missense_variant	0.44	ethambutol
embC	4240642	c.780G>C	synonymous_variant	0.56	ethambutol
embC	4240645	c.783G>C	synonymous_variant	0.57	ethambutol
embC	4240654	c.792C>T	synonymous_variant	0.69	ethambutol
embC	4240657	c.795G>C	synonymous_variant	0.72	ethambutol
embC	4240671	p.Thr270Ile	missense_variant	0.71	ethambutol	Not assoc w R
embC	4240678	c.816T>G	synonymous_variant	0.65	ethambutol
embC	4240685	c.823_825delACCinsGG	frameshift_variant&missense_variant	0.67	ethambutol
embC	4240693	c.831T>C	synonymous_variant	0.67	ethambutol
embC	4240706	p.Val282Thr	missense_variant	0.64	ethambutol
embC	4240726	c.864G>C	synonymous_variant	0.63	ethambutol	Not assoc w R - Interim
embC	4240780	c.918T>C	synonymous_variant	0.56	ethambutol
embC	4240783	c.921G>C	synonymous_variant	0.58	ethambutol
embC	4240789	c.927T>C	synonymous_variant	0.58	ethambutol
embC	4240819	c.957A>G	synonymous_variant	0.51	ethambutol
embC	4240831	c.969T>G	synonymous_variant	0.55	ethambutol
embC	4240867	c.1005T>G	synonymous_variant	0.64	ethambutol
embC	4240870	c.1008T>C	synonymous_variant	0.64	ethambutol
embC	4240879	c.1017G>C	synonymous_variant	0.62	ethambutol
embC	4240880	p.Ala340Thr	missense_variant	0.61	ethambutol	Uncertain significance
embC	4240885	c.1023T>C	synonymous_variant	0.61	ethambutol
embC	4240897	c.1035C>G	synonymous_variant	0.58	ethambutol	Not assoc w R
embC	4240900	c.1038A>G	synonymous_variant	0.58	ethambutol
embC	4240919	c.1057_1059delCTCinsTG	frameshift_variant&missense_variant	0.53	ethambutol
embC	4240936	c.1074A>G	synonymous_variant	0.55	ethambutol
embC	4240945	c.1083T>C	synonymous_variant	0.56	ethambutol
embC	4240951	c.1089C>G	synonymous_variant	0.53	ethambutol
embC	4240954	p.Ile364Met	missense_variant	0.53	ethambutol
embC	4240957	c.1095C>G	synonymous_variant	0.5	ethambutol
embC	4240966	c.1104G>T	synonymous_variant	0.54	ethambutol	Not assoc w R - Interim
embC	4240979	p.Thr373Gln	missense_variant	0.47	ethambutol
embC	4240983	p.Ser374Asn	missense_variant	0.47	ethambutol
embC	4240990	c.1128A>G	synonymous_variant	0.51	ethambutol
embC	4240996	c.1134G>C	synonymous_variant	0.51	ethambutol
embC	4241017	c.1155T>C	synonymous_variant	0.57	ethambutol
embC	4241023	c.1161T>G	synonymous_variant	0.56	ethambutol
embC	4241026	c.1164C>G	synonymous_variant	0.54	ethambutol
embC	4241035	c.1173G>A	synonymous_variant	0.53	ethambutol
embC	4241050	c.1188T>G	synonymous_variant	0.53	ethambutol
embC	4241104	c.1242G>A	synonymous_variant	0.48	ethambutol	Not assoc w R - Interim
embC	4241107	c.1245G>C	synonymous_variant	0.47	ethambutol
embC	4241137	c.1275G>C	synonymous_variant	0.46	ethambutol
embC	4241140	c.1278A>G	synonymous_variant	0.42	ethambutol	Not assoc w R - Interim
embC	4241141	p.Ile427Val	missense_variant	0.42	ethambutol	Uncertain significance
embC	4241158	c.1296T>C	synonymous_variant	0.47	ethambutol
embC	4241161	c.1299C>G	synonymous_variant	0.47	ethambutol	Not assoc w R - Interim
embC	4241162	c.1300T>C	synonymous_variant	0.47	ethambutol
embC	4241203	c.1341T>C	synonymous_variant	0.45	ethambutol
embC	4241230	c.1368A>G	synonymous_variant	0.33	ethambutol
embC	4241233	c.1371G>C	synonymous_variant	0.32	ethambutol
embC	4241236	c.1374C>G	synonymous_variant	0.32	ethambutol
embC	4241374	c.1512T>C	synonymous_variant	0.35	ethambutol
embC	4241380	c.1518A>C	synonymous_variant	0.35	ethambutol
embC	4241394	p.Lys511Ser	missense_variant	0.35	ethambutol
embC	4241473	c.1611G>A	synonymous_variant	0.36	ethambutol
embC	4241479	c.1617C>G	synonymous_variant	0.32	ethambutol
embC	4241480	c.1618T>C	synonymous_variant	0.32	ethambutol
embC	4241488	c.1626G>C	synonymous_variant	0.36	ethambutol
embC	4241500	c.1638A>G	synonymous_variant	0.38	ethambutol
embC	4241501	c.1639_1641delTCGinsAC	frameshift_variant&missense_variant	0.38	ethambutol
embC	4241506	c.1644G>C	synonymous_variant	0.38	ethambutol
embC	4241518	c.1656A>G	synonymous_variant	0.41	ethambutol
embC	4241521	c.1659T>C	synonymous_variant	0.38	ethambutol	Not assoc w R - Interim
embC	4241530	c.1668C>A	synonymous_variant	0.4	ethambutol
embC	4241536	c.1674A>C	synonymous_variant	0.4	ethambutol
embC	4241539	c.1677T>C	synonymous_variant	0.4	ethambutol	Not assoc w R - Interim
embC	4241545	c.1683T>C	synonymous_variant	0.4	ethambutol
embC	4241546	c.1684_1686delGCTinsAC	frameshift_variant&missense_variant	0.42	ethambutol
embC	4241551	c.1689A>G	synonymous_variant	0.4	ethambutol
embC	4241560	c.1698C>G	synonymous_variant	0.4	ethambutol
embC	4241567	p.Ile569Val	missense_variant	0.42	ethambutol
embC	4241572	c.1710C>G	synonymous_variant	0.42	ethambutol
embC	4241578	c.1716G>C	synonymous_variant	0.42	ethambutol
embC	4241584	c.1722T>C	synonymous_variant	0.43	ethambutol
embC	4241587	c.1725C>G	synonymous_variant	0.43	ethambutol
embC	4241591	p.Leu577Val	missense_variant	0.43	ethambutol
embC	4241611	c.1749G>C	synonymous_variant	0.41	ethambutol
embC	4242643	c.2781C>T	synonymous_variant	0.88	ethambutol	Not assoc w R
embC	4242712	c.2850G>A	synonymous_variant	0.21	ethambutol	Not assoc w R - Interim
embC	4242803	p.Val981Leu	missense_variant	0.76	ethambutol	Not assoc w R
embA	4242859	c.-374C>T	upstream_gene_variant	0.25	ethambutol
embA	4242862	c.-371A>G	upstream_gene_variant	0.27	ethambutol
embC	4242863	p.Tyr1001Asn	missense_variant	0.27	ethambutol
embA	4244276	c.1044A>C	synonymous_variant	0.35	ethambutol
embA	4244284	p.Pro351Arg	missense_variant	0.35	ethambutol
embA	4244298	p.Ser356Ala	missense_variant	0.41	ethambutol
embA	4244309	c.1077C>G	synonymous_variant	0.41	ethambutol
embA	4244312	c.1080T>G	synonymous_variant	0.41	ethambutol	Not assoc w R - Interim
embA	4244315	c.1083G>C	synonymous_variant	0.41	ethambutol
embA	4244324	c.1092T>G	synonymous_variant	0.39	ethambutol
embA	4244327	c.1095T>C	synonymous_variant	0.39	ethambutol
embA	4244337	c.1105_1107delCTGinsGC	frameshift_variant&missense_variant	0.37	ethambutol	Uncertain significance
embA	4244340	c.1108_1110delTCCinsGG	frameshift_variant&missense_variant	0.37	ethambutol	Uncertain significance
embA	4244366	c.1134C>G	synonymous_variant	0.35	ethambutol	Not assoc w R - Interim
embA	4244372	c.1140T>G	synonymous_variant	0.38	ethambutol
embA	4244378	c.1146G>A	synonymous_variant	0.35	ethambutol	Not assoc w R - Interim
embA	4244396	c.1164T>C	synonymous_variant	0.32	ethambutol
embA	4245038	c.1806C>T	synonymous_variant	0.57	ethambutol
embA	4245056	c.1824C>G	synonymous_variant	0.58	ethambutol
embA	4245077	c.1845G>C	synonymous_variant	0.57	ethambutol
embA	4245083	c.1851A>C	synonymous_variant	0.57	ethambutol
embA	4245089	c.1857G>C	synonymous_variant	0.48	ethambutol
embA	4245092	c.1860C>G	synonymous_variant	0.52	ethambutol
embA	4245101	c.1869G>C	synonymous_variant	0.54	ethambutol
embA	4245137	c.1905T>C	synonymous_variant	0.5	ethambutol
embA	4245149	c.1917C>G	synonymous_variant	0.52	ethambutol
embA	4245182	c.1950T>C	synonymous_variant	0.43	ethambutol
embA	4245194	c.1962G>C	synonymous_variant	0.37	ethambutol
embA	4245198	p.Leu656Ile	missense_variant	0.37	ethambutol
embA	4245206	c.1974A>G	synonymous_variant	0.38	ethambutol
embA	4245207	c.1975T>C	synonymous_variant	0.38	ethambutol
embA	4245215	c.1983A>G	synonymous_variant	0.4	ethambutol
embA	4245222	c.1990_1992delTATinsCG	frameshift_variant&missense_variant	0.36	ethambutol	Uncertain significance
embA	4245242	c.2010C>T	synonymous_variant	0.33	ethambutol	Not assoc w R - Interim
embA	4245245	c.2013C>G	synonymous_variant	0.35	ethambutol
embA	4245248	c.2016G>C	synonymous_variant	0.35	ethambutol
embA	4245257	c.2025A>G	synonymous_variant	0.35	ethambutol
embA	4245263	c.2031A>G	synonymous_variant	0.36	ethambutol	Not assoc w R - Interim
embA	4245268	p.Asn679Ser	missense_variant	0.35	ethambutol
embA	4245282	c.2050_2052delATCinsGG	frameshift_variant&missense_variant	0.32	ethambutol	Uncertain significance
embA	4245285	c.2053T>C	synonymous_variant	0.29	ethambutol
embA	4245290	c.2058C>G	synonymous_variant	0.27	ethambutol
embA	4245293	c.2061T>C	synonymous_variant	0.27	ethambutol	Not assoc w R - Interim
embA	4245296	c.2064G>C	synonymous_variant	0.27	ethambutol
embA	4245299	c.2067A>G	synonymous_variant	0.28	ethambutol
embA	4245315	p.Val695Thr	missense_variant	0.27	ethambutol
embA	4245326	c.2094C>G	synonymous_variant	0.3	ethambutol
embA	4245328	p.Ala699Val	missense_variant	0.29	ethambutol
embA	4245335	c.2103A>G	synonymous_variant	0.29	ethambutol
embA	4245340	p.Gly703Ala	missense_variant	0.28	ethambutol
embA	4245345	p.Met705Leu	missense_variant	0.26	ethambutol
embA	4245348	p.Ala706Thr	missense_variant	0.26	ethambutol
embA	4245355	p.Ala708Gly	missense_variant	0.26	ethambutol
embA	4245368	c.2136T>C	synonymous_variant	0.31	ethambutol
embA	4245377	c.2145T>G	synonymous_variant	0.27	ethambutol
embB	4245617	c.-897C>G	upstream_gene_variant	0.33	ethambutol
embB	4245620	c.-894T>C	upstream_gene_variant	0.31	ethambutol
embA	4245623	c.2391G>C	synonymous_variant	0.31	ethambutol	Not assoc w R - Interim
embB	4245626	c.-888G>C	upstream_gene_variant	0.33	ethambutol
embA	4245643	p.Ala804Val	missense_variant	0.39	ethambutol
embA	4245648	p.Ile806Tyr	missense_variant	0.35	ethambutol
embA	4245652	p.Thr807Ser	missense_variant	0.34	ethambutol
embB	4245659	c.-855C>G	upstream_gene_variant	0.4	ethambutol
embA	4245674	c.2442A>C	synonymous_variant	0.44	ethambutol	Not assoc w R - Interim
embB	4245677	c.-837G>C	upstream_gene_variant	0.44	ethambutol
embB	4245683	c.-831C>G	upstream_gene_variant	0.45	ethambutol
embB	4245689	c.-825C>G	upstream_gene_variant	0.47	ethambutol
embB	4245692	c.-822G>C	upstream_gene_variant	0.48	ethambutol
embA	4245693	p.Ile821Val	missense_variant	0.48	ethambutol
embB	4245701	c.-813G>C	upstream_gene_variant	0.57	ethambutol
embB	4245716	c.-798G>C	upstream_gene_variant	0.54	ethambutol
embB	4245725	c.-789A>C	upstream_gene_variant	0.56	ethambutol
embA	4245726	c.2494_2496delTTGinsCC	frameshift_variant&missense_variant	0.56	ethambutol	Uncertain significance
embB	4245737	c.-777A>C	upstream_gene_variant	0.54	ethambutol
embB	4245740	c.-774T>C	upstream_gene_variant	0.54	ethambutol
embB	4245764	c.-750G>C	upstream_gene_variant	0.54	ethambutol
embA	4245771	p.Asn847Ser	missense_variant	0.53	ethambutol	Uncertain significance
embA	4245807	c.2575_2577delTTAinsCG	frameshift_variant&missense_variant	0.48	ethambutol	Uncertain significance
embB	4247365	c.852A>C	synonymous_variant	0.56	ethambutol
embB	4247371	c.858C>G	synonymous_variant	0.56	ethambutol
embB	4247375	p.Leu288Val	missense_variant	0.56	ethambutol
embB	4247386	c.873T>C	synonymous_variant	0.58	ethambutol
embB	4247389	c.876C>G	synonymous_variant	0.61	ethambutol
embB	4247395	c.882C>G	synonymous_variant	0.63	ethambutol
embB	4247401	c.888T>C	synonymous_variant	0.63	ethambutol
embB	4247437	c.924A>G	synonymous_variant	0.7	ethambutol	Not assoc w R - Interim
embB	4247440	c.927C>G	synonymous_variant	0.71	ethambutol
embB	4247464	c.951C>G	synonymous_variant	0.74	ethambutol
embB	4247470	c.957T>C	synonymous_variant	0.74	ethambutol
embB	4247491	c.978G>C	synonymous_variant	0.77	ethambutol
embB	4247500	c.987C>G	synonymous_variant	0.81	ethambutol
embB	4247512	c.999T>C	synonymous_variant	0.81	ethambutol
embB	4247536	c.1023C>G	synonymous_variant	0.83	ethambutol
embB	4247554	c.1041T>C	synonymous_variant	0.72	ethambutol
embB	4247566	c.1053C>G	synonymous_variant	0.62	ethambutol
embB	4247567	c.1054C>T	synonymous_variant	0.62	ethambutol
embB	4247572	c.1059A>G	synonymous_variant	0.62	ethambutol
embB	4247579	p.Ala356Phe	missense_variant	0.62	ethambutol
embB	4247587	c.1074G>A	synonymous_variant	0.65	ethambutol
embB	4247588	c.1075_1077delCTAinsAC	frameshift_variant&missense_variant	0.65	ethambutol
embB	4247603	c.1090C>T	synonymous_variant	0.68	ethambutol
embB	4247611	c.1098G>C	synonymous_variant	0.68	ethambutol
embB	4247614	c.1101T>C	synonymous_variant	0.64	ethambutol	Not assoc w R - Interim
embB	4247629	c.1116C>G	synonymous_variant	0.46	ethambutol
embB	4247632	c.1119C>G	synonymous_variant	0.44	ethambutol
embB	4247635	c.1122G>A	synonymous_variant	0.43	ethambutol
embB	4247743	c.1230C>G	synonymous_variant	0.5	ethambutol
embB	4247746	c.1233C>A	synonymous_variant	0.5	ethambutol	Not assoc w R - Interim
embB	4247776	c.1263G>T	synonymous_variant	0.5	ethambutol
embB	4247779	c.1266C>G	synonymous_variant	0.48	ethambutol	Not assoc w R - Interim
embB	4247785	c.1272G>C	synonymous_variant	0.48	ethambutol
embB	4247800	c.1287A>C	synonymous_variant	0.57	ethambutol
embB	4247806	c.1293G>C	synonymous_variant	0.56	ethambutol
embB	4247819	c.1306_1308delGTTinsAC	frameshift_variant&missense_variant	0.54	ethambutol
embB	4247824	c.1311C>G	synonymous_variant	0.54	ethambutol
embB	4247830	c.1317A>C	synonymous_variant	0.53	ethambutol
embB	4247836	c.1323A>G	synonymous_variant	0.55	ethambutol	Not assoc w R - Interim
embB	4247842	c.1329T>C	synonymous_variant	0.6	ethambutol
embB	4247876	c.1363C>T	synonymous_variant	0.6	ethambutol
embB	4247881	c.1368G>C	synonymous_variant	0.6	ethambutol
embB	4247887	c.1374C>T	synonymous_variant	0.61	ethambutol	Not assoc w R - Interim
embB	4247890	c.1377C>T	synonymous_variant	0.59	ethambutol
embB	4247899	p.Met462Ile	missense_variant	0.59	ethambutol
embB	4247905	c.1392G>C	synonymous_variant	0.59	ethambutol	Not assoc w R - Interim
embB	4247909	c.1396T>C	synonymous_variant	0.59	ethambutol
embB	4247914	c.1401G>C	synonymous_variant	0.58	ethambutol	Not assoc w R - Interim
embB	4247920	c.1407T>G	synonymous_variant	0.52	ethambutol
embB	4247923	c.1410T>C	synonymous_variant	0.52	ethambutol
embB	4247926	c.1413C>G	synonymous_variant	0.52	ethambutol
embB	4247927	p.Leu472Val	missense_variant	0.5	ethambutol	Uncertain significance
embB	4247932	c.1419C>G	synonymous_variant	0.5	ethambutol
embB	4247938	c.1425G>C	synonymous_variant	0.5	ethambutol
embB	4247940	p.Leu476Trp	missense_variant	0.5	ethambutol
embB	4247945	c.1432T>C	synonymous_variant	0.52	ethambutol
embB	4247951	p.Ser480Ala	missense_variant	0.54	ethambutol
embB	4247956	c.1443G>C	synonymous_variant	0.52	ethambutol	Not assoc w R - Interim
embB	4247974	c.1461C>G	synonymous_variant	0.58	ethambutol
embB	4247977	c.1464C>G	synonymous_variant	0.57	ethambutol
embB	4247986	c.1473C>G	synonymous_variant	0.56	ethambutol
embB	4248007	c.1494C>G	synonymous_variant	0.48	ethambutol
embB	4248011	p.Ser500Ala	missense_variant	0.5	ethambutol
embB	4248035	p.Val508Ile	missense_variant	0.56	ethambutol
embB	4248041	p.Ala510Thr	missense_variant	0.5	ethambutol	Uncertain significance
embB	4248044	p.Lys511Ala	missense_variant	0.5	ethambutol
embB	4248052	c.1539G>A	synonymous_variant	0.5	ethambutol
embB	4248055	c.1542G>C	synonymous_variant	0.52	ethambutol
embB	4248064	c.1551G>C	synonymous_variant	0.54	ethambutol	Not assoc w R - Interim
embB	4248070	c.1557T>C	synonymous_variant	0.58	ethambutol
embB	4248085	c.1572T>C	synonymous_variant	0.55	ethambutol
embB	4248095	c.1582_1584delCTCinsTG	frameshift_variant&missense_variant	0.45	ethambutol
embB	4248118	c.1605T>C	synonymous_variant	0.48	ethambutol
embB	4248127	c.1614G>C	synonymous_variant	0.46	ethambutol
embB	4248133	c.1620C>G	synonymous_variant	0.45	ethambutol
embB	4248142	c.1629T>C	synonymous_variant	0.45	ethambutol
embB	4248143	c.1630T>C	synonymous_variant	0.45	ethambutol
embB	4248157	c.1644A>G	synonymous_variant	0.43	ethambutol	Not assoc w R - Interim
embB	4248206	c.1693_1695delAGCinsGG	frameshift_variant&missense_variant	0.44	ethambutol
embB	4248220	c.1707A>G	synonymous_variant	0.44	ethambutol	Not assoc w R - Interim
embB	4248241	c.1728C>T	synonymous_variant	0.43	ethambutol
embB	4248265	c.1752C>T	synonymous_variant	0.42	ethambutol
embB	4248266	c.1753C>T	synonymous_variant	0.42	ethambutol
embB	4248277	c.1764G>C	synonymous_variant	0.44	ethambutol
embB	4248298	c.1785C>T	synonymous_variant	0.48	ethambutol
embB	4248304	c.1791G>C	synonymous_variant	0.48	ethambutol
embB	4249417	c.2904A>G	synonymous_variant	0.32	ethambutol
embB	4249420	c.2907G>C	synonymous_variant	0.31	ethambutol
embB	4249423	p.Asp970Glu	missense_variant	0.31	ethambutol	Uncertain significance
embB	4249424	p.Leu971Met	missense_variant	0.31	ethambutol
embB	4249432	c.2919A>G	synonymous_variant	0.32	ethambutol
embB	4249441	c.2928A>G	synonymous_variant	0.36	ethambutol	Not assoc w R - Interim
embB	4249444	c.2931T>C	synonymous_variant	0.36	ethambutol
embB	4249447	c.2934G>C	synonymous_variant	0.38	ethambutol
embB	4249456	c.2943G>C	synonymous_variant	0.39	ethambutol
embB	4249469	p.Leu986Met	missense_variant	0.44	ethambutol
embB	4249483	c.2970C>G	synonymous_variant	0.48	ethambutol
embB	4249486	c.2973T>G	synonymous_variant	0.43	ethambutol
embB	4249487	c.2974T>C	synonymous_variant	0.46	ethambutol
embB	4249498	c.2985G>C	synonymous_variant	0.42	ethambutol
embB	4249521	p.Ala1003Val	missense_variant	0.38	ethambutol
embB	4249525	c.3012T>C	synonymous_variant	0.35	ethambutol	Not assoc w R - Interim
embB	4249528	c.3015C>G	synonymous_variant	0.35	ethambutol
embB	4249529	p.Ile1006Val	missense_variant	0.35	ethambutol
embB	4249532	p.Ala1007Thr	missense_variant	0.35	ethambutol	Uncertain significance
embB	4249537	c.3024A>G	synonymous_variant	0.35	ethambutol
embB	4249543	c.3030G>C	synonymous_variant	0.36	ethambutol
embB	4249558	c.3045A>C	synonymous_variant	0.33	ethambutol
embB	4249564	c.3051C>T	synonymous_variant	0.32	ethambutol
embB	4249568	c.3055_3057delTCGinsAC	frameshift_variant&missense_variant	0.28	ethambutol
embB	4249573	c.3060T>C	synonymous_variant	0.28	ethambutol
embB	4249580	p.Leu1023Met	missense_variant	0.28	ethambutol
embB	4249594	c.3081G>C	synonymous_variant	0.29	ethambutol
embB	4249600	c.3087A>G	synonymous_variant	0.3	ethambutol
aftB	4269033	c.-197T>C	upstream_gene_variant	0.33	ethambutol
aftB	4269036	c.-200C>G	upstream_gene_variant	0.37	ethambutol
aftB	4269042	c.-206G>C	upstream_gene_variant	0.35	ethambutol
ubiA	4269075	c.757_759delATTinsGC	frameshift_variant&missense_variant	0.43	ethambutol
aftB	4269081	c.-245G>C	upstream_gene_variant	0.45	ethambutol
ubiA	4269088	p.Ala249Val	missense_variant	0.45	ethambutol	Uncertain significance
ubiA	4269097	c.736_737delTCinsGCGCG	missense_variant&conservative_inframe_insertion	0.45	ethambutol
ubiA	4269100	p.Gly245Glu	missense_variant	0.45	ethambutol
ubiA	4269104	p.Ser244Gly	missense_variant	0.45	ethambutol
ubiA	4269106	c.727delT	frameshift_variant	0.45	ethambutol
ubiA	4269109	c.723_724delCG	frameshift_variant	0.45	ethambutol
ubiA	4269117	p.Glu239Asp	missense_variant	0.48	ethambutol
aftB	4269123	c.-287T>C	upstream_gene_variant	0.45	ethambutol
aftB	4269132	c.-296G>C	upstream_gene_variant	0.42	ethambutol
ubiA	4269141	c.691_693delTTGinsGC	frameshift_variant&missense_variant	0.38	ethambutol
ubiA	4269144	c.690C>G	synonymous_variant	0.38	ethambutol	Not assoc w R - Interim
ubiA	4269149	p.Val229Leu	missense_variant	0.38	ethambutol	Uncertain significance
aftB	4269183	c.-347T>C	upstream_gene_variant	0.4	ethambutol
aftB	4269201	c.-365A>G	upstream_gene_variant	0.38	ethambutol
ubiA	4269209	p.Ser209Ala	missense_variant	0.32	ethambutol
ubiA	4269243	p.His197Gln	missense_variant	0.43	ethambutol
ethA	4327728	c.-255C>T	upstream_gene_variant	1.0	ethionamide