TB-Profiler result

Run: SRR6046382
Summary

Run ID: SRR6046382

Sample name:

Date: 2024-03-26T14:55:58.047573

Number of reads: 1144812

Percentage reads mapped: 37.3

Median coverage: 34.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: RR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.95
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.96
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
La1.7.X-unk4 M.bovis None 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.1021_1023delGACinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1162_1164delATGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1720_1722delGCCinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2491_2493delGCTinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.33 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.43 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303951 c.1021_1023delGACinsCG frameshift_variant&missense_variant 0.27 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.26 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304092 c.1162_1164delATGinsCC frameshift_variant&missense_variant 0.35 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304650 c.1720_1722delGCCinsCG frameshift_variant&missense_variant 0.46 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.3 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305421 c.2491_2493delGCTinsCG frameshift_variant&missense_variant 0.2 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 927 c.927G>A synonymous_variant 0.26 isoniazid
dnaA 933 c.933C>T synonymous_variant 0.26 isoniazid
dnaA 942 c.942C>T synonymous_variant 0.32 isoniazid
dnaA 948 c.948C>T synonymous_variant 0.33 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.35 isoniazid
dnaA 963 c.963C>T synonymous_variant 0.4 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.4 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.39 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 987 c.987C>T synonymous_variant 0.39 isoniazid
dnaA 990 c.990A>C synonymous_variant 0.4 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.48 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.49 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.47 isoniazid
dnaA 1020 c.1020C>G synonymous_variant 0.47 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.49 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.49 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.53 isoniazid
dnaA 1056 c.1056G>C synonymous_variant 0.52 isoniazid Not assoc w R - Interim
dnaA 1059 c.1059C>A synonymous_variant 0.51 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.46 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.42 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.43 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.3 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.3 isoniazid
gyrB 6121 c.882C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6145 c.906C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrB 6184 c.945C>T synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6190 c.951A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6202 c.963C>T synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6203 p.Ser322Ala missense_variant 0.43 levofloxacin
moxifloxacin
gyrB 6211 c.972G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6220 c.981G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6235 c.996C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6244 c.1005C>A synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6247 c.1008G>A synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.49 levofloxacin
moxifloxacin
gyrB 6358 c.1119C>G synonymous_variant 0.49 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6362 c.1123_1125delTTGinsCC frameshift_variant&missense_variant 0.49 levofloxacin Uncertain significance
moxifloxacin
gyrA 6367 c.-935C>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>A upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6571 c.-731T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6583 c.-719G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6592 c.-710C>A upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6595 c.1356G>A synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6610 c.-692C>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6628 c.-674C>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6646 c.-656C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6664 c.1425C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6766 c.-536G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.55 levofloxacin
moxifloxacin
gyrB 6805 c.1566G>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6850 c.-452C>T upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6866 c.-436C>T upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6991 c.-311C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6997 c.-305G>A upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7027 c.-275G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 7057 c.1818C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7060 c.1821T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7075 c.-227T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7076 c.1837_1839delCTAinsTG frameshift_variant&stop_gained 0.27 levofloxacin Uncertain significance
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7114 c.-188C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>T upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7136 c.1897_1899delTTGinsCA frameshift_variant&missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>A upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7171 c.-131C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 7178 c.1939_1941delTTGinsCC frameshift_variant&missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7192 c.-110G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7219 c.-83C>A upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7418 c.117C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7448 c.147G>A synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7490 c.189C>A synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7568 c.267C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7607 c.306C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7614 p.Leu105Met missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7619 c.318C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7775 c.474C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7796 c.495G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7797 c.496_498delCTAinsTG frameshift_variant&stop_gained 0.48 levofloxacin
moxifloxacin
gyrA 7811 c.510C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7814 c.513C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7832 c.531G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8253 p.Ile318Leu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8258 c.957G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8345 c.1044C>T synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8360 c.1059G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8369 c.1068G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8405 c.1104C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8433 p.Thr378Arg missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8534 c.1233G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8556 p.Ala419Gln missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8580 p.Ile427Val missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8588 c.1287G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8706 c.1405C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8730 c.1429_1431delGGGinsCA frameshift_variant&missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8791 c.1491G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8837 c.1536C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8927 c.1626G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8933 c.1632G>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8975 c.1674C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.41 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9016 p.Thr572Ser missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9056 c.1755C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9063 p.Ser588Ala missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9086 c.1785C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9089 c.1788G>A synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9113 c.1812C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9139 p.Gln613Arg missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.35 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9174 c.1873C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9192 c.1891C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9208 p.Lys636Arg missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9212 c.1911G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9218 p.Asp639Glu missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9245 c.1944C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9267 p.Asn656Gly missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9332 c.2031C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.36 levofloxacin
moxifloxacin
fgd1 491202 c.420G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491223 c.441C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491226 c.444C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491249 p.Arg156His missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491262 c.480C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491277 c.495G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491472 c.690A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491556 c.774G>A synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491559 c.777G>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575561 p.Met72Val missense_variant 0.25 ethionamide
isoniazid
mshA 575571 p.Ser75Thr missense_variant 0.25 ethionamide
isoniazid
mshA 575581 c.234C>T synonymous_variant 0.24 ethionamide
isoniazid
mshA 575582 c.235C>T synonymous_variant 0.24 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575596 c.249C>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575597 c.250_252delATCinsGG frameshift_variant&missense_variant 0.29 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575626 c.279C>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575629 c.282A>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575633 c.286_288delGCAinsAC frameshift_variant&missense_variant 0.38 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575645 p.Val100Thr missense_variant 0.36 ethionamide
isoniazid
mshA 575652 p.Arg102Gln missense_variant 0.41 ethionamide
isoniazid
mshA 575656 c.309G>C synonymous_variant 0.42 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575689 c.342G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575692 c.345G>T synonymous_variant 0.28 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.26 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.26 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575705 c.358_360delTTGinsCC frameshift_variant&missense_variant 0.28 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575713 c.366G>A synonymous_variant 0.3 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.4 ethionamide
isoniazid
mshA 575752 c.405G>A synonymous_variant 0.35 ethionamide
isoniazid Not assoc w R - Interim
mshA 575756 c.409C>T synonymous_variant 0.35 ethionamide
isoniazid
mshA 575788 c.441C>T synonymous_variant 0.33 ethionamide
isoniazid
mshA 575816 c.469C>T synonymous_variant 0.34 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575830 c.483C>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575869 c.522G>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.88 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620361 c.471C>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>T synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620647 p.Glu253Gln missense_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620676 c.786C>T synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620685 c.795G>A synonymous_variant 0.41 capreomycin Not assoc w R - Interim
amikacin
kanamycin Not assoc w R - Interim
ccsA 620694 c.804C>G synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620697 c.807C>T synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>C synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620754 c.864G>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620760 c.870C>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620766 c.876C>G synonymous_variant 0.5 capreomycin
amikacin
kanamycin
Rv0565c 656129 p.Tyr448His missense_variant 0.22 ethionamide
Rv0565c 656131 p.Pro447Leu missense_variant 0.22 ethionamide
Rv0565c 656136 c.1335G>C synonymous_variant 0.22 ethionamide
Rv0565c 656140 p.Lys444Leu missense_variant 0.21 ethionamide
Rv0565c 656145 c.1326T>C synonymous_variant 0.2 ethionamide
Rv0565c 656157 c.1314T>C synonymous_variant 0.2 ethionamide
Rv0565c 656495 p.Ala326Thr missense_variant 0.26 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
Rv0565c 656514 c.957C>T synonymous_variant 0.26 ethionamide
Rv0565c 656526 c.945G>A synonymous_variant 0.29 ethionamide
Rv0565c 656535 c.936C>A synonymous_variant 0.37 ethionamide
Rv0565c 656538 p.Ser311Glu missense_variant 0.31 ethionamide
Rv0565c 656542 p.Thr310Ser missense_variant 0.32 ethionamide
Rv0565c 656547 c.924C>G synonymous_variant 0.32 ethionamide
Rv0565c 656551 p.Asn307Val missense_variant 0.32 ethionamide
Rv0565c 656556 c.915G>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
Rv0565c 656582 c.889C>T synonymous_variant 0.38 ethionamide
Rv0565c 656583 c.888A>G synonymous_variant 0.38 ethionamide
Rv0565c 656589 c.882T>C synonymous_variant 0.38 ethionamide
Rv0565c 656611 p.Thr287Lys missense_variant 0.32 ethionamide
Rv0565c 656616 c.855C>T synonymous_variant 0.32 ethionamide
Rv0565c 656622 p.Glu283Asp missense_variant 0.23 ethionamide
Rv0565c 656627 p.Ile282Val missense_variant 0.23 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.94 ethionamide Uncertain significance
Rv0565c 657596 c.-126G>C upstream_gene_variant 0.34 ethionamide
Rv0565c 657602 c.-132C>A upstream_gene_variant 0.38 ethionamide
Rv0565c 657608 c.-138C>G upstream_gene_variant 0.37 ethionamide
Rv0565c 657626 c.-158_-156delCGCinsAAG upstream_gene_variant 0.39 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.37 ethionamide
Rv0565c 657640 c.-170A>T upstream_gene_variant 0.35 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.35 ethionamide
Rv0565c 657647 c.-177C>G upstream_gene_variant 0.38 ethionamide
Rv0565c 657659 c.-189G>A upstream_gene_variant 0.38 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.39 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.41 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.29 ethionamide
nusG 734439 c.186C>G synonymous_variant 0.25 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.25 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.26 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.26 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.27 rifampicin
nusG 734463 c.210G>A synonymous_variant 0.27 rifampicin
nusG 734466 c.213G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.29 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>A synonymous_variant 0.38 rifampicin
nusG 734514 c.261A>G synonymous_variant 0.34 rifampicin
nusG 734517 c.264G>A synonymous_variant 0.37 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.4 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.47 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.47 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760136 c.330G>A synonymous_variant 0.43 rifampicin
rpoB 760139 c.333A>C synonymous_variant 0.43 rifampicin
rpoB 760174 p.Tyr123Phe missense_variant 0.49 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.51 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.58 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.5 rifampicin
rpoB 760307 c.501T>G synonymous_variant 0.53 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.54 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.55 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.55 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.49 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.47 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760436 c.630C>G synonymous_variant 0.51 rifampicin
rpoB 760451 c.645C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760493 c.687C>T synonymous_variant 0.49 rifampicin
rpoB 760497 c.691C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.4 rifampicin Uncertain significance
rpoB 760526 c.720G>A synonymous_variant 0.41 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.4 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.39 rifampicin Uncertain significance
rpoB 760597 p.Thr264Ser missense_variant 0.36 rifampicin
rpoB 760604 p.Glu266Asp missense_variant 0.33 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760643 c.837G>A synonymous_variant 0.35 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760844 p.Gln346His missense_variant 0.44 rifampicin
rpoB 760845 p.Thr347Ala missense_variant 0.44 rifampicin
rpoB 760855 p.Thr350Lys missense_variant 0.42 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.44 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.48 rifampicin
rpoB 760916 c.1110C>G synonymous_variant 0.51 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.53 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.54 rifampicin
rpoB 760971 c.1165C>A synonymous_variant 0.51 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.53 rifampicin
rpoB 761006 c.1200C>T synonymous_variant 0.53 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.42 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.42 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.43 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>G synonymous_variant 0.41 rifampicin
rpoB 761150 c.1344A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.41 rifampicin
rpoB 761162 c.1356G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.39 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.34 rifampicin
rpoB 761183 c.1377T>C synonymous_variant 0.38 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.4 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.41 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.4 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761274 c.1468C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761314 p.Phe503Tyr missense_variant 0.39 rifampicin
rpoB 761324 c.1518C>T synonymous_variant 0.43 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761349 p.Asp515Asn missense_variant 0.36 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.4 rifampicin
rpoB 761405 c.1599C>T synonymous_variant 0.36 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.36 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.33 rifampicin
rpoB 761437 p.Ala544Glu missense_variant 0.35 rifampicin
rpoB 761441 c.1635C>T synonymous_variant 0.35 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.35 rifampicin
rpoB 761451 p.Val549Thr missense_variant 0.33 rifampicin
rpoB 761462 c.1656C>G synonymous_variant 0.35 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.31 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.25 rifampicin
rpoB 761486 c.1680C>G synonymous_variant 0.29 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.28 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.32 rifampicin
rpoB 761507 c.1701G>C synonymous_variant 0.29 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.35 rifampicin
rpoB 761603 c.1797C>G synonymous_variant 0.35 rifampicin
rpoB 761604 c.1798_1800delCTCinsTG frameshift_variant&missense_variant 0.34 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.37 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761640 c.1834C>T synonymous_variant 0.36 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>A synonymous_variant 0.31 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.23 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.29 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.33 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.34 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.36 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.37 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>G synonymous_variant 0.38 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.39 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.39 rifampicin
rpoB 761885 c.2079T>G synonymous_variant 0.42 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.45 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.44 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.43 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.46 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.45 rifampicin
rpoB 761916 p.Asp704His missense_variant 0.45 rifampicin
rpoB 761945 c.2139G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.53 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761997 c.2191_2193delCTGinsAC frameshift_variant&missense_variant 0.46 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.51 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762024 c.2218_2220delGTGinsAC frameshift_variant&missense_variant 0.46 rifampicin
rpoB 762050 c.2244G>A synonymous_variant 0.45 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762110 c.2304G>C synonymous_variant 0.46 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.46 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.44 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.41 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.41 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762192 c.2386C>T synonymous_variant 0.37 rifampicin
rpoB 762218 c.2412T>G synonymous_variant 0.38 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.37 rifampicin
rpoB 762257 c.2451C>A synonymous_variant 0.34 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.35 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762297 c.2491C>T synonymous_variant 0.35 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.4 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.44 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.42 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.4 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.35 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.28 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.28 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.27 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.25 rifampicin
rpoC 762482 c.-888C>T upstream_gene_variant 0.27 rifampicin
rpoB 762491 c.2685T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.31 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.31 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.4 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.4 rifampicin
rpoB 762537 c.2731_2733delTTGinsCC frameshift_variant&missense_variant 0.4 rifampicin
rpoC 762542 c.-828C>T upstream_gene_variant 0.4 rifampicin
rpoB 762548 c.2742C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762551 c.-819C>G upstream_gene_variant 0.42 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.41 rifampicin
rpoC 762605 c.-765T>C upstream_gene_variant 0.31 rifampicin
rpoB 762624 p.Val940Ile missense_variant 0.23 rifampicin
rpoB 762630 p.Ala942Thr missense_variant 0.21 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.37 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762814 p.Met1003Thr missense_variant 0.38 rifampicin Uncertain significance
rpoB 762818 c.3012C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.46 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.5 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.53 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.51 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.47 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.44 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.21 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.35 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.38 rifampicin Uncertain significance
rpoC 763441 c.72C>G synonymous_variant 0.42 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763489 c.120G>A synonymous_variant 0.52 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763552 c.183C>T synonymous_variant 0.59 rifampicin Not assoc w R
rpoC 763561 c.192G>A synonymous_variant 0.61 rifampicin
rpoC 763570 c.201G>T synonymous_variant 0.62 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>A synonymous_variant 0.54 rifampicin
rpoC 763609 c.240C>G synonymous_variant 0.52 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.52 rifampicin
rpoC 763654 c.285C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.39 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.39 rifampicin
rpoC 763726 c.357C>T synonymous_variant 0.39 rifampicin
rpoC 763727 c.358C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.38 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.38 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.38 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.35 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.35 rifampicin
rpoC 763781 p.Ser138Asp missense_variant 0.37 rifampicin
rpoC 763796 p.Met143Leu missense_variant 0.39 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.45 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763831 c.462A>G synonymous_variant 0.28 rifampicin
rpoC 763903 c.534G>A synonymous_variant 0.25 rifampicin
rpoC 763916 p.Glu183Gln missense_variant 0.25 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.32 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.49 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.5 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.51 rifampicin
rpoC 764027 p.Glu220Gln missense_variant 0.52 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.49 rifampicin
rpoC 764039 p.Ser224Asp missense_variant 0.47 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.49 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.5 rifampicin
rpoC 764068 c.699G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764071 c.702G>C synonymous_variant 0.44 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.49 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.49 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.48 rifampicin Uncertain significance
rpoC 764161 c.792G>C synonymous_variant 0.49 rifampicin
rpoC 764195 p.Ser276Ala missense_variant 0.55 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.55 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.54 rifampicin
rpoC 764209 c.840C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>T synonymous_variant 0.54 rifampicin
rpoC 764255 c.886C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764269 c.900G>T synonymous_variant 0.49 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764285 p.Gly306Ser missense_variant 0.43 rifampicin
rpoC 764317 c.948C>A synonymous_variant 0.33 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.31 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.27 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.39 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.46 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.43 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764570 c.1203_1204delGC frameshift_variant 0.39 rifampicin
rpoC 764577 c.1208_1209delCCinsGAGT frameshift_variant&stop_gained 0.36 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.38 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.39 rifampicin
rpoC 764680 c.1311G>A synonymous_variant 0.36 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.4 rifampicin
rpoC 764713 c.1344G>A synonymous_variant 0.45 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.49 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764770 c.1401G>A synonymous_variant 0.49 rifampicin
rpoC 764782 c.1413C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764812 c.1443C>G synonymous_variant 0.53 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764861 c.1492C>T synonymous_variant 0.54 rifampicin
rpoC 764875 c.1506C>G synonymous_variant 0.52 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.48 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.46 rifampicin
rpoC 764918 c.1549_1551delGTGinsAC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.43 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764986 c.1617C>T synonymous_variant 0.4 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.38 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.36 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.33 rifampicin
rpoC 765076 c.1707A>G synonymous_variant 0.37 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765122 c.1753C>T synonymous_variant 0.29 rifampicin
rpoC 765145 c.1776C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765361 c.1992C>G synonymous_variant 0.18 rifampicin
rpoC 765391 c.2022C>T synonymous_variant 0.38 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.39 rifampicin
rpoC 765404 p.Leu679Met missense_variant 0.37 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.33 rifampicin
rpoC 765415 c.2046G>C synonymous_variant 0.33 rifampicin
rpoC 765452 p.Ala695Thr missense_variant 0.43 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765544 c.2175C>G synonymous_variant 0.53 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.54 rifampicin
rpoC 765548 c.2179_2180delAGinsTC synonymous_variant 0.56 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765590 p.Arg741Asn missense_variant 0.65 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.65 rifampicin
rpoC 765611 p.His748Ala missense_variant 0.61 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765655 c.2286T>A synonymous_variant 0.57 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.51 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.52 rifampicin
rpoC 765781 p.Asp804Glu missense_variant 0.53 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.52 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.52 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.48 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.48 rifampicin
rpoC 765826 c.2457T>G synonymous_variant 0.46 rifampicin
rpoC 765835 c.2466C>A synonymous_variant 0.45 rifampicin
rpoC 765836 c.2467C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765865 c.2496C>T synonymous_variant 0.41 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 0.4 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.39 rifampicin Uncertain significance
rpoC 765883 c.2514C>G synonymous_variant 0.36 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.35 rifampicin
rpoC 765908 c.2539C>T synonymous_variant 0.3 rifampicin
rpoC 765937 c.2568T>G synonymous_variant 0.2 rifampicin
rpoC 765940 c.2571A>G synonymous_variant 0.2 rifampicin
rpoC 765943 c.2574G>A synonymous_variant 0.2 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.19 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766194 p.Gln942Arg missense_variant 0.23 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.22 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.29 rifampicin
rpoC 766402 c.3033C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.36 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.4 rifampicin
rpoC 766442 p.Thr1025Val missense_variant 0.39 rifampicin
rpoC 766445 c.3076_3078delGGTinsAC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.45 rifampicin
rpoC 766484 c.3115_3117delGTAinsAT frameshift_variant&missense_variant 0.47 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.51 rifampicin
rpoC 766518 p.Thr1050Ser missense_variant 0.53 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.55 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.52 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.54 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.52 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.54 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.55 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.63 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.63 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.56 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.63 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.67 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.69 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 0.34 rifampicin Not assoc w R
rpoC 766651 c.3282T>C synonymous_variant 0.56 rifampicin
rpoC 766652 p.Ser1095Thr missense_variant 0.56 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.56 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.57 rifampicin
rpoC 766684 c.3315C>G synonymous_variant 0.52 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.43 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.42 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.28 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.33 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.35 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766834 c.3465G>A synonymous_variant 0.42 rifampicin
rpoC 766843 c.3474T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.52 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.51 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.51 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.5 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.53 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.5 rifampicin
rpoC 766933 c.3564A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766942 c.3573C>A synonymous_variant 0.5 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.51 rifampicin
rpoC 766988 c.3619C>T synonymous_variant 0.47 rifampicin
rpoC 766996 c.3627C>G synonymous_variant 0.5 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.59 rifampicin
rpoC 767066 c.3697C>T synonymous_variant 0.62 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>A synonymous_variant 0.57 rifampicin
rpoC 767162 p.Asn1265Ala missense_variant 0.54 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.54 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767239 c.3870T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.3 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.28 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776009 c.2472A>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 776024 c.2457G>C synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 776030 c.2451G>A synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 776038 p.Ser815Ala missense_variant 0.22 clofazimine
bedaquiline
mmpL5 776040 p.Ala814Ser missense_variant 0.21 clofazimine
bedaquiline
mmpL5 776056 p.Val809Leu missense_variant 0.23 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 778588 p.Gln106His missense_variant 0.44 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781622 c.63C>T synonymous_variant 0.29 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781634 c.75G>A synonymous_variant 0.32 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.33 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.3 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.29 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.29 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.34 streptomycin
rpsL 781703 c.144G>A synonymous_variant 0.39 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.42 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.43 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.42 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.41 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.41 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.42 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.42 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.42 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.43 streptomycin
rpsL 781778 c.219C>T synonymous_variant 0.4 streptomycin
rpsL 781779 c.220C>T synonymous_variant 0.42 streptomycin
rpsL 781799 c.240G>C synonymous_variant 0.41 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.49 streptomycin
rpsL 781826 c.267C>T synonymous_variant 0.46 streptomycin Not assoc w R - Interim
rpsL 781832 c.273T>C synonymous_variant 0.47 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.5 streptomycin
rpsL 781856 c.297C>G synonymous_variant 0.44 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.42 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.42 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.43 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.46 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.47 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.48 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.47 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.48 streptomycin
rplC 800574 c.-235_-233delGTCinsAG upstream_gene_variant 0.18 linezolid
rplC 800579 c.-230C>G upstream_gene_variant 0.21 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.21 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.26 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.26 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.26 linezolid
rplC 800603 c.-206G>T upstream_gene_variant 0.28 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.31 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.32 linezolid
rplC 800630 c.-179G>C upstream_gene_variant 0.26 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.26 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.29 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800657 c.-152G>A upstream_gene_variant 0.28 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.28 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.27 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.23 linezolid
rplC 800726 c.-83G>A upstream_gene_variant 0.23 linezolid
rplC 801171 c.363A>G synonymous_variant 0.2 linezolid
rplC 801174 c.366T>C synonymous_variant 0.24 linezolid
rplC 801195 c.387G>C synonymous_variant 0.28 linezolid
rplC 801201 c.393C>T synonymous_variant 0.27 linezolid
rplC 801210 c.402T>G synonymous_variant 0.24 linezolid Not assoc w R - Interim
rplC 801216 c.408C>T synonymous_variant 0.23 linezolid
rplC 801222 c.414T>C synonymous_variant 0.23 linezolid
rplC 801228 c.420T>C synonymous_variant 0.23 linezolid
rplC 801231 c.423C>T synonymous_variant 0.23 linezolid
rplC 801234 c.426G>A synonymous_variant 0.22 linezolid
rplC 801237 c.429G>C synonymous_variant 0.23 linezolid
rplC 801246 c.438C>A synonymous_variant 0.21 linezolid
rplC 801249 c.441T>C synonymous_variant 0.22 linezolid
rplC 801252 c.444G>C synonymous_variant 0.22 linezolid
rplC 801255 c.447C>T synonymous_variant 0.23 linezolid
rplC 801258 c.450C>G synonymous_variant 0.23 linezolid
rplC 801264 c.456C>G synonymous_variant 0.21 linezolid Not assoc w R - Interim
rplC 801267 c.459A>C synonymous_variant 0.21 linezolid
rplC 801270 c.462T>C synonymous_variant 0.22 linezolid
rplC 801276 c.468G>A synonymous_variant 0.24 linezolid
rplC 801282 c.474G>C synonymous_variant 0.25 linezolid
rplC 801321 c.513C>T synonymous_variant 0.19 linezolid Not assoc w R - Interim
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303464 c.534A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303476 c.546G>C synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303557 c.627G>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303966 c.1036C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303974 c.1044C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304013 c.1083G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304020 p.His364Tyr missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304099 p.Gln390Pro missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304104 c.1174C>T synonymous_variant 0.39 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304111 p.Ala394Val missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304130 c.1200G>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304133 c.1203G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>A synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304157 c.1227G>A synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304163 c.1233G>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304166 c.1236A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304172 c.1242G>C synonymous_variant 0.32 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304173 p.Val415Thr missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304192 p.Ala421Val missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304481 c.1551T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304496 c.1566T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304517 c.1587C>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304532 c.1602G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304538 c.1608C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304655 c.1725C>T synonymous_variant 0.47 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304661 c.1731C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304665 c.1735C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304673 c.1743C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Ala missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304688 p.Asp586Glu missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304698 p.Glu590Gln missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304958 c.2028T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305043 c.2113_2115delTCAinsAGC synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305081 c.2151G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305135 c.2205C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305162 c.2232C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305174 c.2244T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305177 c.2247A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305181 c.2251T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305186 c.2256C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305195 c.2265T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305210 c.2280G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305234 c.2304G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305237 c.2307A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305270 c.2340C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305313 p.Arg795Gly missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305324 c.2394G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305408 c.2478G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305420 c.2490C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305427 c.2497C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
sigE 1364661 c.249C>G synonymous_variant 0.22 pyrazinamide
sigE 1364676 c.264C>G synonymous_variant 0.22 pyrazinamide
sigE 1364679 c.267T>C synonymous_variant 0.22 pyrazinamide
sigE 1364688 c.276C>G synonymous_variant 0.26 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.26 pyrazinamide
sigE 1364697 c.285G>A synonymous_variant 0.3 pyrazinamide
sigE 1364706 c.294G>A synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
sigE 1364709 c.297T>C synonymous_variant 0.35 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.35 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.35 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.35 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.4 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.41 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.45 pyrazinamide
sigE 1364778 c.366G>T synonymous_variant 0.42 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.42 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.41 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.44 pyrazinamide
sigE 1364805 c.393C>A synonymous_variant 0.39 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.45 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.5 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
sigE 1364898 c.486C>T synonymous_variant 0.56 pyrazinamide
sigE 1364918 p.Asp169Ala missense_variant 0.43 pyrazinamide
sigE 1364952 c.540A>C synonymous_variant 0.39 pyrazinamide
sigE 1364956 c.544C>T synonymous_variant 0.38 pyrazinamide
sigE 1364960 p.Gly183Ala missense_variant 0.38 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.32 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.32 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.32 pyrazinamide
sigE 1364994 c.582G>C synonymous_variant 0.32 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.32 pyrazinamide
sigE 1365019 c.607C>T synonymous_variant 0.32 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.26 pyrazinamide
sigE 1365037 c.625C>T synonymous_variant 0.22 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80_81delTCinsCCTTT non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471929 n.84C>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476531 n.2874T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
inhA 1673946 c.-256C>G upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1673973 c.-229G>C upstream_gene_variant 0.5 ethionamide
isoniazid Uncertain significance
inhA 1674033 c.-169T>C upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1674036 c.-166G>A upstream_gene_variant 0.38 ethionamide
isoniazid
fabG1 1674037 p.Gln200Lys missense_variant 0.38 ethionamide
isoniazid
inhA 1674042 c.-160G>C upstream_gene_variant 0.39 ethionamide
isoniazid Uncertain significance
inhA 1674045 c.-157G>A upstream_gene_variant 0.36 ethionamide
isoniazid
fabG1 1674049 p.Gln204Glu missense_variant 0.36 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.38 ethionamide
isoniazid
fabG1 1674070 c.631_633delGTCinsAT frameshift_variant&missense_variant 0.35 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.32 ethionamide
isoniazid
inhA 1674256 p.Ser19Ala missense_variant 0.2 ethionamide
isoniazid Uncertain significance
inhA 1674279 c.78A>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674303 c.102C>A synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674312 c.111G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674313 p.Leu38Cys missense_variant 0.22 ethionamide
isoniazid
inhA 1674321 c.120G>T synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674342 c.141T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674343 p.Gln48Glu missense_variant 0.22 ethionamide
isoniazid
inhA 1674353 p.Thr51Ile missense_variant 0.18 ethionamide
isoniazid
inhA 1674789 c.588G>A synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674790 c.589C>T synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674813 c.612C>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674934 p.Leu245Val missense_variant 0.26 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1833559 c.18C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833560 p.Thr7Ser missense_variant 0.29 pyrazinamide
rpsA 1833568 c.27G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>C synonymous_variant 0.32 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.31 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.32 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.31 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833661 c.120A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833688 c.147C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833832 p.Glu97Asp missense_variant 0.26 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833871 c.330G>A synonymous_variant 0.27 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.29 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.33 pyrazinamide
rpsA 1833901 c.360G>A synonymous_variant 0.34 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.36 pyrazinamide
rpsA 1833916 c.375C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833922 c.381G>A synonymous_variant 0.44 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833937 c.396G>A synonymous_variant 0.48 pyrazinamide
rpsA 1833949 c.408T>A synonymous_variant 0.48 pyrazinamide
rpsA 1833952 c.411C>G synonymous_variant 0.49 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.56 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834009 c.468C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834165 c.624A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834169 c.628_630delACCinsGG frameshift_variant&missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834174 c.633C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834237 c.696C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.46 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834285 c.744G>A synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.52 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834381 c.840G>A synonymous_variant 0.5 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.48 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.46 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.39 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.48 pyrazinamide
rpsA 1834528 c.987T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834532 p.Val331Ile missense_variant 0.47 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834541 p.Pro334Ala missense_variant 0.45 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.5 pyrazinamide
rpsA 1834561 c.1020C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834570 p.Asp343Glu missense_variant 0.52 pyrazinamide
rpsA 1834572 p.Ala344Val missense_variant 0.51 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 0.54 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.51 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834702 p.Gln387His missense_variant 0.57 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.58 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.52 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.48 pyrazinamide
rpsA 1834761 p.Phe407Tyr missense_variant 0.47 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.47 pyrazinamide
tsnR 1853945 p.Val114Ile missense_variant 0.39 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102827 c.216C>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102836 c.207T>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102842 c.201A>G synonymous_variant 0.34 ethionamide
delamanid
isoniazid
ndh 2102848 c.195G>A synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102857 c.186T>C synonymous_variant 0.39 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102863 c.180C>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102866 c.177C>G synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102869 c.174G>T synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102872 c.171A>G synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102875 c.168C>T synonymous_variant 0.4 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102890 c.153C>T synonymous_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2102911 c.132G>C synonymous_variant 0.43 ethionamide
delamanid
isoniazid
ndh 2102929 c.114T>C synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102940 c.103C>A synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102953 c.90A>C synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102962 c.81A>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102965 c.78G>A synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102974 c.69G>A synonymous_variant 0.31 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155743 c.369G>C synonymous_variant 0.26 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.25 isoniazid
katG 2155755 c.357C>T synonymous_variant 0.28 isoniazid Not assoc w R - Interim
katG 2155785 c.327T>C synonymous_variant 0.4 isoniazid
katG 2155788 c.324C>T synonymous_variant 0.4 isoniazid
katG 2155794 p.Ala106Ser missense_variant 0.4 isoniazid
katG 2155806 c.306T>C synonymous_variant 0.32 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517938 c.-177C>G upstream_gene_variant 0.49 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.47 isoniazid
kasA 2517968 c.-147T>G upstream_gene_variant 0.39 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.37 isoniazid
kasA 2517983 c.-132T>C upstream_gene_variant 0.34 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.32 isoniazid
kasA 2517994 c.-121_-120delCCinsAA upstream_gene_variant 0.32 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.31 isoniazid
kasA 2518162 c.48G>C synonymous_variant 0.25 isoniazid
kasA 2518180 c.66G>A synonymous_variant 0.31 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.31 isoniazid
kasA 2518193 p.Pro27Ala missense_variant 0.31 isoniazid
kasA 2518204 c.90G>A synonymous_variant 0.36 isoniazid
kasA 2518220 c.106_108delCTGinsTA frameshift_variant&stop_gained 0.34 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.35 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.34 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.33 isoniazid
kasA 2518270 c.156C>G synonymous_variant 0.33 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.29 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.29 isoniazid
kasA 2518300 c.186T>C synonymous_variant 0.26 isoniazid
kasA 2518303 c.189C>T synonymous_variant 0.3 isoniazid
kasA 2518306 c.192C>G synonymous_variant 0.3 isoniazid
kasA 2518360 c.246C>T synonymous_variant 0.29 isoniazid
kasA 2518396 c.282A>C synonymous_variant 0.28 isoniazid
kasA 2518403 p.Ser97Ala missense_variant 0.29 isoniazid
kasA 2518413 p.Ser100Thr missense_variant 0.31 isoniazid
kasA 2518429 c.315A>G synonymous_variant 0.3 isoniazid
kasA 2518439 c.325_327delGCCinsTG frameshift_variant&missense_variant 0.29 isoniazid
kasA 2518444 c.330T>G synonymous_variant 0.29 isoniazid
kasA 2518447 c.333T>C synonymous_variant 0.29 isoniazid
kasA 2518448 p.Val112Ile missense_variant 0.29 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.26 isoniazid
kasA 2518462 c.348A>G synonymous_variant 0.26 isoniazid
kasA 2518465 c.351T>C synonymous_variant 0.28 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.29 isoniazid
kasA 2518475 c.361_363delAGGinsCA frameshift_variant&missense_variant 0.29 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.28 isoniazid
kasA 2518486 c.372G>A synonymous_variant 0.3 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.33 isoniazid
kasA 2518513 c.399C>G synonymous_variant 0.26 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.25 isoniazid
kasA 2518528 c.414C>T synonymous_variant 0.26 isoniazid
kasA 2518531 c.417G>C synonymous_variant 0.28 isoniazid
kasA 2518537 c.423C>G synonymous_variant 0.28 isoniazid
kasA 2518560 c.447_449delTGC disruptive_inframe_deletion 0.25 isoniazid
kasA 2518565 p.Ala151Ser missense_variant 0.25 isoniazid
kasA 2518572 p.Val153Ala missense_variant 0.26 isoniazid
kasA 2518574 c.460_461insCCG disruptive_inframe_insertion 0.28 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.26 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.32 isoniazid
kasA 2518610 p.Thr166Ala missense_variant 0.44 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.4 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.4 isoniazid
kasA 2518630 c.516G>A synonymous_variant 0.43 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.44 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.46 isoniazid
kasA 2518654 c.540C>T synonymous_variant 0.44 isoniazid
kasA 2518663 c.549T>G synonymous_variant 0.43 isoniazid
kasA 2518670 c.556_558delGTGinsAC frameshift_variant&missense_variant 0.42 isoniazid
kasA 2518673 p.Met187Leu missense_variant 0.42 isoniazid
kasA 2518688 p.Val192Ile missense_variant 0.48 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.47 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.45 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.45 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.31 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.3 isoniazid
kasA 2518786 c.672G>A synonymous_variant 0.31 isoniazid
kasA 2518787 c.673_675delCGGinsGC frameshift_variant&missense_variant 0.29 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.29 isoniazid
kasA 2518798 c.684G>A synonymous_variant 0.29 isoniazid
kasA 2518816 c.702C>G synonymous_variant 0.32 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.3 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.3 isoniazid
kasA 2518828 c.714G>C synonymous_variant 0.3 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.3 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.3 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.29 isoniazid
kasA 2518849 c.735G>C synonymous_variant 0.24 isoniazid
kasA 2518853 p.Leu247Val missense_variant 0.26 isoniazid
kasA 2518861 c.747G>A synonymous_variant 0.28 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.26 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.22 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.24 isoniazid
kasA 2519194 c.1080G>C synonymous_variant 0.24 isoniazid
kasA 2519197 c.1083G>C synonymous_variant 0.26 isoniazid
kasA 2519203 c.1089C>G synonymous_variant 0.31 isoniazid
kasA 2519212 c.1098C>T synonymous_variant 0.33 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.33 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.33 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.35 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 0.33 isoniazid
kasA 2519264 p.Val384Ile missense_variant 0.35 isoniazid
kasA 2519269 c.1155C>G synonymous_variant 0.38 isoniazid
kasA 2519275 c.1161C>A synonymous_variant 0.38 isoniazid
kasA 2519281 c.1167G>C synonymous_variant 0.38 isoniazid
kasA 2519287 c.1173T>C synonymous_variant 0.38 isoniazid
kasA 2519291 c.1177_1179delGATinsAC frameshift_variant&missense_variant 0.37 isoniazid
kasA 2519298 p.Arg395Gln missense_variant 0.31 isoniazid
kasA 2519305 c.1191A>G synonymous_variant 0.31 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.31 isoniazid
kasA 2519323 c.1209G>C synonymous_variant 0.28 isoniazid
kasA 2519332 c.1218C>G synonymous_variant 0.25 isoniazid
ahpC 2726252 c.60C>T synonymous_variant 0.27 isoniazid
ahpC 2726258 c.66C>T synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ahpC 2726264 c.72C>G synonymous_variant 0.44 isoniazid
ahpC 2726303 c.111T>C synonymous_variant 0.57 isoniazid
ahpC 2726307 p.Thr39Ser missense_variant 0.5 isoniazid
ahpC 2726312 c.120T>C synonymous_variant 0.52 isoniazid
ahpC 2726318 p.Glu42Asp missense_variant 0.52 isoniazid
ahpC 2726319 c.127_129delCACinsTT frameshift_variant&missense_variant 0.52 isoniazid Uncertain significance
ahpC 2726324 c.132A>G synonymous_variant 0.52 isoniazid Not assoc w R - Interim
Rv2477c 2782396 c.1647G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782399 c.1644T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782408 c.1635T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782414 p.Asp543Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782419 p.Val542Ile missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782420 c.1623T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782432 c.1609_1611delGTGinsAC frameshift_variant&missense_variant 0.28 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782435 c.1608G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782441 c.1602G>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782496 p.Asp516Ala missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.45 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782504 c.1539G>A synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782579 c.1464C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782597 c.1446G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782656 c.1387C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782669 c.1374A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782675 c.1368G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782690 c.1353C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783122 c.921G>A synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783143 c.900G>A synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.47 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783152 c.891G>A synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783167 c.876G>A synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783181 c.862C>T synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>A synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783206 c.837G>C synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783239 c.804G>A synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783251 c.792G>A synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783347 c.696C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783401 c.642C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783407 c.636C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783415 c.628C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783434 c.609C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783476 c.567C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783505 c.538C>T synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783516 c.526_527delTCinsAG synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159Tyr missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 c.465G>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783584 c.457_459delGCCinsCT frameshift_variant&synonymous_variant 0.33 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783605 c.438T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783623 c.420G>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783653 c.390C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783673 c.370C>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783708 p.Thr112Ser missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783722 c.321C>T synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783746 c.297G>A synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783757 p.Ile96Leu missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783788 c.255T>A synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783806 c.237G>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783826 c.217C>T synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783866 c.177C>T synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783917 c.126C>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783923 c.120C>T synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783929 c.114C>A synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783950 c.93C>A synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 p.Tyr29Leu missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 p.Ser27Asn missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784017 p.Lys9Arg missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064899 c.1293G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064908 c.1284C>T synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064932 c.1260T>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064935 c.1257A>G synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064941 c.1251A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3064947 c.1245A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064950 c.1242C>G synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064968 p.Lys408Ala missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065004 c.1186_1188delGTGinsAC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065013 c.1179G>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065016 c.1176C>T synonymous_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065058 c.1134C>G synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065061 c.1131C>T synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065073 c.1119C>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065087 c.1105A>C synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid Not assoc w R - Interim
Rv2752c 3065088 c.1104A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065094 c.1098C>T synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin