TB-Profiler result

Run: SRR6046382
Summary

Run ID: SRR6046382

Sample name:

Date: 2024-10-04T04:23:13.237483

Number of reads: 1144812

Percentage reads mapped: 37.3

Median coverage: 34.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.95
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.96
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
La1.7.X-unk4 M.bovis None 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 927 c.927G>A synonymous_variant 0.26 isoniazid
dnaA 933 c.933C>T synonymous_variant 0.26 isoniazid
dnaA 942 c.942C>T synonymous_variant 0.32 isoniazid
dnaA 948 c.948C>T synonymous_variant 0.33 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.35 isoniazid
dnaA 963 c.963C>T synonymous_variant 0.4 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.4 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.39 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 987 c.987C>T synonymous_variant 0.39 isoniazid
dnaA 990 c.990A>C synonymous_variant 0.4 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.48 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.49 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.47 isoniazid
dnaA 1020 c.1020C>G synonymous_variant 0.47 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.49 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.49 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.53 isoniazid
dnaA 1056 c.1056G>C synonymous_variant 0.52 isoniazid Not assoc w R - Interim
dnaA 1059 c.1059C>A synonymous_variant 0.51 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.46 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.42 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.43 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.3 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.3 isoniazid
gyrB 6121 c.882C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6145 c.906C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrB 6184 c.945C>T synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6190 c.951A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6202 c.963C>T synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6203 p.Ser322Ala missense_variant 0.43 levofloxacin
moxifloxacin
gyrB 6211 c.972G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6220 c.981G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6235 c.996C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6244 c.1005C>A synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6247 c.1008G>A synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.49 levofloxacin
moxifloxacin
gyrB 6358 c.1119C>G synonymous_variant 0.49 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940_-938delTTGinsCTC upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6367 c.-935C>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>A upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6571 c.-731T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6583 c.-719G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6592 c.-710C>A upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6595 c.1356G>A synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6610 c.-692C>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6628 c.-674C>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6646 c.-656C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6664 c.1425C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6766 c.-536G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.55 levofloxacin
moxifloxacin
gyrB 6805 c.1566G>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6850 c.-452C>T upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6866 c.-436C>T upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6991 c.-311C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6997 c.-305G>A upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7027 c.-275G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 7057 c.1818C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7060 c.1821T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7075 c.-227T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7076 c.-226_-224delCTAinsTTG upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7114 c.-188C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>T upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7136 c.-166_-164delTTGinsCTA upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>A upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7171 c.-131C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 7178 c.-124_-122delTTGinsCTC upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7192 c.-110G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7219 c.-83C>A upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7418 c.117C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7448 c.147G>A synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7490 c.189C>A synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7568 c.267C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7607 c.306C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7614 p.Leu105Met missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7619 c.318C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7775 c.474C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7796 c.495G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7797 c.496_498delCTAinsTTG synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7811 c.510C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7814 c.513C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7832 c.531G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8253 p.Ile318Leu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8258 c.957G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8345 c.1044C>T synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8360 c.1059G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8369 c.1068G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8405 c.1104C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8433 p.Thr378Arg missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8534 c.1233G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8556 p.Ala419Gln missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8580 p.Ile427Val missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8588 c.1287G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8706 c.1405C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8791 c.1491G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8837 c.1536C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8927 c.1626G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8933 c.1632G>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8975 c.1674C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.41 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9016 p.Thr572Ser missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9056 c.1755C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9063 p.Ser588Ala missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9086 c.1785C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9089 c.1788G>A synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9113 c.1812C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9139 p.Gln613Arg missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.35 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9174 c.1873C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9192 c.1891C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9208 p.Lys636Arg missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9212 c.1911G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9218 p.Asp639Glu missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9245 c.1944C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9267 p.Asn656Gly missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9332 c.2031C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.36 levofloxacin
moxifloxacin
fgd1 491202 c.420G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491223 c.441C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491226 c.444C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491249 p.Arg156His missense_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491262 c.480C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491277 c.495G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491283 p.Asp167Glu missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.28 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491295 c.513C>G synonymous_variant 0.29 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491302 p.Ile174Val missense_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491310 c.528C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491331 c.549G>A synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491340 c.558C>A synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491343 c.561C>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491349 c.567T>C synonymous_variant 0.26 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491472 c.690A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491496 c.714C>T synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491499 c.717G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491509 c.727T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 491556 c.774G>A synonymous_variant 0.41 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491559 c.777G>A synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491595 c.813C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491640 c.858G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491643 c.861G>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491649 c.867C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575561 p.Met72Val missense_variant 0.25 isoniazid
ethionamide
mshA 575571 p.Ser75Thr missense_variant 0.25 isoniazid
ethionamide
mshA 575581 c.234C>T synonymous_variant 0.24 isoniazid
ethionamide
mshA 575582 c.235C>T synonymous_variant 0.24 isoniazid
ethionamide
mshA 575590 c.243T>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575593 c.246G>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575596 c.249C>G synonymous_variant 0.29 isoniazid
ethionamide
mshA 575597 p.Ile84Val missense_variant 0.29 isoniazid
ethionamide
mshA 575626 c.279C>G synonymous_variant 0.39 isoniazid
ethionamide
mshA 575629 c.282A>G synonymous_variant 0.41 isoniazid
ethionamide
mshA 575633 p.Ala96Thr missense_variant 0.38 isoniazid
ethionamide
mshA 575645 p.Val100Thr missense_variant 0.36 isoniazid
ethionamide
mshA 575652 p.Arg102Gln missense_variant 0.41 isoniazid
ethionamide
mshA 575656 c.309G>C synonymous_variant 0.42 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.44 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.45 isoniazid
ethionamide
mshA 575689 c.342G>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575692 c.345G>T synonymous_variant 0.28 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ethionamide
mshA 575701 c.354G>A synonymous_variant 0.26 isoniazid
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575705 c.358_360delTTGinsCTC synonymous_variant 0.28 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.3 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.4 isoniazid
ethionamide
mshA 575752 c.405G>A synonymous_variant 0.35 isoniazid Not assoc w R - Interim
ethionamide
mshA 575756 c.409C>T synonymous_variant 0.35 isoniazid
ethionamide
mshA 575788 c.441C>T synonymous_variant 0.33 isoniazid
ethionamide
mshA 575816 c.469C>T synonymous_variant 0.34 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575830 c.483C>A synonymous_variant 0.37 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.36 isoniazid
ethionamide
mshA 575845 c.498C>G synonymous_variant 0.38 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.37 isoniazid
ethionamide
mshA 575869 c.522G>A synonymous_variant 0.37 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.88 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620361 c.471C>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620619 c.729G>T synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620631 c.741T>C synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620634 c.744C>G synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620647 p.Glu253Gln missense_variant 0.37 kanamycin
capreomycin
amikacin
ccsA 620676 c.786C>T synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620685 c.795G>A synonymous_variant 0.41 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620697 c.807C>T synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620712 c.822G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.52 kanamycin
capreomycin
amikacin
ccsA 620754 c.864G>C synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620760 c.870C>G synonymous_variant 0.54 kanamycin
capreomycin
amikacin
ccsA 620766 c.876C>G synonymous_variant 0.5 kanamycin
capreomycin
amikacin
Rv0565c 656129 p.Tyr448His missense_variant 0.22 ethionamide
Rv0565c 656131 p.Pro447Leu missense_variant 0.22 ethionamide
Rv0565c 656136 c.1335G>C synonymous_variant 0.22 ethionamide
Rv0565c 656140 p.Lys444Leu missense_variant 0.21 ethionamide
Rv0565c 656145 c.1326T>C synonymous_variant 0.2 ethionamide
Rv0565c 656157 c.1314T>C synonymous_variant 0.2 ethionamide
Rv0565c 656495 p.Ala326Thr missense_variant 0.26 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
Rv0565c 656514 c.957C>T synonymous_variant 0.26 ethionamide
Rv0565c 656526 c.945G>A synonymous_variant 0.29 ethionamide
Rv0565c 656535 c.936C>A synonymous_variant 0.37 ethionamide
Rv0565c 656538 p.Ser311Glu missense_variant 0.31 ethionamide
Rv0565c 656542 p.Thr310Ser missense_variant 0.32 ethionamide
Rv0565c 656547 c.924C>G synonymous_variant 0.32 ethionamide
Rv0565c 656551 p.Asn307Val missense_variant 0.32 ethionamide
Rv0565c 656556 c.915G>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
Rv0565c 656582 c.889C>T synonymous_variant 0.38 ethionamide
Rv0565c 656583 c.888A>G synonymous_variant 0.38 ethionamide
Rv0565c 656589 c.882T>C synonymous_variant 0.38 ethionamide
Rv0565c 656611 p.Thr287Lys missense_variant 0.32 ethionamide
Rv0565c 656616 c.855C>T synonymous_variant 0.32 ethionamide
Rv0565c 656622 p.Glu283Asp missense_variant 0.23 ethionamide
Rv0565c 656627 p.Ile282Val missense_variant 0.23 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.94 ethionamide Uncertain significance
Rv0565c 657596 c.-126G>C upstream_gene_variant 0.34 ethionamide
Rv0565c 657602 c.-132C>A upstream_gene_variant 0.38 ethionamide
Rv0565c 657608 c.-138C>G upstream_gene_variant 0.37 ethionamide
Rv0565c 657626 c.-158_-156delCGCinsAAG upstream_gene_variant 0.39 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.37 ethionamide
Rv0565c 657640 c.-170A>T upstream_gene_variant 0.35 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.35 ethionamide
Rv0565c 657647 c.-177C>G upstream_gene_variant 0.38 ethionamide
Rv0565c 657659 c.-189G>A upstream_gene_variant 0.38 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.39 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.41 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.29 ethionamide
nusG 734439 c.186C>G synonymous_variant 0.25 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.25 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.26 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.26 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.27 rifampicin
nusG 734463 c.210G>A synonymous_variant 0.27 rifampicin
nusG 734466 c.213G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.29 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>A synonymous_variant 0.38 rifampicin
nusG 734514 c.261A>G synonymous_variant 0.34 rifampicin
nusG 734517 c.264G>A synonymous_variant 0.37 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.4 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.47 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.47 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760136 c.330G>A synonymous_variant 0.43 rifampicin
rpoB 760139 c.333A>C synonymous_variant 0.43 rifampicin
rpoB 760174 p.Tyr123Phe missense_variant 0.49 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.51 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.58 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.5 rifampicin
rpoB 760307 c.501T>G synonymous_variant 0.53 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.54 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.55 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.55 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.49 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.47 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760436 c.630C>G synonymous_variant 0.51 rifampicin
rpoB 760451 c.645C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760493 c.687C>T synonymous_variant 0.49 rifampicin
rpoB 760497 c.691C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.4 rifampicin Uncertain significance
rpoB 760526 c.720G>A synonymous_variant 0.41 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.4 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.39 rifampicin Uncertain significance
rpoB 760597 p.Thr264Ser missense_variant 0.36 rifampicin
rpoB 760604 p.Glu266Asp missense_variant 0.33 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760643 c.837G>A synonymous_variant 0.35 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760844 p.Gln346His missense_variant 0.44 rifampicin
rpoB 760845 p.Thr347Ala missense_variant 0.44 rifampicin
rpoB 760855 p.Thr350Lys missense_variant 0.42 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.44 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.48 rifampicin
rpoB 760916 c.1110C>G synonymous_variant 0.51 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.53 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.54 rifampicin
rpoB 760971 c.1165C>A synonymous_variant 0.51 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.53 rifampicin
rpoB 761006 c.1200C>T synonymous_variant 0.53 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.42 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.42 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.43 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.43 rifampicin
rpoB 761147 c.1341C>G synonymous_variant 0.41 rifampicin
rpoB 761150 c.1344A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.41 rifampicin
rpoB 761162 c.1356G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.39 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.34 rifampicin
rpoB 761183 c.1377T>C synonymous_variant 0.38 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.4 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.41 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.4 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761274 c.1468C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761314 p.Phe503Tyr missense_variant 0.39 rifampicin
rpoB 761324 c.1518C>T synonymous_variant 0.43 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761349 p.Asp515Asn missense_variant 0.36 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.4 rifampicin
rpoB 761405 c.1599C>T synonymous_variant 0.36 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.36 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.33 rifampicin
rpoB 761437 p.Ala544Glu missense_variant 0.35 rifampicin
rpoB 761441 c.1635C>T synonymous_variant 0.35 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.35 rifampicin
rpoB 761451 p.Val549Thr missense_variant 0.33 rifampicin
rpoB 761462 c.1656C>G synonymous_variant 0.35 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.31 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.25 rifampicin
rpoB 761486 c.1680C>G synonymous_variant 0.29 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.28 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.32 rifampicin
rpoB 761507 c.1701G>C synonymous_variant 0.29 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.35 rifampicin
rpoB 761603 c.1797C>G synonymous_variant 0.35 rifampicin
rpoB 761604 c.1798_1800delCTCinsTTG synonymous_variant 0.34 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.37 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761640 c.1834C>T synonymous_variant 0.36 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>A synonymous_variant 0.31 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.23 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.29 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.33 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.34 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.36 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.37 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>G synonymous_variant 0.38 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.39 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.39 rifampicin
rpoB 761885 c.2079T>G synonymous_variant 0.42 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.45 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.44 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.43 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.46 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.45 rifampicin
rpoB 761916 p.Asp704His missense_variant 0.45 rifampicin
rpoB 761945 c.2139G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.53 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761997 p.Leu731Ile missense_variant 0.46 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.51 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Ile missense_variant 0.46 rifampicin
rpoB 762050 c.2244G>A synonymous_variant 0.45 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762110 c.2304G>C synonymous_variant 0.46 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.46 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.44 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.41 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.41 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762192 c.2386C>T synonymous_variant 0.37 rifampicin
rpoB 762218 c.2412T>G synonymous_variant 0.38 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.37 rifampicin
rpoB 762257 c.2451C>A synonymous_variant 0.34 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.35 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762297 c.2491C>T synonymous_variant 0.35 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.4 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.44 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.42 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.4 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.35 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.28 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.28 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.27 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.25 rifampicin
rpoC 762482 c.-888C>T upstream_gene_variant 0.27 rifampicin
rpoB 762491 c.2685T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.31 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.31 rifampicin Uncertain significance
rpoC 762533 c.-837T>C upstream_gene_variant 0.4 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.4 rifampicin
rpoC 762537 c.-833_-831delTTGinsCTC upstream_gene_variant 0.4 rifampicin
rpoC 762542 c.-828C>T upstream_gene_variant 0.4 rifampicin
rpoB 762548 c.2742C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762551 c.-819C>G upstream_gene_variant 0.42 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.41 rifampicin
rpoC 762605 c.-765T>C upstream_gene_variant 0.31 rifampicin
rpoB 762624 p.Val940Ile missense_variant 0.23 rifampicin
rpoB 762630 p.Ala942Thr missense_variant 0.21 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.37 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762814 p.Met1003Thr missense_variant 0.38 rifampicin Uncertain significance
rpoB 762818 c.3012C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.46 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.5 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.53 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.51 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.47 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.44 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.21 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.35 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.38 rifampicin Uncertain significance
rpoC 763441 c.72C>G synonymous_variant 0.42 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763489 c.120G>A synonymous_variant 0.52 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763552 c.183C>T synonymous_variant 0.59 rifampicin Not assoc w R
rpoC 763561 c.192G>A synonymous_variant 0.61 rifampicin
rpoC 763570 c.201G>T synonymous_variant 0.62 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>A synonymous_variant 0.54 rifampicin
rpoC 763609 c.240C>G synonymous_variant 0.52 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.52 rifampicin
rpoC 763654 c.285C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.39 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.39 rifampicin
rpoC 763726 c.357C>T synonymous_variant 0.39 rifampicin
rpoC 763727 c.358C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.38 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.38 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.38 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.35 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.35 rifampicin
rpoC 763781 p.Ser138Asp missense_variant 0.37 rifampicin
rpoC 763796 p.Met143Leu missense_variant 0.39 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.45 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763831 c.462A>G synonymous_variant 0.28 rifampicin
rpoC 763903 c.534G>A synonymous_variant 0.25 rifampicin
rpoC 763916 p.Glu183Gln missense_variant 0.25 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.32 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.49 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.5 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.51 rifampicin
rpoC 764027 p.Glu220Gln missense_variant 0.52 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.49 rifampicin
rpoC 764039 p.Ser224Asp missense_variant 0.47 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.49 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.5 rifampicin
rpoC 764068 c.699G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764071 c.702G>C synonymous_variant 0.44 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.49 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.49 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.48 rifampicin Uncertain significance
rpoC 764161 c.792G>C synonymous_variant 0.49 rifampicin
rpoC 764195 p.Ser276Ala missense_variant 0.55 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.55 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.54 rifampicin
rpoC 764209 c.840C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>T synonymous_variant 0.54 rifampicin
rpoC 764255 c.886C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764269 c.900G>T synonymous_variant 0.49 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764285 p.Gly306Ser missense_variant 0.43 rifampicin
rpoC 764317 c.948C>A synonymous_variant 0.33 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.31 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.27 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.39 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.46 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.43 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764570 c.1203_1204delGC frameshift_variant 0.39 rifampicin
rpoC 764577 c.1208_1209delCCinsGAGT frameshift_variant&stop_gained 0.36 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.38 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.39 rifampicin
rpoC 764680 c.1311G>A synonymous_variant 0.36 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.4 rifampicin
rpoC 764713 c.1344G>A synonymous_variant 0.45 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.49 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764770 c.1401G>A synonymous_variant 0.49 rifampicin
rpoC 764782 c.1413C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764812 c.1443C>G synonymous_variant 0.53 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764861 c.1492C>T synonymous_variant 0.54 rifampicin
rpoC 764875 c.1506C>G synonymous_variant 0.52 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.48 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.46 rifampicin
rpoC 764918 p.Val517Ile missense_variant 0.41 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.43 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764986 c.1617C>T synonymous_variant 0.4 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.38 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.36 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.33 rifampicin
rpoC 765076 c.1707A>G synonymous_variant 0.37 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765122 c.1753C>T synonymous_variant 0.29 rifampicin
rpoC 765145 c.1776C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765361 c.1992C>G synonymous_variant 0.18 rifampicin
rpoC 765391 c.2022C>T synonymous_variant 0.38 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.39 rifampicin
rpoC 765404 p.Leu679Met missense_variant 0.37 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.33 rifampicin
rpoC 765415 c.2046G>C synonymous_variant 0.33 rifampicin
rpoC 765452 p.Ala695Thr missense_variant 0.43 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765544 c.2175C>G synonymous_variant 0.53 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.54 rifampicin
rpoC 765548 c.2179_2180delAGinsTC synonymous_variant 0.56 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765590 p.Arg741Asn missense_variant 0.65 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.65 rifampicin
rpoC 765611 p.His748Ala missense_variant 0.61 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765655 c.2286T>A synonymous_variant 0.57 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.51 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.52 rifampicin
rpoC 765781 p.Asp804Glu missense_variant 0.53 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.52 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.52 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.48 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.48 rifampicin
rpoC 765826 c.2457T>G synonymous_variant 0.46 rifampicin
rpoC 765835 c.2466C>A synonymous_variant 0.45 rifampicin
rpoC 765836 c.2467C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765865 c.2496C>T synonymous_variant 0.41 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 0.4 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.39 rifampicin Uncertain significance
rpoC 765883 c.2514C>G synonymous_variant 0.36 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.35 rifampicin
rpoC 765908 c.2539C>T synonymous_variant 0.3 rifampicin
rpoC 765937 c.2568T>G synonymous_variant 0.2 rifampicin
rpoC 765940 c.2571A>G synonymous_variant 0.2 rifampicin
rpoC 765943 c.2574G>A synonymous_variant 0.2 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.19 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766194 p.Gln942Arg missense_variant 0.23 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.22 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.29 rifampicin
rpoC 766402 c.3033C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.36 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.4 rifampicin
rpoC 766442 p.Thr1025Val missense_variant 0.39 rifampicin
rpoC 766445 p.Gly1026Ser missense_variant 0.38 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.45 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.47 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.51 rifampicin
rpoC 766518 p.Thr1050Ser missense_variant 0.53 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.55 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.52 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.54 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.52 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.54 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.55 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.63 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.63 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.56 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.63 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.67 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.69 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 0.34 rifampicin Not assoc w R
rpoC 766651 c.3282T>C synonymous_variant 0.56 rifampicin
rpoC 766652 p.Ser1095Thr missense_variant 0.56 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.56 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.57 rifampicin
rpoC 766684 c.3315C>G synonymous_variant 0.52 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.43 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.42 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.28 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.33 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.35 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766834 c.3465G>A synonymous_variant 0.42 rifampicin
rpoC 766843 c.3474T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.52 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.51 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.51 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.5 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.53 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.5 rifampicin
rpoC 766933 c.3564A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766942 c.3573C>A synonymous_variant 0.5 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.51 rifampicin
rpoC 766988 c.3619C>T synonymous_variant 0.47 rifampicin
rpoC 766996 c.3627C>G synonymous_variant 0.5 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.59 rifampicin
rpoC 767066 c.3697C>T synonymous_variant 0.62 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>A synonymous_variant 0.57 rifampicin
rpoC 767162 p.Asn1265Ala missense_variant 0.54 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.54 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767239 c.3870T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.3 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.28 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776009 c.2472A>G synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 776024 c.2457G>C synonymous_variant 0.22 bedaquiline
clofazimine
mmpL5 776030 c.2451G>A synonymous_variant 0.21 bedaquiline
clofazimine
mmpL5 776038 p.Ser815Ala missense_variant 0.22 bedaquiline
clofazimine
mmpL5 776040 p.Ala814Ser missense_variant 0.21 bedaquiline
clofazimine
mmpL5 776056 p.Val809Leu missense_variant 0.23 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 778588 p.Gln106His missense_variant 0.44 bedaquiline
clofazimine
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781622 c.63C>T synonymous_variant 0.29 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781634 c.75G>A synonymous_variant 0.32 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.33 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.3 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.29 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.29 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.34 streptomycin
rpsL 781703 c.144G>A synonymous_variant 0.39 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.42 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.43 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.42 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.41 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.41 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.42 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.42 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.42 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.43 streptomycin
rpsL 781778 c.219C>T synonymous_variant 0.4 streptomycin
rpsL 781779 c.220C>T synonymous_variant 0.42 streptomycin
rpsL 781799 c.240G>C synonymous_variant 0.41 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.49 streptomycin
rpsL 781826 c.267C>T synonymous_variant 0.46 streptomycin Not assoc w R - Interim
rpsL 781832 c.273T>C synonymous_variant 0.47 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.5 streptomycin
rpsL 781856 c.297C>G synonymous_variant 0.44 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.42 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.42 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.43 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.46 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.47 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.48 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.47 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.48 streptomycin
rplC 800574 c.-235_-233delGTCinsATG upstream_gene_variant 0.18 linezolid
rplC 800579 c.-230C>G upstream_gene_variant 0.21 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.21 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.26 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.26 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.26 linezolid
rplC 800603 c.-206G>T upstream_gene_variant 0.28 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.31 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.32 linezolid
rplC 800630 c.-179G>C upstream_gene_variant 0.26 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.26 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.29 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800657 c.-152G>A upstream_gene_variant 0.28 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.28 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.27 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.23 linezolid
rplC 800726 c.-83G>A upstream_gene_variant 0.23 linezolid
rplC 801171 c.363A>G synonymous_variant 0.2 linezolid
rplC 801174 c.366T>C synonymous_variant 0.24 linezolid
rplC 801195 c.387G>C synonymous_variant 0.28 linezolid
rplC 801201 c.393C>T synonymous_variant 0.27 linezolid
rplC 801210 c.402T>G synonymous_variant 0.24 linezolid Not assoc w R - Interim
rplC 801216 c.408C>T synonymous_variant 0.23 linezolid
rplC 801222 c.414T>C synonymous_variant 0.23 linezolid
rplC 801228 c.420T>C synonymous_variant 0.23 linezolid
rplC 801231 c.423C>T synonymous_variant 0.23 linezolid
rplC 801234 c.426G>A synonymous_variant 0.22 linezolid
rplC 801237 c.429G>C synonymous_variant 0.23 linezolid
rplC 801246 c.438C>A synonymous_variant 0.21 linezolid
rplC 801249 c.441T>C synonymous_variant 0.22 linezolid
rplC 801252 c.444G>C synonymous_variant 0.22 linezolid
rplC 801255 c.447C>T synonymous_variant 0.23 linezolid
rplC 801258 c.450C>G synonymous_variant 0.23 linezolid
rplC 801264 c.456C>G synonymous_variant 0.21 linezolid Not assoc w R - Interim
rplC 801267 c.459A>C synonymous_variant 0.21 linezolid
rplC 801270 c.462T>C synonymous_variant 0.22 linezolid
rplC 801276 c.468G>A synonymous_variant 0.24 linezolid
rplC 801282 c.474G>C synonymous_variant 0.25 linezolid
rplC 801321 c.513C>T synonymous_variant 0.19 linezolid Not assoc w R - Interim
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303464 c.534A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303470 c.540T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303476 c.546G>C synonymous_variant 0.29 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303488 c.558G>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303509 c.579G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303557 c.627G>T synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1303581 c.651G>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303890 c.960G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>A synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303929 c.999G>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303951 p.Asp341Gln missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303966 c.1036C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303974 c.1044C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304013 c.1083G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304020 p.His364Tyr missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304040 c.1110C>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304085 c.1155C>A synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304092 p.Met388Leu missense_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304099 p.Gln390Pro missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304104 c.1174C>T synonymous_variant 0.39 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304111 p.Ala394Val missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304115 c.1185A>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304127 c.1197A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304130 c.1200G>A synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304133 c.1203G>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304142 c.1212G>A synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304157 c.1227G>A synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304163 c.1233G>T synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304166 c.1236A>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304172 c.1242G>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1304173 p.Val415Thr missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304184 c.1254G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304192 p.Ala421Val missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304481 c.1551T>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304496 c.1566T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304511 c.1581C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304517 c.1587C>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304520 c.1590A>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304532 c.1602G>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304538 c.1608C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>G synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304650 p.Ala574Pro missense_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304655 c.1725C>T synonymous_variant 0.47 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304661 c.1731C>T synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304665 c.1735C>T synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304673 c.1743C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Ala missense_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304682 c.1752C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304688 p.Asp586Glu missense_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304698 p.Glu590Gln missense_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.35 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304958 c.2028T>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304970 c.2040G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305030 c.2100G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305043 c.2113_2115delTCAinsAGC synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305066 c.2136T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305078 c.2148A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1305081 c.2151G>A synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305090 c.2160C>G synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1305096 c.2166T>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305099 c.2169T>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305114 c.2184T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1305117 c.2187T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305126 c.2196T>A synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305135 c.2205C>T synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1305150 c.2220C>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1305162 c.2232C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305174 c.2244T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305177 c.2247A>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305181 c.2251T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305186 c.2256C>T synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305195 c.2265T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305204 c.2274C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305210 c.2280G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305234 c.2304G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305237 c.2307A>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305243 c.2313T>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305270 c.2340C>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1305276 c.2346G>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1305282 c.2352T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305297 c.2367G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305300 c.2370A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305303 c.2373T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305306 c.2376A>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305311 p.Arg794Gln missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305313 p.Arg795Gly missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305324 c.2394G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305331 p.Glu801Asn missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305336 c.2406T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305393 c.2463T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1305405 c.2475A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305408 c.2478G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305420 c.2490C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305421 p.Ala831Pro missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305427 c.2497C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
sigE 1364661 c.249C>G synonymous_variant 0.22 pyrazinamide
sigE 1364676 c.264C>G synonymous_variant 0.22 pyrazinamide
sigE 1364679 c.267T>C synonymous_variant 0.22 pyrazinamide
sigE 1364688 c.276C>G synonymous_variant 0.26 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.26 pyrazinamide
sigE 1364697 c.285G>A synonymous_variant 0.3 pyrazinamide
sigE 1364706 c.294G>A synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
sigE 1364709 c.297T>C synonymous_variant 0.35 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.35 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.35 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.35 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.4 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.41 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.45 pyrazinamide
sigE 1364778 c.366G>T synonymous_variant 0.42 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.42 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.41 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.44 pyrazinamide
sigE 1364805 c.393C>A synonymous_variant 0.39 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.45 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.5 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
sigE 1364898 c.486C>T synonymous_variant 0.56 pyrazinamide
sigE 1364918 p.Asp169Ala missense_variant 0.43 pyrazinamide
sigE 1364952 c.540A>C synonymous_variant 0.39 pyrazinamide
sigE 1364956 c.544C>T synonymous_variant 0.38 pyrazinamide
sigE 1364960 p.Gly183Ala missense_variant 0.38 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.32 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.32 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.32 pyrazinamide
sigE 1364994 c.582G>C synonymous_variant 0.32 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.32 pyrazinamide
sigE 1365019 c.607C>T synonymous_variant 0.32 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.26 pyrazinamide
sigE 1365037 c.625C>T synonymous_variant 0.22 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80_81delTCinsCCTTT non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471929 n.84C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476531 n.2874T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
inhA 1673946 c.-256C>G upstream_gene_variant 0.35 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1673973 c.-229G>C upstream_gene_variant 0.5 isoniazid Uncertain significance
ethionamide
inhA 1674033 c.-169T>C upstream_gene_variant 0.36 isoniazid
ethionamide
inhA 1674036 c.-166G>A upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1674037 c.-165C>A upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1674042 c.-160G>C upstream_gene_variant 0.39 isoniazid Uncertain significance
ethionamide
inhA 1674045 c.-157G>A upstream_gene_variant 0.36 isoniazid
ethionamide
inhA 1674049 c.-153C>G upstream_gene_variant 0.36 isoniazid
ethionamide
inhA 1674054 c.-148T>C upstream_gene_variant 0.36 isoniazid
ethionamide
inhA 1674060 c.-142A>G upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1674070 c.-132_-130delGTCinsATT upstream_gene_variant 0.35 isoniazid
ethionamide
inhA 1674079 c.-123C>G upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1674256 p.Ser19Ala missense_variant 0.2 isoniazid Uncertain significance
ethionamide
inhA 1674279 c.78A>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674303 c.102C>A synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674312 c.111G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674313 p.Leu38Cys missense_variant 0.22 isoniazid
ethionamide
inhA 1674321 c.120G>T synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674342 c.141T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674343 p.Gln48Glu missense_variant 0.22 isoniazid
ethionamide
inhA 1674353 p.Thr51Ile missense_variant 0.18 isoniazid
ethionamide
inhA 1674789 c.588G>A synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674790 c.589C>T synonymous_variant 0.32 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674813 c.612C>T synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674934 p.Leu245Val missense_variant 0.26 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1833559 c.18C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833560 p.Thr7Ser missense_variant 0.29 pyrazinamide
rpsA 1833568 c.27G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>C synonymous_variant 0.32 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.31 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.32 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.31 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833661 c.120A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833688 c.147C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833832 p.Glu97Asp missense_variant 0.26 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833871 c.330G>A synonymous_variant 0.27 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.29 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.33 pyrazinamide
rpsA 1833901 c.360G>A synonymous_variant 0.34 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.36 pyrazinamide
rpsA 1833916 c.375C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833922 c.381G>A synonymous_variant 0.44 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833937 c.396G>A synonymous_variant 0.48 pyrazinamide
rpsA 1833949 c.408T>A synonymous_variant 0.48 pyrazinamide
rpsA 1833952 c.411C>G synonymous_variant 0.49 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.56 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834009 c.468C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.33 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834165 c.624A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834174 c.633C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834237 c.696C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.46 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834285 c.744G>A synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.52 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834381 c.840G>A synonymous_variant 0.5 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.48 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.46 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.39 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.48 pyrazinamide
rpsA 1834528 c.987T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834532 p.Val331Ile missense_variant 0.47 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834541 p.Pro334Ala missense_variant 0.45 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.5 pyrazinamide
rpsA 1834561 c.1020C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834570 p.Asp343Glu missense_variant 0.52 pyrazinamide
rpsA 1834572 p.Ala344Val missense_variant 0.51 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 0.54 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.51 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834702 p.Gln387His missense_variant 0.57 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.58 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.52 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.48 pyrazinamide
rpsA 1834761 p.Phe407Tyr missense_variant 0.47 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.47 pyrazinamide
tsnR 1853945 p.Val114Ile missense_variant 0.39 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102827 c.216C>G synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2102836 c.207T>C synonymous_variant 0.31 isoniazid
delamanid
ethionamide
ndh 2102842 c.201A>G synonymous_variant 0.34 isoniazid
delamanid
ethionamide
ndh 2102848 c.195G>A synonymous_variant 0.35 isoniazid
delamanid
ethionamide
ndh 2102857 c.186T>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ndh 2102863 c.180C>G synonymous_variant 0.41 isoniazid
delamanid
ethionamide
ndh 2102866 c.177C>G synonymous_variant 0.42 isoniazid
delamanid
ethionamide
ndh 2102869 c.174G>T synonymous_variant 0.42 isoniazid
delamanid
ethionamide
ndh 2102872 c.171A>G synonymous_variant 0.42 isoniazid
delamanid
ethionamide
ndh 2102875 c.168C>T synonymous_variant 0.4 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2102890 c.153C>T synonymous_variant 0.44 isoniazid
delamanid
ethionamide
ndh 2102911 c.132G>C synonymous_variant 0.43 isoniazid
delamanid
ethionamide
ndh 2102929 c.114T>C synonymous_variant 0.4 isoniazid
delamanid
ethionamide
ndh 2102940 c.103C>A synonymous_variant 0.4 isoniazid
delamanid
ethionamide
ndh 2102953 c.90A>C synonymous_variant 0.4 isoniazid
delamanid
ethionamide
ndh 2102962 c.81A>C synonymous_variant 0.32 isoniazid
delamanid
ethionamide
ndh 2102965 c.78G>A synonymous_variant 0.32 isoniazid
delamanid
ethionamide
ndh 2102974 c.69G>A synonymous_variant 0.31 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155743 c.369G>C synonymous_variant 0.26 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.25 isoniazid
katG 2155755 c.357C>T synonymous_variant 0.28 isoniazid Not assoc w R - Interim
katG 2155785 c.327T>C synonymous_variant 0.4 isoniazid
katG 2155788 c.324C>T synonymous_variant 0.4 isoniazid
katG 2155794 p.Ala106Ser missense_variant 0.4 isoniazid
katG 2155806 c.306T>C synonymous_variant 0.32 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517938 c.-177C>G upstream_gene_variant 0.49 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.47 isoniazid
kasA 2517968 c.-147T>G upstream_gene_variant 0.39 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.37 isoniazid
kasA 2517983 c.-132T>C upstream_gene_variant 0.34 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.32 isoniazid
kasA 2517994 c.-121_-120delCCinsAA upstream_gene_variant 0.32 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.31 isoniazid
kasA 2518162 c.48G>C synonymous_variant 0.25 isoniazid
kasA 2518180 c.66G>A synonymous_variant 0.31 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.31 isoniazid
kasA 2518193 p.Pro27Ala missense_variant 0.31 isoniazid
kasA 2518204 c.90G>A synonymous_variant 0.36 isoniazid
kasA 2518220 c.106_108delCTGinsTTA synonymous_variant 0.34 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.35 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.34 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.33 isoniazid
kasA 2518270 c.156C>G synonymous_variant 0.33 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.29 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.29 isoniazid
kasA 2518300 c.186T>C synonymous_variant 0.26 isoniazid
kasA 2518303 c.189C>T synonymous_variant 0.3 isoniazid
kasA 2518306 c.192C>G synonymous_variant 0.3 isoniazid
kasA 2518360 c.246C>T synonymous_variant 0.29 isoniazid
kasA 2518396 c.282A>C synonymous_variant 0.28 isoniazid
kasA 2518403 p.Ser97Ala missense_variant 0.29 isoniazid
kasA 2518413 p.Ser100Thr missense_variant 0.31 isoniazid
kasA 2518429 c.315A>G synonymous_variant 0.3 isoniazid
kasA 2518439 p.Ala109Ser missense_variant 0.29 isoniazid
kasA 2518444 c.330T>G synonymous_variant 0.29 isoniazid
kasA 2518447 c.333T>C synonymous_variant 0.29 isoniazid
kasA 2518448 p.Val112Ile missense_variant 0.29 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.26 isoniazid
kasA 2518462 c.348A>G synonymous_variant 0.26 isoniazid
kasA 2518465 c.351T>C synonymous_variant 0.28 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.29 isoniazid
kasA 2518475 c.361_363delAGGinsCGA synonymous_variant 0.29 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.28 isoniazid
kasA 2518486 c.372G>A synonymous_variant 0.3 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.33 isoniazid
kasA 2518513 c.399C>G synonymous_variant 0.26 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.25 isoniazid
kasA 2518528 c.414C>T synonymous_variant 0.26 isoniazid
kasA 2518531 c.417G>C synonymous_variant 0.28 isoniazid
kasA 2518537 c.423C>G synonymous_variant 0.28 isoniazid
kasA 2518560 c.447_449delTGC disruptive_inframe_deletion 0.25 isoniazid
kasA 2518565 p.Ala151Ser missense_variant 0.25 isoniazid
kasA 2518572 p.Val153Ala missense_variant 0.26 isoniazid
kasA 2518574 c.460_461insCCG disruptive_inframe_insertion 0.28 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.26 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.32 isoniazid
kasA 2518610 p.Thr166Ala missense_variant 0.44 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.4 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.4 isoniazid
kasA 2518630 c.516G>A synonymous_variant 0.43 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.44 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.46 isoniazid
kasA 2518654 c.540C>T synonymous_variant 0.44 isoniazid
kasA 2518663 c.549T>G synonymous_variant 0.43 isoniazid
kasA 2518670 p.Val186Ile missense_variant 0.42 isoniazid
kasA 2518673 p.Met187Leu missense_variant 0.42 isoniazid
kasA 2518688 p.Val192Ile missense_variant 0.48 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.47 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.45 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.45 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.31 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.3 isoniazid
kasA 2518786 c.672G>A synonymous_variant 0.31 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.29 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.29 isoniazid
kasA 2518798 c.684G>A synonymous_variant 0.29 isoniazid
kasA 2518816 c.702C>G synonymous_variant 0.32 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.3 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.3 isoniazid
kasA 2518828 c.714G>C synonymous_variant 0.3 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.3 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.3 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.29 isoniazid
kasA 2518849 c.735G>C synonymous_variant 0.24 isoniazid
kasA 2518853 p.Leu247Val missense_variant 0.26 isoniazid
kasA 2518861 c.747G>A synonymous_variant 0.28 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.26 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.22 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.24 isoniazid
kasA 2519194 c.1080G>C synonymous_variant 0.24 isoniazid
kasA 2519197 c.1083G>C synonymous_variant 0.26 isoniazid
kasA 2519203 c.1089C>G synonymous_variant 0.31 isoniazid
kasA 2519212 c.1098C>T synonymous_variant 0.33 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.33 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.33 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.35 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 0.33 isoniazid
kasA 2519264 p.Val384Ile missense_variant 0.35 isoniazid
kasA 2519269 c.1155C>G synonymous_variant 0.38 isoniazid
kasA 2519275 c.1161C>A synonymous_variant 0.38 isoniazid
kasA 2519281 c.1167G>C synonymous_variant 0.38 isoniazid
kasA 2519287 c.1173T>C synonymous_variant 0.38 isoniazid
kasA 2519291 p.Asp393Asn missense_variant 0.37 isoniazid
kasA 2519298 p.Arg395Gln missense_variant 0.31 isoniazid
kasA 2519305 c.1191A>G synonymous_variant 0.31 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.31 isoniazid
kasA 2519323 c.1209G>C synonymous_variant 0.28 isoniazid
kasA 2519332 c.1218C>G synonymous_variant 0.25 isoniazid
ahpC 2726252 c.60C>T synonymous_variant 0.27 isoniazid
ahpC 2726258 c.66C>T synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ahpC 2726264 c.72C>G synonymous_variant 0.44 isoniazid
ahpC 2726303 c.111T>C synonymous_variant 0.57 isoniazid
ahpC 2726307 p.Thr39Ser missense_variant 0.5 isoniazid
ahpC 2726312 c.120T>C synonymous_variant 0.52 isoniazid
ahpC 2726318 p.Glu42Asp missense_variant 0.52 isoniazid
ahpC 2726319 p.His43Tyr missense_variant 0.52 isoniazid
ahpC 2726324 c.132A>G synonymous_variant 0.52 isoniazid Not assoc w R - Interim
Rv2477c 2782396 c.1647G>A synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782399 c.1644T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782408 c.1635T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782414 p.Asp543Glu missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782419 p.Val542Ile missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782420 c.1623T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782432 p.Val537Ile missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782435 c.1608G>A synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782441 c.1602G>A synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782453 c.1590C>T synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782496 p.Asp516Ala missense_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.45 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2782504 c.1539G>A synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782576 c.1467C>T synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782579 c.1464C>T synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782591 c.1452T>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782597 c.1446G>A synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782656 c.1387C>T synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782669 c.1374A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782675 c.1368G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782684 c.1359T>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782690 c.1353C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783122 c.921G>A synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783143 c.900G>A synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.47 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783152 c.891G>A synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.56 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783167 c.876G>A synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783181 c.862C>T synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.67 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>A synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783206 c.837G>C synonymous_variant 0.72 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783239 c.804G>A synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783251 c.792G>A synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783347 c.696C>T synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783377 c.666C>T synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783401 c.642C>T synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783407 c.636C>T synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783415 c.628C>T synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783434 c.609C>T synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783476 c.567C>T synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783505 c.538C>T synonymous_variant 0.39 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783516 c.526_527delTCinsAG synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783568 p.Asn159Tyr missense_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 c.465G>A synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783584 p.Ala153Pro missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783623 c.420G>A synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783653 c.390C>T synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783673 c.370C>A synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783708 p.Thr112Ser missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783722 c.321C>T synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783746 c.297G>A synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783757 p.Ile96Leu missense_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>T synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.38 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783788 c.255T>A synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783806 c.237G>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.72 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783826 c.217C>T synonymous_variant 0.67 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783866 c.177C>T synonymous_variant 0.49 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.51 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783917 c.126C>G synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783923 c.120C>T synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783929 c.114C>A synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783950 c.93C>A synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783956 p.Tyr29Leu missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783962 p.Ser27Asn missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784017 p.Lys9Arg missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3064899 c.1293G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064908 c.1284C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064932 c.1260T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064935 c.1257A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064941 c.1251A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3064947 c.1245A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064950 c.1242C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064956 p.Ser412Arg missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3064968 p.Lys408Ala missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064974 c.1218T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064998 c.1194A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065004 p.Val396Ile missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065013 c.1179G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065016 c.1176C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065055 c.1137T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065058 c.1134C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065061 c.1131C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065073 c.1119C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065087 c.1105A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin
ethambutol
Rv2752c 3065088 c.1104A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065094 c.1098C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065097 c.1095C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065106 c.1086C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065109 c.1081_1083delAGAinsCGC synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065127 c.1065G>T synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065131 p.Ala354Glu missense_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065133 c.1059T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065142 c.1050A>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065151 c.1041G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065154 c.1038G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065166 c.1026C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065169 c.1023C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065174 c.1018C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065178 c.1014G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065571 c.621G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065576 p.Ala206Ser missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065595 p.Leu199Phe missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065598 c.594G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065612 p.Thr194Ala missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065619 c.573C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065634 c.558G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065637 c.555A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065640 c.552T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065658 p.Pro178Leu missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065661 c.531A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065664 c.526_528delTTGinsCTT synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065667 c.525A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065675 p.Phe173Leu missense_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065699 p.Ile165Val missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065709 c.483C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066002 p.Met64Leu missense_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066018 c.174T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066030 c.162G>A synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066041 p.Gly51Ser missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3066042 c.150T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066118 p.Asn25Ser missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067355 c.591A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067376 c.570G>T synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087635 c.816C>T synonymous_variant 0.21 cycloserine
ald 3087641 c.822T>C synonymous_variant 0.22 cycloserine
ald 3087647 c.828A>G synonymous_variant 0.21 cycloserine
ald 3087649 p.Gly277Asp missense_variant 0.2 cycloserine
ald 3087653 c.834A>G synonymous_variant 0.2 cycloserine
ald 3087656 c.837A>G synonymous_variant 0.19 cycloserine
ald 3087710 c.891C>T synonymous_variant 0.19 cycloserine
ald 3087713 c.894G>C synonymous_variant 0.19 cycloserine
ald 3087714 p.Ala299Thr missense_variant 0.19 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624371 c.540T>G synonymous_variant 0.28 rifampicin
bedaquiline
lpqB 3624377 c.534C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624389 c.522C>G synonymous_variant 0.31 rifampicin
bedaquiline
lpqB 3624401 c.510C>T synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624407 p.Thr168Val missense_variant 0.23 rifampicin
bedaquiline
lpqB 3624422 c.489G>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624448 c.463C>T synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624449 c.462C>T synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624452 c.459T>G synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624695 c.216C>T synonymous_variant 0.41 rifampicin
bedaquiline
lpqB 3624701 c.210T>G synonymous_variant 0.41 rifampicin
bedaquiline
lpqB 3624704 c.207G>A synonymous_variant 0.45 rifampicin
bedaquiline
lpqB 3624728 c.183C>T synonymous_variant 0.42 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 0.42 rifampicin
bedaquiline
lpqB 3624776 c.135T>G synonymous_variant 0.33 rifampicin
bedaquiline
lpqB 3624783 p.Ser43Thr missense_variant 0.31 rifampicin
bedaquiline
lpqB 3624788 c.123A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624797 c.114T>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624807 p.Val35Ala missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624812 c.99T>A synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3625051 c.-141C>T upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625054 c.-144C>T upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625057 c.-147C>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625072 c.-162G>C upstream_gene_variant 0.37 rifampicin
bedaquiline
lpqB 3625075 c.-165G>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3625095 p.Glu507Lys missense_variant 0.44 rifampicin
bedaquiline
lpqB 3625102 c.-192A>G upstream_gene_variant 0.45 rifampicin
bedaquiline
lpqB 3625111 c.-201G>C upstream_gene_variant 0.42 rifampicin
bedaquiline
lpqB 3625117 c.-207T>G upstream_gene_variant 0.4 rifampicin
bedaquiline
lpqB 3625120 c.-210G>C upstream_gene_variant 0.41 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.41 rifampicin
bedaquiline
lpqB 3625129 c.-219C>T upstream_gene_variant 0.4 rifampicin
bedaquiline
lpqB 3625134 c.-224T>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3625135 c.1479A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.38 rifampicin
bedaquiline
lpqB 3625723 c.-813C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625732 c.882C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.4 rifampicin Uncertain significance
bedaquiline
lpqB 3625759 c.-849G>A upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625777 c.-867C>A upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.25 rifampicin Uncertain significance
bedaquiline Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625819 c.795G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625822 c.-912C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625825 c.-915C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625989 p.Thr209Ser missense_variant 0.2 rifampicin
bedaquiline
mtrB 3625990 c.624C>A synonymous_variant 0.2 rifampicin
bedaquiline
mtrB 3626006 p.Ser203Asn missense_variant 0.27 rifampicin
bedaquiline
mtrB 3626008 c.606G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626029 c.585A>C synonymous_variant 0.25 rifampicin
bedaquiline
mtrB 3626035 c.579G>T synonymous_variant 0.24 rifampicin
bedaquiline
mtrB 3626038 c.576C>T synonymous_variant 0.23 rifampicin
bedaquiline
mtrB 3626043 p.Ala191Thr missense_variant 0.24 rifampicin
bedaquiline
mtrB 3626054 p.Leu187Pro missense_variant 0.25 rifampicin
bedaquiline
mtrB 3626062 c.552T>C synonymous_variant 0.25 rifampicin
bedaquiline
mtrB 3626065 c.549G>C synonymous_variant 0.25 rifampicin
bedaquiline
mtrB 3626077 c.537C>G synonymous_variant 0.22 rifampicin
bedaquiline
mtrB 3626080 c.534G>A synonymous_variant 0.22 rifampicin
bedaquiline
mtrB 3626095 c.519A>G synonymous_variant 0.21 rifampicin
bedaquiline
mtrB 3626101 p.Gln171His missense_variant 0.2 rifampicin
bedaquiline
mtrB 3626104 c.510G>A synonymous_variant 0.2 rifampicin
bedaquiline
mtrB 3626107 c.507G>C synonymous_variant 0.21 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626705 c.-92G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626708 c.-95G>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3626711 p.Thr213Gln missense_variant 0.23 rifampicin
bedaquiline
mtrB 3626723 c.-110C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626735 c.-122C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626773 c.-160C>T upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>A upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrA 3626870 c.480C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626897 c.-284G>A upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626918 c.432G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3626924 c.-311G>A upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3626930 c.-317A>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrA 3626939 p.Glu137Asp missense_variant 0.4 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3626945 c.-332C>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626969 c.-356C>G upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrA 3626983 p.Asn123Tyr missense_variant 0.58 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3627002 c.-389G>T upstream_gene_variant 0.55 rifampicin
bedaquiline
mtrB 3627008 c.-395G>A upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrA 3627026 c.324G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrA 3627056 c.294C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627224 c.126G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627227 c.-614T>A upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627233 p.Thr39Ser missense_variant 0.26 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627257 c.-644C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627269 c.-656G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627272 c.-659G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627277 c.73C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627323 p.Leu9Phe missense_variant 0.19 rifampicin
bedaquiline
fbiB 3642581 c.1047A>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiB 3642593 c.1059G>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiB 3642602 c.1068A>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiB 3642611 c.1077C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3642614 c.1080C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiB 3642623 c.1089C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3642634 p.Asp367Ala missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3642656 c.1122G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiB 3642668 c.1134A>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.3 rifampicin
rpoA 3877800 c.708G>A synonymous_variant 0.32 rifampicin
rpoA 3877824 c.684G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>G synonymous_variant 0.43 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.42 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.42 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.42 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.4 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.4 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.41 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.42 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.43 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.41 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.34 rifampicin
rpoA 3878028 c.480G>T synonymous_variant 0.33 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.33 rifampicin
rpoA 3878037 c.471C>G synonymous_variant 0.34 rifampicin
rpoA 3878046 c.462T>G synonymous_variant 0.33 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.33 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.31 rifampicin
rpoA 3878064 c.444G>A synonymous_variant 0.32 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.32 rifampicin
rpoA 3878079 c.429C>G synonymous_variant 0.39 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.39 rifampicin
rpoA 3878085 c.423G>A synonymous_variant 0.36 rifampicin
rpoA 3878094 c.414C>T synonymous_variant 0.42 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.32 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.32 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.31 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.29 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.3 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>A synonymous_variant 0.27 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.35 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.55 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.6 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.58 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878403 c.105C>T synonymous_variant 0.54 rifampicin
rpoA 3878406 c.102G>C synonymous_variant 0.53 rifampicin
rpoA 3878409 c.99C>G synonymous_variant 0.54 rifampicin
rpoA 3878430 c.78G>C synonymous_variant 0.51 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.51 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.5 rifampicin
rpoA 3878451 c.57C>G synonymous_variant 0.48 rifampicin
rpoA 3878454 c.54A>T synonymous_variant 0.49 rifampicin
rpoA 3878468 p.Leu14Ile missense_variant 0.44 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.42 rifampicin
rpoA 3878475 c.33G>A synonymous_variant 0.42 rifampicin
rpoA 3878487 c.21C>A synonymous_variant 0.44 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.42 rifampicin
rpoA 3879070 c.-563G>A upstream_gene_variant 0.24 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.28 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.31 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879151 c.-644C>T upstream_gene_variant 0.41 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879181 c.-674G>A upstream_gene_variant 0.57 rifampicin
rpoA 3879190 c.-683C>A upstream_gene_variant 0.5 rifampicin
rpoA 3879197 c.-691_-690delGAinsAG upstream_gene_variant 0.48 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.53 rifampicin
rpoA 3879208 c.-701C>T upstream_gene_variant 0.56 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.32 rifampicin
rpoA 3879229 c.-722A>C upstream_gene_variant 0.32 rifampicin
ddn 3986625 c.-219A>T upstream_gene_variant 0.63 pretomanid
delamanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.56 pretomanid
delamanid
ddn 3986637 c.-207C>T upstream_gene_variant 0.56 pretomanid
delamanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.49 pretomanid
delamanid
ddn 3986656 c.-188C>G upstream_gene_variant 0.45 pretomanid
delamanid
ddn 3986665 c.-179G>A upstream_gene_variant 0.42 pretomanid
delamanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.35 pretomanid
delamanid
ddn 3986673 c.-171C>T upstream_gene_variant 0.34 pretomanid
delamanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.29 pretomanid
delamanid
ddn 3986687 c.-157C>T upstream_gene_variant 0.25 pretomanid
delamanid
clpC1 4038239 c.2466T>A synonymous_variant 0.31 pyrazinamide
clpC1 4038248 c.2457C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038254 c.2451G>A synonymous_variant 0.36 pyrazinamide
clpC1 4038266 c.2439C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038275 c.2430A>G synonymous_variant 0.41 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.46 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038338 c.2367C>T synonymous_variant 0.51 pyrazinamide
clpC1 4038354 p.Gln784Ala missense_variant 0.49 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038395 c.2310C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.42 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.52 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.55 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.58 pyrazinamide
clpC1 4038463 p.Ala748Thr missense_variant 0.57 pyrazinamide
clpC1 4038485 p.Gly740Ala missense_variant 0.48 pyrazinamide
clpC1 4038488 c.2217C>T synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4038491 c.2214C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038509 p.Asp732Glu missense_variant 0.54 pyrazinamide
clpC1 4038512 c.2193C>G synonymous_variant 0.56 pyrazinamide
clpC1 4038527 c.2178G>A synonymous_variant 0.56 pyrazinamide
clpC1 4038530 c.2175G>A synonymous_variant 0.55 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.55 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.59 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 0.57 pyrazinamide
clpC1 4038569 c.2136C>T synonymous_variant 0.58 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.51 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.49 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.53 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.52 pyrazinamide
clpC1 4038657 p.Lys683Pro missense_variant 0.45 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.45 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038683 c.2022T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038694 p.Ser671Ala missense_variant 0.51 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.53 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.57 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.42 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038920 c.1785C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038923 c.1782A>C synonymous_variant 0.36 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.37 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039001 p.Asn568Glu missense_variant 0.28 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039009 c.1696C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039031 c.1674T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039037 c.1668T>G synonymous_variant 0.33 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039145 c.1560G>T synonymous_variant 0.41 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.43 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039243 c.1462C>T synonymous_variant 0.48 pyrazinamide
clpC1 4039247 c.1458G>A synonymous_variant 0.44 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.48 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.48 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.42 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.31 pyrazinamide
clpC1 4039343 c.1362G>A synonymous_variant 0.32 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039358 p.Ser449Ala missense_variant 0.38 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.39 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039427 c.1278G>A synonymous_variant 0.37 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.44 pyrazinamide
clpC1 4039457 c.1248C>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.43 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039601 c.1104G>T synonymous_variant 0.43 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.48 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.46 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039756 c.949C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039808 c.897G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039832 c.873C>A synonymous_variant 0.34 pyrazinamide
clpC1 4039840 c.865C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039886 c.819C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039898 c.805_807delCTCinsTTG synonymous_variant 0.47 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.51 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039937 c.768G>T synonymous_variant 0.52 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.55 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.56 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.54 pyrazinamide
clpC1 4040009 p.Ala232Lys missense_variant 0.45 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040020 c.685C>T synonymous_variant 0.44 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040051 c.654C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.44 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040234 c.471C>T synonymous_variant 0.44 pyrazinamide
clpC1 4040240 c.465C>T synonymous_variant 0.45 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.45 pyrazinamide
clpC1 4040252 c.453C>T synonymous_variant 0.45 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.49 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040270 c.435C>T synonymous_variant 0.52 pyrazinamide
clpC1 4040273 c.432T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>C synonymous_variant 0.55 pyrazinamide
clpC1 4040314 c.391C>T synonymous_variant 0.56 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040333 c.372G>A synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040336 c.369G>T synonymous_variant 0.44 pyrazinamide
clpC1 4040351 c.354C>T synonymous_variant 0.41 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.47 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040465 c.240T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>G synonymous_variant 0.3 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.39 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>A synonymous_variant 0.43 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040567 c.138C>A synonymous_variant 0.44 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.45 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.48 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.49 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.43 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.5 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.48 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040681 c.24T>C synonymous_variant 0.45 pyrazinamide
clpC1 4040695 c.10C>A synonymous_variant 0.41 pyrazinamide
clpC1 4040696 c.9A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040699 c.6C>T synonymous_variant 0.41 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.4 pyrazinamide
clpC1 4040734 c.-31delT upstream_gene_variant 0.25 pyrazinamide
clpC1 4040744 c.-41delG upstream_gene_variant 0.24 pyrazinamide
clpC1 4040747 c.-43T>C upstream_gene_variant 0.23 pyrazinamide
clpC1 4040750 c.-46G>A upstream_gene_variant 0.24 pyrazinamide
clpC1 4040762 c.-58G>A upstream_gene_variant 0.18 pyrazinamide
clpC1 4040763 c.-59C>T upstream_gene_variant 0.18 pyrazinamide Uncertain significance
glpK 4138442 c.1314C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138451 c.1305T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138457 p.Asp433Glu missense_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138463 p.Gly431Ala missense_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138472 c.1284G>T synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138478 c.1278T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138490 p.Val422Leu missense_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138495 p.Gln421Glu missense_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138496 c.1260G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138502 c.1254T>G synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138511 c.1245C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138514 c.1242A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138518 p.Glu413Ala missense_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138523 c.1233C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138529 c.1227G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138538 c.1218C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138544 c.1212G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138574 c.1182G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138646 c.1110G>T synonymous_variant 0.48 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138654 c.1102C>T synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138655 c.1101G>T synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138676 c.1080T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.49 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138685 c.1071C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.46 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Thr missense_variant 0.52 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>T synonymous_variant 0.42 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138727 c.1029C>A synonymous_variant 0.42 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138747 c.1009C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138772 c.984G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240726 c.864G>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4240736 p.Ser292Ala missense_variant 0.31 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.44 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.44 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.44 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.51 ethambutol
embC 4240859 c.997C>T synonymous_variant 0.46 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.43 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.42 ethambutol
embC 4240875 p.Ser338Thr missense_variant 0.4 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.42 ethambutol
embC 4240900 c.1038A>G synonymous_variant 0.3 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.3 ethambutol
embC 4240910 p.Ala350Leu missense_variant 0.26 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.27 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.23 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.23 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.22 ethambutol
embC 4241030 c.1168C>T synonymous_variant 0.24 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.28 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.26 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.26 ethambutol
embC 4241053 c.1191G>A synonymous_variant 0.24 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.3 ethambutol
embC 4241077 c.1215C>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241080 c.1218C>T synonymous_variant 0.29 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.34 ethambutol
embC 4241101 c.1239G>C synonymous_variant 0.39 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4241125 c.1263G>C synonymous_variant 0.37 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4241158 c.1296T>C synonymous_variant 0.29 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.29 ethambutol
embC 4241168 c.1306C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241173 c.1311C>T synonymous_variant 0.31 ethambutol
embC 4241182 c.1320G>C synonymous_variant 0.31 ethambutol
embC 4241185 c.1323G>C synonymous_variant 0.31 ethambutol
embC 4241188 c.1326C>A synonymous_variant 0.3 ethambutol
embC 4241203 c.1341T>G synonymous_variant 0.32 ethambutol
embC 4241215 c.1353C>G synonymous_variant 0.31 ethambutol
embC 4241497 c.1635G>C synonymous_variant 0.24 ethambutol
embC 4241500 c.1638A>G synonymous_variant 0.25 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.3 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241528 c.1666_1668delCGCinsAGG synonymous_variant 0.3 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.26 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>G synonymous_variant 0.27 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.27 ethambutol
embC 4241560 c.1698C>G synonymous_variant 0.26 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.21 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.19 ethambutol
embC 4241591 p.Leu577Ile missense_variant 0.2 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245125 c.1893G>T synonymous_variant 0.2 ethambutol
embA 4245135 p.Tyr635Arg missense_variant 0.22 ethambutol
embA 4245189 p.Leu653Ala missense_variant 0.26 ethambutol
embA 4245198 p.Leu656Ala missense_variant 0.28 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.4 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.39 ethambutol
embA 4245234 p.Met668Leu missense_variant 0.39 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.31 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.24 ethambutol
embB 4246323 c.-191C>T upstream_gene_variant 0.23 ethambutol
embB 4246352 c.-162G>C upstream_gene_variant 0.23 ethambutol
embA 4246359 p.Ala1043Pro missense_variant 0.23 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.23 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.23 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.23 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.29 ethambutol
embB 4247395 c.882C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4247401 c.888T>C synonymous_variant 0.29 ethambutol
embB 4247404 c.891G>T synonymous_variant 0.29 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.3 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.29 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.31 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.27 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.29 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.27 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.28 ethambutol
embB 4248101 c.1588C>T synonymous_variant 0.31 ethambutol
embB 4248118 c.1605T>G synonymous_variant 0.37 ethambutol
embB 4248127 c.1614G>A synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embB 4248130 c.1617G>T synonymous_variant 0.38 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.38 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.39 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.39 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4248161 c.1648_1650delCTGinsTTA synonymous_variant 0.39 ethambutol
embB 4248166 c.1653C>T synonymous_variant 0.4 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.42 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.48 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.45 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.45 ethambutol
embB 4248205 c.1692C>T synonymous_variant 0.45 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.45 ethambutol Uncertain significance
embB 4248226 c.1713G>C synonymous_variant 0.51 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.45 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.55 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.55 ethambutol
embB 4248301 c.1788C>T synonymous_variant 0.51 ethambutol
embB 4248305 c.1792C>T synonymous_variant 0.53 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.5 ethambutol
embB 4248322 c.1809G>T synonymous_variant 0.56 ethambutol
embB 4248334 c.1821C>G synonymous_variant 0.46 ethambutol
embB 4248340 c.1827G>C synonymous_variant 0.46 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.47 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.47 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.47 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Lys missense_variant 0.46 ethambutol
embB 4248403 c.1890G>T synonymous_variant 0.33 ethambutol
embB 4248407 c.1894_1896delTTAinsCTG synonymous_variant 0.3 ethambutol
embB 4248410 p.Phe633Met missense_variant 0.3 ethambutol
embB 4248424 c.1911G>A synonymous_variant 0.34 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 0.33 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.33 ethambutol
embB 4248448 c.1935C>G synonymous_variant 0.29 ethambutol
embB 4248460 c.1947C>G synonymous_variant 0.25 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.91 ethambutol Not assoc w R
aftB 4268994 c.-158T>C upstream_gene_variant 0.21 ethambutol
ubiA 4269006 p.Asp276Glu missense_variant 0.25 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.26 ethambutol
ubiA 4269015 c.819G>A synonymous_variant 0.3 ethambutol Not assoc w R - Interim
aftB 4269027 c.-191C>G upstream_gene_variant 0.37 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.38 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.39 ethambutol
aftB 4269048 c.-212C>T upstream_gene_variant 0.43 ethambutol
ubiA 4269051 c.783C>T synonymous_variant 0.45 ethambutol Not assoc w R - Interim
ubiA 4269075 p.Ile253Val missense_variant 0.55 ethambutol
ubiA 4269088 p.Ala249Val missense_variant 0.57 ethambutol Uncertain significance
ubiA 4269090 c.744C>T synonymous_variant 0.57 ethambutol Not assoc w R - Interim
aftB 4269096 c.-260C>A upstream_gene_variant 0.6 ethambutol
ubiA 4269103 p.Ser244Ala missense_variant 0.58 ethambutol
aftB 4269114 c.-278C>T upstream_gene_variant 0.61 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.61 ethambutol
ubiA 4269143 p.Leu231Val missense_variant 0.6 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.6 ethambutol Not assoc w R - Interim
ubiA 4269164 p.Leu224Met missense_variant 0.59 ethambutol
aftB 4269171 c.-335C>G upstream_gene_variant 0.58 ethambutol
ubiA 4269199 p.Ser212Thr missense_variant 0.53 ethambutol
aftB 4269210 c.-374G>A upstream_gene_variant 0.53 ethambutol
ubiA 4269219 p.Ala205Asn missense_variant 0.5 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
aftB 4269234 c.-398A>G upstream_gene_variant 0.47 ethambutol
ubiA 4269243 p.His197Val missense_variant 0.42 ethambutol
aftB 4269270 c.-434G>C upstream_gene_variant 0.3 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R