TB-Profiler result

Run: ERR9117721
Summary

Run ID: ERR9117721

Sample name:

Date: 2024-04-15T04:55:11.596827

Number of reads: 1762295

Percentage reads mapped: 57.38

Median coverage: 52.0

Strain: La3;lineage1.1.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.2 Indo-Oceanic RD239 0.89
lineage1.1 Indo-Oceanic RD239 0.87
La1.2.BCG M.bovis None 0.16
lineage6.2.3 West-Africa 2 RD702 0.09
La3 M.orygis None 0.1
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin tlyA c.172_174delAGTinsGC Assoc w R
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.39 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.31 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.47 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.27 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethionamide Assoc w R Alias fabG1_c.-15C>T
tlyA 1918111 c.172_174delAGTinsGC frameshift_variant&missense_variant 0.22 capreomycin Assoc w R
embB 4247448 p.His312Arg missense_variant 0.25 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.29 isoniazid
dnaA 33 c.33A>G synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 42 c.42C>T synonymous_variant 0.24 isoniazid
dnaA 51 c.51C>T synonymous_variant 0.19 isoniazid
dnaA 510 c.510T>C synonymous_variant 0.25 isoniazid
dnaA 519 c.519C>G synonymous_variant 0.25 isoniazid Not assoc w R
dnaA 522 c.522T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 525 c.525T>C synonymous_variant 0.27 isoniazid
dnaA 534 c.534T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>C synonymous_variant 0.33 isoniazid
dnaA 561 c.561C>T synonymous_variant 0.31 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.31 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.31 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.25 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.25 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.27 isoniazid
dnaA 600 c.600T>A synonymous_variant 0.28 isoniazid
dnaA 612 c.612G>C synonymous_variant 0.22 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.26 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.26 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.23 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.25 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.25 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.2 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.2 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.21 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.21 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.22 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.23 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.22 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.23 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.23 isoniazid Uncertain significance
dnaA 813 c.813C>T synonymous_variant 0.24 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.23 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.23 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.23 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.27 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.27 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.27 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.26 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.19 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.2 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.2 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.17 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.21 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.23 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.25 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.31 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.29 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.25 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.26 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.26 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.26 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.33 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.36 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.29 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.29 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.3 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.3 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.33 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.32 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.31 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.32 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.3 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.29 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.3 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.32 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.37 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.34 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.31 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.31 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.3 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.34 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.28 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.3 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.3 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.3 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.28 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.25 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.19 isoniazid
gyrB 6112 p.Met291Ile missense_variant 0.87 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6123 p.Ala295Gly missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.43 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.4 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.35 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6883 p.Leu548Phe missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8111 c.810G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.36 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.52 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8459 c.1158G>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.34 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9125 c.1824C>T synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9607 p.Asp769Gly missense_variant 0.85 levofloxacin
moxifloxacin
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 490782 c.-1G>C upstream_gene_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490797 c.15G>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.47 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491100 c.318C>T synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491106 c.324T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491173 c.391C>A synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.37 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491535 c.753G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575695 c.348C>G synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.27 ethionamide
isoniazid
mshA 575704 c.357T>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.26 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.28 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.4 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.4 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.37 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.4 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.42 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.47 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.46 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.47 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.47 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.51 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.53 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.51 ethionamide
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.47 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.42 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.42 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.42 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.42 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.4 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575965 c.618C>G synonymous_variant 0.25 ethionamide
isoniazid Not assoc w R - Interim
ccsA 619507 c.-384A>G upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620298 c.408G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.26 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.27 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620659 c.769_771delCGCinsAG frameshift_variant&missense_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.4 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
Rv0565c 656172 c.1299A>G synonymous_variant 0.2 ethionamide
Rv0565c 656179 p.Asp431Thr missense_variant 0.2 ethionamide
Rv0565c 656192 p.Asp427Asn missense_variant 0.22 ethionamide Uncertain significance
Rv0565c 656196 p.Leu425Arg missense_variant 0.24 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.31 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.32 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.33 ethionamide Not assoc w R - Interim
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.29 ethionamide Uncertain significance
Rv0565c 656238 p.Ala411Glu missense_variant 0.27 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.28 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.3 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.32 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.3 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.29 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.28 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.28 ethionamide
Rv0565c 656448 c.1023T>C synonymous_variant 0.2 ethionamide
Rv0565c 656924 p.Ile183Val missense_variant 0.2 ethionamide
Rv0565c 656940 c.531C>T synonymous_variant 0.2 ethionamide Not assoc w R - Interim
Rv0565c 656946 c.525T>C synonymous_variant 0.2 ethionamide
Rv0565c 656952 c.519A>C synonymous_variant 0.21 ethionamide Not assoc w R - Interim
Rv0565c 656967 c.504T>C synonymous_variant 0.22 ethionamide
Rv0565c 656973 c.498A>G synonymous_variant 0.23 ethionamide
Rv0565c 656978 p.Ala165Thr missense_variant 0.2 ethionamide
Rv0565c 656983 p.Gly163His missense_variant 0.21 ethionamide
Rv0565c 656985 c.486T>C synonymous_variant 0.21 ethionamide
Rv0565c 656990 p.Lys161Glu missense_variant 0.22 ethionamide
Rv0565c 657000 p.Gly157Pro missense_variant 0.22 ethionamide
Rv0565c 657027 c.444T>C synonymous_variant 0.27 ethionamide
Rv0565c 657220 p.Ala84Val missense_variant 0.19 ethionamide
Rv0565c 657237 c.234A>G synonymous_variant 0.21 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.27 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.27 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.28 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.28 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.28 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.25 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.25 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.27 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.29 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.3 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.3 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.33 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.33 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.33 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.33 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.33 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.33 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.43 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.47 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.45 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.45 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.41 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.47 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.31 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.26 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.24 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.23 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.22 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.2 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.26 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.3 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.3 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.31 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.37 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.42 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.5 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.51 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.51 isoniazid
nusG 734078 c.-176C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
nusG 734093 c.-161A>C upstream_gene_variant 0.18 rifampicin
nusG 734116 c.-138T>C upstream_gene_variant 0.84 rifampicin Not assoc w R
nusG 734118 c.-136C>T upstream_gene_variant 0.84 rifampicin Uncertain significance
nusG 734147 c.-107T>C upstream_gene_variant 0.2 rifampicin
nusG 734173 c.-81C>G upstream_gene_variant 0.2 rifampicin
nusG 734176 c.-78_-77delGTinsTG upstream_gene_variant 0.2 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.2 rifampicin Uncertain significance
nusG 734376 c.123G>A synonymous_variant 0.21 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.29 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.31 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.29 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.37 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.39 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.41 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.46 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.23 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.22 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.25 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.23 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.25 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.24 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.21 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.22 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.21 rifampicin
rpoB 759546 c.-261A>G upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760060 p.Tyr85Leu missense_variant 0.21 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.22 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.21 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.38 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.43 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.43 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.45 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.38 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.38 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.38 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.38 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.39 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.38 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.38 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.35 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.37 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>T synonymous_variant 0.6 rifampicin Not assoc w R
rpoB 760522 p.Ser239Asn missense_variant 0.39 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.35 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.36 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.38 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.47 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.55 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.55 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.56 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.54 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.52 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.52 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.51 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.51 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.51 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.47 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.23 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.18 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.26 rifampicin
rpoB 760889 c.1083C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.4 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.44 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.5 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.55 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.51 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.46 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.41 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.5 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.49 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.6 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.58 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.54 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.38 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.32 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.32 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.29 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.25 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.25 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.26 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.26 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.26 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.25 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.26 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.36 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.34 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.43 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.55 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.5 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.46 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.47 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.4 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.31 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.31 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.33 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.32 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.36 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.37 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.34 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.35 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.4 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.38 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.37 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.37 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.43 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.39 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.4 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.43 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.5 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.51 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.53 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.5 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.51 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.53 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.51 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.49 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.5 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.51 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.49 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.54 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.55 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.52 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.49 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.48 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.41 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.37 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.38 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.37 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.39 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.35 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.36 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.42 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.44 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.53 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.48 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.41 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.32 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.33 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.27 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.28 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.28 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.3 rifampicin
rpoC 762794 c.-576C>G upstream_gene_variant 0.2 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.2 rifampicin Uncertain significance
rpoB 762810 p.Ala1002Ser missense_variant 0.18 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.51 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.6 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.44 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.52 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.47 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.38 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.32 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.3 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.3 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.3 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.21 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.2 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.38 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.4 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.4 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.55 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.61 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.53 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.52 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.5 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.52 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.44 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.44 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.34 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.26 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.31 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.31 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.31 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.27 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.27 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.7 rifampicin Not assoc w R
rpoC 763886 c.517_519delCGGinsAC frameshift_variant&missense_variant 0.69 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.29 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.29 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.3 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.33 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.34 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.34 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.38 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.42 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.42 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.38 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.42 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.45 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.45 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.47 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.47 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.48 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.37 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.36 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.38 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.36 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.37 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.38 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.39 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.55 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.54 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.54 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.56 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.51 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.5 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.52 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.49 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.41 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.38 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.4 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.41 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.41 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.41 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.55 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.45 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.41 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.36 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.3 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.32 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.27 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.27 rifampicin
rpoC 765171 p.Pro601Leu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765292 c.1923G>C synonymous_variant 0.24 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.25 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.27 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.35 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.36 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.43 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.44 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.47 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.46 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.48 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.46 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.42 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.41 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.43 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.47 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.48 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.49 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.45 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.45 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.45 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.45 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.46 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.46 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.45 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.54 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.52 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.5 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.39 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.41 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.42 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.43 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.44 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.46 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.48 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.45 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.44 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.38 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.33 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.32 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.3 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.3 rifampicin
rpoC 766185 p.Glu939Ala missense_variant 0.3 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766192 c.2823T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766193 c.2824_2826delCAAinsGG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 766204 c.2835C>T synonymous_variant 0.26 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.25 rifampicin
rpoC 766216 c.2847T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766219 p.Asp950Glu missense_variant 0.23 rifampicin
rpoC 766222 c.2853T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766231 c.2862T>G synonymous_variant 0.22 rifampicin
rpoC 766234 c.2865T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766237 c.2868T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766240 c.2871T>C synonymous_variant 0.2 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.19 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.19 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.24 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.28 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.29 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.34 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.38 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.36 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.38 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.43 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.43 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.46 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.48 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.51 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.44 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.39 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.34 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.36 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.36 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.38 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.35 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.38 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.37 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.34 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.32 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.34 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.35 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.35 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.4 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.36 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.36 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.36 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.35 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.36 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.39 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.42 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.44 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.42 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.59 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.56 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.57 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.58 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.58 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.52 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.48 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.41 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.29 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776395 p.Phe696Leu missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Uncertain significance
mmpL5 777176 p.Glu435Asp missense_variant 0.19 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.18 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.2 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.2 streptomycin Uncertain significance
rpsL 781608 c.49_51delAGTinsGC frameshift_variant&missense_variant 0.2 streptomycin Uncertain significance
rpsL 781628 c.69T>C synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.34 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.43 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.45 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.57 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.56 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.55 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.53 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.51 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.52 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.52 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.52 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.53 streptomycin
rpsL 781763 c.204C>A synonymous_variant 0.51 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.55 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.53 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.55 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.54 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.53 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.56 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.52 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.51 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.53 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.53 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.51 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.48 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.47 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.48 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800516 c.-293G>T upstream_gene_variant 0.29 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.32 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.33 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.33 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.29 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.25 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.3 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.32 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.32 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.28 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.27 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.33 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.38 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.38 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.4 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.41 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.38 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.32 linezolid
rplC 800792 c.-17G>A upstream_gene_variant 0.27 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.27 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.28 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.3 linezolid
rplC 800814 c.6A>G synonymous_variant 0.32 linezolid
rplC 800817 c.9A>T synonymous_variant 0.31 linezolid
rplC 800844 c.36T>C synonymous_variant 0.3 linezolid
rplC 800865 c.57A>G synonymous_variant 0.23 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.23 linezolid
rplC 800874 c.66A>G synonymous_variant 0.21 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.2 linezolid
rplC 800880 c.72A>G synonymous_variant 0.22 linezolid
rplC 800889 c.81C>G synonymous_variant 0.25 linezolid
rplC 800892 c.84G>C synonymous_variant 0.27 linezolid
rplC 800907 c.99C>G synonymous_variant 0.23 linezolid
rplC 800916 c.108A>G synonymous_variant 0.21 linezolid
rplC 800934 c.126C>G synonymous_variant 0.2 linezolid
rplC 800937 c.129A>G synonymous_variant 0.2 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.2 linezolid
rplC 800946 c.138T>C synonymous_variant 0.21 linezolid
rplC 800949 c.141T>C synonymous_variant 0.21 linezolid
rplC 800967 c.159C>G synonymous_variant 0.22 linezolid
rplC 800970 c.162T>C synonymous_variant 0.23 linezolid Not assoc w R - Interim
rplC 801174 c.366T>C synonymous_variant 0.21 linezolid
rplC 801195 c.387G>C synonymous_variant 0.27 linezolid
rplC 801207 c.399C>T synonymous_variant 0.24 linezolid
rplC 801246 c.438C>T synonymous_variant 0.29 linezolid
rplC 801249 c.441T>C synonymous_variant 0.32 linezolid
rplC 801255 c.447C>T synonymous_variant 0.31 linezolid
rplC 801264 c.456C>T synonymous_variant 0.29 linezolid
rplC 801267 c.459A>T synonymous_variant 0.31 linezolid
rplC 801270 c.462T>C synonymous_variant 0.33 linezolid
rplC 801276 c.468G>C synonymous_variant 0.3 linezolid
rplC 801279 c.471G>C synonymous_variant 0.29 linezolid
rplC 801282 c.474G>C synonymous_variant 0.29 linezolid
rplC 801285 c.477G>C synonymous_variant 0.31 linezolid
rplC 801300 c.492C>G synonymous_variant 0.33 linezolid
rplC 801309 c.501C>G synonymous_variant 0.33 linezolid
rplC 801312 c.504G>C synonymous_variant 0.31 linezolid
rplC 801321 c.513C>T synonymous_variant 0.34 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.36 linezolid
rplC 801339 c.531T>C synonymous_variant 0.29 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.29 linezolid
rplC 801348 c.540T>G synonymous_variant 0.29 linezolid
rplC 801357 c.549T>C synonymous_variant 0.27 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.25 linezolid
rplC 801402 c.594T>C synonymous_variant 0.25 linezolid
rplC 801405 c.597T>C synonymous_variant 0.25 linezolid
rplC 801423 c.615G>C synonymous_variant 0.27 linezolid
rplC 801426 c.618C>G synonymous_variant 0.25 linezolid
rplC 801427 p.Met207Val missense_variant 0.25 linezolid
rplC 801438 c.630T>C synonymous_variant 0.27 linezolid
rplC 801442 p.Ile212Val missense_variant 0.35 linezolid
Rv1129c 1253841 p.Trp232Gly missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.68 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305081 c.2151G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305135 c.2205C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305309 c.2379G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1460855 c.-190T>C upstream_gene_variant 0.19 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.22 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.24 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.21 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.23 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.22 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.22 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.22 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.21 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
inhA 1673602 c.-600C>T upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.21 ethionamide
isoniazid
fabG1 1673615 p.Glu59Val missense_variant 0.22 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.25 ethionamide
isoniazid
fabG1 1673637 p.Asp66Glu missense_variant 0.25 ethionamide
isoniazid
fabG1 1673641 p.Val68Ile missense_variant 0.25 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.26 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.26 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.35 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.37 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.29 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.3 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.33 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.3 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.26 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.34 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.17 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673985 c.-217C>A upstream_gene_variant 0.43 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.45 ethionamide
isoniazid
inhA 1674018 c.-184G>C upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1674021 c.-181G>C upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.43 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.38 ethionamide
isoniazid
inhA 1674042 c.-160G>C upstream_gene_variant 0.38 ethionamide
isoniazid Uncertain significance
fabG1 1674049 c.610_612delCAAinsGC frameshift_variant&missense_variant 0.39 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.37 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.39 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.31 ethionamide
isoniazid
inhA 1674280 p.Arg27Lys missense_variant 0.27 ethionamide
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.26 ethionamide
isoniazid
inhA 1674375 c.174C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674382 p.Leu61Ile missense_variant 0.26 ethionamide
isoniazid
inhA 1674387 c.186A>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.34 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.5 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.51 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.48 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674741 c.540C>T synonymous_variant 0.4 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674746 p.Tyr182Phe missense_variant 0.38 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674753 c.552G>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.39 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.47 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.52 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674864 c.663C>T synonymous_variant 0.5 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.4 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.42 ethionamide
isoniazid
rpsA 1833532 c.-10A>C upstream_gene_variant 0.21 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.38 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.36 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.45 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.47 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.43 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.49 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.5 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.34 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.45 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.32 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.32 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.32 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.3 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.29 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.23 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.23 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918036 p.Arg33Ser missense_variant 0.35 capreomycin
tlyA 1918048 p.Leu37Met missense_variant 0.36 capreomycin
tlyA 1918053 c.114G>C synonymous_variant 0.35 capreomycin
tlyA 1918056 c.117G>C synonymous_variant 0.33 capreomycin
tlyA 1918057 p.Val40Arg missense_variant 0.33 capreomycin
tlyA 1918065 c.126G>C synonymous_variant 0.27 capreomycin
tlyA 1918067 p.Ala43Gly missense_variant 0.24 capreomycin
tlyA 1918077 c.138G>C synonymous_variant 0.23 capreomycin
tlyA 1918078 p.Ser47Ala missense_variant 0.23 capreomycin
tlyA 1918082 p.Asp48Val missense_variant 0.23 capreomycin
tlyA 1918087 p.Thr50Ala missense_variant 0.23 capreomycin
tlyA 1918092 c.153G>C synonymous_variant 0.21 capreomycin
tlyA 1918103 p.Val55Ala missense_variant 0.24 capreomycin
tlyA 1918121 p.Ala61Gly missense_variant 0.22 capreomycin
tlyA 1918137 c.198A>C synonymous_variant 0.21 capreomycin
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063229 c.1500G>A synonymous_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063265 p.Gly488Asp missense_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063271 c.1458G>T synonymous_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063313 c.1416T>C synonymous_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101804 c.1239T>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101808 p.Thr412Ser missense_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101830 p.Ile405Val missense_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101837 p.Ala402Val missense_variant 0.28 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2101872 p.Ile391Phe missense_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101873 c.1168_1170delTTTinsCG frameshift_variant&missense_variant 0.23 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101885 c.1158G>A synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101888 c.1155T>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101891 c.1152C>G synonymous_variant 0.23 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101894 c.1149T>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101912 c.1131G>C synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2101920 c.1123A>C synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2101951 c.1092C>T synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.23 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Asp missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101993 c.1050A>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102014 c.1029C>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>A synonymous_variant 0.2 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155695 c.417C>G synonymous_variant 0.22 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.21 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.21 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.21 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.22 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.23 isoniazid
katG 2155746 c.366C>T synonymous_variant 0.24 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289987 c.-746C>T upstream_gene_variant 0.3 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.29 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.28 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.28 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.3 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.26 pyrazinamide
pncA 2290024 c.-783C>G upstream_gene_variant 0.27 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCC upstream_gene_variant 0.25 pyrazinamide
pncA 2290033 c.-792C>G upstream_gene_variant 0.23 pyrazinamide
pncA 2290038 c.-797G>A upstream_gene_variant 0.22 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.22 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.41 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.32 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.31 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518439 p.Ala109Ser missense_variant 0.18 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.2 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.2 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.21 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.23 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.24 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.24 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.32 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.33 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.39 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.42 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.4 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.38 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.34 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.35 isoniazid
kasA 2518573 c.459G>C synonymous_variant 0.35 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.37 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.4 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.38 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.39 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.36 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.31 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.29 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.22 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.27 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.32 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.38 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.37 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.41 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.48 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.47 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.49 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.45 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.42 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.61 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.58 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.54 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.54 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.5 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.51 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.5 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.4 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.41 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.42 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.4 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.34 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.34 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.29 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.25 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.25 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.24 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.24 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.23 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.23 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.31 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.31 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.33 isoniazid
kasA 2519095 c.981C>A synonymous_variant 0.35 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.33 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.33 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.35 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.36 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.31 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.33 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.36 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.37 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.96 isoniazid
ahpC 2726303 c.111T>C synonymous_variant 0.4 isoniazid
ahpC 2726311 p.Ser40Asn missense_variant 0.42 isoniazid
ahpC 2726315 p.Asp41Glu missense_variant 0.47 isoniazid
ahpC 2726318 p.Glu42Asp missense_variant 0.47 isoniazid
ahpC 2726322 c.130_132delCCAinsGC frameshift_variant&missense_variant 0.49 isoniazid Uncertain significance
ahpC 2726330 c.138G>A synonymous_variant 0.49 isoniazid Not assoc w R - Interim
ahpC 2726336 c.144G>C synonymous_variant 0.49 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.49 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.47 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.32 isoniazid
ahpC 2726378 c.186T>G synonymous_variant 0.3 isoniazid
ahpC 2726387 c.195C>T synonymous_variant 0.24 isoniazid
ahpC 2726390 c.198G>C synonymous_variant 0.22 isoniazid
ahpC 2726393 c.201G>C synonymous_variant 0.24 isoniazid
ahpC 2726397 p.Ser69Gly missense_variant 0.23 isoniazid
ahpC 2726408 c.216T>C synonymous_variant 0.2 isoniazid
ahpC 2726495 p.Asn101Lys missense_variant 0.2 isoniazid
ahpC 2726506 p.Thr105Lys missense_variant 0.27 isoniazid Uncertain significance
ahpC 2726508 c.316_318delTTAinsCG frameshift_variant&missense_variant 0.32 isoniazid Uncertain significance
ahpC 2726528 c.336C>G synonymous_variant 0.33 isoniazid
ahpC 2726540 c.348C>G synonymous_variant 0.33 isoniazid
ahpC 2726543 c.351A>G synonymous_variant 0.33 isoniazid
ahpC 2726546 c.354C>G synonymous_variant 0.3 isoniazid
ahpC 2726551 p.Gln120Leu missense_variant 0.3 isoniazid
ahpC 2726556 c.364_366delGCAinsAC frameshift_variant&missense_variant 0.3 isoniazid Uncertain significance
ahpC 2726561 c.369T>C synonymous_variant 0.35 isoniazid
ahpC 2726564 c.372C>G synonymous_variant 0.35 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.4 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.41 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.41 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.41 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.43 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.4 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.36 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.27 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.27 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.29 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.27 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.27 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.22 isoniazid
folC 2747239 c.360T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747248 c.351G>C synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747264 p.Gly112Ala missense_variant 0.3 para-aminosalicylic_acid
folC 2747266 c.333C>T synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.34 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.35 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747298 p.Leu101Val missense_variant 0.32 para-aminosalicylic_acid
folC 2747299 c.300C>T synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747302 c.297A>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.38 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.43 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.41 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.4 para-aminosalicylic_acid
Rv2477c 2782432 c.1609_1611delGTGinsAC frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782441 c.1602G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782450 c.1593C>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782513 c.1530G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.39 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.51 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2681 2996278 c.-461T>C upstream_gene_variant 0.23 capreomycin
Rv2681 2996287 c.-452A>C upstream_gene_variant 0.23 capreomycin
Rv2680 2996294 p.Ile64Val missense_variant 0.22 capreomycin
Rv2680 2996310 p.Leu69Arg missense_variant 0.21 capreomycin
Rv2680 2996315 p.Val71Ile missense_variant 0.2 capreomycin
Rv2681 2996912 c.174C>T synonymous_variant 0.98 capreomycin Not assoc w R
Rv2681 2997222 p.Thr162Ala missense_variant 0.19 capreomycin
Rv2681 2997242 c.504C>G synonymous_variant 0.29 capreomycin
Rv2681 2997260 c.522G>C synonymous_variant 0.27 capreomycin
Rv2681 2997263 c.525A>G synonymous_variant 0.27 capreomycin
Rv2681 2997267 c.529_531delTCGinsGC frameshift_variant&missense_variant 0.26 capreomycin Uncertain significance
Rv2681 2997271 p.Ala178Glu missense_variant 0.26 capreomycin
Rv2681 2997278 c.540G>C synonymous_variant 0.33 capreomycin
Rv2681 2997287 c.549G>C synonymous_variant 0.37 capreomycin
Rv2681 2997291 c.553T>C synonymous_variant 0.36 capreomycin
Rv2681 2997314 c.576A>G synonymous_variant 0.25 capreomycin
Rv2681 2997317 c.579A>G synonymous_variant 0.24 capreomycin
Rv2681 2997330 p.Ser198Ala missense_variant 0.24 capreomycin
Rv2681 2997333 p.Arg199Glu missense_variant 0.24 capreomycin
Rv2681 2997338 c.600G>C synonymous_variant 0.25 capreomycin
Rv2681 2997341 c.603G>C synonymous_variant 0.24 capreomycin
Rv2681 2997346 p.Glu203Gly missense_variant 0.25 capreomycin
Rv2681 2997350 c.612A>G synonymous_variant 0.24 capreomycin Not assoc w R - Interim
Rv2752c 3064632 c.1560C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv2752c 3065142 c.1050A>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065151 c.1041G>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065183 p.Ser337Ala missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065190 p.Ile334Met missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065205 c.987T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065210 c.982T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065223 c.969T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065229 c.963G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065232 c.960T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065262 c.930G>A synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065268 c.924A>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065397 c.795G>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065400 c.792A>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065553 c.639A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065562 c.630T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065569 p.Ile208Asn missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065946 c.246G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 p.Leu79Phe missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.28 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066009 c.183G>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066045 c.147T>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066118 p.Asn25Ser missense_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066249 c.-58C>T upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066261 c.-70G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066270 c.-79G>A upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066276 c.-85G>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066279 c.-88A>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066282 c.-91G>T upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066287 c.-96G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066290 c.-99G>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066291 c.-100G>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066309 c.-118T>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066315 c.-124C>T upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066330 c.-139G>C upstream_gene_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066339 c.-148G>C upstream_gene_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066370 c.-180_-179delAGinsGC upstream_gene_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066380 c.-189A>G upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066396 c.-207_-205delGCGinsAC upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066399 c.-210_-208delATTinsTCC upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066435 c.-246_-244delGGTinsAAC upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066452 c.-261T>A upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066453 c.-262G>A upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066462 c.-271G>A upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066465 c.-276_-274delGGGinsAAT upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066638 c.-447T>G upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066642 c.-453_-451delTTGinsCC upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066654 c.-463G>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066657 c.-466C>G upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-567_-565delCGGinsAC upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066762 c.-571G>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066864 c.-673C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066867 c.-676T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067349 c.597G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.45 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.61 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.65 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.63 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.62 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.66 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.65 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.57 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.51 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.52 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.44 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.41 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.41 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067736 c.208_210delTTCinsCT frameshift_variant&missense_variant 0.46 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.47 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.5 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.31 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.28 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.31 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.37 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073923 c.547_549delTTGinsCA frameshift_variant&missense_variant 0.38 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073947 c.525G>A synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.26 para-aminosalicylic_acid
thyA 3074055 p.Glu139Pro missense_variant 0.26 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.29 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074241 c.231C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074595 c.-124C>A upstream_gene_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087318 p.Glu167Lys missense_variant 0.21 cycloserine
ald 3087635 c.816C>T synonymous_variant 0.22 cycloserine
ald 3087641 c.822T>C synonymous_variant 0.23 cycloserine
ald 3087647 c.828A>G synonymous_variant 0.23 cycloserine
ald 3087649 p.Gly277Asp missense_variant 0.24 cycloserine
ald 3087653 c.834A>G synonymous_variant 0.24 cycloserine
ald 3087656 c.837A>G synonymous_variant 0.26 cycloserine
ald 3087665 c.846C>G synonymous_variant 0.24 cycloserine
ald 3087666 p.Tyr283His missense_variant 0.24 cycloserine
ald 3087672 p.His285Asp missense_variant 0.3 cycloserine
ald 3087680 c.861G>C synonymous_variant 0.34 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.35 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.33 cycloserine
ald 3087726 p.Ala303Ser missense_variant 0.31 cycloserine
ald 3087729 p.Ser304Ala missense_variant 0.31 cycloserine
ald 3087737 c.918G>C synonymous_variant 0.31 cycloserine
ald 3087749 c.930C>G synonymous_variant 0.29 cycloserine
ald 3087750 p.Tyr311Val missense_variant 0.29 cycloserine
ald 3087761 c.942C>G synonymous_variant 0.35 cycloserine
ald 3087770 c.951G>C synonymous_variant 0.36 cycloserine
ald 3087787 p.Glu323Ala missense_variant 0.33 cycloserine
ald 3087791 c.972T>C synonymous_variant 0.33 cycloserine
ald 3087797 p.Asp326Glu missense_variant 0.32 cycloserine
ald 3087799 p.His327Arg missense_variant 0.33 cycloserine
ald 3087821 c.1002G>A synonymous_variant 0.2 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
whiB7 3568732 c.-53C>T upstream_gene_variant 1.0 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
lpqB 3623528 c.1383G>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623531 c.1380T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3623549 c.1362C>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.21 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3623587 p.Ala442Pro missense_variant 0.2 bedaquiline
rifampicin
lpqB 3623630 c.1281G>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3623648 c.1263A>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624014 c.897T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624026 p.Glu295Asp missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624030 p.Ala294Arg missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624032 c.879T>C synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624037 c.874A>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624041 p.Glu290Asp missense_variant 0.24 bedaquiline
rifampicin
lpqB 3624050 c.861C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624077 c.834G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624638 c.273C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624671 c.238_240delGCCinsTG frameshift_variant&missense_variant 0.24 bedaquiline
rifampicin Uncertain significance
lpqB 3624680 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.34 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.33 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.29 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625201 c.-291T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.22 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625225 c.-315G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625510 c.-600T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.4 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.42 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625633 c.981C>T synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625636 c.978C>G synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.43 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.49 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.54 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625909 c.-999T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625920 c.694C>T synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3626124 p.Ala164Ser missense_variant 0.21 bedaquiline
rifampicin
mtrB 3626125 c.489C>G synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3626155 c.457_459delGCGinsTC frameshift_variant&missense_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626158 c.456C>T synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626467 c.147G>A synonymous_variant 0.97 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3626687 c.-74G>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.4 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627065 c.-452G>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.55 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.65 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.63 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.5 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.42 bedaquiline
rifampicin
mtrB 3627360 c.-747G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
fbiB 3642587 p.Met351Ile missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642593 c.1059G>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642609 c.1075_1076delAGinsTC synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642617 c.1083C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642731 c.1197C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642749 c.1215T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642758 c.1224C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3642763 p.Asp410Ala missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642770 c.1236G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642779 c.1245A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
rpoA 3877494 p.Glu338Asp missense_variant 0.27 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.31 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.35 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.44 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.5 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.55 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.62 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.58 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.57 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.56 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.54 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.45 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.41 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.44 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.4 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.38 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.39 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.36 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.34 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.33 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.41 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.4 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.36 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.29 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.3 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.29 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.24 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.2 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.18 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.22 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.23 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.24 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.28 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.3 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.34 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>A synonymous_variant 0.35 rifampicin
rpoA 3878172 c.336G>C synonymous_variant 0.36 rifampicin
rpoA 3878175 c.333G>C synonymous_variant 0.36 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.35 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.33 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.36 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.37 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.4 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.41 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.38 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.38 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.38 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.41 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.39 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.39 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.36 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.34 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.35 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.33 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.33 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.31 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.31 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.32 rifampicin
rpoA 3878463 c.45C>A synonymous_variant 0.29 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.21 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.38 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.54 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.54 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.55 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.52 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.51 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.51 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.52 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.53 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.45 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.48 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.49 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.47 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.49 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.46 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.38 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.36 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.4 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.41 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.49 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.49 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.51 rifampicin Uncertain significance
rpoA 3878932 c.-425G>A upstream_gene_variant 0.48 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.49 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.47 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.45 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.48 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.49 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.49 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.49 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.57 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.53 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.55 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.65 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.64 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.62 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.64 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.61 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.6 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.43 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.36 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.37 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.38 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.42 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.24 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986672 c.-172G>A upstream_gene_variant 0.2 delamanid
pretomanid
clpC1 4038255 p.Val817Lys missense_variant 0.21 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.21 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.2 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.27 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.27 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.27 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.28 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.32 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.36 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.36 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.35 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.35 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.41 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.44 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.44 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.41 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.43 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.45 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.41 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.4 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.48 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.46 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.47 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.63 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.61 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.6 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.51 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.49 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.36 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.4 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.4 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.45 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.42 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.38 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.38 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.33 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.32 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.38 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.45 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.43 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.27 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.3 pyrazinamide
clpC1 4040210 c.495G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.29 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.34 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.35 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.43 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.46 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.41 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.39 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.34 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.32 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.28 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
panD 4044635 c.-354G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044643 c.-362G>T upstream_gene_variant 0.21 pyrazinamide
panD 4044647 c.-366C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044650 c.-369G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044662 c.-381C>G upstream_gene_variant 0.23 pyrazinamide
panD 4044668 c.-387G>C upstream_gene_variant 0.24 pyrazinamide
panD 4044672 c.-392_-391delGCinsCA upstream_gene_variant 0.24 pyrazinamide
panD 4044675 c.-394T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044682 c.-401C>A upstream_gene_variant 0.29 pyrazinamide
panD 4044688 c.-407T>C upstream_gene_variant 0.31 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.34 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.35 pyrazinamide
panD 4044704 c.-423G>C upstream_gene_variant 0.38 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.44 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.45 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.51 pyrazinamide
panD 4044740 c.-459C>T upstream_gene_variant 0.48 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.44 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.43 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.4 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.4 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.4 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.43 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.47 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.44 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.46 pyrazinamide
panD 4044833 c.-552A>G upstream_gene_variant 0.42 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.44 pyrazinamide
panD 4044848 c.-567T>A upstream_gene_variant 0.43 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.46 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.45 pyrazinamide
panD 4044872 c.-591C>G upstream_gene_variant 0.45 pyrazinamide
panD 4044890 c.-609G>C upstream_gene_variant 0.32 pyrazinamide
panD 4044895 c.-614A>G upstream_gene_variant 0.32 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.32 pyrazinamide
panD 4044902 c.-623_-621delACGinsGC upstream_gene_variant 0.33 pyrazinamide
panD 4044908 c.-628_-627delCTinsTC upstream_gene_variant 0.31 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.35 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.36 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.34 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.34 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 0.35 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.33 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.41 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.39 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.4 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.34 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.35 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.41 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.38 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.41 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.43 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.39 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.36 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.34 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.36 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.35 pyrazinamide
panD 4045094 c.-813T>C upstream_gene_variant 0.29 pyrazinamide
panD 4045097 c.-816T>C upstream_gene_variant 0.27 pyrazinamide
panD 4045105 c.-824T>C upstream_gene_variant 0.25 pyrazinamide
panD 4045112 c.-831A>G upstream_gene_variant 0.23 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138418 c.1338T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138424 c.1332T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138429 c.1327T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138460 c.1296C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1266G>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138517 p.Glu413Ala missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>A synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>A synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138604 c.1150_1152delTTGinsCA frameshift_variant&missense_variant 0.42 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138610 c.1146C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139132 c.624A>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139135 c.619_621delGATinsAC frameshift_variant&synonymous_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139143 c.613T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139195 c.561G>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139198 c.558C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139207 c.549T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139537 c.219G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139541 p.Ile72Thr missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139545 c.211T>C synonymous_variant 0.21 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139554 p.Ala68Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139561 c.195G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.27 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139684 c.72C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240222 c.360G>C synonymous_variant 0.2 ethambutol
embC 4240229 p.Leu123Met missense_variant 0.19 ethambutol
embC 4240233 p.Gln124Leu missense_variant 0.19 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.25 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.26 ethambutol
embC 4240651 c.789G>A synonymous_variant 0.36 ethambutol
embC 4240669 c.807G>C synonymous_variant 0.41 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240677 p.Gly272Ala missense_variant 0.39 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.4 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.33 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.28 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.27 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.29 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.42 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.42 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.4 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.43 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.44 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.44 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.46 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.46 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.45 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.42 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.4 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.39 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.42 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.43 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.41 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.4 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.35 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.23 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.79 ethambutol Not assoc w R
embC 4241089 c.1227C>G synonymous_variant 0.26 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.29 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.28 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.28 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.27 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.27 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.29 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.28 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.23 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.2 ethambutol
embC 4241233 c.1371G>C synonymous_variant 0.18 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.27 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.3 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.31 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.34 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.33 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.28 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.29 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.33 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.36 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.33 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.36 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.4 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.39 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.4 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.38 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.38 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.33 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.33 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.32 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.3 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.3 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.22 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.23 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242779 p.Asn973Asp missense_variant 0.21 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.24 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.25 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.29 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.29 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.29 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.28 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.24 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.24 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.25 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.25 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.24 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.24 ethambutol
embA 4243848 p.Val206Met missense_variant 1.0 ethambutol Not assoc w R
embA 4244576 c.1344G>A synonymous_variant 0.3 ethambutol
embA 4244582 c.1350T>C synonymous_variant 0.31 ethambutol
embA 4244585 c.1353A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embA 4244611 p.Ala460Gly missense_variant 0.29 ethambutol
embA 4244616 p.Ala462Ser missense_variant 0.22 ethambutol
embA 4245041 c.1809C>G synonymous_variant 0.3 ethambutol
embA 4245044 c.1812G>C synonymous_variant 0.31 ethambutol
embA 4245053 c.1821G>C synonymous_variant 0.32 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.33 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.35 ethambutol
embA 4245086 c.1854C>G synonymous_variant 0.33 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.33 ethambutol
embA 4245098 c.1866C>T synonymous_variant 0.42 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.42 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.44 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.42 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.44 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.42 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.38 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.35 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.37 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.35 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.35 ethambutol
embA 4245218 c.1986C>T synonymous_variant 0.63 ethambutol Not assoc w R
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.38 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.33 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.31 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.27 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.27 ethambutol
embA 4245290 c.2058C>G synonymous_variant 0.27 ethambutol
embA 4245293 c.2061T>G synonymous_variant 0.28 ethambutol
embA 4245296 c.2064G>C synonymous_variant 0.28 ethambutol
embA 4245299 c.2067A>G synonymous_variant 0.28 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.22 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.22 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.23 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.21 ethambutol
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246064 c.-450T>C upstream_gene_variant 0.21 ethambutol
embA 4246080 c.2848_2850delCCTinsTC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
embA 4246088 c.2856A>G synonymous_variant 0.24 ethambutol Not assoc w R
embB 4246097 c.-417C>G upstream_gene_variant 0.24 ethambutol
embA 4246103 c.2871C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4246109 c.-405C>G upstream_gene_variant 0.25 ethambutol
embB 4246115 c.-399T>G upstream_gene_variant 0.24 ethambutol
embA 4246128 c.2896_2898delTCTinsAC frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
embA 4246138 p.Arg969Gln missense_variant 0.22 ethambutol
embA 4246143 p.Ile971Val missense_variant 0.21 ethambutol
embA 4246153 p.Ala974Glu missense_variant 0.19 ethambutol
embB 4246157 c.-357A>G upstream_gene_variant 0.26 ethambutol
embA 4246164 c.2932T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4246184 c.-330A>C upstream_gene_variant 0.32 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.27 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.22 ethambutol
embB 4246211 c.-303T>C upstream_gene_variant 0.22 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.19 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.27 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.28 ethambutol
embB 4246274 c.-240G>A upstream_gene_variant 0.29 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.32 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.3 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.29 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.3 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.28 ethambutol
embA 4246329 p.Thr1033Leu missense_variant 0.27 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.27 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
embB 4246367 c.-147C>T upstream_gene_variant 0.24 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.23 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.24 ethambutol
embA 4246379 c.3147C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247425 c.912G>C synonymous_variant 0.23 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.24 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.25 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.25 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.31 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.36 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.44 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.44 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.45 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.46 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.42 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.45 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.45 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.44 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.44 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.43 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.42 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.29 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.27 ethambutol
embB 4247638 c.1125G>C synonymous_variant 0.24 ethambutol
embB 4247646 p.Glu378Ala missense_variant 0.97 ethambutol Not assoc w R
embB 4247683 c.1170C>G synonymous_variant 0.22 ethambutol
embB 4247692 c.1179C>G synonymous_variant 0.22 ethambutol
embB 4247716 c.1203C>T synonymous_variant 0.2 ethambutol
embB 4247722 c.1209G>C synonymous_variant 0.21 ethambutol
embB 4247729 c.1216_1218delGGCinsCG frameshift_variant&missense_variant 0.21 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.27 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.31 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.35 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.34 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.43 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.44 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.44 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.45 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.42 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.45 ethambutol
embB 4247836 c.1323A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.51 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.49 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.5 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.49 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.49 ethambutol Not assoc w R - Interim
embB 4247899 p.Met462Ile missense_variant 0.51 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.5 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.5 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.47 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.45 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.44 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.4 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.36 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.38 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.38 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.31 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.31 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.31 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.31 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.31 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.31 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.28 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.36 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.36 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.35 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.35 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.35 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.39 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.39 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.39 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.38 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.38 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.4 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.33 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.3 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.32 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.33 ethambutol
embB 4248355 c.1842A>C synonymous_variant 0.33 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.31 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.32 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.3 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.29 ethambutol
embB 4248407 p.Leu632Val missense_variant 0.21 ethambutol
embB 4248410 c.1897_1899delTTCinsCG frameshift_variant&missense_variant 0.22 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.21 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248432 p.Trp640Phe missense_variant 0.21 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.21 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.27 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.28 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.28 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.29 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.29 ethambutol
embB 4249435 c.2922G>A synonymous_variant 0.3 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.36 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.39 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.39 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.4 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.38 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.34 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.32 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.31 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.31 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.28 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.28 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.27 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.26 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.27 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.23 ethambutol
aftB 4267241 c.1596G>C synonymous_variant 0.24 ethambutol
aftB 4267244 c.1593T>C synonymous_variant 0.26 ethambutol
aftB 4267256 c.1581C>G synonymous_variant 0.24 ethambutol
aftB 4267262 c.1575T>C synonymous_variant 0.24 ethambutol
aftB 4267266 p.Ala524Gly missense_variant 0.24 ethambutol
aftB 4267268 c.1569T>C synonymous_variant 0.23 ethambutol
aftB 4267274 c.1563G>C synonymous_variant 0.21 ethambutol
aftB 4267289 p.Ala516Gln missense_variant 0.21 ethambutol
aftB 4267292 c.1545C>G synonymous_variant 0.21 ethambutol
aftB 4267301 c.1536C>T synonymous_variant 0.2 ethambutol
aftB 4267304 p.Val511Ala missense_variant 0.21 ethambutol
aftB 4267316 c.1521A>G synonymous_variant 0.25 ethambutol
aftB 4267325 c.1512G>C synonymous_variant 0.23 ethambutol
aftB 4267334 c.1503T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
aftB 4267535 c.1302A>G synonymous_variant 0.2 ethambutol
aftB 4267544 p.Asp431Gly missense_variant 0.21 ethambutol
aftB 4267547 c.1290C>G synonymous_variant 0.21 ethambutol
aftB 4267574 c.1263G>A synonymous_variant 0.3 ethambutol
aftB 4267580 c.1257G>T synonymous_variant 0.32 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.21 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.22 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.22 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.21 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.23 ethambutol
aftB 4268236 p.Leu201Met missense_variant 0.21 ethambutol
ubiA 4269031 p.Gly268Asp missense_variant 0.85 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R