TB-Profiler result

Run: SRR1183144
Summary

Run ID: SRR1183144

Sample name:

Date: 2024-03-27T01:42:54.683287

Number of reads: 1653024

Percentage reads mapped: 54.96

Median coverage: 36.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8.1 M.bovis None 0.06
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Met482Ile Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine pepQ c.592_594delGCCinsTG Assoc w R - Interim
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.820_822delTTAinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.895_897delGAAinsCT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1945_1947delATTinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.592_594delGCCinsTG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.31 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.34 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303750 c.820_822delTTAinsCG frameshift_variant&missense_variant 0.3 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.31 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303825 c.895_897delGAAinsCT frameshift_variant&missense_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304875 c.1945_1947delATTinsGG frameshift_variant&missense_variant 0.44 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pepQ 2859825 c.592_594delGCCinsTG frameshift_variant&missense_variant 0.28 clofazimine Assoc w R - Interim
bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
embB 4247448 p.His312Arg missense_variant 0.36 ethambutol Mutation from literature
embB 4247959 p.Met482Ile missense_variant 0.25 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 558 c.558G>C synonymous_variant 0.23 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.2 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 588 c.588A>G synonymous_variant 0.2 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.2 isoniazid
dnaA 594 c.594C>G synonymous_variant 0.21 isoniazid
dnaA 597 c.597C>T synonymous_variant 0.21 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.22 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.21 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.21 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.22 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.25 isoniazid
dnaA 909 c.909A>G synonymous_variant 0.26 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.27 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.27 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.28 isoniazid
dnaA 930 c.930G>A synonymous_variant 0.29 isoniazid
dnaA 939 c.939C>T synonymous_variant 0.29 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.27 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.27 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.23 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.24 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.21 isoniazid
dnaA 975 c.975G>A synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 984 c.984T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>C synonymous_variant 0.23 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.22 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.22 isoniazid
dnaA 1002 c.1002G>A synonymous_variant 0.23 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1020 c.1020C>G synonymous_variant 0.24 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.23 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.23 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.34 isoniazid
dnaA 1038 c.1038A>C synonymous_variant 0.37 isoniazid
dnaA 1050 c.1050G>A synonymous_variant 0.36 isoniazid
dnaA 1053 c.1053C>T synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 1077 c.1077A>G synonymous_variant 0.45 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.41 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.43 isoniazid
dnaA 1107 c.1107C>T synonymous_variant 0.42 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.4 isoniazid
dnaA 1122 c.1122C>A synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 1125 c.1125G>C synonymous_variant 0.37 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.3 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.22 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.24 isoniazid
dnaA 1203 c.1203T>C synonymous_variant 0.24 isoniazid
dnaA 1215 c.1215C>T synonymous_variant 0.28 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.25 isoniazid
dnaA 1224 c.1224C>G synonymous_variant 0.26 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.28 isoniazid
dnaA 1239 c.1239G>A synonymous_variant 0.27 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.27 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.32 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.26 isoniazid
dnaA 1299 c.1299G>T synonymous_variant 0.22 isoniazid
dnaA 1317 c.1317A>C synonymous_variant 0.28 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 1329 c.1329A>G synonymous_variant 0.32 isoniazid
dnaA 1332 c.1332A>G synonymous_variant 0.33 isoniazid
dnaA 1338 c.1338T>C synonymous_variant 0.31 isoniazid
dnaA 1347 c.1347C>T synonymous_variant 0.34 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.34 isoniazid
dnaA 1356 c.1356T>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 1371 c.1371T>G synonymous_variant 0.44 isoniazid
dnaA 1374 c.1374G>A synonymous_variant 0.44 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.49 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.38 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.38 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.41 isoniazid
dnaA 1428 c.1428C>A synonymous_variant 0.31 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.29 isoniazid
dnaA 1434 c.1434C>A synonymous_variant 0.31 isoniazid
dnaA 1437 c.1437G>A synonymous_variant 0.3 isoniazid
dnaA 1441 c.1441C>T synonymous_variant 0.32 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.29 isoniazid
gyrB 6145 c.906C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6151 c.912C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6721 c.1482C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6730 c.-572A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6781 c.-521C>T upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6802 c.1563G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6850 c.1611C>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6941 c.-361C>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6970 p.Asp577Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7018 c.-284G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7793 c.492G>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7838 c.537C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8096 c.795T>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8321 c.1020C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.21 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8486 c.1185T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8492 c.1191G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8507 c.1206C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8510 c.1209G>A synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8528 c.1227G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8664 c.1363C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8723 c.1422G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8783 c.1482G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8855 c.1554C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8983 p.Cys561Ser missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.41 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9099 c.1798T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.21 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9185 c.1884C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9192 c.1891C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9203 c.1902G>A synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9242 c.1941A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9251 c.1950G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 490797 c.15G>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 490803 c.21T>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 490818 c.36C>T synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490830 c.48A>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>T synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 490857 c.75C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 490869 c.87C>A synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491022 c.240C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491058 c.276C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491112 c.330G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491538 c.756G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491623 p.Ala281Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575548 c.201C>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575557 c.210C>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.19 ethionamide
isoniazid
mshA 575611 c.264C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575761 c.414C>T synonymous_variant 0.24 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575771 p.Val142Ser missense_variant 0.23 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.23 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.29 ethionamide
isoniazid
mshA 575851 c.504C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575860 c.513G>A synonymous_variant 0.32 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.65 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.34 ethionamide
isoniazid
mshA 575924 p.Gly193Ile missense_variant 0.37 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575971 c.624C>T synonymous_variant 0.17 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGG upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619540 c.-351C>G upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619615 c.-276C>T upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>T upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619647 c.-244T>C upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>G upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620269 p.Val127Ile missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>T synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>T synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.25 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.2 ethionamide
Rv0565c 657647 c.-179_-177delGTCinsAT upstream_gene_variant 0.21 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.23 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.24 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.23 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.23 ethionamide
hadA 731729 c.-201C>T upstream_gene_variant 0.16 isoniazid
hadA 731753 c.-177A>T upstream_gene_variant 0.25 isoniazid
hadA 731768 c.-162G>A upstream_gene_variant 0.33 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.32 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.37 isoniazid
hadA 731798 c.-132C>G upstream_gene_variant 0.34 isoniazid
hadA 731825 c.-105G>C upstream_gene_variant 0.25 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.2 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.2 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.19 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.3 isoniazid
hadA 732358 c.429G>A synonymous_variant 0.34 isoniazid
hadA 732361 c.432C>T synonymous_variant 0.41 isoniazid
hadA 732370 c.441C>T synonymous_variant 0.48 isoniazid
hadA 732374 c.445_447delGATinsAC frameshift_variant&missense_variant 0.5 isoniazid Uncertain significance
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.52 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.62 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.65 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.29 rifampicin
nusG 734415 c.162C>T synonymous_variant 0.36 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.38 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.38 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.46 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.47 rifampicin
nusG 734457 c.204C>T synonymous_variant 0.45 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.45 rifampicin
nusG 734505 c.252G>A synonymous_variant 0.45 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.36 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.32 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.29 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.26 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.24 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.24 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.29 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.33 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734847 c.594T>C synonymous_variant 0.36 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.36 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.34 rifampicin
nusG 734870 p.Ser206Asn missense_variant 0.36 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.36 rifampicin
nusG 734905 c.652C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734910 c.657C>G synonymous_variant 0.3 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.3 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.25 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760145 c.339C>G synonymous_variant 0.36 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.47 rifampicin
rpoB 760307 c.501T>C synonymous_variant 0.4 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.43 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.55 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760356 c.550_552delACCinsTG frameshift_variant&missense_variant 0.48 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.45 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.44 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.34 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.34 rifampicin Uncertain significance
rpoB 760533 p.Val243His missense_variant 0.38 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760556 c.750G>A synonymous_variant 0.3 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.23 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.33 rifampicin
rpoB 760598 c.792C>T synonymous_variant 0.34 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.37 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.35 rifampicin
rpoB 760754 c.948G>C synonymous_variant 0.33 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.33 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.33 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.32 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.33 rifampicin
rpoB 760796 c.990A>G synonymous_variant 0.29 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.29 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.27 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.3 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760845 c.1039_1041delACCinsTG frameshift_variant&missense_variant 0.32 rifampicin
rpoB 760850 c.1044G>C synonymous_variant 0.32 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760862 c.1056G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.35 rifampicin
rpoB 760877 c.1071G>T synonymous_variant 0.38 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.38 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.34 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.28 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.26 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>T synonymous_variant 0.39 rifampicin
rpoB 760970 c.1164G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>T synonymous_variant 0.41 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.33 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.39 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.42 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.41 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>A synonymous_variant 0.4 rifampicin
rpoB 761168 c.1362C>G synonymous_variant 0.38 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.4 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 0.4 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>T synonymous_variant 0.4 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.39 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.4 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.4 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.45 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.45 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.44 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.49 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.48 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.44 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.43 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.42 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.36 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.33 rifampicin
rpoB 761465 c.1659G>T synonymous_variant 0.33 rifampicin
rpoB 761471 c.1665C>T synonymous_variant 0.31 rifampicin
rpoB 761477 c.1671C>T synonymous_variant 0.29 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.28 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.29 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.28 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.33 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.33 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761540 c.1734C>T synonymous_variant 0.36 rifampicin
rpoB 761561 c.1755C>G synonymous_variant 0.41 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761582 c.1776G>A synonymous_variant 0.42 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.4 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.26 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.29 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.28 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.26 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.21 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.29 rifampicin
rpoB 761819 c.2013G>A synonymous_variant 0.29 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>A synonymous_variant 0.24 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.23 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.39 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.3 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.3 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.3 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.3 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.31 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.32 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.38 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761955 p.Ile717Val missense_variant 0.39 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.47 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.46 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762050 c.2244G>A synonymous_variant 0.44 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.43 rifampicin Uncertain significance
rpoB 762138 c.2332C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.44 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.43 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.29 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.28 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.27 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.22 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.23 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.24 rifampicin
rpoB 762368 c.2562G>A synonymous_variant 0.21 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.22 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.21 rifampicin
rpoC 762401 c.-969G>T upstream_gene_variant 0.23 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.28 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.27 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762507 c.2701_2703delCTTinsAG frameshift_variant&missense_variant 0.38 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.35 rifampicin Uncertain significance
rpoC 762524 c.-846G>C upstream_gene_variant 0.3 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.26 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.26 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.26 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.23 rifampicin
rpoB 762833 c.3027C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.52 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.39 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763082 c.-288C>G upstream_gene_variant 0.51 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>A upstream_gene_variant 0.53 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.5 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.35 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.36 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.27 rifampicin
rpoC 763199 c.-171G>T upstream_gene_variant 0.22 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.17 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.18 rifampicin
rpoC 763211 c.-159C>T upstream_gene_variant 0.17 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.22 rifampicin
rpoC 763423 c.54G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.24 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>A synonymous_variant 0.38 rifampicin
rpoC 763573 c.204G>T synonymous_variant 0.4 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>A synonymous_variant 0.38 rifampicin
rpoC 763618 c.249C>T synonymous_variant 0.38 rifampicin
rpoC 763621 c.252C>G synonymous_variant 0.37 rifampicin
rpoC 763636 c.267T>G synonymous_variant 0.3 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763681 c.312C>A synonymous_variant 0.44 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.48 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.56 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.5 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.5 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.47 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.43 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.4 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.4 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.41 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.46 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.41 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.4 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.44 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.44 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.43 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.44 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.46 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.3 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.23 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.26 rifampicin
rpoC 763969 c.600C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.31 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.33 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.34 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.37 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764024 c.655T>C synonymous_variant 0.5 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.41 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.42 rifampicin
rpoC 764056 c.687G>T synonymous_variant 0.41 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.41 rifampicin
rpoC 764080 c.711C>T synonymous_variant 0.45 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.45 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>G synonymous_variant 0.32 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.26 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764218 c.849C>T synonymous_variant 0.33 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.32 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.36 rifampicin
rpoC 764260 c.891G>A synonymous_variant 0.35 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.35 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.43 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.42 rifampicin
rpoC 764339 c.970C>T synonymous_variant 0.43 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.32 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.27 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.29 rifampicin
rpoC 764452 c.1083T>G synonymous_variant 0.27 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.27 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.36 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.54 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.62 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.63 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.57 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764782 c.1413C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.35 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.27 rifampicin
rpoC 764857 c.1488G>T synonymous_variant 0.24 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.2 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.19 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.22 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.33 rifampicin
rpoC 764908 c.1539G>A synonymous_variant 0.33 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.42 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>T synonymous_variant 0.39 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765343 c.1974G>A synonymous_variant 0.24 rifampicin
rpoC 765367 c.1998C>G synonymous_variant 0.22 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.21 rifampicin Uncertain significance
rpoC 765404 c.2035C>T synonymous_variant 0.25 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>T synonymous_variant 0.37 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>A synonymous_variant 0.42 rifampicin
rpoC 765529 c.2160C>T synonymous_variant 0.38 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.36 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.39 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.34 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.36 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.38 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.41 rifampicin
rpoC 765592 c.2223C>T synonymous_variant 0.41 rifampicin
rpoC 765622 p.Glu751Asp missense_variant 0.45 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765685 c.2316G>A synonymous_variant 0.43 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Lys missense_variant 0.37 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.39 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.31 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.31 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.26 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.26 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.25 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.23 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.36 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.38 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765907 c.2538G>A synonymous_variant 0.4 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.47 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.36 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765991 c.2622C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>A synonymous_variant 0.28 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766027 c.2658G>C synonymous_variant 0.2 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.21 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.24 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.25 rifampicin
rpoC 766096 c.2727G>T synonymous_variant 0.27 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.3 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.24 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.27 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.25 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.27 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.28 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.25 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.27 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.29 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.28 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.23 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.21 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.31 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.36 rifampicin
rpoC 766492 c.3123T>A synonymous_variant 0.4 rifampicin
rpoC 766500 p.Ala1044Val missense_variant 0.6 rifampicin Uncertain significance
rpoC 766522 c.3153C>G synonymous_variant 0.45 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.47 rifampicin
rpoC 766540 c.3171C>T synonymous_variant 0.47 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.46 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.46 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.5 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.51 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.5 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.47 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.51 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.38 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.38 rifampicin
rpoC 766666 c.3297C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.41 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.46 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.45 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.51 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.42 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.25 rifampicin
rpoC 766879 c.3510G>C synonymous_variant 0.2 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.23 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766954 c.3585C>T synonymous_variant 0.23 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.33 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.37 rifampicin
rpoC 767044 c.3675G>A synonymous_variant 0.4 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.39 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>A synonymous_variant 0.31 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.21 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.21 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.24 rifampicin
rpoC 767209 c.3840T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775943 c.2538C>G synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 775949 c.2532G>T synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.37 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.22 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776030 c.2451G>A synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.22 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.23 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.23 streptomycin
rpsL 781622 c.63C>G synonymous_variant 0.32 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.38 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.4 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.41 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.44 streptomycin
rpsL 781703 c.144G>A synonymous_variant 0.43 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.41 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.39 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.39 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.42 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.47 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.41 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.4 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.36 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.33 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.35 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.43 streptomycin
rpsL 781820 c.261G>T synonymous_variant 0.4 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.4 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.39 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.37 streptomycin
rpsL 781886 c.327C>T synonymous_variant 0.32 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.28 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.31 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.32 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.3 streptomycin
rplC 800516 c.-293G>T upstream_gene_variant 0.33 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.35 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.4 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.34 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.35 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.38 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.39 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.36 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.33 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.35 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.32 linezolid
rplC 800715 c.-94_-92delATCinsCT upstream_gene_variant 0.31 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.31 linezolid
rplC 800744 c.-65G>A upstream_gene_variant 0.29 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.3 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.27 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.27 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.21 linezolid
rplC 801171 c.363A>G synonymous_variant 0.26 linezolid
rplC 801174 c.366T>C synonymous_variant 0.26 linezolid
rplC 801195 c.387G>C synonymous_variant 0.26 linezolid
rplC 801207 c.399C>T synonymous_variant 0.24 linezolid
rplC 801228 c.420T>C synonymous_variant 0.23 linezolid
rplC 801378 c.570C>T synonymous_variant 0.32 linezolid
rplC 801402 c.594T>C synonymous_variant 0.28 linezolid
rplC 801405 c.597T>C synonymous_variant 0.26 linezolid
rplC 801408 c.600C>A synonymous_variant 0.26 linezolid
rplC 801417 c.609T>C synonymous_variant 0.23 linezolid
rplC 801423 c.615G>C synonymous_variant 0.21 linezolid
rplC 801426 c.618C>T synonymous_variant 0.22 linezolid
rplC 801427 p.Met207Val missense_variant 0.23 linezolid
rplC 801432 c.624C>T synonymous_variant 0.22 linezolid
rplC 801437 p.Ser210Thr missense_variant 0.22 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303480 p.Gln184Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303506 c.576C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303537 p.Arg203Leu missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303542 c.612C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303593 c.663G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303722 c.792C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303779 c.849G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304619 c.1689G>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304823 c.1893C>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304896 c.1966C>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304915 p.Asp662Gly missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304988 c.2058G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305114 p.Asp728Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305135 c.2205C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305201 c.2271G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305207 c.2277C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305215 p.Ser762Thr missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.17 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305273 c.2343C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364691 c.279T>C synonymous_variant 0.2 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.17 pyrazinamide
sigE 1364910 c.498G>C synonymous_variant 0.22 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.2 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.25 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.33 pyrazinamide
sigE 1364931 c.519C>G synonymous_variant 0.32 pyrazinamide
sigE 1364952 c.540A>C synonymous_variant 0.35 pyrazinamide
sigE 1364955 c.543G>C synonymous_variant 0.36 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.38 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.4 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.42 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.42 pyrazinamide
sigE 1365012 c.600G>C synonymous_variant 0.39 pyrazinamide
sigE 1365030 c.618C>T synonymous_variant 0.31 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.31 pyrazinamide
sigE 1365036 c.624T>C synonymous_variant 0.31 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.35 pyrazinamide
sigE 1365063 c.651A>T synonymous_variant 0.26 pyrazinamide
sigE 1365072 c.660G>C synonymous_variant 0.17 pyrazinamide
sigE 1365078 c.666C>G synonymous_variant 0.18 pyrazinamide
sigE 1365087 c.675A>C synonymous_variant 0.17 pyrazinamide
sigE 1365090 c.678T>C synonymous_variant 0.17 pyrazinamide
sigE 1365099 c.687A>C synonymous_variant 0.17 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416313 c.1035A>C synonymous_variant 0.2 ethambutol
embR 1416316 c.1032C>G synonymous_variant 0.18 ethambutol
embR 1416330 p.Val340Ile missense_variant 0.27 ethambutol
embR 1416335 p.Asn338Ser missense_variant 0.28 ethambutol
embR 1416343 c.1005G>C synonymous_variant 0.27 ethambutol
embR 1416364 c.984C>T synonymous_variant 0.26 ethambutol
embR 1416373 c.975C>G synonymous_variant 0.24 ethambutol
embR 1416376 c.972C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embR 1416386 p.Asp321Ala missense_variant 0.2 ethambutol
embR 1416388 c.960A>G synonymous_variant 0.21 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601_604delTCTC non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606_607insCGGG non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473676 n.19G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473987 n.330G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474002 n.345G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474007 n.350A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474156 n.499G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474163 n.506C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474286 n.629C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474306 n.651_655delGGTGG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474995 n.1338T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474999 n.1342C>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475007 n.1350C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475018 n.1361G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475446 n.1789G>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475487 n.1830C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475605 n.1948A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475637 n.1980T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475759 n.2102_2106delCCCGCinsTCGT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476047 n.2390G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476104 n.2448delG non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476595 n.2938C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476602 n.2945G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
inhA 1673721 c.-481C>T upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673727 c.-475C>T upstream_gene_variant 0.2 ethionamide
isoniazid Uncertain significance
fabG1 1673733 p.Met98Ile missense_variant 0.25 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.24 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.24 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673805 c.-397G>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673808 c.-394A>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1674765 c.564C>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674786 c.585G>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674792 c.591G>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674810 c.609C>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674813 c.612C>T synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.41 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674819 c.618G>T synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674840 c.639C>T synonymous_variant 0.46 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674846 p.Ile215Met missense_variant 0.47 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674900 c.699G>A synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.24 ethionamide
isoniazid
inhA 1674927 c.726G>A synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674939 c.738G>T synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.25 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.33 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.35 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833749 p.Ile70Leu missense_variant 0.65 pyrazinamide Not assoc w R
rpsA 1833760 c.219C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1833782 p.Ser81Thr missense_variant 0.33 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833799 c.258C>A synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833808 c.267G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.26 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.3 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.3 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.36 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833934 c.393C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1833949 c.408T>C synonymous_variant 0.4 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834279 c.738C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834282 c.741C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834444 c.903C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.41 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834517 c.976C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.38 pyrazinamide Uncertain significance
rpsA 1834609 c.1068T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834615 c.1074C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834624 c.1083G>A synonymous_variant 0.42 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.43 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.35 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.31 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.31 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.26 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.26 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.26 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.24 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.26 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.27 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.25 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.23 linezolid
tsnR 1853450 c.-156G>A upstream_gene_variant 0.19 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.18 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.21 linezolid
tsnR 1853468 c.-138C>T upstream_gene_variant 0.19 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.2 linezolid
tsnR 1853485 c.-121G>C upstream_gene_variant 0.19 linezolid
tsnR 1853489 c.-117C>T upstream_gene_variant 0.19 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063550 c.1179C>G synonymous_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063574 c.1155C>G synonymous_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063583 c.1146G>C synonymous_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063588 c.1141T>C synonymous_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063598 c.1131T>C synonymous_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064996 c.-268G>A upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101960 c.1083A>G synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2101964 p.Glu360Ala missense_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>A synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2101980 p.Asn355Asp missense_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2101987 c.1056C>G synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2101999 c.1044G>A synonymous_variant 0.33 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102020 c.1023A>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>T synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102035 c.1008C>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102230 c.813G>C synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102239 c.804C>T synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102242 c.801G>A synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102247 p.Val266Ile missense_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102260 c.783C>T synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102263 c.780G>A synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102305 c.738T>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102310 c.733C>T synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102671 c.372T>C synonymous_variant 0.21 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102680 c.363T>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102683 c.360T>C synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102686 c.357G>C synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102707 c.336C>T synonymous_variant 0.34 ethionamide
delamanid
isoniazid
ndh 2102710 c.333C>T synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102713 c.330C>T synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102718 p.Gln109Glu missense_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102722 c.321C>G synonymous_variant 0.3 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102731 c.312C>G synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102737 p.Glu102Asp missense_variant 0.31 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.41 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.38 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.38 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.44 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.41 isoniazid
kasA 2518010 c.-105C>G upstream_gene_variant 0.35 isoniazid
kasA 2518013 c.-102G>A upstream_gene_variant 0.29 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.27 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.2 isoniazid
kasA 2518630 c.516G>C synonymous_variant 0.24 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.19 isoniazid
kasA 2518645 c.531G>A synonymous_variant 0.19 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.27 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.34 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.36 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.4 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.43 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.43 isoniazid
kasA 2518687 p.Asp191Glu missense_variant 0.43 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.42 isoniazid
kasA 2518717 c.603C>G synonymous_variant 0.45 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.49 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.47 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.46 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.44 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.42 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.44 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.41 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.33 isoniazid
kasA 2518846 c.732G>C synonymous_variant 0.25 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.34 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.29 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.29 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.29 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.26 isoniazid
kasA 2519077 c.963G>A synonymous_variant 0.27 isoniazid
kasA 2519086 c.972C>T synonymous_variant 0.3 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.25 isoniazid
kasA 2519098 c.984C>T synonymous_variant 0.26 isoniazid
kasA 2519104 c.990T>A synonymous_variant 0.26 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.26 isoniazid
kasA 2519110 p.Asp332Glu missense_variant 0.29 isoniazid
kasA 2519119 c.1005G>C synonymous_variant 0.35 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.44 isoniazid
kasA 2519146 c.1032C>G synonymous_variant 0.45 isoniazid
kasA 2519152 c.1038G>T synonymous_variant 0.44 isoniazid
kasA 2519161 c.1047G>A synonymous_variant 0.42 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.41 isoniazid
kasA 2519188 c.1074G>A synonymous_variant 0.35 isoniazid
kasA 2519197 c.1083G>C synonymous_variant 0.34 isoniazid
kasA 2519203 c.1089C>G synonymous_variant 0.32 isoniazid
kasA 2519206 c.1092C>T synonymous_variant 0.32 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.22 isoniazid
eis 2714526 c.805_806delAC frameshift_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
folC 2746584 c.1015T>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2746591 c.1008C>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2746597 c.1002C>G synonymous_variant 0.33 para-aminosalicylic_acid
folC 2746609 c.990T>C synonymous_variant 0.35 para-aminosalicylic_acid
folC 2746612 c.987C>T synonymous_variant 0.35 para-aminosalicylic_acid
folC 2746621 c.978C>G synonymous_variant 0.39 para-aminosalicylic_acid
folC 2746624 c.975C>G synonymous_variant 0.38 para-aminosalicylic_acid
folC 2746627 p.Asp324Glu missense_variant 0.39 para-aminosalicylic_acid
folC 2746631 p.Gly323Val missense_variant 0.41 para-aminosalicylic_acid
folC 2746657 c.942T>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2746663 c.936T>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2746960 c.639C>G synonymous_variant 0.3 para-aminosalicylic_acid
folC 2746975 c.624T>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2746978 p.Ala207Glu missense_variant 0.3 para-aminosalicylic_acid
folC 2746990 p.Asp203Glu missense_variant 0.29 para-aminosalicylic_acid
folC 2746999 c.600T>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747002 c.597T>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747007 p.Ser198Gly missense_variant 0.21 para-aminosalicylic_acid
folC 2747010 p.Ile197Val missense_variant 0.23 para-aminosalicylic_acid
folC 2747023 c.576C>G synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747029 c.570G>C synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747032 c.567A>G synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747053 c.546C>T synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747299 c.300C>T synonymous_variant 0.35 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.35 para-aminosalicylic_acid
folC 2747314 c.285A>T synonymous_variant 0.43 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.44 para-aminosalicylic_acid
folC 2747338 c.261C>T synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747341 c.256_258delGTCinsCG frameshift_variant&missense_variant 0.28 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.25 para-aminosalicylic_acid
folC 2747356 p.Met81Ile missense_variant 0.24 para-aminosalicylic_acid
folC 2747363 p.Ala79Val missense_variant 0.24 para-aminosalicylic_acid
folC 2747371 c.228C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747374 c.225G>A synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747377 c.222C>A synonymous_variant 0.23 para-aminosalicylic_acid
Rv2477c 2782822 c.1221G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782828 c.1215T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782831 c.1212G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782846 p.Arg399Lys missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782868 p.Ala392Ser missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782885 c.1158G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782942 c.1101C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782945 c.1098C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783128 c.915C>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.33 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783164 c.879G>A synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783167 c.876G>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783236 c.807G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783281 c.762G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783338 c.705C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.52 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783428 c.615C>T synonymous_variant 0.53 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783449 c.594C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783548 c.495T>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783650 c.393C>T synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783659 c.384A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783791 c.252C>T synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783836 c.207C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 p.Tyr29Phe missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>T upstream_gene_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784414 c.-372A>G upstream_gene_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784435 c.-393C>G upstream_gene_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784438 c.-396G>C upstream_gene_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784492 c.-450C>G upstream_gene_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859765 c.654G>C synonymous_variant 0.25 clofazimine
bedaquiline
pepQ 2859778 p.Val214Asp missense_variant 0.27 clofazimine
bedaquiline
pepQ 2859780 p.Gln213Ala missense_variant 0.26 clofazimine
bedaquiline
pepQ 2859783 c.636G>C synonymous_variant 0.26 clofazimine
bedaquiline
pepQ 2859786 c.633G>C synonymous_variant 0.27 clofazimine
bedaquiline
pepQ 2859828 c.591G>A synonymous_variant 0.26 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.25 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
pepQ 2859843 c.576G>C synonymous_variant 0.26 clofazimine
bedaquiline
pepQ 2859852 c.567A>G synonymous_variant 0.24 clofazimine
bedaquiline
Rv2752c 3064998 c.1194A>C synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065016 c.1176C>T synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065022 c.1170G>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065046 c.1146G>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065052 c.1140G>A synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065067 c.1125C>T synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065073 c.1119C>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065087 c.1105A>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid Not assoc w R - Interim
Rv2752c 3065088 c.1104A>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065097 c.1095C>T synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065457 c.735A>G synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065463 c.729T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065466 c.726G>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065475 c.717C>T synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065711 p.Gly161Ser missense_variant 0.97 ethambutol Not assoc w R
moxifloxacin Not assoc w R
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv2752c 3065901 c.291A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065908 p.Lys95Arg missense_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 c.276T>C synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065919 c.273G>A synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065922 c.270T>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065928 c.264G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065947 p.Gly82Ala missense_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065949 c.243C>T synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065957 c.235T>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065958 c.234G>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.39 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066006 c.186G>C synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066084 c.108C>T synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066504 c.-313C>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066513 c.-322C>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066543 c.-352C>A upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066560 c.-369C>T upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>T upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>A upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066582 c.-392_-391delCCinsGT upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066596 c.-405C>T upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066636 c.-445G>A upstream_gene_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066644 c.-453T>C upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067360 p.Ile196Val missense_variant 0.23 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067382 c.564C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067385 c.561C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067655 c.291G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067670 c.276G>A synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067676 c.270C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067715 p.Ser77Thr missense_variant 0.25 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067850 c.96A>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.42 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073932 c.540C>T synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3073983 c.489C>T synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3074046 c.426G>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.44 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.42 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074089 p.Ile128Asn missense_variant 0.4 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074103 c.369C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074121 p.Asp117Glu missense_variant 0.27 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074133 c.339C>T synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAC frameshift_variant&missense_variant 0.27 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074184 c.288A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074196 c.276G>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.4 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074220 c.252A>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074244 c.228A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074252 p.Glu74Gln missense_variant 0.32 para-aminosalicylic_acid
thyA 3074253 p.His73Gln missense_variant 0.32 para-aminosalicylic_acid
thyA 3074256 c.216G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074267 p.Ile69Val missense_variant 0.27 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.27 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087696 c.877_879delACGinsGC frameshift_variant&missense_variant 0.19 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.21 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.22 cycloserine
ald 3087726 p.Ala303Ser missense_variant 0.23 cycloserine
ald 3087729 p.Ser304Ala missense_variant 0.22 cycloserine
ald 3087734 c.915G>C synonymous_variant 0.22 cycloserine
ald 3087737 c.918G>C synonymous_variant 0.22 cycloserine
ald 3087743 c.924G>C synonymous_variant 0.22 cycloserine
fbiD 3339333 c.216G>A synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
Rv3236c 3612643 c.474A>G synonymous_variant 0.18 pyrazinamide
Rv3236c 3612667 c.450T>C synonymous_variant 0.22 pyrazinamide
Rv3236c 3612673 c.444G>A synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
Rv3236c 3612679 c.438G>C synonymous_variant 0.19 pyrazinamide
Rv3236c 3612685 c.432C>T synonymous_variant 0.19 pyrazinamide
Rv3236c 3612694 p.Arg141His missense_variant 0.17 pyrazinamide Uncertain significance
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624134 c.777C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624674 c.237C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624680 c.231T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>A synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.31 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.35 bedaquiline
rifampicin Uncertain significance
lpqB 3624760 c.151C>T synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624779 c.132G>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624783 p.Ser43Thr missense_variant 0.25 bedaquiline
rifampicin
lpqB 3624788 c.123A>G synonymous_variant 0.25 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624812 c.99T>A synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3625027 c.-117C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625032 c.1582C>T synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625057 c.-147C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625060 c.-150G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625095 p.Glu507Gln missense_variant 0.29 bedaquiline
rifampicin
lpqB 3625096 c.-186C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625102 c.-192A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625117 c.1495_1497delCTTinsTG frameshift_variant&synonymous_variant 0.26 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625123 c.-213T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.22 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625669 c.-759G>A upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625693 c.-783G>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625708 c.906C>T synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.36 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625792 c.-882G>A upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625822 c.-912C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625828 c.-918G>A upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625846 c.-936G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625860 p.Ala252Ser missense_variant 0.34 bedaquiline
rifampicin
mtrB 3625864 c.750T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625888 c.-978G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626627 c.-14A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626684 c.-71G>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3626702 c.646_648delCTGinsTA frameshift_variant&synonymous_variant 0.38 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626750 c.-137T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626819 c.-206G>A upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626954 c.-341C>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627113 c.-500C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627122 c.-509T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627175 c.175C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627181 c.-568T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627185 c.163_165delTTGinsCT frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin
mtrA 3627190 c.160T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627197 c.-584T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627233 c.-620T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627239 c.111C>T synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627278 c.-665G>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627287 c.-674C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627296 c.-683T>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCC frameshift_variant&missense_variant 0.26 bedaquiline
rifampicin
fbiB 3641924 c.390A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3641925 p.Thr131Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3641928 c.394T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3641938 p.Gly135Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3641961 p.Thr143Asp missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3641969 c.435C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3641975 c.441C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641987 c.453C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641993 c.459A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
rpoA 3877542 c.966C>T synonymous_variant 0.24 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.35 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.34 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.37 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.32 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.32 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.31 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.33 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.3 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.29 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.35 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>A synonymous_variant 0.34 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.33 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.3 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.29 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.28 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.33 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.31 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.3 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.3 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.29 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.26 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.26 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.27 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.3 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.3 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.33 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.36 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.34 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.34 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.19 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.23 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878355 c.153C>G synonymous_variant 0.32 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.33 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.42 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.47 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.48 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.49 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.46 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.49 rifampicin
rpoA 3878471 p.Val13Ile missense_variant 0.38 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.39 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.31 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.3 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.27 rifampicin
rpoA 3878499 c.9C>T synonymous_variant 0.27 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.26 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878725 c.-220_-218delCTAinsTG upstream_gene_variant 0.22 rifampicin
rpoA 3878728 c.-221G>A upstream_gene_variant 0.21 rifampicin
rpoA 3878734 c.-229_-227delATCinsGG upstream_gene_variant 0.21 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.29 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.35 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.49 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.47 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.46 rifampicin
rpoA 3878837 c.-331_-330delAAinsGG upstream_gene_variant 0.47 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.49 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.44 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.4 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.43 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.43 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.28 rifampicin
rpoA 3878991 c.-484C>A upstream_gene_variant 0.24 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3879006 c.-499A>C upstream_gene_variant 0.2 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.16 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.17 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.26 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879190 c.-683C>T upstream_gene_variant 0.23 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.26 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879238 c.-731C>G upstream_gene_variant 0.21 rifampicin
ddn 3986615 c.-229C>T upstream_gene_variant 0.34 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.34 delamanid
pretomanid
clpC1 4038271 p.Pro812Thr missense_variant 0.23 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038289 p.Asn806Asp missense_variant 0.27 pyrazinamide
clpC1 4038329 p.Glu792Asp missense_variant 0.3 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.32 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.39 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.42 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.53 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.42 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.41 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038692 c.2013C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.42 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.39 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.47 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.39 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.38 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.36 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.37 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039021 c.1684C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039140 p.Glu522Val missense_variant 0.23 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.31 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039238 c.1467C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039268 c.1437C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039274 c.1431G>T synonymous_variant 0.33 pyrazinamide
clpC1 4039277 c.1428C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039319 c.1384_1386delGCTinsAC frameshift_variant&missense_variant 0.3 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.29 pyrazinamide
clpC1 4039328 c.1377A>T synonymous_variant 0.33 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.36 pyrazinamide
clpC1 4039355 c.1350G>T synonymous_variant 0.38 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.27 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039574 c.1129_1131delGCGinsTC frameshift_variant&missense_variant 0.27 pyrazinamide
clpC1 4039589 c.1116G>T synonymous_variant 0.4 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039715 c.990G>A synonymous_variant 0.36 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039727 c.978C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.32 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.41 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039997 c.708C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040021 c.684A>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.38 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040138 c.567G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040234 c.471C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040243 c.462C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.27 pyrazinamide
clpC1 4040288 c.417C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040321 c.384C>T synonymous_variant 0.42 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.27 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040408 c.297C>A synonymous_variant 0.27 pyrazinamide
clpC1 4040411 c.294T>G synonymous_variant 0.24 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040435 c.270G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040456 c.249C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.32 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.37 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040549 c.154_156delTTGinsCT frameshift_variant&missense_variant 0.33 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.34 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040582 c.123G>T synonymous_variant 0.2 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040657 c.48T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040669 c.36C>G synonymous_variant 0.17 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.21 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.21 pyrazinamide
panD 4044201 c.81C>G synonymous_variant 0.21 pyrazinamide
panD 4044796 c.-515G>A upstream_gene_variant 0.18 pyrazinamide
panD 4044797 c.-516C>A upstream_gene_variant 0.18 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.19 pyrazinamide
panD 4044809 c.-528C>G upstream_gene_variant 0.2 pyrazinamide
glpK 4138418 c.1338T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138424 c.1332T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138429 c.1327T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139242 c.514T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139255 c.501G>A synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139258 c.498C>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139261 c.495C>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139270 c.486C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139273 c.483A>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139276 c.480T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139282 c.474T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139285 c.471A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139306 c.450C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239301 c.-562G>C upstream_gene_variant 0.21 ethambutol
embC 4239305 c.-558G>C upstream_gene_variant 0.26 ethambutol
embC 4239311 c.-552G>C upstream_gene_variant 0.31 ethambutol
embC 4239336 c.-527T>C upstream_gene_variant 0.29 ethambutol
embC 4239341 c.-522G>C upstream_gene_variant 0.3 ethambutol
embC 4239378 c.-485T>C upstream_gene_variant 0.31 ethambutol
embC 4240717 c.855T>C synonymous_variant 0.26 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240741 c.879C>T synonymous_variant 0.26 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.3 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.32 ethambutol
embC 4240811 c.949_951delTTCinsCA frameshift_variant&missense_variant 0.3 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.32 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.31 ethambutol
embC 4240837 c.975C>G synonymous_variant 0.31 ethambutol
embC 4240859 c.997_999delCTGinsAA frameshift_variant&missense_variant 0.25 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.26 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.26 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.3 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.31 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.26 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.26 ethambutol
embC 4240918 c.1056G>C synonymous_variant 0.23 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.24 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.26 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.29 ethambutol
embC 4241059 c.1197G>A synonymous_variant 0.32 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.29 ethambutol
embC 4241101 c.1239G>C synonymous_variant 0.33 ethambutol
embC 4241121 p.Ser420Asn missense_variant 0.31 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241567 p.Ile569Val missense_variant 0.2 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.21 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.22 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.24 ethambutol
embC 4241617 c.1755G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241623 c.1761C>A synonymous_variant 0.22 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.24 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.23 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.19 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242805 c.-428G>A upstream_gene_variant 0.18 ethambutol
embA 4242826 c.-407G>C upstream_gene_variant 0.24 ethambutol
embA 4242827 c.-406C>T upstream_gene_variant 0.28 ethambutol
embA 4242832 c.-401A>G upstream_gene_variant 0.31 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.33 ethambutol
embA 4242844 c.-389A>G upstream_gene_variant 0.32 ethambutol
embC 4242847 c.2985C>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embA 4242853 c.-380C>T upstream_gene_variant 0.28 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.33 ethambutol
embA 4242895 c.-338C>T upstream_gene_variant 0.3 ethambutol
embC 4242904 c.3042C>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embA 4242910 c.-323C>T upstream_gene_variant 0.24 ethambutol
embA 4242919 c.-314A>G upstream_gene_variant 0.18 ethambutol
embA 4242925 c.-308C>T upstream_gene_variant 0.17 ethambutol
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244885 c.1653A>G synonymous_variant 0.2 ethambutol
embA 4244886 c.1654C>T synonymous_variant 0.2 ethambutol
embA 4244897 c.1665T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4244900 c.1668G>C synonymous_variant 0.2 ethambutol
embA 4244904 p.Val558Leu missense_variant 0.23 ethambutol Uncertain significance
embA 4244909 c.1677C>G synonymous_variant 0.19 ethambutol
embA 4244916 c.1684C>T synonymous_variant 0.19 ethambutol
embA 4244921 c.1689C>G synonymous_variant 0.17 ethambutol
embA 4245136 p.Tyr635Phe missense_variant 0.24 ethambutol
embB 4245665 c.-849C>G upstream_gene_variant 0.17 ethambutol
embA 4245674 c.2442A>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4245693 c.2461_2463delATCinsGG frameshift_variant&missense_variant 0.28 ethambutol Uncertain significance
embA 4245705 p.His825Asn missense_variant 0.3 ethambutol
embA 4245709 p.Ala826Val missense_variant 0.32 ethambutol
embB 4245713 c.-801G>C upstream_gene_variant 0.31 ethambutol
embB 4245725 c.-789A>C upstream_gene_variant 0.27 ethambutol
embA 4245726 c.2494_2496delTTGinsCC frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
embB 4245737 c.-777A>C upstream_gene_variant 0.27 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.26 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.2 ethambutol
embB 4245845 c.-669T>A upstream_gene_variant 0.16 ethambutol
embB 4245869 c.-645C>G upstream_gene_variant 0.2 ethambutol
embB 4245875 c.-639G>A upstream_gene_variant 0.21 ethambutol
embA 4245885 p.Asp885Thr missense_variant 0.21 ethambutol
embA 4245892 p.Ile887Thr missense_variant 0.19 ethambutol Uncertain significance
embA 4245899 c.2667C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4245905 c.-609C>G upstream_gene_variant 0.18 ethambutol
embB 4247365 c.852A>C synonymous_variant 0.26 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.26 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.3 ethambutol
embB 4247380 c.867C>G synonymous_variant 0.33 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.35 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.34 ethambutol
embB 4247395 c.882C>A synonymous_variant 0.36 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.37 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4247446 c.933C>T synonymous_variant 0.36 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.36 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.31 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.29 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.3 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.28 ethambutol
embB 4247519 c.1006C>T synonymous_variant 0.3 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.3 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.3 ethambutol
embB 4247572 c.1059A>C synonymous_variant 0.3 ethambutol
embB 4247576 c.1063C>T synonymous_variant 0.28 ethambutol
embB 4247579 p.Ala356Ile missense_variant 0.28 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247608 c.1095G>C synonymous_variant 0.33 ethambutol
embB 4247629 c.1116C>G synonymous_variant 0.25 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.22 ethambutol
embB 4247972 p.Thr487Phe missense_variant 0.29 ethambutol
embB 4247977 c.1464C>G synonymous_variant 0.31 ethambutol
embB 4247983 c.1470G>C synonymous_variant 0.3 ethambutol
embB 4247992 c.1479G>A synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.4 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.36 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.36 ethambutol Uncertain significance
embB 4248044 c.1531_1533delAAAinsGC frameshift_variant&missense_variant 0.33 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.4 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.38 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.36 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.3 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.27 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.22 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.21 ethambutol
embB 4248139 c.1626C>A synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.22 ethambutol
embB 4248154 c.1641G>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248161 c.1648C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.29 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.4 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.37 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.43 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.43 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.44 ethambutol
embB 4248328 c.1815G>A synonymous_variant 0.45 ethambutol
embB 4248337 c.1824G>C synonymous_variant 0.43 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.35 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.31 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.3 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Lys missense_variant 0.26 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.28 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.28 ethambutol Uncertain significance
embB 4249432 c.2919A>G synonymous_variant 0.27 ethambutol
embB 4249433 c.2920C>T synonymous_variant 0.27 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.22 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.25 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.3 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.27 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.27 ethambutol
embB 4249492 c.2979C>A synonymous_variant 0.27 ethambutol
aftB 4267647 p.Asp397Cys missense_variant 0.76 ethambutol
aftB 4267655 c.1182C>G synonymous_variant 0.22 ethambutol
aftB 4268105 c.732T>C synonymous_variant 0.2 ethambutol
aftB 4268120 c.717C>G synonymous_variant 0.22 ethambutol
aftB 4268123 c.712_714delAGTinsGG frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
aftB 4268126 c.711G>C synonymous_variant 0.21 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.22 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.22 ethambutol
aftB 4269210 c.-374G>A upstream_gene_variant 0.17 ethambutol
aftB 4269225 c.-389C>A upstream_gene_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R