TB-Profiler result

Run: ERR2041725
Summary

Run ID: ERR2041725

Sample name:

Date: 2024-04-14T16:07:10.536672

Number of reads: 1078421

Percentage reads mapped: 64.28

Median coverage: 46.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.99
lineage4 Euro-American None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.His445Asp Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Gly406Ser Assoc w R
p.Asp1024Asn Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.766_768delGCTinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.751_753delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.820_822delTTAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2344_2346delTCGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491548 c.766_768delGCTinsCC frameshift_variant&missense_variant 0.32 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761139 p.His445Asp missense_variant 0.51 rifampicin Assoc w R
fbiC 1303681 c.751_753delTTGinsCC frameshift_variant&missense_variant 0.27 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303750 c.820_822delTTAinsGG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305274 c.2344_2346delTCGinsCC frameshift_variant&missense_variant 0.25 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247729 p.Gly406Ser missense_variant 0.93 ethambutol Assoc w R
embB 4249583 p.Asp1024Asn missense_variant 1.0 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 779 p.Arg260His missense_variant 1.0 isoniazid Uncertain significance
gyrB 7060 c.1821T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7502 c.201C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8366 c.1065G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8507 c.1206C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8547 p.Ile416Val missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8548 c.1247_1248insGGCA frameshift_variant 0.25 levofloxacin
moxifloxacin
gyrA 8553 c.1252C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8557 c.1258_1261delGGAC frameshift_variant 0.25 levofloxacin
moxifloxacin
gyrA 8568 p.Glu423Ser missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8573 c.1272G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8585 c.1284C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8600 c.1299G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8649 p.Arg450Lys missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8708 c.1407G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480Gln missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8742 c.1441_1443delGACinsCG frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8769 p.His490Tyr missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8822 c.1521C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8882 c.1581G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8981 c.1680G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9020 c.1719G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9063 p.Ser588Leu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 c.2007C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9311 c.2010C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
fgd1 491259 c.477T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491262 c.480C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491307 c.525C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491320 p.Ala180Thr missense_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>A synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.54 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491382 c.600G>A synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491415 c.633A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491418 c.636A>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491424 c.642C>T synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491427 c.645C>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491430 c.648T>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491436 c.654T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491439 p.Asp219Glu missense_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491443 p.Ser221Asp missense_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491454 c.672C>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491493 c.711C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491503 c.721C>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491591 p.Lys270Met missense_variant 0.71 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
fgd1 491601 c.819T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
mshA 575659 c.312A>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.21 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575679 p.Asn111Ser missense_variant 0.76 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575689 c.342G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575692 c.345G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.29 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575714 p.Tyr123Asn missense_variant 0.3 ethionamide
isoniazid
mshA 575732 c.385_387delCTTinsTG frameshift_variant&missense_variant 0.29 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575737 c.390T>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575795 c.448_450delATCinsGG frameshift_variant&missense_variant 0.25 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575803 c.456C>T synonymous_variant 0.27 ethionamide
isoniazid Not assoc w R - Interim
mshA 575812 c.465C>T synonymous_variant 0.22 ethionamide
isoniazid
mshA 575818 c.471G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575824 c.477T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575843 p.Arg166Ala missense_variant 0.26 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575892 p.Ala182Gly missense_variant 0.21 ethionamide
isoniazid
mshA 575908 c.561A>C synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
nusG 734439 c.186C>G synonymous_variant 0.23 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.25 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.25 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.25 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.25 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.29 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.27 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.88 rifampicin Not assoc w R
rpoB 760181 c.375T>G synonymous_variant 0.19 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.19 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.29 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.3 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.29 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.3 rifampicin
rpoB 760334 c.528G>C synonymous_variant 0.28 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.27 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.27 rifampicin
rpoB 760354 p.Glu183Ala missense_variant 0.33 rifampicin
rpoB 760357 p.Thr184Asn missense_variant 0.33 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.34 rifampicin Uncertain significance
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.3 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.3 rifampicin Uncertain significance
rpoB 760418 c.612G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760448 c.642C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760449 p.Thr215Leu missense_variant 0.23 rifampicin
rpoB 760460 c.654G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>G synonymous_variant 0.23 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760527 p.Gln241Ala missense_variant 0.28 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Arg missense_variant 0.26 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.33 rifampicin Uncertain significance
rpoB 760587 p.Thr261Ala missense_variant 0.3 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.31 rifampicin
rpoB 760593 p.Gly263Asn missense_variant 0.31 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760643 c.837G>A synonymous_variant 0.27 rifampicin
rpoB 760649 c.843G>C synonymous_variant 0.26 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760965 c.1159_1161delATGinsCC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 0.31 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.33 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.42 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.47 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.47 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.47 rifampicin
rpoB 761133 c.1327T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.45 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.44 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.4 rifampicin
rpoB 761195 c.1389G>T synonymous_variant 0.38 rifampicin
rpoB 761201 c.1395G>A synonymous_variant 0.36 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.37 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.37 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.37 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.38 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.4 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.44 rifampicin
rpoB 761346 p.Val514Asn missense_variant 0.42 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.46 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761369 p.Glu521Asp missense_variant 0.41 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.4 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.4 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.39 rifampicin
rpoB 761430 c.1624_1626delATCinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoB 761435 p.Asp543Glu missense_variant 0.38 rifampicin
rpoB 761437 p.Ala544Asp missense_variant 0.38 rifampicin
rpoB 761451 p.Val549Thr missense_variant 0.36 rifampicin
rpoB 761457 p.Pro551Glu missense_variant 0.38 rifampicin
rpoB 761477 c.1671C>T synonymous_variant 0.34 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.34 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.36 rifampicin
rpoB 761502 c.1696_1698delCCCinsTG frameshift_variant&missense_variant 0.37 rifampicin
rpoB 761508 c.1702_1704delTCTinsGC frameshift_variant&missense_variant 0.35 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.35 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.43 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761640 c.1834C>T synonymous_variant 0.39 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.38 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.39 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.4 rifampicin
rpoB 761687 c.1881C>G synonymous_variant 0.4 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.38 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.34 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.31 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.3 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761747 c.1941G>C synonymous_variant 0.32 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.31 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.34 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.34 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.36 rifampicin
rpoB 761790 p.Arg662Ala missense_variant 0.36 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.32 rifampicin
rpoB 761814 p.Ala670Asn missense_variant 0.31 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.31 rifampicin
rpoB 761847 c.2041_2043delTGCinsCG frameshift_variant&missense_variant 0.27 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.27 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.28 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>T synonymous_variant 0.29 rifampicin
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 0.29 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.31 rifampicin
rpoB 761892 p.Ile696Val missense_variant 0.34 rifampicin
rpoB 761897 c.2091C>G synonymous_variant 0.36 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.36 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.33 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.34 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.35 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.35 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAG frameshift_variant&missense_variant 0.41 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.39 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.4 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.39 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.38 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.38 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.37 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.38 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>T synonymous_variant 0.37 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.38 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762281 c.2475G>A synonymous_variant 0.39 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.39 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.38 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.35 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.36 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.36 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.37 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.37 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.35 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.4 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Ala missense_variant 0.36 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.3 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.3 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.28 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.2 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.2 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.21 rifampicin
rpoC 762557 c.-813G>C upstream_gene_variant 0.18 rifampicin
rpoB 762812 c.3006C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762814 p.Met1003Lys missense_variant 0.2 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762894 c.3088C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762902 c.-468C>T upstream_gene_variant 0.37 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762962 c.-408C>A upstream_gene_variant 0.4 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.42 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.42 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763049 c.-321G>A upstream_gene_variant 0.43 rifampicin
rpoC 763058 c.-312C>G upstream_gene_variant 0.41 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.32 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.32 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.33 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.36 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.39 rifampicin
rpoC 763178 c.-192G>A upstream_gene_variant 0.38 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.31 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.32 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.31 rifampicin Uncertain significance
rpoB 763214 c.3408T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.35 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763262 c.-108C>A upstream_gene_variant 0.27 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.27 rifampicin
rpoB 763283 c.3477T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763304 c.-66A>C upstream_gene_variant 0.2 rifampicin
rpoC 763305 c.-65_-63delAGTinsTCC upstream_gene_variant 0.18 rifampicin
rpoC 763310 c.-60C>T upstream_gene_variant 0.18 rifampicin
rpoC 763313 c.-57G>A upstream_gene_variant 0.18 rifampicin
rpoB 763317 p.Leu1171Phe missense_variant 0.17 rifampicin
rpoC 763330 c.-40G>T upstream_gene_variant 0.18 rifampicin
rpoC 763333 c.-36_-33delCAAA upstream_gene_variant 0.19 rifampicin
rpoC 763339 c.-31_-30insTTC upstream_gene_variant 0.19 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoC 763396 c.27A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763409 c.40_42delCTTinsTG frameshift_variant&missense_variant 0.34 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.34 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763561 c.192G>A synonymous_variant 0.47 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>A synonymous_variant 0.36 rifampicin
rpoC 763705 c.336G>C synonymous_variant 0.38 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.4 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.41 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.43 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.44 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.42 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.4 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.37 rifampicin
rpoC 763781 c.412_414delTCGinsAGC synonymous_variant 0.32 rifampicin
rpoC 763790 p.Glu141Thr missense_variant 0.3 rifampicin
rpoC 763801 c.432C>T synonymous_variant 0.27 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.28 rifampicin
rpoC 763822 c.453C>G synonymous_variant 0.27 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763831 c.462A>G synonymous_variant 0.25 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.25 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.25 rifampicin
rpoC 763844 p.Arg159Lys missense_variant 0.25 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.27 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.28 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.31 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.31 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.32 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.3 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.31 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.31 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.31 rifampicin Uncertain significance
rpoC 763978 c.609C>T synonymous_variant 0.25 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.2 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.22 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.29 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.26 rifampicin
rpoC 764030 p.Asp221Asn missense_variant 0.26 rifampicin Uncertain significance
rpoC 764039 p.Ser224Asp missense_variant 0.26 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.27 rifampicin
rpoC 764048 p.Thr227Val missense_variant 0.27 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.29 rifampicin
rpoC 764080 c.711C>T synonymous_variant 0.32 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.33 rifampicin
rpoC 764085 p.Asn239Thr missense_variant 0.33 rifampicin Uncertain significance
rpoC 764087 p.Leu240Val missense_variant 0.33 rifampicin Uncertain significance
rpoC 764095 c.726C>G synonymous_variant 0.37 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764134 c.765C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764161 c.792G>C synonymous_variant 0.48 rifampicin
rpoC 764169 p.Asn267Thr missense_variant 0.49 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.46 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Thr missense_variant 0.45 rifampicin Uncertain significance
rpoC 764213 p.Arg282Lys missense_variant 0.46 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.49 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.49 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.5 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.5 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.48 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.46 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.48 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.41 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.41 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.38 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.37 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.37 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.38 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.35 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764515 c.1146C>T synonymous_variant 0.33 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764551 c.1182G>C synonymous_variant 0.29 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.25 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.37 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.46 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.46 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.42 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.42 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.36 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765031 c.1662G>A synonymous_variant 0.3 rifampicin
rpoC 765034 c.1665T>C synonymous_variant 0.3 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>T synonymous_variant 0.3 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.31 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765121 c.1752G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765277 c.1908G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765281 p.Thr638Asp missense_variant 0.18 rifampicin Uncertain significance
rpoC 765300 p.Val644Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 765305 c.1936_1938delATCinsGG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 765311 p.Ala648Thr missense_variant 0.2 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765326 c.1957_1959delCACinsGG frameshift_variant&missense_variant 0.19 rifampicin
rpoC 765330 p.Ser654Asn missense_variant 0.19 rifampicin Uncertain significance
rpoC 765339 p.Gln657Arg missense_variant 0.19 rifampicin Uncertain significance
rpoC 765343 c.1974G>C synonymous_variant 0.19 rifampicin
rpoC 765346 c.1977C>T synonymous_variant 0.19 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765359 p.Ala664Thr missense_variant 0.2 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.23 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.23 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.28 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.28 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.33 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.48 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.49 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.49 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.5 rifampicin
rpoC 765607 c.2238C>G synonymous_variant 0.49 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.48 rifampicin Uncertain significance
rpoC 765628 c.2259G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.52 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765718 p.Asp783Glu missense_variant 0.5 rifampicin Uncertain significance
rpoC 765724 c.2355C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.51 rifampicin
rpoC 765742 p.Glu791Asp missense_variant 0.5 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.5 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.5 rifampicin Uncertain significance
rpoC 765790 c.2421C>G synonymous_variant 0.47 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.47 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.46 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.51 rifampicin Uncertain significance
rpoC 765884 c.2515_2516delTCinsAG synonymous_variant 0.51 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.45 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765991 c.2622C>G synonymous_variant 0.26 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.2 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.22 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.23 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.23 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.24 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.34 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.35 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.32 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.31 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.31 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.28 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.29 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.28 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.28 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.27 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.27 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.28 rifampicin
rpoC 766607 c.3238_3240delATCinsTG frameshift_variant&missense_variant 0.27 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.28 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.29 rifampicin
rpoC 766642 c.3273C>T synonymous_variant 0.26 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.21 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.21 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.23 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.22 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.24 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.24 rifampicin
rpoC 766693 c.3324C>A synonymous_variant 0.25 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.25 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.24 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.25 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.24 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.26 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.24 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.24 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.24 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.27 rifampicin Uncertain significance
rpoC 766843 c.3474T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.47 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.47 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.46 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.45 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.45 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.45 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.46 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.48 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.48 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>G synonymous_variant 0.5 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>C synonymous_variant 0.49 rifampicin
rpoC 767059 c.3690T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.45 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>G synonymous_variant 0.37 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.3 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767266 c.3897G>C synonymous_variant 0.24 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.21 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.19 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781276 c.-284A>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781664 c.105C>T synonymous_variant 0.16 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.23 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.25 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.24 streptomycin
rpsL 781726 p.Lys56Arg missense_variant 0.25 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.26 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.26 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.25 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.25 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.25 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.27 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.27 streptomycin
rpsL 781784 c.225G>A synonymous_variant 0.29 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.32 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.32 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.34 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.36 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.35 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.36 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.35 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.36 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.34 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.35 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.34 streptomycin Uncertain significance
rplC 801009 c.201A>C synonymous_variant 0.21 linezolid
rplC 801019 p.Thr71Ala missense_variant 0.22 linezolid
rplC 801030 c.222C>G synonymous_variant 0.21 linezolid
rplC 801039 c.231A>G synonymous_variant 0.2 linezolid
rplC 801045 c.237A>G synonymous_variant 0.18 linezolid
rplC 801046 p.Tyr80His missense_variant 0.18 linezolid
rplC 801054 c.246G>C synonymous_variant 0.18 linezolid
rplC 801058 c.250C>T synonymous_variant 0.18 linezolid
rplC 801066 c.258G>T synonymous_variant 0.18 linezolid
rplC 801176 p.Phe123Tyr missense_variant 0.16 linezolid
fbiC 1303545 c.615A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303582 p.Thr218Ala missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303613 p.Leu228Gln missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303629 c.699C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303666 p.Thr246Ala missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303680 c.750G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303689 c.759T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303768 p.Ser280Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305173 p.Asn748Ser missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305177 c.2247A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305181 c.2251T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305213 c.2283C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305216 c.2286C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305219 c.2289T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>T synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305237 c.2307A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305249 c.2319G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305259 c.2329T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305267 c.2337C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305277 p.His783Asn missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305348 c.2418C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305360 c.2430G>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472302 n.457_458insT non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472310 n.465_466insG non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473792 n.135C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473793 n.136G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473802 n.145C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474026 n.369C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474094 n.437C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474105 n.448delTinsCG non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630_631insTC non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474293 n.637_646delCCTCTCCGGA non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474306 n.649A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474421 n.764G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474430 n.773delCinsTTG non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474432 n.775C>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474438 n.781A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474711 n.1054G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474715 n.1058_1059insC non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474952 n.1296delC non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474957 n.1301_1308delACCTTGTG non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474969 n.1312_1315delGGTGinsAGGAT non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474990 n.1333C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474991 n.1334T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474995 n.1338T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474997 n.1340A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474999 n.1342C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475008 n.1351C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475010 n.1353G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475015 n.1358_1360delCCGinsTCTA non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475382 n.1725A>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475407 n.1750C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475428 n.1771G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475433 n.1776A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475614 n.1957A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105delGinsCTT non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475764 n.2107A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid Uncertain significance
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036delGinsCA non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
inhA 1674624 c.423A>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.25 ethionamide
isoniazid
rpsA 1833547 c.6G>A synonymous_variant 0.27 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.29 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.28 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.28 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.31 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.31 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1833664 c.123C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.44 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.45 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.44 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.45 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.44 pyrazinamide
rpsA 1833796 c.255G>A synonymous_variant 0.43 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.43 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.4 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.4 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834039 c.498C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.31 pyrazinamide
rpsA 1834094 c.553C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.35 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.37 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.38 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.37 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.41 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.43 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.43 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834525 c.984G>A synonymous_variant 0.43 pyrazinamide
rpsA 1834527 p.Arg329Gln missense_variant 0.43 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834564 c.1023C>T synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834579 c.1038C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.38 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.37 pyrazinamide
rpsA 1834627 c.1086C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.42 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834759 c.1218A>T synonymous_variant 0.32 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.32 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.31 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.22 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsAC upstream_gene_variant 0.21 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.19 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.19 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.19 linezolid
tsnR 1853401 c.-205A>G upstream_gene_variant 0.18 linezolid
tsnR 1853403 c.-203A>G upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102401 c.642T>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102407 c.636T>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102416 c.627G>A synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102436 p.His203Asn missense_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102437 c.606G>C synonymous_variant 0.19 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102443 c.600A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.27 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.24 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.22 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.25 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.26 isoniazid
kasA 2518570 c.456G>A synonymous_variant 0.25 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.26 isoniazid
kasA 2518579 c.465T>G synonymous_variant 0.24 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.27 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.27 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.33 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.36 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.37 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.39 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.39 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.36 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.36 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.36 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.38 isoniazid
kasA 2518739 p.Ala209Thr missense_variant 0.38 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.33 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.33 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.33 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.27 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.28 isoniazid
kasA 2518787 c.673_675delCGGinsGC frameshift_variant&missense_variant 0.27 isoniazid
kasA 2518816 c.702C>G synonymous_variant 0.25 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.23 isoniazid
Rv2477c 2782570 c.1473C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782612 c.1431T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782615 c.1428G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782668 p.Gln459Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782675 c.1368G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782690 c.1353C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782695 c.1348A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782702 c.1341G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782862 p.Ala394Val missense_variant 0.9 ethambutol Uncertain significance
moxifloxacin
streptomycin Uncertain significance
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2782876 c.1167G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782924 c.1119G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782928 p.Thr372Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782963 c.1080G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782981 c.1062G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782987 c.1056C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783014 p.Ser343Thr missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783084 p.Val320Gln missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783087 p.Asn319Ser missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783105 p.Val313Thr missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783134 c.909G>A synonymous_variant 0.33 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.32 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 p.Ala295Val missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783192 p.Ser284Asn missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783206 c.837G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783218 c.825C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 p.Gln255Ala missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783407 c.636C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783444 p.Gln200Ser missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783449 c.594C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783506 c.537C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783523 c.520C>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTT frameshift_variant&missense_variant 0.37 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783634 p.Leu137Ile missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783646 p.Asp133Asn missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783692 c.351G>A synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783728 c.315G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783764 c.277_279delATGinsCC frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783773 c.270A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783788 c.255T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783791 c.252C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783824 c.219G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783837 p.Thr69Ser missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783845 c.196_198delACCinsCG frameshift_variant&synonymous_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783848 c.193_195delGCCinsTT frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783857 c.186C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783866 c.177C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783872 c.171G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 p.Lys56Thr missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783935 c.108C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065712 c.480C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065727 c.465C>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067244 c.702C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074495 c.-24C>T upstream_gene_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3625060 c.-150G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625069 c.-159T>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625075 c.-165G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625095 p.Glu507Lys missense_variant 0.23 bedaquiline
rifampicin
lpqB 3625111 c.-201G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.25 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625141 c.-231T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625150 c.-240C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625162 c.-252T>G upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625177 c.-267C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625204 c.1408_1410delTCGinsGC frameshift_variant&missense_variant 0.28 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625222 c.1392T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.2 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625585 c.-675G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625599 p.Met339Leu missense_variant 0.33 bedaquiline
rifampicin Uncertain significance
lpqB 3625602 c.-692T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ser missense_variant 0.35 bedaquiline
rifampicin
mtrB 3625627 p.Asp329Glu missense_variant 0.34 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625636 p.Ala326Glu missense_variant 0.36 bedaquiline
rifampicin
mtrB 3625645 c.969C>T synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.37 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.41 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.46 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625819 c.795G>A synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626776 c.-163A>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626804 c.-191A>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626816 c.-203G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3626822 p.Asp176Glu missense_variant 0.35 bedaquiline
rifampicin
mtrB 3626825 c.-212T>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626843 c.-230G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3626907 p.Asn148Gly missense_variant 0.45 bedaquiline
rifampicin
mtrA 3626912 p.Thr146Ser missense_variant 0.43 bedaquiline
rifampicin
mtrB 3626924 c.-311G>A upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.45 bedaquiline
rifampicin
mtrA 3626942 c.406_408delGTAinsAC frameshift_variant&missense_variant 0.45 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626999 c.-386G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627011 c.-398T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627053 c.297C>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627056 c.294C>T synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627068 c.282T>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3627131 p.Ala73Lys missense_variant 0.4 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.46 bedaquiline
rifampicin
mtrB 3627194 c.-581G>A upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrA 3627213 p.Arg46His missense_variant 0.48 bedaquiline
rifampicin
mtrB 3627224 c.-611G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrA 3627247 p.Ile35Val missense_variant 0.51 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627272 c.-659G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627323 c.25_27delTTGinsCC frameshift_variant&missense_variant 0.36 bedaquiline
rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.17 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.2 rifampicin
rpoA 3877611 c.895_897delATCinsGG frameshift_variant&missense_variant 0.24 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.25 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.26 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.29 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 0.28 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.27 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.34 rifampicin
rpoA 3877815 c.693C>A synonymous_variant 0.33 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.33 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.32 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.36 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.35 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.36 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.34 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.3 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.3 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.25 rifampicin
rpoA 3878013 c.495T>C synonymous_variant 0.25 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.24 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.24 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.24 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.24 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.24 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.25 rifampicin
rpoA 3878046 p.Ala154Val missense_variant 0.26 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.25 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.26 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.3 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.3 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878093 p.Val139Ile missense_variant 0.34 rifampicin
rpoA 3878094 c.412_414delCTCinsTG frameshift_variant&synonymous_variant 0.34 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.36 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.36 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.37 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.39 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.39 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.39 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.41 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.4 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878166 c.342C>G synonymous_variant 0.41 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.4 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878244 p.Glu88Asp missense_variant 0.48 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.49 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.49 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.47 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.44 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.47 rifampicin
rpoA 3878304 c.204G>C synonymous_variant 0.46 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.44 rifampicin
rpoA 3878316 c.192C>G synonymous_variant 0.45 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.48 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.47 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.45 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.46 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.43 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.43 rifampicin
rpoA 3878394 c.114G>T synonymous_variant 0.43 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.38 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.33 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.29 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.4 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.39 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878758 c.-251G>C upstream_gene_variant 0.39 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.36 rifampicin
rpoA 3878775 c.-268A>G upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878782 c.-275G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.36 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.34 rifampicin
rpoA 3878808 c.-301G>T upstream_gene_variant 0.36 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.38 rifampicin
rpoA 3878830 c.-325_-323delCTGinsAC upstream_gene_variant 0.34 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.34 rifampicin
rpoA 3878843 c.-337_-336delCGinsAA upstream_gene_variant 0.34 rifampicin
rpoA 3878845 c.-338G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.35 rifampicin
rpoA 3878869 c.-362G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878873 c.-366G>A upstream_gene_variant 0.31 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.34 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.33 rifampicin
rpoA 3878899 c.-392C>T upstream_gene_variant 0.3 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.31 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878931 c.-424C>T upstream_gene_variant 0.24 rifampicin
rpoA 3878935 c.-428C>T upstream_gene_variant 0.24 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878947 c.-440G>T upstream_gene_variant 0.23 rifampicin
rpoA 3878950 c.-443C>T upstream_gene_variant 0.23 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.23 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.22 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.21 delamanid
pretomanid
clpC1 4038356 c.2349T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038395 c.2310C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038436 p.Ala757Ser missense_variant 0.31 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.31 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038451 p.Thr752Ser missense_variant 0.3 pyrazinamide
clpC1 4038455 c.2246_2249delTGGT frameshift_variant 0.29 pyrazinamide
clpC1 4038462 c.2242_2243insACAT frameshift_variant 0.29 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.3 pyrazinamide
clpC1 4038485 p.Gly740Lys missense_variant 0.32 pyrazinamide
clpC1 4038491 c.2214C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.34 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.35 pyrazinamide
clpC1 4038512 c.2193C>G synonymous_variant 0.35 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.38 pyrazinamide
clpC1 4038530 c.2175G>A synonymous_variant 0.34 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.33 pyrazinamide
clpC1 4038538 p.Thr723Ser missense_variant 0.33 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.45 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.45 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.47 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.47 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.47 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.47 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.49 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.52 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>T synonymous_variant 0.56 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.5 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.54 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4038794 c.1909_1911delAGCinsTCG synonymous_variant 0.44 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.42 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.42 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038917 c.1788C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.4 pyrazinamide
clpC1 4038929 c.1776G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.51 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.44 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.41 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039067 c.1638G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.4 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.39 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039141 p.Glu522Lys missense_variant 0.36 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.32 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039199 c.1506C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039265 c.1440C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039292 c.1413C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039295 c.1408_1410delTCAinsGC frameshift_variant&missense_variant 0.3 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.33 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.36 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.35 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039355 c.1350G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.4 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.38 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.38 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039442 c.1261_1263delCTAinsTG frameshift_variant&synonymous_variant 0.37 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039481 c.1224T>A synonymous_variant 0.39 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.45 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Ser missense_variant 0.43 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039581 p.Thr375Ser missense_variant 0.43 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039766 c.939T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039781 c.924G>T synonymous_variant 0.33 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.38 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040001 p.His235Ala missense_variant 0.43 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.4 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.42 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040135 c.570C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040165 c.540G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.4 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.43 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.44 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.49 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.57 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.6 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.55 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.56 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.51 pyrazinamide
clpC1 4040326 c.379C>T synonymous_variant 0.54 pyrazinamide
clpC1 4040342 c.363C>A synonymous_variant 0.47 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.46 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.46 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.41 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.41 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040419 c.286C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040432 c.273C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040444 c.261C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.36 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.36 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.34 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.35 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.34 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040596 c.109C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040597 c.108C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCC frameshift_variant&missense_variant 0.35 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.35 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.36 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.33 pyrazinamide
clpC1 4040645 c.60C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
glpK 4138598 c.1158G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138726 p.Ala344Thr missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4241084 p.Leu408Ala missense_variant 0.19 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>A synonymous_variant 0.18 ethambutol
embC 4241134 c.1272G>A synonymous_variant 0.2 ethambutol
embC 4241135 p.Val425Leu missense_variant 0.2 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.18 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.96 ethambutol Not assoc w R
embA 4244288 c.1056C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244858 c.1626G>C synonymous_variant 0.35 ethambutol
embA 4244862 p.Leu544Val missense_variant 0.33 ethambutol
embA 4244873 c.1641C>G synonymous_variant 0.38 ethambutol
embA 4244876 c.1644G>C synonymous_variant 0.39 ethambutol
embA 4244885 c.1653A>G synonymous_variant 0.43 ethambutol
embA 4244894 c.1662C>G synonymous_variant 0.41 ethambutol
embA 4244897 c.1665T>G synonymous_variant 0.41 ethambutol
embA 4244906 c.1674C>G synonymous_variant 0.41 ethambutol
embA 4244909 c.1677C>A synonymous_variant 0.38 ethambutol
embA 4244919 c.1687_1689delCTCinsTG frameshift_variant&missense_variant 0.37 ethambutol Uncertain significance
embA 4244930 c.1698G>C synonymous_variant 0.43 ethambutol
embA 4244933 c.1701A>G synonymous_variant 0.46 ethambutol
embA 4244945 c.1713C>G synonymous_variant 0.47 ethambutol
embA 4244959 p.Ala576Gly missense_variant 0.46 ethambutol
embA 4244980 p.Val583Ala missense_variant 0.43 ethambutol
embA 4244982 c.1750T>C synonymous_variant 0.4 ethambutol
embA 4244986 p.Gly585Ala missense_variant 0.41 ethambutol
embA 4244999 c.1767G>C synonymous_variant 0.38 ethambutol
embA 4245008 c.1776T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embA 4245015 p.Ile595Val missense_variant 0.35 ethambutol Uncertain significance
embA 4245020 c.1788T>G synonymous_variant 0.3 ethambutol
embA 4245023 c.1791A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embA 4245026 c.1794T>C synonymous_variant 0.27 ethambutol
embA 4245029 c.1797T>C synonymous_variant 0.27 ethambutol
embA 4245039 c.1807_1809delCTCinsAG frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
embA 4245050 c.1818C>T synonymous_variant 0.21 ethambutol
embB 4248173 p.Val554Met missense_variant 0.17 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.2 ethambutol
embB 4248202 c.1689T>C synonymous_variant 0.2 ethambutol
embB 4248203 p.Pro564Ala missense_variant 0.2 ethambutol
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.2 ethambutol
embB 4248215 p.Arg568Ser missense_variant 0.22 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.22 ethambutol Uncertain significance
embB 4248248 c.1735_1737delTTCinsCG frameshift_variant&missense_variant 0.21 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.2 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.23 ethambutol
embB 4248264 p.Phe584Ser missense_variant 0.23 ethambutol
embB 4248274 c.1761C>T synonymous_variant 0.24 ethambutol
embB 4248275 c.1762_1764delACGinsGC frameshift_variant&missense_variant 0.23 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.27 ethambutol
embB 4248319 c.1806A>C synonymous_variant 0.27 ethambutol
embB 4248321 p.Gly603Ala missense_variant 0.26 ethambutol Uncertain significance
embB 4248324 p.Ala604Gly missense_variant 0.27 ethambutol
embB 4248338 c.1825C>T synonymous_variant 0.29 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.29 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.27 ethambutol
embB 4248368 p.Leu619Val missense_variant 0.22 ethambutol
embB 4248382 c.1869C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
ethA 4326788 p.Leu229Arg missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407979 p.Pro75Leu missense_variant 1.0 streptomycin Uncertain significance