TB-Profiler result

Run: SRR5341315
Summary

Run ID: SRR5341315

Sample name:

Date: 2024-04-15T08:11:11.122445

Number of reads: 590169

Percentage reads mapped: 9.01

Median coverage: 6.0

Strain: La1.7;lineage3;lineage4.9;lineage7

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.13
La1.7 M.bovis None 0.05
lineage4 Euro-American None 0.71
lineage4.9 Euro-American (H37Rv-like) None 0.55
lineage7 Lineage 7 None 0.1
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.859_861delGCGinsTA Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.601_603delATGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1189_1191delAAAinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491641 c.859_861delGCGinsTA frameshift_variant&stop_gained 0.85 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303531 c.601_603delATGinsCC frameshift_variant&missense_variant 0.81 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304119 c.1189_1191delAAAinsCG frameshift_variant&missense_variant 0.69 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.8 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 705 c.705A>G synonymous_variant 0.54 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.54 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.54 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.67 isoniazid Not assoc w R - Interim
dnaA 1110 c.1110T>C synonymous_variant 0.63 isoniazid
dnaA 1134 c.1134G>T synonymous_variant 0.57 isoniazid
gyrB 6091 c.852G>T synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrB 6097 c.858G>A synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrB 6100 c.861G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrB 6110 p.Met291Leu missense_variant 0.88 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.98 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6181 c.942C>T synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrB 6205 p.Ser322Arg missense_variant 0.81 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.91 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrA 6367 c.-935C>T upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrB 6398 p.Val387Ile missense_variant 0.96 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.88 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.79 levofloxacin
moxifloxacin
gyrB 6417 p.Thr393Ser missense_variant 0.73 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6655 c.-647T>C upstream_gene_variant 0.89 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.87 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>C upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.81 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.81 levofloxacin
moxifloxacin
gyrB 6802 c.1563G>A synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.87 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7391 c.90C>T synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7422 c.121C>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.82 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7514 c.213C>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7526 c.225G>A synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.9 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.74 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7775 c.474C>G synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8201 c.900C>G synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8213 c.912C>T synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8237 c.936A>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.72 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.84 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8354 c.1053G>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8372 c.1071G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 p.Asp367Asn missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8432 c.1131C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8547 c.1246_1248delATCinsGG frameshift_variant&missense_variant 0.86 levofloxacin
moxifloxacin
gyrA 8555 c.1254G>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8597 c.1296C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8609 c.1308G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8612 c.1311C>T synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8630 c.1329G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8723 c.1422G>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>T synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8924 c.1623C>T synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8945 c.1644G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.87 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.89 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9014 c.1713C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 9113 c.1812C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 9398 c.2097T>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 9419 c.2118T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Glu missense_variant 0.65 levofloxacin
moxifloxacin
gyrA 9425 p.Asp708Glu missense_variant 0.62 levofloxacin
moxifloxacin
gyrA 9431 c.2130G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9449 c.2148C>G synonymous_variant 0.62 levofloxacin
moxifloxacin
fgd1 491094 c.312C>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491127 c.345C>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491168 p.Phe129Tyr missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491569 p.Asp263Asn missense_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491577 c.795G>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491599 p.Asp273Asn missense_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.77 clofazimine
pretomanid
delamanid
mshA 575803 c.456C>T synonymous_variant 0.74 ethionamide
isoniazid Not assoc w R - Interim
mshA 575833 c.486C>T synonymous_variant 0.72 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575842 c.495G>A synonymous_variant 0.72 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.72 ethionamide
isoniazid
mshA 575848 c.501C>T synonymous_variant 0.7 ethionamide
isoniazid
mshA 575851 c.504C>G synonymous_variant 0.68 ethionamide
isoniazid
mshA 575864 c.517_519delTTGinsCC frameshift_variant&missense_variant 0.68 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575875 c.528C>G synonymous_variant 0.54 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.48 ethionamide
isoniazid
mshA 575939 c.592C>T synonymous_variant 0.84 ethionamide
isoniazid
mshA 575945 p.Thr200Ala missense_variant 0.84 ethionamide
isoniazid
mshA 575953 c.606G>A synonymous_variant 0.83 ethionamide
isoniazid
mshA 575956 c.609G>A synonymous_variant 0.83 ethionamide
isoniazid
mshA 575959 c.612G>A synonymous_variant 0.79 ethionamide
isoniazid
mshA 575965 c.618C>G synonymous_variant 0.83 ethionamide
isoniazid Not assoc w R - Interim
mshA 575980 c.633T>C synonymous_variant 0.74 ethionamide
isoniazid
ccsA 619601 c.-290G>A upstream_gene_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 619607 c.-284C>G upstream_gene_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 619615 c.-276C>G upstream_gene_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 619618 c.-273C>G upstream_gene_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 619629 c.-262G>C upstream_gene_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257_-256delTCinsAT upstream_gene_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 619648 c.-243C>G upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620187 c.297C>T synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620197 p.Gln103Ser missense_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620241 c.351C>G synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.85 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.78 capreomycin
amikacin
kanamycin
ccsA 620754 c.864G>C synonymous_variant 0.9 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.89 capreomycin
amikacin
kanamycin
ccsA 620791 c.901_903delGTGinsAC frameshift_variant&missense_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620802 c.912C>G synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620808 c.918T>C synonymous_variant 0.71 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620818 c.928_930delGTTinsAC frameshift_variant&missense_variant 0.61 capreomycin
amikacin
kanamycin
ccsA 620829 c.939G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
Rv0565c 657640 c.-170A>T upstream_gene_variant 0.7 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.76 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.94 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.91 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.91 ethionamide
Rv0565c 657703 c.-233C>A upstream_gene_variant 0.91 ethionamide
Rv0565c 657724 c.-254A>C upstream_gene_variant 0.85 ethionamide
Rv0565c 657729 c.-259G>C upstream_gene_variant 0.87 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.82 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.72 isoniazid
hadA 731738 c.-192G>C upstream_gene_variant 0.8 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.93 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.94 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.97 isoniazid
hadA 731786 c.-144C>G upstream_gene_variant 0.98 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.98 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.94 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.81 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.75 isoniazid
hadA 732284 c.355_357delCAGinsGC frameshift_variant&missense_variant 0.75 isoniazid Uncertain significance
hadA 732314 p.Asn129Asp missense_variant 0.81 isoniazid
hadA 732319 p.Glu130Asp missense_variant 0.77 isoniazid
hadA 732320 c.391_393delGAAinsAG frameshift_variant&missense_variant 0.81 isoniazid Uncertain significance
hadA 732329 p.Leu134Val missense_variant 0.81 isoniazid Uncertain significance
hadA 732346 c.417T>C synonymous_variant 0.78 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.73 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.75 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.79 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.91 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.96 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.93 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.97 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.94 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.96 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.83 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>C synonymous_variant 0.54 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.95 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.95 rifampicin Uncertain significance
rpoB 760139 c.333A>C synonymous_variant 0.93 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.93 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.93 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>T synonymous_variant 0.76 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.64 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.64 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.69 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.71 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.75 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.84 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.85 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760454 c.648C>G synonymous_variant 0.96 rifampicin
rpoB 760463 c.657C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.87 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.85 rifampicin
rpoB 760508 c.702G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.83 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760535 c.729C>G synonymous_variant 0.77 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.83 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.83 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.86 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.91 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.84 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760736 c.930C>G synonymous_variant 0.67 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.67 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760961 c.1155C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.68 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.59 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.62 rifampicin
rpoB 761003 c.1197C>G synonymous_variant 0.53 rifampicin
rpoB 761006 c.1200C>T synonymous_variant 0.53 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761066 c.1260G>C synonymous_variant 0.9 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.91 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.9 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.96 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.76 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.64 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761252 c.1446C>G synonymous_variant 0.86 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.77 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.75 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>C synonymous_variant 0.74 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.58 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.67 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.75 rifampicin
rpoB 761369 p.Glu521Asp missense_variant 0.86 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.75 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.55 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.46 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.68 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.73 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.93 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.96 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.98 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.95 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.94 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.88 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.71 rifampicin
rpoB 761741 c.1935G>A synonymous_variant 0.63 rifampicin
rpoB 761747 c.1941G>A synonymous_variant 0.69 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.75 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.85 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.81 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.84 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.87 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.75 rifampicin
rpoB 761816 c.2010C>G synonymous_variant 0.75 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.75 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.76 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.73 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.73 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.81 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.82 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.91 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.94 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.94 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.94 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.94 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.97 rifampicin
rpoB 761930 c.2124G>A synonymous_variant 0.97 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.9 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.9 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.67 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.83 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.84 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>T synonymous_variant 0.86 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.92 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>A synonymous_variant 0.78 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.76 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.67 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.69 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.71 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762725 c.2919C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762730 p.Gln975Arg missense_variant 0.81 rifampicin
rpoC 762734 c.-636G>A upstream_gene_variant 0.88 rifampicin
rpoB 762740 c.2934G>A synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762749 c.2943C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762753 c.2947T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762759 p.Cys985Ala missense_variant 0.88 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.92 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>T upstream_gene_variant 0.94 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762947 c.3141C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.94 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.96 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763115 c.-255T>A upstream_gene_variant 0.92 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.97 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.94 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.93 rifampicin
rpoC 763172 c.-198G>T upstream_gene_variant 0.92 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.92 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.89 rifampicin
rpoC 763217 c.-153G>C upstream_gene_variant 0.88 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.85 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.85 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.89 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.89 rifampicin
rpoC 763373 c.4_6delCTCinsTA frameshift_variant&missense_variant 0.88 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.9 rifampicin
rpoC 763411 c.42T>C synonymous_variant 0.89 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.89 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.83 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.83 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>A synonymous_variant 0.92 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.88 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.91 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.88 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.86 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.87 rifampicin
rpoC 763735 c.366G>A synonymous_variant 0.87 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.89 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.89 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763781 p.Ser138Ala missense_variant 0.82 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.8 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.83 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.79 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.76 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.79 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.74 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.74 rifampicin
rpoC 763852 c.483C>T synonymous_variant 0.73 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.71 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.74 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.65 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.65 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.65 rifampicin
rpoC 763960 c.591T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763963 c.594C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.8 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.81 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.8 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.79 rifampicin
rpoC 764023 c.654G>T synonymous_variant 0.65 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.62 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.62 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.61 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.58 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.7 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.78 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.77 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.77 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764107 c.738C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.83 rifampicin Uncertain significance
rpoC 764153 p.Gln262Lys missense_variant 0.85 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.83 rifampicin
rpoC 764170 c.801C>T synonymous_variant 0.81 rifampicin
rpoC 764182 c.813C>T synonymous_variant 0.78 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>T synonymous_variant 0.82 rifampicin
rpoC 764341 c.972G>T synonymous_variant 0.89 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>T synonymous_variant 0.88 rifampicin
rpoC 764362 c.993C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764401 c.1032C>T synonymous_variant 0.81 rifampicin
rpoC 764405 c.1036_1038delAGGinsCT frameshift_variant&missense_variant 0.74 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.77 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.84 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.83 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.83 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.9 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.9 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.9 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.95 rifampicin
rpoC 764585 c.1216_1218delCTCinsTG frameshift_variant&missense_variant 0.95 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.94 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.94 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764844 p.Ala492Gly missense_variant 0.91 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764923 c.1554A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.9 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.89 rifampicin
rpoC 765122 c.1753C>T synonymous_variant 0.89 rifampicin
rpoC 765126 p.Tyr586Phe missense_variant 0.87 rifampicin
rpoC 765246 p.Val626Ala missense_variant 0.44 rifampicin
rpoC 765256 c.1887G>T synonymous_variant 0.47 rifampicin
rpoC 765259 c.1890G>C synonymous_variant 0.47 rifampicin
rpoC 765265 p.Lys632Asn missense_variant 0.5 rifampicin
rpoC 765269 p.Lys634Arg missense_variant 0.5 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.62 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.62 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.55 rifampicin Uncertain significance
rpoC 765397 c.2028G>T synonymous_variant 0.65 rifampicin
rpoC 765400 c.2031G>C synonymous_variant 0.65 rifampicin
rpoC 765405 p.Leu679Gln missense_variant 0.65 rifampicin
rpoC 765408 p.Gly680Ala missense_variant 0.62 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.78 rifampicin
rpoC 765439 c.2070G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765458 p.Ile697Val missense_variant 0.67 rifampicin Uncertain significance
rpoC 765466 c.2097C>T synonymous_variant 0.71 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.75 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765505 c.2136C>G synonymous_variant 0.78 rifampicin
rpoC 765508 c.2139C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>A synonymous_variant 0.58 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.59 rifampicin
rpoC 765553 c.2184C>A synonymous_variant 0.59 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.53 rifampicin
rpoC 765565 c.2196G>C synonymous_variant 0.53 rifampicin
rpoC 765800 c.2431_2433delTTCinsCG frameshift_variant&missense_variant 0.8 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.86 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.94 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.93 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.91 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.74 rifampicin
rpoC 765937 c.2568T>G synonymous_variant 0.65 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.8 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766351 c.2982C>G synonymous_variant 0.8 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.83 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.81 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.81 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.81 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.76 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.58 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.58 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.7 rifampicin
rpoC 766483 c.3114G>T synonymous_variant 0.76 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.76 rifampicin
rpoC 766494 p.Gly1042Asp missense_variant 0.65 rifampicin Uncertain significance
rpoC 766513 c.3144C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766517 p.Thr1050Ser missense_variant 0.67 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 1.0 rifampicin Not assoc w R
rpoC 766651 c.3282T>C synonymous_variant 0.94 rifampicin
rpoC 766652 p.Ser1095Thr missense_variant 0.94 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.95 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.95 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.96 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.96 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.92 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.95 rifampicin
rpoC 766735 c.3366G>T synonymous_variant 0.9 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.9 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.91 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.9 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.79 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.76 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.79 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.86 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>G synonymous_variant 0.76 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.69 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766942 c.3573C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>C synonymous_variant 0.56 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766975 c.3606C>G synonymous_variant 0.83 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.85 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>C synonymous_variant 0.93 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.89 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.76 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.67 rifampicin
rpoC 767203 c.3834C>A synonymous_variant 0.59 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.69 rifampicin
rpoC 767269 c.3900C>G synonymous_variant 0.73 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.85 rifampicin
rpoC 767281 c.3912C>A synonymous_variant 0.85 rifampicin
rpoC 767284 c.3915C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 767288 c.3919C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 767296 c.3927C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
mmpL5 775817 c.2664T>C synonymous_variant 0.75 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775826 c.2655G>T synonymous_variant 0.9 clofazimine
bedaquiline
mmpL5 775829 c.2652C>G synonymous_variant 0.82 clofazimine
bedaquiline
mmpL5 775832 c.2647_2649delGCCinsTG frameshift_variant&missense_variant 0.82 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775835 c.2646C>G synonymous_variant 0.75 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.62 clofazimine
bedaquiline
mmpL5 775907 c.2572_2574delCTCinsAG frameshift_variant&missense_variant 0.76 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775913 c.2566_2568delGCCinsTT frameshift_variant&missense_variant 0.47 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775916 c.2565T>C synonymous_variant 0.8 clofazimine
bedaquiline
mmpL5 775955 c.2524_2526delATCinsGG frameshift_variant&missense_variant 0.53 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775972 p.Ala837Pro missense_variant 0.43 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.57 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.53 clofazimine
bedaquiline
mmpL5 776021 c.2458_2460delGTGinsAC frameshift_variant&missense_variant 0.6 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776024 c.2457G>C synonymous_variant 0.64 clofazimine
bedaquiline
mmpL5 776030 c.2451G>T synonymous_variant 0.68 clofazimine
bedaquiline
mmpL5 776039 c.2442C>G synonymous_variant 0.77 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.83 clofazimine
bedaquiline
mmpL5 776078 c.2403C>T synonymous_variant 0.83 clofazimine
bedaquiline
mmpL5 776087 c.2394C>T synonymous_variant 0.75 clofazimine
bedaquiline
mmpL5 776093 c.2386_2388delCGCinsAA frameshift_variant&missense_variant 0.75 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776107 c.2374C>T synonymous_variant 0.75 clofazimine
bedaquiline
mmpL5 776715 p.Lys589Pro missense_variant 0.75 clofazimine
bedaquiline
mmpL5 777094 c.1387T>C synonymous_variant 0.94 clofazimine
bedaquiline
mmpL5 777095 c.1386T>C synonymous_variant 0.94 clofazimine
bedaquiline
mmpL5 777101 c.1380C>G synonymous_variant 0.94 clofazimine
bedaquiline
mmpL5 777107 c.1374T>C synonymous_variant 0.89 clofazimine
bedaquiline
mmpL5 777110 c.1371T>G synonymous_variant 0.89 clofazimine
bedaquiline
mmpL5 777115 p.Met456Leu missense_variant 0.89 clofazimine
bedaquiline
mmpL5 777139 p.Leu448Met missense_variant 0.75 clofazimine
bedaquiline
mmpL5 777142 p.Val447Leu missense_variant 0.71 clofazimine
bedaquiline
rpsL 781595 c.36T>C synonymous_variant 0.68 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.68 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.7 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.82 streptomycin
rpsL 781622 c.63C>T synonymous_variant 0.86 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.89 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.9 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.94 streptomycin
rpsL 781655 c.96T>A synonymous_variant 0.92 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.92 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.94 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.89 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.81 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.83 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.8 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.85 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.81 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.8 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.82 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.77 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.75 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.81 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.88 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.88 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.88 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.88 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.91 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.93 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.95 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.94 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.94 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.94 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.94 streptomycin
rpsL 781895 c.336G>A synonymous_variant 0.93 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.96 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.96 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.96 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.97 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.97 streptomycin
rplC 800537 c.-272C>G upstream_gene_variant 0.78 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.76 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.75 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.7 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.74 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.89 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.9 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.9 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.92 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.92 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.91 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.91 linezolid
rplC 800744 c.-65G>T upstream_gene_variant 0.91 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.89 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.91 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.88 linezolid
rplC 800994 c.186C>G synonymous_variant 0.64 linezolid
rplC 801004 p.Leu66Val missense_variant 0.6 linezolid
rplC 801009 c.201A>G synonymous_variant 0.6 linezolid Not assoc w R - Interim
rplC 801012 c.204T>C synonymous_variant 0.6 linezolid
rplC 801018 c.210C>T synonymous_variant 0.56 linezolid
rplC 801019 c.211_213delACCinsTG frameshift_variant&missense_variant 0.56 linezolid
rplC 801127 p.Ala107Ser missense_variant 0.74 linezolid
rplC 801132 c.324T>C synonymous_variant 0.76 linezolid
rplC 801137 p.Ser110Thr missense_variant 0.79 linezolid
rplC 801141 c.333C>T synonymous_variant 0.8 linezolid
rplC 801147 c.339T>C synonymous_variant 0.8 linezolid
rplC 801156 c.348T>G synonymous_variant 0.83 linezolid
rplC 801162 c.354C>G synonymous_variant 0.87 linezolid
rplC 801168 c.360C>T synonymous_variant 0.89 linezolid
rplC 801171 c.363A>G synonymous_variant 0.88 linezolid
rplC 801174 c.366T>C synonymous_variant 0.9 linezolid
rplC 801195 c.387G>T synonymous_variant 0.92 linezolid
rplC 801205 c.397_399delCGCinsAG frameshift_variant&missense_variant 0.91 linezolid
rplC 801210 c.402T>C synonymous_variant 0.91 linezolid
rplC 801222 c.414T>C synonymous_variant 0.93 linezolid
rplC 801249 c.441T>C synonymous_variant 0.86 linezolid
rplC 801255 c.447C>T synonymous_variant 0.81 linezolid
rplC 801385 c.577C>T synonymous_variant 0.47 linezolid
rplC 801399 c.591G>C synonymous_variant 0.47 linezolid
rplC 801400 c.592_594delGTTinsAC frameshift_variant&missense_variant 0.47 linezolid
rplC 801405 c.597T>C synonymous_variant 0.5 linezolid
rplC 801413 p.Thr202Asn missense_variant 0.5 linezolid
rplC 801417 c.609T>C synonymous_variant 0.5 linezolid
rplC 801426 c.618C>G synonymous_variant 0.44 linezolid
fbiC 1303500 c.570C>T synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1303536 c.606G>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>T synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>A synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303789 p.Ile287Val missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303827 p.Glu299Asp missense_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304112 c.1182G>A synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304118 c.1188C>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304133 c.1203G>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304136 c.1206C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304547 c.1617C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304550 c.1620C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304652 c.1722C>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304706 c.1776C>T synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.64 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304949 c.2019C>T synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304991 c.2061G>A synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1305007 p.Ile693Val missense_variant 0.6 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1305012 c.2082G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1305024 c.2094C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1305348 c.2418C>T synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1305351 c.2421G>T synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1305357 c.2427C>G synonymous_variant 0.83 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305361 c.2431C>T synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1305390 c.2460C>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
sigE 1364839 c.427T>C synonymous_variant 0.64 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.79 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.88 pyrazinamide
sigE 1364865 c.453G>T synonymous_variant 0.88 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.88 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.93 pyrazinamide Uncertain significance
sigE 1364910 c.498G>T synonymous_variant 0.94 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.92 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.88 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.88 pyrazinamide
sigE 1364931 c.519C>T synonymous_variant 0.88 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.69 pyrazinamide Uncertain significance
atpE 1460816 c.-229T>C upstream_gene_variant 0.82 bedaquiline
atpE 1460822 c.-223C>G upstream_gene_variant 0.79 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.69 bedaquiline
atpE 1460837 c.-208C>G upstream_gene_variant 0.64 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.57 bedaquiline
atpE 1461188 c.144G>T synonymous_variant 0.65 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.8 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.87 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.83 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.78 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.78 bedaquiline
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>C non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473670 n.13A>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473728 n.71A>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474631 n.974G>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1474709 n.1053_1059delTGGTGTA non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475376 n.1719A>C non_coding_transcript_exon_variant 0.9 capreomycin
linezolid Uncertain significance
rrl 1475377 n.1720G>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475380 n.1723C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475762 n.2105delGinsTTT non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475764 n.2107A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid Uncertain significance
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
inhA 1674114 c.-88T>A upstream_gene_variant 0.7 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1674119 p.Glu227Gly missense_variant 0.67 ethionamide
isoniazid
inhA 1674123 c.-79T>C upstream_gene_variant 0.7 ethionamide
isoniazid
inhA 1674132 c.-70T>C upstream_gene_variant 0.74 ethionamide
isoniazid
fabG1 1674136 p.Ser233Ala missense_variant 0.78 ethionamide
isoniazid
inhA 1674141 c.-61T>C upstream_gene_variant 0.78 ethionamide
isoniazid
inhA 1674147 c.-55C>G upstream_gene_variant 0.78 ethionamide
isoniazid
inhA 1674279 c.78A>C synonymous_variant 0.82 ethionamide
isoniazid
inhA 1674280 p.Arg27Lys missense_variant 0.82 ethionamide
isoniazid
inhA 1674285 c.84A>G synonymous_variant 0.82 ethionamide
isoniazid
inhA 1674288 c.87C>G synonymous_variant 0.82 ethionamide
isoniazid
inhA 1674295 p.Gln32Ala missense_variant 0.82 ethionamide
isoniazid
inhA 1674313 c.112_114delCTCinsTG frameshift_variant&missense_variant 0.81 ethionamide
isoniazid
inhA 1674334 p.Arg45Lys missense_variant 0.5 ethionamide
isoniazid
inhA 1674507 c.306G>A synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.95 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674537 c.336C>G synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.94 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674552 c.351C>G synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674570 c.369G>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.77 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.82 ethionamide
isoniazid
inhA 1674699 c.498C>T synonymous_variant 0.84 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.85 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 0.8 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.84 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.84 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.84 ethionamide
isoniazid
inhA 1674783 c.582C>T synonymous_variant 0.79 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674786 c.585G>C synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.82 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.83 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674837 c.636C>T synonymous_variant 0.81 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674846 p.Ile215Met missense_variant 0.86 ethionamide
isoniazid
inhA 1674847 p.Gln216Lys missense_variant 0.84 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.87 ethionamide
isoniazid
inhA 1674876 c.675C>G synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.83 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674933 c.732G>T synonymous_variant 0.71 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.73 ethionamide
isoniazid
inhA 1674945 c.744C>T synonymous_variant 0.69 ethionamide
isoniazid
rpsA 1833517 c.-24delC upstream_gene_variant 0.75 pyrazinamide
rpsA 1833537 c.-5_-1delACAATinsCCAC upstream_gene_variant 0.82 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.85 pyrazinamide
rpsA 1833554 p.Thr5Ser missense_variant 0.86 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.73 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.69 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.69 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.77 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.77 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.8 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.9 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.9 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.92 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.92 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.88 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.87 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.86 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.89 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.93 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.79 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.73 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.73 pyrazinamide
rpsA 1833739 c.198C>T synonymous_variant 0.73 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.75 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.75 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.83 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.79 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.81 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.81 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.87 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.86 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.84 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.79 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.79 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.9 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.88 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.87 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.91 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.93 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.91 pyrazinamide
rpsA 1833898 c.357C>T synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
rpsA 1833901 c.360G>A synonymous_variant 0.92 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.93 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.93 pyrazinamide
rpsA 1833958 c.417C>T synonymous_variant 0.91 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.91 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.86 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.86 pyrazinamide
rpsA 1833995 c.454C>T synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
rpsA 1834000 c.459G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.78 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.78 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.8 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.84 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.85 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.94 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.89 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.88 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
rpsA 1834282 c.741C>T synonymous_variant 0.98 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.97 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.97 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.95 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.97 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.96 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.91 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.92 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.9 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.9 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.91 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.94 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.88 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.93 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.88 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.93 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.95 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 1.0 pyrazinamide
kasA 2517941 c.-174C>G upstream_gene_variant 0.88 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.85 isoniazid
kasA 2517965 c.-150C>G upstream_gene_variant 0.83 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.78 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.7 isoniazid
kasA 2517993 c.-122G>A upstream_gene_variant 0.65 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.53 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.5 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.65 isoniazid
kasA 2518153 c.39C>T synonymous_variant 0.64 isoniazid
kasA 2518162 c.48G>C synonymous_variant 0.68 isoniazid
kasA 2518168 c.54C>T synonymous_variant 0.72 isoniazid
kasA 2518174 c.60A>C synonymous_variant 0.74 isoniazid
kasA 2518186 c.72G>C synonymous_variant 0.84 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.82 isoniazid
kasA 2518219 c.105T>C synonymous_variant 0.71 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.73 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.73 isoniazid
kasA 2518231 c.117C>A synonymous_variant 0.76 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.55 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.53 isoniazid
kasA 2518819 c.705C>T synonymous_variant 0.85 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.79 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.79 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.79 isoniazid
kasA 2518849 c.735G>C synonymous_variant 0.78 isoniazid
kasA 2518853 p.Leu247Val missense_variant 0.74 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.81 isoniazid
kasA 2519047 c.933C>T synonymous_variant 0.64 isoniazid
kasA 2519049 p.Gly312Ala missense_variant 0.64 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.7 isoniazid
kasA 2519059 c.945G>T synonymous_variant 0.64 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.64 isoniazid
Rv2477c 2782426 c.1617G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782429 c.1614A>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782444 c.1599G>A synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782451 p.Ala531Gly missense_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782454 p.Gly530Ala missense_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.96 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.96 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782495 c.1548C>T synonymous_variant 0.96 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.96 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782522 c.1521G>C synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.81 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782999 c.1044C>A synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.91 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783014 p.Ser343Thr missense_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.77 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783140 c.903C>G synonymous_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783152 c.891G>A synonymous_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783155 c.888C>A synonymous_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.89 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783185 c.858G>C synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783197 c.846C>G synonymous_variant 0.91 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783200 c.843G>A synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783347 c.696C>A synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCA frameshift_variant&missense_variant 0.67 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.67 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.69 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>T synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>T synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783986 c.57G>C synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.87 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784017 p.Lys9Arg missense_variant 0.95 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784024 p.Thr7Ser missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784025 c.18C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784034 c.9G>A synonymous_variant 0.95 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784037 c.6T>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784047 c.-5G>A upstream_gene_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064998 c.1194A>C synonymous_variant 0.77 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>T synonymous_variant 0.77 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065016 c.1176C>T synonymous_variant 0.75 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065025 c.1167G>C synonymous_variant 0.77 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065031 c.1161G>C synonymous_variant 0.77 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065046 c.1146G>C synonymous_variant 0.82 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065574 c.618C>G synonymous_variant 0.58 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065595 p.Leu199Phe missense_variant 0.58 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065607 c.585C>T synonymous_variant 0.64 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065612 p.Thr194Ala missense_variant 0.64 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065613 c.579C>T synonymous_variant 0.64 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067337 p.His203Gln missense_variant 0.56 para-aminosalicylic_acid
thyX 3067343 c.603C>T synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.71 para-aminosalicylic_acid
thyX 3067364 c.582C>T synonymous_variant 0.75 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.77 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.77 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.85 para-aminosalicylic_acid
thyX 3067655 c.291G>T synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067661 c.283_285delCGCinsAG frameshift_variant&missense_variant 0.8 para-aminosalicylic_acid
thyX 3067669 c.277C>T synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067676 c.270C>T synonymous_variant 0.84 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.83 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.71 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.72 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3073920 c.550_552delCTCinsTG frameshift_variant&synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.79 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.84 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.84 para-aminosalicylic_acid
thyA 3073971 c.501C>T synonymous_variant 0.74 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.75 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.73 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.72 para-aminosalicylic_acid
thyA 3073995 c.477G>C synonymous_variant 0.71 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.59 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.69 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.73 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.69 para-aminosalicylic_acid
thyA 3074040 c.432G>C synonymous_variant 0.69 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.82 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.9 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.82 para-aminosalicylic_acid
ald 3087699 p.Leu294Val missense_variant 0.71 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.78 cycloserine
ald 3087713 c.894G>C synonymous_variant 0.82 cycloserine
ald 3087725 c.906C>G synonymous_variant 0.78 cycloserine
ald 3087727 p.Ala303Gly missense_variant 0.78 cycloserine
ald 3087729 p.Ser304Ala missense_variant 0.78 cycloserine
ald 3087738 p.Lys307Arg missense_variant 0.78 cycloserine
lpqB 3624659 c.252C>G synonymous_variant 0.72 bedaquiline
rifampicin
lpqB 3624665 c.246C>T synonymous_variant 0.76 bedaquiline
rifampicin
lpqB 3624671 c.240C>A synonymous_variant 0.76 bedaquiline
rifampicin
lpqB 3624675 p.Asn79Ser missense_variant 0.76 bedaquiline
rifampicin
lpqB 3624677 c.234C>G synonymous_variant 0.76 bedaquiline
rifampicin
lpqB 3624681 p.Ala77Gly missense_variant 0.78 bedaquiline
rifampicin
lpqB 3624701 c.210T>G synonymous_variant 0.74 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.61 bedaquiline
rifampicin
lpqB 3624725 c.186G>C synonymous_variant 0.54 bedaquiline
rifampicin
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.6 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.79 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.8 bedaquiline
rifampicin
lpqB 3625678 c.-768C>G upstream_gene_variant 0.89 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.93 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.93 bedaquiline
rifampicin
lpqB 3625723 c.-813C>G upstream_gene_variant 0.94 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.94 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.89 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.87 bedaquiline
rifampicin
mtrB 3625766 p.Ser283His missense_variant 0.85 bedaquiline
rifampicin
mtrB 3625774 c.840G>A synonymous_variant 0.87 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.72 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.66 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625845 p.Ser257Thr missense_variant 0.64 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625864 c.750T>C synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625867 c.747A>G synonymous_variant 0.65 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625876 c.738G>C synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626749 c.601C>T synonymous_variant 0.67 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626773 c.-160C>T upstream_gene_variant 0.84 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.84 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.83 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.84 bedaquiline
rifampicin
mtrA 3626792 c.558G>T synonymous_variant 0.89 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3626843 c.-230G>A upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.68 bedaquiline
rifampicin Uncertain significance
mtrB 3626990 c.-377G>T upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrB 3626993 c.-380G>T upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrB 3626996 c.-383G>C upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3626999 c.-386G>T upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3627005 c.-392G>T upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3627011 c.-398T>C upstream_gene_variant 0.81 bedaquiline
rifampicin
mtrB 3627014 c.-401G>C upstream_gene_variant 0.78 bedaquiline
rifampicin
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 0.88 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 0.81 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.83 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627077 c.-464G>C upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3627086 c.-473C>G upstream_gene_variant 0.71 bedaquiline
rifampicin
fbiA 3640320 c.-223G>A upstream_gene_variant 0.7 clofazimine
pretomanid
delamanid
rpoA 3877587 c.921A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.78 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.73 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.71 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.8 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.83 rifampicin
rpoA 3877734 c.774G>T synonymous_variant 0.83 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.86 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.93 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3877794 c.714G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.9 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.78 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.75 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.57 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.75 rifampicin
rpoA 3877929 c.579C>T synonymous_variant 0.78 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.81 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.84 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.79 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.83 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.77 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.77 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.77 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.86 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.81 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.78 rifampicin
rpoA 3878175 c.333G>C synonymous_variant 0.69 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.93 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.98 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 1.0 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.98 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.98 rifampicin
rpoA 3878406 c.102G>T synonymous_variant 0.97 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.94 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.81 rifampicin
rpoA 3878433 c.75G>T synonymous_variant 0.71 rifampicin
rpoA 3878935 c.-428C>T upstream_gene_variant 0.76 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.76 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.8 rifampicin Uncertain significance
rpoA 3878959 c.-452G>T upstream_gene_variant 0.8 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.77 rifampicin
rpoA 3878965 c.-458C>G upstream_gene_variant 0.83 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.78 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.82 rifampicin
rpoA 3879058 c.-551C>T upstream_gene_variant 0.83 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.81 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.86 rifampicin
rpoA 3879088 c.-582_-581delCAinsGC upstream_gene_variant 0.9 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.91 rifampicin
rpoA 3879115 c.-608G>T upstream_gene_variant 0.95 rifampicin
rpoA 3879121 c.-615_-614delTTinsAG upstream_gene_variant 0.92 rifampicin
ddn 3986621 c.-223G>C upstream_gene_variant 0.7 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.76 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.8 delamanid
pretomanid
ddn 3986654 c.-190C>G upstream_gene_variant 0.72 delamanid
pretomanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.78 delamanid
pretomanid
ddn 3986663 c.-181G>A upstream_gene_variant 0.82 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.82 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.82 delamanid
pretomanid
clpC1 4038293 c.2412G>C synonymous_variant 0.86 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsCC frameshift_variant&missense_variant 0.88 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.9 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.91 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.91 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.9 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.85 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.84 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.9 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.97 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4038563 c.2142C>T synonymous_variant 0.95 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.95 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.84 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.77 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.85 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.9 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.94 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.94 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.97 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4038839 c.1866G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.96 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.91 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.9 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038932 c.1773G>A synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038941 c.1764G>C synonymous_variant 0.94 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.93 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.88 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.89 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.91 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.9 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.92 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.9 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.9 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.87 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.85 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.86 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.92 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.94 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.96 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.93 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039205 c.1500C>T synonymous_variant 0.95 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039259 c.1446G>A synonymous_variant 0.92 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4039271 c.1434G>A synonymous_variant 0.89 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>C synonymous_variant 0.81 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.78 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.59 pyrazinamide
clpC1 4039355 c.1350G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.86 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.89 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.98 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.95 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039442 c.1263A>T synonymous_variant 0.93 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>T synonymous_variant 0.81 pyrazinamide
clpC1 4039457 c.1248C>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.84 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.86 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.86 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039526 c.1179G>A synonymous_variant 0.93 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.92 pyrazinamide Uncertain significance
clpC1 4039574 c.1129_1131delGCGinsCC frameshift_variant&synonymous_variant 0.93 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039613 c.1092C>T synonymous_variant 0.91 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.95 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.75 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.81 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.95 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.98 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.95 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.94 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.94 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.93 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.92 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.91 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.92 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.95 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4040108 c.597G>C synonymous_variant 0.92 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.85 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.82 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.82 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.67 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.67 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.7 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>G synonymous_variant 0.77 pyrazinamide
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.77 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4040300 c.405C>T synonymous_variant 0.88 pyrazinamide
clpC1 4040306 c.399G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040314 c.391C>T synonymous_variant 0.86 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.86 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.83 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040342 c.363C>T synonymous_variant 0.8 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.79 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.83 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.87 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.89 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040618 c.87C>A synonymous_variant 0.73 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.89 pyrazinamide
clpC1 4040657 c.48T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040669 c.36C>T synonymous_variant 0.96 pyrazinamide
clpC1 4040674 c.31A>C synonymous_variant 1.0 pyrazinamide
clpC1 4040675 c.30C>T synonymous_variant 1.0 pyrazinamide
clpC1 4040678 c.27C>G synonymous_variant 1.0 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
panD 4044162 c.120A>G synonymous_variant 0.67 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.74 pyrazinamide
panD 4044171 c.111C>T synonymous_variant 0.78 pyrazinamide
panD 4044177 c.105C>T synonymous_variant 0.78 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.68 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.74 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.77 pyrazinamide
panD 4044225 c.57C>T synonymous_variant 0.76 pyrazinamide
glpK 4138532 c.1224G>C synonymous_variant 0.76 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138562 c.1194G>C synonymous_variant 0.95 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.98 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.97 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139375 c.381T>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139387 c.369G>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139408 c.348T>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139417 c.339A>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139420 c.336T>C synonymous_variant 0.77 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139435 c.321C>G synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139648 c.108T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139653 p.His35Asp missense_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139657 c.99T>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139672 c.82_84delCGCinsAG frameshift_variant&missense_variant 0.67 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4239524 c.-339C>T upstream_gene_variant 0.78 ethambutol
embC 4239526 c.-337_-336delGGinsAC upstream_gene_variant 0.78 ethambutol
embC 4239530 c.-333C>G upstream_gene_variant 0.78 ethambutol
embC 4239533 c.-330T>C upstream_gene_variant 0.74 ethambutol
embC 4239540 c.-323T>C upstream_gene_variant 0.7 ethambutol
embC 4239545 c.-318G>A upstream_gene_variant 0.7 ethambutol Uncertain significance
embC 4239546 c.-317C>T upstream_gene_variant 0.7 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.71 ethambutol Not assoc w R - Interim
embC 4240736 p.Ser292Ala missense_variant 0.81 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.79 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.7 ethambutol Not assoc w R - Interim
embC 4240779 p.His306Arg missense_variant 0.7 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.72 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.78 ethambutol
embC 4240795 c.933C>G synonymous_variant 0.84 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.84 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.86 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.83 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.83 ethambutol
embC 4240858 c.996G>C synonymous_variant 0.9 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.8 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.77 ethambutol
embC 4241407 c.1545A>G synonymous_variant 0.84 ethambutol
embC 4241433 p.Met524Thr missense_variant 0.84 ethambutol
embC 4241435 p.Ala525Thr missense_variant 0.81 ethambutol Uncertain significance
embC 4241443 c.1581C>T synonymous_variant 0.81 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.84 ethambutol
embC 4241464 c.1602C>G synonymous_variant 0.85 ethambutol
embC 4241470 c.1608C>G synonymous_variant 0.79 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.72 ethambutol
embC 4242872 p.Asp1004Thr missense_variant 0.68 ethambutol
embC 4242878 p.Thr1006Val missense_variant 0.62 ethambutol
embA 4242901 c.-332G>C upstream_gene_variant 0.65 ethambutol
embA 4242913 c.-320C>G upstream_gene_variant 0.52 ethambutol
embA 4244675 c.1443A>G synonymous_variant 0.57 ethambutol
embA 4244681 c.1449A>C synonymous_variant 0.7 ethambutol
embA 4244694 p.Lys488Val missense_variant 0.72 ethambutol
embA 4244699 c.1467C>G synonymous_variant 0.72 ethambutol
embA 4244708 c.1476C>G synonymous_variant 0.88 ethambutol
embA 4244714 c.1482C>G synonymous_variant 0.88 ethambutol
embA 4244720 c.1488C>T synonymous_variant 0.88 ethambutol
embA 4244921 c.1689C>G synonymous_variant 0.79 ethambutol
embA 4244933 c.1701A>G synonymous_variant 0.81 ethambutol
embA 4244936 c.1704C>G synonymous_variant 0.81 ethambutol
embA 4244960 c.1728A>C synonymous_variant 0.8 ethambutol
embA 4244968 p.Gly579Ala missense_variant 0.75 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.47 ethambutol
embA 4245071 c.1839G>A synonymous_variant 0.67 ethambutol
embA 4245072 c.1840C>T synonymous_variant 0.67 ethambutol Not assoc w R - Interim
embA 4245077 c.1845G>C synonymous_variant 0.64 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embA 4245086 c.1854C>T synonymous_variant 0.64 ethambutol
embA 4245092 c.1860C>T synonymous_variant 0.71 ethambutol Not assoc w R - Interim
embA 4245101 c.1869G>C synonymous_variant 0.74 ethambutol
embB 4249492 c.2979C>G synonymous_variant 0.5 ethambutol
embB 4249519 c.3006C>T synonymous_variant 0.55 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.5 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.47 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.44 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.33 ethambutol