TB-Profiler result

Run: ERR9119525
Summary

Run ID: ERR9119525

Sample name:

Date: 2024-04-15T12:03:09.773839

Number of reads: 2612403

Percentage reads mapped: 59.34

Median coverage: 75.0

Strain: lineage4.6.2.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.6 Euro-American None 0.97
lineage4.6.2 Euro-American RD726 0.99
lineage4.6.2.2 Euro-American (Cameroon) RD726 0.98
La1.2.BCG M.bovis None 0.07
lineage4 Euro-American None 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid c.351delG Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.39 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761155 p.Ser450Leu missense_variant 0.25 rifampicin Assoc w R
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.32 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247448 p.His312Arg missense_variant 0.29 ethambutol Mutation from literature
gid 4407851 c.351delG frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 22 p.Gly8Ser missense_variant 0.16 isoniazid
dnaA 558 c.558G>C synonymous_variant 0.18 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.21 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 588 c.588A>G synonymous_variant 0.23 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.25 isoniazid
dnaA 597 c.597C>G synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>C synonymous_variant 0.25 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.23 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.23 isoniazid
dnaA 630 c.630C>G synonymous_variant 0.23 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.23 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 652 c.652_654delCTAinsTG frameshift_variant&stop_gained 0.24 isoniazid Uncertain significance
dnaA 660 c.660G>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 672 c.672T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 675 c.675C>G synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 682 c.682_684delTTGinsCC frameshift_variant&missense_variant 0.26 isoniazid Uncertain significance
dnaA 693 c.693A>G synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.24 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.24 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 753 c.753C>A synonymous_variant 0.24 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.25 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.21 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.21 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 798 c.798C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.22 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.23 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.22 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.22 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.22 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.19 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.18 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.2 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1029 c.1029C>T synonymous_variant 0.18 isoniazid
dnaA 1203 c.1203T>C synonymous_variant 0.19 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.24 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.26 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.26 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>G synonymous_variant 0.27 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.23 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.21 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.2 isoniazid
gyrB 6196 c.957C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAC frameshift_variant&missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.31 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6301 c.1062G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6367 c.-935C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6412 c.-890G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6440 p.Thr401Ala missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 6448 c.-854G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6451 c.-851A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6472 c.-830G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6496 c.-806G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6502 c.-800T>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6508 c.-794A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6532 c.-770C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6541 c.1302C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6542 c.1303_1305delATCinsTG frameshift_variant&missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6550 c.1311A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6551 c.1312T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6565 c.-737G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6586 c.-716T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.29 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6838 c.-464C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6847 c.-455C>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6862 c.-440C>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6865 c.-437G>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6866 c.-436C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.27 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7057 c.-245C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7171 c.-131C>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7201 c.-101G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>A synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7502 c.201C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7655 c.354G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7778 c.477G>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7808 c.507G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8690 c.1389C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8885 c.1584C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9008 c.1707C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9212 c.1911G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13843 c.-285T>C upstream_gene_variant 0.21 isoniazid
Rv0010c 13852 c.-296_-294delTTAinsCG upstream_gene_variant 0.21 isoniazid
Rv0010c 13860 c.-302A>G upstream_gene_variant 0.2 isoniazid
Rv0010c 13864 c.-306A>C upstream_gene_variant 0.22 isoniazid
Rv0010c 13876 c.-318G>C upstream_gene_variant 0.21 isoniazid
Rv0010c 13879 c.-321T>C upstream_gene_variant 0.19 isoniazid
fgd1 490827 c.45C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490842 c.60C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490944 c.162G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490947 c.165G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490981 c.199C>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
mshA 575587 c.240C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575590 c.243T>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575617 c.270C>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575629 c.282A>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.22 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.22 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.27 ethionamide
isoniazid
mshA 575722 c.375G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575746 c.399C>T synonymous_variant 0.36 ethionamide
isoniazid
mshA 575770 c.423G>T synonymous_variant 0.38 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.37 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.36 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575845 c.498C>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.2 ethionamide
isoniazid
mshA 575938 c.591G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575953 c.606G>C synonymous_variant 0.21 ethionamide
isoniazid
ccsA 619543 c.-348C>G upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619558 c.-333G>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619618 c.-273C>G upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620198 p.Gln103Leu missense_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.23 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620682 c.792G>A synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>T synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>A synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620697 c.807C>T synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAT frameshift_variant&missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAG frameshift_variant&missense_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>A synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620809 c.919C>T synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620829 c.939G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620832 c.942C>T synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620835 c.945C>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620844 c.954C>T synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620847 c.957G>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
Rv0565c 656349 c.1122G>A synonymous_variant 0.18 ethionamide
Rv0565c 656371 p.Pro367His missense_variant 0.17 ethionamide
Rv0565c 656384 p.Val363Ile missense_variant 0.16 ethionamide
Rv0565c 656385 c.1086C>T synonymous_variant 0.16 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.21 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.24 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.24 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.24 ethionamide
Rv0565c 656430 c.1041C>G synonymous_variant 0.25 ethionamide
Rv0565c 656448 c.1023T>C synonymous_variant 0.25 ethionamide
Rv0565c 656454 c.1017G>C synonymous_variant 0.23 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.23 ethionamide
Rv0565c 656478 c.993C>G synonymous_variant 0.22 ethionamide
Rv0565c 656481 c.990A>G synonymous_variant 0.2 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.2 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.2 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.22 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.23 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.23 ethionamide Not assoc w R - Interim
Rv0565c 656534 p.Arg313Gly missense_variant 0.25 ethionamide
Rv0565c 656538 p.Ser311Ala missense_variant 0.23 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.19 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.19 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.19 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.18 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.23 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.17 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.2 isoniazid
hadA 732280 c.351C>T synonymous_variant 0.24 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.25 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.26 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.26 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.28 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.31 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.32 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.36 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.37 isoniazid
hadA 732355 c.426G>C synonymous_variant 0.39 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.33 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.37 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.34 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.33 isoniazid
nusG 734078 c.-176C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
nusG 734093 c.-161A>C upstream_gene_variant 0.2 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.2 rifampicin
nusG 734123 c.-131C>T upstream_gene_variant 0.17 rifampicin
nusG 734135 c.-119G>T upstream_gene_variant 0.18 rifampicin
nusG 734144 c.-110G>T upstream_gene_variant 0.2 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.23 rifampicin
nusG 734173 c.-81C>G upstream_gene_variant 0.22 rifampicin
nusG 734175 c.-79_-77delGGTinsCTG upstream_gene_variant 0.22 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.23 rifampicin Uncertain significance
nusG 734186 c.-68G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
nusG 734205 c.-49A>C upstream_gene_variant 0.23 rifampicin
nusG 734247 c.-7_-6delGAinsC upstream_gene_variant 0.18 rifampicin
nusG 734370 c.117A>G synonymous_variant 0.24 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.31 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.35 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.33 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.32 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.32 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.37 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.37 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.37 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.26 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.26 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.26 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.27 rifampicin
nusG 734604 c.351C>T synonymous_variant 0.32 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.33 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.3 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.3 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.3 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.3 rifampicin
nusG 734646 c.393G>C synonymous_variant 0.29 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.31 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.3 rifampicin
nusG 734664 c.411T>G synonymous_variant 0.3 rifampicin
nusG 734667 c.414C>T synonymous_variant 0.3 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.3 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734680 c.427_429delGCCinsAG frameshift_variant&missense_variant 0.29 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.3 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.28 rifampicin
nusG 734715 c.462G>C synonymous_variant 0.27 rifampicin
nusG 734718 c.465G>C synonymous_variant 0.27 rifampicin
nusG 734719 p.Ser156Ala missense_variant 0.28 rifampicin
nusG 734726 p.Arg158Lys missense_variant 0.32 rifampicin
nusG 734733 c.480T>C synonymous_variant 0.33 rifampicin
nusG 734742 c.489T>C synonymous_variant 0.38 rifampicin
nusG 734750 p.Ser166Thr missense_variant 0.3 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.29 rifampicin
nusG 734771 p.Ala173Val missense_variant 0.27 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.25 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.24 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.25 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.28 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.28 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.26 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.22 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.2 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.2 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.2 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.2 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.19 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.2 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.21 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.31 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.32 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.34 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.38 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.44 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.48 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.48 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.5 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.44 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.43 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.41 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760520 c.714C>G synonymous_variant 0.3 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.29 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.23 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.27 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.25 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.29 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.27 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.39 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.36 rifampicin
rpoB 760765 p.Glu320Ala missense_variant 0.37 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.35 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.38 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.39 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.37 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.35 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.33 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.3 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.29 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.32 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.29 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.27 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.24 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.26 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.25 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.27 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.32 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>G synonymous_variant 0.37 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.35 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.36 rifampicin
rpoB 761106 c.1301_1303delTGG disruptive_inframe_deletion 0.32 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.19 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.18 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.19 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.24 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.33 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.35 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.34 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.33 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.25 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.28 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.28 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.27 rifampicin
rpoB 761699 c.1893C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761774 p.His656Gln missense_variant 0.19 rifampicin Uncertain significance
rpoB 761791 p.Arg662His missense_variant 0.19 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.21 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.21 rifampicin
rpoB 761831 c.2025C>T synonymous_variant 0.21 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.19 rifampicin
rpoB 761846 c.2040G>A synonymous_variant 0.18 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.2 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.2 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.19 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.18 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.23 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.19 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.2 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.34 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.34 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.33 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.39 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.39 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.35 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.35 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.35 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.36 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.35 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.32 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.32 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.31 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.28 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.27 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.35 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.38 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.3 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.3 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.26 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.23 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.24 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.23 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.24 rifampicin
rpoB 762736 p.Ala977Glu missense_variant 0.23 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.27 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.32 rifampicin
rpoB 762785 p.Asp993Glu missense_variant 0.42 rifampicin Uncertain significance
rpoB 762789 p.Leu995Met missense_variant 0.41 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.44 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.44 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.44 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.5 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.4 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.42 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.42 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 762998 c.-372G>A upstream_gene_variant 0.43 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.48 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.47 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.47 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.37 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.37 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.37 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.37 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.29 rifampicin
rpoC 763262 c.-108C>G upstream_gene_variant 0.3 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.33 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.35 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.46 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.39 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763600 c.231C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.45 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.48 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.48 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.47 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.45 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.37 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.34 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.33 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.32 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.23 rifampicin
rpoC 763852 c.483C>G synonymous_variant 0.21 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.2 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.2 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.19 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.19 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.19 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763930 c.561G>A synonymous_variant 0.25 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.27 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.26 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.26 rifampicin
rpoC 764002 c.633C>T synonymous_variant 0.27 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.29 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.29 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.28 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.29 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.3 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.3 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.31 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.3 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.3 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764198 c.829C>T synonymous_variant 0.27 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.26 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.25 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.31 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.3 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.3 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.37 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.29 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.29 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.26 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.21 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.22 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.27 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.26 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.26 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.31 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.38 rifampicin
rpoC 764647 c.1278C>T synonymous_variant 0.39 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.42 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.25 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.29 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765330 p.Ser654Asn missense_variant 0.18 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765361 c.1992C>A synonymous_variant 0.26 rifampicin
rpoC 765370 c.2001G>T synonymous_variant 0.25 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.25 rifampicin
rpoC 765379 c.2010G>T synonymous_variant 0.27 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.27 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.31 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.33 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.31 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.33 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.33 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.33 rifampicin
rpoC 765469 c.2100G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.4 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.38 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.4 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.38 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.39 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.36 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.36 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.37 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.31 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.39 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.36 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.36 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.39 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.39 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.41 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.38 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.38 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.35 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.37 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.26 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.34 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.35 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.34 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.37 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.33 rifampicin
rpoC 766080 c.2712_2715delTGCA frameshift_variant 0.24 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.25 rifampicin
rpoC 766097 p.Leu910Val missense_variant 0.26 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.2 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.17 rifampicin
rpoC 766327 c.2958C>G synonymous_variant 0.18 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.2 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.21 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.21 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.21 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.25 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.26 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.31 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.34 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.33 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.28 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.24 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.25 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766513 c.3144C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.31 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.29 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.27 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.34 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.35 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.37 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.34 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.36 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.39 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.41 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.38 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.38 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.38 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.37 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.37 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.29 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.35 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.4 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.39 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.4 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.4 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.41 rifampicin
rpoC 766924 p.Glu1185Asp missense_variant 0.41 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.45 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 0.51 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.52 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>A synonymous_variant 0.51 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.49 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.39 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.33 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.33 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767278 c.3909T>C synonymous_variant 0.28 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775817 c.2664T>C synonymous_variant 0.19 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775829 c.2652C>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775832 c.2647_2649delGCCinsTG frameshift_variant&missense_variant 0.23 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775835 c.2646C>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775847 c.2634G>C synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775851 p.Ser877Thr missense_variant 0.24 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775864 p.Ala873Ser missense_variant 0.23 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsCG frameshift_variant&missense_variant 0.23 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.27 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 775921 c.2560C>T synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 778298 c.183G>A synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.15 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.24 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.24 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.22 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.23 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.32 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.34 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.32 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.36 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.44 streptomycin
rpsL 781718 c.159C>T synonymous_variant 0.44 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.45 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.47 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.48 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.47 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.47 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.48 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.48 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.47 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.46 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.45 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.45 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.36 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.36 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.37 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.32 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.34 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.4 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.44 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.26 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.31 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.33 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.36 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.34 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.36 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.36 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.35 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.29 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.19 linezolid
rplC 800856 c.48A>G synonymous_variant 0.18 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.18 linezolid
rplC 800889 c.81C>G synonymous_variant 0.21 linezolid
rplC 800892 c.84G>C synonymous_variant 0.21 linezolid
rplC 800904 c.96G>C synonymous_variant 0.19 linezolid
rplC 800907 c.99C>G synonymous_variant 0.2 linezolid
rplC 800939 p.Arg44His missense_variant 0.15 linezolid
rplC 801156 c.348T>C synonymous_variant 0.21 linezolid
rplC 801171 c.363A>G synonymous_variant 0.26 linezolid
rplC 801174 c.366T>C synonymous_variant 0.24 linezolid
rplC 801195 c.387G>C synonymous_variant 0.24 linezolid
rplC 801207 c.399C>T synonymous_variant 0.21 linezolid
rplC 801210 c.402T>C synonymous_variant 0.22 linezolid
rplC 801222 c.414T>C synonymous_variant 0.22 linezolid
rplC 801249 c.441T>C synonymous_variant 0.23 linezolid
rplC 801255 c.447C>T synonymous_variant 0.23 linezolid
rplC 801267 c.459A>T synonymous_variant 0.22 linezolid
rplC 801270 c.462T>C synonymous_variant 0.22 linezolid
rplC 801276 c.468G>C synonymous_variant 0.21 linezolid
rplC 801282 c.474G>C synonymous_variant 0.23 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 0.21 linezolid
rplC 801312 c.504G>C synonymous_variant 0.2 linezolid
rplC 801321 c.513C>T synonymous_variant 0.19 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.19 linezolid
rplC 801327 c.519C>T synonymous_variant 0.19 linezolid
rplC 801330 c.522G>C synonymous_variant 0.2 linezolid
rplC 801339 c.531T>C synonymous_variant 0.2 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.2 linezolid
rplC 801348 c.540T>G synonymous_variant 0.2 linezolid
rplC 801357 c.549T>C synonymous_variant 0.2 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.21 linezolid
fbiC 1303534 p.Ser202Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303647 c.717G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303653 c.723G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Thr missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303932 c.1002G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303935 c.1005G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304137 p.Ala403Ser missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304205 c.1275C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304943 c.2013C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304944 c.2014C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305039 c.2109G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473752 n.95G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473936 n.279A>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475758 n.2104delC non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476717 n.3060C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
inhA 1673393 c.-809G>C upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673568 c.-634C>G upstream_gene_variant 0.2 ethionamide
isoniazid
fabG1 1673569 p.Val44Ile missense_variant 0.21 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.2 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.22 ethionamide
isoniazid
inhA 1673601 c.-601G>A upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673610 c.-592C>T upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673625 c.-577C>G upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.24 ethionamide
isoniazid
fabG1 1673641 p.Val68Ile missense_variant 0.23 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673682 c.-520G>C upstream_gene_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673710 p.Leu91Ile missense_variant 0.17 ethionamide
isoniazid
inhA 1673716 c.-486G>A upstream_gene_variant 0.18 ethionamide
isoniazid Uncertain significance
inhA 1674205 p.Thr2Ala missense_variant 0.16 ethionamide
isoniazid Uncertain significance
inhA 1674216 c.15G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674235 c.34_36delGTTinsAC frameshift_variant&missense_variant 0.18 ethionamide
isoniazid
inhA 1674238 c.37_38delAGinsTC synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674243 c.42A>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674279 c.78A>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674280 p.Arg27Lys missense_variant 0.21 ethionamide
isoniazid
inhA 1674284 p.Val28Ala missense_variant 0.22 ethionamide
isoniazid
inhA 1674295 p.Gln32Ala missense_variant 0.23 ethionamide
isoniazid
inhA 1674300 c.99C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674303 c.102C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674307 c.106C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674324 c.123C>T synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674331 c.130C>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674336 c.135G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674352 p.Thr51Ala missense_variant 0.25 ethionamide Uncertain significance
isoniazid
inhA 1674471 c.270G>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674489 c.288G>T synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.33 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.33 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.33 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.33 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.3 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.35 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674756 c.555T>A synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674786 c.585G>A synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.4 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674816 c.615T>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.37 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.31 ethionamide
isoniazid
inhA 1674934 c.733C>T synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674949 c.748C>T synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674954 c.753G>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674966 c.765T>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.22 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.27 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.33 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.32 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.45 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.48 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.49 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.49 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.49 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.39 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.34 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.25 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834225 c.684C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.42 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834546 c.1005T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.35 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834684 c.1143C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.29 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.3 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.28 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.27 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.2 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.46 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.42 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.45 linezolid
tsnR 1853390 c.-216G>A upstream_gene_variant 0.45 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.44 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.37 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.36 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.32 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.29 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.29 linezolid
tsnR 1853459 c.-147G>T upstream_gene_variant 0.25 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.21 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063187 c.1542C>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
bacA 2064892 c.-164A>G upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064912 c.-184A>G upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064945 c.-217G>A upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064969 c.-241T>C upstream_gene_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064975 c.-247G>C upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064996 c.-268G>C upstream_gene_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
ndh 2102260 c.783C>T synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102266 c.777C>G synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102317 c.726A>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102328 p.Leu239Met missense_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102334 p.Gln237Glu missense_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102337 c.706T>C synonymous_variant 0.27 ethionamide Not assoc w R - Interim
delamanid
isoniazid
ndh 2102344 c.699T>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102350 c.693G>T synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102365 p.Ala226Glu missense_variant 0.2 ethionamide
delamanid
isoniazid Uncertain significance
ndh 2102373 p.Met224Leu missense_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102377 c.666A>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102407 c.636T>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102527 c.516A>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102533 c.510A>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.21 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.21 isoniazid Uncertain significance
katG 2155680 c.432G>C synonymous_variant 0.22 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.23 isoniazid
katG 2155692 c.420C>T synonymous_variant 0.23 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.24 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.27 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.25 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.26 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.22 isoniazid
katG 2155741 p.Gly124Asp missense_variant 0.18 isoniazid Uncertain significance
katG 2155767 c.345C>T synonymous_variant 0.17 isoniazid
Rv1979c 2221746 c.1416_1418dupCCG disruptive_inframe_insertion 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.41 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.41 isoniazid
kasA 2517950 c.-165C>T upstream_gene_variant 0.36 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.29 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.24 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.23 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.21 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.21 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.22 isoniazid
kasA 2518168 c.54C>T synonymous_variant 0.23 isoniazid
kasA 2518172 c.58_60delACAinsGG frameshift_variant&missense_variant 0.23 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.23 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.24 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.28 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.28 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.22 isoniazid
kasA 2518488 p.Ser125Thr missense_variant 0.2 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.23 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.24 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.28 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.31 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.32 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.3 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.3 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.29 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.3 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.3 isoniazid
kasA 2518603 c.489G>C synonymous_variant 0.31 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.3 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.31 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.3 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.31 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.3 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.3 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.3 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.3 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.28 isoniazid
kasA 2518696 c.582C>T synonymous_variant 0.28 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.29 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.29 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.29 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.29 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.33 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.39 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.34 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.39 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.38 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.38 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.37 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.37 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.34 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.34 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.33 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.35 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.34 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.3 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.3 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.28 isoniazid
kasA 2518882 c.768C>T synonymous_variant 0.27 isoniazid
kasA 2518897 c.783G>A synonymous_variant 0.22 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.22 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.2 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.2 isoniazid
folC 2746308 p.Arg431Ser missense_variant 0.22 para-aminosalicylic_acid
folC 2746320 p.Pro427Ala missense_variant 0.79 para-aminosalicylic_acid
folC 2746321 c.1278A>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2746335 p.Gly422Arg missense_variant 0.23 para-aminosalicylic_acid
folC 2746336 c.1263C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746351 c.1246_1248delGCCinsTG frameshift_variant&missense_variant 0.23 para-aminosalicylic_acid
folC 2746360 c.1239T>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2746363 c.1236G>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2746366 c.1233G>A synonymous_variant 0.21 para-aminosalicylic_acid
folC 2746375 c.1224G>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746378 c.1221G>A synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746393 c.1206C>G synonymous_variant 0.27 para-aminosalicylic_acid
folC 2746401 p.Ser400Ala missense_variant 0.23 para-aminosalicylic_acid
folC 2746402 c.1197T>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2746416 p.Glu395Gln missense_variant 0.22 para-aminosalicylic_acid
folC 2746420 c.1179A>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2746960 c.639C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2746967 p.Gly211Ala missense_variant 0.2 para-aminosalicylic_acid
folC 2746974 p.Ile209Leu missense_variant 0.19 para-aminosalicylic_acid
folC 2746979 p.Ala207Asp missense_variant 0.19 para-aminosalicylic_acid
folC 2746981 c.618T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2746984 c.615C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2746987 c.612T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2746990 p.Asp203Glu missense_variant 0.19 para-aminosalicylic_acid
folC 2746999 c.600T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747002 c.597T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747007 p.Ser198Cys missense_variant 0.19 para-aminosalicylic_acid
folC 2747023 c.576C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747032 c.567A>C synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747242 c.357G>A synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747264 p.Gly112Ser missense_variant 0.21 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.28 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.25 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747425 c.174C>T synonymous_variant 0.18 para-aminosalicylic_acid
Rv2477c 2782432 c.1609_1611delGTGinsAC frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782453 c.1590C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782603 c.1440G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782608 p.Gly479Ser missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782612 c.1431T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782636 c.1407G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782669 c.1374A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782714 c.1329A>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782720 c.1323T>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782738 c.1305C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782913 p.Ser377Ile missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.41 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.44 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783680 c.363G>A synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783838 p.Thr69Ser missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859870 c.549T>C synonymous_variant 0.19 clofazimine
bedaquiline
pepQ 2859873 c.546T>C synonymous_variant 0.2 clofazimine
bedaquiline
pepQ 2859882 c.537G>C synonymous_variant 0.27 clofazimine
bedaquiline
pepQ 2859903 c.516G>C synonymous_variant 0.25 clofazimine
bedaquiline
pepQ 2859908 p.Gln171Glu missense_variant 0.24 clofazimine
bedaquiline
pepQ 2859909 c.510G>C synonymous_variant 0.24 clofazimine
bedaquiline
pepQ 2859918 c.501A>G synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859921 c.498C>G synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859939 c.480C>G synonymous_variant 0.2 clofazimine
bedaquiline
pepQ 2859942 c.477C>G synonymous_variant 0.2 clofazimine
bedaquiline
Rv2680 2996208 p.Ala35Asp missense_variant 1.0 capreomycin Uncertain significance
Rv2752c 3064838 c.1354T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064872 c.1320T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3064877 p.Ser439Ala missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064883 p.Ser437Cys missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064905 c.1287C>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064911 c.1281C>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064914 c.1278T>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064928 c.1264T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065985 c.207C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065993 p.Val67Ile missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065997 c.195C>T synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066003 c.189C>T synonymous_variant 0.18 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066045 c.147T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066095 p.Val33Ile missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066132 c.60G>T synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066135 c.57C>T synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066741 c.-550T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-567_-565delCGGinsAC upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066783 c.-592G>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066816 c.-625G>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067277 c.669C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.26 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067313 c.633G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067319 c.627G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGG frameshift_variant&missense_variant 0.3 para-aminosalicylic_acid
thyX 3067469 c.477C>T synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067472 c.474C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067496 c.450G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067499 c.447G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067502 c.444C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.25 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.2 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067586 c.360C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.24 para-aminosalicylic_acid
thyX 3067616 c.330C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067676 c.270C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067679 p.Cys89Leu missense_variant 0.27 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067693 p.Ile85Val missense_variant 0.28 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067713 p.Val78Ala missense_variant 0.36 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.28 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.28 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067838 c.108C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.28 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067935 p.Thr4Ile missense_variant 0.17 para-aminosalicylic_acid
thyA 3073845 c.627C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.25 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.33 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3073893 c.579C>T synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.34 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.39 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074064 c.408C>T synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074121 c.351T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074124 c.348G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074142 c.330C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.25 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.23 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074184 c.288A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.21 para-aminosalicylic_acid
thyA 3074216 p.Asp86Asn missense_variant 0.19 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.2 para-aminosalicylic_acid
ald 3087751 p.Tyr311Phe missense_variant 0.18 cycloserine
ald 3087758 c.939G>C synonymous_variant 0.21 cycloserine
ald 3087770 c.951G>C synonymous_variant 0.2 cycloserine
ald 3087776 c.957G>A synonymous_variant 0.17 cycloserine
ald 3087787 p.Glu323Ala missense_variant 0.21 cycloserine
ald 3087791 c.972T>C synonymous_variant 0.21 cycloserine
ald 3087799 p.His327Arg missense_variant 0.21 cycloserine
ald 3087821 c.1002G>C synonymous_variant 0.23 cycloserine
ald 3087825 p.Asn336Asp missense_variant 0.25 cycloserine
ald 3087829 p.Pro337His missense_variant 0.22 cycloserine
ald 3087833 c.1014A>T synonymous_variant 0.22 cycloserine
ald 3087836 c.1017A>G synonymous_variant 0.21 cycloserine
ald 3087845 c.1026T>C synonymous_variant 0.19 cycloserine
Rv3083 3448567 p.His22Asp missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623404 p.Ile503Leu missense_variant 0.21 bedaquiline
rifampicin
lpqB 3623408 c.1503C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623411 c.1500T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3623417 c.1494A>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3623428 c.1483T>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3623441 p.Ser490Asn missense_variant 0.21 bedaquiline
rifampicin
lpqB 3623444 c.1467T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623465 c.1446G>C synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3623468 c.1443T>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623472 p.Tyr480Phe missense_variant 0.29 bedaquiline
rifampicin
lpqB 3623480 c.1431C>G synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3623484 p.Phe476Tyr missense_variant 0.29 bedaquiline
rifampicin
lpqB 3623492 c.1419T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623507 c.1404C>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3623512 p.Gly467Ser missense_variant 0.26 bedaquiline
rifampicin
lpqB 3623516 c.1395C>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623519 c.1392C>T synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3623528 c.1383G>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623531 c.1380T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3623552 c.1359G>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3623570 c.1341A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623576 c.1335T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3623587 p.Ala442Pro missense_variant 0.2 bedaquiline
rifampicin
lpqB 3623597 c.1314C>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3623601 p.Ser437Thr missense_variant 0.18 bedaquiline
rifampicin
lpqB 3624050 c.861C>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624063 p.Asn283Ser missense_variant 0.2 bedaquiline
rifampicin
lpqB 3624074 c.837G>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624077 c.834G>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624089 c.822C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624094 c.817A>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624133 c.778A>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.24 bedaquiline
rifampicin
lpqB 3624173 c.738A>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624179 c.732C>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624188 c.723G>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624194 c.717C>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624200 c.711A>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624209 c.702A>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624224 c.687T>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624242 c.669A>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624245 c.666A>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624254 c.657T>C synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624266 c.645T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624269 c.642G>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624276 p.Arg212His missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624695 c.216C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3625510 c.-600T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625540 c.-630G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625552 c.-642G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625572 p.Thr348Ser missense_variant 0.23 bedaquiline
rifampicin
lpqB 3625573 c.-663G>A upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.28 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625741 c.-831G>A upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.42 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.39 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625888 c.726G>A synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625909 c.-999T>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.34 bedaquiline
rifampicin
mtrB 3625930 c.684C>G synonymous_variant 0.34 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.672C>G synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3625945 c.669A>G synonymous_variant 0.3 bedaquiline
rifampicin
mtrB 3625955 p.Leu220Ala missense_variant 0.28 bedaquiline
rifampicin
mtrB 3625967 p.Ala216Ile missense_variant 0.21 bedaquiline
rifampicin
mtrB 3625972 c.642G>C synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3626316 c.298C>T synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3626325 p.Thr97Ala missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626329 c.285G>A synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3626349 p.Ser89Gly missense_variant 0.21 bedaquiline
rifampicin
mtrB 3626350 c.264C>G synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3626377 p.Asp79Glu missense_variant 0.28 bedaquiline
rifampicin
mtrB 3626383 c.231G>C synonymous_variant 0.27 bedaquiline
rifampicin
mtrB 3626386 c.228G>C synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3626390 p.Arg75Lys missense_variant 0.28 bedaquiline
rifampicin
mtrB 3626400 p.Ile72Val missense_variant 0.26 bedaquiline
rifampicin
mtrB 3626407 c.207C>G synonymous_variant 0.27 bedaquiline
rifampicin
mtrB 3626410 c.204T>C synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626425 c.189C>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626433 c.181C>T synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626708 c.642G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626711 c.-98T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626720 c.-107G>A upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626735 c.-122C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626744 c.-131G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.33 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626849 c.-236C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627005 c.-392G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.162A>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
fbiB 3642614 c.1080C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642743 c.1209T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642749 c.1215T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642758 c.1224C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
rpoA 3877515 c.993G>C synonymous_variant 0.19 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.27 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.26 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.33 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.28 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.23 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.24 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.28 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.31 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.31 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.29 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.28 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Asn missense_variant 0.26 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.25 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.19 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878064 c.444G>T synonymous_variant 0.17 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.18 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.26 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.25 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.25 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.25 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.29 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.34 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.32 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.28 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.32 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.32 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878328 c.180G>A synonymous_variant 0.29 rifampicin
rpoA 3878331 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.24 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.27 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.27 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.27 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.31 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.3 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.32 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.33 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.26 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.26 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.23 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.23 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.22 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.2 rifampicin
rpoA 3878483 c.25C>T synonymous_variant 0.19 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.2 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.18 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.2 rifampicin
rpoA 3878694 c.-187A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.18 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.23 rifampicin
rpoA 3878734 c.-229_-227delATCinsGG upstream_gene_variant 0.22 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.3 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.36 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.4 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.39 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.39 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.42 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.35 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.35 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.39 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.43 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.31 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.29 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878956 c.-449G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.28 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.32 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.29 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879022 c.-515G>T upstream_gene_variant 0.28 rifampicin
rpoA 3879028 c.-521C>T upstream_gene_variant 0.31 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.29 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.31 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.31 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.23 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.23 rifampicin
ddn 3986633 c.-211C>G upstream_gene_variant 0.41 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.4 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986651 c.-193G>A upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986657 c.-187C>G upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.23 delamanid
pretomanid
ddn 3987011 c.168C>T synonymous_variant 1.0 delamanid Not assoc w R - Interim
pretomanid
clpC1 4038212 c.2493T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038218 c.2487G>A synonymous_variant 0.27 pyrazinamide
clpC1 4038239 c.2466T>A synonymous_variant 0.32 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.37 pyrazinamide
clpC1 4038269 c.2434_2436delCCCinsGG frameshift_variant&missense_variant 0.37 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.36 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038289 p.Asn806Asp missense_variant 0.42 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.46 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.47 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038395 c.2310C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.37 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.35 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.31 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.32 pyrazinamide
clpC1 4038458 c.2247G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.33 pyrazinamide
clpC1 4038488 c.2217C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038498 p.Ser736Asn missense_variant 0.35 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.31 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.3 pyrazinamide
clpC1 4038587 c.2118C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.36 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.36 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038656 c.2047_2049delAAGinsCA frameshift_variant&missense_variant 0.35 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.36 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.47 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.46 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.47 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.4 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.31 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.29 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039328 p.Ala459Gly missense_variant 0.22 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.21 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039364 c.1341C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.28 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039616 c.1089G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.39 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039991 c.714G>T synonymous_variant 0.23 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.23 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.24 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040132 c.573C>T synonymous_variant 0.28 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAC frameshift_variant&missense_variant 0.18 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.23 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040240 c.465C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>A synonymous_variant 0.29 pyrazinamide
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.29 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040330 c.375C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.21 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
panD 4044084 c.198T>C synonymous_variant 0.24 pyrazinamide
panD 4044093 c.189A>G synonymous_variant 0.24 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.26 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.28 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.31 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.33 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.33 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.34 pyrazinamide
panD 4044174 c.108C>G synonymous_variant 0.35 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.36 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.36 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.36 pyrazinamide
panD 4044237 c.45G>C synonymous_variant 0.24 pyrazinamide
panD 4044240 c.42G>C synonymous_variant 0.24 pyrazinamide
panD 4044262 p.Lys7Arg missense_variant 0.22 pyrazinamide
panD 4044264 c.18G>C synonymous_variant 0.18 pyrazinamide
glpK 4138580 c.1176C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138829 c.927A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139207 c.549T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139249 c.507C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139255 c.501G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139297 c.459G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240657 c.795G>C synonymous_variant 0.25 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.27 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.28 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.29 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.31 ethambutol
embC 4240698 p.Ala279Gly missense_variant 0.33 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.37 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.35 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.35 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.39 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.39 ethambutol
embC 4240859 p.Leu333Val missense_variant 0.26 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.26 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.26 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.28 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.26 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.24 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.24 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.28 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.28 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.31 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.28 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.27 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.28 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.28 ethambutol
embC 4240978 c.1116G>A synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.25 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.28 ethambutol
embC 4240990 c.1128A>C synonymous_variant 0.31 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.34 ethambutol
embC 4241020 c.1158G>C synonymous_variant 0.3 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.34 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.37 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.42 ethambutol
embC 4241048 c.1186_1188delCTTinsTG frameshift_variant&missense_variant 0.43 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.43 ethambutol
embC 4241116 c.1254C>G synonymous_variant 0.45 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.48 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embC 4241158 c.1296T>C synonymous_variant 0.4 ethambutol
embC 4241161 c.1299C>T synonymous_variant 0.39 ethambutol
embC 4241162 c.1300T>C synonymous_variant 0.38 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.41 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.27 ethambutol
embC 4241656 c.1794G>A synonymous_variant 0.18 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.19 ethambutol
embC 4241671 c.1809T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241694 p.Ala611Val missense_variant 0.19 ethambutol
embC 4241707 c.1845G>A synonymous_variant 0.17 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244324 c.1092T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4244345 c.1113C>G synonymous_variant 0.2 ethambutol
embA 4244366 c.1134C>A synonymous_variant 0.19 ethambutol
embA 4244372 c.1140T>G synonymous_variant 0.19 ethambutol
embA 4244378 c.1146G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4244390 c.1158G>C synonymous_variant 0.2 ethambutol
embA 4244960 c.1728A>G synonymous_variant 0.19 ethambutol
embA 4244980 p.Val583Ala missense_variant 0.21 ethambutol
embA 4244982 c.1750T>C synonymous_variant 0.21 ethambutol
embA 4244987 c.1755T>C synonymous_variant 0.24 ethambutol
embA 4245003 p.Thr591Ala missense_variant 0.25 ethambutol Uncertain significance
embA 4245006 p.Phe592Leu missense_variant 0.24 ethambutol
embA 4245014 c.1782C>G synonymous_variant 0.24 ethambutol
embA 4245023 c.1791A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4245026 c.1794T>C synonymous_variant 0.22 ethambutol
embA 4245028 p.Ser599Asn missense_variant 0.24 ethambutol
embA 4245032 c.1800A>C synonymous_variant 0.26 ethambutol
embA 4245041 c.1809C>G synonymous_variant 0.24 ethambutol
embA 4245056 c.1824C>G synonymous_variant 0.23 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.24 ethambutol
embA 4245078 p.Trp616Val missense_variant 0.22 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4245093 p.Ile621Val missense_variant 0.24 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.24 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.25 ethambutol
embA 4245143 c.1911C>T synonymous_variant 0.24 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.23 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.2 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.2 ethambutol
embA 4245198 p.Leu656Ala missense_variant 0.21 ethambutol
embA 4245206 c.1974A>C synonymous_variant 0.2 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.2 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.2 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
embB 4247425 c.912G>A synonymous_variant 0.27 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.29 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.3 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.31 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.32 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.33 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.3 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.27 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.23 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.2 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.2 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>T synonymous_variant 0.21 ethambutol
embB 4247842 c.1329T>C synonymous_variant 0.22 ethambutol
embB 4247857 c.1344C>A synonymous_variant 0.26 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.32 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.28 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.27 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247908 c.1395C>T synonymous_variant 0.21 ethambutol
embB 4247909 c.1396T>C synonymous_variant 0.21 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247920 c.1407T>C synonymous_variant 0.22 ethambutol
embB 4247923 c.1410T>C synonymous_variant 0.21 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.23 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.24 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.23 ethambutol
embB 4247974 c.1461C>A synonymous_variant 0.25 ethambutol
embB 4247980 c.1467C>A synonymous_variant 0.27 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.29 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.18 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.21 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.25 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.2 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.21 ethambutol
embB 4248121 c.1608G>C synonymous_variant 0.2 ethambutol
embB 4248130 c.1617G>T synonymous_variant 0.2 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.2 ethambutol
embB 4248169 c.1656C>G synonymous_variant 0.24 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.25 ethambutol
embB 4248175 c.1662G>C synonymous_variant 0.25 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.32 ethambutol
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.28 ethambutol
embB 4248211 c.1698G>T synonymous_variant 0.27 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.27 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4248226 c.1713G>C synonymous_variant 0.28 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.2 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.18 ethambutol
embB 4249069 c.2556A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249072 c.2559G>A synonymous_variant 0.21 ethambutol
embB 4249075 c.2562A>G synonymous_variant 0.2 ethambutol
embB 4249083 p.Thr857Arg missense_variant 0.21 ethambutol
embB 4249088 p.Val859Thr missense_variant 0.22 ethambutol
embB 4249102 c.2589T>C synonymous_variant 0.23 ethambutol
embB 4249104 p.Leu864Gln missense_variant 0.23 ethambutol
embB 4249111 c.2598T>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4249126 c.2613G>A synonymous_variant 0.23 ethambutol
embB 4249129 c.2616T>C synonymous_variant 0.23 ethambutol
embB 4249138 c.2625C>G synonymous_variant 0.22 ethambutol
embB 4249158 p.Lys882Thr missense_variant 0.19 ethambutol
embB 4249175 p.Val888Met missense_variant 0.18 ethambutol Uncertain significance
aftB 4267272 p.Lys522Arg missense_variant 1.0 ethambutol Not assoc w R
aftB 4267577 c.1260C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
aftB 4267580 c.1257G>C synonymous_variant 0.19 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.19 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
aftB 4268183 c.654A>T synonymous_variant 0.21 ethambutol
aftB 4268186 c.651C>G synonymous_variant 0.21 ethambutol
aftB 4268194 p.Leu215Val missense_variant 0.22 ethambutol
aftB 4268200 p.Ile213Val missense_variant 0.22 ethambutol
aftB 4268207 c.630C>G synonymous_variant 0.22 ethambutol
aftB 4268213 c.624T>C synonymous_variant 0.22 ethambutol
aftB 4268219 c.618C>G synonymous_variant 0.23 ethambutol
aftB 4268222 c.615G>C synonymous_variant 0.24 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.25 ethambutol
aftB 4268228 c.609C>G synonymous_variant 0.25 ethambutol
aftB 4268233 p.Ile202Val missense_variant 0.24 ethambutol Uncertain significance
aftB 4268236 c.601T>C synonymous_variant 0.23 ethambutol
aftB 4268261 p.Ile192Met missense_variant 0.23 ethambutol
aftB 4268270 c.565_567delTTCinsCG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
aftB 4268282 c.555G>C synonymous_variant 0.19 ethambutol
aftB 4268285 c.552A>G synonymous_variant 0.18 ethambutol
ubiA 4269091 p.Phe248Tyr missense_variant 0.17 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.21 ethambutol
aftB 4269132 c.-296G>C upstream_gene_variant 0.24 ethambutol
ubiA 4269141 c.691_693delTTGinsAC frameshift_variant&missense_variant 0.2 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
ubiA 4269164 p.Leu224Met missense_variant 0.25 ethambutol
aftB 4269177 c.-341G>C upstream_gene_variant 0.23 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.23 ethambutol
aftB 4269210 c.-374G>A upstream_gene_variant 0.21 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.17 ethambutol
aftB 4269231 c.-395C>T upstream_gene_variant 0.17 ethambutol
ethA 4326739 c.735C>G synonymous_variant 0.97 ethionamide Not assoc w R - Interim
ethR 4328004 c.456G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin