TB-Profiler result

Run: SRR12708407
Summary

Run ID: SRR12708407

Sample name:

Date: 2024-04-15T00:40:56.525486

Number of reads: 784485

Percentage reads mapped: 39.95

Median coverage: 21.0

Strain: lineage4.3.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.97
lineage4.3.2 Euro-American (LAM) None 1.0
lineage4.3.2.1 Euro-American (LAM) RD761 0.99
lineage4 Euro-American None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin rrs n.190G>A Mutation from literature
n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472035 n.190G>A non_coding_transcript_exon_variant 0.17 streptomycin Mutation from literature
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5520 p.Pro94Leu missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6205 c.966C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6271 c.1032C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6610 c.-692C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6625 c.-677G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6652 c.-650C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6664 c.1425C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>T upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 c.1510_1512delGCGinsTC frameshift_variant&missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 6764 c.1525_1527delCTGinsTC frameshift_variant&missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.4 levofloxacin
moxifloxacin
gyrB 6802 c.1563G>A synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6850 c.1611C>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7048 c.-254G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>T upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 7210 p.Asp657Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 7222 c.1983C>T synonymous_variant 0.81 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7427 c.126G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7430 c.129G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7475 c.174A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7485 c.184_185delTCinsAG synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7502 c.201C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7643 c.342C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7661 c.360C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7745 c.444G>A synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7763 c.462T>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7853 c.552C>T synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7911 p.Ala204Cys missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 7922 c.621T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 7942 p.Glu214Ala missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 7946 c.645C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7963 p.Gly221Glu missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 7970 c.669T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7979 c.678G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7988 c.687G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7997 c.696A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8024 c.723T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8036 c.735A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8039 c.738T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8048 c.747C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8054 c.753T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8084 c.783G>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8106 c.805C>T synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8121 c.820T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8126 c.825G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8156 c.855T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8184 p.Lys295Arg missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8340 c.1039_1041delGCGinsTC frameshift_variant&missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8393 c.1092T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8480 c.1179C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8510 c.1209G>A synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8513 c.1212C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8535 c.1234_1236delGAGinsCA frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8648 c.1347G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8684 c.1383G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8723 c.1422G>T synonymous_variant 0.34 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8752 p.Ala484Gly missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8774 c.1473C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8813 c.1512C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8816 c.1515C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8825 c.1524G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8840 c.1539C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9068 c.1767G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 9315 c.2014C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.4 levofloxacin
moxifloxacin
mshA 574697 c.-651C>T upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
nusG 734421 c.168A>G synonymous_variant 0.33 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.41 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.44 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.44 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.29 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.34 rifampicin
nusG 734505 c.252G>T synonymous_variant 0.24 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.5 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.4 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.26 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.26 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.36 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.28 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.31 rifampicin Uncertain significance
rpoB 760172 c.366G>C synonymous_variant 0.3 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.36 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760187 c.381G>C synonymous_variant 0.3 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.33 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.28 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.32 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.43 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.35 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.39 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.46 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.47 rifampicin
rpoB 760919 c.1113C>T synonymous_variant 0.53 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.7 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.5 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.64 rifampicin
rpoB 760961 c.1155C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.64 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.59 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>G synonymous_variant 0.53 rifampicin
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.53 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.67 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.62 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.45 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.4 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761885 c.2079T>C synonymous_variant 0.26 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.29 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.27 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.26 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.25 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.32 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.32 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.39 rifampicin Uncertain significance
rpoB 762002 c.2196C>G synonymous_variant 0.35 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.35 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762026 c.2220G>C synonymous_variant 0.44 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.33 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.24 rifampicin
rpoB 762110 c.2304G>C synonymous_variant 0.28 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.41 rifampicin Uncertain significance
rpoB 762119 c.2313C>G synonymous_variant 0.28 rifampicin
rpoB 762128 c.2322G>T synonymous_variant 0.31 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.38 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.3 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.24 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.18 rifampicin
rpoB 762789 p.Leu995Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 762818 c.3012C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.24 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762956 c.-414G>C upstream_gene_variant 0.49 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762971 c.3165G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.33 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.32 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.24 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.43 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.21 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.34 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.21 rifampicin
rpoC 763411 c.42T>C synonymous_variant 0.34 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.35 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.18 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.4 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.53 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.45 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.45 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.48 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.39 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.4 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.37 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.23 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.23 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.22 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.36 rifampicin
rpoC 764039 c.670_671delAGinsTC synonymous_variant 0.38 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.44 rifampicin
rpoC 764059 c.690G>A synonymous_variant 0.43 rifampicin
rpoC 764062 c.693C>G synonymous_variant 0.39 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.39 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764128 c.759C>G synonymous_variant 0.4 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764149 c.780G>C synonymous_variant 0.44 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.38 rifampicin
rpoC 764164 p.Ile265Met missense_variant 0.38 rifampicin
rpoC 764169 p.Asn267Thr missense_variant 0.37 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.35 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.35 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.36 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.36 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.4 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.4 rifampicin
rpoC 764239 c.870T>C synonymous_variant 0.44 rifampicin
rpoC 764254 c.885G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.38 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.31 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.37 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.34 rifampicin
rpoC 764275 c.909_911delACA disruptive_inframe_deletion 0.3 rifampicin
rpoC 764284 c.915delGinsCACC conservative_inframe_insertion&synonymous_variant 0.28 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.38 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.34 rifampicin
rpoC 764383 c.1014C>G synonymous_variant 0.38 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.4 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.64 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.47 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.68 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.67 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.53 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.17 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.41 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.38 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.34 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.34 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.5 rifampicin Not assoc w R
rpoC 764810 c.1441_1443delCCCinsGG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.24 rifampicin
rpoC 764836 c.1467G>A synonymous_variant 0.24 rifampicin
rpoC 764842 c.1473C>T synonymous_variant 0.24 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.22 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.35 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.4 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.63 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.31 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765022 c.1653G>T synonymous_variant 0.25 rifampicin
rpoC 765034 c.1665T>G synonymous_variant 0.21 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.3 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.35 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.33 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.35 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.38 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.39 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.32 rifampicin
rpoC 766960 c.3591C>T synonymous_variant 0.27 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.38 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.28 rifampicin
rpoC 767093 c.3724_3726delAGCinsTCG synonymous_variant 0.24 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.24 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.26 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.22 rifampicin
rpoC 767155 c.3786C>G synonymous_variant 0.21 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781679 c.120C>G synonymous_variant 0.21 streptomycin
rpsL 781682 c.123T>G synonymous_variant 0.21 streptomycin
rpsL 781685 c.126G>C synonymous_variant 0.22 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.29 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.23 streptomycin
rpsL 781709 c.150G>T synonymous_variant 0.23 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.24 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.25 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.41 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.26 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.29 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.3 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.3 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.29 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.31 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.31 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.36 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.31 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.32 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.44 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.59 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.57 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.6 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.59 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.57 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.34 streptomycin
rpsL 781904 c.345C>T synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781907 c.348T>C synonymous_variant 0.55 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.5 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.47 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.24 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.24 linezolid
rplC 800585 c.-224T>A upstream_gene_variant 0.25 linezolid
rplC 800600 c.-209G>A upstream_gene_variant 0.26 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.27 linezolid
rplC 800618 c.-191T>G upstream_gene_variant 0.26 linezolid
rplC 800621 c.-188G>A upstream_gene_variant 0.26 linezolid
rplC 800624 c.-185G>A upstream_gene_variant 0.26 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.26 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.32 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.31 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.31 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.31 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.26 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.24 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.24 linezolid
rplC 800796 c.-13A>C upstream_gene_variant 0.24 linezolid
rplC 800801 c.-8A>G upstream_gene_variant 0.22 linezolid
rplC 800802 c.-6_-5delAG upstream_gene_variant 0.22 linezolid
rplC 800814 c.6A>G synonymous_variant 0.24 linezolid
rplC 800815 c.7C>A synonymous_variant 0.24 linezolid
rplC 800820 c.12G>A synonymous_variant 0.25 linezolid
rplC 800829 c.21C>G synonymous_variant 0.27 linezolid
fbiC 1303545 c.615A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
sigE 1364832 c.420C>G synonymous_variant 0.3 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.35 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.37 pyrazinamide Uncertain significance
atpE 1461149 c.105T>G synonymous_variant 0.35 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.33 bedaquiline
atpE 1461167 c.123G>C synonymous_variant 0.25 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.25 bedaquiline
atpE 1461179 c.135G>A synonymous_variant 0.27 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.27 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.28 bedaquiline
atpE 1461188 c.144G>T synonymous_variant 0.29 bedaquiline
atpE 1461191 c.147G>C synonymous_variant 0.28 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.31 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471984 n.139T>A non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>C non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.37 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472495 n.650C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472720 n.875C>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473653 n.-5T>A upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473707 n.50T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473928 n.271T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474007 n.350A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474016 n.359C>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474018 n.361G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474029 n.372G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474090 n.433C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474104 n.448delT non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474111 n.454_455insC non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474716 n.1059A>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474957 n.1300C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475007 n.1350C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475018 n.1361G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475019 n.1362T>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475337 n.1680C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475404 n.1747A>C non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475422 n.1765A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475606 n.1949T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475622 n.1965G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475635 n.1978G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475761 n.2104_2108delCGCAAinsACTTCG non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476040 n.2383C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867delCinsGA non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476710 n.3053C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476720 n.3063G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
fabG1 1673710 c.271_273delCTAinsGC frameshift_variant&missense_variant 0.46 ethionamide
isoniazid
inhA 1673721 c.-481C>T upstream_gene_variant 0.46 ethionamide
isoniazid
inhA 1673724 c.-478A>G upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1673730 c.-472C>G upstream_gene_variant 0.55 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.55 ethionamide
isoniazid
inhA 1673745 c.-457G>A upstream_gene_variant 0.46 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.46 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.46 ethionamide
isoniazid
fabG1 1673767 p.Asn110Asp missense_variant 0.54 ethionamide
isoniazid
inhA 1673865 c.-337C>G upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.47 ethionamide
isoniazid
inhA 1673916 c.-286A>T upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1673949 c.-253G>A upstream_gene_variant 0.47 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.47 ethionamide
isoniazid
fabG1 1673960 p.Ala174Val missense_variant 0.47 ethionamide
isoniazid
inhA 1673967 c.-235G>C upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1673982 c.-220G>C upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.47 ethionamide
isoniazid
inhA 1673991 c.-211C>T upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.3 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674762 c.561T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674850 c.649C>T synonymous_variant 0.34 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674858 c.657G>A synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674882 c.681G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674904 c.703_705delGCGinsCC frameshift_variant&missense_variant 0.37 ethionamide
isoniazid
inhA 1674909 c.708G>T synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674930 c.729C>T synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674945 p.Asp248Glu missense_variant 0.48 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674963 c.762G>C synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674984 c.783C>T synonymous_variant 0.43 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674987 c.786C>T synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674993 c.792G>T synonymous_variant 0.35 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 0.3 pyrazinamide
rpsA 1833593 c.52_54delTCTinsAC frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1833676 c.135A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.55 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.74 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.59 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.71 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.69 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.46 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.42 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.38 pyrazinamide
rpsA 1833838 c.297G>A synonymous_variant 0.32 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.62 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.64 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.51 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.39 pyrazinamide
rpsA 1834042 c.501G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834090 c.549G>A synonymous_variant 0.21 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.52 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.31 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.29 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.26 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834307 p.Asp256Thr missense_variant 0.22 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.24 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.28 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.41 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.53 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.61 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.34 pyrazinamide Uncertain significance
rpsA 1834573 c.1032G>A synonymous_variant 0.39 pyrazinamide
rpsA 1834574 p.Met345Leu missense_variant 0.41 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834627 c.1086C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.49 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834712 p.Ile391Val missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834732 c.1191T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.3 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834759 c.1218A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834761 p.Phe407Tyr missense_variant 0.27 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.3 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.31 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834788 p.Ala416Gly missense_variant 0.29 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.28 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.25 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.44 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.3 isoniazid
kasA 2518219 c.105T>C synonymous_variant 0.25 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.25 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.29 isoniazid
kasA 2518247 c.133_135delGCAinsAT frameshift_variant&missense_variant 0.29 isoniazid
kasA 2518261 p.Glu49Asp missense_variant 0.3 isoniazid
kasA 2518268 p.Thr52Ser missense_variant 0.29 isoniazid
kasA 2518273 c.159G>A synonymous_variant 0.27 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.21 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.2 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.2 isoniazid
kasA 2518287 p.Val58Ala missense_variant 0.21 isoniazid
kasA 2518312 p.Asp66Glu missense_variant 0.29 isoniazid
kasA 2518323 p.Ser70Ile missense_variant 0.29 isoniazid
kasA 2518339 c.225C>G synonymous_variant 0.23 isoniazid
kasA 2518360 c.246C>T synonymous_variant 0.28 isoniazid
Rv2477c 2782558 c.1485T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782582 c.1459_1461delAACinsGA frameshift_variant&missense_variant 0.41 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782586 p.Leu486Gln missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782603 c.1440G>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782606 c.1437T>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782612 c.1431T>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782636 c.1407G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783632 c.411C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783809 c.234G>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783836 c.207C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783854 c.189C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783857 c.186C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064860 c.1332G>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065064 c.1128G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065070 c.1122C>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCT frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065115 c.1077C>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065118 c.1074C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065126 p.Ser356Ala missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065130 c.1062A>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065133 c.1059T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065166 c.1026C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 0.96 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.24 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626858 c.-245A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.3 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.38 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.37 rifampicin
rpoA 3877908 p.Asn200Ser missense_variant 0.38 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.29 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.27 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.26 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.28 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.25 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.24 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.24 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.3 rifampicin Uncertain significance
rpoA 3878313 c.195G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>C synonymous_variant 0.29 rifampicin
rpoA 3878334 c.174T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878370 c.138T>C synonymous_variant 0.26 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.28 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878764 c.-257A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878767 c.-260G>T upstream_gene_variant 0.32 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.18 rifampicin
rpoA 3879121 c.-614T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.41 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.43 rifampicin
rpoA 3879181 c.-676_-674delAAGinsCGT upstream_gene_variant 0.39 rifampicin
rpoA 3879202 c.-695T>A upstream_gene_variant 0.29 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.82 pyrazinamide Not assoc w R
clpC1 4038740 c.1965G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.5 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.53 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.45 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.45 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.6 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.6 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.75 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.9 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.62 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.44 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.38 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.47 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039010 c.1695G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.57 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039043 c.1662G>T synonymous_variant 0.55 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039439 c.1266C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039552 c.1153C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.42 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Ser missense_variant 0.41 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039646 p.Glu353Asp missense_variant 0.27 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039652 c.1051_1053delACGinsTC frameshift_variant&missense_variant 0.26 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.35 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.54 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.72 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.72 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.72 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.74 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.76 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.56 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.32 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040393 c.312G>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040408 c.297C>A synonymous_variant 0.32 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040429 c.274_276delTTGinsCC frameshift_variant&missense_variant 0.28 pyrazinamide
clpC1 4040435 c.270G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.51 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040537 c.168G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040540 c.165G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040549 c.154_156delTTGinsCC frameshift_variant&missense_variant 0.29 pyrazinamide
clpC1 4040561 c.144A>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
glpK 4138429 c.1327T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138457 c.1299C>T synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138460 c.1296C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138463 c.1293C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1264_1266delGTGinsAC frameshift_variant&missense_variant 0.37 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138495 p.Gln421Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138505 c.1251T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138532 c.1224G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139189 c.567G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139195 c.561G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139198 c.558C>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139228 c.528G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139242 c.514T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139252 c.502_504delAACinsCG frameshift_variant&missense_variant 0.34 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139267 c.489C>A synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139270 c.486C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139273 c.483A>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139276 c.480T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139285 c.471A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139290 c.466C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139312 c.444T>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139318 c.438T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139321 c.435T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139324 c.432A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139336 c.420C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139648 c.108T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139652 p.His35Gly missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240780 c.918T>C synonymous_variant 0.37 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.37 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.35 ethambutol
embC 4240795 c.933C>G synonymous_variant 0.33 ethambutol
embC 4241084 c.1222C>T synonymous_variant 0.41 ethambutol
embC 4241101 c.1239G>T synonymous_variant 0.43 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.5 ethambutol
embC 4241119 c.1257C>G synonymous_variant 0.48 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.39 ethambutol
embC 4241140 c.1278A>C synonymous_variant 0.39 ethambutol
embC 4241141 p.Ile427Ala missense_variant 0.39 ethambutol
embC 4241146 c.1284C>G synonymous_variant 0.41 ethambutol
embC 4241161 c.1299C>A synonymous_variant 0.41 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.41 ethambutol
embC 4241168 c.1306C>T synonymous_variant 0.43 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R