TB-Profiler result

Run: SRR7240033
Summary

Run ID: SRR7240033

Sample name:

Date: 2024-04-16T03:57:46.653074

Number of reads: 1151989

Percentage reads mapped: 57.12

Median coverage: 47.0

Strain: La1.2;La1.8.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8 M.bovis None 1.0
La1.8.1 M.bovis None 1.0
La1.2 M.bovis None 0.05
La1 M.bovis None 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.469_471delCAGinsGA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303399 c.469_471delCAGinsGA frameshift_variant&missense_variant 0.2 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.41 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
dnaA 877 c.877T>C synonymous_variant 0.25 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.25 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.25 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.28 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.29 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.29 isoniazid
dnaA 927 c.927G>A synonymous_variant 0.28 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.27 isoniazid
dnaA 942 c.942C>T synonymous_variant 0.26 isoniazid
dnaA 948 p.Asp316Glu missense_variant 0.23 isoniazid
dnaA 955 c.955_957delAGAinsCC frameshift_variant&missense_variant 0.21 isoniazid Uncertain significance
dnaA 963 c.963C>G synonymous_variant 0.21 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.21 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.21 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.2 isoniazid
dnaA 1254 c.1254T>C synonymous_variant 0.23 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.24 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.24 isoniazid
dnaA 1291 c.1291_1293delCTTinsTG frameshift_variant&missense_variant 0.25 isoniazid Uncertain significance
dnaA 1302 c.1302C>G synonymous_variant 0.23 isoniazid
dnaA 1305 c.1305C>T synonymous_variant 0.23 isoniazid
dnaA 1309 c.1309_1311delACCinsTG frameshift_variant&missense_variant 0.23 isoniazid Uncertain significance
dnaA 1314 c.1314A>G synonymous_variant 0.22 isoniazid
dnaA 1326 c.1326G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1327 c.1327_1329delTCAinsCG frameshift_variant&missense_variant 0.19 isoniazid Uncertain significance
dnaA 1332 c.1332A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.19 isoniazid
dnaA 1341 c.1341G>C synonymous_variant 0.19 isoniazid
dnaA 1347 c.1347C>T synonymous_variant 0.18 isoniazid
dnaA 1359 c.1359G>A synonymous_variant 0.18 isoniazid Not assoc w R - Interim
gyrB 5752 c.513G>A synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6170 p.His311Ala missense_variant 0.32 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6196 c.957C>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6208 c.969G>A synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6214 c.975G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6229 c.990G>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrB 6236 p.Lys333Arg missense_variant 0.41 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6244 c.1005C>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6247 c.1008G>A synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6266 p.Pro343Ser missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6286 c.1047T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6325 c.-977C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6346 c.-956C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6649 c.-653T>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6663 p.Phe475Tyr missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 6667 c.-635G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6722 c.-580C>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7415 c.114C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7421 c.120G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7460 c.159C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7463 c.162G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7605 p.Pro102Ser missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7614 p.Leu105Met missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7853 c.552C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7889 c.588G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7906 p.Phe202Tyr missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7922 c.621T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7923 p.His208Phe missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7937 c.636A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7942 p.Glu214Ala missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7949 c.648G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8252 p.Glu317Asp missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin
gyrA 8253 p.Ile318Val missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8273 c.972C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8274 p.Lys325Arg missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCT frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8408 c.1107A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8495 c.1194C>T synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8556 p.Ala419Gln missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8570 p.Glu423Asp missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8585 c.1284C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8588 p.Glu429Asp missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8651 c.1350C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8723 c.1422G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8769 p.His490Tyr missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8897 c.1596T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8948 p.Leu549Phe missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9134 c.1833C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9145 p.Arg615Gln missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9164 c.1863G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9197 c.1896G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9217 p.Asp639Ala missense_variant 0.7 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9224 c.1923C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9267 p.Asn656Gly missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9288 p.Val663Met missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9368 c.2067G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491542 c.760T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575708 p.Asp121Asn missense_variant 0.3 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.29 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.3 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.34 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.32 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.34 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575806 c.459G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575818 c.471G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.32 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.26 ethionamide
isoniazid
ccsA 620208 c.318G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620247 p.Leu119Phe missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620257 c.367_369delATCinsGG frameshift_variant&missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620264 p.Gly125Ala missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620271 c.381C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620275 c.385C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>G synonymous_variant 0.2 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620284 c.394_396delGCGinsCA frameshift_variant&missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620289 c.399A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620291 p.Tyr134Phe missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620296 p.Pro136Ser missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620311 p.Leu141Val missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620319 c.429C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620338 p.Thr150Ala missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620341 p.Val151Met missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620351 p.Arg154His missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
hadA 731816 c.-114G>C upstream_gene_variant 0.25 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.25 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.2 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.28 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.35 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.32 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.37 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.36 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.36 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.35 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.37 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.34 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>C synonymous_variant 0.36 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.39 rifampicin
nusG 734616 c.363C>G synonymous_variant 0.31 rifampicin
nusG 734619 c.366G>C synonymous_variant 0.31 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.31 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.3 rifampicin
nusG 734637 c.384G>T synonymous_variant 0.26 rifampicin
rpoB 760059 p.Tyr85Asp missense_variant 0.21 rifampicin
rpoB 760070 c.264T>C synonymous_variant 0.24 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760092 p.Ser96Thr missense_variant 0.26 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.3 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.33 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760130 c.324T>C synonymous_variant 0.35 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.35 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.36 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.48 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760208 p.Ile134Met missense_variant 0.54 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.54 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.62 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.59 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.58 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.57 rifampicin
rpoB 760323 c.517C>T synonymous_variant 0.58 rifampicin
rpoB 760328 c.522G>T synonymous_variant 0.57 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.58 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.58 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.58 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.58 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760367 c.561G>A synonymous_variant 0.57 rifampicin
rpoB 760370 c.564C>G synonymous_variant 0.57 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.56 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.55 rifampicin
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.52 rifampicin
rpoB 760394 c.588C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>G synonymous_variant 0.52 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760485 p.Pro227Ser missense_variant 0.43 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.35 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.36 rifampicin Uncertain significance
rpoB 760530 c.724_726delATTinsGC frameshift_variant&missense_variant 0.33 rifampicin
rpoB 760533 p.Val243Arg missense_variant 0.33 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.39 rifampicin Uncertain significance
rpoB 760568 c.762G>C synonymous_variant 0.39 rifampicin
rpoB 760584 p.Asn260Ser missense_variant 0.36 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.38 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.38 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760616 p.Asp270Glu missense_variant 0.39 rifampicin Uncertain significance
rpoB 760643 c.837G>A synonymous_variant 0.38 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760697 p.Glu297Asp missense_variant 0.25 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Val missense_variant 0.27 rifampicin
rpoB 760858 p.Val351Ala missense_variant 0.3 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Phe missense_variant 0.34 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.33 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.33 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.33 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.45 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.49 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>G synonymous_variant 0.49 rifampicin
rpoB 760938 c.1132C>T synonymous_variant 0.48 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.51 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.49 rifampicin
rpoB 760988 c.1182C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.52 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>A synonymous_variant 0.49 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.48 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.48 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761174 c.1368T>G synonymous_variant 0.48 rifampicin
rpoB 761177 c.1371G>C synonymous_variant 0.46 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.48 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.5 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.51 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.48 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.44 rifampicin
rpoB 761300 c.1494G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761312 c.1506G>C synonymous_variant 0.38 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>C synonymous_variant 0.42 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.42 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.38 rifampicin
rpoB 761370 c.1564_1566delATCinsGG frameshift_variant&missense_variant 0.37 rifampicin
rpoB 761373 p.Val523Gln missense_variant 0.34 rifampicin
rpoB 761396 c.1590G>A synonymous_variant 0.34 rifampicin
rpoB 761403 p.His533Tyr missense_variant 0.31 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.25 rifampicin
rpoB 761430 c.1624_1626delATCinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.22 rifampicin
rpoB 761437 p.Ala544Asp missense_variant 0.22 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.23 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.22 rifampicin
rpoB 761451 p.Val549Ser missense_variant 0.22 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.22 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.25 rifampicin
rpoB 761477 c.1671C>T synonymous_variant 0.24 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.24 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.24 rifampicin
rpoB 761501 c.1695G>C synonymous_variant 0.22 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.22 rifampicin
rpoB 761507 c.1701G>C synonymous_variant 0.21 rifampicin
rpoB 761508 c.1702_1704delTCTinsGG frameshift_variant&missense_variant 0.21 rifampicin
rpoB 761511 p.Glu569Gln missense_variant 0.21 rifampicin
rpoB 761519 p.Asp571Glu missense_variant 0.29 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.32 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.28 rifampicin
rpoB 761615 c.1809A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.21 rifampicin
rpoB 761655 c.1849_1851delGCCinsTG frameshift_variant&missense_variant 0.21 rifampicin
rpoB 761669 c.1863C>G synonymous_variant 0.22 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.21 rifampicin
rpoB 761687 c.1881C>G synonymous_variant 0.19 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.19 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.4 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762078 c.2272C>T synonymous_variant 0.47 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.51 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.51 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.42 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.44 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.42 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.42 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>G synonymous_variant 0.42 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.43 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.42 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.43 rifampicin
rpoB 762368 c.2562G>A synonymous_variant 0.43 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.43 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.42 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.41 rifampicin
rpoC 762390 c.-980C>T upstream_gene_variant 0.39 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.36 rifampicin
rpoC 762398 c.-972T>G upstream_gene_variant 0.36 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.34 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.37 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.38 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.4 rifampicin
rpoC 762467 c.-903C>T upstream_gene_variant 0.37 rifampicin
rpoB 762485 c.2679G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762486 p.Pro894Ala missense_variant 0.3 rifampicin
rpoB 762489 p.Val895Thr missense_variant 0.29 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.32 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 762518 c.-852C>G upstream_gene_variant 0.31 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.29 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.24 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.24 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.24 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.25 rifampicin
rpoC 762575 c.-795C>T upstream_gene_variant 0.2 rifampicin
rpoB 762725 c.2919C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762736 p.Ala977Glu missense_variant 0.2 rifampicin
rpoB 762749 c.2943C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762753 c.2947T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762756 c.2950_2952delTCGinsGC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 762760 p.Cys985Ser missense_variant 0.24 rifampicin Uncertain significance
rpoB 762771 p.Asn989Asp missense_variant 0.29 rifampicin
rpoC 762776 c.-594C>G upstream_gene_variant 0.3 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762783 p.Asp993Asn missense_variant 0.3 rifampicin
rpoB 762795 p.Asp997Asn missense_variant 0.4 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.39 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.48 rifampicin
rpoB 762820 p.Phe1005Tyr missense_variant 0.5 rifampicin
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.76 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.72 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.28 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.68 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.66 rifampicin
rpoC 763082 c.-288C>G upstream_gene_variant 0.65 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.6 rifampicin
rpoC 763115 c.-255T>G upstream_gene_variant 0.59 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.56 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.52 rifampicin
rpoB 763145 c.3339G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.48 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.36 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.37 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.35 rifampicin
rpoC 763220 c.-150G>C upstream_gene_variant 0.35 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.29 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763247 p.Glu1147Asp missense_variant 0.21 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.2 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.25 rifampicin
rpoC 763420 c.51G>C synonymous_variant 0.26 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.26 rifampicin Uncertain significance
rpoC 763430 c.61A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.32 rifampicin
rpoC 763453 c.84C>G synonymous_variant 0.34 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763489 c.120G>A synonymous_variant 0.4 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763597 c.228G>A synonymous_variant 0.52 rifampicin
rpoC 763606 c.237C>T synonymous_variant 0.52 rifampicin
rpoC 763609 c.240C>G synonymous_variant 0.53 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.5 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.5 rifampicin
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.52 rifampicin
rpoC 763666 c.297G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.52 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.5 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.54 rifampicin
rpoC 763781 p.Ser138Gly missense_variant 0.49 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.47 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763810 c.441G>A synonymous_variant 0.44 rifampicin
rpoC 763813 c.444C>G synonymous_variant 0.41 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.41 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763831 c.462A>G synonymous_variant 0.4 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.38 rifampicin
rpoC 763844 p.Arg159Lys missense_variant 0.37 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.4 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.36 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.36 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.34 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.34 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.33 rifampicin
rpoC 763960 c.591T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.3 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.28 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.27 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.27 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>G synonymous_variant 0.28 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.28 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.27 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.29 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.34 rifampicin
rpoC 764060 p.Pro231Ile missense_variant 0.33 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.38 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.44 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.45 rifampicin Uncertain significance
rpoC 764194 p.Glu275Asp missense_variant 0.49 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.49 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Thr missense_variant 0.49 rifampicin Uncertain significance
rpoC 764213 p.Arg282Lys missense_variant 0.49 rifampicin Uncertain significance
rpoC 764236 c.867G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.51 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.51 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.52 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764347 c.978G>C synonymous_variant 0.5 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.43 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.43 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764443 p.Ile358Met missense_variant 0.56 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.53 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.52 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.51 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764656 c.1287C>G synonymous_variant 0.56 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.54 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.57 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.57 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.56 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.43 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.39 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.41 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.38 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.37 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.4 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.36 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.34 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.3 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 765070 c.1701G>C synonymous_variant 0.25 rifampicin
rpoC 765076 c.1707A>G synonymous_variant 0.26 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765121 c.1752G>T synonymous_variant 0.24 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.19 rifampicin
rpoC 765398 c.2029C>T synonymous_variant 0.18 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.19 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.24 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.24 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.31 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.39 rifampicin
rpoC 765544 c.2175C>G synonymous_variant 0.45 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2180delAGinsTC synonymous_variant 0.45 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.45 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.45 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.46 rifampicin
rpoC 765611 p.His748Ala missense_variant 0.55 rifampicin
rpoC 765621 p.Glu751Ala missense_variant 0.56 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765637 c.2268C>G synonymous_variant 0.57 rifampicin
rpoC 765640 c.2271A>G synonymous_variant 0.57 rifampicin
rpoC 765661 c.2292T>C synonymous_variant 0.56 rifampicin
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 765669 p.His767Arg missense_variant 0.58 rifampicin
rpoC 765681 p.Asn771Thr missense_variant 0.6 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Glu missense_variant 0.63 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765742 p.Glu791Asp missense_variant 0.65 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.66 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.66 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.66 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.67 rifampicin
rpoC 765781 p.Asp804Glu missense_variant 0.67 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.68 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.67 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.66 rifampicin
rpoC 765826 c.2457T>G synonymous_variant 0.66 rifampicin
rpoC 765850 c.2481G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.57 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.56 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765898 c.2529C>T synonymous_variant 0.55 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.48 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>G synonymous_variant 0.49 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593T>C synonymous_variant 0.48 rifampicin
rpoC 765967 c.2598C>G synonymous_variant 0.47 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.31 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.29 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.27 rifampicin
rpoC 766043 p.Gln892Gly missense_variant 0.19 rifampicin
rpoC 766051 c.2682G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766054 c.2685C>G synonymous_variant 0.19 rifampicin
rpoC 766061 p.Val898Thr missense_variant 0.2 rifampicin
rpoC 766066 c.2697C>G synonymous_variant 0.19 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.22 rifampicin
rpoC 766087 c.2718C>G synonymous_variant 0.22 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.22 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.22 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.23 rifampicin
rpoC 766298 p.Thr977Leu missense_variant 0.26 rifampicin
rpoC 766312 c.2943T>C synonymous_variant 0.41 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.42 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.44 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.52 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.59 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.59 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.61 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.62 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.59 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.54 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.45 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.45 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766517 p.Thr1050Ser missense_variant 0.5 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.48 rifampicin
rpoC 766525 c.3156G>C synonymous_variant 0.48 rifampicin
rpoC 766526 c.3157_3159delGTTinsAC frameshift_variant&missense_variant 0.48 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.51 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.52 rifampicin
rpoC 766542 p.Gly1058Asp missense_variant 0.51 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.47 rifampicin
rpoC 766568 c.3199_3201delGTTinsAC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.47 rifampicin
rpoC 766582 c.3213C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766592 p.Val1075Leu missense_variant 0.51 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.51 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.53 rifampicin
rpoC 766628 p.Arg1087Lys missense_variant 0.48 rifampicin
rpoC 766644 p.Glu1092Ala missense_variant 0.42 rifampicin
rpoC 766652 p.Ser1095Glu missense_variant 0.4 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.39 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.39 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.4 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.4 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.42 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.5 rifampicin
rpoC 766703 p.Met1112Leu missense_variant 0.52 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.52 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.51 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.51 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.54 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.52 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.52 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766813 c.3444G>C synonymous_variant 0.58 rifampicin
rpoC 766843 c.3474T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766879 c.3510G>C synonymous_variant 0.63 rifampicin
rpoC 766882 c.3513C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>C synonymous_variant 0.62 rifampicin
rpoC 766888 c.3519G>C synonymous_variant 0.62 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.63 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.63 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.64 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.62 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.64 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.65 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.65 rifampicin
rpoC 766931 c.3562_3564delGCAinsTG frameshift_variant&stop_gained 0.6 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766949 p.Val1194Met missense_variant 0.57 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.55 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.55 rifampicin
rpoC 766996 c.3627C>G synonymous_variant 0.54 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>G synonymous_variant 0.51 rifampicin
rpoC 767068 c.3699G>C synonymous_variant 0.53 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.54 rifampicin
rpoC 767095 c.3726C>T synonymous_variant 0.49 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767099 p.Lys1244Arg missense_variant 0.47 rifampicin
rpoC 767105 c.3736_3738delAACinsGG frameshift_variant&missense_variant 0.45 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.46 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775939 p.Ala848Ser missense_variant 0.18 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.19 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781676 c.117C>G synonymous_variant 0.22 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.24 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.22 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.2 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.2 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.2 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.2 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.2 streptomycin
rpsL 781737 c.179_180delAG frameshift_variant 0.2 streptomycin Uncertain significance
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.24 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.28 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.29 streptomycin
rpsL 781808 c.249C>G synonymous_variant 0.4 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.37 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781862 c.303G>C synonymous_variant 0.35 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.34 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.34 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.34 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.36 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.37 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.38 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.37 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.39 streptomycin Uncertain significance
rplC 800543 c.-266C>T upstream_gene_variant 0.26 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.25 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.24 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.23 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.24 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.24 linezolid
rplC 800585 c.-224T>A upstream_gene_variant 0.24 linezolid
rplC 800590 c.-219G>A upstream_gene_variant 0.23 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.23 linezolid
rplC 800597 c.-212A>T upstream_gene_variant 0.22 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.22 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.23 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.23 linezolid
rplC 800628 c.-181_-179delGTGinsAC upstream_gene_variant 0.22 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.21 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.22 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.26 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.26 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.26 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.19 linezolid
rplC 800726 c.-83G>C upstream_gene_variant 0.19 linezolid
rplC 800732 c.-77G>A upstream_gene_variant 0.18 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.2 linezolid
rplC 800753 c.-56C>T upstream_gene_variant 0.21 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.19 linezolid
rplC 800829 c.21C>G synonymous_variant 0.2 linezolid
rplC 800832 c.24T>C synonymous_variant 0.2 linezolid
rplC 800844 c.36T>A synonymous_variant 0.25 linezolid
rplC 800856 c.48A>G synonymous_variant 0.26 linezolid
rplC 800865 c.57A>G synonymous_variant 0.27 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.29 linezolid
rplC 800872 c.64_66delAGAinsCG frameshift_variant&synonymous_variant 0.27 linezolid
rplC 800877 c.69A>C synonymous_variant 0.27 linezolid
rplC 800880 c.72A>T synonymous_variant 0.28 linezolid
rplC 800898 c.90G>A synonymous_variant 0.33 linezolid
rplC 800904 c.96G>T synonymous_variant 0.36 linezolid
rplC 800907 c.99C>G synonymous_variant 0.36 linezolid
rplC 800913 c.105G>C synonymous_variant 0.36 linezolid
rplC 800916 c.108A>G synonymous_variant 0.36 linezolid
rplC 800937 c.129A>G synonymous_variant 0.33 linezolid
rplC 801205 p.Arg133Ala missense_variant 0.31 linezolid
rplC 801210 c.402T>C synonymous_variant 0.33 linezolid
rplC 801222 c.414T>C synonymous_variant 0.31 linezolid
rplC 801228 c.420T>C synonymous_variant 0.3 linezolid
rplC 801229 p.Ala141Thr missense_variant 0.28 linezolid
rplC 801249 c.441T>C synonymous_variant 0.27 linezolid
rplC 801252 c.444G>C synonymous_variant 0.28 linezolid
rplC 801267 c.459A>C synonymous_variant 0.3 linezolid
rplC 801270 c.462T>C synonymous_variant 0.29 linezolid
rplC 801276 c.468G>C synonymous_variant 0.33 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.36 linezolid
rplC 801288 c.480G>C synonymous_variant 0.33 linezolid
rplC 801309 c.501C>G synonymous_variant 0.33 linezolid
rplC 801312 c.504G>C synonymous_variant 0.33 linezolid
rplC 801324 c.516T>C synonymous_variant 0.28 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303323 c.393T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303332 c.402A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303335 c.405T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303342 p.Phe138Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303347 c.417T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303362 c.432A>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303368 c.438T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303374 c.444T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303380 c.450T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303383 c.453G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303386 c.456G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303392 c.462T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303397 p.Arg156Pro missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303404 c.474A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303407 c.477C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303408 p.Glu160Gln missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303418 p.Gly163Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303425 c.495G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303431 c.501T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303440 c.510G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303441 c.511T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303464 c.534A>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303538 p.Arg203Leu missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303548 c.618G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303689 c.759T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304532 c.1602G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304572 p.Val548Ile missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304608 p.Thr560Val missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304637 c.1707G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304660 p.Tyr577Phe missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304664 c.1734G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304698 p.Glu590Gln missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304718 c.1788C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304736 c.1806G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304798 p.Ala623Asp missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304826 c.1896G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304845 p.Ala639Thr missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304934 c.2004C>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304967 c.2037G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>T non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472288 n.443A>C non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>A non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472325 n.480G>T non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472326 n.481T>G non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444_1445delTCinsGTAA non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473677 n.20C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473937 n.280C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473941 n.284T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473965 n.308G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473968 n.311C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473981 n.325_328delGATA non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473989 n.332_333insGTG non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473992 n.335A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473994 n.337C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473995 n.338_339insT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474001 n.344_345delCGinsTCA non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474003 n.346G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474007 n.350A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474008 n.351G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474016 n.359C>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474026 n.369C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474105 n.448T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474106 n.449A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474107 n.450T>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474109 n.452A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1474290 n.633_644delTTTTCCTCTCCGinsCCC non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474302 n.645G>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474306 n.649A>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474381 n.724T>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474505 n.848C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474623 n.968_969insCACGTGT non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474632 n.975G>C non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474633 n.977_983delTCACCGC non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474710 n.1053delTinsGCAC non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474712 n.1055G>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474952 n.1296delC non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474971 n.1314T>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474972 n.1316dupT non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475005 n.1348C>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475008 n.1351C>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475010 n.1353G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475015 n.1358C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475017 n.1360_1363delGGTGinsTAGCT non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475029 n.1372T>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475030 n.1373G>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475217 n.1560T>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475243 n.1586G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475247 n.1592_1594delTCA non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475254 n.1597delCinsTGAT non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475265 n.1608G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475266 n.1609T>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475268 n.1611T>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475275 n.1618C>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475374 n.1717_1718insAC non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475379 n.1722G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475381 n.1724_1726delGATinsC non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475404 n.1747_1748delAAinsTAAG non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475408 n.1752delT non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475586 n.1929C>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475606 n.1949T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475616 n.1959A>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475618 n.1961C>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475620 n.1963T>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475622 n.1966_1967insCC non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475625 n.1969delT non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsGTGGAAGCAATT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475763 n.2107_2112delAAGGGT non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476085 n.2428G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>C non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476691 n.3034T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
inhA 1673580 c.-622T>G upstream_gene_variant 0.21 ethionamide
isoniazid Uncertain significance
inhA 1673583 c.-619A>T upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673589 c.-613A>T upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.2 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.2 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673610 c.-592C>G upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1673615 p.Glu59Val missense_variant 0.18 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.18 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.18 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.28 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673688 c.-514G>A upstream_gene_variant 0.28 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.3 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.29 ethionamide
isoniazid
inhA 1673724 c.-478A>C upstream_gene_variant 0.31 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673730 c.-472C>G upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.32 ethionamide
isoniazid
inhA 1673757 c.-445G>A upstream_gene_variant 0.3 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.29 ethionamide
isoniazid
inhA 1673778 c.-424C>G upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673796 c.-406G>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673797 c.358_360delGCTinsAC frameshift_variant&missense_variant 0.24 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673805 c.-397G>C upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673808 c.-394A>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673829 p.Asn130Lys missense_variant 0.23 ethionamide
isoniazid
fabG1 1673830 p.Lys131Arg missense_variant 0.23 ethionamide
isoniazid
inhA 1673838 c.-364T>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1673841 c.-361A>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673844 p.Met135Ile missense_variant 0.24 ethionamide
isoniazid
inhA 1673847 c.-355A>C upstream_gene_variant 0.21 ethionamide
isoniazid
fabG1 1673849 p.Phe137Tyr missense_variant 0.21 ethionamide
isoniazid
inhA 1673853 c.-349A>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673856 c.-346T>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673865 c.-337C>G upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673870 p.Ser144Met missense_variant 0.23 ethionamide
isoniazid
inhA 1673877 c.-325C>G upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673901 c.-301A>C upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.25 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.23 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1673937 c.-265G>C upstream_gene_variant 0.21 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.19 ethionamide
isoniazid
inhA 1673949 c.-253G>A upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673979 c.-223G>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673985 c.-217C>A upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674353 p.Thr51Ile missense_variant 0.18 ethionamide
isoniazid
inhA 1674375 c.174C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674384 c.183C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674387 c.186A>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674399 c.198A>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674405 p.Glu68Asp missense_variant 0.22 ethionamide
isoniazid
inhA 1674414 c.213G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674416 p.Ala72Asp missense_variant 0.21 ethionamide
isoniazid
inhA 1674418 c.217_218delAGinsTC synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674421 c.220T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674428 p.Gly76Asp missense_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674433 c.232_234delGTGinsAC frameshift_variant&missense_variant 0.22 ethionamide
isoniazid
inhA 1674443 p.Ala81Val missense_variant 0.28 ethionamide
isoniazid
inhA 1674450 c.249G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674455 p.Gly85Asp missense_variant 0.29 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674503 p.Thr101Ser missense_variant 0.31 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674513 c.312C>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.27 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.28 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674542 p.Ala114Glu missense_variant 0.28 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.28 ethionamide
isoniazid
inhA 1674558 c.357C>A synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674573 c.372G>C synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674585 c.384T>G synonymous_variant 0.39 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.38 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.4 ethionamide
isoniazid
inhA 1674610 c.409_411delATCinsGG frameshift_variant&missense_variant 0.4 ethionamide
isoniazid
inhA 1674620 p.Pro140Arg missense_variant 0.38 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.43 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674737 p.Ala179Val missense_variant 0.33 ethionamide
isoniazid
inhA 1674742 p.Lys181Ala missense_variant 0.32 ethionamide
isoniazid
inhA 1674745 p.Tyr182His missense_variant 0.31 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674750 c.549T>G synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674762 c.561T>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674765 c.564C>G synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674768 c.567T>G synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674774 c.573A>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674786 c.585G>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674819 c.618G>C synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674825 c.624C>T synonymous_variant 0.32 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674828 p.Glu209Asp missense_variant 0.26 ethionamide
isoniazid
inhA 1674837 c.636C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674839 p.Ala213Glu missense_variant 0.29 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.29 ethionamide
isoniazid
inhA 1674847 p.Gln216Lys missense_variant 0.29 ethionamide
isoniazid
inhA 1674850 c.649C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674855 c.654C>G synonymous_variant 0.33 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674883 c.682_684delATCinsGG frameshift_variant&missense_variant 0.41 ethionamide
isoniazid
inhA 1674892 p.Asn231Asp missense_variant 0.42 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.33 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1675002 c.801A>G synonymous_variant 0.35 ethionamide
isoniazid
rpsA 1833250 c.-292A>G upstream_gene_variant 0.4 pyrazinamide
rpsA 1833251 c.-291A>G upstream_gene_variant 0.4 pyrazinamide
rpsA 1833257 c.-285_-284delCCinsGA upstream_gene_variant 0.4 pyrazinamide
rpsA 1833262 c.-280T>C upstream_gene_variant 0.39 pyrazinamide
rpsA 1833273 c.-269G>A upstream_gene_variant 0.4 pyrazinamide
rpsA 1833277 c.-265C>G upstream_gene_variant 0.4 pyrazinamide
rpsA 1833283 c.-259C>G upstream_gene_variant 0.39 pyrazinamide
rpsA 1833289 c.-253G>A upstream_gene_variant 0.38 pyrazinamide
rpsA 1833295 c.-247C>G upstream_gene_variant 0.37 pyrazinamide
rpsA 1833296 c.-246A>C upstream_gene_variant 0.36 pyrazinamide
rpsA 1833310 c.-232T>C upstream_gene_variant 0.36 pyrazinamide
rpsA 1833325 c.-217C>A upstream_gene_variant 0.28 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.25 pyrazinamide
rpsA 1833554 p.Thr5Ser missense_variant 0.25 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.28 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.27 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.27 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833610 c.69C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.33 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.34 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1833664 c.123C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.49 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.5 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.55 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.58 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.56 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.57 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.62 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.61 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.6 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.61 pyrazinamide
rpsA 1833806 c.265C>T synonymous_variant 0.6 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.6 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.59 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.64 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.61 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.63 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.63 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.6 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.59 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.6 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.63 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.6 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.6 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834154 p.Asn205His missense_variant 0.5 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.51 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.52 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.51 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.52 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834241 c.700C>T synonymous_variant 0.52 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834288 c.747C>G synonymous_variant 0.59 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.64 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.66 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.67 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.66 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.71 pyrazinamide
rpsA 1834527 p.Arg329Gln missense_variant 0.69 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834556 c.1015_1017delGCCinsTG frameshift_variant&missense_variant 0.69 pyrazinamide Uncertain significance
rpsA 1834573 c.1032G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834579 c.1038C>G synonymous_variant 0.68 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.64 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.63 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.63 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.63 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.65 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.56 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834733 c.1192_1194delGCCinsCG frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834738 c.1197A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAG frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834756 c.1215G>A synonymous_variant 0.29 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.31 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.31 pyrazinamide
rpsA 1834767 p.Lys409Thr missense_variant 0.31 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834813 c.1272G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1853361 c.-245T>C upstream_gene_variant 0.47 linezolid
tsnR 1853370 c.-236_-234delGCAinsTC upstream_gene_variant 0.46 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.46 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 0.48 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.48 linezolid
tsnR 1853393 c.-213C>G upstream_gene_variant 0.48 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.48 linezolid
tsnR 1853420 c.-186T>C upstream_gene_variant 0.47 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.44 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.42 linezolid
tsnR 1853444 c.-162C>G upstream_gene_variant 0.34 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.33 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.28 linezolid
tsnR 1853468 c.-138C>G upstream_gene_variant 0.24 linezolid
tsnR 1853471 c.-135C>G upstream_gene_variant 0.24 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.24 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.22 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.21 linezolid
tsnR 1853493 c.-113_-112delGCinsCA upstream_gene_variant 0.24 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.26 isoniazid
kasA 2517968 c.-147T>G upstream_gene_variant 0.2 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.18 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.17 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.2 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.2 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.2 isoniazid
kasA 2518573 c.459G>C synonymous_variant 0.2 isoniazid
kasA 2518574 p.Ile154Ala missense_variant 0.21 isoniazid
kasA 2518579 c.465T>G synonymous_variant 0.2 isoniazid
kasA 2518585 c.471G>A synonymous_variant 0.2 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.2 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.21 isoniazid
kasA 2518597 c.483C>T synonymous_variant 0.26 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.29 isoniazid
kasA 2518612 c.498C>G synonymous_variant 0.3 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.34 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.31 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.33 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.34 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.36 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.33 isoniazid
kasA 2518688 p.Val192Ile missense_variant 0.33 isoniazid
kasA 2518692 p.Ala193Val missense_variant 0.33 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.36 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.44 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.42 isoniazid
kasA 2518726 c.612G>A synonymous_variant 0.44 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.43 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.43 isoniazid
kasA 2518756 c.642G>T synonymous_variant 0.41 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.41 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.27 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.24 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.25 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.24 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.24 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.26 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.23 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.23 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.22 isoniazid
eis 2714276 p.Arg353Trp missense_variant 1.0 amikacin
kanamycin
eis 2715125 p.Thr70Ala missense_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
ahpC 2726657 c.465A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
Rv2477c 2782900 c.1143C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782924 c.1119G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782930 c.1113G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782956 c.1087C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782966 c.1077C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782987 c.1056C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783077 c.966T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783141 p.Thr301Asn missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.26 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783152 c.891G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783173 c.870C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783177 p.Gln289Ala missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783206 c.837G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783218 c.825C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783239 p.Glu268Asp missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783248 c.795G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783251 c.792G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783260 c.783G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 p.Glu250Asp missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783427 p.Pro206Ala missense_variant 0.42 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.57 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 c.475_477delAACinsCG frameshift_variant&missense_variant 0.44 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783572 c.471A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 c.465G>A synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783602 c.441G>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783623 c.420G>A synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.55 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783634 p.Leu137Ile missense_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783646 p.Asp133Asn missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783653 c.390C>T synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783668 c.375G>T synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783764 c.277_279delATGinsCC frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783773 c.270A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783788 c.255T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783806 c.237G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783872 c.171G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 c.168G>A synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783881 c.160_162delTTGinsCC frameshift_variant&missense_variant 0.43 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783884 c.159T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783896 c.147G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783901 c.142T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783908 c.135G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783950 c.93C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783957 p.Tyr29Leu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783968 c.75G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783983 c.58_60delATCinsGG frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783986 c.57G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783989 c.54G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784001 c.42G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784032 p.Phe4Tyr missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784034 c.9G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784037 c.6T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2995832 c.-273G>A upstream_gene_variant 1.0 capreomycin
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
thyA 3073874 p.Ile200Val missense_variant 0.26 para-aminosalicylic_acid
thyA 3073888 p.Ser195Lys missense_variant 0.26 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073926 c.546G>A synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073998 p.Arg158Thr missense_variant 0.25 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074025 p.Phe149Leu missense_variant 0.18 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3612697 c.420G>A synonymous_variant 1.0 pyrazinamide
lpqB 3623372 c.1539G>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625117 c.1495_1497delCTTinsTG frameshift_variant&synonymous_variant 0.25 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625123 c.-213T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625141 c.-231T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.27 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625168 c.-258G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625246 c.-336G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625255 c.-345T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625263 p.Tyr451His missense_variant 0.24 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Gln missense_variant 0.18 bedaquiline
rifampicin
lpqB 3625327 c.-417A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625571 p.Thr348Leu missense_variant 0.2 bedaquiline
rifampicin
lpqB 3625573 c.-663G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625585 c.-675G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625588 c.-678G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.2 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625603 c.-693G>A upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ala missense_variant 0.22 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625633 p.Asp327Glu missense_variant 0.23 bedaquiline
rifampicin
mtrB 3625637 p.Ala326Asp missense_variant 0.26 bedaquiline
rifampicin
mtrB 3625640 p.Ser325Val missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625654 c.958_960delTTGinsCC frameshift_variant&missense_variant 0.33 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625663 c.-753G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625741 c.-831G>A upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625753 p.Ala287Glu missense_variant 0.4 bedaquiline
rifampicin
lpqB 3625762 c.-852A>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625846 c.-936G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625849 c.763_765delCATinsTC frameshift_variant&missense_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625852 c.-942A>T upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625874 p.Ile247Thr missense_variant 0.22 bedaquiline
rifampicin
mtrA 3626712 p.Thr213His missense_variant 0.19 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626735 c.-122C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 0.29 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626756 c.594C>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626776 c.-163A>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626810 c.-197A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626816 c.-203G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626825 c.-212T>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626828 c.-215T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626831 c.-218T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626840 c.-227C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626888 c.460_462delTTGinsCC frameshift_variant&missense_variant 0.28 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626906 c.442_444delAACinsCG frameshift_variant&missense_variant 0.25 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626915 c.-302C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626924 c.-311G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626942 c.406_408delGTAinsAC frameshift_variant&missense_variant 0.25 bedaquiline
rifampicin
mtrA 3626949 p.Ala134Gly missense_variant 0.26 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626962 p.Met130Leu missense_variant 0.27 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627017 c.-404G>A upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627035 c.-422G>A upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3627038 c.310_312delATGinsGC frameshift_variant&missense_variant 0.54 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3627068 c.282T>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627080 c.270T>C synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrA 3627093 p.Thr86Ser missense_variant 0.53 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627132 p.Ala73Gly missense_variant 0.42 bedaquiline
rifampicin
mtrB 3627134 c.-521C>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627149 c.-536G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627175 c.175C>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627187 c.163T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.28 bedaquiline
rifampicin
mtrB 3627200 c.-587C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627208 c.142C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627227 c.-614T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627247 p.Ile35Val missense_variant 0.21 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
fbiB 3641590 p.Gly19Glu missense_variant 1.0 clofazimine
pretomanid
delamanid Uncertain significance
rpoA 3877504 p.Ala335Gly missense_variant 0.19 rifampicin
rpoA 3877514 p.Thr332Ala missense_variant 0.19 rifampicin Uncertain significance
rpoA 3877515 p.Ser331Asn missense_variant 0.19 rifampicin
rpoA 3877528 p.Thr327Ser missense_variant 0.22 rifampicin
rpoA 3877545 c.963G>C synonymous_variant 0.27 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.35 rifampicin
rpoA 3877587 c.919_921delTCAinsGC frameshift_variant&missense_variant 0.42 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.49 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.48 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.54 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.53 rifampicin
rpoA 3877710 c.798C>G synonymous_variant 0.53 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.46 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.47 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.44 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877827 c.681C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877833 c.675C>G synonymous_variant 0.41 rifampicin
rpoA 3877836 c.672A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>C synonymous_variant 0.42 rifampicin
rpoA 3877848 c.660C>G synonymous_variant 0.41 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.37 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.35 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.31 rifampicin
rpoA 3877896 c.610_612delCCGinsGC frameshift_variant&missense_variant 0.28 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.29 rifampicin
rpoA 3877904 p.Ile202Leu missense_variant 0.28 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.27 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.33 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.38 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.36 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.29 rifampicin
rpoA 3878013 c.495T>C synonymous_variant 0.29 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.28 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.27 rifampicin
rpoA 3878025 c.483C>G synonymous_variant 0.29 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.29 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.29 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.29 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.27 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.28 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.3 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.33 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.31 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.32 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.37 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.36 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.35 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.36 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.37 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.41 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.42 rifampicin
rpoA 3878159 p.Thr117Ala missense_variant 0.46 rifampicin
rpoA 3878163 c.345C>G synonymous_variant 0.47 rifampicin
rpoA 3878185 p.Gly108Ala missense_variant 0.46 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>A synonymous_variant 0.45 rifampicin
rpoA 3878205 c.303T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.46 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.47 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.46 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.43 rifampicin
rpoA 3878270 p.Leu80Ile missense_variant 0.38 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.37 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.34 rifampicin
rpoA 3878304 c.204G>C synonymous_variant 0.31 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>G synonymous_variant 0.26 rifampicin
rpoA 3878337 c.171T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.29 rifampicin
rpoA 3878358 c.150C>A synonymous_variant 0.23 rifampicin
rpoA 3878361 c.147G>C synonymous_variant 0.23 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.23 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.23 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.23 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.23 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878409 c.99C>G synonymous_variant 0.17 rifampicin
rpoA 3878421 c.87A>C synonymous_variant 0.22 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.22 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.2 rifampicin
rpoA 3878442 c.64_66delGTGinsAC frameshift_variant&missense_variant 0.2 rifampicin
rpoA 3878823 c.-316G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.32 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878886 c.-379G>A upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878887 c.-382_-380delAACinsGT upstream_gene_variant 0.29 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.29 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878899 c.-392C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.35 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.34 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.33 rifampicin
rpoA 3878953 c.-446C>G upstream_gene_variant 0.37 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878959 c.-452G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878968 c.-461T>G upstream_gene_variant 0.37 rifampicin
rpoA 3878976 c.-469A>G upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878995 c.-488A>G upstream_gene_variant 0.36 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3879016 c.-509A>C upstream_gene_variant 0.33 rifampicin
rpoA 3879019 c.-512T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.33 rifampicin
rpoA 3879029 c.-522delGinsCGCCGC upstream_gene_variant 0.32 rifampicin
rpoA 3879035 c.-528A>C upstream_gene_variant 0.33 rifampicin
rpoA 3879038 c.-536_-532delCGTGC upstream_gene_variant 0.31 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.33 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.35 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.37 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.33 rifampicin
rpoA 3879125 c.-618T>G upstream_gene_variant 0.34 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879144 c.-637A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.25 rifampicin
rpoA 3879151 c.-644C>G upstream_gene_variant 0.25 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.25 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.32 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.31 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.23 delamanid
pretomanid
clpC1 4038395 c.2310C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>G synonymous_variant 0.2 pyrazinamide
clpC1 4038440 c.2259_2264delTGCGGC disruptive_inframe_deletion 0.2 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.19 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.18 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.23 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.35 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.39 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.39 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.41 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.42 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.45 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.44 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.51 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038698 c.2007C>G synonymous_variant 0.55 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.56 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038794 c.1909_1911delAGCinsTCG synonymous_variant 0.53 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.53 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.54 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.58 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.55 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.57 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.57 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.56 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039031 c.1674T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039037 c.1668T>G synonymous_variant 0.61 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039064 c.1641C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.51 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039139 p.Glu522Asp missense_variant 0.53 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.51 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.37 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039319 c.1384_1386delGCTinsAC frameshift_variant&missense_variant 0.33 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.33 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.34 pyrazinamide
clpC1 4039347 p.Arg453Gln missense_variant 0.38 pyrazinamide Uncertain significance
clpC1 4039382 c.1323C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.42 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.41 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039439 c.1266C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039451 c.1254G>A synonymous_variant 0.36 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039508 c.1197G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.37 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.36 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.47 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039670 c.1035G>T synonymous_variant 0.49 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.6 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.45 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.42 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.43 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040249 c.456A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.28 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>A synonymous_variant 0.25 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.28 pyrazinamide
clpC1 4040315 c.390G>A synonymous_variant 0.28 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040321 c.384C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040342 c.363C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040351 c.354C>T synonymous_variant 0.27 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040363 c.342A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040369 c.334_336delCTCinsTG frameshift_variant&synonymous_variant 0.25 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040414 c.291G>A synonymous_variant 0.32 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040432 c.271_273delAGCinsTCG synonymous_variant 0.31 pyrazinamide
clpC1 4040438 c.267G>A synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040441 c.264C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040483 c.222G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.24 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040576 c.129C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.18 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.18 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138696 p.Pro354Ala missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138702 p.Gln352Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138748 c.1008G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4244889 p.Ile553Leu missense_variant 0.27 ethambutol Uncertain significance
embA 4244897 c.1665T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embA 4244900 c.1668G>C synonymous_variant 0.28 ethambutol
embA 4244904 p.Val558Ile missense_variant 0.29 ethambutol
embA 4244909 c.1677C>G synonymous_variant 0.31 ethambutol
embA 4244910 c.1678C>T synonymous_variant 0.31 ethambutol
embA 4244921 c.1689C>G synonymous_variant 0.32 ethambutol
embA 4244924 c.1692G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embA 4244930 c.1698G>C synonymous_variant 0.31 ethambutol
embA 4244933 c.1701A>C synonymous_variant 0.31 ethambutol
embA 4244945 c.1713C>G synonymous_variant 0.27 ethambutol
embA 4244957 c.1725C>T synonymous_variant 0.23 ethambutol
embA 4244959 p.Ala576Gly missense_variant 0.23 ethambutol
embA 4244978 c.1746G>C synonymous_variant 0.22 ethambutol
embA 4244980 p.Val583Ala missense_variant 0.2 ethambutol
embA 4244987 c.1755T>C synonymous_variant 0.2 ethambutol
embA 4245027 p.Ser599Cys missense_variant 0.18 ethambutol
embA 4245032 c.1800A>T synonymous_variant 0.17 ethambutol
embA 4245050 c.1818C>T synonymous_variant 0.16 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.2 ethambutol
embA 4245074 c.1842G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4245083 c.1851A>C synonymous_variant 0.19 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.19 ethambutol
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248277 c.1764G>C synonymous_variant 0.23 ethambutol
embB 4248286 c.1773G>A synonymous_variant 0.23 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.23 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.24 ethambutol
embB 4248322 c.1809G>T synonymous_variant 0.22 ethambutol
embB 4248329 p.Met606Val missense_variant 0.21 ethambutol
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.91 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R