TB-Profiler result

Run: ERR4797474

Summary

Run ID: ERR4797474

Sample name:

Date: 2024-04-14T00:00:02.010237

Number of reads: 656720

Percentage reads mapped: 12.55

Median coverage: 1.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.95
lineage1.1.1 Indo-Oceanic RD239 0.06
lineage4.9 Euro-American (H37Rv-like) None 0.91
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.766_768delGCTinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.838_840delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.96 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491548 c.766_768delGCTinsCC frameshift_variant&missense_variant 0.43 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491620 c.838_840delATCinsGG frameshift_variant&missense_variant 0.94 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1220 p.Asn407Thr missense_variant 1.0 isoniazid
gyrB 6808 c.1569C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 1.0 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6872 c.1633_1635delTTGinsCC frameshift_variant&missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642_1644delTTGinsCC frameshift_variant&missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin
gyrB 6896 p.Arg553Lys missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6926 c.1687T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6931 c.-371A>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7126 c.-176G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 7156 c.1917C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7159 c.1920C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7162 c.1923C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7391 c.90C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.99 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.98 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7601 c.300C>T synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7667 c.366C>T synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCT frameshift_variant&missense_variant 0.89 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 7709 c.408G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.97 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7796 c.495G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7886 c.585T>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8191 p.Ala297Gly missense_variant 0.89 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8198 c.897T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.89 levofloxacin
moxifloxacin
gyrA 8240 c.939C>A synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8243 c.942C>T synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.89 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.93 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8442 c.1141C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8510 c.1209G>A synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8513 c.1212C>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.96 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.96 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8998 p.Leu566Trp missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9324 c.2023_2025delTCGinsAGC synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCC frameshift_variant&missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9407 c.2106C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490998 c.216T>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491010 c.228C>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491016 c.234C>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fgd1 491022 c.240C>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491031 c.249C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491034 c.252C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491037 c.255C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491055 c.273C>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491067 c.285C>T synonymous_variant 0.88 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491073 c.291C>T synonymous_variant 0.85 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491077 p.Asn99Asp missense_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491085 c.303T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Ile missense_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491142 c.360C>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491481 c.699C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491490 c.708C>T synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fgd1 491500 p.Glu240Lys missense_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fgd1 491523 c.741G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491536 c.754C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>G synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fgd1 491562 c.780C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fgd1 491571 c.789C>T synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fgd1 491574 c.792C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>T synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fgd1 491605 c.823C>T synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fgd1 491655 c.873C>T synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491667 c.885A>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491685 c.903G>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491688 c.906A>G synonymous_variant 0.85 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491697 c.915G>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
mshA 575689 c.342G>C synonymous_variant 0.88 ethionamide
isoniazid
mshA 575692 c.345G>A synonymous_variant 0.87 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.9 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.9 ethionamide
isoniazid
mshA 575725 c.378C>G synonymous_variant 0.94 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.96 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.96 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>A synonymous_variant 0.96 ethionamide
isoniazid
mshA 575761 c.414C>G synonymous_variant 0.98 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.98 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.98 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.98 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.98 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.98 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 1.0 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 1.0 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>T synonymous_variant 1.0 ethionamide
isoniazid
mshA 575837 c.490C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575842 c.495G>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 1.0 ethionamide
isoniazid
ccsA 620337 c.447C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620358 c.468C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620362 c.472_474delGCCinsTG frameshift_variant&missense_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 1.0 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620427 c.537C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620442 c.552G>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620454 c.564C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620463 c.573C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620715 c.825C>T synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620736 c.846G>C synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>C synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620764 c.874_876delGCCinsTG frameshift_variant&missense_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.94 capreomycin
amikacin
kanamycin
ccsA 620781 c.891C>T synonymous_variant 0.92 capreomycin
amikacin
kanamycin
ccsA 620783 p.Ala298Val missense_variant 0.92 capreomycin
amikacin
kanamycin
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.9 ethionamide
Rv0565c 657670 c.-200A>G upstream_gene_variant 0.9 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.9 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 1.0 ethionamide
Rv0565c 657703 c.-233C>A upstream_gene_variant 1.0 ethionamide
Rv0565c 657722 c.-254_-252delAACinsCG upstream_gene_variant 1.0 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 1.0 ethionamide
nusG 734421 c.168A>C synonymous_variant 1.0 rifampicin
nusG 734424 c.171G>C synonymous_variant 1.0 rifampicin
nusG 734439 c.186C>G synonymous_variant 1.0 rifampicin
nusG 734451 c.198G>C synonymous_variant 1.0 rifampicin
nusG 734454 c.201A>G synonymous_variant 1.0 rifampicin
nusG 734460 c.207G>C synonymous_variant 1.0 rifampicin
nusG 734472 c.219T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 1.0 rifampicin
nusG 734532 c.279A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734544 c.291C>T synonymous_variant 1.0 rifampicin
nusG 734559 c.306T>C synonymous_variant 1.0 rifampicin
nusG 734571 c.318C>G synonymous_variant 1.0 rifampicin
nusG 734580 c.327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760082 c.276C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760088 c.282C>G synonymous_variant 1.0 rifampicin
rpoB 760091 c.285G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760104 c.298_300delTCGinsAGC synonymous_variant 1.0 rifampicin
rpoB 760112 c.306T>C synonymous_variant 1.0 rifampicin
rpoB 760118 c.312T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760136 c.330G>A synonymous_variant 1.0 rifampicin
rpoB 760139 c.333A>T synonymous_variant 1.0 rifampicin
rpoB 760142 c.336C>G synonymous_variant 1.0 rifampicin
rpoB 760181 c.375T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 1.0 rifampicin
rpoB 760316 c.510C>G synonymous_variant 1.0 rifampicin
rpoB 760325 c.519G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 1.0 rifampicin
rpoB 760334 c.528G>T synonymous_variant 1.0 rifampicin
rpoB 760340 c.534G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 1.0 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 1.0 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 1.0 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760433 c.627C>T synonymous_variant 1.0 rifampicin
rpoB 760457 c.651C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 1.0 rifampicin
rpoB 760484 c.678A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 1.0 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 1.0 rifampicin
rpoB 760541 c.735G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 1.0 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 1.0 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 1.0 rifampicin
rpoB 760571 c.765G>C synonymous_variant 1.0 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 1.0 rifampicin
rpoB 760591 p.Val262Ala missense_variant 1.0 rifampicin
rpoB 760595 c.789C>T synonymous_variant 1.0 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 1.0 rifampicin
rpoB 760611 c.805T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 1.0 rifampicin
rpoB 760674 c.868T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 1.0 rifampicin
rpoB 760724 c.918T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 1.0 rifampicin
rpoB 760751 c.945G>C synonymous_variant 1.0 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.97 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.97 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.97 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.97 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.97 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.97 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.96 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.96 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.94 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>T synonymous_variant 0.93 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.93 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.93 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.93 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.97 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.97 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.97 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.97 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 1.0 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 1.0 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 1.0 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 1.0 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 1.0 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 1.0 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 1.0 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 1.0 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 1.0 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 1.0 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 1.0 rifampicin
rpoB 761374 p.Val523Asp missense_variant 1.0 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761552 c.1746G>C synonymous_variant 1.0 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 1.0 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 1.0 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 1.0 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 1.0 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 1.0 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 1.0 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 1.0 rifampicin
rpoB 761708 c.1902C>T synonymous_variant 1.0 rifampicin
rpoB 761712 p.Val636Ile missense_variant 1.0 rifampicin
rpoB 761718 c.1912_1913delGCinsT frameshift_variant&missense_variant 1.0 rifampicin
rpoB 761722 p.Glu639Gly missense_variant 0.85 rifampicin Uncertain significance
rpoB 761727 p.Ser641Gly missense_variant 1.0 rifampicin
rpoB 761732 c.1926_1927delCGinsGCA frameshift_variant&missense_variant 1.0 rifampicin
rpoB 761736 p.Ile644Val missense_variant 1.0 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 1.0 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 1.0 rifampicin
rpoB 761772 p.His656Ala missense_variant 1.0 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 1.0 rifampicin
rpoB 761785 p.Thr660Ser missense_variant 1.0 rifampicin
rpoB 761791 p.Arg662His missense_variant 1.0 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 1.0 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 1.0 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 1.0 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 1.0 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>G synonymous_variant 1.0 rifampicin
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 1.0 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 1.0 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 1.0 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 1.0 rifampicin
rpoB 761892 p.Ile696Val missense_variant 1.0 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 1.0 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 1.0 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 1.0 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 1.0 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 1.0 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 1.0 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 1.0 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 1.0 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.99 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.99 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.99 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.99 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762224 c.2418C>G synonymous_variant 0.99 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.97 rifampicin
rpoB 762287 c.2481C>T synonymous_variant 0.97 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.97 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.95 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.97 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.97 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.97 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.97 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.97 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.97 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.97 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.97 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.97 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.97 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.99 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.99 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762515 c.2709C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762527 c.-843G>C upstream_gene_variant 1.0 rifampicin
rpoC 762533 c.-837T>A upstream_gene_variant 1.0 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 1.0 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 1.0 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.96 rifampicin
rpoB 762833 c.3027C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 1.0 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763022 c.-348C>G upstream_gene_variant 0.97 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.95 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.94 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.95 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 1.0 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 1.0 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 1.0 rifampicin
rpoC 763199 c.-171G>C upstream_gene_variant 1.0 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 1.0 rifampicin
rpoC 763205 c.-165G>T upstream_gene_variant 1.0 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 1.0 rifampicin
rpoC 763217 c.-153G>C upstream_gene_variant 1.0 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 1.0 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 1.0 rifampicin
rpoC 763232 c.-138C>T upstream_gene_variant 1.0 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 1.0 rifampicin
rpoB 763241 p.Glu1145Asp missense_variant 1.0 rifampicin
rpoC 763375 c.6C>A synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.83 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.83 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.83 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.83 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.83 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.91 rifampicin
rpoC 763456 c.87A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 1.0 rifampicin
rpoC 763528 c.159G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.98 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.96 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.96 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.96 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.97 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.98 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.98 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.98 rifampicin
rpoC 763807 c.438T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 1.0 rifampicin
rpoC 763831 c.462A>G synonymous_variant 1.0 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.97 rifampicin
rpoC 763840 c.471G>C synonymous_variant 1.0 rifampicin
rpoC 763858 c.489A>G synonymous_variant 1.0 rifampicin
rpoC 763861 c.492C>T synonymous_variant 1.0 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 1.0 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 1.0 rifampicin
rpoC 763879 c.510A>G synonymous_variant 1.0 rifampicin
rpoC 763882 c.513G>A synonymous_variant 1.0 rifampicin
rpoC 763891 c.522G>C synonymous_variant 1.0 rifampicin
rpoC 763894 c.525A>G synonymous_variant 1.0 rifampicin
rpoC 763900 c.531G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 1.0 rifampicin
rpoC 763924 c.555G>A synonymous_variant 1.0 rifampicin
rpoC 763930 c.561G>A synonymous_variant 1.0 rifampicin
rpoC 763933 c.564C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 1.0 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.97 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.97 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 1.0 rifampicin
rpoC 763987 c.618C>T synonymous_variant 1.0 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 1.0 rifampicin
rpoC 763996 c.627T>C synonymous_variant 1.0 rifampicin
rpoC 764131 c.762T>C synonymous_variant 1.0 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764153 p.Gln262Lys missense_variant 0.97 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.97 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.97 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764195 c.826_828delTCGinsAGC synonymous_variant 0.94 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.94 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.94 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.94 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.95 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.95 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.96 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.96 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.96 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.96 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.96 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.98 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.98 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 1.0 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 1.0 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 1.0 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 1.0 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 1.0 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 1.0 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 1.0 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 1.0 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 1.0 rifampicin
rpoC 764912 p.Met515Gln missense_variant 1.0 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 1.0 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 1.0 rifampicin
rpoC 765016 c.1647C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765022 c.1653G>T synonymous_variant 1.0 rifampicin
rpoC 765034 c.1665T>C synonymous_variant 1.0 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 1.0 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 1.0 rifampicin
rpoC 765083 p.Arg572Lys missense_variant 1.0 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 1.0 rifampicin
rpoC 765121 c.1752G>T synonymous_variant 1.0 rifampicin
rpoC 765383 p.Met672Leu missense_variant 1.0 rifampicin Uncertain significance
rpoC 765400 c.2031G>C synonymous_variant 1.0 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 1.0 rifampicin
rpoC 765404 p.Leu679Lys missense_variant 1.0 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 1.0 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 1.0 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 1.0 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 1.0 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 1.0 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.96 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.95 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.94 rifampicin Uncertain significance
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.8 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.75 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.75 rifampicin
rpoC 765577 c.2208G>T synonymous_variant 0.73 rifampicin
rpoC 765718 p.Asp783Glu missense_variant 0.9 rifampicin Uncertain significance
rpoC 765724 c.2355C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Lys missense_variant 0.9 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765737 p.Arg790Glu missense_variant 0.9 rifampicin
rpoC 765743 p.His792Tyr missense_variant 0.93 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.94 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.94 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.96 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.96 rifampicin
rpoC 765779 c.2410_2412delGACinsAG frameshift_variant&missense_variant 0.96 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.97 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.97 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.97 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.97 rifampicin
rpoC 765814 c.2445A>C synonymous_variant 0.97 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.97 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.98 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.98 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.96 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.98 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.96 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.96 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.96 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.96 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.96 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.92 rifampicin
rpoC 766027 c.2658G>T synonymous_variant 0.9 rifampicin
rpoC 766034 p.His889Thr missense_variant 0.89 rifampicin
rpoC 766042 c.2673C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Glu missense_variant 0.88 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 1.0 rifampicin
rpoC 766658 c.3289_3291delCGGinsGC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 1.0 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 1.0 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 1.0 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 1.0 rifampicin
rpoC 766694 c.3325_3327delCAGinsGC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 1.0 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 1.0 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 1.0 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 1.0 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 1.0 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 1.0 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 1.0 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 1.0 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 1.0 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>T synonymous_variant 1.0 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 1.0 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.98 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.92 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.92 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.92 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.92 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
mmpL5 775851 p.Ser877Thr missense_variant 0.93 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775877 c.2604C>G synonymous_variant 0.81 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsTG frameshift_variant&missense_variant 0.8 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775892 c.2589C>T synonymous_variant 0.83 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.96 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.96 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 775921 c.2560C>T synonymous_variant 0.9 clofazimine
bedaquiline
mmpL5 775924 c.2557C>T synonymous_variant 0.91 clofazimine Not assoc w R - Interim
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.97 clofazimine
bedaquiline
mmpL5 775955 c.2524_2526delATCinsGG frameshift_variant&missense_variant 0.6 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775964 c.2515_2517delGCGinsTC frameshift_variant&missense_variant 0.56 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775970 c.2511G>C synonymous_variant 0.39 clofazimine
bedaquiline
mmpL5 775973 c.2506_2508delTTGinsAC frameshift_variant&missense_variant 0.55 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775981 p.Leu834Met missense_variant 1.0 clofazimine
bedaquiline
mmpL5 775994 c.2485_2487delATCinsCG frameshift_variant&missense_variant 0.97 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775997 c.2484T>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776003 c.2476_2478delATCinsCG frameshift_variant&missense_variant 0.47 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776009 c.2472A>G synonymous_variant 0.57 clofazimine
bedaquiline
mmpL5 776024 c.2457G>C synonymous_variant 0.43 clofazimine
bedaquiline
mmpL5 776030 c.2451G>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776047 c.2434C>T synonymous_variant 0.43 clofazimine
bedaquiline
mmpL5 776053 c.2428T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776066 c.2415C>G synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.9 clofazimine
bedaquiline
mmpL5 776081 c.2400G>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776084 c.2397C>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776087 c.2394C>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Leu missense_variant 1.0 clofazimine
bedaquiline
mmpL5 776132 c.2347_2349delGCAinsTG frameshift_variant&missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776135 c.2344_2346delTCCinsGG frameshift_variant&missense_variant 0.9 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpsL 781572 c.13_15delCAGinsAC frameshift_variant&missense_variant 1.0 streptomycin Uncertain significance
rpsL 781595 c.36T>C synonymous_variant 0.94 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.94 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.94 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.94 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.95 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.96 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.97 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.97 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.98 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.98 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.97 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.97 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.96 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.96 streptomycin Uncertain significance
rpsL 781739 c.180_181insCGGC frameshift_variant 0.96 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 0.96 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.96 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.97 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.97 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.96 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.96 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.95 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.96 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.98 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.98 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.98 streptomycin
rpsL 781859 c.300T>G synonymous_variant 1.0 streptomycin
rpsL 781865 c.306G>C synonymous_variant 1.0 streptomycin
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin
rpsL 781892 c.333A>G synonymous_variant 1.0 streptomycin
rpsL 781898 c.339A>C synonymous_variant 1.0 streptomycin
rpsL 781901 c.342C>T synonymous_variant 1.0 streptomycin
rpsL 781907 c.348T>C synonymous_variant 1.0 streptomycin
rpsL 781916 c.357T>C synonymous_variant 1.0 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 1.0 linezolid
rplC 800543 c.-266C>T upstream_gene_variant 1.0 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 1.0 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 1.0 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 1.0 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 1.0 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 1.0 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 1.0 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 1.0 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 1.0 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 1.0 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 1.0 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 1.0 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 1.0 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 1.0 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 1.0 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 1.0 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 1.0 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 1.0 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 1.0 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 1.0 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 1.0 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 1.0 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 1.0 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 1.0 linezolid
rplC 800904 c.96G>C synonymous_variant 1.0 linezolid
rplC 800916 c.108A>G synonymous_variant 1.0 linezolid
rplC 800921 p.Arg38Leu missense_variant 1.0 linezolid
rplC 800928 c.120C>T synonymous_variant 1.0 linezolid
rplC 800931 c.123G>C synonymous_variant 1.0 linezolid
rplC 800937 c.129A>G synonymous_variant 1.0 linezolid
rplC 800946 c.138T>C synonymous_variant 1.0 linezolid
rplC 800949 c.141T>C synonymous_variant 1.0 linezolid
rplC 800964 c.156G>C synonymous_variant 1.0 linezolid
rplC 800985 c.177A>G synonymous_variant 1.0 linezolid
rplC 801237 c.429G>A synonymous_variant 1.0 linezolid
rplC 801252 c.444G>C synonymous_variant 1.0 linezolid
rplC 801264 c.456C>T synonymous_variant 1.0 linezolid
rplC 801267 c.459A>C synonymous_variant 1.0 linezolid
rplC 801276 c.468G>C synonymous_variant 1.0 linezolid
rplC 801281 p.Ala158Gly missense_variant 1.0 linezolid
rplC 801285 c.477G>C synonymous_variant 1.0 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 1.0 linezolid
rplC 801312 c.504G>C synonymous_variant 1.0 linezolid
rplC 801315 c.507G>T synonymous_variant 1.0 linezolid
rplC 801324 c.516T>C synonymous_variant 1.0 linezolid
fbiC 1303509 c.579G>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303536 c.606G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303548 c.618G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303587 c.657G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303593 c.663G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303629 c.699C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303644 c.714G>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304505 c.1575G>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304515 p.Ala529Thr missense_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304541 c.1611C>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.96 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.93 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304751 c.1821C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
sigE 1364640 c.228G>C synonymous_variant 1.0 pyrazinamide
sigE 1364643 c.231C>T synonymous_variant 1.0 pyrazinamide
sigE 1364644 p.Lys78Gln missense_variant 1.0 pyrazinamide
sigE 1364650 p.Thr80Ala missense_variant 1.0 pyrazinamide Uncertain significance
sigE 1364661 c.249C>G synonymous_variant 1.0 pyrazinamide
sigE 1364679 c.267T>C synonymous_variant 0.95 pyrazinamide
sigE 1364682 c.270G>A synonymous_variant 0.95 pyrazinamide
sigE 1364688 c.276C>T synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
sigE 1364691 c.279T>C synonymous_variant 0.97 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.97 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.97 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.97 pyrazinamide
sigE 1364724 c.312C>T synonymous_variant 0.97 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.97 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.97 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.97 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.97 pyrazinamide
sigE 1364781 c.369G>C synonymous_variant 0.96 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.96 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.97 pyrazinamide
sigE 1364796 c.384G>A synonymous_variant 0.96 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.96 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.96 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.96 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 1.0 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 1.0 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 1.0 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 1.0 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 1.0 pyrazinamide
sigE 1364871 c.459C>T synonymous_variant 1.0 pyrazinamide
sigE 1364877 c.465G>T synonymous_variant 1.0 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 1.0 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.95 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.95 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.9 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.9 pyrazinamide
sigE 1364931 c.519C>T synonymous_variant 0.93 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.93 pyrazinamide Uncertain significance
sigE 1364956 c.544C>T synonymous_variant 0.93 pyrazinamide
sigE 1364962 c.550_552delCCTinsGC frameshift_variant&missense_variant 0.93 pyrazinamide Uncertain significance
sigE 1364976 c.564T>C synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.91 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.91 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.91 pyrazinamide
sigE 1364989 c.577C>T synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
sigE 1364992 p.Pro194Ala missense_variant 0.91 pyrazinamide
sigE 1365000 c.588G>A synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
sigE 1365006 c.594T>C synonymous_variant 0.92 pyrazinamide
sigE 1365018 c.606G>C synonymous_variant 0.92 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.9 pyrazinamide
sigE 1365048 c.636G>A synonymous_variant 0.94 pyrazinamide
sigE 1365051 c.639G>A synonymous_variant 0.94 pyrazinamide
sigE 1365063 c.651A>G synonymous_variant 0.93 pyrazinamide
sigE 1365069 c.657C>T synonymous_variant 0.93 pyrazinamide
rrs 1471922 n.78delT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.98 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.98 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.98 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.99 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154_155insT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473814 n.158delT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474053 n.396G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474102 n.446_449delAGTA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474110 n.453_454insCGGTG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_632delCCinsTCGACT non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474419 n.762_773delACGCGCATACGCinsGCAGTA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474432 n.775C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474438 n.781_782delAAinsGTG non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAGT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475382 n.1725A>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475395 n.1738T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid Uncertain significance
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
inhA 1673607 c.-595T>C upstream_gene_variant 0.85 ethionamide
isoniazid
fabG1 1673615 p.Glu59Val missense_variant 0.85 ethionamide
isoniazid
inhA 1673622 c.-580C>T upstream_gene_variant 0.85 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.86 ethionamide
isoniazid
fabG1 1673637 p.Asp66Glu missense_variant 0.86 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.83 ethionamide
isoniazid
inhA 1673649 c.-553C>T upstream_gene_variant 0.83 ethionamide
isoniazid
inhA 1673652 c.-550C>G upstream_gene_variant 0.83 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.83 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.83 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.85 ethionamide
isoniazid
inhA 1673703 c.-499C>T upstream_gene_variant 0.87 ethionamide
isoniazid
fabG1 1673708 c.270_271delCC frameshift_variant 0.83 ethionamide
isoniazid
fabG1 1673714 c.275_276insT frameshift_variant 0.83 ethionamide
isoniazid
fabG1 1673717 c.278_279insA frameshift_variant 0.83 ethionamide
isoniazid
inhA 1673724 c.-478A>G upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673730 c.-472C>G upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 1.0 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 1.0 ethionamide
isoniazid
inhA 1673913 c.-289C>G upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 1.0 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 1.0 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673931 c.-271C>G upstream_gene_variant 1.0 ethionamide
isoniazid
fabG1 1673941 c.502_504delGCCinsTG frameshift_variant&missense_variant 1.0 ethionamide
isoniazid
inhA 1673952 c.-250G>T upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 1.0 ethionamide
isoniazid
fabG1 1673962 p.Asn175Gly missense_variant 1.0 ethionamide
isoniazid
inhA 1673967 c.-235G>C upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673973 c.-229G>C upstream_gene_variant 1.0 ethionamide
isoniazid Uncertain significance
inhA 1673976 c.-226T>C upstream_gene_variant 1.0 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 1.0 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.82 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 1.0 ethionamide
isoniazid
inhA 1674672 c.471C>A synonymous_variant 1.0 ethionamide
isoniazid
rpsA 1833589 c.48A>C synonymous_variant 1.0 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 1.0 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 1.0 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 1.0 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 1.0 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 1.0 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 1.0 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 1.0 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 1.0 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.97 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 1.0 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.97 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.97 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.97 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.97 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.98 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.98 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.98 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.95 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.93 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.95 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.95 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.98 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.98 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.98 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.98 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.97 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.97 pyrazinamide
rpsA 1834078 c.537C>T synonymous_variant 0.96 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 1.0 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.97 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.96 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.95 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.95 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.96 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.94 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.96 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.96 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.96 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.96 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.96 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.96 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.98 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.98 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.98 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 1.0 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 1.0 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 1.0 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 1.0 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 1.0 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 1.0 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834829 c.1288_1290delGCGinsAC frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1853361 c.-245T>C upstream_gene_variant 1.0 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 1.0 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 1.0 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 1.0 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 1.0 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 1.0 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 1.0 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 1.0 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 1.0 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 1.0 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 1.0 linezolid
katG 2155691 c.421T>C synonymous_variant 0.91 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.92 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.92 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.92 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.92 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.96 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.94 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.94 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.93 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.92 isoniazid
kasA 2517980 c.-135C>T upstream_gene_variant 0.95 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.88 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.93 isoniazid
kasA 2518697 p.Cys195Val missense_variant 1.0 isoniazid
kasA 2518708 c.594C>G synonymous_variant 1.0 isoniazid
kasA 2518714 c.600A>C synonymous_variant 1.0 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 1.0 isoniazid
kasA 2518726 c.612G>A synonymous_variant 1.0 isoniazid
kasA 2518732 c.618C>G synonymous_variant 1.0 isoniazid
kasA 2518747 c.633C>G synonymous_variant 1.0 isoniazid
kasA 2518756 c.642G>C synonymous_variant 1.0 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 1.0 isoniazid
kasA 2518783 c.669T>C synonymous_variant 1.0 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.97 isoniazid
kasA 2518787 c.673_675delCGGinsGT frameshift_variant&missense_variant 0.97 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.97 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.97 isoniazid
kasA 2518813 c.699C>T synonymous_variant 0.97 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.97 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.97 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.94 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.94 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.91 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.93 isoniazid
kasA 2518877 p.Lys255Leu missense_variant 0.91 isoniazid
Rv2477c 2783344 c.699C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 p.Pro206Lys missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.95 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783456 p.Gln196Leu missense_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2996440 c.-299G>C upstream_gene_variant 0.92 capreomycin
Rv2681 2996443 c.-296T>C upstream_gene_variant 0.92 capreomycin
Rv2680 2996446 c.342A>G synonymous_variant 0.92 capreomycin Not assoc w R - Interim
Rv2681 2996449 c.-290C>T upstream_gene_variant 0.92 capreomycin
Rv2681 2996458 c.-281C>A upstream_gene_variant 0.92 capreomycin
Rv2681 2996461 c.-278G>C upstream_gene_variant 0.92 capreomycin
Rv2681 2996470 c.-269G>A upstream_gene_variant 0.92 capreomycin
Rv2681 2996476 c.-263A>C upstream_gene_variant 0.92 capreomycin
Rv2681 2996482 c.-257T>C upstream_gene_variant 0.9 capreomycin
Rv2752c 3065022 c.1170G>C synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065058 c.1134C>G synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065061 c.1131C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065064 c.1128G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065070 c.1122C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065079 c.1113T>C synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065082 c.1110G>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065126 p.Ser356Ala missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065130 c.1062A>G synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065133 c.1059T>C synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065142 c.1050A>G synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065146 p.Phe349Tyr missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065154 c.1038G>A synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065160 c.1032C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065166 c.1026C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065174 c.1018C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
thyX 3067808 c.138C>T synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067817 c.129C>T synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067820 c.126C>G synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067825 c.121C>A synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067839 p.Val36Thr missense_variant 0.93 para-aminosalicylic_acid
thyX 3067841 c.105G>C synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067847 c.99C>T synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067853 c.93C>T synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067862 c.84C>T synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.93 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067883 c.63C>T synonymous_variant 0.93 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.93 para-aminosalicylic_acid
lpqB 3624675 p.Asn79Ser missense_variant 0.91 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.91 bedaquiline
rifampicin
lpqB 3624701 c.210T>G synonymous_variant 0.92 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.92 bedaquiline
rifampicin
lpqB 3624719 c.192C>T synonymous_variant 0.92 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625135 c.-225A>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 1.0 bedaquiline
rifampicin
lpqB 3625156 c.-246G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625168 c.-258G>T upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625174 c.-264C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625186 c.-276T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625204 c.-294G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625207 c.-297C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>G upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3625252 c.1362G>C synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625255 c.-345T>C upstream_gene_variant 0.92 bedaquiline
rifampicin
lpqB 3625258 c.-348G>T upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3625264 c.1350C>T synonymous_variant 0.92 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625267 c.1347T>C synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625588 c.-678G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625612 c.-702G>T upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625615 c.-705G>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ala missense_variant 1.0 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625636 p.Ala326Glu missense_variant 1.0 bedaquiline
rifampicin
mtrB 3625645 c.969C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625657 c.-747C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625663 c.-753G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625711 c.903C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.98 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3625753 p.Ala287Gln missense_variant 0.97 bedaquiline
rifampicin
lpqB 3625762 c.-852A>C upstream_gene_variant 0.97 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.97 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625770 c.-860C>T upstream_gene_variant 0.97 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.95 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625822 c.-912C>T upstream_gene_variant 0.93 bedaquiline
rifampicin
lpqB 3625828 c.-918G>C upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3625845 p.Ser257Thr missense_variant 0.9 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3625867 c.747A>G synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626704 c.-91C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626711 p.Thr213Gln missense_variant 1.0 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626753 c.-140G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 1.0 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626792 c.-179G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 1.0 bedaquiline
rifampicin Uncertain significance
mtrB 3626999 c.-386G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627002 c.-389G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627032 c.-419G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 1.0 bedaquiline
rifampicin
mtrB 3627044 c.-431C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627062 c.-449G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627137 c.211_213delTTGinsCC frameshift_variant&missense_variant 1.0 bedaquiline
rifampicin
mtrB 3627158 c.-545C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
rpoA 3877530 c.978C>A synonymous_variant 0.9 rifampicin
rpoA 3877534 p.Val325Ala missense_variant 0.9 rifampicin
rpoA 3877545 c.963G>C synonymous_variant 0.9 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877566 p.Ser314Thr missense_variant 0.82 rifampicin
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.82 rifampicin
rpoA 3877584 c.924C>G synonymous_variant 0.94 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877590 c.918G>C synonymous_variant 0.94 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877602 c.906C>T synonymous_variant 0.94 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.96 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.96 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.95 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.94 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 1.0 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.98 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.98 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.98 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.96 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.97 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.97 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.96 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.98 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 1.0 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 1.0 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 1.0 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 1.0 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 1.0 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 1.0 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 1.0 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 1.0 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 1.0 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 1.0 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 1.0 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 1.0 rifampicin
rpoA 3878061 c.447G>A synonymous_variant 1.0 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 1.0 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 1.0 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 1.0 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 1.0 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 1.0 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 1.0 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 1.0 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 1.0 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 1.0 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 1.0 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 1.0 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 1.0 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 1.0 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 1.0 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>A synonymous_variant 0.93 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.92 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878385 c.123C>G synonymous_variant 0.91 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878442 c.66G>C synonymous_variant 0.83 rifampicin
rpoA 3878450 p.Gln20Lys missense_variant 0.91 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.91 rifampicin
clpC1 4038383 c.2322G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038395 c.2310C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038401 c.2302_2304delTTGinsCC frameshift_variant&missense_variant 1.0 pyrazinamide
clpC1 4038410 c.2295C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 1.0 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038456 p.Val750Gln missense_variant 1.0 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 1.0 pyrazinamide
clpC1 4038462 p.Ala748Glu missense_variant 1.0 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 1.0 pyrazinamide
clpC1 4038479 c.2226C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 1.0 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 1.0 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 1.0 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 1.0 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 1.0 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 1.0 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038584 c.2121G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 1.0 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 1.0 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 1.0 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 1.0 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 1.0 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.94 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.97 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.97 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.97 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.98 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.96 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 1.0 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.98 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.98 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.98 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.98 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.98 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
clpC1 4038997 c.1708T>C synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.97 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.96 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.97 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039103 c.1602T>A synonymous_variant 0.97 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.97 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039145 c.1560G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 1.0 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 1.0 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 1.0 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 1.0 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 1.0 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 1.0 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 1.0 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039487 c.1218G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.97 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.97 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.97 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.97 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.98 pyrazinamide
clpC1 4039616 c.1089G>T synonymous_variant 0.97 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.96 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.99 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.98 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.97 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.94 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.92 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4039766 c.939T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.96 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.92 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.92 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.94 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.94 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.98 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039942 c.763C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.98 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 1.0 pyrazinamide
clpC1 4040081 c.624C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 1.0 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 1.0 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040195 c.510G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 1.0 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 1.0 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>C synonymous_variant 0.93 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4040324 c.381G>C synonymous_variant 0.89 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.88 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.89 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.89 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.86 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.86 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 1.0 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 1.0