TB-Profiler result

Run: ERR161039
Summary

Run ID: ERR161039

Sample name:

Date: 2024-04-15T13:31:41.545276

Number of reads: 1603519

Percentage reads mapped: 45.0

Median coverage: 32.0

Strain: La3;lineage4.3.4

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.1.2 Indo-Oceanic RD239 0.05
lineage4.3 Euro-American (LAM) None 0.96
La3 M.orygis None 0.1
lineage4.3.4 Euro-American (LAM) RD174 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.877_879delCTGinsAA Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.196_198delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.202_204delCTGinsAT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.2491_2493delGCTinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 490978 c.196_198delAACinsGG frameshift_variant&missense_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 490984 c.202_204delCTGinsAT frameshift_variant&missense_variant 0.26 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.41 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305421 c.2491_2493delGCTinsTG frameshift_variant&missense_variant 0.4 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155233 c.877_879delCTGinsAA frameshift_variant&missense_variant 0.29 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 504 c.504T>C synonymous_variant 0.2 isoniazid
dnaA 510 c.510T>G synonymous_variant 0.28 isoniazid
dnaA 522 c.522T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 525 c.525T>C synonymous_variant 0.42 isoniazid
dnaA 534 c.534T>C synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>C synonymous_variant 0.49 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.48 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.48 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 588 c.588A>G synonymous_variant 0.46 isoniazid
dnaA 594 c.594C>T synonymous_variant 0.46 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.42 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.35 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.26 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.34 isoniazid
dnaA 795 c.795A>G synonymous_variant 0.45 isoniazid
dnaA 810 c.810C>G synonymous_variant 0.47 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.52 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.54 isoniazid Not assoc w R - Interim
dnaA 840 c.840G>A synonymous_variant 0.55 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.55 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.56 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.58 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.54 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.54 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.55 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 921 c.921A>G synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 930 c.930G>A synonymous_variant 0.48 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.48 isoniazid
dnaA 954 c.954G>A synonymous_variant 0.42 isoniazid
dnaA 955 c.955_957delAGAinsCG frameshift_variant&synonymous_variant 0.42 isoniazid Uncertain significance
dnaA 963 c.963C>G synonymous_variant 0.45 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.46 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.48 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.33 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.33 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>A synonymous_variant 0.39 isoniazid
gyrB 6100 c.861G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6109 c.870G>A synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6115 c.876A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrB 6124 c.885C>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6140 p.Val301Leu missense_variant 0.48 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6148 c.909C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6169 c.930C>T synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6196 c.957C>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrB 6203 p.Ser322Ala missense_variant 0.58 levofloxacin
moxifloxacin
gyrB 6214 c.975G>A synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6223 c.984G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6250 c.1011A>G synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6307 c.-995T>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6310 c.-992G>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6421 c.-881C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6496 c.-806G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>T upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 6531 p.Ser431Thr missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6556 c.-746C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6652 c.-650C>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6733 c.-569G>A upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.68 levofloxacin
moxifloxacin
gyrA 6808 c.-494C>A upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6872 c.1633_1635delTTGinsCC frameshift_variant&missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6898 c.-404G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6925 c.-377T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.63 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 7156 c.1917C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7178 c.-124T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7189 c.-113C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7216 c.-86G>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7243 c.-59G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7246 c.2007T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7252 c.-50G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7415 c.114C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7475 c.174A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7655 c.354G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7685 c.384G>A synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7688 c.387C>T synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7691 c.390C>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7697 c.396C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 7759 p.Ile153Thr missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7775 c.474C>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7796 c.495G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7847 c.546G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7862 c.561C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8054 c.753T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8071 p.Val257Ala missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8076 p.Val259Ile missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8084 c.783G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8096 c.795T>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8102 c.801C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.51 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.51 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8408 c.1107A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8597 c.1296C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8637 c.1336C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8648 c.1347G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8684 c.1383G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8690 c.1389C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8795 c.1494C>T synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8829 c.1528T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8836 p.Ala512Val missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin
gyrA 8840 c.1539C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8933 c.1632G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8936 c.1635G>A synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.55 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9014 c.1713C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9059 c.1758G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9104 c.1803C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9110 c.1809G>A synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9113 c.1812C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9212 c.1911G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9267 p.Asn656Gly missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9345 c.2044A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9352 p.Ser684Leu missense_variant 0.78 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9419 c.2118T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Ala missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 9429 p.Arg710Tyr missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 9441 c.2140C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9449 c.2148C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9452 c.2151G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9455 c.2154T>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9464 c.2163C>A synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9476 c.2175G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9485 c.2184A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9653 c.2352C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9656 c.2355C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9665 c.2364A>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9668 c.2367C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9674 c.2373T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9683 c.2382G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9695 c.2394C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9716 c.2415T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9717 c.2416C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9740 c.2439G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490875 c.93C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490899 c.117C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Lys missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490971 c.189A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490987 p.Leu69Val missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491016 c.234C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491022 c.240C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491133 c.351A>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491142 c.360C>T synonymous_variant 0.39 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491144 p.Ala121Glu missense_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.6 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491295 c.513C>G synonymous_variant 0.6 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491310 c.528C>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>A synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.6 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491388 c.606C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491484 c.702C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491509 p.Leu243Arg missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491556 c.774G>A synonymous_variant 0.59 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491589 c.807G>A synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491598 c.816C>A synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491670 c.888G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491685 c.903G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491688 c.906A>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491697 c.915G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491703 c.921C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
mshA 574694 c.-654C>G upstream_gene_variant 0.19 ethionamide
isoniazid
mshA 574739 c.-609T>C upstream_gene_variant 0.19 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575665 c.318G>T synonymous_variant 0.36 ethionamide
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.44 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.39 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.51 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.56 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.54 ethionamide
isoniazid
mshA 575740 c.393G>C synonymous_variant 0.54 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.46 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.45 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.48 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.53 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.53 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.54 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.57 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.56 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.61 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.65 ethionamide
isoniazid
ccsA 619624 c.-267C>T upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257_-255delTCCinsGTT upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619648 c.-243C>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619650 c.-241T>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>T upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619655 c.-236A>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>G upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619676 c.-215C>T upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619681 c.-210G>C upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620247 p.Leu119Phe missense_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620269 p.Val127Ile missense_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620275 c.385_387delCTGinsTA frameshift_variant&stop_gained 0.47 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>A synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>T synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsTG frameshift_variant&missense_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620404 c.514C>T synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.47 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620418 c.528G>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>G synonymous_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620457 c.567C>G synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>T synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620647 p.Glu253Gln missense_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>A synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620658 c.768C>T synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620670 c.780C>A synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620692 c.802_804delTCCinsGG frameshift_variant&missense_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620752 p.Arg288Gly missense_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAA frameshift_variant&missense_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620780 p.Val297Ala missense_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>A synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>A synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620808 c.918T>C synonymous_variant 0.37 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620832 c.942C>T synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620835 c.945C>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
Rv0565c 656538 p.Ser311Glu missense_variant 0.4 ethionamide
Rv0565c 656547 c.924C>G synonymous_variant 0.41 ethionamide
Rv0565c 656552 p.Asn307Asp missense_variant 0.41 ethionamide
Rv0565c 656553 c.918C>T synonymous_variant 0.41 ethionamide
Rv0565c 656556 c.915G>C synonymous_variant 0.41 ethionamide Not assoc w R - Interim
Rv0565c 656568 c.903G>C synonymous_variant 0.43 ethionamide
Rv0565c 656582 c.889C>T synonymous_variant 0.43 ethionamide
Rv0565c 656583 c.888A>G synonymous_variant 0.43 ethionamide
Rv0565c 656611 p.Thr287Lys missense_variant 0.25 ethionamide
Rv0565c 656880 c.591C>G synonymous_variant 0.29 ethionamide
Rv0565c 656883 c.588C>T synonymous_variant 0.28 ethionamide Not assoc w R - Interim
Rv0565c 656891 p.Thr194Ser missense_variant 0.27 ethionamide
Rv0565c 656892 c.577_579delGTCinsAT frameshift_variant&missense_variant 0.26 ethionamide Uncertain significance
Rv0565c 656916 c.555G>C synonymous_variant 0.25 ethionamide
Rv0565c 656922 p.Ile183Met missense_variant 0.24 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.28 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.28 ethionamide
Rv0565c 657267 p.Ser68Cys missense_variant 0.28 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.23 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.25 ethionamide
Rv0565c 657581 c.-111G>C upstream_gene_variant 0.29 ethionamide
Rv0565c 657590 c.-120G>C upstream_gene_variant 0.4 ethionamide
Rv0565c 657596 c.-126G>C upstream_gene_variant 0.44 ethionamide
Rv0565c 657617 c.-147G>C upstream_gene_variant 0.53 ethionamide
Rv0565c 657629 c.-159G>A upstream_gene_variant 0.57 ethionamide
Rv0565c 657640 c.-170A>T upstream_gene_variant 0.62 ethionamide
Rv0565c 657644 c.-174G>C upstream_gene_variant 0.59 ethionamide
Rv0565c 657668 c.-198C>G upstream_gene_variant 0.59 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.62 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.56 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.57 ethionamide
Rv0565c 657704 c.-234G>A upstream_gene_variant 0.55 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.48 ethionamide
hadA 731747 c.-183T>C upstream_gene_variant 0.28 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.32 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.53 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.56 isoniazid
hadA 731795 c.-135C>T upstream_gene_variant 0.54 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.54 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.47 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.41 isoniazid
hadA 731861 c.-69G>C upstream_gene_variant 0.37 isoniazid
nusG 734421 c.168A>C synonymous_variant 0.23 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.26 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.39 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.5 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.49 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
nusG 734544 c.291C>T synonymous_variant 0.53 rifampicin
nusG 734547 c.294G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.45 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.43 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.36 rifampicin
nusG 734595 c.342C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734811 c.558G>A synonymous_variant 0.31 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.31 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.37 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.52 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.51 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.51 rifampicin
nusG 734862 c.609C>G synonymous_variant 0.54 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.55 rifampicin
nusG 734889 c.636G>A synonymous_variant 0.57 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.57 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.49 rifampicin
nusG 734934 c.681G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 759606 c.-201T>C upstream_gene_variant 0.23 rifampicin
rpoB 759616 c.-191C>T upstream_gene_variant 0.36 rifampicin
rpoB 759621 c.-186C>T upstream_gene_variant 0.38 rifampicin
rpoB 759643 c.-164T>C upstream_gene_variant 0.34 rifampicin
rpoB 759647 c.-160T>C upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoB 759655 c.-152_-149delCAGTinsG upstream_gene_variant 0.27 rifampicin
rpoB 759671 c.-136G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoB 759672 c.-135G>A upstream_gene_variant 0.29 rifampicin
rpoB 759674 c.-133T>C upstream_gene_variant 0.29 rifampicin
rpoB 759678 c.-129T>C upstream_gene_variant 0.31 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.3 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.48 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.5 rifampicin
rpoB 760118 c.312T>A synonymous_variant 0.52 rifampicin
rpoB 760121 c.315T>G synonymous_variant 0.59 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.61 rifampicin Uncertain significance
rpoB 760139 c.333A>C synonymous_variant 0.61 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.61 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.62 rifampicin
rpoB 760310 c.504G>T synonymous_variant 0.6 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.59 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.57 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.51 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.54 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.6 rifampicin Uncertain significance
rpoB 760388 c.582C>T synonymous_variant 0.52 rifampicin
rpoB 760389 c.583_584delAGinsTC synonymous_variant 0.49 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.51 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>G synonymous_variant 0.52 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.52 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Ser missense_variant 0.48 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.56 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.56 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760643 c.837G>A synonymous_variant 0.56 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.58 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760710 c.904C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760796 c.990A>G synonymous_variant 0.28 rifampicin
rpoB 760802 c.996C>G synonymous_variant 0.33 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.37 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.45 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.46 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.62 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.63 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.63 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.59 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.58 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.6 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.59 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.59 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.59 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.38 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.41 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>C synonymous_variant 0.36 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.37 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.53 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.59 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.64 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.66 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.58 rifampicin
rpoB 761345 c.1539G>T synonymous_variant 0.53 rifampicin
rpoB 761346 p.Val514Arg missense_variant 0.54 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.56 rifampicin
rpoB 761362 p.Ser519Thr missense_variant 0.56 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.54 rifampicin
rpoB 761396 c.1590G>A synonymous_variant 0.52 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.4 rifampicin
rpoB 761411 c.1605G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761414 c.1608A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.34 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.21 rifampicin
rpoB 761451 p.Val549Thr missense_variant 0.21 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.29 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.26 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.29 rifampicin
rpoB 761501 c.1695G>C synonymous_variant 0.29 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.29 rifampicin
rpoB 761510 c.1704T>G synonymous_variant 0.38 rifampicin
rpoB 761528 c.1722C>T synonymous_variant 0.44 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.43 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761549 c.1743G>T synonymous_variant 0.52 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.52 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.53 rifampicin
rpoB 761615 c.1809A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.49 rifampicin
rpoB 761651 c.1845C>T synonymous_variant 0.45 rifampicin
rpoB 761655 p.Ala617Arg missense_variant 0.47 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.52 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.5 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.5 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.51 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.48 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsCG frameshift_variant&missense_variant 0.48 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761750 c.1944G>C synonymous_variant 0.6 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.63 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.64 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.58 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.56 rifampicin
rpoB 761819 c.2013G>C synonymous_variant 0.56 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.54 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.52 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.5 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.49 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761870 p.Asp688Glu missense_variant 0.45 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.45 rifampicin
rpoB 761882 c.2076C>G synonymous_variant 0.47 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.53 rifampicin
rpoB 761888 c.2082G>A synonymous_variant 0.55 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.59 rifampicin
rpoB 761912 c.2106T>G synonymous_variant 0.54 rifampicin
rpoB 761916 c.2110_2112delGACinsCA frameshift_variant&missense_variant 0.51 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.51 rifampicin
rpoB 761948 c.2142G>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.53 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.59 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762024 c.2218_2220delGTGinsAC frameshift_variant&missense_variant 0.61 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.65 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.61 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.59 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>T synonymous_variant 0.69 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.68 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.71 rifampicin
rpoB 762305 c.2499G>T synonymous_variant 0.7 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.66 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.6 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.64 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.59 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.55 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.58 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.56 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.56 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.59 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.56 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.51 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762452 c.-918G>A upstream_gene_variant 0.52 rifampicin
rpoC 762467 c.-903C>T upstream_gene_variant 0.54 rifampicin
rpoB 762491 c.2685T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.54 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.54 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.6 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.54 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.53 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.53 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.52 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.52 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.41 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.4 rifampicin
rpoC 762587 c.-783G>A upstream_gene_variant 0.4 rifampicin
rpoB 762599 c.2793T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762605 c.-765T>C upstream_gene_variant 0.33 rifampicin
rpoC 762608 c.-762C>G upstream_gene_variant 0.32 rifampicin
rpoC 762734 c.-636G>A upstream_gene_variant 0.3 rifampicin
rpoB 762759 p.Cys985Ala missense_variant 0.42 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 762785 c.-585C>T upstream_gene_variant 0.51 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.55 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762815 p.Met1003Ile missense_variant 0.49 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762820 p.Phe1005Tyr missense_variant 0.48 rifampicin
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762856 c.3050_3051insGAC disruptive_inframe_insertion 0.53 rifampicin
rpoB 762860 c.3056_3058delTTG disruptive_inframe_deletion 0.48 rifampicin
rpoC 762890 c.-480C>T upstream_gene_variant 0.57 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.62 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763115 c.-255T>G upstream_gene_variant 0.55 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.61 rifampicin
rpoB 763193 c.3387C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.61 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.64 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.65 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.63 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.62 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.61 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.6 rifampicin
rpoC 763259 c.-111G>C upstream_gene_variant 0.38 rifampicin
rpoC 763262 c.-108C>T upstream_gene_variant 0.34 rifampicin
rpoC 763375 c.6C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.29 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763409 c.40_42delCTTinsTG frameshift_variant&missense_variant 0.3 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.33 rifampicin
rpoC 763420 c.51G>C synonymous_variant 0.38 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.42 rifampicin Uncertain significance
rpoC 763430 c.61A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763435 c.66A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>G synonymous_variant 0.52 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763453 c.84C>G synonymous_variant 0.62 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>A synonymous_variant 0.68 rifampicin
rpoC 763484 c.115_117delCTTinsTG frameshift_variant&missense_variant 0.68 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>C synonymous_variant 0.64 rifampicin Not assoc w R
rpoC 763546 c.177A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.73 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.76 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.56 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.56 rifampicin
rpoC 763714 c.345G>A synonymous_variant 0.57 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763720 c.351G>C synonymous_variant 0.57 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.64 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.64 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.64 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.62 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763780 c.411C>G synonymous_variant 0.6 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.57 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.5 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.49 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.43 rifampicin
rpoC 763835 c.466_468delGCGinsAC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 763852 c.483C>G synonymous_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.35 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.37 rifampicin
rpoC 763879 c.510A>C synonymous_variant 0.37 rifampicin
rpoC 763885 c.516C>G synonymous_variant 0.38 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.4 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.43 rifampicin
rpoC 763903 c.534G>A synonymous_variant 0.49 rifampicin
rpoC 763921 c.552G>C synonymous_variant 0.59 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.62 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.61 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.62 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.6 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.6 rifampicin
rpoC 764011 c.642T>C synonymous_variant 0.59 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.52 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.55 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.56 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.56 rifampicin
rpoC 764077 c.708C>T synonymous_variant 0.58 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.58 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764167 c.798G>A synonymous_variant 0.49 rifampicin
rpoC 764169 p.Asn267Ser missense_variant 0.51 rifampicin Uncertain significance
rpoC 764179 c.810C>T synonymous_variant 0.58 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.54 rifampicin
rpoC 764195 p.Ser276Ala missense_variant 0.57 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.59 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.56 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.54 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.6 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.63 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.59 rifampicin
rpoC 764285 p.Gly306Thr missense_variant 0.59 rifampicin
rpoC 764311 c.942C>T synonymous_variant 0.6 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.6 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.6 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.69 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764392 c.1023C>T synonymous_variant 0.58 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764458 c.1089G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764494 c.1125G>A synonymous_variant 0.5 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.53 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764551 c.1182G>C synonymous_variant 0.76 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.72 rifampicin
rpoC 764578 c.1209C>T synonymous_variant 0.71 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.66 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.67 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764656 c.1287C>G synonymous_variant 0.66 rifampicin
rpoC 764716 c.1347G>T synonymous_variant 0.66 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.58 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.6 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.58 rifampicin
rpoC 764851 c.1482C>T synonymous_variant 0.56 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.53 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.52 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.65 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.64 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.44 rifampicin Not assoc w R
rpoC 764995 c.1626C>T synonymous_variant 0.56 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>A synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.54 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.5 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.46 rifampicin
rpoC 765142 c.1773G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765145 c.1776C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765367 c.1998C>A synonymous_variant 0.39 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.43 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.44 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.46 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.58 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.55 rifampicin
rpoC 765478 c.2109T>G synonymous_variant 0.52 rifampicin
rpoC 765493 c.2124G>C synonymous_variant 0.5 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.33 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.33 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.32 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.45 rifampicin
rpoC 765584 p.Pro739Ala missense_variant 0.41 rifampicin
rpoC 765590 p.Arg741Gly missense_variant 0.39 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.43 rifampicin
rpoC 765611 p.His748Ala missense_variant 0.37 rifampicin
rpoC 765619 c.2250G>A synonymous_variant 0.42 rifampicin
rpoC 765625 c.2256C>A synonymous_variant 0.4 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Glu missense_variant 0.56 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765740 p.Glu791Lys missense_variant 0.57 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.7 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.68 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.66 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.64 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765823 c.2454C>G synonymous_variant 0.65 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765868 c.2499G>A synonymous_variant 0.51 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.51 rifampicin Uncertain significance
rpoC 765883 c.2514C>G synonymous_variant 0.54 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.54 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.53 rifampicin
rpoC 765937 c.2568T>G synonymous_variant 0.49 rifampicin
rpoC 765940 c.2571A>G synonymous_variant 0.49 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.43 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766270 c.2901G>C synonymous_variant 0.47 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.47 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.5 rifampicin
rpoC 766291 c.2922G>C synonymous_variant 0.46 rifampicin
rpoC 766298 p.Thr977Val missense_variant 0.45 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.51 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.52 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.53 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.47 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.42 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.42 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.47 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.48 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.52 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.51 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.52 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.51 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.49 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766510 c.3141C>A synonymous_variant 0.52 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.48 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.4 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.39 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.42 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.44 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.43 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.49 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.5 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.47 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.45 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.36 rifampicin
rpoC 766652 c.3283_3285delTCCinsAT frameshift_variant&missense_variant 0.34 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.34 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.33 rifampicin
rpoC 766666 c.3297C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766667 p.Ser1100Ala missense_variant 0.39 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.39 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.33 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.35 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.41 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766792 c.3423C>T synonymous_variant 0.56 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766855 c.3486G>T synonymous_variant 0.6 rifampicin
rpoC 766861 c.3492G>T synonymous_variant 0.65 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.61 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.61 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.59 rifampicin
rpoC 766933 c.3564A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766942 c.3573C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>T synonymous_variant 0.64 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.63 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.58 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.55 rifampicin
rpoC 766984 c.3615G>T synonymous_variant 0.56 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>C synonymous_variant 0.54 rifampicin
rpoC 767035 c.3666G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.5 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>G synonymous_variant 0.6 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.54 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpS5 779609 c.-704C>T upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781164 c.-396T>C upstream_gene_variant 0.24 streptomycin
rpsL 781173 c.-387A>G upstream_gene_variant 0.24 streptomycin
rpsL 781174 c.-386C>A upstream_gene_variant 0.24 streptomycin
rpsL 781179 c.-381T>C upstream_gene_variant 0.27 streptomycin
rpsL 781189 c.-371T>C upstream_gene_variant 0.3 streptomycin
rpsL 781192 c.-368C>T upstream_gene_variant 0.31 streptomycin
rpsL 781197 c.-363A>G upstream_gene_variant 0.33 streptomycin
rpsL 781208 c.-352T>C upstream_gene_variant 0.33 streptomycin
rpsL 781217 c.-343_-342insCAT upstream_gene_variant 0.24 streptomycin
rpsL 781224 c.-336T>C upstream_gene_variant 0.24 streptomycin
rpsL 781230 c.-330T>C upstream_gene_variant 0.24 streptomycin
rpsL 781231 c.-329G>A upstream_gene_variant 0.24 streptomycin
rpsL 781234 c.-326G>C upstream_gene_variant 0.25 streptomycin
rpsL 781240 c.-320A>T upstream_gene_variant 0.24 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.3 streptomycin
rpsL 781592 c.33T>G synonymous_variant 0.4 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.4 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.38 streptomycin
rpsL 781608 c.49_51delAGTinsGA frameshift_variant&missense_variant 0.48 streptomycin Uncertain significance
rpsL 781628 c.69T>C synonymous_variant 0.61 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.61 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.65 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.66 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.65 streptomycin
rpsL 781673 c.114C>T synonymous_variant 0.66 streptomycin
rpsL 781679 c.120C>G synonymous_variant 0.67 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.62 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.59 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.58 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.58 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.58 streptomycin
rpsL 781733 c.174G>T synonymous_variant 0.61 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.6 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.61 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.62 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.64 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.67 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.63 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.65 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 0.65 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.63 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.64 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.63 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.66 streptomycin
rpsL 781889 c.330C>T synonymous_variant 0.68 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.67 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.7 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.66 streptomycin
rpsL 781913 c.354C>T synonymous_variant 0.67 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.69 streptomycin
rplC 800272 c.-537C>T upstream_gene_variant 0.26 linezolid
rplC 800275 c.-534T>G upstream_gene_variant 0.26 linezolid
rplC 800278 c.-531A>G upstream_gene_variant 0.26 linezolid
rplC 800287 c.-522_-521insAA upstream_gene_variant 0.29 linezolid
rplC 800302 c.-506delT upstream_gene_variant 0.35 linezolid
rplC 800307 c.-502T>G upstream_gene_variant 0.34 linezolid
rplC 800312 c.-497A>C upstream_gene_variant 0.34 linezolid
rplC 800315 c.-494A>G upstream_gene_variant 0.34 linezolid
rplC 800321 c.-488T>C upstream_gene_variant 0.33 linezolid
rplC 800516 c.-293G>C upstream_gene_variant 0.44 linezolid
rplC 800531 c.-278T>C upstream_gene_variant 0.52 linezolid
rplC 800543 c.-266C>T upstream_gene_variant 0.57 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.59 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.64 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.62 linezolid
rplC 800579 c.-230C>G upstream_gene_variant 0.66 linezolid
rplC 800585 c.-224T>G upstream_gene_variant 0.68 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.66 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.66 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.62 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.6 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.63 linezolid
rplC 800642 c.-167C>T upstream_gene_variant 0.64 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.59 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.62 linezolid
rplC 800666 c.-143C>T upstream_gene_variant 0.64 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.62 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.63 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.59 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.52 linezolid
rplC 800726 c.-83G>A upstream_gene_variant 0.48 linezolid
rplC 800738 c.-71T>G upstream_gene_variant 0.44 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.44 linezolid
rplC 800753 c.-56C>A upstream_gene_variant 0.41 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.4 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.4 linezolid
rplC 800765 c.-44G>C upstream_gene_variant 0.42 linezolid
rplC 800798 c.-11_-6delTGGACAinsCTGC upstream_gene_variant 0.29 linezolid
rplC 800814 c.6A>G synonymous_variant 0.31 linezolid
rplC 800815 c.7C>A synonymous_variant 0.31 linezolid
rplC 800829 c.21C>G synonymous_variant 0.34 linezolid
rplC 800832 c.24T>C synonymous_variant 0.34 linezolid
rplC 800841 c.33G>T synonymous_variant 0.35 linezolid
rplC 800844 c.36T>C synonymous_variant 0.32 linezolid
rplC 800856 c.48A>G synonymous_variant 0.29 linezolid
rplC 800865 c.57A>G synonymous_variant 0.2 linezolid
rplC 800946 c.138T>C synonymous_variant 0.34 linezolid
rplC 800962 c.154C>T synonymous_variant 0.37 linezolid
rplC 800967 c.159C>T synonymous_variant 0.36 linezolid
rplC 800970 c.162T>C synonymous_variant 0.38 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.4 linezolid
rplC 800985 c.177A>C synonymous_variant 0.38 linezolid
rplC 801008 p.Thr67Asn missense_variant 0.35 linezolid
rplC 801027 c.219C>G synonymous_variant 0.24 linezolid
rplC 801030 c.222C>T synonymous_variant 0.22 linezolid
rplC 801171 c.363A>G synonymous_variant 0.22 linezolid
rplC 801174 c.366T>C synonymous_variant 0.25 linezolid
rplC 801183 c.375C>G synonymous_variant 0.35 linezolid
rplC 801201 c.393C>T synonymous_variant 0.39 linezolid
rplC 801210 c.402T>G synonymous_variant 0.38 linezolid Not assoc w R - Interim
rplC 801222 c.414T>C synonymous_variant 0.38 linezolid
rplC 801228 c.420T>C synonymous_variant 0.37 linezolid
rplC 801231 c.423C>T synonymous_variant 0.38 linezolid
rplC 801240 c.432G>A synonymous_variant 0.38 linezolid
rplC 801243 c.435C>T synonymous_variant 0.38 linezolid
rplC 801246 c.438C>T synonymous_variant 0.38 linezolid
rplC 801267 c.459A>C synonymous_variant 0.33 linezolid
rplC 801285 c.477G>A synonymous_variant 0.22 linezolid
rplC 801300 c.492C>G synonymous_variant 0.25 linezolid
rplC 801312 c.504G>C synonymous_variant 0.27 linezolid
rplC 801321 c.513C>T synonymous_variant 0.24 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.26 linezolid
rplC 801330 c.522G>C synonymous_variant 0.25 linezolid
rplC 801337 p.Val177Thr missense_variant 0.24 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.25 linezolid
rplC 801357 c.549T>C synonymous_variant 0.34 linezolid
rplC 801399 c.591G>C synonymous_variant 0.31 linezolid
rplC 801400 c.592_594delGTTinsAC frameshift_variant&missense_variant 0.31 linezolid
rplC 801405 c.597T>C synonymous_variant 0.33 linezolid
rplC 801413 p.Thr202Asn missense_variant 0.31 linezolid
rplC 801417 c.609T>C synonymous_variant 0.33 linezolid
rplC 801420 c.612A>G synonymous_variant 0.33 linezolid
rplC 801438 c.630T>C synonymous_variant 0.3 linezolid
Rv1129c 1254301 c.234G>C synonymous_variant 0.33 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254310 c.225T>C synonymous_variant 0.35 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254313 p.Gln74His missense_variant 0.36 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254318 p.Ala73Pro missense_variant 0.38 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254321 p.Ser72Pro missense_variant 0.37 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254328 c.207T>C synonymous_variant 0.39 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254331 c.204G>T synonymous_variant 0.41 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254340 c.195T>C synonymous_variant 0.41 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254344 p.Leu64Ala missense_variant 0.45 moxifloxacin
levofloxacin
rifampicin
isoniazid
fbiC 1303500 c.570C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303537 c.607C>A synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303557 c.627G>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>A synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303663 c.733C>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303707 c.777G>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268His missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>T synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303746 p.Asp272Glu missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>A synonymous_variant 0.42 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303752 c.822A>G synonymous_variant 0.42 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303758 c.828G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303764 c.834C>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303789 p.Ile287Val missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303827 c.897A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303833 c.903C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304508 p.Glu526Asp missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304517 c.1587C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304544 p.Asp538Glu missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304556 c.1626C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304604 c.1674C>T synonymous_variant 0.48 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304610 c.1680C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304622 c.1692C>T synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304774 p.Ala615Val missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304826 c.1896G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304961 c.2031C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304967 c.2037G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>T synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304988 c.2058G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305006 p.Glu692Asp missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305369 c.2439G>A synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1305375 c.2445C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305390 c.2460C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305420 c.2490C>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
sigE 1364898 c.486C>T synonymous_variant 0.29 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.38 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.36 pyrazinamide
sigE 1364940 c.528C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
sigE 1364949 c.537C>T synonymous_variant 0.29 pyrazinamide
sigE 1364952 c.540A>G synonymous_variant 0.29 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.28 pyrazinamide
sigE 1364962 c.550_552delCCTinsGC frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
sigE 1364976 c.564T>G synonymous_variant 0.37 pyrazinamide
sigE 1364979 c.567C>G synonymous_variant 0.36 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.36 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.22 pyrazinamide
sigE 1365027 c.615C>T synonymous_variant 0.25 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.3 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.34 pyrazinamide
sigE 1365063 c.651A>G synonymous_variant 0.34 pyrazinamide
sigE 1365066 c.654G>C synonymous_variant 0.35 pyrazinamide
sigE 1365072 c.660G>C synonymous_variant 0.31 pyrazinamide
sigE 1365078 c.666C>A synonymous_variant 0.32 pyrazinamide
sigE 1365081 c.669G>C synonymous_variant 0.29 pyrazinamide
sigE 1365084 c.672G>C synonymous_variant 0.28 pyrazinamide
sigE 1365087 c.675A>G synonymous_variant 0.29 pyrazinamide
sigE 1365090 c.678T>C synonymous_variant 0.3 pyrazinamide
sigE 1365099 c.687A>C synonymous_variant 0.29 pyrazinamide
sigE 1365105 c.693C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
sigE 1365111 c.699C>G synonymous_variant 0.28 pyrazinamide
atpE 1460810 c.-235C>G upstream_gene_variant 0.37 bedaquiline
atpE 1460816 c.-229T>C upstream_gene_variant 0.34 bedaquiline
atpE 1460819 c.-226C>T upstream_gene_variant 0.31 bedaquiline
atpE 1460828 c.-217C>G upstream_gene_variant 0.24 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.22 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.21 bedaquiline
atpE 1461050 c.6C>T synonymous_variant 0.19 bedaquiline
atpE 1461074 c.30C>T synonymous_variant 0.37 bedaquiline
atpE 1461093 p.Met17Leu missense_variant 0.41 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.45 bedaquiline
atpE 1461107 c.63C>A synonymous_variant 0.45 bedaquiline
atpE 1461108 p.Ile22Val missense_variant 0.48 bedaquiline
atpE 1461118 p.Gly25Ala missense_variant 0.61 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.61 bedaquiline
atpE 1461161 c.117C>T synonymous_variant 0.57 bedaquiline
atpE 1461167 c.123G>C synonymous_variant 0.56 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.55 bedaquiline
atpE 1461173 c.129C>T synonymous_variant 0.57 bedaquiline
atpE 1461176 c.132G>A synonymous_variant 0.53 bedaquiline
atpE 1461179 c.135G>A synonymous_variant 0.52 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.5 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.54 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.56 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.51 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.48 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.4 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.33 bedaquiline
atpE 1461269 c.225C>A synonymous_variant 0.33 bedaquiline
atpE 1461275 c.231T>C synonymous_variant 0.3 bedaquiline
atpE 1461281 c.237C>A synonymous_variant 0.26 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80_81insG non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471932 n.87delAinsTG non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472309 n.464C>G non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472311 n.466C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>C non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606C>T non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472462 n.617T>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473122 n.1277_1278delTAinsGGT non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444_1445delTCinsGTTT non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473668 n.11C>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1473670 n.13A>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1473701 n.44A>G non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473782 n.125A>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474286 n.630delT non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474292 n.635_649delTTCCTCTCCGGAGGAinsGGT non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474715 n.1058T>G non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474716 n.1059A>G non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475217 n.1560T>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475239 n.1582A>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475240 n.1583C>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475241 n.1584C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475242 n.1585G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475253 n.1596T>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475257 n.1600C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475276 n.1619T>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475277 n.1620G>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475278 n.1621G>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475291 n.1634A>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475378 n.1721A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475379 n.1722G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475397 n.1740_1745delGCTCACinsTGGCG non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475413 n.1756A>G non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>C non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475484 n.1827A>G non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475499 n.1842C>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475762 n.2105G>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475764 n.2107_2108delAAinsTTGG non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1476033 n.2376T>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3033delC non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476693 n.3036delGinsCAA non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
inhA 1673607 c.-595T>C upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.37 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.4 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.41 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.44 ethionamide
isoniazid
fabG1 1673698 p.Ser87Ala missense_variant 0.55 ethionamide
isoniazid
inhA 1673712 c.-490A>G upstream_gene_variant 0.53 ethionamide
isoniazid
inhA 1673713 c.-489T>G upstream_gene_variant 0.54 ethionamide
isoniazid Uncertain significance
inhA 1673724 c.-478A>G upstream_gene_variant 0.55 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.5 ethionamide
isoniazid
fabG1 1673756 p.Glu106Val missense_variant 0.51 ethionamide
isoniazid
fabG1 1673767 p.Asn110Asp missense_variant 0.48 ethionamide
isoniazid
inhA 1673781 c.-421C>T upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673790 c.-412C>T upstream_gene_variant 0.41 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673826 c.-376C>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673829 p.Asn130Lys missense_variant 0.22 ethionamide
isoniazid
fabG1 1673830 p.Lys131Arg missense_variant 0.24 ethionamide
isoniazid
inhA 1673838 c.-364T>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673841 c.-361A>G upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673847 c.-355A>C upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1673853 p.Ile138Met missense_variant 0.34 ethionamide
isoniazid
inhA 1673862 c.-340C>G upstream_gene_variant 0.38 ethionamide
isoniazid
fabG1 1673870 p.Ser144Thr missense_variant 0.42 ethionamide
isoniazid
inhA 1673898 c.-304C>T upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673904 c.-298C>G upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673916 c.-286A>T upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673917 c.-285G>T upstream_gene_variant 0.38 ethionamide
isoniazid Uncertain significance
inhA 1673922 c.-280T>C upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1673955 c.-247G>A upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673958 c.-244G>A upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.43 ethionamide
isoniazid
inhA 1673964 c.-238C>T upstream_gene_variant 0.41 ethionamide
isoniazid
inhA 1673976 c.-226T>C upstream_gene_variant 0.4 ethionamide
isoniazid
inhA 1673985 c.-217C>A upstream_gene_variant 0.47 ethionamide
isoniazid
inhA 1674006 c.-196T>C upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1674012 c.-190C>G upstream_gene_variant 0.31 ethionamide
isoniazid
inhA 1674465 c.264C>T synonymous_variant 0.21 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674471 c.270G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674500 p.Gln100Pro missense_variant 0.33 ethionamide
isoniazid
inhA 1674503 p.Thr101Ser missense_variant 0.31 ethionamide
isoniazid
inhA 1674531 p.Asp110Glu missense_variant 0.44 ethionamide
isoniazid
inhA 1674537 c.336C>A synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.39 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674579 c.378G>A synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674585 c.384T>A synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.32 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.29 ethionamide
isoniazid
inhA 1674609 c.408G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674702 c.501G>A synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 0.27 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674741 c.540C>T synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674742 p.Lys181Pro missense_variant 0.29 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674813 c.612C>A synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674835 p.Gly212Ser missense_variant 0.32 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674839 p.Ala213Gly missense_variant 0.32 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.33 ethionamide
isoniazid
inhA 1674859 p.Glu220Gln missense_variant 0.36 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674876 c.675C>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674892 p.Asn231Asp missense_variant 0.28 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674900 c.699G>A synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674906 c.705G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674912 c.711G>A synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674915 c.714C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674966 c.765T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674978 c.777C>T synonymous_variant 0.32 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674990 c.789C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674996 c.795C>T synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674998 p.Thr266Asn missense_variant 0.3 ethionamide
isoniazid
inhA 1675010 c.809_*5delAGAACGCinsG frameshift_variant&stop_lost&splice_region_variant 0.33 ethionamide
isoniazid
rpsA 1833516 c.-26A>C upstream_gene_variant 0.36 pyrazinamide
rpsA 1833518 c.-24C>A upstream_gene_variant 0.42 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.59 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>A synonymous_variant 0.62 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.66 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.68 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.59 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.6 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.63 pyrazinamide
rpsA 1833628 c.87G>A synonymous_variant 0.64 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.7 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833670 c.129C>A synonymous_variant 0.67 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.65 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.66 pyrazinamide
rpsA 1833688 c.147C>T synonymous_variant 0.69 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.67 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.61 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.59 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.59 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.54 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.49 pyrazinamide
rpsA 1833794 c.253_255delGAGinsAA frameshift_variant&missense_variant 0.47 pyrazinamide Uncertain significance
rpsA 1833797 p.Val86Ile missense_variant 0.48 pyrazinamide Uncertain significance
rpsA 1833802 c.261A>G synonymous_variant 0.52 pyrazinamide
rpsA 1833806 c.265C>T synonymous_variant 0.55 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.63 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.62 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.64 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.66 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.63 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.63 pyrazinamide
rpsA 1833994 c.453G>T synonymous_variant 0.66 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.68 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834024 c.483G>T synonymous_variant 0.62 pyrazinamide
rpsA 1834087 c.546C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.38 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.26 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834189 c.648G>T synonymous_variant 0.37 pyrazinamide
rpsA 1834192 c.651C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.42 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.35 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGT synonymous_variant 0.35 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834330 c.789C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>A synonymous_variant 0.61 pyrazinamide
rpsA 1834357 c.816T>G synonymous_variant 0.6 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.57 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.51 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.54 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.53 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834531 c.990C>T synonymous_variant 0.55 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.57 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.58 pyrazinamide
rpsA 1834582 c.1041G>A synonymous_variant 0.64 pyrazinamide
rpsA 1834598 c.1057C>T synonymous_variant 0.64 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.65 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834615 c.1074C>T synonymous_variant 0.65 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.6 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.61 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.6 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.53 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.44 pyrazinamide
rpsA 1834766 p.Lys409Ala missense_variant 0.44 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.45 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.52 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.53 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.44 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.46 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.43 linezolid
tsnR 1853417 c.-189G>A upstream_gene_variant 0.42 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.4 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.42 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.43 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.43 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.5 linezolid
tsnR 1853453 c.-153G>T upstream_gene_variant 0.45 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.41 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.39 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.29 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.25 linezolid
tsnR 1853481 c.-125_-123delATCinsGG upstream_gene_variant 0.25 linezolid
tsnR 1853489 c.-117C>T upstream_gene_variant 0.25 linezolid
tsnR 1853492 c.-114G>C upstream_gene_variant 0.26 linezolid
tsnR 1853494 c.-112C>G upstream_gene_variant 0.26 linezolid
tsnR 1853516 c.-90C>G upstream_gene_variant 0.27 linezolid
tsnR 1853523 c.-83C>A upstream_gene_variant 0.29 linezolid
tsnR 1853528 c.-78G>T upstream_gene_variant 0.26 linezolid
tsnR 1853531 c.-75A>T upstream_gene_variant 0.21 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102203 c.840T>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.26 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102239 c.804C>A synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102246 p.Val266Thr missense_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102248 c.795C>T synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102251 c.792C>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102257 c.784_786delTCCinsCG frameshift_variant&synonymous_variant 0.29 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102266 c.777C>A synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102269 c.774C>G synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102407 c.636T>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102410 c.633G>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102413 c.630G>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102422 c.621C>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102427 p.Ser206Pro missense_variant 0.44 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102440 c.603C>T synonymous_variant 0.5 ethionamide
delamanid
isoniazid
ndh 2102460 p.His195Tyr missense_variant 0.54 ethionamide
delamanid
isoniazid
ndh 2102469 c.574C>T synonymous_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2102470 c.573G>A synonymous_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2102482 c.561A>G synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102494 c.549T>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
katG 2155225 p.Met296Gln missense_variant 0.3 isoniazid
katG 2155242 c.870T>C synonymous_variant 0.37 isoniazid
katG 2155251 c.861A>G synonymous_variant 0.24 isoniazid
katG 2155257 c.855C>A synonymous_variant 0.25 isoniazid
katG 2155263 c.849G>T synonymous_variant 0.21 isoniazid
katG 2155266 c.846T>C synonymous_variant 0.21 isoniazid
katG 2155272 c.840G>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289909 c.-668G>A upstream_gene_variant 1.0 pyrazinamide
kasA 2517917 c.-198G>T upstream_gene_variant 0.69 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.67 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.49 isoniazid
kasA 2517994 c.-121_-120delCCinsAG upstream_gene_variant 0.42 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.24 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.26 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.38 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.54 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.57 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.6 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.67 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.58 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.49 isoniazid
kasA 2518267 c.153C>G synonymous_variant 0.46 isoniazid
kasA 2518273 c.159G>A synonymous_variant 0.43 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.4 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.32 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.32 isoniazid
kasA 2518343 p.Met77Leu missense_variant 0.31 isoniazid
kasA 2518417 c.303G>C synonymous_variant 0.24 isoniazid
kasA 2518429 c.315A>C synonymous_variant 0.31 isoniazid
kasA 2518435 c.321G>C synonymous_variant 0.28 isoniazid
kasA 2518444 c.330T>C synonymous_variant 0.33 isoniazid
kasA 2518447 c.333T>C synonymous_variant 0.33 isoniazid
kasA 2518448 p.Val112Ile missense_variant 0.36 isoniazid
kasA 2518462 c.348A>G synonymous_variant 0.49 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.5 isoniazid
kasA 2518475 c.361A>C synonymous_variant 0.54 isoniazid
kasA 2518486 c.372G>A synonymous_variant 0.5 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.51 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.53 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.54 isoniazid
kasA 2518531 c.417G>A synonymous_variant 0.51 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.52 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.41 isoniazid
kasA 2518564 c.450C>T synonymous_variant 0.4 isoniazid
kasA 2518571 p.Val153Thr missense_variant 0.37 isoniazid
kasA 2518574 c.460_462delATCinsGT frameshift_variant&missense_variant 0.39 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.48 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.49 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.43 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.35 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.33 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.32 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.32 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.34 isoniazid
kasA 2518663 c.549T>G synonymous_variant 0.35 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.43 isoniazid
kasA 2518688 p.Val192Ile missense_variant 0.39 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.37 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.3 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.28 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.28 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.33 isoniazid
kasA 2518727 c.613C>T synonymous_variant 0.33 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.33 isoniazid
kasA 2518735 c.621C>T synonymous_variant 0.33 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.38 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.34 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.33 isoniazid
kasA 2518786 c.672G>A synonymous_variant 0.33 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.33 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.3 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.31 isoniazid
kasA 2518798 c.684G>T synonymous_variant 0.35 isoniazid
kasA 2518810 c.696G>A synonymous_variant 0.32 isoniazid
kasA 2518822 c.708C>T synonymous_variant 0.31 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.34 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.37 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.26 isoniazid
kasA 2518849 c.735G>C synonymous_variant 0.24 isoniazid
kasA 2518853 p.Leu247Val missense_variant 0.3 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.29 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.34 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.37 isoniazid
kasA 2518906 c.792A>T synonymous_variant 0.34 isoniazid
kasA 2518907 c.793T>C synonymous_variant 0.34 isoniazid
kasA 2518927 c.813C>T synonymous_variant 0.29 isoniazid
kasA 2518930 c.816G>C synonymous_variant 0.29 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.24 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.24 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.22 isoniazid
kasA 2519122 c.1008G>A synonymous_variant 0.25 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.26 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.26 isoniazid
kasA 2519161 c.1047G>C synonymous_variant 0.26 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.26 isoniazid
kasA 2519170 c.1056G>T synonymous_variant 0.28 isoniazid
kasA 2519171 c.1057_1059delCTCinsTG frameshift_variant&missense_variant 0.28 isoniazid
kasA 2519185 c.1071C>G synonymous_variant 0.28 isoniazid
kasA 2519188 c.1074G>C synonymous_variant 0.3 isoniazid
kasA 2519215 c.1101C>T synonymous_variant 0.35 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.32 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.32 isoniazid
kasA 2519234 c.1120_1122delGAGinsCC frameshift_variant&missense_variant 0.24 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.22 isoniazid
kasA 2519242 c.1128C>T synonymous_variant 0.22 isoniazid
kasA 2519245 c.1131T>C synonymous_variant 0.26 isoniazid
kasA 2519248 c.1134C>G synonymous_variant 0.29 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.33 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 0.35 isoniazid
kasA 2519266 c.1152C>G synonymous_variant 0.38 isoniazid
kasA 2519281 c.1167G>C synonymous_variant 0.37 isoniazid
kasA 2519284 c.1170C>T synonymous_variant 0.37 isoniazid
kasA 2519293 p.Asp393Glu missense_variant 0.31 isoniazid
kasA 2519297 p.Arg395Lys missense_variant 0.31 isoniazid
kasA 2519305 c.1191A>C synonymous_variant 0.28 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.28 isoniazid
kasA 2519332 c.1218C>G synonymous_variant 0.32 isoniazid
kasA 2519338 c.1224T>C synonymous_variant 0.29 isoniazid
kasA 2519341 c.1227G>C synonymous_variant 0.26 isoniazid
ahpC 2726582 c.390G>C synonymous_variant 0.28 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.34 isoniazid
ahpC 2726597 c.405C>G synonymous_variant 0.35 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.36 isoniazid
ahpC 2726621 c.429G>A synonymous_variant 0.38 isoniazid Not assoc w R - Interim
ahpC 2726627 c.435G>A synonymous_variant 0.38 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.37 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.35 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.38 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.33 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.3 isoniazid
folC 2746584 c.1015T>C synonymous_variant 0.35 para-aminosalicylic_acid
folC 2746609 c.990T>C synonymous_variant 0.43 para-aminosalicylic_acid
folC 2746612 c.987C>A synonymous_variant 0.41 para-aminosalicylic_acid
folC 2746615 c.984C>G synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747317 c.282C>A synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747341 c.256_258delGTCinsCG frameshift_variant&missense_variant 0.38 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.45 para-aminosalicylic_acid
folC 2747374 c.225G>A synonymous_variant 0.51 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747398 c.201C>T synonymous_variant 0.38 para-aminosalicylic_acid
folC 2747404 c.195G>C synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747410 c.187_189delAGCinsGA frameshift_variant&missense_variant 0.35 para-aminosalicylic_acid
folC 2747419 c.180C>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747422 c.177G>A synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747430 c.169C>T synonymous_variant 0.36 para-aminosalicylic_acid
Rv2477c 2782429 c.1614A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782432 c.1611G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin