TB-Profiler result

Run: ERR323056
Summary

Run ID: ERR323056

Sample name:

Date: 2024-10-04T14:39:32.486196

Number of reads: 1586241

Percentage reads mapped: 29.2

Median coverage: 33.0

Strain: lineage4.4.1.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1.2 Euro-American None 0.9
lineage4.4.1 Euro-American (S-type) None 0.99
lineage4 Euro-American None 1.0
La1.7.1 M.bovis None 0.09
lineage4.4 Euro-American None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155693 p.Ser140Asn missense_variant 0.48 isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.56 isoniazid Not assoc w R - Interim
dnaA 748 c.748_750delCTCinsTTG synonymous_variant 0.53 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.59 isoniazid
dnaA 766 c.766_767insCA frameshift_variant 0.62 isoniazid Uncertain significance
dnaA 769 c.770_771delCA frameshift_variant 0.62 isoniazid Uncertain significance
dnaA 793 p.Val265Ile missense_variant 0.7 isoniazid Uncertain significance
dnaA 801 c.801G>A synonymous_variant 0.75 isoniazid
dnaA 805 c.805T>C synonymous_variant 0.77 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.76 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.7 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.65 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.66 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.67 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.66 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.68 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.7 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.59 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.59 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.62 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.58 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.41 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.38 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.38 isoniazid
dnaA 939 c.939C>G synonymous_variant 0.4 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.42 isoniazid
dnaA 948 c.948C>T synonymous_variant 0.39 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.57 isoniazid
dnaA 1071 c.1071C>G synonymous_variant 0.6 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.67 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.73 isoniazid
dnaA 1110 c.1110T>G synonymous_variant 0.75 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.8 isoniazid
dnaA 1122 c.1122C>T synonymous_variant 0.82 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.76 isoniazid
dnaA 1149 c.1149C>G synonymous_variant 0.64 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.62 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.64 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.61 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.55 isoniazid Not assoc w R - Interim
gyrB 6100 c.861G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 6196 c.957C>A synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 6204 p.Ser322Thr missense_variant 0.79 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.82 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrB 6324 c.1085_1086insGTCG frameshift_variant 0.52 levofloxacin Uncertain significance
moxifloxacin
gyrB 6327 c.1090_1093delGAAC frameshift_variant 0.52 levofloxacin Uncertain significance
moxifloxacin
gyrA 6346 c.-956C>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6565 c.-737G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6589 c.-713G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6590 p.Arg451Thr missense_variant 0.31 levofloxacin
moxifloxacin
gyrB 6597 p.Ser453Cys missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>T upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554_1555delTAinsCCTG frameshift_variant&missense_variant 0.61 levofloxacin Uncertain significance
moxifloxacin
gyrB 6796 c.1558_1559delGG frameshift_variant 0.61 levofloxacin Uncertain significance
moxifloxacin
gyrB 6808 c.1569C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.6 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6896 p.Arg553Lys missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6926 c.-376_-374delTTGinsCTC upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6931 c.-371A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 6967 p.Asp577Leu missense_variant 0.69 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7015 c.-287G>A upstream_gene_variant 0.81 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>T upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.81 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 7100 c.1861T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7120 c.-182T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7343 c.42G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7460 c.159C>T synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7520 c.219G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7601 c.300C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7703 c.402G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7748 c.447A>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7820 c.519G>A synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>T synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7868 p.Ile189Met missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8126 c.825G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8156 c.855T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8282 c.981G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8306 c.1005C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8799 p.Ala500Pro missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8813 p.Asp504Glu missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8822 c.1521C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8840 c.1539C>T synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8951 c.1650G>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.61 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.49 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9077 c.1776C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9254 c.1953C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9266 p.Asp655Glu missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9284 c.1983T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9329 c.2028C>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9332 p.Asn677Lys missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCGC synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9369 c.2068C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.2 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.22 isoniazid
fgd1 491487 c.705C>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491491 p.Pro237Thr missense_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491496 c.714C>T synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.49 pretomanid
delamanid
clofazimine
fgd1 491520 c.738C>G synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fgd1 491536 c.754C>T synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.66 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.67 pretomanid
delamanid
clofazimine
fgd1 491574 c.792C>T synonymous_variant 0.8 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.78 pretomanid
delamanid
clofazimine
fgd1 491603 p.Ala274Glu missense_variant 0.77 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.7 pretomanid
delamanid
clofazimine
fgd1 491649 c.867C>T synonymous_variant 0.52 pretomanid
delamanid
clofazimine
mshA 575597 p.Ile84Val missense_variant 0.33 isoniazid
ethionamide
mshA 575620 c.273G>C synonymous_variant 0.4 isoniazid
ethionamide
mshA 575627 p.Ala94Thr missense_variant 0.37 isoniazid
ethionamide
mshA 575635 c.288A>G synonymous_variant 0.32 isoniazid
ethionamide
mshA 575641 c.294A>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.28 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575683 c.336G>C synonymous_variant 0.3 isoniazid
ethionamide
mshA 575686 c.339G>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575692 c.345G>A synonymous_variant 0.31 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.29 isoniazid Not assoc w R - Interim
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.25 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.25 isoniazid
ethionamide
mshA 575744 p.Ala133Thr missense_variant 0.26 isoniazid Uncertain significance
ethionamide
mshA 575749 c.402C>G synonymous_variant 0.28 isoniazid
ethionamide
mshA 575752 c.405G>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575764 c.417C>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575770 c.423G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575771 p.Val142Thr missense_variant 0.21 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.37 isoniazid
ethionamide
mshA 575804 c.457_459delTCGinsAGC synonymous_variant 0.45 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.5 isoniazid
ethionamide
mshA 575824 c.477T>A synonymous_variant 0.53 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.5 isoniazid
ethionamide
mshA 575863 c.516G>A synonymous_variant 0.49 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.49 isoniazid
ethionamide
mshA 575878 c.531A>G synonymous_variant 0.44 isoniazid
ethionamide
mshA 575887 c.540G>C synonymous_variant 0.36 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575905 c.558G>C synonymous_variant 0.2 isoniazid
ethionamide
ccsA 620379 c.489G>C synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.47 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620430 c.540C>T synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620433 c.543C>G synonymous_variant 0.45 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620439 c.549T>G synonymous_variant 0.45 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 620463 c.573C>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620598 c.708C>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620604 c.714C>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620605 p.Val239Ile missense_variant 0.26 kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
ccsA 620613 c.723C>T synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620619 c.729G>C synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620625 c.735A>C synonymous_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620631 c.741T>C synonymous_variant 0.51 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.62 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.64 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.6 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.63 kanamycin
capreomycin
amikacin
ccsA 620703 c.813G>C synonymous_variant 0.62 kanamycin
capreomycin
amikacin
ccsA 620712 c.822G>C synonymous_variant 0.62 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.53 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.55 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.49 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>C synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>G synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620760 c.870C>T synonymous_variant 0.41 kanamycin
capreomycin
amikacin
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.34 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.38 ethionamide
Rv0565c 657653 c.-183C>T upstream_gene_variant 0.38 ethionamide
Rv0565c 657670 c.-200A>G upstream_gene_variant 0.41 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.41 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.47 ethionamide
Rv0565c 657703 c.-233C>A upstream_gene_variant 0.47 ethionamide
hadA 731726 c.-204C>A upstream_gene_variant 0.32 isoniazid
hadA 731732 c.-198G>T upstream_gene_variant 0.37 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.53 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.51 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.54 isoniazid
hadA 731798 c.-132C>T upstream_gene_variant 0.49 isoniazid
hadA 731801 c.-129C>T upstream_gene_variant 0.47 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.49 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.4 isoniazid
hadA 731822 c.-108G>A upstream_gene_variant 0.37 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.42 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.48 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.51 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
nusG 734496 c.243G>A synonymous_variant 0.65 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.65 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.69 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.7 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.67 rifampicin
nusG 734574 c.321C>T synonymous_variant 0.66 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
nusG 734595 p.Asp114Glu missense_variant 0.58 rifampicin
nusG 734596 c.343_345delTTGinsCTC synonymous_variant 0.53 rifampicin
nusG 734600 p.Thr116Asn missense_variant 0.56 rifampicin Uncertain significance
nusG 734607 p.Asp118Glu missense_variant 0.55 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.55 rifampicin
nusG 734615 p.Ala121Gly missense_variant 0.5 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.44 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.39 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.35 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.45 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.52 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.52 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.49 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.49 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.47 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.53 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.53 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.49 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.47 rifampicin
nusG 734922 c.669C>T synonymous_variant 0.3 rifampicin
nusG 734925 c.672C>T synonymous_variant 0.27 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.26 rifampicin
nusG 734934 c.681G>C synonymous_variant 0.23 rifampicin
nusG 734937 c.684G>C synonymous_variant 0.24 rifampicin
nusG 734949 c.696T>C synonymous_variant 0.19 rifampicin
nusG 734950 p.Gly233Ser missense_variant 0.2 rifampicin
rpoB 760046 c.240G>C synonymous_variant 0.39 rifampicin
rpoB 760058 c.252C>G synonymous_variant 0.48 rifampicin
rpoB 760059 p.Tyr85Thr missense_variant 0.5 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.56 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.58 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.78 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.79 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760127 c.321C>T synonymous_variant 0.77 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.77 rifampicin Uncertain significance
rpoB 760142 c.336C>G synonymous_variant 0.72 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.74 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760304 c.498G>A synonymous_variant 0.75 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.76 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.75 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.76 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.74 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.73 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.79 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.74 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.73 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.73 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.75 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>C synonymous_variant 0.72 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.71 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.7 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.62 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760551 c.745_746delTCinsAG synonymous_variant 0.53 rifampicin
rpoB 760563 c.757delCinsAT frameshift_variant&synonymous_variant 0.33 rifampicin
rpoB 760566 p.Ser254Ala missense_variant 0.34 rifampicin
rpoB 760567 c.762delG frameshift_variant 0.33 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.45 rifampicin
rpoB 760595 c.789C>G synonymous_variant 0.47 rifampicin
rpoB 760611 c.805_807delTTGinsCTC synonymous_variant 0.52 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.77 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.68 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.71 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.49 rifampicin
rpoB 761300 c.1494G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.52 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.52 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.47 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 0.47 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.46 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.33 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761516 c.1710G>C synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.62 rifampicin
rpoB 761657 c.1851C>A synonymous_variant 0.59 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.51 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.49 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.38 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.25 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.7 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.71 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.7 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.72 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.74 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.75 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.73 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.72 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.63 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.67 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.69 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.67 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.65 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.65 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.64 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.64 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.65 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.68 rifampicin
rpoC 762390 c.-980C>T upstream_gene_variant 0.68 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.67 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.67 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.65 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.63 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.6 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.54 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.55 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762527 c.-843G>C upstream_gene_variant 0.51 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.48 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.49 rifampicin
rpoC 762537 c.-833_-831delTTGinsCTC upstream_gene_variant 0.49 rifampicin
rpoC 762560 c.-810A>T upstream_gene_variant 0.47 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.44 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.44 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.61 rifampicin Uncertain significance
rpoB 762923 c.3117C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.75 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.75 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.73 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.77 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.78 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.76 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.75 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763200 c.-170_-168delCTAinsTTG upstream_gene_variant 0.6 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.58 rifampicin
rpoC 763217 c.-153G>C upstream_gene_variant 0.59 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.57 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.57 rifampicin
rpoC 763232 c.-138C>T upstream_gene_variant 0.54 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.53 rifampicin
rpoB 763241 p.Glu1145Asp missense_variant 0.54 rifampicin
rpoC 763259 c.-111G>T upstream_gene_variant 0.41 rifampicin
rpoB 763265 c.3459G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763373 c.4_6delCTCinsTTA synonymous_variant 0.53 rifampicin
rpoC 763411 c.42T>C synonymous_variant 0.64 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.64 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCGT synonymous_variant 0.67 rifampicin
rpoC 763435 c.66A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763498 c.129G>A synonymous_variant 0.72 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.67 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.5 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.49 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.58 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.68 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.66 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>T synonymous_variant 0.51 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.51 rifampicin
rpoC 763781 p.Ser138Asp missense_variant 0.45 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.48 rifampicin
rpoC 763787 p.Asp140Asn missense_variant 0.49 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.52 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763831 c.462A>G synonymous_variant 0.44 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.33 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.3 rifampicin
rpoC 763844 p.Arg159Lys missense_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.37 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.37 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.35 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.37 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.37 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.37 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.3 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763903 c.534G>A synonymous_variant 0.27 rifampicin
rpoC 763921 c.552G>C synonymous_variant 0.29 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.4 rifampicin
rpoC 763940 p.Ala191Ser missense_variant 0.35 rifampicin Uncertain significance
rpoC 763947 p.Ala193Val missense_variant 0.38 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763991 p.Ile208Leu missense_variant 0.41 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.42 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.4 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.3 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.36 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.38 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.44 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.44 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.46 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.46 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764153 p.Gln262Lys missense_variant 0.41 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.37 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764227 c.858G>T synonymous_variant 0.29 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.29 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.31 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.32 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.31 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.32 rifampicin
rpoC 764278 c.909_912delACAGinsGACCAA frameshift_variant&missense_variant 0.29 rifampicin
rpoC 764283 c.916_917delGG frameshift_variant 0.29 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.53 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.52 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.61 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.61 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.56 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.43 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.32 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.42 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.44 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.43 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.58 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.57 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.56 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.71 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.82 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.71 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.74 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.75 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.77 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.78 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.74 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.73 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.73 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.64 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>C synonymous_variant 0.49 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.53 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.53 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765376 c.2007C>T synonymous_variant 0.23 rifampicin
rpoC 765379 c.2010G>C synonymous_variant 0.22 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.21 rifampicin Uncertain significance
rpoC 765394 c.2025G>A synonymous_variant 0.23 rifampicin
rpoC 765403 c.2034_2035insAT frameshift_variant 0.24 rifampicin
rpoC 765406 c.2037G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765407 c.2039_2040delGT frameshift_variant 0.25 rifampicin
rpoC 765419 p.Val684Ile missense_variant 0.41 rifampicin Uncertain significance
rpoC 765425 p.Lys686Glu missense_variant 0.42 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.49 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.47 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.49 rifampicin Uncertain significance
rpoC 765493 c.2124G>C synonymous_variant 0.52 rifampicin
rpoC 765496 c.2127C>G synonymous_variant 0.54 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 0.42 rifampicin Uncertain significance
rpoC 765547 c.2178C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.33 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.36 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.36 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.35 rifampicin
rpoC 765591 p.Arg741Gln missense_variant 0.3 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.28 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.26 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.25 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.35 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.41 rifampicin
rpoC 765820 c.2451G>C synonymous_variant 0.43 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.43 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.62 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.63 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.66 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.46 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCTT synonymous_variant 0.45 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.35 rifampicin
rpoC 766012 c.2643C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.34 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.36 rifampicin
rpoC 766061 p.Val898Asn missense_variant 0.32 rifampicin
rpoC 766067 p.Glu900Thr missense_variant 0.32 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.26 rifampicin
rpoC 766095 p.Thr909Ser missense_variant 0.2 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.23 rifampicin
rpoC 766299 p.Thr977Met missense_variant 0.21 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.38 rifampicin
rpoC 766336 c.2967C>G synonymous_variant 0.47 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.45 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766354 c.2985C>G synonymous_variant 0.44 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.52 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.56 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.57 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.54 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.54 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.53 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.62 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.64 rifampicin
rpoC 766480 c.3111C>T synonymous_variant 0.59 rifampicin
rpoC 766483 c.3114G>T synonymous_variant 0.55 rifampicin
rpoC 766486 c.3117A>C synonymous_variant 0.58 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.56 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.54 rifampicin
rpoC 766513 c.3144C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766516 c.3147C>G synonymous_variant 0.51 rifampicin
rpoC 766517 p.Thr1050Ser missense_variant 0.52 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.51 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.51 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.58 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.56 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.59 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.56 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.65 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.64 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.62 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.61 rifampicin
rpoC 766634 p.Phe1089Ile missense_variant 0.61 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.55 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.5 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.47 rifampicin
rpoC 766658 p.Arg1097Gly missense_variant 0.47 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.46 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.37 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.33 rifampicin
rpoC 766694 p.Gln1109Asp missense_variant 0.33 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.47 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766720 c.3351C>T synonymous_variant 0.56 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.61 rifampicin
rpoC 766732 c.3363G>C synonymous_variant 0.62 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.62 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.65 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.64 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.64 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.68 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.68 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.26 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.71 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.66 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.66 rifampicin
rpoC 767197 c.3828G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>T synonymous_variant 0.64 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767254 c.3885G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.44 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.3 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.28 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775946 c.2535C>G synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.35 bedaquiline
clofazimine
mmpL5 775975 p.Leu836Met missense_variant 0.41 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.41 bedaquiline
clofazimine
mmpL5 775991 c.2490G>A synonymous_variant 0.29 bedaquiline
clofazimine
mmpL5 775996 p.Ile829Val missense_variant 0.28 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 775997 c.2484T>C synonymous_variant 0.26 bedaquiline
clofazimine
mmpL5 776000 p.Leu827Ile missense_variant 0.22 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776015 p.Ile822Leu missense_variant 0.25 bedaquiline
clofazimine
mmpL5 776048 c.2433G>A synonymous_variant 0.37 bedaquiline
clofazimine
mmpL5 776053 c.2428T>C synonymous_variant 0.36 bedaquiline
clofazimine
mmpL5 776056 p.Val809Leu missense_variant 0.36 bedaquiline
clofazimine
mmpL5 776060 c.2421C>A synonymous_variant 0.37 bedaquiline
clofazimine
mmpL5 776063 c.2418C>G synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 776075 c.2406C>G synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 776078 c.2403C>G synonymous_variant 0.39 bedaquiline
clofazimine
mmpL5 776087 p.Val798Met missense_variant 0.42 bedaquiline
clofazimine
mmpL5 776090 c.2391C>T synonymous_variant 0.42 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 0.43 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776654 c.1827A>C synonymous_variant 0.37 bedaquiline
clofazimine
mmpL5 776681 c.1800G>C synonymous_variant 0.49 bedaquiline
clofazimine
mmpL5 776682 c.1798_1799insGA frameshift_variant 0.44 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776686 c.1793_1794delGG frameshift_variant 0.38 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776704 p.Asp593Asn missense_variant 0.46 bedaquiline
clofazimine
mmpL5 776715 p.Lys589Pro missense_variant 0.44 bedaquiline
clofazimine
mmpL5 776729 c.1752C>T synonymous_variant 0.35 bedaquiline
clofazimine
mmpL5 776733 p.Ser583Asn missense_variant 0.4 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776741 c.1740C>G synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 777094 c.1387T>C synonymous_variant 0.28 bedaquiline
clofazimine
mmpL5 777095 c.1386T>C synonymous_variant 0.28 bedaquiline
clofazimine
mmpL5 777101 c.1380C>G synonymous_variant 0.25 bedaquiline
clofazimine
mmpL5 777104 c.1377G>C synonymous_variant 0.25 bedaquiline
clofazimine
mmpL5 777107 c.1374T>C synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 777110 c.1371T>C synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 777115 p.Met456Leu missense_variant 0.24 bedaquiline
clofazimine
mmpL5 777116 c.1365C>T synonymous_variant 0.25 bedaquiline
clofazimine
mmpL5 777126 p.Ser452Thr missense_variant 0.24 bedaquiline
clofazimine
mmpL5 777128 c.1353A>G synonymous_variant 0.22 bedaquiline
clofazimine
mmpL5 777142 p.Val447Leu missense_variant 0.31 bedaquiline
clofazimine
mmpL5 777154 p.Met443Leu missense_variant 0.41 bedaquiline
clofazimine
mmpL5 777161 p.Gln440Asn missense_variant 0.39 bedaquiline
clofazimine
mmpL5 777170 c.1311T>C synonymous_variant 0.35 bedaquiline
clofazimine
mmpL5 777173 c.1308C>G synonymous_variant 0.34 bedaquiline
clofazimine
mmpL5 777176 p.Glu435Asp missense_variant 0.39 bedaquiline
clofazimine
mmpL5 777188 c.1293T>C synonymous_variant 0.43 bedaquiline
clofazimine
mmpL5 777194 c.1287A>G synonymous_variant 0.42 bedaquiline
clofazimine
mmpL5 777206 c.1275A>G synonymous_variant 0.42 bedaquiline
clofazimine
mmpL5 777209 c.1272C>T synonymous_variant 0.42 bedaquiline
clofazimine
mmpL5 777578 c.903C>G synonymous_variant 0.22 bedaquiline
clofazimine
mmpS5 778510 p.Asp132Asn missense_variant 0.22 bedaquiline
clofazimine
mmpL5 778522 c.-42A>C upstream_gene_variant 0.34 bedaquiline
clofazimine
mmpL5 778530 c.-50C>A upstream_gene_variant 0.32 bedaquiline
clofazimine
mmpL5 778537 c.-57G>A upstream_gene_variant 0.34 bedaquiline
clofazimine
mmpL5 778540 c.-60G>C upstream_gene_variant 0.35 bedaquiline
clofazimine
mmpL5 778543 c.-63A>G upstream_gene_variant 0.34 bedaquiline
clofazimine
mmpS5 778547 p.Gly120Asp missense_variant 0.35 bedaquiline
clofazimine
mmpS5 778556 p.Thr117Ile missense_variant 0.34 bedaquiline
clofazimine
mmpL5 778561 c.-81A>G upstream_gene_variant 0.38 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781559 c.-1G>C upstream_gene_variant 0.52 streptomycin
rpsL 781572 p.Gln5Asn missense_variant 0.55 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.71 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.72 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.74 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.77 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.77 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.79 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.8 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.78 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.8 streptomycin
rpsL 781676 c.117C>G synonymous_variant 0.83 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.83 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.77 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.79 streptomycin
rpsL 781718 c.159C>A synonymous_variant 0.77 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.76 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.75 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.74 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.75 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.75 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.72 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.73 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.73 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.73 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.72 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.72 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.72 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.71 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.7 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.73 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.64 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.61 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.61 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.65 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.65 streptomycin
rpsL 781895 c.336G>A synonymous_variant 0.63 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.63 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.66 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.66 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.67 streptomycin Uncertain significance
rplC 800603 c.-206G>C upstream_gene_variant 0.23 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.38 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.46 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.56 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.6 linezolid
rplC 800690 c.-119C>G upstream_gene_variant 0.72 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.72 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.73 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.72 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.7 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.67 linezolid
rplC 800780 c.-29C>G upstream_gene_variant 0.46 linezolid
rplC 801387 c.579G>C synonymous_variant 0.28 linezolid
rplC 801396 c.588T>C synonymous_variant 0.29 linezolid
rplC 801399 c.591G>C synonymous_variant 0.3 linezolid
rplC 801400 p.Val198Ile missense_variant 0.29 linezolid
rplC 801405 c.597T>G synonymous_variant 0.29 linezolid
rplC 801408 c.600C>A synonymous_variant 0.3 linezolid
rplC 801413 p.Thr202Asn missense_variant 0.3 linezolid
rplC 801426 c.618C>G synonymous_variant 0.27 linezolid
rplC 801438 c.630T>C synonymous_variant 0.28 linezolid
rplC 801441 c.633G>A synonymous_variant 0.28 linezolid
rplC 801447 c.639A>G synonymous_variant 0.28 linezolid
rplC 801453 c.645T>C synonymous_variant 0.27 linezolid
fbiC 1303500 c.570C>T synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303509 c.579G>C synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fbiC 1303531 p.Met201Leu missense_variant 0.74 pretomanid
delamanid
clofazimine
fbiC 1303548 c.618G>C synonymous_variant 0.72 pretomanid
delamanid
clofazimine
fbiC 1303551 c.621G>C synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1303554 c.624G>A synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.73 pretomanid
delamanid
clofazimine
fbiC 1303581 c.651G>C synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.71 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.68 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>G synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303689 c.759T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>A synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303716 c.786C>A synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303722 c.792C>T synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Thr missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303740 c.810C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303746 p.Asp272Glu missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303750 p.Leu274Met missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303755 c.825T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303915 p.Met329Leu missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303938 c.1008C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303953 c.1023C>T synonymous_variant 0.26 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303956 c.1026A>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303973 p.Gly348Ala missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303998 c.1068T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304682 c.1752C>T synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>G synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.55 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304763 c.1833C>G synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fbiC 1304766 c.1836C>G synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>A synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.44 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.26 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304970 c.2040G>C synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1305006 p.Glu692Asp missense_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1305007 p.Ile693Val missense_variant 0.4 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiC 1305012 c.2082G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1305043 c.2113_2115delTCAinsAGT synonymous_variant 0.35 pretomanid
delamanid
clofazimine
sigE 1364667 c.255T>C synonymous_variant 0.35 pyrazinamide
sigE 1364676 c.264C>G synonymous_variant 0.35 pyrazinamide
sigE 1364682 c.270G>A synonymous_variant 0.34 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.35 pyrazinamide
sigE 1364694 c.282G>C synonymous_variant 0.36 pyrazinamide
sigE 1364697 c.285G>C synonymous_variant 0.31 pyrazinamide
sigE 1364703 c.291G>C synonymous_variant 0.31 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.33 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.33 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.41 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.52 pyrazinamide
sigE 1364751 c.339C>T synonymous_variant 0.51 pyrazinamide
sigE 1364760 c.348C>G synonymous_variant 0.41 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.35 pyrazinamide
sigE 1364767 c.355_357delAGGinsCGC synonymous_variant 0.34 pyrazinamide
sigE 1364772 c.360G>C synonymous_variant 0.34 pyrazinamide
sigE 1364778 c.366G>T synonymous_variant 0.34 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.32 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.29 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.32 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.32 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.36 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.39 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.41 pyrazinamide
sigE 1364859 c.447C>G synonymous_variant 0.45 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.47 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.46 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.47 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.63 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.43 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.4 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.4 pyrazinamide
sigE 1364931 c.519C>G synonymous_variant 0.37 pyrazinamide
sigE 1364942 p.Tyr177Phe missense_variant 0.31 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.28 pyrazinamide
atpE 1461042 c.-2delA upstream_gene_variant 0.33 bedaquiline
atpE 1461050 c.6C>T synonymous_variant 0.36 bedaquiline
atpE 1461056 c.12T>A synonymous_variant 0.45 bedaquiline
atpE 1461065 c.21C>T synonymous_variant 0.53 bedaquiline
atpE 1461071 c.27C>T synonymous_variant 0.58 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.61 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.64 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.66 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.59 bedaquiline
atpE 1461152 c.108C>T synonymous_variant 0.59 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.59 bedaquiline Uncertain significance
atpE 1461167 c.123G>C synonymous_variant 0.51 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.49 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.41 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.38 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.39 bedaquiline
atpE 1461188 c.144G>C synonymous_variant 0.39 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.38 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.23 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.23 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.23 bedaquiline
rrs 1471514 n.-332A>G upstream_gene_variant 0.44 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471517 n.-329T>C upstream_gene_variant 0.39 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.78 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601_604delTCTC non_coding_transcript_exon_variant 0.83 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472451 n.606_607insCGGG non_coding_transcript_exon_variant 0.83 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473833 n.176G>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_632delTCCinsCTCG non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474293 n.637_647delCCTCTCCGGAG non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474306 n.649A>C non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052_1053insACAAG non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474711 n.1055_1058delGTGT non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475232 n.1575A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475286 n.1629T>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475382 n.1725A>C non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1972_1973insC non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476746 n.3089T>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476755 n.3098G>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476757 n.3100T>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
inhA 1673679 c.-523T>C upstream_gene_variant 0.38 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673710 c.-492_-490delCTAinsATC upstream_gene_variant 0.41 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsAA upstream_gene_variant 0.44 isoniazid
ethionamide
inhA 1673728 c.-474_-472delCTCinsTTG upstream_gene_variant 0.53 isoniazid
ethionamide
inhA 1673748 c.-454A>C upstream_gene_variant 0.52 isoniazid
ethionamide
inhA 1673749 c.-453_-451delAAGinsCGT upstream_gene_variant 0.52 isoniazid
ethionamide
inhA 1673757 c.-445G>A upstream_gene_variant 0.49 isoniazid
ethionamide
inhA 1673758 c.-444A>G upstream_gene_variant 0.47 isoniazid
ethionamide
inhA 1673799 c.-403T>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673802 c.-400A>G upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673805 c.-397G>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673901 c.-301A>C upstream_gene_variant 0.3 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.3 isoniazid
ethionamide
inhA 1673916 c.-286A>T upstream_gene_variant 0.3 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.3 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.3 isoniazid
ethionamide
inhA 1673925 c.-277C>T upstream_gene_variant 0.31 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673931 c.-271C>G upstream_gene_variant 0.36 isoniazid
ethionamide
inhA 1673941 c.-261_-259delGCCinsTCG upstream_gene_variant 0.41 isoniazid
ethionamide
inhA 1673946 c.-256C>T upstream_gene_variant 0.42 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.41 isoniazid
ethionamide
inhA 1673967 c.-235G>C upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1673973 c.-229G>C upstream_gene_variant 0.24 isoniazid Uncertain significance
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1674015 c.-187C>T upstream_gene_variant 0.27 isoniazid Uncertain significance
ethionamide
inhA 1674096 c.-106G>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1674098 c.-104T>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1674102 c.-100C>G upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1674114 c.-88T>A upstream_gene_variant 0.35 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674120 c.-82G>A upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674123 c.-79T>C upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674126 c.-76G>C upstream_gene_variant 0.34 isoniazid
ethionamide
inhA 1674127 c.-75A>G upstream_gene_variant 0.34 isoniazid
ethionamide
inhA 1674132 c.-70T>C upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674136 c.-66T>G upstream_gene_variant 0.35 isoniazid
ethionamide
inhA 1674171 c.-31T>C upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1674428 p.Gly76Asp missense_variant 0.27 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674435 c.234G>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674443 p.Ala81Val missense_variant 0.41 isoniazid
ethionamide
inhA 1674450 c.249G>C synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674452 p.Ala84Glu missense_variant 0.44 isoniazid
ethionamide
inhA 1674462 c.261G>A synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674471 c.270G>T synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674474 c.273G>C synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.55 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.59 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.62 isoniazid
ethionamide
inhA 1674513 c.312C>T synonymous_variant 0.71 isoniazid
ethionamide
inhA 1674534 c.333G>C synonymous_variant 0.66 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.67 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.67 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.67 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.68 isoniazid
ethionamide
inhA 1674550 p.Ser117Ala missense_variant 0.7 isoniazid
ethionamide
inhA 1674576 c.375T>C synonymous_variant 0.66 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.57 isoniazid
ethionamide
inhA 1674585 c.384T>G synonymous_variant 0.56 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.59 isoniazid
ethionamide
inhA 1674618 c.417C>T synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674621 c.420C>G synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674628 p.Ser143Gly missense_variant 0.49 isoniazid
ethionamide
inhA 1674639 c.438C>T synonymous_variant 0.48 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674656 p.Ser152Thr missense_variant 0.32 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674663 c.462G>C synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674669 c.468G>C synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674702 c.501G>A synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674703 c.502_504delTTGinsCTC synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674714 c.513C>G synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674718 c.517_519delAGGinsCGC synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674726 c.525G>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674745 p.Tyr182Val missense_variant 0.48 isoniazid
ethionamide
inhA 1674756 c.555T>G synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674765 c.564C>T synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674792 c.591G>C synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.46 isoniazid
ethionamide
inhA 1674813 c.612C>T synonymous_variant 0.53 isoniazid
ethionamide
inhA 1674819 c.618G>C synonymous_variant 0.56 isoniazid
ethionamide
inhA 1674825 c.624C>T synonymous_variant 0.55 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674828 p.Glu209Asp missense_variant 0.57 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.62 isoniazid
ethionamide
inhA 1674858 c.657G>A synonymous_variant 0.67 isoniazid
ethionamide
inhA 1674879 c.678T>A synonymous_variant 0.62 isoniazid
ethionamide
inhA 1674883 p.Ile228Leu missense_variant 0.6 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.55 isoniazid
ethionamide
inhA 1674909 c.708G>C synonymous_variant 0.55 isoniazid
ethionamide
inhA 1674934 p.Leu245Val missense_variant 0.43 isoniazid
ethionamide
inhA 1674942 c.741T>G synonymous_variant 0.38 isoniazid
ethionamide
rpsA 1833537 c.-5_-1delACAATinsCCAC upstream_gene_variant 0.22 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.32 pyrazinamide
rpsA 1833554 p.Thr5Ser missense_variant 0.38 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.47 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.45 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.44 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.48 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.48 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.51 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.53 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.55 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.44 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.47 pyrazinamide
rpsA 1833694 c.153G>A synonymous_variant 0.49 pyrazinamide
rpsA 1833700 c.159C>A synonymous_variant 0.54 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.32 pyrazinamide
rpsA 1833739 c.198C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.39 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.41 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.43 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.46 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.61 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.62 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.7 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.76 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.76 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.8 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.77 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.79 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.73 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.77 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.77 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.41 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.49 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>A synonymous_variant 0.58 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834298 p.Gln253Thr missense_variant 0.63 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.63 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.72 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.74 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.74 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.72 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.69 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.68 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.65 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834556 p.Ala339Gln missense_variant 0.62 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.64 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.7 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.66 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.62 pyrazinamide
rpsA 1834678 c.1137C>T synonymous_variant 0.67 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834705 c.1164C>G synonymous_variant 0.63 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.45 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.27 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.56 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.54 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.52 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.52 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.49 linezolid
tsnR 1853390 c.-216G>T upstream_gene_variant 0.5 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.48 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.51 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.5 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.5 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.46 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.43 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.42 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.4 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.4 linezolid
tsnR 1853480 c.-126G>C upstream_gene_variant 0.41 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.41 linezolid
tsnR 1853490 c.-116_-114delCCGinsGCC upstream_gene_variant 0.42 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.42 linezolid
tsnR 1853516 c.-90C>G upstream_gene_variant 0.29 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102218 c.825C>G synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2102227 c.816C>G synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2102233 c.810G>A synonymous_variant 0.23 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2102242 c.801G>T synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2102245 p.Val266Leu missense_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2102248 p.Thr265Asn missense_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2102259 p.Ser262Pro missense_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2102269 c.774C>G synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2102990 p.Val18Ala missense_variant 1.0 isoniazid Not assoc w R
delamanid Uncertain significance
ethionamide Uncertain significance
katG 2155626 c.486G>C synonymous_variant 0.29 isoniazid
katG 2155632 c.480A>C synonymous_variant 0.39 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.44 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.43 isoniazid Uncertain significance
katG 2155655 p.Lys153Gln missense_variant 0.4 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.4 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.45 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.46 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.43 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.33 isoniazid
katG 2155752 c.360C>T synonymous_variant 0.23 isoniazid
katG 2155765 p.His116Phe missense_variant 0.27 isoniazid
PPE35 2167770 p.Ser948Ile missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169840 p.Gly258Asp missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170066 p.Ala183Thr missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.63 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.54 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.52 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.33 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.25 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.42 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.64 isoniazid
kasA 2518156 c.42T>C synonymous_variant 0.66 isoniazid
kasA 2518159 c.45G>C synonymous_variant 0.66 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.63 isoniazid
kasA 2518180 c.66G>C synonymous_variant 0.65 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.63 isoniazid
kasA 2518193 p.Pro27Ala missense_variant 0.62 isoniazid
kasA 2518219 c.105T>G synonymous_variant 0.67 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.64 isoniazid
kasA 2518245 p.His44Arg missense_variant 0.48 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.42 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.41 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.27 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.35 isoniazid
kasA 2519143 c.1029G>C synonymous_variant 0.26 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.37 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.37 isoniazid
kasA 2519180 p.Val356Ile missense_variant 0.35 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.37 isoniazid
kasA 2519203 c.1089C>G synonymous_variant 0.36 isoniazid
kasA 2519206 c.1092C>T synonymous_variant 0.38 isoniazid
kasA 2519224 c.1110C>A synonymous_variant 0.36 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.32 isoniazid
Rv2477c 2782426 c.1617G>A synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782431 p.Glu538Gln missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782453 c.1590C>T synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.67 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782495 p.Asp516Ser missense_variant 0.63 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.66 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2782504 c.1539G>A synonymous_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.51 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.52 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.53 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783837 p.Thr69Ser missense_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783842 c.201C>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783847 p.Thr66Pro missense_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783848 c.195C>G synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783875 p.Lys56Thr missense_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783947 c.96C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859739 p.Ala227Ser missense_variant 0.21 bedaquiline
clofazimine
pepQ 2859744 c.675G>C synonymous_variant 0.2 bedaquiline
clofazimine
pepQ 2859747 c.672C>G synonymous_variant 0.21 bedaquiline
clofazimine
pepQ 2859750 c.669C>T synonymous_variant 0.19 bedaquiline
clofazimine
pepQ 2859774 c.645C>T synonymous_variant 0.18 bedaquiline
clofazimine
pepQ 2860213 p.Pro69Leu missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
ribD 2986868 c.30T>C synonymous_variant 0.97 para-aminosalicylic_acid
Rv2752c 3065026 p.Arg389Lys missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065031 c.1161G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065052 c.1140G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065055 c.1137T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065070 c.1122C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065154 c.1038G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065186 c.1006T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065187 p.Val335Ile missense_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065193 c.999C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065196 c.996T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065202 c.990T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065205 c.987T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065210 c.982T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065223 c.969T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065229 c.963G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065232 c.960T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065241 c.951A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065249 c.943T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067754 c.192C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073950 c.522G>C synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3073971 c.501C>T synonymous_variant 0.61 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.61 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3073992 c.478_480delAGCinsTCG synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3073997 c.475C>T synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.55 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.43 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.36 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074087 p.Ile129Leu missense_variant 0.32 para-aminosalicylic_acid
thyA 3074089 p.Ile128Asn missense_variant 0.3 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.28 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625240 c.-330T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625243 c.-333T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625251 c.-341C>T upstream_gene_variant 0.37 rifampicin
bedaquiline
lpqB 3625255 c.-345T>C upstream_gene_variant 0.38 rifampicin
bedaquiline
lpqB 3625258 c.-348G>T upstream_gene_variant 0.37 rifampicin
bedaquiline
lpqB 3625270 c.-360G>A upstream_gene_variant 0.42 rifampicin
bedaquiline
lpqB 3625276 c.-366C>G upstream_gene_variant 0.42 rifampicin
bedaquiline
lpqB 3625279 c.-369C>G upstream_gene_variant 0.43 rifampicin
bedaquiline
lpqB 3625282 c.-372C>G upstream_gene_variant 0.45 rifampicin
bedaquiline
lpqB 3625291 c.-381A>G upstream_gene_variant 0.42 rifampicin
bedaquiline
lpqB 3625294 c.-384C>T upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3625324 p.His430Arg missense_variant 0.27 rifampicin
bedaquiline
mtrB 3625687 c.927G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625690 c.-780T>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625701 c.911_912delGC frameshift_variant 0.25 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625708 c.906delCinsTGT frameshift_variant&synonymous_variant 0.26 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625729 c.885A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625732 c.882C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>G upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.33 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625765 p.Ser283Gln missense_variant 0.22 rifampicin
bedaquiline
lpqB 3625795 c.-885G>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625813 c.801C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626684 c.-71G>A upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3626704 c.-91C>T upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrA 3626711 p.Thr213Gln missense_variant 0.36 rifampicin
bedaquiline
mtrB 3626723 c.-110C>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrB 3626738 c.-125G>A upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrA 3626741 c.609C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626749 c.601C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3626750 c.-137T>G upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrB 3626773 c.-160C>T upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGT upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3626783 c.-170C>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3626786 c.-173A>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626843 c.-230G>A upstream_gene_variant 0.49 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3626879 c.-266G>C upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrA 3626906 p.Asn148Gln missense_variant 0.37 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627272 c.-659G>C upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3627287 c.-674C>G upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627301 c.-688T>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrA 3627305 p.Ala15Pro missense_variant 0.4 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627320 c.-707C>T upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3627325 c.-712T>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrB 3627360 c.-747G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627365 c.-752C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
fbiB 3641968 p.Ala145Gly missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiB 3641970 p.Val146Ile missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiB 3642011 c.477C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3642016 p.Thr161Ile missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiB 3642020 c.486T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
rpoA 3877534 p.Val325Ala missense_variant 0.29 rifampicin
rpoA 3877542 c.966C>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877545 c.963G>C synonymous_variant 0.31 rifampicin
rpoA 3877548 c.960C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877557 c.951C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877566 p.Ser314Thr missense_variant 0.44 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.48 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.61 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.6 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.59 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.57 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.44 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.41 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.4 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.38 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.44 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877770 c.735_738delGTCAinsCAGC synonymous_variant 0.49 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.62 rifampicin
rpoA 3877842 c.666A>G synonymous_variant 0.58 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877872 c.636C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.6 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.6 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.6 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.64 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.6 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.21 rifampicin
rpoA 3878073 c.435C>G synonymous_variant 0.26 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.4 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.5 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.52 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.56 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.58 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.61 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.67 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878235 c.273G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.5 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.52 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.53 rifampicin Uncertain significance
rpoA 3878358 c.150C>G synonymous_variant 0.29 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.27 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878842 c.-335G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.47 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.51 rifampicin Uncertain significance
rpoA 3878886 c.-379G>A upstream_gene_variant 0.51 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.49 rifampicin
rpoA 3878893 c.-388_-386delCACinsAAG upstream_gene_variant 0.47 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.48 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.51 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.53 rifampicin
rpoA 3878929 c.-422G>C upstream_gene_variant 0.48 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.42 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3879040 c.-535_-533delGTGinsAAC upstream_gene_variant 0.24 rifampicin
rpoA 3879043 c.-536C>G upstream_gene_variant 0.25 rifampicin
rpoA 3879049 c.-542A>C upstream_gene_variant 0.25 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.35 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.47 rifampicin
rpoA 3879078 c.-571A>C upstream_gene_variant 0.48 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.44 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.5 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.57 rifampicin
rpoA 3879121 c.-616_-614delCTTinsACC upstream_gene_variant 0.51 rifampicin
rpoA 3879124 c.-618_-617delTGinsGC upstream_gene_variant 0.49 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.48 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.47 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.46 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.43 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.34 rifampicin
ddn 3986622 c.-222C>T upstream_gene_variant 0.26 pretomanid
delamanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.31 pretomanid
delamanid
clpC1 4038272 c.2433T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038290 p.Asp805Glu missense_variant 0.45 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038307 p.Val800Ile missense_variant 0.44 pyrazinamide
clpC1 4038310 p.Val799Leu missense_variant 0.45 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038325 p.Val794Ile missense_variant 0.43 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.47 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.35 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.49 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.5 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4038587 c.2118C>G synonymous_variant 0.58 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.57 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.49 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.52 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.45 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.44 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.53 pyrazinamide
clpC1 4038677 p.Pro676Ala missense_variant 0.53 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.62 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.62 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.66 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.68 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.68 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.67 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.68 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.62 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.63 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.55 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.71 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.71 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.69 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.72 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.75 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.82 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.82 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.83 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.83 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.83 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.8 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.62 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.57 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039088 c.1617G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039091 c.1614G>A synonymous_variant 0.56 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039119 c.1585_1586delTCinsAG synonymous_variant 0.56 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.64 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.64 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.72 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.72 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.78 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039220 c.1485G>T synonymous_variant 0.8 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.57 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.39 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.24 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039358 p.Ser449Ala missense_variant 0.31 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.45 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.45 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.48 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039436 c.1269G>A synonymous_variant 0.63 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.65 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.64 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.66 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.66 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039574 p.Ala377Ser missense_variant 0.58 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.71 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039652 p.Thr351Ser missense_variant 0.62 pyrazinamide
clpC1 4039688 c.1017G>A synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4039694 c.1011G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.66 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.64 pyrazinamide
clpC1 4039754 c.951G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039778 c.927A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.56 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.63 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.62 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.6 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.73 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.81 pyrazinamide
clpC1 4039919 c.786C>G synonymous_variant 0.79 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.77 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.76 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.74 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040018 c.687G>T synonymous_variant 0.7 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.68 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.72 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.72 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.64 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.64 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4040138 c.567G>C synonymous_variant 0.54 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.45 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.44 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.5 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.51 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040257 p.Ala150Ser missense_variant 0.52 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.46 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4040288 c.417C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040312 c.393G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040315 c.390G>A synonymous_variant 0.44 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040336 c.369G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040351 c.354C>T synonymous_variant 0.24 pyrazinamide
clpC1 4040360 c.345G>A synonymous_variant 0.25 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.26 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.5 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.6 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.52 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.55 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040644 c.61A>C synonymous_variant 0.38 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.37 pyrazinamide
clpC1 4040693 c.12A>T synonymous_variant 0.41 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.31 pyrazinamide
glpK 4138529 c.1227G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138532 c.1224G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138562 c.1194G>C synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138568 c.1188A>C synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138574 c.1182G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138577 p.Leu393Val missense_variant 0.52 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4138580 c.1176C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138596 p.Phe387Tyr missense_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138598 c.1158G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138625 c.1131G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138640 c.1116C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>T synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138655 c.1101G>T synonymous_variant 0.49 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138661 c.1095T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138667 c.1089G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138676 c.1080T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138681 p.Met359Val missense_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138682 c.1074C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.63 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>T synonymous_variant 0.65 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.7 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138745 c.1011G>C synonymous_variant 0.74 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.71 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138775 c.981C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138796 c.960A>G synonymous_variant 0.65 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138799 c.957T>G synonymous_variant 0.64 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138808 c.948G>T synonymous_variant 0.61 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138811 c.945C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138817 c.939T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138822 p.Asn312Asp missense_variant 0.61 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138829 c.927A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138838 c.918G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138847 c.909A>C synonymous_variant 0.59 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138853 c.903C>A synonymous_variant 0.56 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138859 p.Asn299Glu missense_variant 0.53 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138865 c.891A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138875 p.Thr294Lys missense_variant 0.45 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138877 c.879A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138880 c.876T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138889 c.867G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138898 c.858T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138910 c.846G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138913 c.843T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139526 p.Ala77Arg missense_variant 0.43 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139535 p.Val74Ala missense_variant 0.58 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139540 p.Ile72Met missense_variant 0.62 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.65 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 c.204G>A synonymous_variant 0.68 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139573 c.183C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139603 c.153C>G synonymous_variant 0.7 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139621 c.135G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139637 p.Ala40Gly missense_variant 0.57 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139639 c.117G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139648 c.108T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139653 p.His35Asp missense_variant 0.44 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139654 c.102C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139672 c.84C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139678 c.78C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4238963 c.-900C>T upstream_gene_variant 0.93 ethambutol Not assoc w R
embC 4240726 c.864G>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embC 4240735 c.873C>G synonymous_variant 0.44 ethambutol
embC 4240736 p.Ser292Ala missense_variant 0.44 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.57 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.58 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.6 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.56 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.55 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.56 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.56 ethambutol
embC 4240855 c.993G>C synonymous_variant 0.55 ethambutol
embC 4240865 p.Ala335Ser missense_variant 0.56 ethambutol
embC 4240879 c.1017G>A synonymous_variant 0.51 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.46 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.37 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.36 ethambutol
embC 4240906 c.1044C>G synonymous_variant 0.28 ethambutol
embC 4240910 p.Ala350Leu missense_variant 0.29 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.34 ethambutol
embC 4240922 p.Thr354Ala missense_variant 0.36 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.26 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.22 ethambutol
embC 4241008 c.1146G>C synonymous_variant 0.25 ethambutol
embC 4241011 c.1149C>G synonymous_variant 0.26 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.22 ethambutol
embC 4241020 c.1158G>C synonymous_variant 0.22 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.2 ethambutol
embC 4241024 p.Val388Phe missense_variant 0.24 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.32 ethambutol
embC 4241047 c.1185C>T synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4241050 c.1188T>G synonymous_variant 0.35 ethambutol
embC 4241059 c.1197G>A synonymous_variant 0.36 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.36 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.22 ethambutol
embC 4241109 p.Ala416Gly missense_variant 0.24 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.19 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.23 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.24 ethambutol
embC 4241593 c.1731C>G synonymous_variant 0.25 ethambutol
embC 4241595 p.Ala578Val missense_variant 0.24 ethambutol Uncertain significance
embC 4241611 c.1749G>C synonymous_variant 0.25 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.24 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247074 c.561G>C synonymous_variant 0.35 ethambutol
embB 4247095 c.582G>A synonymous_variant 0.33 ethambutol
embB 4247101 c.588G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247107 c.594C>G synonymous_variant 0.32 ethambutol
embB 4247111 p.Leu200Met missense_variant 0.3 ethambutol
embB 4247114 p.Ala201Ser missense_variant 0.3 ethambutol Uncertain significance
embB 4247117 p.Val202Phe missense_variant 0.29 ethambutol
embB 4247140 c.627G>C synonymous_variant 0.21 ethambutol
embB 4247144 p.Ser211Thr missense_variant 0.22 ethambutol
embB 4247378 p.Leu289Val missense_variant 0.21 ethambutol
embB 4247384 p.His291Tyr missense_variant 0.25 ethambutol
embB 4247398 c.885G>C synonymous_variant 0.42 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.44 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.56 ethambutol
embB 4247428 c.915C>G synonymous_variant 0.57 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embB 4247464 c.951C>G synonymous_variant 0.59 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.6 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.48 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.45 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.44 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.33 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.21 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248167 p.Thr552Pro missense_variant 0.27 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.31 ethambutol
embB 4248181 p.Ile556Met missense_variant 0.35 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.38 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.36 ethambutol
embB 4248203 p.Pro564Ala missense_variant 0.39 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.4 ethambutol Uncertain significance
embB 4248214 c.1701C>G synonymous_variant 0.46 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.5 ethambutol
embB 4248226 c.1713G>C synonymous_variant 0.5 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.54 ethambutol
embB 4248259 p.Met582Ile missense_variant 0.53 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.48 ethambutol
embB 4248290 p.Val593Ile missense_variant 0.42 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.47 ethambutol
embB 4248313 c.1800C>G synonymous_variant 0.41 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.38 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.36 ethambutol
embB 4248322 c.1809G>T synonymous_variant 0.36 ethambutol
embB 4249012 c.2499G>A synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269200 p.Ser212Arg missense_variant 0.22 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.22 ethambutol
aftB 4269204 c.-368G>C upstream_gene_variant 0.21 ethambutol
aftB 4269210 c.-374G>A upstream_gene_variant 0.24 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.26 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
aftB 4269240 c.-404G>C upstream_gene_variant 0.33 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.33 ethambutol
aftB 4269249 c.-413G>A upstream_gene_variant 0.35 ethambutol
aftB 4269252 c.-416C>A upstream_gene_variant 0.39 ethambutol
aftB 4269264 c.-428C>T upstream_gene_variant 0.56 ethambutol
ubiA 4269271 p.Val188Ala missense_variant 0.59 ethambutol Uncertain significance
aftB 4269291 c.-455A>G upstream_gene_variant 0.51 ethambutol
ubiA 4269299 p.Ile179Val missense_variant 0.49 ethambutol Uncertain significance
aftB 4269300 c.-464G>C upstream_gene_variant 0.48 ethambutol
aftB 4269305 c.-469T>C upstream_gene_variant 0.45 ethambutol
aftB 4269306 c.-470T>C upstream_gene_variant 0.45 ethambutol
ubiA 4269314 p.Lys174Gln missense_variant 0.44 ethambutol
ubiA 4269315 c.519C>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
ubiA 4269327 p.Lys169Asp missense_variant 0.4 ethambutol
ubiA 4269332 p.Thr168Ala missense_variant 0.37 ethambutol
ubiA 4269339 c.495C>T synonymous_variant 0.39 ethambutol Not assoc w R - Interim
aftB 4269342 c.-506G>T upstream_gene_variant 0.39 ethambutol
aftB 4269354 c.-518C>G upstream_gene_variant 0.36 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 0.41 ethambutol Not assoc w R
ubiA 4269392 p.Val148Leu missense_variant 0.46 ethambutol
aftB 4269405 c.-569G>A upstream_gene_variant 0.49 ethambutol
aftB 4269408 c.-572C>G upstream_gene_variant 0.49 ethambutol
aftB 4269414 c.-578T>C upstream_gene_variant 0.46 ethambutol
aftB 4269420 c.-584T>C upstream_gene_variant 0.43 ethambutol
aftB 4269428 c.-592T>C upstream_gene_variant 0.43 ethambutol
ubiA 4269432 p.Met134Ile missense_variant 0.43 ethambutol
aftB 4269435 c.-599C>G upstream_gene_variant 0.43 ethambutol
ubiA 4269440 p.Leu132Ile missense_variant 0.4 ethambutol
ubiA 4269446 p.Val130Ile missense_variant 0.38 ethambutol Uncertain significance
ubiA 4269447 p.Val129Ala missense_variant 0.38 ethambutol
aftB 4269453 c.-617A>G upstream_gene_variant 0.37 ethambutol
ubiA 4269474 c.360G>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
ubiA 4269479 p.Met119Leu missense_variant 0.23 ethambutol
ethA 4328462 c.-989C>T upstream_gene_variant 0.18 ethionamide
ethA 4328471 c.-998A>G upstream_gene_variant 0.2 ethionamide
ethA 4328473 c.-1000G>C upstream_gene_variant 0.2 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin