TB-Profiler result

Run: ERR323056
Summary

Run ID: ERR323056

Sample name:

Date: 2024-03-26T22:36:28.793076

Number of reads: 1586241

Percentage reads mapped: 29.2

Median coverage: 33.0

Strain: lineage4.4.1.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1.2 Euro-American None 0.9
lineage4.4.1 Euro-American (S-type) None 0.99
lineage4 Euro-American None 1.0
La1.7.1 M.bovis None 0.09
lineage4.4 Euro-American None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.820_822delTTAinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1018_1020delGGCinsCT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2077_2079delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiB c.436_438delGTGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.49 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303750 c.820_822delTTAinsAG frameshift_variant&missense_variant 0.3 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303948 c.1018_1020delGGCinsCT frameshift_variant&missense_variant 0.26 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.26 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305007 c.2077_2079delATCinsGG frameshift_variant&missense_variant 0.4 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155693 p.Ser140Asn missense_variant 0.48 isoniazid Uncertain significance Mutation from literature
fbiB 3641970 c.436_438delGTGinsAC frameshift_variant&missense_variant 0.28 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.56 isoniazid Not assoc w R - Interim
dnaA 748 c.748_750delCTCinsTG frameshift_variant&missense_variant 0.53 isoniazid Uncertain significance
dnaA 756 c.756T>C synonymous_variant 0.59 isoniazid
dnaA 766 c.766_767insCA frameshift_variant 0.62 isoniazid Uncertain significance
dnaA 769 c.770_771delCA frameshift_variant 0.62 isoniazid Uncertain significance
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.7 isoniazid Uncertain significance
dnaA 801 c.801G>A synonymous_variant 0.75 isoniazid
dnaA 805 c.805T>C synonymous_variant 0.77 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.76 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.7 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.65 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.66 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.67 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.66 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.68 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.7 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.59 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.59 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.62 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.58 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.41 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.38 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.38 isoniazid
dnaA 939 c.939C>G synonymous_variant 0.4 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.42 isoniazid
dnaA 948 c.948C>T synonymous_variant 0.39 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.57 isoniazid
dnaA 1071 c.1071C>G synonymous_variant 0.6 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.67 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.73 isoniazid
dnaA 1110 c.1110T>G synonymous_variant 0.75 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.8 isoniazid
dnaA 1122 c.1122C>T synonymous_variant 0.82 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.76 isoniazid
dnaA 1149 c.1149C>G synonymous_variant 0.64 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.62 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.64 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.61 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.55 isoniazid Not assoc w R - Interim
gyrB 6100 c.861G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 6196 c.957C>A synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrB 6204 p.Ser322Thr missense_variant 0.79 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.82 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrB 6324 c.1085_1086insGTCG frameshift_variant 0.52 levofloxacin Uncertain significance
moxifloxacin
gyrB 6327 c.1090_1093delGAAC frameshift_variant 0.52 levofloxacin Uncertain significance
moxifloxacin
gyrA 6346 c.-956C>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6565 c.-737G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6589 c.-713G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6590 p.Arg451Thr missense_variant 0.31 levofloxacin
moxifloxacin
gyrB 6597 p.Ser453Cys missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>T upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554_1555delTAinsCCTG frameshift_variant&missense_variant 0.61 levofloxacin Uncertain significance
moxifloxacin
gyrB 6796 c.1558_1559delGG frameshift_variant 0.61 levofloxacin Uncertain significance
moxifloxacin
gyrB 6808 c.1569C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.6 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6896 p.Arg553Lys missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6926 c.1687_1689delTTGinsCC frameshift_variant&missense_variant 0.34 levofloxacin Uncertain significance
moxifloxacin
gyrA 6931 c.-371A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7015 c.-287G>A upstream_gene_variant 0.81 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>T upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.81 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 7100 c.1861T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7120 c.-182T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7343 c.42G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7460 c.159C>T synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7520 c.219G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7601 c.300C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7703 c.402G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.59 levofloxacin
moxifloxacin
gyrA 7748 c.447A>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7820 c.519G>A synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>T synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7868 p.Ile189Met missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8126 c.825G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8156 c.855T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8282 c.981G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8306 c.1005C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8799 p.Ala500Pro missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8813 p.Asp504Glu missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8822 c.1521C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8840 c.1539C>T synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.61 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.49 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9077 c.1776C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9254 c.1953C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9266 p.Asp655Glu missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9284 c.1983T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9329 c.2028C>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9332 p.Asn677Lys missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCC frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9369 c.2068C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.2 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.22 isoniazid
fgd1 491487 c.705C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491491 p.Pro237Thr missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491520 c.738C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491536 c.754C>T synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491574 c.792C>T synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
mshA 575597 c.250_252delATCinsGG frameshift_variant&missense_variant 0.33 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575620 c.273G>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575627 p.Ala94Thr missense_variant 0.37 ethionamide
isoniazid
mshA 575635 c.288A>G synonymous_variant 0.32 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.25 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575683 c.336G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575686 c.339G>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575692 c.345G>A synonymous_variant 0.31 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.26 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.21 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575804 c.457_459delTCGinsAGC synonymous_variant 0.45 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.53 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575863 c.516G>A synonymous_variant 0.49 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.49 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.2 ethionamide
isoniazid
ccsA 620379 c.489G>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.47 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620430 c.540C>T synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.45 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620439 c.549T>G synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620463 c.573C>G synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620605 c.715_717delGTTinsAC frameshift_variant&missense_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>T synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.63 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>C synonymous_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>C synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620760 c.870C>T synonymous_variant 0.41 capreomycin
amikacin
kanamycin
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.34 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.38 ethionamide
Rv0565c 657653 c.-183C>T upstream_gene_variant 0.38 ethionamide
Rv0565c 657670 c.-200A>G upstream_gene_variant 0.41 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.41 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.47 ethionamide
Rv0565c 657703 c.-233C>A upstream_gene_variant 0.47 ethionamide
hadA 731726 c.-204C>A upstream_gene_variant 0.32 isoniazid
hadA 731732 c.-198G>T upstream_gene_variant 0.37 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.53 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.51 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.54 isoniazid
hadA 731798 c.-132C>T upstream_gene_variant 0.49 isoniazid
hadA 731801 c.-129C>T upstream_gene_variant 0.47 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.49 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.4 isoniazid
hadA 731822 c.-108G>A upstream_gene_variant 0.37 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.42 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.48 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.51 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
nusG 734496 c.243G>A synonymous_variant 0.65 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.65 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.69 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.7 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.67 rifampicin
nusG 734574 c.321C>T synonymous_variant 0.66 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
nusG 734595 p.Asp114Glu missense_variant 0.58 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.53 rifampicin
nusG 734600 p.Thr116Asn missense_variant 0.56 rifampicin Uncertain significance
nusG 734607 p.Asp118Glu missense_variant 0.55 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.55 rifampicin
nusG 734615 p.Ala121Gly missense_variant 0.5 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.44 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.39 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.35 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.45 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.52 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.52 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.49 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.49 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.47 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.53 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.53 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.49 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.47 rifampicin
nusG 734922 c.669C>T synonymous_variant 0.3 rifampicin
nusG 734925 c.672C>T synonymous_variant 0.27 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.26 rifampicin
nusG 734934 c.681G>C synonymous_variant 0.23 rifampicin
nusG 734937 c.684G>C synonymous_variant 0.24 rifampicin
nusG 734949 c.696T>C synonymous_variant 0.19 rifampicin
nusG 734950 p.Gly233Ser missense_variant 0.2 rifampicin
rpoB 760046 c.240G>C synonymous_variant 0.39 rifampicin
rpoB 760058 c.252C>G synonymous_variant 0.48 rifampicin
rpoB 760059 p.Tyr85Thr missense_variant 0.5 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.56 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.58 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.78 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.79 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760127 c.321C>T synonymous_variant 0.77 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.77 rifampicin Uncertain significance
rpoB 760142 c.336C>G synonymous_variant 0.72 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.74 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760304 c.498G>A synonymous_variant 0.75 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.76 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.75 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.76 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.74 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.73 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.79 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.74 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.73 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.73 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.75 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>C synonymous_variant 0.72 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.71 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.7 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.62 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760551 c.745_746delTCinsAG synonymous_variant 0.53 rifampicin
rpoB 760563 c.757delCinsAT frameshift_variant&synonymous_variant 0.33 rifampicin
rpoB 760566 p.Ser254Ala missense_variant 0.34 rifampicin
rpoB 760567 c.762delG frameshift_variant 0.33 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.45 rifampicin
rpoB 760595 c.789C>G synonymous_variant 0.47 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.52 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.77 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.68 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.71 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.49 rifampicin
rpoB 761300 c.1494G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.52 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.52 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.47 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 0.47 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.46 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.33 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761516 c.1710G>C synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.62 rifampicin
rpoB 761657 c.1851C>A synonymous_variant 0.59 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.51 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.49 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.38 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.25 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.7 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.71 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.7 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.72 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.74 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.75 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.73 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.72 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.63 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.67 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.69 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.67 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.65 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.65 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.64 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.64 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.65 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.68 rifampicin
rpoC 762390 c.-980C>T upstream_gene_variant 0.68 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.67 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.67 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.65 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.63 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.6 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.54 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.55 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762527 c.-843G>C upstream_gene_variant 0.51 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.48 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.49 rifampicin
rpoB 762537 c.2731_2733delTTGinsCC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 762560 c.-810A>T upstream_gene_variant 0.47 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.44 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.44 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.61 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.75 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.75 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.73 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.77 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.78 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.76 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.75 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763200 c.3394_3396delCTAinsTG frameshift_variant&stop_gained 0.6 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.58 rifampicin
rpoC 763217 c.-153G>C upstream_gene_variant 0.59 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.57 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.57 rifampicin
rpoC 763232 c.-138C>T upstream_gene_variant 0.54 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.53 rifampicin
rpoB 763241 p.Glu1145Asp missense_variant 0.54 rifampicin
rpoC 763259 c.-111G>T upstream_gene_variant 0.41 rifampicin
rpoB 763265 c.3459G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763373 c.4_6delCTCinsTA frameshift_variant&missense_variant 0.53 rifampicin
rpoC 763411 c.42T>C synonymous_variant 0.64 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.64 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.67 rifampicin
rpoC 763435 c.66A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763498 c.129G>A synonymous_variant 0.72 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.67 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.5 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.49 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.58 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.68 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.66 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>T synonymous_variant 0.51 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.51 rifampicin
rpoC 763781 p.Ser138Asp missense_variant 0.45 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.48 rifampicin
rpoC 763787 p.Asp140Asn missense_variant 0.49 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.52 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763831 c.462A>G synonymous_variant 0.44 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.33 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.3 rifampicin
rpoC 763844 p.Arg159Lys missense_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.37 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.37 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.35 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.37 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.37 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.37 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.3 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763903 c.534G>A synonymous_variant 0.27 rifampicin
rpoC 763921 c.552G>C synonymous_variant 0.29 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.4 rifampicin
rpoC 763940 p.Ala191Ser missense_variant 0.35 rifampicin Uncertain significance
rpoC 763947 p.Ala193Val missense_variant 0.38 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.41 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.42 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.4 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.36 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.38 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.44 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.44 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.46 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.46 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764153 p.Gln262Lys missense_variant 0.41 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.37 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764227 c.858G>T synonymous_variant 0.29 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.29 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.31 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.32 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.31 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.32 rifampicin
rpoC 764278 c.909_912delACAGinsGACCAA frameshift_variant&missense_variant 0.29 rifampicin
rpoC 764283 c.916_917delGG frameshift_variant 0.29 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.53 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.52 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.61 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.61 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.57 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.59 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.56 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.43 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.42 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.44 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.43 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.58 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.57 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.56 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.71 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.82 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.71 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.74 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.75 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.77 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.78 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.74 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.73 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.73 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.64 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>C synonymous_variant 0.49 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.53 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.53 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765376 c.2007C>T synonymous_variant 0.23 rifampicin
rpoC 765379 c.2010G>C synonymous_variant 0.22 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.21 rifampicin Uncertain significance
rpoC 765394 c.2025G>A synonymous_variant 0.23 rifampicin
rpoC 765403 c.2034_2035insAT frameshift_variant 0.24 rifampicin
rpoC 765406 c.2037G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765407 c.2039_2040delGT frameshift_variant 0.25 rifampicin
rpoC 765419 p.Val684Ile missense_variant 0.41 rifampicin Uncertain significance
rpoC 765425 p.Lys686Glu missense_variant 0.42 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.49 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.47 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.49 rifampicin Uncertain significance
rpoC 765493 c.2124G>C synonymous_variant 0.52 rifampicin
rpoC 765496 c.2127C>G synonymous_variant 0.54 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 0.42 rifampicin Uncertain significance
rpoC 765547 c.2178C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.33 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.36 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.36 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.35 rifampicin
rpoC 765591 p.Arg741Gln missense_variant 0.3 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.28 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.26 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.25 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.35 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.41 rifampicin
rpoC 765820 c.2451G>C synonymous_variant 0.43 rifampicin
rpoC 765823 c.2454C>G synonymous_variant 0.43 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.62 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.63 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.66 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.46 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.45 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.35 rifampicin
rpoC 766012 c.2643C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.34 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.36 rifampicin
rpoC 766061 p.Val898Asn missense_variant 0.32 rifampicin
rpoC 766067 p.Glu900Thr missense_variant 0.32 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.26 rifampicin
rpoC 766095 p.Thr909Ser missense_variant 0.2 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.23 rifampicin
rpoC 766299 p.Thr977Met missense_variant 0.21 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.38 rifampicin
rpoC 766336 c.2967C>G synonymous_variant 0.47 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.45 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766354 c.2985C>G synonymous_variant 0.44 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.52 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.56 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.57 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.54 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.54 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.53 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.62 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.64 rifampicin
rpoC 766480 c.3111C>T synonymous_variant 0.59 rifampicin
rpoC 766483 c.3114G>T synonymous_variant 0.55 rifampicin
rpoC 766486 c.3117A>C synonymous_variant 0.58 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.56 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.54 rifampicin
rpoC 766513 c.3144C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766516 c.3147C>G synonymous_variant 0.51 rifampicin
rpoC 766517 p.Thr1050Ser missense_variant 0.52 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.51 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.51 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.58 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.56 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.59 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.56 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.65 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.64 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.62 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.61 rifampicin
rpoC 766634 p.Phe1089Ile missense_variant 0.61 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.55 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.5 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.47 rifampicin
rpoC 766658 c.3289_3291delCGGinsGC frameshift_variant&missense_variant 0.47 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.46 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.37 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.33 rifampicin
rpoC 766694 c.3325_3327delCAGinsGT frameshift_variant&missense_variant 0.33 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.47 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766720 c.3351C>T synonymous_variant 0.56 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.61 rifampicin
rpoC 766732 c.3363G>C synonymous_variant 0.62 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.62 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.65 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.64 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.64 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.68 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.68 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.26 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.71 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.66 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.66 rifampicin
rpoC 767197 c.3828G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>T synonymous_variant 0.64 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767254 c.3885G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.44 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.3 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.28 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775946 c.2535C>G synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.35 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.41 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.41 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775996 p.Ile829Val missense_variant 0.28 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775997 c.2484T>C synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.22 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776009 c.2472A>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 776015 c.2464_2466delATCinsCG frameshift_variant&missense_variant 0.25 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776048 c.2433G>A synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 776053 c.2428T>C synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 776056 p.Val809Leu missense_variant 0.36 clofazimine
bedaquiline
mmpL5 776060 c.2421C>A synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 776063 c.2418C>G synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 776078 c.2403C>G synonymous_variant 0.39 clofazimine
bedaquiline
mmpL5 776087 c.2392_2394delGTCinsAG frameshift_variant&missense_variant 0.42 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776090 c.2391C>T synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 0.43 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776654 c.1827A>C synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 776681 c.1800G>C synonymous_variant 0.49 clofazimine
bedaquiline
mmpL5 776682 c.1798_1799insGA frameshift_variant 0.44 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776686 c.1793_1794delGG frameshift_variant 0.38 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776704 p.Asp593Asn missense_variant 0.46 clofazimine
bedaquiline
mmpL5 776715 p.Lys589Pro missense_variant 0.44 clofazimine
bedaquiline
mmpL5 776729 c.1752C>T synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 776733 p.Ser583Asn missense_variant 0.4 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776741 c.1740C>G synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 777094 c.1387T>C synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 777095 c.1386T>C synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 777101 c.1380C>G synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777104 c.1377G>C synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777107 c.1374T>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777110 c.1371T>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777115 p.Met456Leu missense_variant 0.24 clofazimine
bedaquiline
mmpL5 777116 c.1365C>T synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777126 p.Ser452Thr missense_variant 0.24 clofazimine
bedaquiline
mmpL5 777128 c.1353A>G synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 777142 p.Val447Leu missense_variant 0.31 clofazimine
bedaquiline
mmpL5 777154 p.Met443Leu missense_variant 0.41 clofazimine
bedaquiline
mmpL5 777161 c.1318_1320delCAGinsAC frameshift_variant&missense_variant 0.39 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777170 c.1311T>C synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 777173 c.1308C>G synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.39 clofazimine
bedaquiline
mmpL5 777188 c.1293T>C synonymous_variant 0.43 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 777209 c.1272C>T synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 777578 c.903C>G synonymous_variant 0.22 clofazimine
bedaquiline
mmpS5 778510 c.394_396delGATinsAC frameshift_variant&synonymous_variant 0.22 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 778522 c.-42A>C upstream_gene_variant 0.34 clofazimine
bedaquiline
mmpL5 778530 c.-50C>A upstream_gene_variant 0.32 clofazimine
bedaquiline
mmpL5 778537 c.-57G>A upstream_gene_variant 0.34 clofazimine
bedaquiline
mmpL5 778540 c.-60G>C upstream_gene_variant 0.35 clofazimine
bedaquiline
mmpL5 778543 c.-63A>G upstream_gene_variant 0.34 clofazimine
bedaquiline
mmpS5 778547 p.Gly120Asp missense_variant 0.35 clofazimine
bedaquiline
mmpS5 778556 p.Thr117Ile missense_variant 0.34 clofazimine
bedaquiline
mmpL5 778561 c.-81A>G upstream_gene_variant 0.38 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781559 c.-1G>C upstream_gene_variant 0.52 streptomycin
rpsL 781572 c.13_15delCAGinsAC frameshift_variant&missense_variant 0.55 streptomycin Uncertain significance
rpsL 781595 c.36T>C synonymous_variant 0.71 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.72 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.74 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.77 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.77 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.79 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.8 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.78 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.8 streptomycin
rpsL 781676 c.117C>G synonymous_variant 0.83 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.83 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.77 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.79 streptomycin
rpsL 781718 c.159C>A synonymous_variant 0.77 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.76 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.75 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.74 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.75 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.75 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.72 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.73 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.73 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.73 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.72 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.72 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.72 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.71 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.7 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.73 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.64 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.61 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.61 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.65 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.65 streptomycin
rpsL 781895 c.336G>A synonymous_variant 0.63 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.63 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.66 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.66 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.67 streptomycin Uncertain significance
rplC 800603 c.-206G>C upstream_gene_variant 0.23 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.38 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.46 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.56 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.6 linezolid
rplC 800690 c.-119C>G upstream_gene_variant 0.72 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.72 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.73 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.72 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.7 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.67 linezolid
rplC 800780 c.-29C>G upstream_gene_variant 0.46 linezolid
rplC 801387 c.579G>C synonymous_variant 0.28 linezolid
rplC 801396 c.588T>C synonymous_variant 0.29 linezolid
rplC 801399 c.591G>C synonymous_variant 0.3 linezolid
rplC 801400 c.592_594delGTTinsAC frameshift_variant&missense_variant 0.29 linezolid
rplC 801405 c.597T>G synonymous_variant 0.29 linezolid
rplC 801408 c.600C>A synonymous_variant 0.3 linezolid
rplC 801413 p.Thr202Asn missense_variant 0.3 linezolid
rplC 801426 c.618C>G synonymous_variant 0.27 linezolid
rplC 801438 c.630T>C synonymous_variant 0.28 linezolid
rplC 801441 c.633G>A synonymous_variant 0.28 linezolid
rplC 801447 c.639A>G synonymous_variant 0.28 linezolid
rplC 801453 c.645T>C synonymous_variant 0.27 linezolid
fbiC 1303500 c.570C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1303548 c.618G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>A synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303689 c.759T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303722 c.792C>T synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Thr missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303746 p.Asp272Glu missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303915 p.Met329Leu missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303938 c.1008C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303953 c.1023C>T synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303956 c.1026A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.55 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304763 c.1833C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304766 c.1836C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>A synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305006 p.Glu692Asp missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305043 c.2113_2115delTCAinsAGT synonymous_variant 0.35 clofazimine
pretomanid
delamanid
sigE 1364667 c.255T>C synonymous_variant 0.35 pyrazinamide
sigE 1364676 c.264C>G synonymous_variant 0.35 pyrazinamide
sigE 1364682 c.270G>A synonymous_variant 0.34 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.35 pyrazinamide
sigE 1364694 c.282G>C synonymous_variant 0.36 pyrazinamide
sigE 1364697 c.285G>C synonymous_variant 0.31 pyrazinamide
sigE 1364703 c.291G>C synonymous_variant 0.31 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.33 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.33 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.41 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.52 pyrazinamide
sigE 1364751 c.339C>T synonymous_variant 0.51 pyrazinamide
sigE 1364760 c.348C>G synonymous_variant 0.41 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.35 pyrazinamide
sigE 1364767 c.355_357delAGGinsCC frameshift_variant&missense_variant 0.34 pyrazinamide Uncertain significance
sigE 1364772 c.360G>C synonymous_variant 0.34 pyrazinamide
sigE 1364778 c.366G>T synonymous_variant 0.34 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.32 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.29 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.32 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.32 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.36 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.39 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.41 pyrazinamide
sigE 1364859 c.447C>G synonymous_variant 0.45 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.47 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.46 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.47 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.63 pyrazinamide Uncertain significance
sigE 1364919 c.507T>C synonymous_variant 0.43 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.4 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.4 pyrazinamide
sigE 1364931 c.519C>G synonymous_variant 0.37 pyrazinamide
sigE 1364942 p.Tyr177Phe missense_variant 0.31 pyrazinamide
sigE 1364950 c.538_540delGCAinsTC frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
atpE 1461042 c.-2delA upstream_gene_variant 0.33 bedaquiline
atpE 1461050 c.6C>T synonymous_variant 0.36 bedaquiline
atpE 1461056 c.12T>A synonymous_variant 0.45 bedaquiline
atpE 1461065 c.21C>T synonymous_variant 0.53 bedaquiline
atpE 1461071 c.27C>T synonymous_variant 0.58 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.61 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.64 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.66 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.59 bedaquiline
atpE 1461152 c.108C>T synonymous_variant 0.59 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.59 bedaquiline Uncertain significance
atpE 1461167 c.123G>C synonymous_variant 0.51 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.49 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.41 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.38 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.39 bedaquiline
atpE 1461188 c.144G>C synonymous_variant 0.39 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.38 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.23 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.23 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.23 bedaquiline
rrs 1471514 n.-332A>G upstream_gene_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471517 n.-329T>C upstream_gene_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601_604delTCTC non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606_607insCGGG non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>A non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473833 n.176G>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_632delTCCinsCTCG non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474293 n.637_647delCCTCTCCGGAG non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474306 n.649A>C non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052_1053insACAAG non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474711 n.1055_1058delGTGT non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475232 n.1575A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475286 n.1629T>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475382 n.1725A>C non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1972_1973insC non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476746 n.3089T>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476755 n.3098G>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476757 n.3100T>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
inhA 1673679 c.-523T>C upstream_gene_variant 0.38 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.41 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.44 ethionamide
isoniazid
fabG1 1673728 c.289_291delCTCinsTG frameshift_variant&missense_variant 0.53 ethionamide
isoniazid
fabG1 1673748 p.Glu103Asp missense_variant 0.52 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.52 ethionamide
isoniazid
inhA 1673757 c.-445G>A upstream_gene_variant 0.49 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.47 ethionamide
isoniazid
inhA 1673799 c.-403T>C upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673805 c.-397G>C upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673901 c.-301A>C upstream_gene_variant 0.3 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.3 ethionamide
isoniazid
inhA 1673916 c.-286A>T upstream_gene_variant 0.3 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.3 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1673925 c.-277C>T upstream_gene_variant 0.31 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673931 c.-271C>G upstream_gene_variant 0.36 ethionamide
isoniazid
fabG1 1673941 c.502_504delGCCinsTG frameshift_variant&missense_variant 0.41 ethionamide
isoniazid
inhA 1673946 c.-256C>T upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.41 ethionamide
isoniazid
inhA 1673967 c.-235G>C upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673973 c.-229G>C upstream_gene_variant 0.24 ethionamide
isoniazid Uncertain significance
fabG1 1674006 p.Asp189Glu missense_variant 0.27 ethionamide
isoniazid
inhA 1674015 c.-187C>T upstream_gene_variant 0.27 ethionamide
isoniazid Uncertain significance
inhA 1674096 c.-106G>C upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1674098 p.Val220Ala missense_variant 0.32 ethionamide
isoniazid
inhA 1674102 c.-100C>G upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1674114 c.-88T>A upstream_gene_variant 0.35 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674120 c.-82G>A upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1674123 c.-79T>C upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1674126 c.-76G>C upstream_gene_variant 0.34 ethionamide
isoniazid
fabG1 1674127 p.Ser230Gly missense_variant 0.34 ethionamide
isoniazid
inhA 1674132 c.-70T>C upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1674136 p.Ser233Ala missense_variant 0.35 ethionamide
isoniazid
inhA 1674171 c.-31T>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1674428 p.Gly76Asp missense_variant 0.27 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674435 c.234G>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674443 p.Ala81Val missense_variant 0.41 ethionamide
isoniazid
inhA 1674450 c.249G>C synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.44 ethionamide
isoniazid
inhA 1674462 c.261G>A synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674471 c.270G>T synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674474 c.273G>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674513 c.312C>T synonymous_variant 0.71 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.66 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674537 c.336C>G synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.67 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.7 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.57 ethionamide
isoniazid
inhA 1674585 c.384T>G synonymous_variant 0.56 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.59 ethionamide
isoniazid
inhA 1674618 c.417C>T synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.49 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.32 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674663 c.462G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674702 c.501G>A synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674703 c.502_504delTTGinsCC frameshift_variant&missense_variant 0.41 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 0.45 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.48 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674765 c.564C>T synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674792 c.591G>C synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674813 c.612C>T synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674819 c.618G>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674825 c.624C>T synonymous_variant 0.55 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674828 p.Glu209Asp missense_variant 0.57 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.62 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674879 c.678T>A synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674883 p.Ile228Leu missense_variant 0.6 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.55 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674934 p.Leu245Val missense_variant 0.43 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.38 ethionamide
isoniazid
rpsA 1833537 c.-5_-1delACAATinsCCAC upstream_gene_variant 0.22 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.32 pyrazinamide
rpsA 1833554 p.Thr5Ser missense_variant 0.38 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.47 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.45 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.44 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.48 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.48 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.51 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.53 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.55 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.44 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.47 pyrazinamide
rpsA 1833694 c.153G>A synonymous_variant 0.49 pyrazinamide
rpsA 1833700 c.159C>A synonymous_variant 0.54 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.32 pyrazinamide
rpsA 1833739 c.198C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833770 c.229_231delAACinsCT frameshift_variant&missense_variant 0.39 pyrazinamide Uncertain significance
rpsA 1833778 c.237C>T synonymous_variant 0.41 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.43 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.46 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.61 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.62 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.7 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.76 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.76 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.8 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.77 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.79 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.73 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.77 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.77 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.41 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.49 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>A synonymous_variant 0.58 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834298 p.Gln253Thr missense_variant 0.63 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.63 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.72 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.74 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.74 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.72 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.69 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.68 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.65 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834556 p.Ala339Gln missense_variant 0.62 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.64 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.7 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.66 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.62 pyrazinamide
rpsA 1834678 c.1137C>T synonymous_variant 0.67 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834705 c.1164C>G synonymous_variant 0.63 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.45 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.27 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.56 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.54 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.52 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.52 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.49 linezolid
tsnR 1853390 c.-216G>T upstream_gene_variant 0.5 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.48 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.51 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.5 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.5 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.46 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.43 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.42 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.4 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.4 linezolid
tsnR 1853480 c.-126G>C upstream_gene_variant 0.41 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.41 linezolid
tsnR 1853490 c.-116_-114delCCGinsGC upstream_gene_variant 0.42 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.42 linezolid
tsnR 1853516 c.-90C>G upstream_gene_variant 0.29 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102218 c.825C>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102227 c.816C>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.23 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102242 c.801G>T synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102245 c.796_798delGTCinsCG frameshift_variant&missense_variant 0.21 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102248 p.Thr265Asn missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102259 p.Ser262Pro missense_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102269 c.774C>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102990 p.Val18Ala missense_variant 1.0 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R
katG 2155626 c.486G>C synonymous_variant 0.29 isoniazid
katG 2155632 c.480A>C synonymous_variant 0.39 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.44 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.43 isoniazid Uncertain significance
katG 2155655 p.Lys153Gln missense_variant 0.4 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.4 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.45 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.46 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.43 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.33 isoniazid
katG 2155752 c.360C>T synonymous_variant 0.23 isoniazid
katG 2155765 p.His116Phe missense_variant 0.27 isoniazid
PPE35 2167770 p.Ser948Ile missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169840 p.Gly258Asp missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170066 p.Ala183Thr missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.63 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.54 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.52 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.33 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.25 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.42 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.64 isoniazid
kasA 2518156 c.42T>C synonymous_variant 0.66 isoniazid
kasA 2518159 c.45G>C synonymous_variant 0.66 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.63 isoniazid
kasA 2518180 c.66G>C synonymous_variant 0.65 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.63 isoniazid
kasA 2518193 p.Pro27Ala missense_variant 0.62 isoniazid
kasA 2518219 c.105T>G synonymous_variant 0.67 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.64 isoniazid
kasA 2518245 p.His44Arg missense_variant 0.48 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.42 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.41 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.27 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.35 isoniazid
kasA 2519143 c.1029G>C synonymous_variant 0.26 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.37 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.37 isoniazid
kasA 2519180 c.1066_1068delGTGinsAC frameshift_variant&missense_variant 0.35 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.37 isoniazid
kasA 2519203 c.1089C>G synonymous_variant 0.36 isoniazid
kasA 2519206 c.1092C>T synonymous_variant 0.38 isoniazid
kasA 2519224 c.1110C>A synonymous_variant 0.36 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.32 isoniazid
Rv2477c 2782426 c.1617G>A synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782431 p.Glu538Gln missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>T synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782495 p.Asp516Ser missense_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.66 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782504 c.1539G>A synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783837 p.Thr69Ser missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783847 p.Thr66Pro missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783848 c.195C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 p.Lys56Thr missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783947 c.96C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859739 p.Ala227Ser missense_variant 0.21 clofazimine
bedaquiline
pepQ 2859744 c.675G>C synonymous_variant 0.2 clofazimine
bedaquiline
pepQ 2859747 c.672C>G synonymous_variant 0.21 clofazimine
bedaquiline
pepQ 2859750 c.669C>T synonymous_variant 0.19 clofazimine
bedaquiline
pepQ 2859774 c.645C>T synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2860213 p.Pro69Leu missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
ribD 2986868 c.30T>C synonymous_variant 0.97 para-aminosalicylic_acid
Rv2752c 3065026 p.Arg389Lys missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065031 c.1161G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065052 c.1140G>A synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065070 c.1122C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065154 c.1038G>A synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065186 c.1006T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065187 c.1003_1005delGTGinsAC frameshift_variant&missense_variant 0.31 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065193 c.999C>G synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065196 c.996T>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065202 c.990T>C synonymous_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065205 c.987T>C synonymous_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065210 c.982T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065223 c.969T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065229 c.963G>T synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065232 c.960T>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065241 c.951A>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065249 c.943T>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067754 c.192C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073950 c.522G>C synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3073971 c.501C>T synonymous_variant 0.61 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.61 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3073992 c.478_480delAGCinsTCG synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3073997 c.475C>T synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.55 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.43 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.36 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074087 p.Ile129Leu missense_variant 0.32 para-aminosalicylic_acid
thyA 3074089 p.Ile128Asn missense_variant 0.3 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.28 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625240 c.-330T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625251 c.-341C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625258 c.-348G>T upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625270 c.-360G>A upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625276 c.-366C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
lpqB 3625282 c.-372C>G upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625294 c.-384C>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3625324 p.His430Arg missense_variant 0.27 bedaquiline
rifampicin
mtrB 3625687 c.927G>A synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625690 c.-780T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625701 c.911_912delGC frameshift_variant 0.25 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625708 c.906delCinsTGT frameshift_variant&synonymous_variant 0.26 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625729 c.885A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625747 c.867G>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.33 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.24 bedaquiline