TB-Profiler result

Run: SRR8217918
Summary

Run ID: SRR8217918

Sample name:

Date: 2024-04-15T15:29:38.475859

Number of reads: 1214598

Percentage reads mapped: 32.65

Median coverage: 22.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.1.2 Indo-Oceanic RD239 0.08
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
lineage4.9 Euro-American (H37Rv-like) None 0.4
lineage2.2.1.1 East-Asian (Beijing) RD105;RD207;RD181;RD150 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ile335Thr Mutation from literature
p.Ile317Leu Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.196_198delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.202_204delCTGinsAT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.280_282delGGAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.394_396delCTGinsTA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.409_411delGGGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.729delTinsCAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1741_1742delGTinsACGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1748_1749delAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1825_1827delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1963_1965delGGCinsAT Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiA c.166_168delCTGinsGA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.337_339delCTGinsTA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 490978 c.196_198delAACinsGG frameshift_variant&missense_variant 0.65 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 490984 c.202_204delCTGinsAT frameshift_variant&missense_variant 0.7 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491062 c.280_282delGGAinsAC frameshift_variant&missense_variant 0.69 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.68 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491176 c.394_396delCTGinsTA frameshift_variant&stop_gained 0.84 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491191 c.409_411delGGGinsCC frameshift_variant&missense_variant 0.85 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.81 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303659 c.729delTinsCAC frameshift_variant&synonymous_variant 0.52 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304671 c.1741_1742delGTinsACGG frameshift_variant&missense_variant 0.58 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304674 c.1748_1749delAG frameshift_variant 0.6 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304755 c.1825_1827delCTAinsTG frameshift_variant&stop_gained 0.65 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304893 c.1963_1965delGGCinsAT frameshift_variant&missense_variant 0.42 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155108 p.Ile335Thr missense_variant 0.57 isoniazid Mutation from literature
katG 2155163 p.Ile317Leu missense_variant 0.35 isoniazid Mutation from literature
fbiA 3640708 c.166_168delCTGinsGA frameshift_variant&missense_variant 0.29 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiA 3640879 c.337_339delCTGinsTA frameshift_variant&stop_gained 0.38 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 579 c.579C>T synonymous_variant 0.64 isoniazid
dnaA 582 c.582A>T synonymous_variant 0.64 isoniazid
dnaA 585 c.585A>G synonymous_variant 0.62 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.69 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.71 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.72 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.72 isoniazid
dnaA 633 c.633T>A synonymous_variant 0.74 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.71 isoniazid
dnaA 651 c.651G>C synonymous_variant 0.69 isoniazid
dnaA 654 c.654A>G synonymous_variant 0.67 isoniazid
dnaA 657 c.657C>T synonymous_variant 0.67 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.68 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.64 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.6 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>A synonymous_variant 0.6 isoniazid
dnaA 682 c.682_684delTTGinsCC frameshift_variant&missense_variant 0.6 isoniazid Uncertain significance
dnaA 690 c.690G>C synonymous_variant 0.62 isoniazid
dnaA 693 c.693A>C synonymous_variant 0.62 isoniazid
dnaA 699 c.699G>C synonymous_variant 0.65 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.62 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.62 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.62 isoniazid
dnaA 723 c.723A>G synonymous_variant 0.62 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.65 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>A synonymous_variant 0.65 isoniazid
dnaA 750 c.750C>G synonymous_variant 0.67 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.74 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.74 isoniazid
dnaA 795 c.795A>G synonymous_variant 0.72 isoniazid
dnaA 801 c.801G>C synonymous_variant 0.72 isoniazid
dnaA 802 c.802C>T synonymous_variant 0.72 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.72 isoniazid Uncertain significance
dnaA 819 c.819C>T synonymous_variant 0.76 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.76 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.76 isoniazid
gyrB 6046 c.807C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6047 p.Ala270Ser missense_variant 0.56 levofloxacin
moxifloxacin
gyrB 6052 c.813T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6055 c.816T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6067 c.828G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrB 6073 c.834T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrB 6086 c.847_849delACCinsCG frameshift_variant&missense_variant 0.67 levofloxacin Uncertain significance
moxifloxacin
gyrB 6091 c.852G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrB 6100 c.861G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrB 6109 c.870G>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 6565 c.-737G>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6592 c.-710C>T upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.81 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.87 levofloxacin
moxifloxacin
gyrA 6628 c.-674C>G upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>A upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6646 c.-656C>T upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.89 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>C upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6685 c.-617C>G upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>T synonymous_variant 0.97 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6724 c.-578G>C upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrB 6727 c.1488G>A synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6730 c.-572A>G upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrA 6763 c.-539G>A upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>A synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6787 c.-515G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 6820 c.-482C>T upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>T upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>A upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>T upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>T upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7187 c.1948_1950delATCinsGT frameshift_variant&missense_variant 0.75 levofloxacin Uncertain significance
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7201 c.-101G>A upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrB 7210 p.Asp657Glu missense_variant 0.74 levofloxacin
moxifloxacin
gyrA 7216 c.-86G>T upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrB 7219 c.1980C>T synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7225 c.-77T>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7243 c.-59G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7415 c.114C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7442 c.141G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7796 c.495G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7817 c.516C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8126 c.825G>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8156 c.855T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8171 c.870G>A synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8186 c.885G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8199 p.Ser300Ala missense_variant 0.62 levofloxacin
moxifloxacin
gyrA 8204 c.903C>T synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8217 c.916_918delTCTinsAGC synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8231 c.930C>T synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8234 c.933T>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.71 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8318 c.1017C>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8351 c.1050C>T synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>T synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.68 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8400 p.Asp367Asn missense_variant 0.69 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8411 c.1110C>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8468 c.1167C>T synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8472 c.1171C>T synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8507 c.1206C>T synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8510 c.1209G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8513 c.1212C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8534 c.1233G>A synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8537 c.1236G>A synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8555 c.1254G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.62 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8580 p.Ile427Val missense_variant 0.71 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8597 c.1296C>G synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8633 c.1332C>T synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8637 c.1336C>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8706 c.1405C>T synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8723 c.1422G>A synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8730 c.1429_1431delGGGinsCC frameshift_variant&missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Lys missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.74 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.63 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8813 c.1512C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8846 c.1545C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8936 c.1635G>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.62 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>T synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Arg missense_variant 0.68 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>A synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.74 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9038 c.1737C>T synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9080 c.1779G>A synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9131 c.1830G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 9251 c.1950G>A synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 9254 c.1953C>G synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9263 c.1962C>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9266 c.1965C>T synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.68 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 9287 c.1986G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.69 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9368 c.2067G>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9383 c.2082T>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9392 c.2091C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9419 c.2118T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Ala missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 9429 p.Arg710Tyr missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 9437 c.2136G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9441 c.2140C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9449 c.2148C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9452 c.2151G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9455 c.2154T>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9464 c.2163C>A synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9482 c.2181G>A synonymous_variant 0.41 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 9485 c.2184A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9488 c.2187G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9494 c.2193T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9497 c.2196G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9500 c.2199A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9503 c.2202T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9518 c.2217A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9605 c.2304C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9608 c.2307C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9621 p.Leu774Val missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 9630 p.Val777Ile missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9647 c.2346C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9650 c.2349G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9659 c.2358C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9668 c.2367C>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9674 c.2373T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9677 c.2376C>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9683 c.2382G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9686 c.2385A>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9716 c.2415T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9717 c.2416C>T synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 9740 c.2439G>A synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9749 c.2448G>A synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9755 c.2454C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
fgd1 490809 c.27A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 490818 c.36C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490830 c.48A>G synonymous_variant 0.52 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490836 c.54C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.48 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490857 c.75C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490866 c.84A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490869 c.87C>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490875 c.93C>T synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490881 c.99C>T synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>A synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 490968 c.186C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 490971 c.189A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 490983 c.201G>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491001 c.219G>A synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491004 c.222G>A synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491038 p.Ile86Val missense_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>A synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491067 c.285C>T synonymous_variant 0.72 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491077 p.Asn99Gly missense_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>A synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491109 c.327G>A synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491113 c.331C>T synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491187 c.405G>A synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491206 c.424C>T synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fgd1 491223 c.441C>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.8 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.8 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491322 c.540G>T synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.85 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491364 c.582T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491379 c.597C>T synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491490 c.708C>T synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491523 c.741G>A synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fgd1 491556 c.774G>A synonymous_variant 0.86 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491583 c.801G>A synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491628 c.846G>A synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491685 c.903G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491688 c.906A>G synonymous_variant 0.72 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491697 c.915G>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491712 c.930T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491718 c.936A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491721 c.939A>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491724 c.942A>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491727 c.945T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574616 c.-732G>C upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574622 c.-726C>T upstream_gene_variant 0.52 ethionamide
isoniazid
mshA 574629 c.-719G>A upstream_gene_variant 0.53 ethionamide
isoniazid
mshA 574637 c.-711C>G upstream_gene_variant 0.58 ethionamide
isoniazid
mshA 574640 c.-708G>C upstream_gene_variant 0.58 ethionamide
isoniazid
mshA 574647 c.-701C>T upstream_gene_variant 0.62 ethionamide
isoniazid
mshA 574650 c.-698A>C upstream_gene_variant 0.62 ethionamide
isoniazid
mshA 574664 c.-684G>C upstream_gene_variant 0.62 ethionamide
isoniazid
mshA 574670 c.-678C>G upstream_gene_variant 0.64 ethionamide
isoniazid
mshA 574673 c.-675A>C upstream_gene_variant 0.66 ethionamide
isoniazid
mshA 574674 c.-674_-672delCCGinsGC upstream_gene_variant 0.66 ethionamide
isoniazid
mshA 574680 c.-668_-666delTCGinsAC upstream_gene_variant 0.64 ethionamide
isoniazid
mshA 574688 c.-660G>C upstream_gene_variant 0.64 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 574718 c.-630A>G upstream_gene_variant 0.64 ethionamide
isoniazid
mshA 574721 c.-627C>G upstream_gene_variant 0.64 ethionamide
isoniazid
mshA 574739 c.-609T>C upstream_gene_variant 0.62 ethionamide
isoniazid
mshA 574742 c.-606G>A upstream_gene_variant 0.65 ethionamide
isoniazid
mshA 574752 c.-596_-594delTGCinsAT upstream_gene_variant 0.5 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.55 ethionamide
isoniazid
mshA 575732 c.385_387delCTTinsTG frameshift_variant&missense_variant 0.66 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575737 c.390T>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.66 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.67 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.68 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.69 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.68 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.73 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.71 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.73 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.67 ethionamide
isoniazid
mshA 575872 c.525C>T synonymous_variant 0.69 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.65 ethionamide
isoniazid
mshA 575890 c.543C>T synonymous_variant 0.66 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.61 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.62 ethionamide
isoniazid
mshA 575903 p.Ala186Ser missense_variant 0.63 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.38 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575920 c.573C>T synonymous_variant 0.62 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575923 c.576C>T synonymous_variant 0.61 ethionamide
isoniazid
mshA 575925 p.Gly193Ala missense_variant 0.61 ethionamide
isoniazid
mshA 575935 c.588G>T synonymous_variant 0.59 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.6 ethionamide
isoniazid
mshA 575945 c.598_600delACGinsTT frameshift_variant&missense_variant 0.6 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575953 c.606G>C synonymous_variant 0.62 ethionamide
isoniazid
mshA 575965 c.618C>T synonymous_variant 0.61 ethionamide
isoniazid
mshA 575977 c.630G>C synonymous_variant 0.43 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.43 ethionamide
isoniazid
ccsA 619601 c.-290G>A upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257_-256delTCinsGT upstream_gene_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 619648 c.-243C>G upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619650 c.-241_-240delTCinsCG upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>C upstream_gene_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>G upstream_gene_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 619696 c.-195C>A upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 619697 c.-194A>C upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 619702 c.-189C>G upstream_gene_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 619708 c.-183G>C upstream_gene_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620169 c.279G>C synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620173 p.Val95Ile missense_variant 0.65 capreomycin
amikacin
kanamycin
ccsA 620184 c.294C>T synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620197 p.Gln103Ala missense_variant 0.71 capreomycin
amikacin
kanamycin
ccsA 620247 p.Leu119Phe missense_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.66 capreomycin
amikacin
kanamycin
ccsA 620253 c.363G>C synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620275 c.385C>T synonymous_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>A synonymous_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620298 c.408G>A synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620314 c.424C>T synonymous_variant 0.56 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620337 c.447C>G synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620338 c.448_450delACCinsGG frameshift_variant&missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620351 p.Arg154His missense_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620358 c.468C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 0.45 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>C synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>A synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620643 c.753C>T synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620676 c.786C>T synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620685 c.795G>A synonymous_variant 0.49 capreomycin Not assoc w R - Interim
amikacin
kanamycin Not assoc w R - Interim
ccsA 620692 p.Ser268Ala missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>C synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAG frameshift_variant&missense_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620781 c.891C>G synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620783 p.Ala298Val missense_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 620802 c.912C>G synonymous_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 620808 c.918T>C synonymous_variant 0.64 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620814 c.924C>T synonymous_variant 0.75 capreomycin
amikacin Not assoc w R - Interim
kanamycin
ccsA 620820 c.930T>C synonymous_variant 0.75 capreomycin
amikacin
kanamycin
ccsA 620823 c.933C>T synonymous_variant 0.75 capreomycin
amikacin
kanamycin
ccsA 620847 c.957G>C synonymous_variant 0.65 capreomycin
amikacin
kanamycin
ccsA 620853 c.963G>C synonymous_variant 0.53 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv0565c 656532 c.939C>A synonymous_variant 0.42 ethionamide
Rv0565c 656535 c.936C>A synonymous_variant 0.42 ethionamide
Rv0565c 656538 p.Ser311Glu missense_variant 0.4 ethionamide
Rv0565c 656542 p.Thr310Ser missense_variant 0.4 ethionamide
Rv0565c 656547 c.924C>G synonymous_variant 0.4 ethionamide
Rv0565c 656551 p.Asn307Val missense_variant 0.43 ethionamide
Rv0565c 656556 c.915G>C synonymous_variant 0.38 ethionamide Not assoc w R - Interim
Rv0565c 656568 c.903G>C synonymous_variant 0.4 ethionamide
Rv0565c 656571 c.900C>T synonymous_variant 0.42 ethionamide
Rv0565c 656577 c.894C>T synonymous_variant 0.42 ethionamide Not assoc w R - Interim
Rv0565c 656583 c.888A>G synonymous_variant 0.42 ethionamide
Rv0565c 656589 c.882T>C synonymous_variant 0.42 ethionamide
Rv0565c 656604 c.867G>C synonymous_variant 0.45 ethionamide
Rv0565c 656611 p.Thr287Lys missense_variant 0.45 ethionamide
Rv0565c 656922 p.Ile183Met missense_variant 0.36 ethionamide
Rv0565c 656943 c.528G>C synonymous_variant 0.36 ethionamide
Rv0565c 656946 c.525T>C synonymous_variant 0.38 ethionamide
Rv0565c 656952 c.519A>G synonymous_variant 0.38 ethionamide
Rv0565c 656964 c.507C>G synonymous_variant 0.4 ethionamide
Rv0565c 656973 c.498A>C synonymous_variant 0.44 ethionamide
Rv0565c 656976 c.493_495delGCGinsAC frameshift_variant&missense_variant 0.5 ethionamide Uncertain significance
Rv0565c 656985 c.486T>C synonymous_variant 0.53 ethionamide
Rv0565c 656990 p.Lys161Gln missense_variant 0.53 ethionamide
Rv0565c 656994 c.475_477delATCinsCT frameshift_variant&missense_variant 0.57 ethionamide Uncertain significance
Rv0565c 657000 p.Gly157Pro missense_variant 0.57 ethionamide
Rv0565c 657006 p.Asp155Glu missense_variant 0.57 ethionamide Uncertain significance
Rv0565c 657009 c.462C>G synonymous_variant 0.6 ethionamide
Rv0565c 657027 c.444T>C synonymous_variant 0.55 ethionamide
Rv0565c 657043 c.427_428delAGinsTC synonymous_variant 0.55 ethionamide
Rv0565c 657065 p.Ser136Gly missense_variant 0.5 ethionamide
Rv0565c 657073 p.His133Thr missense_variant 0.38 ethionamide
Rv0565c 657076 p.Lys132Thr missense_variant 0.4 ethionamide
Rv0565c 657078 p.His131Pro missense_variant 0.4 ethionamide
Rv0565c 657089 p.Asn128Asp missense_variant 0.38 ethionamide
Rv0565c 657097 p.Phe125Ala missense_variant 0.35 ethionamide
Rv0565c 657105 c.366C>G synonymous_variant 0.35 ethionamide
Rv0565c 657114 c.357T>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
Rv0565c 657123 c.348A>C synonymous_variant 0.33 ethionamide
Rv0565c 657135 c.336G>C synonymous_variant 0.3 ethionamide
Rv0565c 657138 c.331_333delGCAinsTG frameshift_variant&missense_variant 0.3 ethionamide Uncertain significance
Rv0565c 657142 p.Arg110His missense_variant 0.7 ethionamide Uncertain significance
Rv0565c 657144 c.327T>C synonymous_variant 0.32 ethionamide
Rv0565c 657147 c.324C>T synonymous_variant 0.32 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.59 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.62 ethionamide
Rv0565c 657336 p.Arg45Gln missense_variant 0.52 ethionamide Uncertain significance
Rv0565c 657340 p.Ala44Glu missense_variant 0.52 ethionamide
Rv0565c 657345 c.124_126delAGGinsCC frameshift_variant&missense_variant 0.5 ethionamide Uncertain significance
Rv0565c 657348 c.123A>G synonymous_variant 0.5 ethionamide
Rv0565c 657353 c.118C>T synonymous_variant 0.5 ethionamide
Rv0565c 657358 p.Thr38Val missense_variant 0.55 ethionamide
Rv0565c 657364 p.Thr36Ser missense_variant 0.55 ethionamide
Rv0565c 657369 c.100_102delCAGinsGT frameshift_variant&missense_variant 0.55 ethionamide Uncertain significance
Rv0565c 657385 p.Ile29Thr missense_variant 0.5 ethionamide
Rv0565c 657389 p.Ile28Leu missense_variant 0.48 ethionamide
Rv0565c 657408 c.63A>T synonymous_variant 0.5 ethionamide
Rv0565c 657414 c.57C>T synonymous_variant 0.48 ethionamide
Rv0565c 657417 c.54C>G synonymous_variant 0.43 ethionamide
Rv0565c 657572 c.-102A>G upstream_gene_variant 0.47 ethionamide
Rv0565c 657575 c.-105G>C upstream_gene_variant 0.47 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.53 ethionamide
Rv0565c 657581 c.-111G>C upstream_gene_variant 0.53 ethionamide
Rv0565c 657592 c.-122A>G upstream_gene_variant 0.59 ethionamide
Rv0565c 657593 c.-123G>A upstream_gene_variant 0.59 ethionamide
Rv0565c 657629 c.-159G>A upstream_gene_variant 0.65 ethionamide
Rv0565c 657640 c.-170A>T upstream_gene_variant 0.61 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.61 ethionamide
Rv0565c 657670 c.-200A>T upstream_gene_variant 0.7 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.7 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.74 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.8 ethionamide
Rv0565c 657732 c.-263_-262delAGinsTC upstream_gene_variant 0.73 ethionamide
hadA 731687 c.-243G>A upstream_gene_variant 0.66 isoniazid
hadA 731694 c.-236T>A upstream_gene_variant 0.59 isoniazid
hadA 731695 c.-235C>T upstream_gene_variant 0.56 isoniazid
hadA 731697 c.-233T>A upstream_gene_variant 0.56 isoniazid
hadA 731698 c.-232T>G upstream_gene_variant 0.59 isoniazid
hadA 731700 c.-230G>A upstream_gene_variant 0.58 isoniazid
hadA 731706 c.-224_-223insG upstream_gene_variant 0.61 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.61 isoniazid
hadA 731712 c.-218A>G upstream_gene_variant 0.61 isoniazid
hadA 731717 c.-213T>C upstream_gene_variant 0.67 isoniazid
hadA 731729 c.-201C>T upstream_gene_variant 0.66 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.66 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.69 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.54 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.5 isoniazid
hadA 731795 c.-135C>T upstream_gene_variant 0.47 isoniazid
hadA 731804 c.-126C>T upstream_gene_variant 0.42 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 0.39 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.39 isoniazid
hadA 731813 c.-117C>T upstream_gene_variant 0.39 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.4 isoniazid
hadA 731822 c.-108G>A upstream_gene_variant 0.4 isoniazid
nusG 734384 p.Ser44Thr missense_variant 0.5 rifampicin
nusG 734388 c.135G>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.57 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.65 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.63 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.72 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.74 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.74 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.75 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.79 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.86 rifampicin
nusG 734526 c.273G>A synonymous_variant 0.83 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.8 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.8 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.79 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>C synonymous_variant 0.78 rifampicin
nusG 734589 c.336G>C synonymous_variant 0.76 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.66 rifampicin
nusG 734614 p.Ala121Ser missense_variant 0.66 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.62 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.55 rifampicin
nusG 734637 c.384G>T synonymous_variant 0.57 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.64 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.62 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.6 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.62 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.65 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.62 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.61 rifampicin
nusG 734863 c.610_612delACGinsTC frameshift_variant&missense_variant 0.67 rifampicin
nusG 734889 c.636G>A synonymous_variant 0.71 rifampicin
nusG 734892 c.639G>A synonymous_variant 0.68 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.71 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.67 rifampicin
nusG 734922 c.669C>T synonymous_variant 0.67 rifampicin
nusG 734934 c.681G>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
nusG 734940 c.687G>A synonymous_variant 0.48 rifampicin
rpoB 759604 c.-203A>T upstream_gene_variant 0.62 rifampicin
rpoB 759606 c.-201T>C upstream_gene_variant 0.64 rifampicin
rpoB 759629 c.-178T>C upstream_gene_variant 0.73 rifampicin
rpoB 759643 c.-164T>C upstream_gene_variant 0.68 rifampicin
rpoB 759647 c.-160T>C upstream_gene_variant 0.65 rifampicin Uncertain significance
rpoB 759656 c.-151_-149delAGTinsG upstream_gene_variant 0.6 rifampicin
rpoB 759661 c.-146G>C upstream_gene_variant 0.6 rifampicin
rpoB 759672 c.-135G>A upstream_gene_variant 0.55 rifampicin
rpoB 759674 c.-133T>C upstream_gene_variant 0.55 rifampicin
rpoB 759678 c.-129T>C upstream_gene_variant 0.55 rifampicin
rpoB 759691 c.-116A>T upstream_gene_variant 0.57 rifampicin
rpoB 759693 c.-114C>T upstream_gene_variant 0.57 rifampicin
rpoB 759701 c.-106A>T upstream_gene_variant 0.55 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.37 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.5 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.59 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.58 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>G synonymous_variant 0.63 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.64 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.85 rifampicin
rpoB 760226 c.420G>A synonymous_variant 0.85 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.77 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.77 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.78 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.78 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.79 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.7 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.68 rifampicin
rpoB 760388 c.582C>T synonymous_variant 0.64 rifampicin
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.66 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>G synonymous_variant 0.71 rifampicin
rpoB 760478 c.672C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.7 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>G synonymous_variant 0.74 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.77 rifampicin
rpoB 760521 p.Ser239Ala missense_variant 0.78 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.78 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.88 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.86 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760622 c.816C>T synonymous_variant 0.78 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.74 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.72 rifampicin
rpoB 760671 c.865C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760796 c.990A>G synonymous_variant 0.37 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.58 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.67 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.7 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.77 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.79 rifampicin
rpoB 760916 c.1110C>G synonymous_variant 0.82 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.82 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.82 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.83 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.84 rifampicin
rpoB 761006 c.1200C>T synonymous_variant 0.85 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761066 c.1260G>C synonymous_variant 0.85 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.85 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.83 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.82 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.72 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761217 c.1411_1413delCCGinsTC frameshift_variant&missense_variant 0.68 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.68 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761252 c.1446C>G synonymous_variant 0.69 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>T synonymous_variant 0.52 rifampicin
rpoB 761346 p.Val514Arg missense_variant 0.5 rifampicin
rpoB 761353 p.Gly516Ala missense_variant 0.52 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.52 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.55 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.55 rifampicin
rpoB 761384 c.1578C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761396 c.1590G>A synonymous_variant 0.63 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.56 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.48 rifampicin
rpoB 761437 p.Ala544Asp missense_variant 0.48 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.48 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.48 rifampicin
rpoB 761451 p.Val549Thr missense_variant 0.45 rifampicin
rpoB 761457 c.1651_1653delCCGinsGC frameshift_variant&missense_variant 0.45 rifampicin
rpoB 761462 c.1656C>G synonymous_variant 0.52 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.63 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.7 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.73 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.79 rifampicin
rpoB 761508 c.1702_1704delTCTinsGC frameshift_variant&missense_variant 0.79 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.86 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.84 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.82 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.84 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.86 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.86 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsAG frameshift_variant&missense_variant 0.87 rifampicin
rpoB 761735 c.1929C>A synonymous_variant 0.87 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.77 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.76 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.8 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.73 rifampicin
rpoB 761819 c.2013G>A synonymous_variant 0.68 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.51 rifampicin
rpoB 761846 c.2040G>A synonymous_variant 0.41 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.4 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.39 rifampicin
rpoB 761855 p.Ile683Met missense_variant 0.38 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.36 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>G synonymous_variant 0.36 rifampicin
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.36 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.4 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.42 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.49 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.46 rifampicin
rpoB 761892 p.Ile696Val missense_variant 0.47 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.54 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.56 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.59 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.59 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762011 c.2205G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762029 c.2223C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>T synonymous_variant 0.84 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.85 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.84 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.83 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.81 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.8 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.83 rifampicin
rpoB 762209 c.2403C>T synonymous_variant 0.82 rifampicin
rpoB 762218 c.2412T>G synonymous_variant 0.83 rifampicin
rpoB 762233 c.2427G>T synonymous_variant 0.83 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.82 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.81 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.78 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.82 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.86 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.85 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.87 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.88 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.87 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.86 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.83 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.83 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.8 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.81 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.67 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.67 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.68 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.68 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.7 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.69 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.69 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.74 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.78 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.76 rifampicin
rpoC 762587 c.-783G>A upstream_gene_variant 0.74 rifampicin
rpoB 762599 c.2793T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 762605 c.-765T>C upstream_gene_variant 0.74 rifampicin
rpoC 762608 c.-762C>G upstream_gene_variant 0.7 rifampicin
rpoB 762631 p.Ala942Gly missense_variant 0.59 rifampicin
rpoB 762635 c.2829_2838delCAAGGGGGTTinsA conservative_inframe_deletion&synonymous_variant 0.58 rifampicin
rpoC 762659 c.-711C>G upstream_gene_variant 0.61 rifampicin
rpoC 762660 c.-710A>C upstream_gene_variant 0.61 rifampicin
rpoB 762663 c.2857C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762671 p.Asp955Glu missense_variant 0.66 rifampicin
rpoB 762678 c.2872_2874delCTCinsTG frameshift_variant&missense_variant 0.66 rifampicin
rpoC 762686 c.-684G>C upstream_gene_variant 0.66 rifampicin
rpoB 762687 p.Gln961Glu missense_variant 0.66 rifampicin
rpoB 762696 p.Ala964Lys missense_variant 0.68 rifampicin
rpoC 762701 c.-669T>C upstream_gene_variant 0.71 rifampicin
rpoC 762707 c.-663G>C upstream_gene_variant 0.76 rifampicin
rpoC 762734 c.-636G>A upstream_gene_variant 0.76 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>T upstream_gene_variant 0.79 rifampicin
rpoB 762760 p.Cys985Ser missense_variant 0.79 rifampicin Uncertain significance
rpoB 762785 p.Asp993Glu missense_variant 0.85 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.86 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.87 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.86 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.9 rifampicin
rpoB 762868 p.Tyr1021Phe missense_variant 0.86 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.86 rifampicin
rpoC 763179 c.-191C>T upstream_gene_variant 0.86 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.8 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.8 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.81 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763217 c.-153G>C upstream_gene_variant 0.8 rifampicin
rpoC 763220 c.-150G>C upstream_gene_variant 0.82 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.82 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.82 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.8 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.75 rifampicin
rpoC 763259 c.-111G>C upstream_gene_variant 0.76 rifampicin
rpoC 763262 c.-108C>T upstream_gene_variant 0.75 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763373 c.4_6delCTCinsTA frameshift_variant&missense_variant 0.55 rifampicin
rpoC 763396 c.27A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.69 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.7 rifampicin
rpoC 763420 c.51G>C synonymous_variant 0.72 rifampicin
rpoC 763430 c.61A>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763435 c.66A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763450 c.81G>A synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.76 rifampicin
rpoC 763484 c.115_117delCTTinsTG frameshift_variant&missense_variant 0.76 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>T synonymous_variant 0.79 rifampicin
rpoC 763621 c.252C>G synonymous_variant 0.78 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.79 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.75 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.74 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.74 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.72 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.71 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.62 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.57 rifampicin
rpoC 763781 p.Ser138Gly missense_variant 0.45 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.44 rifampicin
rpoC 763796 p.Met143Leu missense_variant 0.45 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.47 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.45 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.48 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.39 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.39 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.44 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.42 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.42 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.45 rifampicin
rpoC 763903 c.534G>A synonymous_variant 0.61 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.67 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.7 rifampicin
rpoC 763933 c.564C>G synonymous_variant 0.69 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.69 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.69 rifampicin
rpoC 763972 c.603C>T synonymous_variant 0.79 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.78 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.76 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.77 rifampicin
rpoC 764011 c.642T>C synonymous_variant 0.81 rifampicin
rpoC 764024 c.655_657delTTGinsCA frameshift_variant&missense_variant 0.81 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.87 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.85 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.84 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.83 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.82 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.84 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.86 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.84 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.88 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.88 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.84 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.83 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.86 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.78 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.8 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.8 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.8 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.84 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.88 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.86 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.87 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764618 c.1249C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>A synonymous_variant 0.81 rifampicin
rpoC 764680 c.1311G>A synonymous_variant 0.81 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.84 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.84 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.8 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.79 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.81 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.8 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.82 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.81 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.83 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765065 c.1696C>T synonymous_variant 0.79 rifampicin
rpoC 765076 c.1707A>G synonymous_variant 0.74 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.75 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 765142 c.1773G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765247 c.1878C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765277 c.1908G>A synonymous_variant 0.58 rifampicin
rpoC 765281 p.Thr638Glu missense_variant 0.56 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.59 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.56 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.56 rifampicin Uncertain significance
rpoC 765305 p.Ile646Val missense_variant 0.56 rifampicin Uncertain significance
rpoC 765317 c.1948_1950delCTAinsTG frameshift_variant&stop_gained 0.55 rifampicin
rpoC 765325 c.1956_1957insG frameshift_variant 0.55 rifampicin
rpoC 765329 c.1961delG frameshift_variant 0.57 rifampicin
rpoC 765334 c.1965C>T synonymous_variant 0.61 rifampicin
rpoC 765343 c.1974G>A synonymous_variant 0.67 rifampicin
rpoC 765346 c.1977C>T synonymous_variant 0.72 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765358 p.Met663Ile missense_variant 0.72 rifampicin Uncertain significance
rpoC 765364 c.1995G>A synonymous_variant 0.72 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.75 rifampicin
rpoC 765404 p.Leu679Thr missense_variant 0.75 rifampicin Uncertain significance
rpoC 765409 c.2040T>C synonymous_variant 0.77 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.78 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.85 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.87 rifampicin
rpoC 765502 c.2133G>A synonymous_variant 0.85 rifampicin
rpoC 765529 c.2160C>T synonymous_variant 0.85 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.84 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.82 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.79 rifampicin
rpoC 765565 c.2196G>C synonymous_variant 0.79 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.82 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.82 rifampicin
rpoC 765592 c.2223C>T synonymous_variant 0.8 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.81 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.76 rifampicin Uncertain significance
rpoC 765628 c.2259G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.76 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.75 rifampicin
rpoC 765790 c.2421C>G synonymous_variant 0.74 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.74 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.76 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765865 c.2496C>T synonymous_variant 0.71 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.7 rifampicin Uncertain significance
rpoC 765883 c.2514C>G synonymous_variant 0.7 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.69 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.69 rifampicin
rpoC 765937 c.2568T>G synonymous_variant 0.65 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.64 rifampicin
rpoC 765985 c.2616C>T synonymous_variant 0.62 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.53 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.51 rifampicin
rpoC 766034 p.His889Ala missense_variant 0.47 rifampicin
rpoC 766043 p.Gln892Gly missense_variant 0.49 rifampicin
rpoC 766057 c.2688C>T synonymous_variant 0.5 rifampicin
rpoC 766061 p.Val898Thr missense_variant 0.5 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.5 rifampicin
rpoC 766243 c.2874C>G synonymous_variant 0.35 rifampicin
rpoC 766249 c.2880C>G synonymous_variant 0.5 rifampicin
rpoC 766258 c.2889T>G synonymous_variant 0.5 rifampicin
rpoC 766264 c.2895G>A synonymous_variant 0.49 rifampicin
rpoC 766270 c.2901G>C synonymous_variant 0.49 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.52 rifampicin
rpoC 766276 c.2907C>G synonymous_variant 0.53 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.6 rifampicin
rpoC 766288 c.2919C>A synonymous_variant 0.68 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.78 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.8 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.83 rifampicin
rpoC 766360 c.2991C>T synonymous_variant 0.84 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.84 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.86 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.88 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.87 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.88 rifampicin
rpoC 766459 c.3090G>A synonymous_variant 0.86 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.9 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.89 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.9 rifampicin
rpoC 766495 c.3126C>G synonymous_variant 0.9 rifampicin
rpoC 766519 c.3150C>T synonymous_variant 0.9 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.9 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.88 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.86 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.88 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.91 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.92 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.93 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.92 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.9 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.89 rifampicin
rpoC 766652 p.Ser1095Thr missense_variant 0.9 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.87 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.86 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.86 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.83 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.83 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.83 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.83 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.84 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.84 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.84 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.84 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.81 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.82 rifampicin
rpoC 766756 c.3387G>A synonymous_variant 0.79 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766798 c.3429C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.76 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>A synonymous_variant 0.73 rifampicin
rpoC 766891 c.3522G>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.76 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.75 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.76 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766942 c.3573C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.79 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.82 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.81 rifampicin
rpoC 766988 c.3619_3621delCTGinsTA frameshift_variant&stop_gained 0.84 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.92 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>G synonymous_variant 0.91 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767099 p.Lys1244Arg missense_variant 0.84 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767155 c.3786C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>G synonymous_variant 0.79 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.76 rifampicin
rpoC 767185 c.3816G>A synonymous_variant 0.74 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>T synonymous_variant 0.7 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.7 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767257 c.3888C>T synonymous_variant 0.65 rifampicin
rpoC 767263 c.3894T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767266 c.3897G>C synonymous_variant 0.65 rifampicin
rpoC 767272 c.3903C>T synonymous_variant 0.63 rifampicin
rpoC 767275 c.3906T>G synonymous_variant 0.62 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.65 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775904 c.2577G>A synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.5 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 775939 p.Ala848Ser missense_variant 0.5 clofazimine
bedaquiline
mmpL5 775940 c.2541C>G synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 775943 c.2538C>G synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781134 c.-426T>C upstream_gene_variant 0.6 streptomycin
rpsL 781143 c.-417T>C upstream_gene_variant 0.57 streptomycin
rpsL 781156 c.-404_-402delCTCinsTG upstream_gene_variant 0.5 streptomycin
rpsL 781161 c.-399G>A upstream_gene_variant 0.46 streptomycin
rpsL 781164 c.-396T>C upstream_gene_variant 0.49 streptomycin
rpsL 781174 c.-386C>T upstream_gene_variant 0.5 streptomycin
rpsL 781179 c.-381T>C upstream_gene_variant 0.51 streptomycin
rpsL 781182 c.-378G>T upstream_gene_variant 0.46 streptomycin
rpsL 781185 c.-375T>C upstream_gene_variant 0.51 streptomycin
rpsL 781194 c.-366G>C upstream_gene_variant 0.51 streptomycin
rpsL 781224 c.-336T>C upstream_gene_variant 0.56 streptomycin
rpsL 781230 c.-330T>C upstream_gene_variant 0.51 streptomycin
rpsL 781232 c.-328C>T upstream_gene_variant 0.5 streptomycin
rpsL 781236 c.-324G>T upstream_gene_variant 0.52 streptomycin
rpsL 781239 c.-321C>T upstream_gene_variant 0.5 streptomycin
rpsL 781240 c.-320A>T upstream_gene_variant 0.49 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.36 streptomycin
rpsL 781592 c.33T>G synonymous_variant 0.4 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.43 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.41 streptomycin
rpsL 781605 p.Ile16Leu missense_variant 0.44 streptomycin
rpsL 781608 c.49_51delAGTinsGC frameshift_variant&missense_variant 0.44 streptomycin Uncertain significance
rpsL 781628 c.69T>C synonymous_variant 0.63 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.61 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.74 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.75 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.76 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.74 streptomycin
rpsL 781664 c.105C>G synonymous_variant 0.76 streptomycin
rpsL 781679 c.120C>G synonymous_variant 0.8 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.79 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.82 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.82 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.82 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.82 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.82 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.82 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.82 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.84 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.86 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.87 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.86 streptomycin
rpsL 781778 c.219C>T synonymous_variant 0.87 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.88 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.87 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.86 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.87 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.87 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.88 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.85 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.84 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.84 streptomycin
rplC 800516 c.-293G>C upstream_gene_variant 0.59 linezolid
rplC 800531 c.-278T>C upstream_gene_variant 0.65 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.68 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.69 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.69 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.7 linezolid
rplC 800579 c.-230C>G upstream_gene_variant 0.71 linezolid
rplC 800585 c.-224T>C upstream_gene_variant 0.73 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.71 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.72 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.73 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.72 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.71 linezolid
rplC 800642 c.-167C>T upstream_gene_variant 0.75 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.77 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.77 linezolid
rplC 800657 c.-152G>A upstream_gene_variant 0.77 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.7 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.67 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.61 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.6 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.6 linezolid
rplC 800745 c.-64_-62delCTCinsTG upstream_gene_variant 0.6 linezolid
rplC 800753 c.-56C>T upstream_gene_variant 0.64 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.64 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.64 linezolid
rplC 800798 c.-11_-8delTGGAinsC upstream_gene_variant 0.4 linezolid
rplC 800806 c.-3G>A upstream_gene_variant 0.4 linezolid
rplC 800814 c.6A>G synonymous_variant 0.38 linezolid
rplC 800815 c.7C>A synonymous_variant 0.38 linezolid
rplC 800819 p.Lys4Arg missense_variant 0.36 linezolid
rplC 800829 c.21C>G synonymous_variant 0.38 linezolid
rplC 800832 c.24T>C synonymous_variant 0.38 linezolid
rplC 800844 c.36T>C synonymous_variant 0.43 linezolid
rplC 800856 c.48A>G synonymous_variant 0.48 linezolid
rplC 800865 p.Glu19Asp missense_variant 0.44 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.44 linezolid
rplC 800872 c.64A>C synonymous_variant 0.48 linezolid
rplC 800877 c.69A>T synonymous_variant 0.46 linezolid
rplC 800880 c.72A>T synonymous_variant 0.46 linezolid
rplC 800889 c.81C>G synonymous_variant 0.48 linezolid
rplC 800898 c.90G>A synonymous_variant 0.52 linezolid
rplC 800916 c.108A>G synonymous_variant 0.41 linezolid
rplC 800919 c.111C>T synonymous_variant 0.41 linezolid
rplC 800922 c.114C>A synonymous_variant 0.41 linezolid
rplC 800931 c.123G>A synonymous_variant 0.43 linezolid
rplC 800934 c.126C>G synonymous_variant 0.43 linezolid
rplC 800937 c.129A>G synonymous_variant 0.43 linezolid
rplC 800940 c.132C>T synonymous_variant 0.43 linezolid
rplC 800946 c.138T>C synonymous_variant 0.39 linezolid
rplC 800949 c.141T>C synonymous_variant 0.38 linezolid
rplC 800955 c.147C>A synonymous_variant 0.39 linezolid
rplC 800962 c.154C>T synonymous_variant 0.4 linezolid
rplC 800970 c.162T>C synonymous_variant 0.43 linezolid Not assoc w R - Interim
rplC 800976 c.168G>A synonymous_variant 0.44 linezolid
rplC 800982 c.174C>T synonymous_variant 0.43 linezolid
rplC 800985 c.177A>T synonymous_variant 0.43 linezolid
rplC 800988 c.180C>G synonymous_variant 0.45 linezolid
rplC 801153 c.345G>C synonymous_variant 0.38 linezolid
rplC 801156 c.348T>C synonymous_variant 0.43 linezolid
rplC 801174 c.366T>C synonymous_variant 0.62 linezolid
rplC 801177 c.369C>T synonymous_variant 0.62 linezolid
rplC 801183 c.375C>A synonymous_variant 0.62 linezolid
rplC 801186 c.378C>T synonymous_variant 0.59 linezolid
rplC 801201 c.393C>T synonymous_variant 0.64 linezolid
rplC 801210 c.402T>G synonymous_variant 0.68 linezolid Not assoc w R - Interim
rplC 801222 c.414T>C synonymous_variant 0.68 linezolid
rplC 801228 c.420T>C synonymous_variant 0.68 linezolid
rplC 801231 c.423C>T synonymous_variant 0.67 linezolid
rplC 801249 c.441T>G synonymous_variant 0.74 linezolid
rplC 801255 c.447C>T synonymous_variant 0.76 linezolid
rplC 801267 c.459A>T synonymous_variant 0.76 linezolid
rplC 801270 c.462T>C synonymous_variant 0.76 linezolid
rplC 801321 c.513C>T synonymous_variant 0.71 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.7 linezolid
rplC 801327 c.519C>T synonymous_variant 0.69 linezolid
rplC 801337 p.Val177Thr missense_variant 0.69 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.69 linezolid
rplC 801348 c.540T>G synonymous_variant 0.73 linezolid
rplC 801357 c.549T>C synonymous_variant 0.75 linezolid
rplC 801369 c.561C>T synonymous_variant 0.74 linezolid
rplC 801393 c.585G>A synonymous_variant 0.64 linezolid
rplC 801402 c.594T>C synonymous_variant 0.64 linezolid
rplC 801413 p.Thr202Asn missense_variant 0.55 linezolid
rplC 801423 c.615G>C synonymous_variant 0.57 linezolid
rplC 801427 p.Met207Val missense_variant 0.51 linezolid
rplC 801432 c.624C>T synonymous_variant 0.43 linezolid
rplC 801438 c.630T>C synonymous_variant 0.36 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303441 c.511T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303455 c.525C>G synonymous_variant 0.79 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303474 c.544C>T synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1303480 p.Gln184Glu missense_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1303485 c.555C>T synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>A synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303515 c.585G>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303536 c.606G>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>A synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303542 c.612C>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303606 p.Lys226Arg missense_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1303620 c.690C>T synonymous_variant 0.8 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303632 c.702T>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1303662 c.732C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303663 c.733C>T synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>A synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303713 c.783C>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1303722 c.792C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.63 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303761 c.831T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303791 c.861C>T synonymous_variant 0.53 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303794 c.864A>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304013 c.1083G>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304061 c.1131G>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304088 c.1158C>T synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304098 p.Gln390Glu missense_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304124 c.1194C>T synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304133 c.1203G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304136 c.1206C>T synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304465 p.Gly512Ala missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304481 c.1551T>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304484 c.1554C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304486 p.Thr519Asn missense_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304493 c.1563C>T synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304496 c.1566T>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304503 c.1573C>T synonymous_variant 0.62 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304508 p.Glu526Asp missense_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>T synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304517 c.1587C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304538 c.1608C>T synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304541 c.1611C>G synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304598 c.1668C>T synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304637 c.1707G>A synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>T synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304700 c.1770G>A synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304706 c.1776C>T synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304712 c.1782C>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304751 c.1821C>T synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304772 c.1842C>T synonymous_variant 0.61 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304778 c.1848T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304823 c.1893C>T synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>A synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>G synonymous_variant 0.49 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304871 c.1941G>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304877 c.1947T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304901 c.1971C>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304922 c.1992C>T synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>A synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304943 c.2013C>T synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304955 p.Glu675Asp missense_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304979 c.2049C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Glu missense_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>T synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1305025 p.Glu699Gln missense_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1305074 p.Ser715Asn missense_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>T synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1305093 c.2163C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1305106 c.2176C>T synonymous_variant 0.55 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305113 p.Asp728Gly missense_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305123 c.2193C>T synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.52 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305150 c.2220C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305154 c.2224T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305159 c.2229G>A synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305168 c.2238C>T synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305173 p.Asn748Ser missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305177 c.2247A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305186 c.2256C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
sigE 1364634 c.222C>A synonymous_variant 0.47 pyrazinamide
sigE 1364649 c.237C>G synonymous_variant 0.69 pyrazinamide
sigE 1364650 c.238_240delACCinsGG frameshift_variant&missense_variant 0.67 pyrazinamide Uncertain significance
sigE 1364676 c.264C>G synonymous_variant 0.72 pyrazinamide
sigE 1364688 c.276C>A synonymous_variant 0.74 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.72 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.73 pyrazinamide
sigE 1364715 c.303G>T synonymous_variant 0.73 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.74 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.75 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.73 pyrazinamide
sigE 1364751 c.339C>T synonymous_variant 0.73 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.71 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.73 pyrazinamide
sigE 1364772 c.360G>A synonymous_variant 0.74 pyrazinamide
sigE 1364778 c.366G>A synonymous_variant 0.71 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.71 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.72 pyrazinamide
sigE 1364793 c.381C>T synonymous_variant 0.69 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.67 pyrazinamide
sigE 1364802 c.390C>G synonymous_variant 0.76 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.78 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.78 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.8 pyrazinamide
sigE 1364844 c.432C>T synonymous_variant 0.8 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.8 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.8 pyrazinamide
sigE 1364865 c.453G>T synonymous_variant 0.8 pyrazinamide
sigE 1364866 p.Ala152Ser missense_variant 0.8 pyrazinamide
sigE 1364872 c.460_462delATCinsGT frameshift_variant&missense_variant 0.77 pyrazinamide Uncertain significance
sigE 1364889 c.477A>G synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
sigE 1364898 c.486C>T synonymous_variant 0.75 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.79 pyrazinamide
sigE 1364949 c.537C>T synonymous_variant 0.77 pyrazinamide
sigE 1364952 c.540A>G synonymous_variant 0.75 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.65 pyrazinamide
sigE 1364962 p.Pro184Ala missense_variant 0.65 pyrazinamide
sigE 1364976 c.564T>G synonymous_variant 0.67 pyrazinamide
sigE 1364979 c.567C>G synonymous_variant 0.67 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.67 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.69 pyrazinamide
sigE 1364989 c.577_579delCTGinsTA frameshift_variant&stop_gained 0.69 pyrazinamide Uncertain significance
sigE 1365000 c.588G>A synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
sigE 1365003 c.591T>C synonymous_variant 0.67 pyrazinamide
sigE 1365006 c.594T>G synonymous_variant 0.65 pyrazinamide
sigE 1365019 c.607C>T synonymous_variant 0.67 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.69 pyrazinamide
sigE 1365039 c.627G>C synonymous_variant 0.62 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.61 pyrazinamide
sigE 1365045 c.633C>T synonymous_variant 0.65 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461083 c.39T>C synonymous_variant 0.29 bedaquiline
atpE 1461093 p.Met17Leu missense_variant 0.27 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.27 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.3 bedaquiline
atpE 1461108 p.Ile22Val missense_variant 0.29 bedaquiline
atpE 1461118 p.Gly25Ala missense_variant 0.32 bedaquiline
atpE 1461128 c.84C>T synonymous_variant 0.33 bedaquiline
atpE 1461131 c.87T>C synonymous_variant 0.32 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.32 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.33 bedaquiline
atpE 1461158 c.114T>C synonymous_variant 0.35 bedaquiline
atpE 1461161 c.117C>T synonymous_variant 0.35 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.38 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.43 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.43 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.45 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.43 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.45 bedaquiline
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473291 n.1446_1455delGGGAGGGAGCinsAAGGGAGGGAGT non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
inhA 1673499 c.-703T>G upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1673502 c.-700C>G upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673505 c.-697A>C upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673520 c.-682C>T upstream_gene_variant 0.41 ethionamide
isoniazid
inhA 1673523 c.-679G>T upstream_gene_variant 0.41 ethionamide
isoniazid
inhA 1673535 c.-667A>C upstream_gene_variant 0.49 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.51 ethionamide
isoniazid
fabG1 1673549 p.Ala37Glu missense_variant 0.5 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.56 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.57 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.57 ethionamide
isoniazid
fabG1 1673591 p.Ala51Val missense_variant 0.57 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.57 ethionamide
isoniazid
fabG1 1673596 c.157_159delAAGinsGA frameshift_variant&missense_variant 0.57 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.63 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.65 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.65 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.62 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.64 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.66 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.55 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.65 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.65 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.61 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.59 ethionamide
isoniazid
inhA 1673754 c.-448C>T upstream_gene_variant 0.6 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.62 ethionamide
isoniazid
fabG1 1673890 p.Ala151Ser missense_variant 0.74 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.75 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.73 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.72 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.72 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.72 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.75 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.81 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.81 ethionamide
isoniazid
fabG1 1673962 p.Asn175Gly missense_variant 0.81 ethionamide
isoniazid
inhA 1673988 c.-214G>C upstream_gene_variant 0.81 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.8 ethionamide
isoniazid
inhA 1674018 c.-184G>A upstream_gene_variant 0.79 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.78 ethionamide
isoniazid
inhA 1674027 c.-175G>A upstream_gene_variant 0.78 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.71 ethionamide
isoniazid
inhA 1674042 c.-160G>C upstream_gene_variant 0.7 ethionamide
isoniazid Uncertain significance
inhA 1674045 c.-157G>A upstream_gene_variant 0.69 ethionamide
isoniazid
fabG1 1674049 p.Gln204Glu missense_variant 0.67 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.69 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.69 ethionamide
isoniazid
inhA 1674109 c.-93C>T upstream_gene_variant 0.72 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674114 c.-88T>A upstream_gene_variant 0.72 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674123 c.-79T>C upstream_gene_variant 0.73 ethionamide
isoniazid
inhA 1674129 c.-73C>T upstream_gene_variant 0.72 ethionamide
isoniazid
inhA 1674132 c.-70T>C upstream_gene_variant 0.72 ethionamide
isoniazid
fabG1 1674136 p.Ser233Ala missense_variant 0.71 ethionamide
isoniazid
inhA 1674141 c.-61T>C upstream_gene_variant 0.73 ethionamide
isoniazid
inhA 1674165 c.-37C>T upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1674171 c.-31T>C upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1674184 c.-18_-17insGAAA upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1674190 c.-11delC upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1674199 c.-3C>G upstream_gene_variant 0.65 ethionamide
isoniazid Uncertain significance
inhA 1674205 p.Thr2Ala missense_variant 0.66 ethionamide
isoniazid Uncertain significance
inhA 1674216 c.15G>C synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674219 p.Asp6Glu missense_variant 0.66 ethionamide
isoniazid
inhA 1674237 c.36T>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674243 c.42A>G synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674256 p.Ser19Ala missense_variant 0.51 ethionamide
isoniazid Uncertain significance
inhA 1674531 c.330C>T synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674534 c.333G>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674537 c.336C>A synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.25 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.28 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674573 c.372G>A synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674585 c.384T>A synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674588 c.387G>A synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.44 ethionamide
isoniazid
inhA 1674618 c.417C>T synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674625 c.424_426delGGTinsAC frameshift_variant&missense_variant 0.59 ethionamide
isoniazid
inhA 1674628 c.427_429delTCCinsGG frameshift_variant&missense_variant 0.58 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674645 c.444C>T synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674651 c.450C>T synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.67 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674732 c.531C>T synonymous_variant 0.77 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.72 ethionamide
isoniazid
inhA 1674741 c.540C>T synonymous_variant 0.7 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674742 p.Lys181Gln missense_variant 0.71 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.77 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.77 ethionamide
isoniazid
inhA 1674771 c.570C>A synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.73 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674792 c.591G>T synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.7 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.73 ethionamide
isoniazid
inhA 1674813 c.612C>T synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674835 p.Gly212Ser missense_variant 0.76 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674839 p.Ala213Gly missense_variant 0.76 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.77 ethionamide
isoniazid
inhA 1674850 c.649C>T synonymous_variant 0.76 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674859 p.Glu220Gln missense_variant 0.76 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674876 c.675C>A synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.76 ethionamide
isoniazid
inhA 1674888 c.687C>T synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674900 c.699G>A synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.67 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674912 c.711G>A synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674915 c.714C>T synonymous_variant 0.71 ethionamide
isoniazid
inhA 1674924 c.723G>A synonymous_variant 0.76 ethionamide
isoniazid
inhA 1674927 c.726G>C synonymous_variant 0.77 ethionamide
isoniazid
inhA 1674934 p.Leu245Val missense_variant 0.76 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674951 c.750G>A synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674966 c.765T>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674990 c.789C>A synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674993 c.792G>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674999 c.798C>G synonymous_variant 0.6 ethionamide
isoniazid
inhA 1675002 c.801A>G synonymous_variant 0.6 ethionamide
isoniazid
inhA 1675010 c.809_*5delAGAACGCinsG frameshift_variant&stop_lost&splice_region_variant 0.62 ethionamide
isoniazid
rpsA 1833536 c.-6_-3delAACAinsCCC upstream_gene_variant 0.47 pyrazinamide
rpsA 1833568 c.27G>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>C synonymous_variant 0.64 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.65 pyrazinamide
rpsA 1833607 c.66T>C synonymous_variant 0.68 pyrazinamide
rpsA 1833610 c.69C>A synonymous_variant 0.68 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.69 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.69 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.72 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.74 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.78 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.82 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.82 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.83 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.82 pyrazinamide
rpsA 1833709 c.168C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.88 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.86 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.86 pyrazinamide
rpsA 1833772 c.231C>T synonymous_variant 0.85 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.83 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.79 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.8 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.8 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.81 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.81 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.84 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.85 pyrazinamide
rpsA 1833889 c.348C>T synonymous_variant 0.85 pyrazinamide
rpsA 1833901 c.360G>A synonymous_variant 0.84 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.85 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.87 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.9 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.91 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.93 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.94 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.94 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.93 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.92 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.9 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.89 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.84 pyrazinamide
rpsA 1834138 c.597C>G synonymous_variant 0.78 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.73 pyrazinamide Uncertain significance
rpsA 1834162 c.621A>G synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.76 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.77 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.79 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.78 pyrazinamide
rpsA 1834216 c.675C>T synonymous_variant 0.79 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.76 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.75 pyrazinamide
rpsA 1834285 c.744G>C synonymous_variant 0.84 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.86 pyrazinamide
rpsA 1834300 c.759G>A synonymous_variant 0.86 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.83 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.83 pyrazinamide
rpsA 1834357 c.816T>G synonymous_variant 0.84 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.81 pyrazinamide
rpsA 1834381 c.840G>A synonymous_variant 0.83 pyrazinamide
rpsA 1834396 c.855G>A synonymous_variant 0.85 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834420 c.879C>T synonymous_variant 0.88 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.89 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.89 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.9 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.9 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.89 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834531 c.990C>T synonymous_variant 0.86 pyrazinamide
rpsA 1834540 c.999G>A synonymous_variant 0.87 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834597 c.1056C>T synonymous_variant 0.82 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.8 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.8 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.8 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.74 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.74 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.77 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.77 pyrazinamide
rpsA 1834741 c.1200C>G synonymous_variant 0.77 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.78 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.75 pyrazinamide
rpsA 1834765 c.1224_1226delAAAinsC frameshift_variant&missense_variant 0.68 pyrazinamide Uncertain significance
rpsA 1834771 p.Gln410His missense_variant 0.68 pyrazinamide
rpsA 1834772 p.Arg411Ser missense_variant 0.68 pyrazinamide
rpsA 1834777 c.1236_1237insAG frameshift_variant 0.68 pyrazinamide Uncertain significance
rpsA 1834780 c.1239A>G synonymous_variant 0.68 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.67 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.85 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.85 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.83 linezolid
tsnR 1853384 c.-222G>A upstream_gene_variant 0.78 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.78 linezolid
tsnR 1853390 c.-216G>T upstream_gene_variant 0.74 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.77 linezolid
tsnR 1853418 c.-188_-186delCTTinsTG upstream_gene_variant 0.8 linezolid
tsnR 1853426 c.-180G>A upstream_gene_variant 0.83 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.82 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.8 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.8 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.8 linezolid
tsnR 1853465 c.-141C>T upstream_gene_variant 0.83 linezolid
tsnR 1853474 c.-132C>A upstream_gene_variant 0.81 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.82 linezolid
tsnR 1853481 c.-125_-123delATCinsGG upstream_gene_variant 0.77 linezolid
tsnR 1853489 c.-117C>T upstream_gene_variant 0.76 linezolid
tsnR 1853490 c.-116_-114delCCGinsGT upstream_gene_variant 0.76 linezolid
tsnR 1853501 c.-105C>T upstream_gene_variant 0.74 linezolid
tsnR 1853507 c.-99G>C upstream_gene_variant 0.76 linezolid
tsnR 1853528 c.-78G>C upstream_gene_variant 0.74 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.74 linezolid
tsnR 1853552 c.-54C>G upstream_gene_variant 0.72 linezolid
tsnR 1853561 c.-45G>A upstream_gene_variant 0.66 linezolid
tsnR 1853567 c.-39C>T upstream_gene_variant 0.52 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064897 c.-169C>T upstream_gene_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064900 c.-172G>A upstream_gene_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064912 c.-184A>G upstream_gene_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064918 c.-190G>T upstream_gene_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064934 c.-208_-206delCTCinsGCT upstream_gene_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064975 c.-247G>C upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-253_-251delGGCinsCT upstream_gene_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101957 c.1086C>T synonymous_variant 0.45 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.48 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>C synonymous_variant 0.45 ethionamide
delamanid
isoniazid
ndh 2101969 c.1074G>A synonymous_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>A synonymous_variant 0.43 ethionamide
delamanid
isoniazid
ndh 2101978 c.1063_1065delAACinsGT frameshift_variant&missense_variant 0.41 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101984 c.1059C>T synonymous_variant 0.43 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102005 c.1038G>A synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102011 c.1032C>G synonymous_variant 0.42 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102014 p.Val343Ala missense_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102017 c.1026C>T synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.41 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102062 p.Glu327Asp missense_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2102065 c.978G>C synonymous_variant 0.34 ethionamide
delamanid
isoniazid
ndh 2102068 c.975T>G synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102071 c.972C>A synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102077 c.966T>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102083 c.960G>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102441 p.Phe201Tyr missense_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102443 c.600A>C synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102641 c.402C>T synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102659 c.384C>T synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102671 c.372T>C synonymous_variant 0.4 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102677 c.366C>T synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102680 c.363T>C synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102683 c.360T>C synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2102686 c.357G>C synonymous_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2102694 p.Val117Ile missense_variant 0.4 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102707 c.336C>T synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102710 c.333C>G synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102713 c.330C>G synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102716 c.327A>G synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102728 c.315T>C synonymous_variant 0.37 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155071 c.1041T>C synonymous_variant 0.53 isoniazid
katG 2155080 c.1032G>C synonymous_variant 0.56 isoniazid
katG 2155113 c.999C>G synonymous_variant 0.55 isoniazid
katG 2155117 p.Phe332Tyr missense_variant 0.52 isoniazid
katG 2155131 c.981A>G synonymous_variant 0.42 isoniazid Not assoc w R - Interim
katG 2155134 c.978G>C synonymous_variant 0.39 isoniazid
katG 2155143 p.Asn323Pro missense_variant 0.39 isoniazid
katG 2155152 c.960A>C synonymous_variant 0.38 isoniazid
katG 2155155 c.957C>G synonymous_variant 0.38 isoniazid
katG 2155158 c.954G>A synonymous_variant 0.35 isoniazid
katG 2155164 c.948C>G synonymous_variant 0.36 isoniazid
katG 2155176 c.936G>C synonymous_variant 0.38 isoniazid
katG 2155182 c.930G>A synonymous_variant 0.38 isoniazid
katG 2155185 c.927T>C synonymous_variant 0.38 isoniazid
katG 2155191 c.921A>T synonymous_variant 0.39 isoniazid
katG 2155195 p.Thr306Ser missense_variant 0.43 isoniazid
katG 2155203 c.909G>C synonymous_variant 0.43 isoniazid
katG 2155614 c.498T>C synonymous_variant 0.29 isoniazid
katG 2155632 c.480A>C synonymous_variant 0.65 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.72 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.72 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.78 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.77 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.72 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.75 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.78 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.73 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.72 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.72 isoniazid
katG 2155737 c.375C>T synonymous_variant 0.67 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.69 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.69 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.69 isoniazid
katG 2155767 c.345C>T synonymous_variant 0.62 isoniazid
katG 2155770 c.342C>T synonymous_variant 0.56 isoniazid
katG 2155782 c.330C>G synonymous_variant 0.39 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517935 c.-180C>T upstream_gene_variant 0.86 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.85 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.84 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.79 isoniazid
kasA 2517994 c.-121C>A upstream_gene_variant 0.75 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.69 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.62 isoniazid
kasA 2518031 c.-84G>C upstream_gene_variant 0.57 isoniazid
kasA 2518034 c.-81T>C upstream_gene_variant 0.55 isoniazid
kasA 2518041 c.-74T>C upstream_gene_variant 0.53 isoniazid
kasA 2518049 c.-66G>C upstream_gene_variant 0.54 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.47 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.47 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.5 isoniazid
kasA 2518156 c.42T>G synonymous_variant 0.5 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.5 isoniazid
kasA 2518171 c.57C>G synonymous_variant 0.53 isoniazid
kasA 2518172 p.Thr20Glu missense_variant 0.53 isoniazid
kasA 2518177 c.63G>C synonymous_variant 0.5 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.44 isoniazid
kasA 2518190 p.Ser26Gly missense_variant 0.42 isoniazid
kasA 2518193 c.79_81delCCGinsGC frameshift_variant&missense_variant 0.42 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.42 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.69 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.78 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.78 isoniazid
kasA 2518261 p.Glu49Asp missense_variant 0.78 isoniazid
kasA 2518263 p.Phe50Tyr missense_variant 0.78 isoniazid
kasA 2518265 p.Val51Ile missense_variant 0.78 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.76 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.81 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.81 isoniazid
kasA 2518300 c.186T>G synonymous_variant 0.81 isoniazid
kasA 2518312 c.198T>C synonymous_variant 0.73 isoniazid
kasA 2518322 p.Ser70Asp missense_variant 0.72 isoniazid
kasA 2518336 c.222A>G synonymous_variant 0.81 isoniazid
kasA 2518339 c.225C>G synonymous_variant 0.81 isoniazid
kasA 2518342 p.Asp76Glu missense_variant 0.81 isoniazid
kasA 2518348 c.234A>G synonymous_variant 0.81 isoniazid
kasA 2518360 c.246C>T synonymous_variant 0.76 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.61 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.65 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.72 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.82 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.82 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.77 isoniazid
kasA 2518571 p.Val153Thr missense_variant 0.77 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.77 isoniazid
kasA 2518587 p.Leu158Arg missense_variant 0.74 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.74 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.78 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.81 isoniazid
kasA 2518612 c.498C>T synonymous_variant 0.82 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.85 isoniazid
kasA 2518644 p.Ala177Gly missense_variant 0.86 isoniazid
kasA 2518663 c.549T>G synonymous_variant 0.84 isoniazid
kasA 2518666 c.552G>A synonymous_variant 0.83 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.84 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.81 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.79 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.78 isoniazid
kasA 2518694 p.Val194Ile missense_variant 0.78 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.8 isoniazid
kasA 2518717 c.603C>G synonymous_variant 0.8 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.8 isoniazid
kasA 2518738 c.624G>A synonymous_variant 0.8 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.81 isoniazid
kasA 2518765 c.651G>T synonymous_variant 0.81 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.77 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.75 isoniazid
kasA 2518786 c.672G>A synonymous_variant 0.75 isoniazid
kasA 2518787 c.673_675delCGGinsGC frameshift_variant&missense_variant 0.75 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.78 isoniazid
kasA 2518795 c.681C>A synonymous_variant 0.77 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.69 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.69 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.64 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.53 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.48 isoniazid
kasA 2518894 c.780G>A synonymous_variant 0.32 isoniazid
kasA 2519041 c.927C>T synonymous_variant 0.5 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.5 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.47 isoniazid
kasA 2519059 c.945G>C synonymous_variant 0.47 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.47 isoniazid
kasA 2519065 c.951C>T synonymous_variant 0.48 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.5 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.56 isoniazid
kasA 2519077 c.963G>C synonymous_variant 0.63 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.65 isoniazid
kasA 2519098 c.984C>A synonymous_variant 0.65 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.66 isoniazid
kasA 2519110 p.Asp332Glu missense_variant 0.66 isoniazid
kasA 2519111 c.997_999delCAGinsAC frameshift_variant&missense_variant 0.67 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.7 isoniazid
kasA 2519141 c.1027C>T synonymous_variant 0.69 isoniazid
kasA 2519146 c.1032C>T synonymous_variant 0.67 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.69 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.7 isoniazid
kasA 2519164 c.1050C>G synonymous_variant 0.68 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.68 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.67 isoniazid
kasA 2519185 c.1071C>G synonymous_variant 0.63 isoniazid
kasA 2519195 p.Thr361Ser missense_variant 0.66 isoniazid
kasA 2519221 c.1107G>A synonymous_variant 0.6 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.55 isoniazid
kasA 2519233 c.1119C>T synonymous_variant 0.5 isoniazid
kasA 2519234 c.1120_1122delGAGinsCC frameshift_variant&missense_variant 0.48 isoniazid
kasA 2519239 c.1125A>G synonymous_variant 0.48 isoniazid
kasA 2519242 c.1128C>A synonymous_variant 0.48 isoniazid
kasA 2519248 c.1134C>T synonymous_variant 0.48 isoniazid
kasA 2519251 c.1137G>A synonymous_variant 0.48 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.5 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 0.54 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.54 isoniazid
kasA 2519266 c.1152C>G synonymous_variant 0.54 isoniazid
kasA 2519275 c.1161C>T synonymous_variant 0.52 isoniazid
kasA 2519278 c.1164A>G synonymous_variant 0.52 isoniazid
kasA 2519281 c.1167G>T synonymous_variant 0.46 isoniazid
kasA 2519293 c.1179T>C synonymous_variant 0.47 isoniazid
kasA 2519298 p.Arg395Gln missense_variant 0.44 isoniazid
kasA 2519305 c.1191A>G synonymous_variant 0.44 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.42 isoniazid
kasA 2519332 c.1218C>G synonymous_variant 0.37 isoniazid
eis 2714846 p.Val163Ile missense_variant 0.75 amikacin Not assoc w R
kanamycin Not assoc w R
ahpC 2726576 p.Asp128Glu missense_variant 0.35 isoniazid
ahpC 2726582 c.390G>C synonymous_variant 0.42 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.56 isoniazid
ahpC 2726597 c.405C>G synonymous_variant 0.53 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.52 isoniazid
ahpC 2726636 c.444G>A synonymous_variant 0.6 isoniazid Not assoc w R - Interim
ahpC 2726638 p.Ala149Val missense_variant 0.58 isoniazid
ahpC 2726648 c.456T>C synonymous_variant 0.62 isoniazid
ahpC 2726657 c.465A>G synonymous_variant 0.62 isoniazid
ahpC 2726669 c.477T>C synonymous_variant 0.57 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.55 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.55 isoniazid
ahpC 2726714 c.522C>T synonymous_variant 0.47 isoniazid
ahpC 2726717 c.525A>C synonymous_variant 0.41 isoniazid
folC 2746438 c.1161G>C synonymous_variant 0.48 para-aminosalicylic_acid
folC 2746451 p.Gly383Ala missense_variant 0.49 para-aminosalicylic_acid
folC 2746464 p.Leu379Val missense_variant 0.51 para-aminosalicylic_acid
folC 2746477 c.1122T>C synonymous_variant 0.52 para-aminosalicylic_acid
folC 2746480 p.Arg373Gln missense_variant 0.5 para-aminosalicylic_acid
folC 2746495 c.1102_1104delCATinsGC frameshift_variant&missense_variant 0.51 para-aminosalicylic_acid
folC 2746498 c.1101G>C synonymous_variant 0.51 para-aminosalicylic_acid
folC 2746503 c.1096C>T synonymous_variant 0.51 para-aminosalicylic_acid
folC 2746504 c.1095G>T synonymous_variant 0.51 para-aminosalicylic_acid
folC 2746510 c.1089A>C synonymous_variant 0.51 para-aminosalicylic_acid
folC 2746516 c.1083T>G synonymous_variant 0.51 para-aminosalicylic_acid
folC 2746519 p.Ser360Ala missense_variant 0.51 para-aminosalicylic_acid
folC 2746531 c.1068G>C synonymous_variant 0.53 para-aminosalicylic_acid
folC 2746558 c.1041G>C synonymous_variant 0.5 para-aminosalicylic_acid
folC 2746561 c.1038C>G synonymous_variant 0.5 para-aminosalicylic_acid
folC 2746564 c.1035A>G synonymous_variant 0.52 para-aminosalicylic_acid
folC 2746579 c.1020G>A synonymous_variant 0.4 para-aminosalicylic_acid
folC 2747209 p.Leu130Phe missense_variant 0.3 para-aminosalicylic_acid
folC 2747220 p.Ile127Val missense_variant 0.48 para-aminosalicylic_acid
folC 2747224 c.375G>T synonymous_variant 0.47 para-aminosalicylic_acid
folC 2747260 p.Lys113Thr missense_variant 0.81 para-aminosalicylic_acid
folC 2747274 p.Ser109Ala missense_variant 0.86 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.86 para-aminosalicylic_acid
folC 2747281 c.318A>G synonymous_variant 0.79 para-aminosalicylic_acid
folC 2747284 c.313_315delGTGinsAC frameshift_variant&missense_variant 0.77 para-aminosalicylic_acid
folC 2747287 c.310_312delCCGinsGC frameshift_variant&missense_variant 0.77 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.77 para-aminosalicylic_acid
folC 2747299 c.300C>T synonymous_variant 0.78 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.81 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.83 para-aminosalicylic_acid
folC 2747341 c.256_258delGTCinsTG frameshift_variant&synonymous_variant 0.78 para-aminosalicylic_acid
folC 2747344 c.255G>T synonymous_variant 0.78 para-aminosalicylic_acid
folC 2747350 c.249C>T synonymous_variant 0.79 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.79 para-aminosalicylic_acid
folC 2747374 c.225G>A synonymous_variant 0.76 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.6 para-aminosalicylic_acid
folC 2747414 p.Arg62Leu missense_variant 0.66 para-aminosalicylic_acid
folC 2747419 c.180C>G synonymous_variant 0.65 para-aminosalicylic_acid
folC 2747422 c.177G>A synonymous_variant 0.68 para-aminosalicylic_acid
folC 2747428 c.171G>C synonymous_variant 0.72 para-aminosalicylic_acid
folC 2747455 c.144C>G synonymous_variant 0.42 para-aminosalicylic_acid
folC 2747460 c.139C>T synonymous_variant 0.38 para-aminosalicylic_acid
folC 2747464 c.135G>C synonymous_variant 0.35 para-aminosalicylic_acid
Rv2477c 2782528 c.1515G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783014 p.Ser343Thr missense_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783026 c.1017C>T synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.52 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783181 c.862C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>A synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783200 c.843G>A synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783239 p.Glu268Asp missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783248 c.795G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783310 c.733C>T synonymous_variant 0.57 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783341 c.702C>T synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>G synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>G synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.8 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783520 c.523T>C synonymous_variant 0.77 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783545 c.498C>G synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.88 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783634 p.Leu137Ile missense_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.84 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783645 p.Asp133Gly missense_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783650 c.393C>T synonymous_variant 0.85 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783656 c.387G>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.77 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783718 c.325T>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783755 c.286_288delATCinsCG frameshift_variant&missense_variant 0.6 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783758 p.Asp95Glu missense_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783764 c.277_279delATGinsCC frameshift_variant&missense_variant 0.6 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783767 c.276C>T synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783800 c.243G>A synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>T synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783872 c.171G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>A synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783950 c.93C>T synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>C synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 p.Tyr29Leu missense_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783959 c.84C>T synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783967 c.76T>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783986 c.57G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783989 c.54G>A synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784045 c.-3G>T upstream_gene_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784048 c.-6C>T upstream_gene_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784054 c.-12C>T upstream_gene_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859798 c.621G>C synonymous_variant 0.37 clofazimine
bedaquiline
pepQ 2859807 c.612C>T synonymous_variant 0.36 clofazimine
bedaquiline
pepQ 2859815 p.Ile202Val missense_variant 0.39 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.48 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
pepQ 2859843 c.576G>A synonymous_variant 0.53 clofazimine
bedaquiline
pepQ 2859852 c.567A>G synonymous_variant 0.56 clofazimine
bedaquiline
pepQ 2859855 p.Val188Ala missense_variant 0.53 clofazimine
bedaquiline
pepQ 2859858 p.Ala187Gly missense_variant 0.56 clofazimine
bedaquiline
pepQ 2859864 c.555T>C synonymous_variant 0.56 clofazimine
bedaquiline
pepQ 2859870 c.549T>C synonymous_variant 0.57 clofazimine
bedaquiline
pepQ 2859873 c.546T>C synonymous_variant 0.57 clofazimine
bedaquiline
pepQ 2859885 c.534C>G synonymous_variant 0.68 clofazimine
bedaquiline
pepQ 2859893 c.526C>T synonymous_variant 0.68 clofazimine
bedaquiline
pepQ 2859902 p.Ser173Gly missense_variant 0.68 clofazimine
bedaquiline
pepQ 2859909 c.510G>C synonymous_variant 0.69 clofazimine
bedaquiline
pepQ 2859933 c.486C>A synonymous_variant 0.58 clofazimine
bedaquiline
pepQ 2859942 p.Ala159Gln missense_variant 0.48 clofazimine
bedaquiline
pepQ 2859950 c.469T>C synonymous_variant 0.42 clofazimine
bedaquiline
pepQ 2859951 p.Asp156Glu missense_variant 0.43 clofazimine
bedaquiline
pepQ 2859966 c.453T>C synonymous_variant 0.41 clofazimine
bedaquiline
Rv2681 2996227 c.-512A>G upstream_gene_variant 0.27 capreomycin
Rv2681 2996236 c.-503C>G upstream_gene_variant 0.29 capreomycin
Rv2681 2996242 c.-497T>C upstream_gene_variant 0.34 capreomycin
Rv2681 2996248 c.-491A>G upstream_gene_variant 0.35 capreomycin
Rv2681 2996260 c.-479G>T upstream_gene_variant 0.43 capreomycin
Rv2681 2996263 c.-476A>C upstream_gene_variant 0.43 capreomycin
Rv2681 2996266 c.-473T>G upstream_gene_variant 0.43 capreomycin
Rv2681 2996278 c.-461T>C upstream_gene_variant 0.49 capreomycin
Rv2681 2996287 c.-452A>C upstream_gene_variant 0.52 capreomycin
Rv2680 2996294 p.Ile64Val missense_variant 0.5 capreomycin
Rv2680 2996308 p.Glu68Asp missense_variant 0.49 capreomycin
Rv2680 2996309 p.Leu69Val missense_variant 0.49 capreomycin
Rv2680 2996310 c.206_207insTG frameshift_variant 0.49 capreomycin Uncertain significance
Rv2680 2996313 c.209_210insT frameshift_variant 0.46 capreomycin Uncertain significance
Rv2680 2996317 c.214_216delATT conservative_inframe_deletion 0.5 capreomycin
Rv2680 2996329 c.225T>C synonymous_variant 0.59 capreomycin Not assoc w R - Interim
Rv2681 2996338 c.-401C>T upstream_gene_variant 0.6 capreomycin
Rv2681 2996359 c.-380C>T upstream_gene_variant 0.6 capreomycin
Rv2680 2996360 p.Met86Leu missense_variant 0.59 capreomycin
Rv2681 2996374 c.-365G>T upstream_gene_variant 0.56 capreomycin
Rv2680 2996381 p.Ser93Ala missense_variant 0.55 capreomycin
Rv2680 2996386 c.282T>C synonymous_variant 0.52 capreomycin Not assoc w R - Interim
Rv2681 2996389 c.-350A>C upstream_gene_variant 0.5 capreomycin
Rv2681 2996401 c.-338T>C upstream_gene_variant 0.44 capreomycin
Rv2680 2996404 p.Ile100Met missense_variant 0.39 capreomycin
Rv2681 2996407 c.-332C>G upstream_gene_variant 0.38 capreomycin
Rv2681 2996419 c.-320T>C upstream_gene_variant 0.29 capreomycin
Rv2680 2996420 p.Val106Ile missense_variant 0.3 capreomycin
Rv2681 2996440 c.-299G>C upstream_gene_variant 0.33 capreomycin
Rv2681 2996443 c.-296T>C upstream_gene_variant 0.34 capreomycin
Rv2680 2996446 c.342A>G synonymous_variant 0.34 capreomycin Not assoc w R - Interim
Rv2680 2996450 p.Val116Ile missense_variant 0.33 capreomycin
Rv2681 2996458 c.-281C>G upstream_gene_variant 0.33 capreomycin
Rv2681 2996459 c.-280C>T upstream_gene_variant 0.33 capreomycin
Rv2681 2996470 c.-269G>A upstream_gene_variant 0.31 capreomycin
Rv2752c 3064860 c.1332G>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064863 c.1329G>A synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064872 c.1320T>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3064877 p.Ser439Ala missense_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064881 p.Ser437Ala missense_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064899 c.1293G>T synonymous_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064911 c.1281C>G synonymous_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064932 c.1260T>C synonymous_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064935 c.1257A>G synonymous_variant 0.55 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064941 c.1249_1251delCAAinsGG frameshift_variant&missense_variant 0.52 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064944 c.1248G>C synonymous_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064947 c.1245A>C synonymous_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064950 c.1242C>A synonymous_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.52 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064959 c.1233C>G synonymous_variant 0.5 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064969 p.Lys408Ala missense_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.49 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065004 c.1188G>A synonymous_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065016 c.1174_1176delAACinsCG frameshift_variant&missense_variant 0.44 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065022 c.1170G>C synonymous_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065403 c.789C>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065418 c.774A>G synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065430 c.762A>C synonymous_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065436 c.756A>G synonymous_variant 0.48 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065439 c.753C>G synonymous_variant 0.48 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065457 c.735A>G synonymous_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065463 c.729T>C synonymous_variant 0.6 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065487 c.705T>C synonymous_variant 0.61 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065490 c.702A>C synonymous_variant 0.54 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065499 c.693A>C synonymous_variant 0.5 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065502 p.Asp230Glu missense_variant 0.49 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065511 c.681G>C synonymous_variant 0.49 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065517 c.673_675delCTCinsTG frameshift_variant&synonymous_variant 0.48 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065532 c.660A>G synonymous_variant 0.46 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065538 c.654G>C synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065541 c.651A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065550 c.642G>A synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065553 c.639A>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065562 c.630T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065568 c.624C>T synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065571 c.621G>A synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065574 c.618C>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065580 c.612G>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065589 c.603C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065892 c.300C>T synonymous_variant 0.46 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065901 c.291A>T synonymous_variant 0.46 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065905 p.Leu96Gln missense_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065913 c.279G>A synonymous_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 c.276T>C synonymous_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065922 c.270T>C synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065925 c.267G>A synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065928 c.264G>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065940 c.252G>A synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065947 p.Gly82Ala missense_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065957 c.235T>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065972 p.Ile74Val missense_variant 0.54 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.62 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065982 c.210G>A synonymous_variant 0.63 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065985 c.207C>T synonymous_variant 0.63 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065993 p.Val67Ile missense_variant 0.62 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065997 c.195C>G synonymous_variant 0.62 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.6 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066006 c.186G>T synonymous_variant 0.59 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.47 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 p.Gly56Ala missense_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066051 c.141G>C synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066081 c.111G>C synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066084 c.108C>T synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066096 c.96G>T synonymous_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067325 c.621A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067331 c.615C>T synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067354 p.Met198Val missense_variant 0.8 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067360 p.Ile196Val missense_variant 0.81 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.76 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.81 para-aminosalicylic_acid
thyX 3067409 c.537C>G synonymous_variant 0.77 para-aminosalicylic_acid
thyX 3067416 p.Asn177Ser missense_variant 0.8 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.75 para-aminosalicylic_acid
thyX 3067442 c.504C>G synonymous_variant 0.7 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGT frameshift_variant&missense_variant 0.61 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067469 c.477C>T synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067481 c.465C>T synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067484 c.462C>T synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067511 c.435G>A synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.59 para-aminosalicylic_acid
thyX 3067526 c.420C>A synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067679 c.267C>T synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067709 c.237G>C synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.54 para-aminosalicylic_acid
thyX 3067766 c.180C>T synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067802 c.144C>A synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067840 p.Val36Ile missense_variant 0.59 para-aminosalicylic_acid
thyX 3067844 c.102G>A synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067847 p.Pro33Gln missense_variant 0.58 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.65 para-aminosalicylic_acid
thyX 3067874 c.72C>A synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.66 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.64 para-aminosalicylic_acid
thyX 3067915 c.31C>T synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067918 p.Gln10Glu missense_variant 0.54 para-aminosalicylic_acid
thyX 3067934 c.12C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067956 c.-11A>G upstream_gene_variant 0.25 para-aminosalicylic_acid
thyA 3073860 c.612C>T synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073874 p.Ile200Val missense_variant 0.36 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073887 c.583_585delTCGinsGC frameshift_variant&missense_variant 0.38 para-aminosalicylic_acid
thyA 3073893 c.578_579insT frameshift_variant 0.38 para-aminosalicylic_acid
thyA 3073920 c.552C>A synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3073934 p.Ser180Gly missense_variant 0.47 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.55 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073997 c.475delCinsAAAT conservative_inframe_insertion&synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074008 p.Ala155Val missense_variant 0.31 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074013 c.459C>T synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3074025 p.Phe149Leu missense_variant 0.49 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074042 p.Pro144Ala missense_variant 0.5 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.49 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.49 para-aminosalicylic_acid
thyA 3074061 p.Glu137Asp missense_variant 0.5 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3074103 c.369C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3074120 p.Leu118Met missense_variant 0.44 para-aminosalicylic_acid
thyA 3074121 p.Asp117Glu missense_variant 0.45 para-aminosalicylic_acid
thyA 3074160 c.312A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074244 c.228A>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074256 c.216G>A synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3074262 p.Gly70Ala missense_variant 0.53 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.55 para-aminosalicylic_acid
thyA 3074285 c.187T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3074298 c.174G>A synonymous_variant 0.57 para-aminosalicylic_acid
thyA 3074305 p.Ala56Ile missense_variant 0.56 para-aminosalicylic_acid
thyA 3074307 c.165A>G synonymous_variant 0.57 para-aminosalicylic_acid
thyA 3074313 c.159A>G synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3074319 c.153T>C synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3074322 c.150C>G synonymous_variant 0.57 para-aminosalicylic_acid
thyA 3074325 c.147A>G synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3074328 c.144G>A synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3074334 c.138T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3074339 p.Leu45Ile missense_variant 0.62 para-aminosalicylic_acid
thyA 3074355 c.117G>A synonymous_variant 0.64 para-aminosalicylic_acid
thyA 3074360 c.112T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3074361 c.111T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3074364 c.108T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3074376 p.Gln32His missense_variant 0.48 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624614 c.297A>C synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624617 c.294C>A synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624632 c.279G>C synonymous_variant 0.61 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 0.62 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.62 bedaquiline
rifampicin
lpqB 3624653 c.258C>T synonymous_variant 0.65 bedaquiline
rifampicin
lpqB 3624671 c.240C>A synonymous_variant 0.66 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.72 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.75 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>G synonymous_variant 0.81 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.81 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.84 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.83 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.83 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.84 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.85 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.79 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.72 bedaquiline
rifampicin
lpqB 3624779 c.132G>C synonymous_variant 0.7 bedaquiline
rifampicin
lpqB 3624783 p.Ser43Ala missense_variant 0.67 bedaquiline
rifampicin
lpqB 3624788 c.123A>G synonymous_variant 0.64 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624797 c.114T>C synonymous_variant 0.59 bedaquiline
rifampicin
lpqB 3624807 p.Val35Ala missense_variant 0.48 bedaquiline
rifampicin
lpqB 3624811 p.Pro34Thr missense_variant 0.45 bedaquiline
rifampicin
lpqB 3624812 c.99T>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624815 c.96A>G synonymous_variant 0.45 bedaquiline
rifampicin
lpqB 3624824 c.87A>C synonymous_variant 0.43 bedaquiline
rifampicin
lpqB 3624833 c.78A>G synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3625045 c.-135C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625090 c.1524C>T synonymous_variant 0.58 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625095 p.Glu507Lys missense_variant 0.58 bedaquiline
rifampicin
lpqB 3625099 c.-189C>G upstream_gene_variant 0.62 bedaquiline
rifampicin
lpqB 3625111 c.-201G>C upstream_gene_variant 0.65 bedaquiline
rifampicin
lpqB 3625114 c.-204G>A upstream_gene_variant 0.63 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.7 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.78 bedaquiline
rifampicin
lpqB 3625135 c.-225A>T upstream_gene_variant 0.76 bedaquiline
rifampicin
lpqB 3625138 c.-228C>G upstream_gene_variant 0.78 bedaquiline
rifampicin
lpqB 3625150 c.-240C>T upstream_gene_variant 0.79 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.81 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625174 c.-264C>G upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrB 3625183 c.1429_1431delCGGinsAA frameshift_variant&missense_variant 0.77 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625186 c.-276T>C upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.77 bedaquiline
rifampicin
lpqB 3625198 c.-288C>A upstream_gene_variant 0.75 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625234 c.-324G>A upstream_gene_variant 0.76 bedaquiline
rifampicin
lpqB 3625243 c.-333T>G upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625258 c.-348G>A upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.66 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625273 c.-363C>G upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625276 c.-366C>T upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625282 c.-372C>G upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625510 c.-600T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625555 c.-645G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625558 c.-648C>T upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.59 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625576 c.-666C>T upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3625591 p.Ser341Asn missense_variant 0.59 bedaquiline
rifampicin
lpqB 3625594 c.-684T>G upstream_gene_variant 0.59 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625603 c.-693G>A upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625609 c.-699C>A upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625612 c.-702G>T upstream_gene_variant 0.62 bedaquiline
rifampicin
lpqB 3625615 c.-705G>A upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ala missense_variant 0.63 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.65 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.66 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.74 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.76 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625660 c.954C>T synonymous_variant 0.76 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.76 bedaquiline
rifampicin
lpqB 3625678 c.-768C>G upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrB 3625708 c.906C>T synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.78 bedaquiline
rifampicin
mtrB 3625744 c.870G>A synonymous_variant 0.78 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625762 c.852A>G synonymous_variant 0.81 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625819 c.795G>A synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.7 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.7 bedaquiline
rifampicin
lpqB 3625852 c.-942A>C upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3625855 c.759G>A synonymous_variant 0.68 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3625873 c.741C>T synonymous_variant 0.72 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625876 c.738G>C synonymous_variant 0.7 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625894 c.-984G>C upstream_gene_variant 0.74 bedaquiline
rifampicin
lpqB 3625897 c.-987G>T upstream_gene_variant 0.7 bedaquiline
rifampicin
lpqB 3625909 c.-999T>G upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3625923 c.691C>T synonymous_variant 0.47 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626684 c.-71G>A upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626705 c.-92G>C upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3626708 c.-95G>T upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3626720 c.-107G>A upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3626753 c.-140G>A upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.66 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrA 3626792 c.558G>T synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626843 c.-230G>A upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.78 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.82 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.83 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.77 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.81 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.78 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3626959 c.-346C>T upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.74 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.71 bedaquiline
rifampicin Uncertain significance
mtrB 3626987 c.-374C>G upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3627067 c.-454C>T upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.65 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 0.67 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3627077 c.-464G>C upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.7 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.64 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627131 c.-518C>G upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.55 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627149 c.-536G>A upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.56 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627218 c.-605G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627224 c.-611G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.74 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627251 c.-638G>A upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627275 c.-662G>A upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.74 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrA 3627323 c.25_27delTTGinsCC frameshift_variant&missense_variant 0.7 bedaquiline
rifampicin
fbiA 3640701 p.Ile53Met missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3640707 c.-828G>C upstream_gene_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3640713 c.-822T>C upstream_gene_variant 0.28 clofazimine
pretomanid
delamanid
fbiA 3640714 p.Val58Ile missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3640725 c.-810T>C upstream_gene_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3640743 c.-792T>C upstream_gene_variant 0.46 clofazimine
pretomanid
delamanid
fbiB 3640747 c.-788C>T upstream_gene_variant 0.55 clofazimine
pretomanid
delamanid
fbiB 3640758 c.-777G>C upstream_gene_variant 0.63 clofazimine
pretomanid
delamanid
fbiB 3640761 c.-774G>C upstream_gene_variant 0.65 clofazimine
pretomanid
delamanid
fbiB 3640782 c.-753C>T upstream_gene_variant 0.69 clofazimine
pretomanid
delamanid
fbiA 3640785 p.Gln81His missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiB 3640788 c.-747T>C upstream_gene_variant 0.7 clofazimine
pretomanid
delamanid
fbiB 3640797 c.-738T>C upstream_gene_variant 0.64 clofazimine
pretomanid
delamanid
fbiA 3640808 p.Met89Lys missense_variant 0.58 clofazimine
pretomanid
delamanid
fbiA 3640810 p.Gln90Glu missense_variant 0.6 clofazimine
pretomanid
delamanid
fbiB 3640827 c.-708T>C upstream_gene_variant 0.57 clofazimine
pretomanid
delamanid
fbiB 3640839 c.-696C>G upstream_gene_variant 0.53 clofazimine
pretomanid
delamanid
fbiB 3640857 c.-678G>T upstream_gene_variant 0.49 clofazimine
pretomanid
delamanid
fbiB 3640867 c.-668C>T upstream_gene_variant 0.47 clofazimine
pretomanid
delamanid
fbiB 3640872 c.-663C>G upstream_gene_variant 0.48 clofazimine
pretomanid
delamanid
fbiB 3640878 c.-657T>C upstream_gene_variant 0.38 clofazimine
pretomanid
delamanid
fbiA 3640901 p.Gln120Arg missense_variant 0.34 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiB 3642602 c.1068A>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiB 3642626 c.1092C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiB 3642634 p.Asp367Gly missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiB 3642643 p.His370Arg missense_variant 0.55 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiB 3642647 c.1113C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiB 3642665 c.1131C>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiB 3642674 c.1140C>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiB 3642682 p.Ala383Gly missense_variant 0.68 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiB 3642695 c.1161G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiB 3642696 c.1162C>T synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiB 3642704 c.1170G>T synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
rpoA 3877524 c.984C>A synonymous_variant 0.42 rifampicin
rpoA 3877545 c.963G>C synonymous_variant 0.48 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.57 rifampicin
rpoA 3877575 c.933C>T synonymous_variant 0.58 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877598 c.910C>T synonymous_variant 0.72 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.77 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.79 rifampicin
rpoA 3877650 c.858C>T synonymous_variant 0.77 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.76 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.75 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.75 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877685 c.823C>T synonymous_variant 0.75 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877707 c.801G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.8 rifampicin
rpoA 3877742 c.766C>T synonymous_variant 0.79 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877748 c.760C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.82 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.8 rifampicin
rpoA 3877842 c.666A>C synonymous_variant 0.8 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>G synonymous_variant 0.8 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.82 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877886 c.622C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.88 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877956 c.552G>A synonymous_variant 0.85 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3877983 c.525C>T synonymous_variant 0.84 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.82 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>T synonymous_variant 0.85 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3878025 c.483C>T synonymous_variant 0.88 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.88 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.88 rifampicin
rpoA 3878037 c.471C>T synonymous_variant 0.87 rifampicin
rpoA 3878046 c.462T>G synonymous_variant 0.81 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.81 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.8 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.81 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.81 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.79 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.78 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.77 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.76 rifampicin
rpoA 3878109 c.399G>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.78 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.76 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.74 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.72 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.71 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.83 rifampicin
rpoA 3878229 c.279C>G synonymous_variant 0.83 rifampicin
rpoA 3878241 c.267G>A synonymous_variant 0.85 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.86 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.79 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878358 c.150C>G synonymous_variant 0.73 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.69 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.67 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.6 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.59 rifampicin
rpoA 3878672 c.-165A>T upstream_gene_variant 1.0 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.95 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.9 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.91 rifampicin
rpoA 3878728 c.-221G>A upstream_gene_variant 0.91 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.92 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.89 rifampicin
rpoA 3878749 c.-242G>T upstream_gene_variant 0.88 rifampicin
rpoA 3878752 c.-245G>A upstream_gene_variant 0.85 rifampicin
rpoA 3878755 c.-248G>A upstream_gene_variant 0.85 rifampicin
rpoA 3878758 c.-251G>C upstream_gene_variant 0.85 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.82 rifampicin
rpoA 3878776 c.-269G>C upstream_gene_variant 0.82 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.85 rifampicin Uncertain significance
rpoA 3878794 c.-287G>C upstream_gene_variant 0.84 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.84 rifampicin
rpoA 3878800 c.-293G>A upstream_gene_variant 0.84 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.84 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.84 rifampicin
rpoA 3878823 c.-316G>C upstream_gene_variant 0.84 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.82 rifampicin
rpoA 3878842 c.-337_-335delCGGinsAAA upstream_gene_variant 0.8 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.8 rifampicin Uncertain significance
rpoA 3878881 c.-374C>G upstream_gene_variant 0.77 rifampicin
rpoA 3878884 c.-377C>G upstream_gene_variant 0.74 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.74 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.74 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.71 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.72 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.71 rifampicin
rpoA 3878920 c.-413C>T upstream_gene_variant 0.7 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.63 rifampicin
rpoA 3878947 c.-440G>T upstream_gene_variant 0.61 rifampicin
rpoA 3878953 c.-446C>G upstream_gene_variant 0.59 rifampicin
rpoA 3878956 c.-449G>A upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3879073 c.-566A>G upstream_gene_variant 0.76 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.76 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.77 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.79 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.82 rifampicin
rpoA 3879125 c.-618T>G upstream_gene_variant 0.82 rifampicin
rpoA 3879127 c.-621_-620delATinsTC upstream_gene_variant 0.82 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.85 rifampicin
rpoA 3879157 c.-650C>T upstream_gene_variant 0.84 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.84 rifampicin
rpoA 3879166 c.-659C>T upstream_gene_variant 0.81 rifampicin
rpoA 3879184 c.-677G>A upstream_gene_variant 0.81 rifampicin
rpoA 3879190 c.-683C>A upstream_gene_variant 0.84 rifampicin
rpoA 3879199 c.-692C>T upstream_gene_variant 0.83 rifampicin
rpoA 3879208 c.-701C>G upstream_gene_variant 0.78 rifampicin
rpoA 3879215 c.-709_-708delACinsGT upstream_gene_variant 0.7 rifampicin
rpoA 3879219 c.-712C>G upstream_gene_variant 0.68 rifampicin
rpoA 3879220 c.-713G>A upstream_gene_variant 0.68 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.68 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.68 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.68 rifampicin
rpoA 3879235 c.-728C>T upstream_gene_variant 0.68 rifampicin
ddn 3986622 c.-222C>T upstream_gene_variant 0.82 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.79 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.76 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.74 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.66 delamanid
pretomanid
ddn 3986681 c.-163C>A upstream_gene_variant 0.62 delamanid
pretomanid
ddn 3986690 c.-154C>T upstream_gene_variant 0.55 delamanid
pretomanid
ddn 3986696 c.-148G>C upstream_gene_variant 0.52 delamanid
pretomanid
ddn 3986705 c.-139C>G upstream_gene_variant 0.38 delamanid
pretomanid
clpC1 4038209 c.2496G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038217 p.Pro830Ala missense_variant 0.43 pyrazinamide
clpC1 4038226 c.2478_2479insGCCGAG conservative_inframe_insertion 0.56 pyrazinamide
clpC1 4038234 p.Arg824His missense_variant 0.78 pyrazinamide
clpC1 4038238 p.Thr823Ala missense_variant 0.78 pyrazinamide
clpC1 4038257 c.2448G>T synonymous_variant 0.87 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.89 pyrazinamide
clpC1 4038272 c.2433T>C synonymous_variant 0.89 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.89 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.86 pyrazinamide
clpC1 4038314 c.2391T>A synonymous_variant 0.86 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.87 pyrazinamide
clpC1 4038325 p.Val794Ile missense_variant 0.87 pyrazinamide
clpC1 4038329 c.2376G>A synonymous_variant 0.86 pyrazinamide
clpC1 4038335 c.2370C>G synonymous_variant 0.87 pyrazinamide
clpC1 4038353 c.2352G>A synonymous_variant 0.9 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.89 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.87 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.86 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.83 pyrazinamide
clpC1 4038380 c.2325C>A synonymous_variant 0.76 pyrazinamide
clpC1 4038383 c.2322G>C synonymous_variant 0.74 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.71 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.67 pyrazinamide
clpC1 4038395 c.2310C>G synonymous_variant 0.67 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.61 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4038410 c.2295C>T synonymous_variant 0.61 pyrazinamide
clpC1 4038419 c.2286T>G synonymous_variant 0.64 pyrazinamide
clpC1 4038436 p.Ala757Ser missense_variant 0.62 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.55 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.65 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.65 pyrazinamide
clpC1 4038474 p.Ser744Thr missense_variant 0.67 pyrazinamide
clpC1 4038485 p.Gly740Lys missense_variant 0.63 pyrazinamide
clpC1 4038488 p.Ala739Glu missense_variant 0.63 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.7 pyrazinamide
clpC1 4038502 p.Ile735Val missense_variant 0.71 pyrazinamide
clpC1 4038520 c.2185C>A synonymous_variant 0.8 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.88 pyrazinamide
clpC1 4038533 c.2172C>T synonymous_variant 0.88 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4038554 c.2151C>T synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4038623 c.2082A>G synonymous_variant 0.93 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.88 pyrazinamide
clpC1 4038650 c.2055C>G synonymous_variant 0.9 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.9 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.89 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.9 pyrazinamide
clpC1 4038680 c.2025G>A synonymous_variant 0.9 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4038686 c.2019C>T synonymous_variant 0.88 pyrazinamide
clpC1 4038694 p.Ser671Ala missense_variant 0.89 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.92 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.86 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.83 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.84 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.86 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.83 pyrazinamide
clpC1 4038863 c.1842G>C synonymous_variant 0.83 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>T synonymous_variant 0.86 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.87 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.85 pyrazinamide
clpC1 4038950 c.1755C>T synonymous_variant 0.82 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.81 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4038997 c.1708T>C synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>T synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.79 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.77 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.7 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.69 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.76 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.66 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039154 c.1551G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039163 c.1540_1542delCTGinsAC frameshift_variant&missense_variant 0.63 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.61 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.63 pyrazinamide
clpC1 4039178 c.1527G>T synonymous_variant 0.66 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.65 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.75 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.76 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.78 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>G synonymous_variant 0.8 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.8 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.79 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.79 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.81 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.81 pyrazinamide
clpC1 4039385 c.1320C>T synonymous_variant 0.81 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.81 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.8 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.79 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.81 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039439 c.1266C>T synonymous_variant 0.77 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.77 pyrazinamide
clpC1 4039448 c.1257A>T synonymous_variant 0.78 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.76 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039481 c.1224T>A synonymous_variant 0.81 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.82 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.84 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.84 pyrazinamide Uncertain significance
clpC1 4039574 c.1129_1131delGCGinsTC frameshift_variant&missense_variant 0.83 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4039582 p.Thr375Ser missense_variant 0.84 pyrazinamide
clpC1 4039604 c.1101G>A synonymous_variant 0.89 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.9 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.87 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039670 c.1035G>A synonymous_variant 0.86 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.82 pyrazinamide
clpC1 4039688 c.1017G>A synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039694 c.1011G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4039715 c.990G>A synonymous_variant 0.86 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039754 c.951G>A synonymous_variant 0.82 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.86 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039805 c.900C>G synonymous_variant 0.87 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.88 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.87 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039880 c.825G>A synonymous_variant 0.81 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.78 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>T synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.8 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.74 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.69 pyrazinamide
clpC1 4040010 p.Ala232Asn missense_variant 0.69 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.71 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.72 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.73 pyrazinamide
clpC1 4040084 c.621C>T synonymous_variant 0.77 pyrazinamide
clpC1 4040087 c.618G>T synonymous_variant 0.72 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.76 pyrazinamide
clpC1 4040129 c.576C>T synonymous_variant 0.79 pyrazinamide
clpC1 4040138 c.567G>C synonymous_variant 0.81 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.82 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.84 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.85 pyrazinamide
clpC1 4040180 c.525C>T synonymous_variant 0.86 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.85 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.87 pyrazinamide
clpC1 4040213 c.492T>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040228 c.477G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.84 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.85 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.82 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.76 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.75 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040324 c.381G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.66 pyrazinamide
clpC1 4040351 c.354C>T synonymous_variant 0.62 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.62 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.62 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.61 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.6 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.6 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.62 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.62 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>G synonymous_variant 0.55 pyrazinamide
clpC1 4040426 c.279T>G synonymous_variant 0.49 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.49 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.49 pyrazinamide
clpC1 4040435 c.270G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.51 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.54 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.53 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.5 pyrazinamide
clpC1 4040519 c.186G>A synonymous_variant 0.49 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.5 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.46 pyrazinamide
clpC1 4040560 c.145C>T synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.51 pyrazinamide
clpC1 4040567 c.138C>T synonymous_variant 0.53 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040576 c.129C>T synonymous_variant 0.53 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040588 c.117T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.5 pyrazinamide
clpC1 4040597 c.108C>A synonymous_variant 0.57 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.57 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.53 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.49 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.52 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.42 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
panD 4044015 c.267G>C synonymous_variant 0.38 pyrazinamide
panD 4044018 c.264T>C synonymous_variant 0.38 pyrazinamide
panD 4044024 c.258T>C synonymous_variant 0.43 pyrazinamide
panD 4044033 c.249T>C synonymous_variant 0.46 pyrazinamide
panD 4044036 c.246G>T synonymous_variant 0.44 pyrazinamide
panD 4044039 c.243G>C synonymous_variant 0.46 pyrazinamide
panD 4044045 c.237G>T synonymous_variant 0.46 pyrazinamide
panD 4044050 c.232T>C synonymous_variant 0.46 pyrazinamide
panD 4044051 c.231C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
panD 4044057 c.225C>G synonymous_variant 0.5 pyrazinamide
panD 4044063 c.219T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
panD 4044072 c.210C>A synonymous_variant 0.58 pyrazinamide
panD 4044075 c.207T>C synonymous_variant 0.63 pyrazinamide
panD 4044096 c.186C>T synonymous_variant 0.65 pyrazinamide
panD 4044105 c.177G>C synonymous_variant 0.65 pyrazinamide
panD 4044117 c.165G>C synonymous_variant 0.67 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.65 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.65 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.65 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>G synonymous_variant 0.63 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.59 pyrazinamide
panD 4044170 c.112C>T synonymous_variant 0.62 pyrazinamide
panD 4044177 c.105C>G synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
panD 4044188 c.94T>C synonymous_variant 0.6 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.6 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.6 pyrazinamide
panD 4044210 c.72C>T synonymous_variant 0.56 pyrazinamide
glpK 4138421 c.1335G>T synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138427 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.52 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138464 p.Gly431Ala missense_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138469 c.1287C>T synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>T synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138475 c.1281C>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138481 c.1275G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138484 c.1272G>A synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138487 c.1267_1269delTTGinsCC frameshift_variant&missense_variant 0.5 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138490 c.1266G>T synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138505 c.1251T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138514 c.1242A>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138518 p.Glu413Ala missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138532 c.1224G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138558 p.Ala400Ser missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138559 c.1197G>A synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>A synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138596 p.Phe387Tyr missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>T synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.57 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138640 c.1116C>T synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.61 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138646 c.1110G>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.63 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>C synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>T synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138681 p.Met359Val missense_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>T synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138781 c.975G>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139545 c.211T>C synonymous_variant 0.7 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139552 c.204G>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.75 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139582 c.174C>T synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139588 c.168G>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139600 c.156G>A synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139608 c.148C>T synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139618 c.138C>T synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139624 c.132C>T synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139637 p.Ala40Gly missense_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139647 p.Ala37Ser missense_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139648 c.108T>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139653 p.His35Asp missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139657 c.99T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139663 c.93C>T synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239336 c.-527T>C upstream_gene_variant 0.36 ethambutol
embC 4239348 c.-515_-513delCTGinsAC upstream_gene_variant 0.37 ethambutol
embC 4239377 c.-486C>G upstream_gene_variant 0.37 ethambutol
embC 4239378 c.-485T>C upstream_gene_variant 0.37 ethambutol
embC 4239386 c.-477G>C upstream_gene_variant 0.31 ethambutol
embC 4239986 p.Val42Leu missense_variant 0.22 ethambutol Uncertain significance
embC 4239994 c.132C>G synonymous_variant 0.34 ethambutol
embC 4240021 p.Asn53Lys missense_variant 0.34 ethambutol Uncertain significance
embC 4240033 c.171G>C synonymous_variant 0.38 ethambutol
embC 4240034 c.172_174delCAAinsGG frameshift_variant&missense_variant 0.38 ethambutol
embC 4240048 c.186C>G synonymous_variant 0.38 ethambutol
embC 4240058 p.Thr66Val missense_variant 0.39 ethambutol
embC 4240061 c.199_201delTTCinsCG frameshift_variant&missense_variant 0.39 ethambutol
embC 4240065 p.Ala68Gly missense_variant 0.37 ethambutol
embC 4240075 p.Glu71Asp missense_variant 0.37 ethambutol
embC 4240087 c.225T>C synonymous_variant 0.35 ethambutol
embC 4240106 c.244T>C synonymous_variant 0.35 ethambutol
embC 4240110 p.Asn83Thr missense_variant 0.35 ethambutol
embC 4240118 c.256_258delGTCinsAT frameshift_variant&missense_variant 0.36 ethambutol
embC 4240703 c.841C>T synonymous_variant 0.6 ethambutol
embC 4240717 c.855T>C synonymous_variant 0.67 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.69 ethambutol Not assoc w R - Interim
embC 4240736 p.Ser292Ala missense_variant 0.7 ethambutol
embC 4240771 c.909G>T synonymous_variant 0.8 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.8 ethambutol
embC 4240786 c.924C>A synonymous_variant 0.77 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.79 ethambutol
embC 4240795 c.933C>G synonymous_variant 0.8 ethambutol
embC 4240807 c.945C>G synonymous_variant 0.8 ethambutol Not assoc w R - Interim
embC 4240819 c.957A>G synonymous_variant 0.81 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.81 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.81 ethambutol
embC 4240843 c.981C>T synonymous_variant 0.81 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.81 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.8 ethambutol
embC 4240875 p.Ser338Thr missense_variant 0.81 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.76 ethambutol
embC 4240897 c.1035C>A synonymous_variant 0.74 ethambutol
embC 4240900 c.1038A>G synonymous_variant 0.7 ethambutol
embC 4240906 c.1044C>G synonymous_variant 0.67 ethambutol
embC 4240910 p.Ala350Leu missense_variant 0.66 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.54 ethambutol
embC 4240922 p.Thr354Ala missense_variant 0.52 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.48 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.34 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.34 ethambutol
embC 4241047 c.1185C>T synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embC 4241050 c.1188T>G synonymous_variant 0.47 ethambutol
embC 4241056 c.1194C>A synonymous_variant 0.47 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.52 ethambutol
embC 4241101 c.1239G>C synonymous_variant 0.59 ethambutol
embC 4241110 c.1248G>A synonymous_variant 0.59 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.56 ethambutol
embC 4241140 c.1278A>C synonymous_variant 0.54 ethambutol
embC 4241141 p.Ile427Val missense_variant 0.54 ethambutol Uncertain significance
embC 4241153 c.1291_1293delATCinsCT frameshift_variant&missense_variant 0.56 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.54 ethambutol
embC 4241162 c.1300T>C synonymous_variant 0.5 ethambutol
embC 4241179 c.1317G>C synonymous_variant 0.52 ethambutol
embC 4242229 c.2367C>T synonymous_variant 0.33 ethambutol
embC 4242232 c.2370T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4242245 p.Thr795Ser missense_variant 0.58 ethambutol
embA 4242268 c.-965T>C upstream_gene_variant 0.77 ethambutol
embA 4242271 c.-962A>C upstream_gene_variant 0.74 ethambutol
embC 4242273 p.Gly804Ala missense_variant 0.74 ethambutol
embA 4242277 c.-956T>C upstream_gene_variant 0.77 ethambutol
embC 4242283 c.2421T>C synonymous_variant 0.78 ethambutol Not assoc w R - Interim
embC 4242287 p.Leu809Val missense_variant 0.78 ethambutol
embC 4242291 p.Asn810Ser missense_variant 0.78 ethambutol
embC 4242302 p.Leu814Met missense_variant 0.78 ethambutol
embC 4242311 p.Gly817Ser missense_variant 0.75 ethambutol
embA 4242319 c.-914A>G upstream_gene_variant 0.75 ethambutol
embC 4242320 p.Pro820Ala missense_variant 0.75 ethambutol
embA 4242334 c.-899G>C upstream_gene_variant 0.7 ethambutol
embA 4242340 c.-893C>A upstream_gene_variant 0.71 ethambutol
embA 4242343 c.-890G>C upstream_gene_variant 0.7 ethambutol
embA 4242349 c.-884A>G upstream_gene_variant 0.73 ethambutol
embA 4242364 c.-869C>A upstream_gene_variant 0.68 ethambutol
embA 4242367 c.-866C>A upstream_gene_variant 0.64 ethambutol
embA 4242373 c.-860C>G upstream_gene_variant 0.65 ethambutol
embA 4242376 c.-857G>C upstream_gene_variant 0.65 ethambutol
embA 4242382 c.-851C>G upstream_gene_variant 0.65 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.83 ethambutol Not assoc w R
embA 4245092 c.1860C>G synonymous_variant 0.4 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.56 ethambutol
embA 4245110 c.1878C>T synonymous_variant 0.65 ethambutol
embA 4245116 c.1884C>T synonymous_variant 0.71 ethambutol
embA 4245136 p.Tyr635Phe missense_variant 0.75 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.75 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.77 ethambutol
embA 4245152 c.1920C>G synonymous_variant 0.77 ethambutol
embA 4245164 c.1932C>T synonymous_variant 0.75 ethambutol
embA 4245183 c.1951C>T synonymous_variant 0.76 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.79 ethambutol
embA 4245191 c.1959G>C synonymous_variant 0.79 ethambutol
embA 4245198 c.1966_1968delCTCinsGG frameshift_variant&missense_variant 0.84 ethambutol Uncertain significance
embA 4245206 c.1974A>G synonymous_variant 0.81 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.81 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.84 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.78 ethambutol Uncertain significance
embA 4245234 p.Met668Leu missense_variant 0.76 ethambutol
embA 4245242 c.2010C>T synonymous_variant 0.76 ethambutol Not assoc w R - Interim
embA 4245257 c.2025A>G synonymous_variant 0.58 ethambutol
embA 4245264 p.Asp678Pro missense_variant 0.44 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.38 ethambutol
embB 4248041 p.Ala510Ser missense_variant 0.37 ethambutol
embB 4248044 c.1531_1533delAAAinsGC frameshift_variant&missense_variant 0.37 ethambutol
embB 4248052 c.1539G>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>C synonymous_variant 0.4 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4248076 c.1563G>A synonymous_variant 0.49 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.5 ethambutol
embB 4248094 c.1581C>T synonymous_variant 0.46 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.47 ethambutol
embB 4248098 c.1585_1587delATCinsCG frameshift_variant&missense_variant 0.47 ethambutol
embB 4248106 c.1593C>T synonymous_variant 0.53 ethambutol Not assoc w R - Interim
embB 4248112 c.1599C>T synonymous_variant 0.6 ethambutol Not assoc w R - Interim
embB 4248115 c.1602C>T synonymous_variant 0.38 ethambutol Not assoc w R
embB 4248118 c.1605T>G synonymous_variant 0.63 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.66 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.67 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.67 ethambutol
embB 4248151 c.1638C>G synonymous_variant 0.7 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.68 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>A synonymous_variant 0.68 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.68 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.7 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.7 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.7 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.69 ethambutol
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.69 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.71 ethambutol Not assoc w R - Interim
embB 4248232 c.1719G>C synonymous_variant 0.74 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.76 ethambutol
embB 4248286 c.1773G>A synonymous_variant 0.73 ethambutol
embB 4248304 c.1791G>T synonymous_variant 0.74 ethambutol
embB 4248305 c.1792C>T synonymous_variant 0.74 ethambutol
embB 4248319 c.1806A>C synonymous_variant 0.62 ethambutol
embB 4248379 c.1866G>C synonymous_variant 0.42 ethambutol
embB 4248398 p.Leu629Val missense_variant 0.53 ethambutol
embB 4248406 c.1893G>C synonymous_variant 0.5 ethambutol
embB 4248407 c.1894_1896delTTAinsGG frameshift_variant&missense_variant 0.5 ethambutol
embB 4248412 c.1899C>T synonymous_variant 0.49 ethambutol Not assoc w R - Interim
embB 4248418 c.1905G>A synonymous_variant 0.5 ethambutol
embB 4248430 c.1917T>C synonymous_variant 0.5 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.5 ethambutol
embB 4248460 c.1947C>G synonymous_variant 0.48 ethambutol
embB 4248463 c.1950C>G synonymous_variant 0.45 ethambutol
embB 4248472 c.1959T>C synonymous_variant 0.46 ethambutol
embB 4248475 c.1962G>A synonymous_variant 0.49 ethambutol
embB 4248502 c.1989C>T synonymous_variant 0.51 ethambutol
embB 4248504 p.Asp664Ala missense_variant 0.51 ethambutol
embB 4248508 c.1995G>A synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embB 4248514 c.2001A>G synonymous_variant 0.49 ethambutol
embB 4249039 c.2526A>C synonymous_variant 0.39 ethambutol
embB 4249048 c.2535A>C synonymous_variant 0.55 ethambutol
embB 4249053 p.Thr847Ser missense_variant 0.54 ethambutol
embB 4249069 c.2556A>G synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embB 4249075 c.2562A>G synonymous_variant 0.54 ethambutol
embB 4249082 p.Thr857Arg missense_variant 0.52 ethambutol
embB 4249088 p.Val859Thr missense_variant 0.5 ethambutol
embB 4249102 c.2589T>C synonymous_variant 0.46 ethambutol
embB 4249104 p.Leu864Gln missense_variant 0.44 ethambutol
embB 4249111 c.2598T>C synonymous_variant 0.44 ethambutol
embB 4249115 c.2602_2604delCCGinsGC frameshift_variant&missense_variant 0.44 ethambutol
embB 4249138 c.2625C>G synonymous_variant 0.41 ethambutol
embB 4249147 c.2634C>T synonymous_variant 0.43 ethambutol
embB 4249163 p.Ala884Thr missense_variant 0.45 ethambutol
embB 4249366 c.2853G>A synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4249372 c.2859G>C synonymous_variant 0.38 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.39 ethambutol
embB 4249387 c.2874G>A synonymous_variant 0.4 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.58 ethambutol Uncertain significance
embB 4249432 c.2919A>G synonymous_variant 0.6 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.59 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.6 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.6 ethambutol
embB 4249454 p.Thr981Ser missense_variant 0.65 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.72 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.77 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.77 ethambutol
embB 4249519 c.3006C>T synonymous_variant 0.83 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.82 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.85 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.84 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.83 ethambutol
embB 4249540 c.3027C>A synonymous_variant 0.84 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.84 ethambutol
embB 4249568 c.3055_3057delTCGinsAC frameshift_variant&missense_variant 0.85 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.86 ethambutol
embB 4249576 c.3063G>A synonymous_variant 0.86 ethambutol
embB 4249581 p.Leu1023Gln missense_variant 0.87 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.88 ethambutol
embB 4249608 p.Thr1032Ile missense_variant 0.86 ethambutol
embB 4249618 c.3105C>T synonymous_variant 0.85 ethambutol
embB 4249627 c.3114G>C synonymous_variant 0.82 ethambutol
embB 4249637 p.Leu1042Val missense_variant 0.79 ethambutol
embB 4249648 c.3135G>C synonymous_variant 0.75 ethambutol
embB 4249678 c.3165C>G synonymous_variant 0.64 ethambutol
embB 4249693 c.3180T>C synonymous_variant 0.56 ethambutol
embB 4249699 c.3186T>A synonymous_variant 0.48 ethambutol
embB 4249702 c.3189C>A synonymous_variant 0.35 ethambutol
aftB 4267556 c.1281G>T synonymous_variant 0.38 ethambutol
aftB 4267577 c.1260C>T synonymous_variant 0.46 ethambutol Not assoc w R - Interim
aftB 4267580 c.1257G>A synonymous_variant 0.47 ethambutol
aftB 4267586 c.1251C>G synonymous_variant 0.48 ethambutol
aftB 4267592 c.1245C>G synonymous_variant 0.48 ethambutol Not assoc w R - Interim
aftB 4267601 c.1236C>G synonymous_variant 0.51 ethambutol
aftB 4267619 c.1218C>A synonymous_variant 0.53 ethambutol
aftB 4267622 c.1215G>C synonymous_variant 0.52 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.52 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.38 ethambutol Not assoc w R
aftB 4267649 c.1188T>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
aftB 4267655 c.1182C>A synonymous_variant 0.64 ethambutol Not assoc w R - Interim
aftB 4267667 c.1170A>G synonymous_variant 0.67 ethambutol
aftB 4267679 c.1158G>A synonymous_variant 0.64 ethambutol
aftB 4267685 c.1152T>C synonymous_variant 0.65 ethambutol
aftB 4267688 c.1149G>A synonymous_variant 0.62 ethambutol
aftB 4267695 p.Gly381Ala missense_variant 0.56 ethambutol
aftB 4267703 c.1134C>G synonymous_variant 0.52 ethambutol
aftB 4267707 p.Gly377Ala missense_variant 0.45 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.5 ethambutol
aftB 4269045 c.-209G>C upstream_gene_variant 0.5 ethambutol
ubiA 4269077 p.Ile253Val missense_variant 0.71 ethambutol
ubiA 4269088 p.Ala249Met missense_variant 0.69 ethambutol
aftB 4269099 c.-263G>C upstream_gene_variant 0.67 ethambutol
ubiA 4269102 p.Ser244Glu missense_variant 0.67 ethambutol
aftB 4269120 c.-284C>T upstream_gene_variant 0.69 ethambutol
aftB 4269129 c.-293G>C upstream_gene_variant 0.67 ethambutol
ubiA 4269132 c.702G>A synonymous_variant 0.62 ethambutol Not assoc w R - Interim
ubiA 4269143 p.Leu231Val missense_variant 0.56 ethambutol
ubiA 4269144 c.688_690delGTCinsTG frameshift_variant&synonymous_variant 0.56 ethambutol
ubiA 4269147 c.685_687delGTGinsCT frameshift_variant&missense_variant 0.56 ethambutol
aftB 4269150 c.-314G>A upstream_gene_variant 0.56 ethambutol
aftB 4269156 c.-320C>G upstream_gene_variant 0.58 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.61 ethambutol
aftB 4269177 c.-341G>C upstream_gene_variant 0.61 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R