0.92 rifampicin Uncertain significance rpoB 760973 c.1167G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim rpoB 760982 c.1176G>T synonymous_variant 1.0 rifampicin rpoB 760985 c.1179G>T synonymous_variant 1.0 rifampicin rpoB 760991 c.1185G>C synonymous_variant 1.0 rifampicin rpoB 761015 c.1209G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761027 c.1221A>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761036 c.1230G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761037 c.1231T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761051 c.1245G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761054 c.1248G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761057 c.1251G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761060 c.1254C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761063 c.1257C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761075 c.1269G>A synonymous_variant 0.98 rifampicin rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.98 rifampicin rpoB 761102 c.1296A>G synonymous_variant 0.98 rifampicin rpoB 761132 c.1326G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761133 c.1327T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761147 c.1341C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761150 c.1344A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761165 c.1359G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761175 c.1369C>T synonymous_variant 1.0 rifampicin rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761189 c.1383T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761198 c.1392G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim rpoB 761217 p.Pro471Ser missense_variant 0.96 rifampicin rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.96 rifampicin rpoB 761234 c.1428G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761249 c.1443A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761255 c.1449T>C synonymous_variant 0.96 rifampicin rpoB 761261 c.1455G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761264 c.1458C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoB 761273 c.1467T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim rpoB 761282 c.1476C>T synonymous_variant 0.93 rifampicin rpoB 761300 c.1494G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoB 761318 c.1512G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoB 761327 c.1521A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoB 761345 c.1539G>C synonymous_variant 0.91 rifampicin rpoB 761346 p.Val514Ile missense_variant 0.91 rifampicin rpoB 761354 c.1548C>T synonymous_variant 0.91 rifampicin rpoB 761360 c.1554T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoB 761362 p.Ser519Thr missense_variant 0.96 rifampicin rpoB 761367 p.Glu521Gln missense_variant 0.91 rifampicin rpoB 761374 p.Val523Asp missense_variant 0.96 rifampicin rpoB 761408 c.1602G>C synonymous_variant 0.93 rifampicin rpoB 761414 c.1608A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoB 761537 c.1731C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761555 c.1749G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoB 761558 c.1752C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoB 761561 c.1755C>G synonymous_variant 0.94 rifampicin rpoB 761570 c.1764T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761579 c.1773G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761606 c.1800C>G synonymous_variant 1.0 rifampicin rpoB 761612 c.1806G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761615 c.1809A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761636 c.1830G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 761645 c.1839C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761648 c.1842T>C synonymous_variant 1.0 rifampicin rpoB 761666 c.1860G>C synonymous_variant 1.0 rifampicin rpoB 761675 c.1869G>T synonymous_variant 0.97 rifampicin rpoB 761681 c.1875G>A synonymous_variant 1.0 rifampicin rpoB 761690 c.1884G>C synonymous_variant 0.97 rifampicin rpoB 761711 c.1905C>G synonymous_variant 0.92 rifampicin rpoB 761717 c.1911C>G synonymous_variant 0.9 rifampicin rpoB 761718 p.Ala638Thr missense_variant 0.89 rifampicin rpoB 761722 c.1918_1919delGA frameshift_variant 1.0 rifampicin rpoB 761728 c.1922_1923insGC frameshift_variant 0.94 rifampicin rpoB 761732 c.1926C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761735 c.1929C>G synonymous_variant 1.0 rifampicin rpoB 761736 p.Ile644Val missense_variant 0.89 rifampicin Uncertain significance rpoB 761747 c.1941G>C synonymous_variant 0.94 rifampicin rpoB 761750 c.1944G>C synonymous_variant 1.0 rifampicin rpoB 761765 c.1959T>C synonymous_variant 1.0 rifampicin rpoB 761772 p.His656Ala missense_variant 1.0 rifampicin rpoB 761778 p.Asn658Asp missense_variant 1.0 rifampicin rpoB 761791 p.Arg662His missense_variant 1.0 rifampicin rpoB 761813 c.2007T>C synonymous_variant 1.0 rifampicin rpoB 761816 c.2010C>G synonymous_variant 0.96 rifampicin rpoB 761819 c.2013G>C synonymous_variant 0.96 rifampicin rpoB 761834 c.2028T>G synonymous_variant 1.0 rifampicin rpoB 761847 p.Cys681Arg missense_variant 1.0 rifampicin Uncertain significance rpoB 761852 c.2046C>G synonymous_variant 1.0 rifampicin rpoB 761864 c.2058G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761867 c.2061C>G synonymous_variant 1.0 rifampicin rpoB 761868 p.Asp688Gln missense_variant 0.95 rifampicin rpoB 761873 c.2067A>G synonymous_variant 1.0 rifampicin rpoB 761880 p.Ala692Ser missense_variant 0.95 rifampicin rpoB 761885 c.2079T>C synonymous_variant 1.0 rifampicin rpoB 761892 p.Ile696Leu missense_variant 0.95 rifampicin rpoB 761903 c.2097T>G synonymous_variant 0.95 rifampicin rpoB 761906 c.2100C>G synonymous_variant 1.0 rifampicin rpoB 761909 c.2103T>C synonymous_variant 1.0 rifampicin rpoB 761912 c.2106T>C synonymous_variant 1.0 rifampicin rpoB 761915 p.Asp703Glu missense_variant 1.0 rifampicin rpoB 761916 p.Asp704Asn missense_variant 1.0 rifampicin rpoB 761921 c.2115C>T synonymous_variant 0.96 rifampicin rpoB 761948 c.2142G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761954 c.2148C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 761999 c.2193G>C synonymous_variant 1.0 rifampicin rpoB 762014 c.2208C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762017 c.2211A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762038 c.2232C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 762053 c.2247T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762065 c.2259T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762078 c.2272C>T synonymous_variant 0.98 rifampicin rpoB 762083 c.2277T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762086 c.2280G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762101 c.2295C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762114 p.Ile770Val missense_variant 1.0 rifampicin Uncertain significance rpoB 762122 c.2316C>T synonymous_variant 0.93 rifampicin rpoB 762131 c.2325C>G synonymous_variant 1.0 rifampicin rpoB 762137 c.2331C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoB 762140 c.2334G>C synonymous_variant 0.98 rifampicin rpoB 762143 c.2337T>C synonymous_variant 1.0 rifampicin rpoB 762149 c.2343G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762156 p.Val784Ile missense_variant 0.95 rifampicin rpoB 762167 c.2361T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762176 c.2370T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoB 762185 c.2379G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762218 c.2412T>C synonymous_variant 0.98 rifampicin rpoB 762233 c.2427G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoB 762236 c.2430G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoB 762245 c.2439G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoB 762254 c.2448T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762284 c.2478G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762287 c.2481C>G synonymous_variant 0.97 rifampicin rpoB 762293 c.2487T>G synonymous_variant 1.0 rifampicin rpoB 762308 c.2502G>T synonymous_variant 0.98 rifampicin rpoB 762314 c.2508C>T synonymous_variant 0.98 rifampicin rpoB 762317 c.2511A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762329 c.2523G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762338 c.2532T>C synonymous_variant 1.0 rifampicin rpoB 762341 c.2535G>C synonymous_variant 0.98 rifampicin rpoB 762347 c.2541T>C synonymous_variant 1.0 rifampicin rpoB 762350 c.2544C>G synonymous_variant 0.96 rifampicin rpoB 762362 p.Glu852Asp missense_variant 1.0 rifampicin rpoB 762369 c.2563T>C synonymous_variant 1.0 rifampicin rpoC 762374 c.-996G>C upstream_gene_variant 1.0 rifampicin rpoC 762395 c.-975G>C upstream_gene_variant 1.0 rifampicin rpoC 762398 c.-972T>C upstream_gene_variant 1.0 rifampicin rpoC 762401 c.-969G>C upstream_gene_variant 1.0 rifampicin rpoB 762404 c.2598T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 762410 c.-960T>C upstream_gene_variant 1.0 rifampicin rpoB 762416 c.2610A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 762434 c.-936T>C upstream_gene_variant 1.0 rifampicin rpoC 762443 c.-927G>C upstream_gene_variant 1.0 rifampicin rpoB 762449 c.2643C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762452 c.2646G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762470 c.2664G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762491 c.2685T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 762509 c.-861T>G upstream_gene_variant 1.0 rifampicin rpoB 762510 p.Ala902Pro missense_variant 1.0 rifampicin Uncertain significance rpoC 762533 c.-837T>C upstream_gene_variant 1.0 rifampicin rpoC 762536 c.-834T>C upstream_gene_variant 1.0 rifampicin rpoC 762537 c.-833T>C upstream_gene_variant 1.0 rifampicin rpoC 762551 c.-819C>T upstream_gene_variant 1.0 rifampicin rpoC 762560 c.-810A>T upstream_gene_variant 1.0 rifampicin rpoC 762563 c.-807G>T upstream_gene_variant 1.0 rifampicin rpoC 762581 c.-789T>C upstream_gene_variant 1.0 rifampicin rpoC 762582 c.-788T>C upstream_gene_variant 1.0 rifampicin rpoB 762827 c.3021G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 762833 c.3027C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim rpoC 762839 c.-531G>A upstream_gene_variant 0.85 rifampicin rpoB 762857 c.3051C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 762863 c.-507T>G upstream_gene_variant 1.0 rifampicin rpoB 762879 p.Met1025Leu missense_variant 0.88 rifampicin Uncertain significance rpoC 762917 c.-453C>T upstream_gene_variant 0.95 rifampicin rpoB 762929 c.3123G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 762983 c.-387C>T upstream_gene_variant 0.95 rifampicin rpoB 762995 c.3189G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 763028 c.3222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 763034 c.3228C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 763040 c.3234C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763052 c.-318G>C upstream_gene_variant 0.96 rifampicin rpoB 763053 c.3247T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 763058 c.-312C>G upstream_gene_variant 0.94 rifampicin rpoB 763070 c.3264T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 763094 c.3288G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 763127 c.3321G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim rpoC 763142 c.-228C>G upstream_gene_variant 0.9 rifampicin rpoC 763160 c.-210G>T upstream_gene_variant 0.9 rifampicin rpoB 763166 c.3360A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763200 c.-170_-168delCTAinsTTG upstream_gene_variant 0.88 rifampicin rpoC 763205 c.-165G>T upstream_gene_variant 1.0 rifampicin rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 1.0 rifampicin rpoB 763214 c.3408T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763226 c.-144A>G upstream_gene_variant 1.0 rifampicin rpoB 763227 p.Leu1141Met missense_variant 0.77 rifampicin rpoC 763232 c.-138C>T upstream_gene_variant 0.85 rifampicin rpoB 763235 p.Glu1143Asp missense_variant 0.85 rifampicin rpoB 763238 c.3432T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoB 763241 p.Glu1145Asp missense_variant 0.92 rifampicin rpoC 763259 c.-111G>C upstream_gene_variant 0.91 rifampicin rpoC 763262 c.-108C>T upstream_gene_variant 0.9 rifampicin rpoB 763265 c.3459G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim rpoC 763274 c.-96G>C upstream_gene_variant 0.82 rifampicin rpoC 763375 c.6C>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim rpoC 763411 c.42T>C synonymous_variant 1.0 rifampicin rpoC 763414 c.45T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763423 p.Glu18Asp missense_variant 0.96 rifampicin Uncertain significance rpoC 763430 c.61_63delAGGinsCGC synonymous_variant 0.96 rifampicin rpoC 763433 p.Gln22Asn missense_variant 0.96 rifampicin rpoC 763443 p.Tyr25Phe missense_variant 0.96 rifampicin rpoC 763468 c.99G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763486 c.117T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763492 c.123G>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 763528 c.159G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763531 c.162G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 763546 c.177A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763570 c.201G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763573 c.204G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 763576 c.207C>G synonymous_variant 0.92 rifampicin rpoC 763594 c.225C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763621 c.252C>T synonymous_variant 0.93 rifampicin rpoC 763660 c.291T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763666 c.297G>T synonymous_variant 0.95 rifampicin rpoC 763675 c.306C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763696 c.327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763702 c.333C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763709 c.340C>T synonymous_variant 1.0 rifampicin rpoC 763714 c.345G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763717 c.348T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763723 c.354G>C synonymous_variant 1.0 rifampicin rpoC 763732 c.363C>T synonymous_variant 0.98 rifampicin rpoC 763741 c.372C>T synonymous_variant 0.93 rifampicin rpoC 763744 c.375G>C synonymous_variant 1.0 rifampicin rpoC 763765 c.396T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763771 c.402C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 763781 p.Ser138Ala missense_variant 0.93 rifampicin rpoC 763787 p.Asp140Asn missense_variant 0.92 rifampicin rpoC 763792 p.Glu141Asp missense_variant 0.94 rifampicin rpoC 763807 c.438T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 763813 c.444C>G synonymous_variant 0.93 rifampicin rpoC 763822 c.453C>G synonymous_variant 0.83 rifampicin rpoC 763825 c.456G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim rpoC 763831 c.462A>G synonymous_variant 0.96 rifampicin rpoC 763837 c.468G>C synonymous_variant 0.87 rifampicin rpoC 763840 c.471G>C synonymous_variant 0.87 rifampicin rpoC 763858 c.489A>G synonymous_variant 1.0 rifampicin rpoC 763872 p.Gly168Ala missense_variant 1.0 rifampicin rpoC 763876 p.Glu169Asp missense_variant 0.93 rifampicin rpoC 763879 c.510A>G synonymous_variant 1.0 rifampicin rpoC 764161 c.792G>C synonymous_variant 0.9 rifampicin rpoC 764353 c.984G>C synonymous_variant 0.88 rifampicin rpoC 764365 c.996C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 764371 c.1002G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim rpoC 764377 c.1008C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim rpoC 764380 c.1011G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764383 c.1014C>G synonymous_variant 0.82 rifampicin rpoC 764386 c.1017C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764395 c.1026C>T synonymous_variant 0.89 rifampicin rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764431 c.1062G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoC 764434 c.1065A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.91 rifampicin rpoC 764446 c.1077T>C synonymous_variant 1.0 rifampicin rpoC 764449 c.1080G>C synonymous_variant 1.0 rifampicin rpoC 764452 c.1083T>C synonymous_variant 0.96 rifampicin rpoC 764458 c.1089G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764461 c.1092A>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoC 764485 c.1116G>C synonymous_variant 0.97 rifampicin rpoC 764491 c.1122G>T synonymous_variant 0.97 rifampicin rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764500 c.1131C>G synonymous_variant 0.97 rifampicin rpoC 764521 c.1152T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764527 c.1158C>G synonymous_variant 0.96 rifampicin rpoC 764551 c.1182G>C synonymous_variant 0.97 rifampicin rpoC 764575 c.1206T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764605 c.1236G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim rpoC 764611 c.1242G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim rpoC 764626 c.1257C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoC 764632 c.1263T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764650 c.1281G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoC 764713 c.1344G>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoC 764716 c.1347G>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim rpoC 764746 c.1377G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764758 c.1389C>G synonymous_variant 0.99 rifampicin Not assoc w R - Interim rpoC 764764 c.1395T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764797 c.1428G>C synonymous_variant 0.96 rifampicin rpoC 764803 c.1434C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 764809 c.1440C>T synonymous_variant 1.0 rifampicin Not assoc w R rpoC 764815 c.1446A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764827 c.1458G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 764843 p.Ala492Ser missense_variant 0.95 rifampicin rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764875 c.1506C>A synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 764887 c.1518G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.94 rifampicin rpoC 764911 c.1542A>G synonymous_variant 1.0 rifampicin rpoC 764912 p.Met515Gln missense_variant 0.94 rifampicin Uncertain significance rpoC 764923 c.1554A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764935 c.1566T>C synonymous_variant 0.94 rifampicin rpoC 764948 c.1579T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim rpoC 764953 c.1584G>C synonymous_variant 0.97 rifampicin rpoC 764968 c.1599T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 764983 c.1614T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim rpoC 765349 c.1980T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim rpoC 765352 c.1983G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim rpoC 765357 p.Met663Thr missense_variant 0.8 rifampicin rpoC 765361 c.1992C>G synonymous_variant 0.83 rifampicin rpoC 765370 c.2001G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim rpoC 765379 c.2010G>T synonymous_variant 0.94 rifampicin rpoC 765383 p.Met672Leu missense_variant 1.0 rifampicin Uncertain significance rpoC 765405 p.Leu679Arg missense_variant 0.96 rifampicin Uncertain significance rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin rpoC 765412 c.2043T>C synonymous_variant 1.0 rifampicin rpoC 765445 c.2076G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 765451 c.2082C>G synonymous_variant 1.0 rifampicin rpoC 765454 c.2085C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765466 c.2097C>T synonymous_variant 0.95 rifampicin rpoC 765469 c.2100G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765499 c.2130C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765508 c.2139C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765529 c.2160C>G synonymous_variant 0.9 rifampicin rpoC 765533 p.Tyr722His missense_variant 0.9 rifampicin Uncertain significance rpoC 765811 c.2442T>G synonymous_variant 1.0 rifampicin rpoC 765814 c.2445A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765817 c.2448G>A synonymous_variant 0.89 rifampicin rpoC 765826 c.2457T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765835 c.2466C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765850 c.2481G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoC 765856 c.2487T>C synonymous_variant 0.92 rifampicin rpoC 765875 p.Val836Ile missense_variant 0.94 rifampicin Uncertain significance rpoC 765886 c.2517C>G synonymous_variant 1.0 rifampicin rpoC 765892 c.2523T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765898 c.2529C>T synonymous_variant 0.95 rifampicin rpoC 765904 c.2535C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim rpoC 765937 c.2568T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 765947 c.2578T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 765961 c.2592G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim rpoC 765962 c.2593_2595delTTGinsCTT synonymous_variant 0.92 rifampicin rpoC 765967 c.2598C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765979 c.2610C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoC 765982 c.2613C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 765994 c.2625A>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766003 c.2634G>C synonymous_variant 0.86 rifampicin rpoC 766012 c.2643C>A synonymous_variant 0.89 rifampicin rpoC 766021 c.2652G>C synonymous_variant 1.0 rifampicin rpoC 766321 c.2952C>G synonymous_variant 0.8 rifampicin rpoC 766345 c.2976T>C synonymous_variant 1.0 rifampicin rpoC 766348 c.2979A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766369 c.3000C>G synonymous_variant 0.88 rifampicin rpoC 766381 c.3012C>T synonymous_variant 1.0 rifampicin rpoC 766384 c.3015A>G synonymous_variant 1.0 rifampicin rpoC 766393 c.3024C>G synonymous_variant 0.89 rifampicin rpoC 766408 c.3039C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766425 c.3056_3057insTGTCAC disruptive_inframe_insertion 1.0 rifampicin rpoC 766428 p.Val1020Gly missense_variant 0.92 rifampicin rpoC 766434 p.Glu1022Ala missense_variant 0.92 rifampicin rpoC 766442 p.Thr1025Val missense_variant 0.92 rifampicin rpoC 766459 c.3090G>C synonymous_variant 0.93 rifampicin rpoC 766672 c.3303T>C synonymous_variant 1.0 rifampicin rpoC 766690 c.3321G>C synonymous_variant 0.8 rifampicin rpoC 766703 p.Met1112Leu missense_variant 0.82 rifampicin rpoC 766711 c.3342C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim rpoC 766726 c.3357T>C synonymous_variant 1.0 rifampicin rpoC 766738 c.3369G>C synonymous_variant 1.0 rifampicin rpoC 766741 c.3372G>C synonymous_variant 0.86 rifampicin rpoC 766747 c.3378C>T synonymous_variant 0.87 rifampicin rpoC 766765 c.3396A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766771 c.3402G>C synonymous_variant 0.88 rifampicin rpoC 766774 c.3405T>C synonymous_variant 1.0 rifampicin rpoC 766775 p.Arg1136Lys missense_variant 0.88 rifampicin rpoC 766804 c.3435A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766837 c.3468G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoC 766843 c.3474T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 766846 c.3477C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim rpoC 766858 c.3489C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoC 766861 c.3492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766864 c.3495G>C synonymous_variant 1.0 rifampicin rpoC 766867 c.3498C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoC 766876 c.3507C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoC 766882 c.3513C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766883 p.Ser1172Ala missense_variant 1.0 rifampicin Uncertain significance rpoC 766931 p.Ala1188Thr missense_variant 1.0 rifampicin Uncertain significance rpoC 766942 c.3573C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766945 c.3576A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766948 c.3579G>C synonymous_variant 1.0 rifampicin rpoC 766963 c.3594T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 766978 c.3609C>A synonymous_variant 1.0 rifampicin rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767008 c.3639G>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoC 767020 c.3651C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoC 767023 c.3654C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoC 767059 c.3690T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767098 c.3729T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767104 c.3735C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoC 767105 p.Asn1246Gln missense_variant 0.93 rifampicin Uncertain significance rpoC 767119 c.3750A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767149 c.3780C>A synonymous_variant 0.93 rifampicin rpoC 767152 c.3783T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim rpoC 767158 c.3789T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767167 c.3798C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767180 p.Ala1271Gln missense_variant 0.98 rifampicin rpoC 767191 c.3822C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoC 767200 c.3831G>A synonymous_variant 0.95 rifampicin rpoC 767221 c.3852C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767230 c.3861G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoC 767233 c.3864T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767263 c.3894T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767264 p.Ala1299Gln missense_variant 1.0 rifampicin rpoC 767269 c.3900C>G synonymous_variant 1.0 rifampicin rpoC 767281 c.3912C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoC 767284 c.3915C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim mmpL5 775825 p.Leu886Met missense_variant 1.0 bedaquiline clofazimine mmpL5 775826 c.2655G>C synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775832 c.2649C>G synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775842 p.Val880Thr missense_variant 1.0 bedaquiline clofazimine mmpL5 775847 c.2634G>T synonymous_variant 0.94 bedaquiline Not assoc w R - Interim clofazimine Not assoc w R - Interim mmpL5 775856 c.2625T>C synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775864 p.Ala873Thr missense_variant 1.0 bedaquiline clofazimine mmpL5 775865 c.2616T>G synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775871 p.Ile870Met missense_variant 1.0 bedaquiline clofazimine mmpL5 775880 p.Asn867Lys missense_variant 1.0 bedaquiline clofazimine mmpL5 775883 p.Ile866Leu missense_variant 1.0 bedaquiline clofazimine mmpL5 775907 c.2574C>G synonymous_variant 0.81 bedaquiline clofazimine mmpL5 775910 c.2571G>C synonymous_variant 0.79 bedaquiline clofazimine mmpL5 775916 c.2565T>C synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775919 p.Leu854Val missense_variant 0.72 bedaquiline clofazimine mmpL5 775924 c.2557C>T synonymous_variant 0.6 bedaquiline clofazimine Not assoc w R - Interim mmpL5 775940 c.2541C>G synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775943 c.2538C>G synonymous_variant 0.94 bedaquiline clofazimine mmpL5 775946 c.2535C>G synonymous_variant 0.98 bedaquiline clofazimine mmpL5 775961 c.2520C>G synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775972 p.Ala837Pro missense_variant 0.97 bedaquiline clofazimine mmpL5 775975 c.2506T>C synonymous_variant 1.0 bedaquiline clofazimine mmpL5 775981 p.Leu834Met missense_variant 1.0 bedaquiline clofazimine mmpL5 775990 c.2491C>T synonymous_variant 0.37 bedaquiline clofazimine mmpL5 775991 c.2490G>A synonymous_variant 0.61 bedaquiline clofazimine mmpL5 775997 c.2484T>C synonymous_variant 1.0 bedaquiline clofazimine mmpL5 776000 p.Leu827Ile missense_variant 0.68 bedaquiline clofazimine mmpL5 776009 c.2472A>G synonymous_variant 1.0 bedaquiline clofazimine mmpL5 776015 p.Ile822Val missense_variant 0.97 bedaquiline clofazimine mmpL5 776039 c.2442C>G synonymous_variant 1.0 bedaquiline clofazimine mmpL5 776042 c.2439C>T synonymous_variant 0.95 bedaquiline clofazimine mmpL5 776048 c.2433G>C synonymous_variant 0.94 bedaquiline clofazimine mmpL5 776053 c.2428T>C synonymous_variant 1.0 bedaquiline clofazimine mmpL5 776060 c.2421C>G synonymous_variant 0.82 bedaquiline clofazimine rpsL 781572 p.Gln5Asn missense_variant 1.0 streptomycin rpsL 781586 c.27C>T synonymous_variant 0.9 streptomycin rpsL 781595 c.36T>C synonymous_variant 0.9 streptomycin rpsL 781598 c.39G>C synonymous_variant 0.9 streptomycin rpsL 781608 p.Ser17Ala missense_variant 1.0 streptomycin rpsL 781628 c.69T>A synonymous_variant 1.0 streptomycin rpsL 781631 c.72G>C synonymous_variant 0.91 streptomycin rpsL 781634 c.75G>A synonymous_variant 0.91 streptomycin rpsL 781652 c.93T>C synonymous_variant 0.92 streptomycin rpsL 781655 c.96T>C synonymous_variant 1.0 streptomycin rpsL 781658 c.99A>G synonymous_variant 0.93 streptomycin rpsL 781679 c.120C>G synonymous_variant 0.95 streptomycin rpsL 781682 c.123T>C synonymous_variant 1.0 streptomycin rpsL 781709 c.150G>C synonymous_variant 0.91 streptomycin Not assoc w R - Interim rpsL 781715 c.156T>C synonymous_variant 1.0 streptomycin rpsL 781718 c.159C>G synonymous_variant 1.0 streptomycin rpsL 781725 p.Lys56Arg missense_variant 0.88 streptomycin rpsL 781728 c.169T>C synonymous_variant 1.0 streptomycin rpsL 781733 c.174G>C synonymous_variant 0.95 streptomycin rpsL 781736 c.177T>C synonymous_variant 1.0 streptomycin rpsL 781737 p.Gln60Ala missense_variant 0.95 streptomycin rpsL 781751 c.192G>C synonymous_variant 0.97 streptomycin rpsL 781754 c.195G>A synonymous_variant 1.0 streptomycin Not assoc w R - Interim rpsL 781760 c.201T>C synonymous_variant 0.97 streptomycin rpsL 781769 c.210G>A synonymous_variant 0.97 streptomycin rpsL 781802 c.243G>C synonymous_variant 0.98 streptomycin rpsL 781814 c.255C>T synonymous_variant 0.98 streptomycin rpsL 781817 c.258G>T synonymous_variant 0.98 streptomycin rpsL 781829 c.270G>C synonymous_variant 0.98 streptomycin rpsL 781832 c.273T>C synonymous_variant 1.0 streptomycin rpsL 781835 c.276T>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim rpsL 781859 c.300T>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin rpsL 781877 c.318T>C synonymous_variant 1.0 streptomycin rpsL 781892 c.333A>G synonymous_variant 1.0 streptomycin rpsL 781895 c.336G>A synonymous_variant 1.0 streptomycin rpsL 781898 c.339A>C synonymous_variant 1.0 streptomycin rpsL 781916 c.357T>G synonymous_variant 1.0 streptomycin rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance rplC 800543 c.-266C>T upstream_gene_variant 1.0 linezolid rplC 800546 c.-263T>C upstream_gene_variant 1.0 linezolid rplC 800549 c.-260G>T upstream_gene_variant 1.0 linezolid rplC 800567 c.-242A>G upstream_gene_variant 1.0 linezolid rplC 800570 c.-239C>G upstream_gene_variant 1.0 linezolid rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 1.0 linezolid rplC 800579 c.-230C>G upstream_gene_variant 1.0 linezolid rplC 800582 c.-227C>G upstream_gene_variant 1.0 linezolid rplC 800585 c.-224T>A upstream_gene_variant 1.0 linezolid rplC 800591 c.-218C>T upstream_gene_variant 1.0 linezolid rplC 800594 c.-215C>G upstream_gene_variant 1.0 linezolid rplC 800597 c.-212A>C upstream_gene_variant 1.0 linezolid rplC 800600 c.-209G>C upstream_gene_variant 1.0 linezolid rplC 800612 c.-197A>G upstream_gene_variant 1.0 linezolid rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid rplC 800633 c.-176T>C upstream_gene_variant 1.0 linezolid rplC 800645 c.-164C>G upstream_gene_variant 1.0 linezolid rplC 800648 c.-161A>C upstream_gene_variant 1.0 linezolid rplC 800654 c.-155T>C upstream_gene_variant 1.0 linezolid rplC 800690 c.-119C>T upstream_gene_variant 1.0 linezolid rplC 800693 c.-116A>G upstream_gene_variant 1.0 linezolid rplC 800703 c.-106T>C upstream_gene_variant 1.0 linezolid rplC 800715 c.-94A>C upstream_gene_variant 1.0 linezolid rplC 800720 c.-89T>C upstream_gene_variant 1.0 linezolid rplC 800735 c.-74C>G upstream_gene_variant 1.0 linezolid rplC 800738 c.-71T>C upstream_gene_variant 1.0 linezolid rplC 800747 c.-62C>G upstream_gene_variant 1.0 linezolid rplC 800753 c.-56C>T upstream_gene_variant 1.0 linezolid rplC 800762 c.-47T>G upstream_gene_variant 1.0 linezolid rplC 800796 c.-12_-9delTTGG upstream_gene_variant 1.0 linezolid rplC 800806 c.-3G>A upstream_gene_variant 1.0 linezolid rplC 800808 c.-1A>C upstream_gene_variant 1.0 linezolid Uncertain significance rplC 800815 c.7C>A synonymous_variant 1.0 linezolid rplC 800820 c.12G>A synonymous_variant 1.0 linezolid rplC 800829 c.21C>G synonymous_variant 1.0 linezolid rplC 800844 c.36T>C synonymous_variant 1.0 linezolid rplC 800856 c.48A>G synonymous_variant 1.0 linezolid rplC 800865 c.57A>G synonymous_variant 1.0 linezolid rplC 800867 p.Ser20Asn missense_variant 1.0 linezolid rplC 800873 p.Arg22Lys missense_variant 1.0 linezolid rplC 800877 c.69A>C synonymous_variant 1.0 linezolid rplC 800880 c.72A>G synonymous_variant 1.0 linezolid rplC 800889 c.81C>G synonymous_variant 1.0 linezolid rplC 800892 c.84G>C synonymous_variant 1.0 linezolid rplC 800910 c.102C>T synonymous_variant 1.0 linezolid fbiC 1303545 c.615A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303581 c.651G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303584 c.654C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303587 c.657G>A synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303590 c.660A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303594 c.664C>T synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303602 c.672A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303611 c.681G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303614 c.684C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303632 c.702T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303827 p.Glu299Asp missense_variant 0.82 pretomanid delamanid clofazimine fbiC 1303835 p.Ala302Val missense_variant 0.82 pretomanid delamanid clofazimine fbiC 1303844 p.Ala305Asp missense_variant 0.75 pretomanid delamanid clofazimine fbiC 1303846 p.Phe306Val missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1303861 p.Ile311Leu missense_variant 0.73 pretomanid delamanid clofazimine fbiC 1303866 p.Glu312Asp missense_variant 0.73 pretomanid delamanid clofazimine fbiC 1303871 p.Tyr314Phe missense_variant 0.67 pretomanid delamanid clofazimine fbiC 1303881 c.951G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1303882 p.Val318Ile missense_variant 0.67 pretomanid delamanid clofazimine fbiC 1303891 p.Ala321Thr missense_variant 0.69 pretomanid delamanid clofazimine fbiC 1303903 p.Leu325Met missense_variant 0.75 pretomanid delamanid clofazimine fbiC 1303912 p.GlyMet328LysVal missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1303948 p.Gly340Arg missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1304001 c.1071C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304008 c.1078T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304022 c.1092T>C synonymous_variant 0.87 pretomanid delamanid clofazimine fbiC 1304031 c.1101C>G synonymous_variant 0.88 pretomanid delamanid clofazimine fbiC 1304034 c.1104A>G synonymous_variant 0.94 pretomanid delamanid clofazimine fbiC 1304049 c.1119T>G synonymous_variant 0.9 pretomanid delamanid clofazimine fbiC 1304059 c.1129C>T synonymous_variant 0.9 pretomanid delamanid clofazimine fbiC 1304064 c.1134G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304092 p.Met388Leu missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1304115 c.1185A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304481 c.1551T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304487 c.1557C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304496 c.1566T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304499 c.1569T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304503 c.1573C>T synonymous_variant 1.0 pretomanid delamanid Not assoc w R - Interim clofazimine Not assoc w R - Interim fbiC 1304514 c.1584T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304515 p.Ala529Thr missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1304526 c.1596T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304533 c.1603T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304544 c.1614T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304559 p.Glu543Asp missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1304562 c.1632G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304565 c.1635C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304568 c.1638T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304574 c.1644C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304580 c.1650T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304613 c.1683T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304634 c.1704C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304637 c.1707G>A synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304640 c.1710A>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304646 c.1716T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304652 c.1722C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304665 c.1735C>T synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304670 c.1740G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304671 p.Val581Thr missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1304675 p.Gly582Asp missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1304688 p.Asp586Glu missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1304691 c.1761G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304694 c.1764A>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304703 c.1773C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304709 c.1779C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304715 c.1785G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304724 c.1794A>G synonymous_variant 1.0 pretomanid delamanid Not assoc w R - Interim clofazimine Not assoc w R - Interim fbiC 1304727 c.1797A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304742 c.1812T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304748 c.1818T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304751 c.1821C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304754 c.1824G>A synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304757 c.1827A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304763 c.1833C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304772 c.1842C>T synonymous_variant 1.0 pretomanid delamanid Not assoc w R - Interim clofazimine Not assoc w R - Interim fbiC 1304784 c.1854T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304787 c.1857T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304790 c.1860C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304808 c.1878C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304811 c.1881C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304817 c.1887T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304829 c.1899T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304832 c.1902C>G synonymous_variant 1.0 pretomanid delamanid Not assoc w R - Interim clofazimine Not assoc w R - Interim fbiC 1304871 c.1941G>C synonymous_variant 0.83 pretomanid delamanid clofazimine fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304877 c.1947T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304880 c.1950C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304883 c.1953G>A synonymous_variant 0.82 pretomanid delamanid clofazimine fbiC 1304907 c.1977C>G synonymous_variant 0.85 pretomanid delamanid clofazimine fbiC 1304910 c.1980G>C synonymous_variant 0.85 pretomanid delamanid clofazimine fbiC 1304916 c.1986T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304919 c.1989C>G synonymous_variant 0.85 pretomanid delamanid clofazimine fbiC 1304925 c.1995G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304937 c.2007G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304940 c.2010A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304946 c.2016G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304952 c.2022C>T synonymous_variant 0.93 pretomanid delamanid clofazimine fbiC 1304958 c.2028T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304994 c.2064A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1304995 p.Leu689Met missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1305006 c.2076A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305007 p.Ile693Val missense_variant 1.0 pretomanid delamanid Uncertain significance clofazimine Uncertain significance fbiC 1305012 c.2082G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305015 c.2085G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305021 c.2091C>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305030 c.2100G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305033 c.2103T>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305042 c.2112A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305043 c.2113_2115delTCAinsAGC synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305063 c.2133G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305066 c.2136T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305069 c.2139G>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305074 p.Ser715Thr missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1305078 c.2148A>G synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305092 p.Ala721Gly missense_variant 1.0 pretomanid delamanid clofazimine fbiC 1305099 c.2169T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305330 c.2400C>G synonymous_variant 0.69 pretomanid delamanid clofazimine fbiC 1305336 c.2406T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305351 c.2421G>C synonymous_variant 0.69 pretomanid delamanid clofazimine fbiC 1305393 c.2463T>C synonymous_variant 0.77 pretomanid delamanid clofazimine fbiC 1305396 c.2466C>G synonymous_variant 0.77 pretomanid delamanid clofazimine fbiC 1305399 c.2469A>G synonymous_variant 0.77 pretomanid delamanid clofazimine fbiC 1305400 p.His824Asn missense_variant 0.77 pretomanid delamanid clofazimine fbiC 1305405 c.2475A>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305423 c.2493T>C synonymous_variant 1.0 pretomanid delamanid clofazimine fbiC 1305429 c.2499G>C synonymous_variant 0.77 pretomanid delamanid clofazimine sigE 1364659 c.247_248delTCinsAG synonymous_variant 1.0 pyrazinamide sigE 1364676 c.264C>G synonymous_variant 1.0 pyrazinamide sigE 1364685 c.273C>T synonymous_variant 1.0 pyrazinamide sigE 1364703 c.291G>C synonymous_variant 1.0 pyrazinamide sigE 1364709 c.297T>C synonymous_variant 1.0 pyrazinamide sigE 1364712 c.300T>C synonymous_variant 1.0 pyrazinamide sigE 1364715 c.303G>C synonymous_variant 1.0 pyrazinamide sigE 1364716 c.304_306delCTCinsTTG synonymous_variant 1.0 pyrazinamide sigE 1364721 c.309C>G synonymous_variant 1.0 pyrazinamide sigE 1364742 c.330A>G synonymous_variant 1.0 pyrazinamide sigE 1364751 c.339C>G synonymous_variant 0.95 pyrazinamide sigE 1364760 c.348C>G synonymous_variant 0.94 pyrazinamide sigE 1364763 c.351T>C synonymous_variant 1.0 pyrazinamide sigE 1364767 c.355_357delAGGinsCGC synonymous_variant 1.0 pyrazinamide sigE 1364784 c.372C>G synonymous_variant 1.0 pyrazinamide sigE 1364790 c.378T>C synonymous_variant 0.91 pyrazinamide sigE 1364799 c.387G>C synonymous_variant 0.9 pyrazinamide sigE 1364805 c.393C>G synonymous_variant 0.91 pyrazinamide sigE 1364811 c.399A>G synonymous_variant 1.0 pyrazinamide sigE 1364818 c.406_408delCTAinsTTG synonymous_variant 0.91 pyrazinamide sigE 1364835 c.423C>G synonymous_variant 1.0 pyrazinamide sigE 1364839 c.427T>C synonymous_variant 1.0 pyrazinamide sigE 1364847 c.435G>C synonymous_variant 0.93 pyrazinamide sigE 1364856 c.444C>G synonymous_variant 0.93 pyrazinamide sigE 1364859 c.447C>T synonymous_variant 0.93 pyrazinamide sigE 1364865 c.453G>T synonymous_variant 1.0 pyrazinamide sigE 1364867 p.Ala152Gly missense_variant 0.93 pyrazinamide sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 1.0 pyrazinamide sigE 1364898 c.486C>T synonymous_variant 0.95 pyrazinamide sigE 1364919 c.507T>C synonymous_variant 1.0 pyrazinamide sigE 1364925 c.513C>G synonymous_variant 0.97 pyrazinamide sigE 1364950 p.Ala180Ser missense_variant 1.0 pyrazinamide sigE 1364958 c.546G>C synonymous_variant 1.0 pyrazinamide sigE 1364961 c.549A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim sigE 1364964 c.552T>G synonymous_variant 1.0 pyrazinamide sigE 1364976 c.564T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim sigE 1364980 c.568T>C synonymous_variant 1.0 pyrazinamide sigE 1364984 p.Ala191Asp missense_variant 1.0 pyrazinamide sigE 1364989 c.577C>T synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim sigE 1364992 p.Pro194Ala missense_variant 0.9 pyrazinamide sigE 1365003 c.591T>C synonymous_variant 1.0 pyrazinamide sigE 1365006 c.594T>C synonymous_variant 1.0 pyrazinamide sigE 1365015 c.603G>C synonymous_variant 1.0 pyrazinamide sigE 1365033 c.621G>A synonymous_variant 0.87 pyrazinamide rrs 1471866 n.21C>T non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1471922 n.78delT non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1471925 n.80T>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1471931 n.87delA non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1471934 n.89A>G non_coding_transcript_exon_variant 1.0 kanamycin capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1471986 n.141C>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472061 n.216A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472075 n.230A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472106 n.261G>T non_coding_transcript_exon_variant 0.98 kanamycin capreomycin streptomycin amikacin rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance capreomycin Not assoc w R streptomycin Uncertain significance amikacin Not assoc w R rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance capreomycin Not assoc w R streptomycin Uncertain significance amikacin Not assoc w R rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472289 n.444T>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472290 n.445C>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1472315 n.470T>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472324 n.479G>C non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin Uncertain significance amikacin rrs 1472325 n.480G>C non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin Uncertain significance amikacin rrs 1472337 n.492C>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472380 n.535G>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.98 kanamycin capreomycin streptomycin amikacin rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472755 n.910G>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472847 n.1002G>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1472860 n.1015C>A non_coding_transcript_exon_variant 1.0 kanamycin capreomycin streptomycin amikacin rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin amikacin Uncertain significance rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance capreomycin Uncertain significance streptomycin Uncertain significance amikacin Uncertain significance rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance linezolid rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance linezolid rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance linezolid rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid Uncertain significance rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid rrl 1473806 n.149C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid rrl 1473813 n.156C>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid Uncertain significance rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1473831 n.174G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1473832 n.175C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.98 capreomycin linezolid Uncertain significance rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid Uncertain significance rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.97 capreomycin linezolid rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid Uncertain significance rrl 1473898 n.241C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1473899 n.242A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474174 n.517A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474181 n.524C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1474183 n.526T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474185 n.528G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1474186 n.529A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474266 n.609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474269 n.612C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474284 n.629dupC non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474292 n.635_644delTTCCTCTCCGinsC non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474303 n.646A>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474306 n.649A>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474387 n.730C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474421 n.764_767delGCGCinsA non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474432 n.775C>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474438 n.781delAinsGT non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474439 n.782A>G non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474446 n.789C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.99 capreomycin linezolid rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid rrl 1474630 n.973T>G non_coding_transcript_exon_variant 0.97 capreomycin linezolid rrl 1474631 n.974G>T non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1474636 n.979A>G non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474639 n.982G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474710 n.1053delTinsACAC non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474718 n.1061A>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474720 n.1065_1066delTG non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid Uncertain significance rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.92 capreomycin linezolid rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475324 n.1667G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475376 n.1719A>C non_coding_transcript_exon_variant 0.98 capreomycin linezolid Uncertain significance rrl 1475380 n.1723C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1475397 n.1740G>A non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1475403 n.1746T>G non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1475406 n.1749T>G non_coding_transcript_exon_variant 0.98 capreomycin linezolid rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.99 capreomycin linezolid rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.99 capreomycin linezolid rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475603 n.1946G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475629 n.1972_1973insT non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.99 capreomycin linezolid rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance linezolid Uncertain significance rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R linezolid Uncertain significance rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance linezolid rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance linezolid rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.95 capreomycin linezolid rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R linezolid Uncertain significance rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance linezolid rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R linezolid Uncertain significance rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R linezolid Uncertain significance rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid Uncertain significance rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance linezolid rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476740 n.3083G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476744 n.3087G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476746 n.3089T>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476755 n.3098G>T non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 1.0 capreomycin linezolid rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 1.0 capreomycin linezolid inhA 1673658 c.-544G>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673660 c.-542C>A upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673664 c.-538A>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673667 c.-535A>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673673 c.-529C>T upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673679 c.-523T>C upstream_gene_variant 1.0 isoniazid Uncertain significance ethionamide Uncertain significance inhA 1673706 c.-496C>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673710 c.-492_-490delCTAinsATC upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673718 c.-484G>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673724 c.-478A>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673730 c.-472C>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673748 c.-454A>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673750 c.-452A>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673755 c.-447G>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673767 c.-435A>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673772 c.-430C>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673778 c.-424C>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673784 c.-418G>A upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673787 c.-415G>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673797 c.-405_-403delGCTinsACC upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673802 c.-400A>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673808 c.-394A>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673955 c.-247G>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673961 c.-241A>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673967 c.-235G>C upstream_gene_variant 0.92 isoniazid ethionamide inhA 1673976 c.-226T>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673985 c.-217C>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1673988 c.-214G>C upstream_gene_variant 1.0 isoniazid ethionamide inhA 1674006 c.-196T>G upstream_gene_variant 1.0 isoniazid ethionamide inhA 1674428 p.Gly76Asp missense_variant 1.0 isoniazid Uncertain significance ethionamide Uncertain significance inhA 1674435 c.234G>C synonymous_variant 0.92 isoniazid ethionamide inhA 1674440 p.Glu80Ala missense_variant 1.0 isoniazid Uncertain significance ethionamide Uncertain significance inhA 1674443 p.Ala81Glu missense_variant 1.0 isoniazid ethionamide inhA 1674450 c.249G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674452 p.Ala84Glu missense_variant 1.0 isoniazid ethionamide inhA 1674471 c.270G>C synonymous_variant 0.94 isoniazid ethionamide inhA 1674480 c.279T>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674483 c.282G>C synonymous_variant 0.94 isoniazid ethionamide inhA 1674486 c.285T>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674489 c.288G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674498 c.297G>C synonymous_variant 0.94 isoniazid ethionamide inhA 1674507 c.306G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674542 p.Ala114Glu missense_variant 1.0 isoniazid ethionamide inhA 1674546 c.345T>C synonymous_variant 0.96 isoniazid ethionamide inhA 1674549 c.348G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674550 p.Ser117Ala missense_variant 0.96 isoniazid ethionamide inhA 1674576 c.375T>C synonymous_variant 0.96 isoniazid ethionamide inhA 1674579 c.378G>C synonymous_variant 0.96 isoniazid ethionamide inhA 1674582 c.381T>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674585 c.384T>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim ethionamide Not assoc w R - Interim inhA 1674589 p.Met130Leu missense_variant 1.0 isoniazid ethionamide inhA 1674600 c.399G>C synonymous_variant 0.96 isoniazid ethionamide inhA 1674601 p.Leu134Val missense_variant 0.96 isoniazid ethionamide inhA 1674621 c.420C>G synonymous_variant 0.96 isoniazid ethionamide inhA 1674624 c.423A>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674627 c.426T>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674628 p.Ser143Gly missense_variant 0.96 isoniazid ethionamide inhA 1674639 c.438C>G synonymous_variant 0.96 isoniazid ethionamide inhA 1674656 p.Ser152Thr missense_variant 0.97 isoniazid ethionamide inhA 1674660 c.459G>C synonymous_variant 0.97 isoniazid ethionamide inhA 1674663 c.462G>C synonymous_variant 0.97 isoniazid ethionamide inhA 1674669 c.468G>T synonymous_variant 0.97 isoniazid ethionamide inhA 1674703 c.502_504delTTGinsCTC synonymous_variant 1.0 isoniazid ethionamide inhA 1674708 c.507G>A synonymous_variant 1.0 isoniazid ethionamide inhA 1674714 c.513C>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674718 c.517_519delAGGinsCGA synonymous_variant 1.0 isoniazid ethionamide inhA 1674726 c.525G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674729 c.528G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674745 p.Tyr182Val missense_variant 1.0 isoniazid ethionamide inhA 1674750 c.549T>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674756 c.555T>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674759 c.558G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674765 c.564C>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674771 c.570C>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674777 c.576C>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674780 c.579T>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674801 c.600T>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674819 c.618G>T synonymous_variant 1.0 isoniazid ethionamide inhA 1674840 c.639C>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674846 p.Ile215Met missense_variant 0.98 isoniazid ethionamide inhA 1674855 c.654C>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim ethionamide inhA 1674858 c.657G>A synonymous_variant 0.98 isoniazid ethionamide inhA 1674870 c.669T>C synonymous_variant 0.96 isoniazid ethionamide inhA 1674876 c.675C>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674879 c.678T>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674883 p.Ile228Leu missense_variant 0.95 isoniazid ethionamide inhA 1674903 c.702T>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674904 p.Ala235Pro missense_variant 1.0 isoniazid ethionamide inhA 1674909 c.708G>C synonymous_variant 1.0 isoniazid ethionamide inhA 1674927 c.726G>C synonymous_variant 0.93 isoniazid ethionamide inhA 1674937 p.Leu246Met missense_variant 0.92 isoniazid ethionamide inhA 1674942 c.741T>G synonymous_variant 1.0 isoniazid ethionamide inhA 1674949 c.748C>T synonymous_variant 0.89 isoniazid ethionamide rpsA 1833557 p.Val6Ile missense_variant 1.0 pyrazinamide rpsA 1833578 p.Val13Ile missense_variant 1.0 pyrazinamide rpsA 1833589 c.48A>T synonymous_variant 1.0 pyrazinamide rpsA 1833595 c.54T>G synonymous_variant 1.0 pyrazinamide rpsA 1833596 p.Ser19Ala missense_variant 1.0 pyrazinamide rpsA 1833616 c.75A>G synonymous_variant 1.0 pyrazinamide rpsA 1833619 c.78A>C synonymous_variant 1.0 pyrazinamide rpsA 1833625 c.84A>G synonymous_variant 1.0 pyrazinamide rpsA 1833628 c.87G>C synonymous_variant 1.0 pyrazinamide rpsA 1833676 c.135A>G synonymous_variant 1.0 pyrazinamide rpsA 1833679 c.138G>C synonymous_variant 1.0 pyrazinamide rpsA 1833685 c.144G>T synonymous_variant 1.0 pyrazinamide rpsA 1833694 c.153G>T synonymous_variant 1.0 pyrazinamide rpsA 1833697 c.156C>G synonymous_variant 1.0 pyrazinamide rpsA 1833709 c.168C>T synonymous_variant 1.0 pyrazinamide rpsA 1833727 c.186G>C synonymous_variant 1.0 pyrazinamide rpsA 1833734 p.Ala65Ser missense_variant 0.96 pyrazinamide rpsA 1833745 c.204G>C synonymous_variant 1.0 pyrazinamide rpsA 1833769 c.228C>G synonymous_variant 1.0 pyrazinamide rpsA 1833772 c.231C>T synonymous_variant 1.0 pyrazinamide rpsA 1833787 c.246C>G synonymous_variant 1.0 pyrazinamide rpsA 1833790 c.249T>C synonymous_variant 0.97 pyrazinamide rpsA 1833793 c.252C>T synonymous_variant 1.0 pyrazinamide rpsA 1833802 c.261A>G synonymous_variant 1.0 pyrazinamide rpsA 1833805 c.264C>T synonymous_variant 1.0 pyrazinamide rpsA 1833808 c.267G>C synonymous_variant 1.0 pyrazinamide rpsA 1833811 c.270G>C synonymous_variant 1.0 pyrazinamide rpsA 1833829 c.288A>G synonymous_variant 1.0 pyrazinamide rpsA 1833832 c.291G>A synonymous_variant 1.0 pyrazinamide rpsA 1833838 c.297G>T synonymous_variant 1.0 pyrazinamide rpsA 1833841 c.300C>G synonymous_variant 1.0 pyrazinamide rpsA 1833847 c.306C>G synonymous_variant 1.0 pyrazinamide rpsA 1833856 c.315A>G synonymous_variant 1.0 pyrazinamide rpsA 1833862 c.321G>T synonymous_variant 0.97 pyrazinamide rpsA 1833868 c.327C>T synonymous_variant 1.0 pyrazinamide rpsA 1833877 c.336C>T synonymous_variant 1.0 pyrazinamide rpsA 1833892 c.351G>A synonymous_variant 1.0 pyrazinamide rpsA 1833894 p.Ala118Glu missense_variant 1.0 pyrazinamide rpsA 1833928 c.387G>C synonymous_variant 1.0 pyrazinamide rpsA 1833949 c.408T>C synonymous_variant 0.97 pyrazinamide rpsA 1833970 c.429G>C synonymous_variant 1.0 pyrazinamide rpsA 1833979 c.438T>C synonymous_variant 1.0 pyrazinamide rpsA 1833988 c.447C>T synonymous_variant 0.97 pyrazinamide rpsA 1833991 c.450C>A synonymous_variant 0.97 pyrazinamide rpsA 1834009 c.468C>T synonymous_variant 0.97 pyrazinamide rpsA 1834012 c.471G>C synonymous_variant 0.97 pyrazinamide rpsA 1834015 c.474G>C synonymous_variant 1.0 pyrazinamide rpsA 1834021 c.480C>T synonymous_variant 1.0 pyrazinamide rpsA 1834030 c.489C>G synonymous_variant 0.97 pyrazinamide rpsA 1834069 c.528G>C synonymous_variant 0.93 pyrazinamide rpsA 1834096 c.555G>C synonymous_variant 0.92 pyrazinamide rpsA 1834099 c.558C>G synonymous_variant 0.92 pyrazinamide rpsA 1834102 c.561T>C synonymous_variant 1.0 pyrazinamide rpsA 1834108 c.567C>G synonymous_variant 0.93 pyrazinamide rpsA 1834150 c.609G>C synonymous_variant 1.0 pyrazinamide rpsA 1834153 c.612_613delTAinsCCAGCTC frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance rpsA 1834157 c.616_621delTTGCAAinsC frameshift_variant&synonymous_variant 1.0 pyrazinamide Uncertain significance rpsA 1834165 c.624A>G synonymous_variant 1.0 pyrazinamide rpsA 1834169 p.Thr210Ala missense_variant 0.95 pyrazinamide Uncertain significance rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim rpsA 1834186 c.645C>G synonymous_variant 1.0 pyrazinamide rpsA 1834189 c.648G>C synonymous_variant 1.0 pyrazinamide rpsA 1834213 c.672G>C synonymous_variant 0.95 pyrazinamide rpsA 1834234 c.693G>C synonymous_variant 0.97 pyrazinamide rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide rpsA 1834279 c.738C>T synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim rpsA 1834297 c.756C>T synonymous_variant 1.0 pyrazinamide rpsA 1834303 c.762T>G synonymous_variant 0.98 pyrazinamide rpsA 1834306 c.765T>C synonymous_variant 1.0 pyrazinamide rpsA 1834348 c.807T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim rpsA 1834366 c.825A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim rpsA 1834375 c.834G>A synonymous_variant 1.0 pyrazinamide rpsA 1834396 c.855G>C synonymous_variant 1.0 pyrazinamide rpsA 1834411 c.870T>C synonymous_variant 1.0 pyrazinamide rpsA 1834423 c.882G>C synonymous_variant 1.0 pyrazinamide rpsA 1834451 c.910T>C synonymous_variant 1.0 pyrazinamide rpsA 1834468 c.927A>G synonymous_variant 1.0 pyrazinamide rpsA 1834474 c.933C>G synonymous_variant 1.0 pyrazinamide rpsA 1834489 c.948T>C synonymous_variant 1.0 pyrazinamide rpsA 1834513 c.972C>G synonymous_variant 0.94 pyrazinamide rpsA 1834520 p.Ala327Ser missense_variant 0.94 pyrazinamide rpsA 1834528 c.987T>C synonymous_variant 1.0 pyrazinamide rpsA 1834540 c.999G>C synonymous_variant 0.93 pyrazinamide rpsA 1834543 c.1002C>G synonymous_variant 0.92 pyrazinamide rpsA 1834546 c.1005T>C synonymous_variant 1.0 pyrazinamide rpsA 1834554 c.1014_1015delTG frameshift_variant 1.0 pyrazinamide Uncertain significance rpsA 1834558 c.1017_1018insAG frameshift_variant 1.0 pyrazinamide Uncertain significance rpsA 1834573 c.1032G>A synonymous_variant 0.96 pyrazinamide rpsA 1834606 c.1065C>T synonymous_variant 1.0 pyrazinamide rpsA 1834609 c.1068T>C synonymous_variant 1.0 pyrazinamide rpsA 1834612 c.1071G>C synonymous_variant 0.95 pyrazinamide rpsA 1834619 c.1078T>C synonymous_variant 0.95 pyrazinamide rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 1.0 pyrazinamide rpsA 1834633 c.1092A>G synonymous_variant 1.0 pyrazinamide rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide rpsA 1834649 p.Thr370Ser missense_variant 0.96 pyrazinamide rpsA 1834663 p.AspProAla374GluAlaTrp missense_variant 1.0 pyrazinamide rpsA 1834690 c.1149T>C synonymous_variant 1.0 pyrazinamide rpsA 1834699 p.Glu386Asp missense_variant 0.95 pyrazinamide rpsA 1834732 c.1191T>C synonymous_variant 1.0 pyrazinamide rpsA 1834738 p.Glu399Asp missense_variant 0.94 pyrazinamide rpsA 1834747 c.1206A>G synonymous_variant 0.94 pyrazinamide rpsA 1834753 c.1212T>C synonymous_variant 1.0 pyrazinamide rpsA 1834756 c.1215G>A synonymous_variant 0.97 pyrazinamide rpsA 1834759 c.1218A>C synonymous_variant 0.97 pyrazinamide rpsA 1834765 c.1224A>G synonymous_variant 1.0 pyrazinamide rpsA 1834774 c.1233C>T synonymous_variant 0.96 pyrazinamide rpsA 1834776 p.Ala412Asp missense_variant 0.96 pyrazinamide rpsA 1834780 c.1239A>G synonymous_variant 1.0 pyrazinamide rpsA 1834786 c.1245A>G synonymous_variant 1.0 pyrazinamide rpsA 1834789 c.1248T>C synonymous_variant 1.0 pyrazinamide rpsA 1834813 c.1272G>C synonymous_variant 1.0 pyrazinamide katG 2155655 p.Lys153Gln missense_variant 0.93 isoniazid Uncertain significance katG 2155661 p.Val151Ile missense_variant 0.56 isoniazid katG 2155676 c.436C>A synonymous_variant 0.41 isoniazid katG 2155696 p.Ala139Val missense_variant 0.55 isoniazid katG 2155716 c.396T>G synonymous_variant 1.0 isoniazid katG 2155728 c.384G>T synonymous_variant 1.0 isoniazid katG 2155740 p.Gly124Pro missense_variant 1.0 isoniazid katG 2155743 c.369G>T synonymous_variant 0.59 isoniazid katG 2155765 p.His116Ser missense_variant 1.0 isoniazid katG 2155769 p.Ile115Val missense_variant 0.68 isoniazid katG 2155770 c.342C>G synonymous_variant 0.68 isoniazid katG 2155782 c.330C>A synonymous_variant 0.71 isoniazid katG 2155785 c.327T>C synonymous_variant 1.0 isoniazid katG 2155794 c.318G>C synonymous_variant 1.0 isoniazid katG 2155806 c.306T>C synonymous_variant 1.0 isoniazid katG 2155809 c.303G>T synonymous_variant 0.9 isoniazid kasA 2517941 c.-174C>G upstream_gene_variant 0.81 isoniazid kasA 2517959 c.-156C>T upstream_gene_variant 0.83 isoniazid kasA 2518747 c.633C>G synonymous_variant 1.0 isoniazid kasA 2519105 p.Cys331Val missense_variant 0.94 isoniazid kasA 2519110 p.Asp332Glu missense_variant 1.0 isoniazid kasA 2519113 p.Gln333His missense_variant 0.95 isoniazid kasA 2519137 c.1023T>G synonymous_variant 1.0 isoniazid kasA 2519161 c.1047G>C synonymous_variant 0.96 isoniazid kasA 2519167 c.1053T>C synonymous_variant 1.0 isoniazid kasA 2519170 c.1056G>C synonymous_variant 0.96 isoniazid kasA 2519179 c.1065G>T synonymous_variant 0.96 isoniazid kasA 2519181 p.Val356Ala missense_variant 0.96 isoniazid kasA 2519185 c.1071C>G synonymous_variant 0.91 isoniazid kasA 2519195 p.Thr361Ala missense_variant 0.9 isoniazid kasA 2519203 c.1089C>G synonymous_variant 0.95 isoniazid kasA 2519209 c.1095C>A synonymous_variant 0.95 isoniazid kasA 2519224 c.1110C>A synonymous_variant 0.94 isoniazid Rv2477c 2782465 c.1578G>A synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782480 c.1563G>A synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782483 c.1560G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782486 c.1557G>A synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782496 p.Asp516Ser missense_variant 0.86 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782501 c.1542T>C synonymous_variant 0.88 kanamycin Not assoc w R - Interim levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim streptomycin rifampicin Not assoc w R - Interim ethambutol amikacin Not assoc w R - Interim Rv2477c 2782528 c.1515G>C synonymous_variant 0.96 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782537 c.1506T>C synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782540 c.1503T>C synonymous_variant 0.96 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782549 c.1494T>C synonymous_variant 0.96 kanamycin levofloxacin moxifloxacin streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Rv2477c 2782555 c.1486_1488delTCGinsAGC synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782558 c.1485T>C synonymous_variant 0.96 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782586 p.Leu486Gln missense_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782591 c.1452T>G synonymous_variant 0.96 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782594 c.1449T>C synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782602 c.1441C>T synonymous_variant 0.91 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782606 p.Gly479Ser missense_variant 0.95 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782612 c.1431T>C synonymous_variant 0.95 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782618 c.1425C>G synonymous_variant 0.95 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782621 c.1422T>C synonymous_variant 0.95 kanamycin levofloxacin moxifloxacin streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Rv2477c 2782624 c.1419G>C synonymous_variant 0.95 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782633 c.1410G>C synonymous_variant 0.95 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782639 c.1404A>G synonymous_variant 0.95 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782651 c.1392T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782669 c.1374A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782675 c.1368G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782680 c.1363T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782684 c.1359T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782695 c.1348A>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782705 c.1338G>T synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782738 c.1305C>T synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782744 c.1299A>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782750 c.1293T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782753 c.1290G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782759 c.1284A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782771 c.1272C>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782774 c.1269G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782777 c.1266A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782786 c.1257A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782790 p.Thr418Asn missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782792 c.1251A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782803 p.Gln414Glu missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782807 c.1236T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782816 c.1227T>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782822 c.1221G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782828 c.1215T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin Not assoc w R - Interim streptomycin Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Rv2477c 2782840 c.1203C>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782847 p.Arg399Lys missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782852 c.1191T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782861 c.1182T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782869 p.Ala392Thr missense_variant 1.0 kanamycin Uncertain significance levofloxacin Uncertain significance moxifloxacin Uncertain significance streptomycin rifampicin Uncertain significance ethambutol Uncertain significance amikacin Uncertain significance Rv2477c 2782876 c.1167G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782882 c.1161T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782894 c.1149C>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782909 c.1134C>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Rv2477c 2782913 p.Ser377Thr missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782924 c.1119G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782927 p.Thr372Glu missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782936 c.1107G>T synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782948 c.1095A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782957 c.1086A>G synonymous_variant 1.0 kanamycin Not assoc w R - Interim levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim streptomycin Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Not assoc w R - Interim Rv2477c 2782969 c.1074A>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782972 c.1071G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782981 c.1062G>A synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2782984 c.1059T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783002 c.1041T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783008 c.1035C>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783014 p.Ser343Thr missense_variant 0.9 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783068 p.Asp325Glu missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783077 c.966T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783086 c.957C>T synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783092 c.951A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Rv2477c 2783095 c.948C>G synonymous_variant 1.0 kanamycin Not assoc w R - Interim levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim streptomycin Not assoc w R - Interim rifampicin Not assoc w R ethambutol Not assoc w R - Interim amikacin Not assoc w R - Interim Rv2477c 2783101 c.942G>C synonymous_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783116 c.927T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783140 c.903C>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783149 c.894G>C synonymous_variant 1.0 kanamycin Not assoc w R - Interim levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim streptomycin rifampicin Not assoc w R - Interim ethambutol amikacin Not assoc w R - Interim Rv2477c 2783158 c.885A>T synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783185 c.858G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783192 p.Ser284Asn missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783194 c.849A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783215 c.828G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783218 c.825C>G synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783410 c.633G>C synonymous_variant 0.92 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783425 p.Pro206Lys missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783437 c.606G>C synonymous_variant 0.9 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783456 p.Gln196Leu missense_variant 0.9 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783464 c.579A>G synonymous_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783467 c.576G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783473 c.570A>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783485 c.558G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783499 c.544T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783502 c.541T>C synonymous_variant 1.0 kanamycin Not assoc w R - Interim levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim streptomycin Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Not assoc w R - Interim Rv2477c 2783506 c.537C>T synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783512 c.531A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783520 c.523T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Rv2477c 2783524 c.519G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783527 c.516A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783542 c.501G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783548 p.Arg165Lys missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783554 c.489C>T synonymous_variant 1.0 kanamycin Not assoc w R - Interim levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Not assoc w R - Interim Rv2477c 2783557 c.486T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783563 c.480A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783568 p.Asn159His missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783572 c.471A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783586 p.Ala153Pro missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783593 c.450T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783605 c.438T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783611 c.432C>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783626 p.Ala139Ser missense_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783634 p.Leu137Ile missense_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783641 c.402G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783651 p.His131Ala missense_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783656 c.387G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783659 c.384A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783665 c.378A>G synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783668 c.375G>T synonymous_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783672 p.Arg124Lys missense_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783674 c.369T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783683 p.Glu120Asp missense_variant 1.0 kanamycin Uncertain significance levofloxacin Uncertain significance moxifloxacin Uncertain significance streptomycin Uncertain significance rifampicin Uncertain significance ethambutol Uncertain significance amikacin Uncertain significance Rv2477c 2783718 c.325T>C synonymous_variant 0.83 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783872 c.171G>C synonymous_variant 0.7 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783877 p.Lys56Gln missense_variant 0.73 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783884 c.159T>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783929 c.114C>A synonymous_variant 0.94 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783938 c.105T>C synonymous_variant 0.94 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783947 c.96C>G synonymous_variant 0.94 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783957 p.Tyr29Leu missense_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783962 p.Ser27Asn missense_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783967 c.76T>C synonymous_variant 0.93 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783971 c.72G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783980 c.63C>T synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783986 c.57G>C synonymous_variant 1.0 kanamycin levofloxacin moxifloxacin streptomycin rifampicin ethambutol amikacin Rv2477c 2783992 c.51T>C synonymous_variant 1.0 kanamycin Not assoc w R - Interim levofloxacin Not assoc w R - Interim moxifloxacin streptomycin Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim amikacin Rv2752c 3065055 c.1137T>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065058 c.1134C>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065061 c.1131C>T synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065070 c.1122C>T synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim Rv2752c 3065073 c.1119C>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim Rv2752c 3065076 c.1116T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065087 c.1105A>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid Not assoc w R - Interim rifampicin ethambutol Rv2752c 3065088 c.1104A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim moxifloxacin isoniazid Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim Rv2752c 3065094 c.1098C>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065097 c.1095C>T synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065109 c.1081_1083delAGAinsCGC synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065487 c.705T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065490 c.702A>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065499 c.693A>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065505 c.687C>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065508 c.684T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim Rv2752c 3065511 c.681G>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065514 p.Ile226Met missense_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065531 p.Thr221Ala missense_variant 1.0 levofloxacin moxifloxacin isoniazid Uncertain significance rifampicin Uncertain significance ethambutol Uncertain significance Rv2752c 3065532 c.660A>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065535 c.657C>G synonymous_variant 0.94 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065538 c.654G>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065541 c.651A>G synonymous_variant 0.95 levofloxacin moxifloxacin isoniazid Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim Rv2752c 3065547 c.645A>G synonymous_variant 0.96 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065553 c.639A>G synonymous_variant 1.0 levofloxacin moxifloxacin Not assoc w R - Interim isoniazid Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim Rv2752c 3065576 p.Ala206Ser missense_variant 0.96 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065580 c.612G>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065583 c.609G>C synonymous_variant 0.96 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065595 p.Leu199Phe missense_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065604 c.588G>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065612 p.Thr194Ala missense_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065622 c.570G>C synonymous_variant 0.95 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065631 c.561C>G synonymous_variant 0.94 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065634 c.558G>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065637 c.555A>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065649 c.541_543delCGTinsAGG synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol Rv2752c 3065661 c.531A>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid rifampicin ethambutol thyX 3067316 c.630A>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067325 c.621A>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067330 p.Val206Leu missense_variant 1.0 para-aminosalicylic_acid thyX 3067331 c.615C>T synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067337 c.609C>T synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067355 c.591A>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067373 c.573C>G synonymous_variant 0.94 para-aminosalicylic_acid thyX 3067385 c.561C>G synonymous_variant 0.94 para-aminosalicylic_acid thyX 3067394 c.552G>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067400 c.546C>G synonymous_variant 0.89 para-aminosalicylic_acid thyX 3067406 c.540A>G synonymous_variant 0.84 para-aminosalicylic_acid thyX 3067427 c.519G>C synonymous_variant 0.8 para-aminosalicylic_acid thyX 3067439 c.507A>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067612 p.Lys112Gln missense_variant 1.0 para-aminosalicylic_acid thyX 3067619 c.327A>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067634 c.312C>G synonymous_variant 0.92 para-aminosalicylic_acid thyX 3067652 c.294T>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067661 c.283_285delCGCinsAGG synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067682 c.264G>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067685 c.261A>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067694 c.252G>A synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067715 c.229_231delAGCinsTCG synonymous_variant 0.88 para-aminosalicylic_acid thyX 3067718 c.228C>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067721 c.225T>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067727 c.219A>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067742 c.204A>T synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067760 c.186G>T synonymous_variant 0.85 para-aminosalicylic_acid thyX 3067763 p.Leu61Val missense_variant 0.85 para-aminosalicylic_acid thyX 3067770 p.Gly59Ala missense_variant 0.85 para-aminosalicylic_acid thyX 3067775 c.171C>T synonymous_variant 0.85 para-aminosalicylic_acid thyX 3067781 c.165C>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067787 p.Lys53Arg missense_variant 1.0 para-aminosalicylic_acid thyX 3067790 c.156C>G synonymous_variant 0.85 para-aminosalicylic_acid thyX 3067793 c.153T>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067803 c.142_143delTCinsAG synonymous_variant 0.88 para-aminosalicylic_acid thyX 3067814 c.132T>C synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067820 c.126C>G synonymous_variant 0.94 para-aminosalicylic_acid thyX 3067823 c.123G>C synonymous_variant 0.94 para-aminosalicylic_acid thyX 3067850 c.96A>G synonymous_variant 1.0 para-aminosalicylic_acid thyX 3067853 c.93C>G synonymous_variant 0.9 para-aminosalicylic_acid thyX 3067869 p.Thr26Ser missense_variant 1.0 para-aminosalicylic_acid thyA 3073863 c.609T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073881 c.591C>G synonymous_variant 0.92 para-aminosalicylic_acid thyA 3073884 c.588C>G synonymous_variant 0.92 para-aminosalicylic_acid thyA 3073888 p.Ser195Gly missense_variant 0.92 para-aminosalicylic_acid thyA 3073892 c.580T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073902 c.570C>G synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073920 c.552C>G synonymous_variant 0.9 para-aminosalicylic_acid thyA 3073925 c.547T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073929 c.543T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073953 c.519T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073956 c.516G>C synonymous_variant 0.9 para-aminosalicylic_acid thyA 3073959 c.513T>C synonymous_variant 0.9 para-aminosalicylic_acid thyA 3073977 c.495A>G synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073983 c.489C>G synonymous_variant 0.89 para-aminosalicylic_acid thyA 3073989 c.483T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3073992 c.480C>T synonymous_variant 0.9 para-aminosalicylic_acid thyA 3074004 c.468T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074013 c.459C>T synonymous_variant 0.88 para-aminosalicylic_acid thyA 3074031 c.441T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074034 c.438T>C synonymous_variant 0.92 para-aminosalicylic_acid thyA 3074037 c.435C>G synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074053 p.Arg140Gln missense_variant 0.9 para-aminosalicylic_acid thyA 3074056 p.Glu139Pro missense_variant 1.0 para-aminosalicylic_acid thyA 3074061 c.411A>G synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074076 c.396C>G synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074082 c.390G>C synonymous_variant 0.94 para-aminosalicylic_acid thyA 3074089 p.Ile128Asn missense_variant 0.92 para-aminosalicylic_acid thyA 3074094 c.378G>C synonymous_variant 0.92 para-aminosalicylic_acid thyA 3074097 c.375C>G synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074100 c.372T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074106 c.366T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074108 c.361_363delACC conservative_inframe_deletion 1.0 para-aminosalicylic_acid thyA 3074115 c.356_357insCAA disruptive_inframe_insertion 1.0 para-aminosalicylic_acid thyA 3074120 c.352T>C synonymous_variant 1.0 para-aminosalicylic_acid thyA 3074121 p.Asp117Glu missense_variant 1.0 para-aminosalicylic_acid ald 3087251 c.432T>C synonymous_variant 0.92 cycloserine ald 3087257 c.438T>C synonymous_variant 0.92 cycloserine ald 3087266 c.447G>C synonymous_variant 0.93 cycloserine ald 3087272 c.453A>C synonymous_variant 0.93 cycloserine ald 3087274 p.Thr152Ser missense_variant 0.93 cycloserine ald 3087278 p.Gln153His missense_variant 0.93 cycloserine ald 3087281 c.462G>C synonymous_variant 0.93 cycloserine ald 3087305 c.486G>C synonymous_variant 1.0 cycloserine lpqB 3624351 p.Ala187Val missense_variant 1.0 rifampicin Uncertain significance bedaquiline lpqB 3624355 p.Val186Leu missense_variant 1.0 rifampicin bedaquiline lpqB 3624359 c.552C>T synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624365 c.546T>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624371 c.540T>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624392 c.519C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim bedaquiline Not assoc w R - Interim lpqB 3624401 c.510C>T synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624404 c.507G>C synonymous_variant 0.8 rifampicin bedaquiline lpqB 3624412 p.Asn167His missense_variant 0.8 rifampicin bedaquiline lpqB 3624413 c.498C>G synonymous_variant 0.8 rifampicin bedaquiline lpqB 3624422 c.489G>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624425 p.Glu162Ala missense_variant 1.0 rifampicin bedaquiline lpqB 3624428 c.483A>G synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624452 c.459T>G synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624464 c.447A>G synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624467 c.444C>A synonymous_variant 0.79 rifampicin bedaquiline lpqB 3624470 c.441T>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624629 c.282G>A synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624632 c.279G>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624637 p.His92Asn missense_variant 1.0 rifampicin bedaquiline lpqB 3624646 c.265T>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624649 c.262T>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624673 p.Ala80Thr missense_variant 0.93 rifampicin bedaquiline lpqB 3624675 p.Asn79Ser missense_variant 0.93 rifampicin bedaquiline lpqB 3624680 c.231T>C synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624683 c.228G>C synonymous_variant 0.93 rifampicin bedaquiline lpqB 3624719 c.192C>T synonymous_variant 0.93 rifampicin bedaquiline lpqB 3624722 c.189C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline Not assoc w R - Interim lpqB 3624728 c.183C>T synonymous_variant 1.0 rifampicin bedaquiline lpqB 3624734 c.177A>T synonymous_variant 0.93 rifampicin bedaquiline lpqB 3624749 c.162G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 1.0 rifampicin bedaquiline mtrB 3625040 p.Thr525Ser missense_variant 0.9 rifampicin bedaquiline mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R bedaquiline Uncertain significance lpqB 3625069 c.-159T>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625072 c.-162G>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625075 c.-165G>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625078 c.-168G>C upstream_gene_variant 0.94 rifampicin bedaquiline mtrB 3625095 p.Glu507Lys missense_variant 0.96 rifampicin bedaquiline lpqB 3625102 c.-192A>G upstream_gene_variant 0.97 rifampicin bedaquiline lpqB 3625117 c.-207T>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625123 c.-213T>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625134 c.-224T>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625135 c.-225A>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625141 c.-231T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625149 p.Val489Ile missense_variant 1.0 rifampicin bedaquiline lpqB 3625161 c.-251T>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625162 c.-252T>G upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625168 c.-258G>T upstream_gene_variant 0.98 rifampicin bedaquiline lpqB 3625189 c.-279A>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625195 c.-285A>G upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625198 c.-288C>G upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625201 c.-291T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625206 p.Ser470Ala missense_variant 0.98 rifampicin bedaquiline mtrB 3625222 c.1392T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim bedaquiline lpqB 3625243 c.-333T>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625246 c.-336G>C upstream_gene_variant 0.96 rifampicin bedaquiline mtrB 3625252 c.1362G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim bedaquiline lpqB 3625255 c.-345T>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625267 c.1347T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline lpqB 3625270 c.-360G>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625276 c.-366C>G upstream_gene_variant 0.94 rifampicin bedaquiline lpqB 3625279 c.-369C>G upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625285 c.-375G>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625291 p.Glu441Val missense_variant 1.0 rifampicin bedaquiline mtrB 3625312 p.Arg434His missense_variant 0.92 rifampicin bedaquiline lpqB 3625315 c.-405G>C upstream_gene_variant 0.96 rifampicin bedaquiline mtrB 3625321 c.1293A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim bedaquiline Not assoc w R - Interim mtrB 3625325 p.His430Arg missense_variant 0.91 rifampicin bedaquiline lpqB 3625345 c.-435T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625351 c.1263T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline lpqB 3625357 c.-447T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625656 c.958T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline Not assoc w R - Interim lpqB 3625663 c.-753G>C upstream_gene_variant 1.0 rifampicin bedaquiline lpqB 3625672 c.-762G>C upstream_gene_variant 0.94 rifampicin bedaquiline lpqB 3625675 c.-765G>C upstream_gene_variant 0.94 rifampicin bedaquiline lpqB 3625678 c.-768C>G upstream_gene_variant 0.89 rifampicin bedaquiline lpqB 3625690 c.-780T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625729 c.885A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3625735 c.879C>A synonymous_variant 0.97 rifampicin Not assoc w R - Interim bedaquiline mtrB 3625744 c.870G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim bedaquiline mtrB 3625747 c.867G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim bedaquiline mtrB 3625750 c.864G>A synonymous_variant 0.97 rifampicin Not assoc w R - Interim bedaquiline mtrB 3625755 p.Ala287Thr missense_variant 1.0 rifampicin Uncertain significance bedaquiline lpqB 3625762 c.-852A>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3625766 p.Ser283His missense_variant 0.92 rifampicin bedaquiline mtrB 3625774 c.840G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim bedaquiline lpqB 3625801 c.-891G>C upstream_gene_variant 0.91 rifampicin bedaquiline lpqB 3625804 c.-896_-894delAGGinsCGA upstream_gene_variant 0.9 rifampicin bedaquiline mtrB 3625837 c.777C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3625845 p.Ser257Thr missense_variant 0.87 rifampicin bedaquiline lpqB 3625846 c.-936G>C upstream_gene_variant 0.85 rifampicin bedaquiline lpqB 3625849 c.-939T>C upstream_gene_variant 0.86 rifampicin bedaquiline lpqB 3625852 c.-942A>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626684 c.-71G>A upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3626711 p.Thr213Gln missense_variant 1.0 rifampicin bedaquiline mtrB 3626723 c.-110C>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626726 c.-113T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626732 c.-119A>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626750 c.-137T>A upstream_gene_variant 0.95 rifampicin bedaquiline mtrB 3626773 c.-160C>T upstream_gene_variant 0.93 rifampicin bedaquiline mtrB 3626774 c.-163_-161delAGGinsCGT upstream_gene_variant 0.97 rifampicin bedaquiline mtrB 3626780 c.-167T>C upstream_gene_variant 0.98 rifampicin bedaquiline mtrB 3626786 c.-173A>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626792 c.-179G>C upstream_gene_variant 0.94 rifampicin bedaquiline mtrA 3626804 c.546A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrA 3626846 c.504G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3626858 c.-245A>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626861 c.-248C>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626866 c.-253T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626876 c.-263A>G upstream_gene_variant 0.96 rifampicin bedaquiline mtrB 3626885 c.-272A>G upstream_gene_variant 0.96 rifampicin bedaquiline mtrB 3626890 c.-277T>C upstream_gene_variant 0.96 rifampicin bedaquiline mtrA 3626906 p.Asn148Gln missense_variant 0.95 rifampicin bedaquiline mtrA 3626909 c.441C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim bedaquiline mtrA 3626912 c.438T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3626930 c.-317A>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3626939 p.Glu137Asp missense_variant 1.0 rifampicin bedaquiline mtrB 3626942 c.-329A>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3626957 c.-344G>C upstream_gene_variant 0.94 rifampicin bedaquiline mtrA 3626969 c.381C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim bedaquiline Not assoc w R - Interim mtrB 3626972 c.-359A>G upstream_gene_variant 0.91 rifampicin bedaquiline mtrA 3626978 p.Asp124Glu missense_variant 0.91 rifampicin Uncertain significance bedaquiline mtrB 3626987 c.-374C>G upstream_gene_variant 0.93 rifampicin bedaquiline mtrB 3626996 c.-383G>C upstream_gene_variant 0.93 rifampicin bedaquiline mtrB 3626999 c.-386G>T upstream_gene_variant 0.95 rifampicin bedaquiline mtrB 3627008 c.-395G>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627011 c.-398T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3627041 p.Ile103Val missense_variant 0.94 rifampicin bedaquiline mtrB 3627059 c.-446G>C upstream_gene_variant 0.94 rifampicin bedaquiline mtrB 3627062 c.-449G>A upstream_gene_variant 0.94 rifampicin bedaquiline mtrA 3627068 c.282T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3627071 c.-458G>C upstream_gene_variant 0.94 rifampicin bedaquiline mtrA 3627080 c.270T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3627083 c.-470G>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3627098 c.252A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3627104 c.-491C>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3627119 c.231T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3627122 c.-509T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627128 c.-515T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627131 c.-518C>G upstream_gene_variant 0.98 rifampicin bedaquiline mtrB 3627139 c.-526T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627143 c.-530G>C upstream_gene_variant 0.98 rifampicin bedaquiline mtrB 3627167 c.-554T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627181 c.-568T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627182 c.-569T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3627187 c.163T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim bedaquiline mtrB 3627188 c.-577_-575delTTAinsCTG upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627209 c.-596G>A upstream_gene_variant 0.98 rifampicin bedaquiline mtrB 3627218 c.-605G>C upstream_gene_variant 0.96 rifampicin bedaquiline mtrB 3627227 c.-614T>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627233 c.-620T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627236 c.-623T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3627242 c.108C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim bedaquiline mtrB 3627251 c.-638G>C upstream_gene_variant 0.95 rifampicin bedaquiline mtrB 3627263 c.-650C>A upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627266 c.-653A>G upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627269 c.-656G>C upstream_gene_variant 0.94 rifampicin bedaquiline mtrB 3627272 c.-659G>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627296 c.-683T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627299 c.-688_-686delTTGinsCTC upstream_gene_variant 1.0 rifampicin bedaquiline mtrA 3627307 p.Ala15Pro missense_variant 0.94 rifampicin bedaquiline mtrB 3627317 c.-704T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627320 c.-707C>A upstream_gene_variant 0.92 rifampicin bedaquiline mtrB 3627325 c.-712T>C upstream_gene_variant 1.0 rifampicin bedaquiline mtrB 3627326 c.-713T>C upstream_gene_variant 0.85 rifampicin bedaquiline rpoA 3877545 c.963G>C synonymous_variant 0.8 rifampicin rpoA 3877548 c.960C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim rpoA 3877554 c.954G>C synonymous_variant 0.8 rifampicin rpoA 3877557 c.951C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877560 c.948C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim rpoA 3877569 p.Pro313Ala missense_variant 0.85 rifampicin rpoA 3877587 c.921A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877593 c.915C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim rpoA 3877638 c.870T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877647 c.861C>T synonymous_variant 0.91 rifampicin rpoA 3877656 c.852T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877662 c.846C>T synonymous_variant 0.96 rifampicin rpoA 3877668 c.840A>G synonymous_variant 1.0 rifampicin rpoA 3877671 c.837C>G synonymous_variant 0.96 rifampicin rpoA 3877677 c.831G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877680 c.828G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877686 c.822A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877692 c.816G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877704 c.804G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoA 3877710 c.798C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoA 3877731 c.777G>T synonymous_variant 0.96 rifampicin rpoA 3877743 c.765T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877764 c.744C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877770 p.Ser246His missense_variant 0.97 rifampicin rpoA 3877776 p.Ile244Ala missense_variant 1.0 rifampicin rpoA 3877779 p.His243Gln missense_variant 0.97 rifampicin Uncertain significance rpoA 3877818 c.690A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877839 c.669G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877848 c.660C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoA 3877875 c.633T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877881 c.627G>C synonymous_variant 0.97 rifampicin rpoA 3877893 c.615C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoA 3877900 p.Ser203Thr missense_variant 1.0 rifampicin rpoA 3877905 c.603A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3877908 c.600T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim rpoA 3877920 c.588G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim rpoA 3877926 c.582G>C synonymous_variant 0.96 rifampicin rpoA 3877962 c.546G>C synonymous_variant 1.0 rifampicin rpoA 3877968 c.540C>G synonymous_variant 0.97 rifampicin rpoA 3877971 p.Asp179Glu missense_variant 0.97 rifampicin Uncertain significance rpoA 3877983 c.525C>T synonymous_variant 0.96 rifampicin rpoA 3877986 c.522G>C synonymous_variant 1.0 rifampicin rpoA 3877989 c.519A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878010 c.498C>G synonymous_variant 0.92 rifampicin rpoA 3878103 c.405A>G synonymous_variant 1.0 rifampicin rpoA 3878118 c.390T>C synonymous_variant 1.0 rifampicin rpoA 3878124 c.384G>C synonymous_variant 0.94 rifampicin rpoA 3878127 c.381G>C synonymous_variant 0.94 rifampicin rpoA 3878142 p.Gly122Glu missense_variant 0.97 rifampicin rpoA 3878157 c.351C>G synonymous_variant 0.95 rifampicin rpoA 3878175 c.333G>C synonymous_variant 0.98 rifampicin rpoA 3878187 c.321C>G synonymous_variant 1.0 rifampicin rpoA 3878193 c.315T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878202 c.306G>C synonymous_variant 1.0 rifampicin rpoA 3878205 c.303T>A synonymous_variant 0.98 rifampicin rpoA 3878217 c.291A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878247 c.261G>C synonymous_variant 1.0 rifampicin rpoA 3878253 c.255G>C synonymous_variant 1.0 rifampicin rpoA 3878259 c.249G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878264 p.Ser82Gly missense_variant 1.0 rifampicin rpoA 3878271 c.237T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878283 p.Glu75Asp missense_variant 1.0 rifampicin Uncertain significance rpoA 3878292 c.216T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878298 c.210A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878310 c.198G>C synonymous_variant 1.0 rifampicin rpoA 3878313 c.195G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878322 c.186A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878331 c.177A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878337 c.171T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim rpoA 3878346 c.162T>C synonymous_variant 1.0 rifampicin rpoA 3878364 c.144A>C synonymous_variant 1.0 rifampicin rpoA 3878367 c.141C>G synonymous_variant 1.0 rifampicin rpoA 3879073 c.-566A>G upstream_gene_variant 0.85 rifampicin rpoA 3879079 c.-572A>C upstream_gene_variant 0.92 rifampicin rpoA 3879088 c.-581A>C upstream_gene_variant 0.93 rifampicin rpoA 3879094 c.-587T>C upstream_gene_variant 0.93 rifampicin rpoA 3879121 c.-616_-614delCTTinsACC upstream_gene_variant 0.93 rifampicin rpoA 3879124 c.-618_-617delTGinsGC upstream_gene_variant 0.81 rifampicin rpoA 3879127 c.-620T>C upstream_gene_variant 0.94 rifampicin rpoA 3879136 c.-629A>G upstream_gene_variant 0.93 rifampicin rpoA 3879151 c.-644C>T upstream_gene_variant 0.87 rifampicin rpoA 3879154 c.-647T>C upstream_gene_variant 0.93 rifampicin rpoA 3879160 c.-653A>G upstream_gene_variant 0.93 rifampicin rpoA 3879178 c.-671T>C upstream_gene_variant 0.93 rifampicin rpoA 3879182 c.-675A>G upstream_gene_variant 0.87 rifampicin ddn 3986616 c.-228_-227delAGinsGC upstream_gene_variant 0.89 pretomanid delamanid ddn 3986636 c.-208C>G upstream_gene_variant 0.92 pretomanid delamanid ddn 3986648 c.-196C>G upstream_gene_variant 1.0 pretomanid delamanid ddn 3986659 c.-185A>G upstream_gene_variant 0.94 pretomanid delamanid ddn 3986661 c.-183C>A upstream_gene_variant 0.94 pretomanid delamanid ddn 3986664 c.-180A>G upstream_gene_variant 0.94 pretomanid delamanid ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 1.0 pretomanid delamanid ddn 3986690 c.-154C>G upstream_gene_variant 1.0 pretomanid delamanid ddn 3986696 c.-148G>C upstream_gene_variant 1.0 pretomanid delamanid clpC1 4038278 c.2427T>C synonymous_variant 1.0 pyrazinamide clpC1 4038290 p.Asp805Glu missense_variant 0.88 pyrazinamide clpC1 4038293 c.2412G>C synonymous_variant 1.0 pyrazinamide clpC1 4038308 p.Val799Leu missense_variant 1.0 pyrazinamide clpC1 4038317 c.2388G>C synonymous_variant 1.0 pyrazinamide clpC1 4038320 c.2385G>A synonymous_variant 0.89 pyrazinamide clpC1 4038329 c.2376G>A synonymous_variant 0.9 pyrazinamide clpC1 4038350 c.2355C>G synonymous_variant 0.87 pyrazinamide clpC1 4038354 p.Gln784Ala missense_variant 0.9 pyrazinamide clpC1 4038356 c.2349T>C synonymous_variant 1.0 pyrazinamide clpC1 4038359 c.2346A>G synonymous_variant 1.0 pyrazinamide clpC1 4038368 c.2337T>C synonymous_variant 1.0 pyrazinamide clpC1 4038380 c.2325C>G synonymous_variant 0.92 pyrazinamide clpC1 4038383 c.2322G>C synonymous_variant 0.92 pyrazinamide clpC1 4038388 c.2317T>C synonymous_variant 1.0 pyrazinamide clpC1 4038395 c.2310C>G synonymous_variant 0.92 pyrazinamide clpC1 4038398 c.2307G>C synonymous_variant 1.0 pyrazinamide clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4038416 c.2289C>G synonymous_variant 0.82 pyrazinamide clpC1 4038419 c.2286T>C synonymous_variant 1.0 pyrazinamide clpC1 4038436 p.Ala757Ser missense_variant 0.75 pyrazinamide clpC1 4038444 p.Ala754Lys missense_variant 1.0 pyrazinamide clpC1 4038519 p.Arg729Lys missense_variant 0.83 pyrazinamide clpC1 4038530 p.Glu725Asp missense_variant 1.0 pyrazinamide clpC1 4038533 p.Arg724Gln missense_variant 0.83 pyrazinamide clpC1 4038536 c.2169C>G synonymous_variant 1.0 pyrazinamide clpC1 4038551 c.2154C>G synonymous_variant 0.81 pyrazinamide clpC1 4038587 c.2118C>T synonymous_variant 0.94 pyrazinamide clpC1 4038596 c.2109A>G synonymous_variant 1.0 pyrazinamide clpC1 4038605 c.2100G>A synonymous_variant 0.94 pyrazinamide clpC1 4038613 p.Asn698His missense_variant 0.94 pyrazinamide clpC1 4038614 c.2091C>T synonymous_variant 0.94 pyrazinamide clpC1 4038623 c.2082A>G synonymous_variant 1.0 pyrazinamide clpC1 4038640 p.Asp689Asn missense_variant 1.0 pyrazinamide clpC1 4038740 c.1965G>C synonymous_variant 0.9 pyrazinamide clpC1 4038755 c.1950G>C synonymous_variant 1.0 pyrazinamide clpC1 4038764 c.1941C>G synonymous_variant 0.71 pyrazinamide clpC1 4038767 c.1938G>C synonymous_variant 0.75 pyrazinamide clpC1 4038770 c.1935C>T synonymous_variant 0.71 pyrazinamide clpC1 4038773 c.1932T>C synonymous_variant 1.0 pyrazinamide clpC1 4038782 c.1923G>C synonymous_variant 0.95 pyrazinamide clpC1 4038791 c.1914G>C synonymous_variant 0.78 pyrazinamide clpC1 4038812 c.1893T>C synonymous_variant 1.0 pyrazinamide clpC1 4038815 c.1890G>C synonymous_variant 0.96 pyrazinamide clpC1 4038839 c.1866G>C synonymous_variant 0.89 pyrazinamide clpC1 4038845 c.1860G>C synonymous_variant 0.89 pyrazinamide clpC1 4038860 c.1845G>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4038890 c.1815G>A synonymous_variant 0.95 pyrazinamide clpC1 4038905 c.1800A>G synonymous_variant 0.98 pyrazinamide clpC1 4038908 c.1797C>G synonymous_variant 1.0 pyrazinamide clpC1 4038911 c.1794G>T synonymous_variant 0.98 pyrazinamide clpC1 4038914 c.1791G>C synonymous_variant 1.0 pyrazinamide clpC1 4038917 c.1788C>T synonymous_variant 0.95 pyrazinamide clpC1 4038923 c.1782A>G synonymous_variant 1.0 pyrazinamide clpC1 4038953 c.1752A>G synonymous_variant 1.0 pyrazinamide clpC1 4038956 c.1749T>C synonymous_variant 1.0 pyrazinamide clpC1 4038965 c.1740T>C synonymous_variant 1.0 pyrazinamide clpC1 4038971 c.1734T>C synonymous_variant 1.0 pyrazinamide clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4038989 c.1716T>C synonymous_variant 1.0 pyrazinamide clpC1 4038997 c.1708T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4039004 c.1701C>G synonymous_variant 0.91 pyrazinamide clpC1 4039022 c.1683A>G synonymous_variant 1.0 pyrazinamide clpC1 4039064 c.1641C>G synonymous_variant 0.93 pyrazinamide clpC1 4039073 c.1632C>T synonymous_variant 1.0 pyrazinamide clpC1 4039082 c.1623C>T synonymous_variant 0.87 pyrazinamide clpC1 4039085 c.1620A>G synonymous_variant 1.0 pyrazinamide clpC1 4039091 c.1614G>T synonymous_variant 0.86 pyrazinamide clpC1 4039097 c.1608G>T synonymous_variant 1.0 pyrazinamide clpC1 4039103 c.1602T>C synonymous_variant 0.97 pyrazinamide clpC1 4039106 c.1599G>C synonymous_variant 1.0 pyrazinamide clpC1 4039112 c.1593C>G synonymous_variant 1.0 pyrazinamide clpC1 4039121 c.1584T>C synonymous_variant 1.0 pyrazinamide clpC1 4039136 c.1569C>T synonymous_variant 0.9 pyrazinamide clpC1 4039142 c.1563A>G synonymous_variant 1.0 pyrazinamide clpC1 4039145 c.1560G>C synonymous_variant 1.0 pyrazinamide clpC1 4039169 p.Glu512Asp missense_variant 1.0 pyrazinamide clpC1 4039172 c.1533A>G synonymous_variant 1.0 pyrazinamide clpC1 4039178 c.1527G>C synonymous_variant 1.0 pyrazinamide clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.86 pyrazinamide clpC1 4039187 c.1518G>T synonymous_variant 0.96 pyrazinamide clpC1 4039190 c.1515C>G synonymous_variant 0.97 pyrazinamide clpC1 4039199 p.Ala502Glu missense_variant 0.88 pyrazinamide clpC1 4039208 c.1497C>G synonymous_variant 0.94 pyrazinamide clpC1 4039226 c.1479T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4039244 c.1461G>C synonymous_variant 0.94 pyrazinamide clpC1 4039271 c.1434G>A synonymous_variant 0.94 pyrazinamide clpC1 4039277 c.1428C>G synonymous_variant 0.98 pyrazinamide clpC1 4039280 c.1425G>C synonymous_variant 0.91 pyrazinamide clpC1 4039283 c.1422C>T synonymous_variant 0.93 pyrazinamide clpC1 4039286 c.1419T>C synonymous_variant 1.0 pyrazinamide clpC1 4039298 c.1407T>C synonymous_variant 1.0 pyrazinamide clpC1 4039310 c.1395A>G synonymous_variant 0.96 pyrazinamide clpC1 4039313 c.1392C>T synonymous_variant 0.96 pyrazinamide clpC1 4039319 c.1386T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4039322 c.1383T>C synonymous_variant 1.0 pyrazinamide clpC1 4039328 c.1377A>G synonymous_variant 1.0 pyrazinamide clpC1 4039334 c.1371G>C synonymous_variant 0.98 pyrazinamide clpC1 4039337 c.1368A>C synonymous_variant 1.0 pyrazinamide clpC1 4039347 p.Arg453Lys missense_variant 0.98 pyrazinamide clpC1 4039382 c.1323C>G synonymous_variant 0.98 pyrazinamide clpC1 4039391 c.1314T>G synonymous_variant 1.0 pyrazinamide clpC1 4039394 c.1311G>C synonymous_variant 0.98 pyrazinamide clpC1 4039397 c.1308A>G synonymous_variant 0.98 pyrazinamide clpC1 4039409 c.1296T>C synonymous_variant 1.0 pyrazinamide clpC1 4039412 c.1293T>G synonymous_variant 0.98 pyrazinamide clpC1 4039415 p.Glu430Asp missense_variant 1.0 pyrazinamide Uncertain significance clpC1 4039430 c.1275T>C synonymous_variant 1.0 pyrazinamide clpC1 4039439 c.1266C>T synonymous_variant 1.0 pyrazinamide clpC1 4039442 c.1263A>G synonymous_variant 1.0 pyrazinamide clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4039454 c.1251A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4039463 c.1242C>G synonymous_variant 1.0 pyrazinamide clpC1 4039466 c.1239T>C synonymous_variant 1.0 pyrazinamide clpC1 4039469 c.1236T>C synonymous_variant 1.0 pyrazinamide clpC1 4039472 c.1233G>C synonymous_variant 1.0 pyrazinamide clpC1 4039481 c.1224T>C synonymous_variant 1.0 pyrazinamide clpC1 4039484 c.1221T>C synonymous_variant 0.98 pyrazinamide clpC1 4039487 c.1218G>C synonymous_variant 0.98 pyrazinamide clpC1 4039517 c.1188C>G synonymous_variant 1.0 pyrazinamide clpC1 4039541 c.1164C>G synonymous_variant 0.98 pyrazinamide clpC1 4039553 c.1152C>A synonymous_variant 1.0 pyrazinamide clpC1 4039556 c.1149G>A synonymous_variant 0.98 pyrazinamide clpC1 4039559 c.1146C>G synonymous_variant 0.98 pyrazinamide clpC1 4039566 p.Val380Ala missense_variant 0.98 pyrazinamide clpC1 4039568 p.Met379Ile missense_variant 0.98 pyrazinamide Uncertain significance clpC1 4039575 p.Ala377Gly missense_variant 0.98 pyrazinamide clpC1 4039577 c.1128T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4039586 c.1119G>C synonymous_variant 1.0 pyrazinamide clpC1 4039592 c.1113G>C synonymous_variant 0.98 pyrazinamide clpC1 4039616 c.1089G>C synonymous_variant 0.98 pyrazinamide clpC1 4039622 c.1083C>T synonymous_variant 1.0 pyrazinamide clpC1 4039649 c.1056G>C synonymous_variant 0.96 pyrazinamide clpC1 4039661 c.1044T>C synonymous_variant 0.96 pyrazinamide clpC1 4039664 c.1041G>C synonymous_variant 0.96 pyrazinamide clpC1 4039670 c.1035G>C synonymous_variant 0.93 pyrazinamide clpC1 4039724 c.981A>G synonymous_variant 0.97 pyrazinamide clpC1 4039733 c.972G>C synonymous_variant 0.79 pyrazinamide clpC1 4039739 c.966C>G synonymous_variant 0.78 pyrazinamide clpC1 4039742 c.963C>T synonymous_variant 0.81 pyrazinamide clpC1 4039748 c.957G>C synonymous_variant 1.0 pyrazinamide clpC1 4039751 c.954A>G synonymous_variant 1.0 pyrazinamide clpC1 4039757 c.948A>G synonymous_variant 1.0 pyrazinamide clpC1 4039760 c.945T>C synonymous_variant 1.0 pyrazinamide clpC1 4039766 c.939T>C synonymous_variant 0.82 pyrazinamide clpC1 4039769 c.936C>G synonymous_variant 1.0 pyrazinamide clpC1 4039778 c.927A>G synonymous_variant 1.0 pyrazinamide clpC1 4039787 c.918G>C synonymous_variant 1.0 pyrazinamide clpC1 4039790 c.915C>G synonymous_variant 0.79 pyrazinamide clpC1 4039793 c.912C>G synonymous_variant 1.0 pyrazinamide clpC1 4039802 c.903G>C synonymous_variant 0.69 pyrazinamide clpC1 4039808 c.897G>A synonymous_variant 0.67 pyrazinamide clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.62 pyrazinamide clpC1 4039850 c.855T>C synonymous_variant 0.97 pyrazinamide clpC1 4039865 c.840T>C synonymous_variant 0.97 pyrazinamide clpC1 4039922 c.783C>T synonymous_variant 0.94 pyrazinamide clpC1 4039931 c.774T>C synonymous_variant 1.0 pyrazinamide clpC1 4039934 c.771G>A synonymous_variant 0.94 pyrazinamide clpC1 4039937 c.768G>C synonymous_variant 0.94 pyrazinamide clpC1 4039946 c.759A>T synonymous_variant 1.0 pyrazinamide clpC1 4039955 c.750G>C synonymous_variant 0.96 pyrazinamide clpC1 4039979 c.726C>G synonymous_variant 1.0 pyrazinamide clpC1 4039994 p.Glu237Asp missense_variant 0.99 pyrazinamide clpC1 4040009 c.696C>G synonymous_variant 0.99 pyrazinamide clpC1 4040015 c.690G>C synonymous_variant 0.98 pyrazinamide clpC1 4040021 c.684A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040024 c.681A>G synonymous_variant 1.0 pyrazinamide clpC1 4040087 c.618G>C synonymous_variant 0.96 pyrazinamide clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 1.0 pyrazinamide clpC1 4040093 c.612C>G synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim clpC1 4040144 c.561G>C synonymous_variant 0.91 pyrazinamide clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040153 c.552A>G synonymous_variant 1.0 pyrazinamide clpC1 4040162 c.543G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040165 c.540G>C synonymous_variant 1.0 pyrazinamide clpC1 4040168 c.537G>C synonymous_variant 0.95 pyrazinamide clpC1 4040171 c.534C>G synonymous_variant 1.0 pyrazinamide clpC1 4040180 c.525C>G synonymous_variant 0.93 pyrazinamide clpC1 4040200 c.505T>C synonymous_variant 0.89 pyrazinamide clpC1 4040201 c.504C>G synonymous_variant 0.94 pyrazinamide clpC1 4040204 c.501G>C synonymous_variant 0.88 pyrazinamide clpC1 4040207 c.498T>C synonymous_variant 0.94 pyrazinamide clpC1 4040214 p.Ser164Asn missense_variant 0.93 pyrazinamide clpC1 4040219 p.Ser162Ala missense_variant 0.88 pyrazinamide clpC1 4040225 c.480A>G synonymous_variant 0.94 pyrazinamide clpC1 4040228 c.477G>C synonymous_variant 0.94 pyrazinamide clpC1 4040243 c.462C>A synonymous_variant 0.9 pyrazinamide clpC1 4040249 c.456A>G synonymous_variant 0.95 pyrazinamide clpC1 4040255 p.Ala150Thr missense_variant 0.86 pyrazinamide clpC1 4040267 c.438A>G synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim clpC1 4040273 c.432T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.86 pyrazinamide clpC1 4040279 c.426C>G synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim clpC1 4040291 c.414G>C synonymous_variant 0.9 pyrazinamide clpC1 4040315 c.390G>A synonymous_variant 0.89 pyrazinamide clpC1 4040324 c.381G>C synonymous_variant 0.79 pyrazinamide clpC1 4040336 c.369G>C synonymous_variant 0.78 pyrazinamide clpC1 4040345 c.360C>G synonymous_variant 0.78 pyrazinamide clpC1 4040354 c.351A>G synonymous_variant 1.0 pyrazinamide clpC1 4040363 c.342A>C synonymous_variant 1.0 pyrazinamide clpC1 4040375 c.330G>C synonymous_variant 0.86 pyrazinamide clpC1 4040380 c.325T>C synonymous_variant 1.0 pyrazinamide clpC1 4040381 c.324T>C synonymous_variant 0.86 pyrazinamide clpC1 4040387 c.318A>G synonymous_variant 1.0 pyrazinamide clpC1 4040393 c.312G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040411 c.294T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040423 c.282A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040426 c.279T>C synonymous_variant 1.0 pyrazinamide clpC1 4040431 c.274T>C synonymous_variant 1.0 pyrazinamide clpC1 4040435 c.270G>C synonymous_variant 0.95 pyrazinamide clpC1 4040444 c.261C>G synonymous_variant 1.0 pyrazinamide clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040456 c.249C>A synonymous_variant 0.95 pyrazinamide clpC1 4040465 c.240T>C synonymous_variant 1.0 pyrazinamide clpC1 4040468 c.237G>C synonymous_variant 0.95 pyrazinamide clpC1 4040471 c.234T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040480 c.225T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040522 c.183T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040531 c.174T>C synonymous_variant 1.0 pyrazinamide clpC1 4040546 c.159G>C synonymous_variant 1.0 pyrazinamide clpC1 4040551 c.154T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040555 c.150G>A synonymous_variant 1.0 pyrazinamide clpC1 4040558 c.147G>C synonymous_variant 1.0 pyrazinamide clpC1 4040561 c.144A>G synonymous_variant 1.0 pyrazinamide clpC1 4040573 c.132T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim clpC1 4040579 c.126A>G synonymous_variant 1.0 pyrazinamide clpC1 4040582 c.123G>T synonymous_variant 0.95 pyrazinamide clpC1 4040585 c.120A>G synonymous_variant 1.0 pyrazinamide clpC1 4040588 c.117T>C synonymous_variant 1.0 pyrazinamide clpC1 4040596 c.109C>T synonymous_variant 1.0 pyrazinamide clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 1.0 pyrazinamide clpC1 4040603 c.102T>G synonymous_variant 1.0 pyrazinamide clpC1 4040606 c.99T>C synonymous_variant 1.0 pyrazinamide clpC1 4040644 c.61A>C synonymous_variant 1.0 pyrazinamide glpK 4138502 c.1254T>G synonymous_variant 0.9 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138511 c.1245C>T synonymous_variant 0.93 levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim isoniazid Not assoc w R - Interim streptomycin Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim glpK 4138514 c.1242A>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138523 c.1233C>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138529 c.1227G>C synonymous_variant 0.87 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138532 c.1224G>C synonymous_variant 0.87 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138535 c.1221T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138538 c.1218C>T synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138547 c.1209C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim isoniazid Not assoc w R - Interim streptomycin Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim glpK 4138556 c.1200G>C synonymous_variant 0.46 levofloxacin moxifloxacin isoniazid Not assoc w R - Interim streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim glpK 4138568 c.1188A>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138571 c.1185C>T synonymous_variant 0.4 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138574 c.1182G>A synonymous_variant 0.58 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138577 p.Leu393Val missense_variant 0.97 levofloxacin Uncertain significance moxifloxacin Uncertain significance isoniazid Uncertain significance streptomycin Uncertain significance rifampicin Uncertain significance ethambutol Uncertain significance glpK 4138583 c.1173G>C synonymous_variant 0.42 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138601 c.1155G>C synonymous_variant 0.97 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138604 c.1150_1152delTTGinsCTC synonymous_variant 0.59 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138613 c.1143C>T synonymous_variant 0.62 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138616 c.1140G>C synonymous_variant 0.66 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138619 c.1137C>A synonymous_variant 0.27 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138625 c.1131G>C synonymous_variant 0.95 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138628 c.1128T>C synonymous_variant 0.69 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138631 c.1125C>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138643 c.1113A>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid Not assoc w R - Interim streptomycin rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim glpK 4138646 c.1110G>C synonymous_variant 0.96 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138655 c.1101G>A synonymous_variant 0.94 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138661 c.1095T>C synonymous_variant 0.96 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138667 c.1089G>C synonymous_variant 0.95 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138676 c.1080T>C synonymous_variant 0.98 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138681 p.Met359Val missense_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138682 c.1074C>G synonymous_variant 0.93 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138694 p.Pro354Glu missense_variant 0.96 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138724 p.Ala344Ser missense_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138727 c.1029C>G synonymous_variant 0.98 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138730 c.1026C>T synonymous_variant 0.98 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138745 c.1011G>C synonymous_variant 0.98 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138751 c.1005T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138757 c.999A>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138775 c.981C>A synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138796 c.960A>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138817 c.939T>C synonymous_variant 0.95 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138822 p.Asn312Asp missense_variant 0.95 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138823 c.933G>C synonymous_variant 0.8 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138829 c.927A>G synonymous_variant 0.95 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138838 c.918G>C synonymous_variant 0.94 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138847 c.909A>G synonymous_variant 0.94 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138859 p.Asn299Gln missense_variant 0.92 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138875 p.Thr294Glu missense_variant 0.92 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138877 c.879A>G synonymous_variant 0.92 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4138898 c.858T>C synonymous_variant 0.91 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139150 c.606G>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139165 c.591A>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139168 c.588T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139177 c.579T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139183 c.573T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139186 c.570G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim moxifloxacin Not assoc w R - Interim isoniazid Not assoc w R - Interim streptomycin Not assoc w R - Interim rifampicin Not assoc w R - Interim ethambutol Not assoc w R - Interim glpK 4139189 c.567G>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139192 p.Pro188His missense_variant 0.91 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139215 c.541T>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139222 c.534C>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139228 p.Pro176Thr missense_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139231 c.525A>C synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139240 p.Leu172Ile missense_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol glpK 4139243 c.513A>G synonymous_variant 1.0 levofloxacin moxifloxacin isoniazid streptomycin rifampicin ethambutol embC 4240717 c.855T>C synonymous_variant 0.86 ethambutol embC 4240726 c.864G>C synonymous_variant 0.94 ethambutol Not assoc w R - Interim embC 4240736 p.Ser292Ala missense_variant 0.89 ethambutol embC 4240759 c.897C>G synonymous_variant 0.81 ethambutol embC 4240768 c.906G>C synonymous_variant 0.81 ethambutol embC 4240771 c.909G>C synonymous_variant 0.81 ethambutol embC 4240774 c.912C>G synonymous_variant 0.81 ethambutol embC 4240778 p.His306Asn missense_variant 0.81 ethambutol embC 4240783 c.921G>C synonymous_variant 0.95 ethambutol embC 4240789 c.927T>C synonymous_variant 0.95 ethambutol embC 4240807 c.945C>G synonymous_variant 0.94 ethambutol Not assoc w R - Interim embC 4240819 c.957A>C synonymous_variant 0.94 ethambutol embC 4240831 c.969T>G synonymous_variant 0.94 ethambutol embC 4240843 c.981C>T synonymous_variant 0.81 ethambutol embC 4241107 c.1245G>C synonymous_variant 1.0 ethambutol embC 4241109 p.Ala416Gly missense_variant 0.94 ethambutol embC 4241123 c.1261C>A synonymous_variant 0.94 ethambutol embC 4241137 c.1275G>A synonymous_variant 1.0 ethambutol embC 4241140 c.1278A>C synonymous_variant 1.0 ethambutol embC 4241141 p.Ile427Val missense_variant 1.0 ethambutol Uncertain significance embC 4241146 c.1284C>G synonymous_variant 0.93 ethambutol embC 4241147 p.Cys429Ile missense_variant 0.93 ethambutol embC 4241161 c.1299C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim embC 4241162 c.1300T>C synonymous_variant 1.0 ethambutol embC 4241179 c.1317G>A synonymous_variant 0.92 ethambutol embC 4241182 c.1320G>C synonymous_variant 1.0 ethambutol embC 4241185 c.1323G>C synonymous_variant 1.0 ethambutol embC 4241195 p.Ser445Ala missense_variant 1.0 ethambutol embC 4241198 p.Ile446Val missense_variant 1.0 ethambutol embC 4241203 c.1341T>C synonymous_variant 1.0 ethambutol embB 4247401 c.888T>C synonymous_variant 1.0 ethambutol embB 4247404 c.891G>C synonymous_variant 0.91 ethambutol embB 4247407 c.894G>C synonymous_variant 0.91 ethambutol embB 4247426 p.Gly305Gln missense_variant 0.77 ethambutol embB 4247434 c.921C>G synonymous_variant 0.77 ethambutol embB 4247437 c.924A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim embB 4247446 p.Asp311Glu missense_variant 0.77 ethambutol embB 4247464 c.951C>G synonymous_variant 0.93 ethambutol embB 4247470 c.957T>C synonymous_variant 1.0 ethambutol embB 4247491 c.978G>T synonymous_variant 1.0 ethambutol embB 4247500 c.987C>G synonymous_variant 1.0 ethambutol embB 4247512 c.999T>C synonymous_variant 1.0 ethambutol embB 4248277 c.1764G>C synonymous_variant 1.0 ethambutol embB 4248304 c.1791G>C synonymous_variant 1.0 ethambutol aftB 4269045 c.-209G>C upstream_gene_variant 0.9 ethambutol aftB 4269060 c.-224G>C upstream_gene_variant 0.92 ethambutol aftB 4269075 c.-239T>C upstream_gene_variant 1.0 ethambutol aftB 4269084 c.-248G>C upstream_gene_variant 0.92 ethambutol ubiA 4269088 p.Ala249Val missense_variant 1.0 ethambutol Uncertain significance ubiA 4269094 c.739_740insCGT conservative_inframe_insertion 1.0 ethambutol ubiA 4269098 p.Ser246Thr missense_variant 1.0 ethambutol aftB 4269099 c.-263G>C upstream_gene_variant 0.92 ethambutol ubiA 4269104 p.Ser244Gly missense_variant 1.0 ethambutol ubiA 4269106 p.Tyr243Thr missense_variant 1.0 ethambutol ubiA 4269109 p.Gly242Ala missense_variant 1.0 ethambutol aftB 4269114 c.-280_-278delCGCinsAGG upstream_gene_variant 0.92 ethambutol aftB 4269123 c.-287T>C upstream_gene_variant 1.0 ethambutol aftB 4269143 c.-307T>C upstream_gene_variant 1.0 ethambutol ubiA 4269144 c.690C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim ubiA 4269149 p.Val229Leu missense_variant 1.0 ethambutol Uncertain significance aftB 4269171 c.-335C>G upstream_gene_variant 0.94 ethambutol aftB 4269179 c.-343C>A upstream_gene_variant 1.0 ethambutol ubiA 4269186 p.Thr216Ser missense_variant 1.0 ethambutol Uncertain significance aftB 4269201 c.-365A>G upstream_gene_variant 1.0 ethambutol aftB 4269210 c.-374G>A upstream_gene_variant 1.0 ethambutol aftB 4269213 c.-377C>G upstream_gene_variant 1.0 ethambutol ubiA 4269220 p.Ala205Lys missense_variant 1.0 ethambutol ubiA 4269222 c.612T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim aftB 4269242 c.-406C>T upstream_gene_variant 1.0 ethambutol ubiA 4269243 p.His197Gln missense_variant 1.0 ethambutol aftB 4269246 c.-410G>C upstream_gene_variant 1.0 ethambutol aftB 4269249 c.-413G>A upstream_gene_variant 1.0 ethambutol aftB 4269258 c.-422C>G upstream_gene_variant 1.0 ethambutol aftB 4269264 c.-428C>A upstream_gene_variant 1.0 ethambutol ubiA 4269271 p.Val188Ala missense_variant 1.0 ethambutol Uncertain significance

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