TB-Profiler result

Run: ERR4799478
Summary

Run ID: ERR4799478

Sample name:

Date: 2024-04-15T21:21:50.984299

Number of reads: 1616001

Percentage reads mapped: 39.43

Median coverage: 39.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.95
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.91
lineage2.2 East-Asian (Beijing) RD105;RD207 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Asp311Gly Mutation from literature
p.Gln497Arg Assoc w R
pyrazinamide pncA p.Gly132Ala Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
gyrA p.Ala90Val Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin eis c.-10G>C Uncertain significance Mutation from literature
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
ethA c.571_573delGTGinsAC Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1120_1122delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1603_1605delTTGinsCA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2338_2340delCGCinsAA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2371_2373delCTTinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6738 p.Thr500Asn missense_variant 0.38 levofloxacin Uncertain significance Mutation from literature
moxifloxacin Uncertain significance Mutation from literature
gyrA 7570 p.Ala90Val missense_variant 0.39 levofloxacin Assoc w R
moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
rpoB 761155 p.Ser450Leu missense_variant 0.37 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.56 streptomycin Assoc w R
fbiC 1304050 c.1120_1122delTTGinsCC frameshift_variant&missense_variant 0.22 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304533 c.1603_1605delTTGinsCA frameshift_variant&missense_variant 0.61 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305268 c.2338_2340delCGCinsAA frameshift_variant&missense_variant 0.22 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305301 c.2371_2373delCTTinsTG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.23 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
inhA 1673425 c.-777C>T upstream_gene_variant 0.96 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG 2155168 p.Ser315Thr missense_variant 0.97 isoniazid Assoc w R High-level resistance
pncA 2288847 p.Gly132Ala missense_variant 0.97 pyrazinamide Assoc w R
eis 2715342 c.-10G>C upstream_gene_variant 0.92 kanamycin Uncertain significance Mutation from literature
embB 4247445 p.Asp311Gly missense_variant 0.19 ethambutol Mutation from literature
embB 4248003 p.Gln497Arg missense_variant 0.95 ethambutol Assoc w R
ethA 4326901 c.571_573delGTGinsAC frameshift_variant&missense_variant 0.33 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 600 c.600T>A synonymous_variant 0.21 isoniazid
dnaA 633 c.633T>C synonymous_variant 0.32 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 651 c.651G>C synonymous_variant 0.35 isoniazid
dnaA 663 c.663A>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.39 isoniazid
dnaA 682 c.682T>C synonymous_variant 0.39 isoniazid
dnaA 687 c.687C>T synonymous_variant 0.39 isoniazid
dnaA 690 c.690G>C synonymous_variant 0.39 isoniazid
dnaA 693 c.693A>C synonymous_variant 0.39 isoniazid
dnaA 699 c.699G>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.38 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.39 isoniazid
dnaA 714 c.714C>G synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 741 c.741T>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>C synonymous_variant 0.27 isoniazid
dnaA 750 c.750C>G synonymous_variant 0.2 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.51 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.47 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.47 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.49 isoniazid
dnaA 1122 c.1122C>T synonymous_variant 0.53 isoniazid
dnaA 1128 c.1128G>C synonymous_variant 0.47 isoniazid
dnaA 1134 c.1134G>C synonymous_variant 0.49 isoniazid
dnaA 1140 c.1140C>G synonymous_variant 0.51 isoniazid
dnaA 1149 c.1149C>G synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.48 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.48 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.46 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.46 isoniazid
dnaA 1165 c.1165_1167delCCAinsAG frameshift_variant&missense_variant 0.46 isoniazid Uncertain significance
dnaA 1177 p.Ala393Ser missense_variant 0.41 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.37 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.36 isoniazid
dnaA 1210 p.Ala404Ser missense_variant 0.29 isoniazid
gyrB 6086 c.847_849delACCinsCG frameshift_variant&missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin
gyrB 6091 c.852G>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6100 c.861G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6124 c.885C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6127 c.888G>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6196 c.957C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrB 6203 p.Ser322Ala missense_variant 0.53 levofloxacin
moxifloxacin
gyrB 6211 c.972G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.54 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6253 c.1014G>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>A synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6325 c.-977C>G upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Gly missense_variant 0.49 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6352 c.1113C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6358 c.1119C>G synonymous_variant 0.47 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6362 c.1123_1125delTTGinsCC frameshift_variant&missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin
gyrA 6367 c.-935C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6472 c.-830G>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6502 c.-800T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6508 c.-794A>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6511 c.-791A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6571 c.-731T>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6583 c.-719G>C upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 6592 c.-710C>T upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.66 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.66 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6766 c.-536G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.47 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6838 c.-464C>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6850 c.-452C>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 6896 p.Arg553Lys missense_variant 0.44 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 6926 c.1687T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6943 c.-359G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 6970 p.Asp577Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7021 c.-281G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Arg missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 7027 c.-275G>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 7047 p.Lys603Thr missense_variant 0.38 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.38 levofloxacin
moxifloxacin
gyrB 7057 c.1818C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7060 c.1821T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7114 c.-188C>G upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>G upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7198 c.1959C>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7201 c.-101G>A upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 7210 p.Asp657Glu missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7415 c.114C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7514 c.213C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7520 c.219G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7619 c.318C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 7758 p.Ile153Val missense_variant 0.4 levofloxacin Uncertain significance
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7796 c.495G>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7853 c.552C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7886 c.585T>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7889 c.588G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7906 p.Phe202Tyr missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8160 c.859_861delATCinsGG frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8279 c.978G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8282 c.981G>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.46 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8354 c.1053G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8363 c.1062C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 p.Asp367Asn missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8432 c.1131C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8433 p.Thr378Arg missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8468 c.1167C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8471 c.1170T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8537 c.1236G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8547 p.Ile416Val missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>A synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8588 p.Glu429Asp missense_variant 0.69 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8738 c.1437G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Lys missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8761 p.Val487Ala missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8767 p.Arg489Lys missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8769 p.His490Tyr missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.45 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8817 p.Ser506Ala missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8924 c.1623C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8984 c.1683C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9332 p.Asn677Lys missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCC frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9377 c.2076A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 491290 p.Val170Met missense_variant 0.97 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 0.95 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.21 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575705 c.358_360delTTGinsCC frameshift_variant&missense_variant 0.23 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575713 c.366G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.22 ethionamide
isoniazid Uncertain significance
mshA 575756 c.409C>T synonymous_variant 0.22 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.21 ethionamide
isoniazid
mshA 575785 c.438T>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575788 c.441C>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.22 ethionamide
isoniazid Not assoc w R - Interim
mshA 575818 c.471G>T synonymous_variant 0.19 ethionamide
isoniazid
mshA 575824 c.477T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575837 c.490C>T synonymous_variant 0.3 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575842 c.495G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575851 c.504C>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.43 ethionamide
isoniazid
mshA 575890 c.543C>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.65 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575911 c.564G>A synonymous_variant 0.3 ethionamide
isoniazid Not assoc w R - Interim
mshA 575914 c.567C>A synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575916 p.Asp190Ala missense_variant 0.31 ethionamide
isoniazid
mshA 575920 c.573C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575923 c.576C>T synonymous_variant 0.29 ethionamide
isoniazid
mshA 575925 p.Gly193Val missense_variant 0.29 ethionamide
isoniazid
mshA 575935 c.588G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575945 p.Thr200Ala missense_variant 0.31 ethionamide
isoniazid
mshA 575953 c.606G>T synonymous_variant 0.35 ethionamide
isoniazid
mshA 575977 c.630G>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.26 ethionamide
isoniazid
ccsA 620367 c.477T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.27 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620418 c.528G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620436 c.546T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620454 c.564C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620592 c.702C>T synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 0.97 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620709 c.819G>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620736 c.846G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620754 c.864G>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620758 p.Arg290Lys missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.33 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620783 p.Ala298Val missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>T synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620793 c.903G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620802 c.912C>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
hadA 731774 c.-156T>C upstream_gene_variant 0.2 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.23 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.34 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.36 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.52 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.61 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.6 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.58 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.62 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.61 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.59 rifampicin
nusG 734514 c.261A>G synonymous_variant 0.59 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
nusG 734544 c.291C>T synonymous_variant 0.49 rifampicin
nusG 734566 c.313C>T synonymous_variant 0.41 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.39 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760088 c.282C>G synonymous_variant 0.21 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.45 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.45 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.42 rifampicin Uncertain significance
rpoB 760133 c.327C>G synonymous_variant 0.4 rifampicin
rpoB 760139 c.333A>C synonymous_variant 0.42 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.41 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.4 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.37 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.35 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.38 rifampicin
rpoB 760317 c.511_513delAGCinsTCG synonymous_variant 0.38 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.42 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.41 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.51 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.53 rifampicin Uncertain significance
rpoB 760403 c.597C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.43 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.42 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760454 c.648C>G synonymous_variant 0.57 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.59 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.52 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.5 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.52 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.53 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.51 rifampicin
rpoB 760679 c.873A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760883 c.1077G>C synonymous_variant 0.63 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.57 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.57 rifampicin Uncertain significance
rpoB 760892 c.1086C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.69 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.71 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.74 rifampicin Uncertain significance
rpoB 760973 c.1167G>C synonymous_variant 0.81 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>T synonymous_variant 0.82 rifampicin
rpoB 760988 c.1182C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.83 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.74 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.71 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.57 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761531 c.1725C>G synonymous_variant 0.33 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.51 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.57 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.59 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.63 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761661 c.1855C>T synonymous_variant 0.61 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.63 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.6 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.65 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.61 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.58 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.58 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.49 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.48 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.52 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.55 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.52 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.52 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.54 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.53 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.63 rifampicin
rpoB 761819 c.2013G>C synonymous_variant 0.61 rifampicin
rpoB 761822 c.2016C>G synonymous_variant 0.61 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.6 rifampicin
rpoB 761837 c.2031C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.5 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.49 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.46 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>G synonymous_variant 0.43 rifampicin
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.45 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.41 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.44 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.45 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761955 p.Ile717Val missense_variant 0.4 rifampicin Uncertain significance
rpoB 761999 c.2193G>C synonymous_variant 0.58 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.68 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.7 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.69 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.69 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.68 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.74 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.71 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.69 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.73 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.71 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.68 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.58 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.57 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.51 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.51 rifampicin
rpoB 762359 c.2553C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.46 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.47 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.46 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.33 rifampicin
rpoC 762390 c.-980C>T upstream_gene_variant 0.32 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.34 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.36 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.34 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.46 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.56 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762800 c.-570C>G upstream_gene_variant 0.19 rifampicin
rpoB 762812 c.3006C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762827 c.-543G>T upstream_gene_variant 0.39 rifampicin
rpoB 762833 c.3027C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.44 rifampicin
rpoC 762851 c.-519C>T upstream_gene_variant 0.47 rifampicin
rpoC 762854 c.-516G>C upstream_gene_variant 0.5 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.54 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.4 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>G upstream_gene_variant 0.51 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.48 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763217 c.-153G>C upstream_gene_variant 0.48 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.44 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.44 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.42 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.42 rifampicin
rpoC 763259 c.-111G>C upstream_gene_variant 0.36 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763375 c.6C>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763396 c.27A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.3 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.32 rifampicin
rpoC 763420 c.51G>C synonymous_variant 0.31 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.3 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.31 rifampicin
rpoC 763435 c.66A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.57 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.54 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.57 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.51 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.51 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.47 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.46 rifampicin
rpoC 763781 c.412_414delTCGinsGC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.37 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.31 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.38 rifampicin
rpoC 763940 p.Ala191Ser missense_variant 0.4 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.4 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.39 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.4 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.43 rifampicin
rpoC 763999 c.630C>T synonymous_variant 0.42 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.45 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764017 c.648G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.42 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.45 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.42 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.41 rifampicin
rpoC 764048 p.Thr227Ser missense_variant 0.45 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.35 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.23 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.24 rifampicin
rpoC 764095 c.726C>G synonymous_variant 0.23 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Gln missense_variant 0.23 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.4 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.41 rifampicin Uncertain significance
rpoC 764153 p.Gln262Lys missense_variant 0.44 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.49 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.52 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Glu missense_variant 0.53 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.54 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.55 rifampicin
rpoC 764215 c.846A>G synonymous_variant 0.6 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.7 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.72 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.71 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>T synonymous_variant 0.7 rifampicin
rpoC 764285 p.Gly306Ser missense_variant 0.7 rifampicin
rpoC 764314 c.945C>T synonymous_variant 0.69 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.68 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.68 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.66 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.64 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.6 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764449 c.1080G>C synonymous_variant 0.56 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.58 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.65 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.69 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.68 rifampicin
rpoC 764506 c.1137C>T synonymous_variant 0.7 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.71 rifampicin
rpoC 764585 c.1216_1218delCTCinsTG frameshift_variant&missense_variant 0.7 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.73 rifampicin
rpoC 764755 c.1386C>T synonymous_variant 0.7 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.68 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.67 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.66 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764840 p.Ile491Val missense_variant 0.35 rifampicin Uncertain significance
rpoC 764858 c.1489T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.59 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.59 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.58 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.58 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.56 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.56 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.62 rifampicin
rpoC 764956 c.1587T>C synonymous_variant 0.6 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>T synonymous_variant 0.5 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 0.5 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.48 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.48 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>T synonymous_variant 0.52 rifampicin
rpoC 765076 c.1707A>G synonymous_variant 0.41 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.43 rifampicin
rpoC 765383 c.2014_2016delATGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 765397 c.2028G>T synonymous_variant 0.29 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.29 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765425 p.Lys686Glu missense_variant 0.31 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.29 rifampicin
rpoC 765452 p.Ala695Arg missense_variant 0.3 rifampicin
rpoC 765458 p.Ile697Val missense_variant 0.3 rifampicin Uncertain significance
rpoC 765466 c.2097C>T synonymous_variant 0.28 rifampicin
rpoC 765469 c.2100G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765712 c.2343C>G synonymous_variant 0.22 rifampicin
rpoC 765718 p.Asp783Glu missense_variant 0.28 rifampicin Uncertain significance
rpoC 765727 c.2358T>C synonymous_variant 0.37 rifampicin
rpoC 765728 p.Gln787Glu missense_variant 0.37 rifampicin
rpoC 765733 c.2364G>C synonymous_variant 0.38 rifampicin
rpoC 765741 p.Glu791Ala missense_variant 0.43 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.44 rifampicin
rpoC 765752 c.2383_2385delGACinsAG frameshift_variant&missense_variant 0.44 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.54 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.5 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.52 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.52 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.52 rifampicin
rpoC 765805 c.2436C>G synonymous_variant 0.53 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765812 c.2443_2445delCGAinsAG frameshift_variant&synonymous_variant 0.48 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>G synonymous_variant 0.46 rifampicin
rpoC 765871 c.2502T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.54 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.54 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765898 c.2529C>G synonymous_variant 0.56 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.61 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>T synonymous_variant 0.6 rifampicin
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.61 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.61 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.49 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.51 rifampicin
rpoC 766034 p.His889Thr missense_variant 0.51 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.41 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.34 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.38 rifampicin
rpoC 766324 c.2955C>G synonymous_variant 0.41 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.45 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.47 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766351 c.2982C>G synonymous_variant 0.46 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.49 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.51 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.57 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.61 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.65 rifampicin
rpoC 766423 c.3054T>C synonymous_variant 0.69 rifampicin
rpoC 766456 c.3087C>A synonymous_variant 0.73 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.76 rifampicin
rpoC 766468 c.3099G>A synonymous_variant 0.77 rifampicin
rpoC 766483 c.3114G>T synonymous_variant 0.74 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.74 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.72 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.73 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.67 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.66 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.64 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.62 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.59 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.58 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.45 rifampicin
rpoC 766613 p.Lys1082Arg missense_variant 0.38 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.34 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.33 rifampicin
rpoC 766628 p.Arg1087Lys missense_variant 0.32 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 0.34 rifampicin Not assoc w R
rpoC 766651 c.3282T>C synonymous_variant 0.31 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.3 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.3 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.29 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.35 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766712 c.3343_3345delTCGinsGT frameshift_variant&missense_variant 0.34 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.38 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.46 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.47 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.57 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.6 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.6 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.54 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.55 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.55 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.56 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.56 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.58 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766920 p.Ala1184Gly missense_variant 0.57 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.59 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>C synonymous_variant 0.66 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>T synonymous_variant 0.74 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.73 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.59 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.2 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775826 c.2655G>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775829 c.2652C>G synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 775838 c.2643G>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775847 c.2634G>T synonymous_variant 0.27 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775850 c.2631C>T synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775862 c.2619G>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 775874 c.2607C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775885 p.Ile866Val missense_variant 0.28 clofazimine
bedaquiline
mmpL5 775886 c.2595A>C synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775907 c.2574C>G synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 775910 c.2571G>T synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.44 clofazimine
bedaquiline
mmpL5 775954 c.2527C>T synonymous_variant 0.21 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775961 c.2518_2520delGTCinsAG frameshift_variant&missense_variant 0.2 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775970 c.2511G>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.37 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.31 clofazimine
bedaquiline
mmpL5 775990 c.2491C>T synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 776000 c.2481G>C synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 776021 c.2458_2460delGTGinsAC frameshift_variant&missense_variant 0.22 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776030 c.2451G>C synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 0.97 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpL5 777142 p.Val447Leu missense_variant 0.3 clofazimine
bedaquiline
mmpL5 777143 c.1338G>A synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 777161 p.Gln440Pro missense_variant 0.27 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 777173 c.1308C>A synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.27 clofazimine
bedaquiline
mmpL5 777188 c.1293T>C synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 777191 c.1290C>T synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 777212 c.1269C>G synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 777245 c.1236G>C synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 777254 c.1227G>C synonymous_variant 0.35 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 0.95 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781676 c.117C>G synonymous_variant 0.39 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.43 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.4 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.4 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.4 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.4 streptomycin
rpsL 781728 c.169_171delTTGinsCC frameshift_variant&missense_variant 0.39 streptomycin Uncertain significance
rpsL 781733 c.174G>C synonymous_variant 0.39 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.39 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.39 streptomycin
rpsL 781742 c.183C>A synonymous_variant 0.38 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.41 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.43 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.43 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.44 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.45 streptomycin
rpsL 781772 c.213C>G synonymous_variant 0.47 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.62 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.68 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.66 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.65 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.66 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.69 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.7 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.69 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.68 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.7 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.72 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.69 streptomycin Uncertain significance
rplC 800531 c.-278T>C upstream_gene_variant 0.29 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.29 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.31 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.32 linezolid
rplC 800564 c.-245C>G upstream_gene_variant 0.36 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.37 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.37 linezolid
rplC 800577 c.-232_-230delCGCinsAA upstream_gene_variant 0.38 linezolid
rplC 800585 c.-224T>C upstream_gene_variant 0.36 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.36 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.35 linezolid
rplC 800597 c.-212A>C upstream_gene_variant 0.35 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.34 linezolid
rplC 800603 c.-206G>T upstream_gene_variant 0.38 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.41 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.43 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.44 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.47 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.44 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.44 linezolid
rplC 800690 c.-119C>G upstream_gene_variant 0.45 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.44 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.42 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.41 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.4 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.41 linezolid
rplC 800729 c.-80G>C upstream_gene_variant 0.38 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.38 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.31 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.31 linezolid
rplC 800786 c.-23C>T upstream_gene_variant 0.16 linezolid
rplC 801252 c.444G>C synonymous_variant 0.27 linezolid
rplC 801264 c.456C>T synonymous_variant 0.22 linezolid
rplC 801267 c.459A>C synonymous_variant 0.22 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.22 linezolid
rplC 801285 c.477G>A synonymous_variant 0.22 linezolid
rplC 801300 c.492C>G synonymous_variant 0.22 linezolid
rplC 801303 c.495G>C synonymous_variant 0.23 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 0.22 linezolid
rplC 801312 c.504G>C synonymous_variant 0.23 linezolid
rplC 801324 c.516T>C synonymous_variant 0.23 linezolid
rplC 801330 c.522G>C synonymous_variant 0.22 linezolid
rplC 801348 c.540T>G synonymous_variant 0.21 linezolid
rplC 801349 p.Leu181Val missense_variant 0.2 linezolid
rplC 801354 c.546G>T synonymous_variant 0.2 linezolid
rplC 801357 c.549T>C synonymous_variant 0.18 linezolid
rplC 801385 c.577C>T synonymous_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303971 c.1041T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303977 c.1047C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304013 c.1083G>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304069 p.Val380Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304073 c.1143C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304079 p.Glu383Asp missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304082 c.1152C>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304106 c.1176G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304472 c.1542T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304475 c.1545G>C synonymous_variant 0.25 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304481 c.1551T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304484 c.1554C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304493 c.1563C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304503 p.Leu525Met missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304508 p.Glu526Asp missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304517 c.1587C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304538 c.1608C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304610 c.1680C>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>T synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>A synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304637 c.1707G>A synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304712 c.1782C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304718 c.1788C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.42 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304760 c.1830G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304775 c.1845C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305273 c.2343C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305277 p.His783Asn missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305348 c.2418C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305351 c.2421G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
sigE 1364790 c.378T>C synonymous_variant 0.25 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.3 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.34 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.38 pyrazinamide
sigE 1364823 c.411C>T synonymous_variant 0.41 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.43 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.43 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.45 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.48 pyrazinamide
sigE 1364860 c.448_450delCGCinsAG frameshift_variant&missense_variant 0.46 pyrazinamide Uncertain significance
sigE 1364865 c.453G>C synonymous_variant 0.46 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.46 pyrazinamide
sigE 1364877 c.465G>T synonymous_variant 0.55 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.59 pyrazinamide Uncertain significance
sigE 1364913 c.501C>G synonymous_variant 0.65 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.65 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.65 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.68 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.61 pyrazinamide Uncertain significance
sigE 1364961 c.549A>T synonymous_variant 0.57 pyrazinamide
sigE 1364964 c.552T>G synonymous_variant 0.57 pyrazinamide
sigE 1364976 c.564T>G synonymous_variant 0.58 pyrazinamide
sigE 1364979 c.567C>G synonymous_variant 0.57 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.57 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.56 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.61 pyrazinamide
sigE 1365015 c.603G>C synonymous_variant 0.59 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.53 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461071 c.27C>G synonymous_variant 0.32 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.5 bedaquiline
atpE 1461107 c.63C>A synonymous_variant 0.5 bedaquiline
atpE 1461131 c.87T>C synonymous_variant 0.49 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.47 bedaquiline
atpE 1461137 c.93C>G synonymous_variant 0.52 bedaquiline
atpE 1461146 c.102G>C synonymous_variant 0.5 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.5 bedaquiline
atpE 1461153 p.Ser37Ala missense_variant 0.5 bedaquiline Uncertain significance
atpE 1461158 c.114T>C synonymous_variant 0.48 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.48 bedaquiline Uncertain significance
atpE 1461164 c.120C>T synonymous_variant 0.52 bedaquiline
atpE 1461167 c.123G>C synonymous_variant 0.52 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.55 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.53 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.53 bedaquiline
atpE 1461188 c.144G>A synonymous_variant 0.52 bedaquiline
atpE 1461191 c.147G>C synonymous_variant 0.52 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.52 bedaquiline
atpE 1461212 c.168C>A synonymous_variant 0.48 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.43 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.36 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.32 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>T non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472325 n.480G>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473813 n.156C>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630_649delTCCTTTTCCTCTCCGGAGGAinsCTCGTTT non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1474710 n.1053delTinsGCAA non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475366 n.1709G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475382 n.1725A>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475396 n.1739C>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475616 n.1959A>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475618 n.1961C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475624 n.1967_1972delGGTGGGinsTGGGGGC non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475635 n.1978G>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>C non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.8 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476691 n.3034T>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476692 n.3035T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
inhA 1673667 c.-535A>G upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673673 c.-529C>T upstream_gene_variant 0.45 ethionamide
isoniazid
inhA 1673709 c.-493C>T upstream_gene_variant 0.53 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.53 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.55 ethionamide
isoniazid
fabG1 1673728 c.289_291delCTCinsTG frameshift_variant&missense_variant 0.49 ethionamide
isoniazid
fabG1 1673748 p.Glu103Asp missense_variant 0.47 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.47 ethionamide
isoniazid
inhA 1673757 c.-445G>A upstream_gene_variant 0.46 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.46 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673799 c.-403T>C upstream_gene_variant 0.45 ethionamide
isoniazid
inhA 1673805 c.-397G>C upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673808 c.-394A>C upstream_gene_variant 0.43 ethionamide
isoniazid
inhA 1673811 c.-391G>A upstream_gene_variant 0.41 ethionamide
isoniazid
fabG1 1673831 p.Lys131Arg missense_variant 0.18 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674474 c.273G>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674491 p.Phe97Tyr missense_variant 0.36 ethionamide
isoniazid
inhA 1674502 p.Thr101Ser missense_variant 0.39 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674534 c.333G>A synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.56 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674550 c.349_351delTCCinsGG frameshift_variant&missense_variant 0.51 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.61 ethionamide
isoniazid
inhA 1674620 p.Pro140Arg missense_variant 0.54 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.54 ethionamide
isoniazid
inhA 1674645 c.444C>T synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.64 ethionamide
isoniazid
inhA 1674658 c.457C>A synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674663 c.462G>C synonymous_variant 0.64 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674741 c.540C>T synonymous_variant 0.49 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674742 p.Lys181Pro missense_variant 0.49 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.58 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674777 c.576C>G synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674786 c.585G>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674789 c.588G>A synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674816 c.615T>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674828 p.Glu209Asp missense_variant 0.35 ethionamide
isoniazid
inhA 1674831 p.Glu210Asp missense_variant 0.33 ethionamide
isoniazid
inhA 1674834 c.633C>A synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674839 p.Ala213Asp missense_variant 0.3 ethionamide
isoniazid
inhA 1674847 p.Gln216Lys missense_variant 0.29 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.26 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>C synonymous_variant 0.38 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.4 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.44 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.44 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.44 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.46 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.48 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.5 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.49 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.51 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.52 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.6 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.6 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.61 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.61 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.62 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.63 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.61 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.61 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.62 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.61 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.62 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.7 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.7 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.72 pyrazinamide
rpsA 1833907 c.366G>A synonymous_variant 0.71 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.72 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.58 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.57 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.54 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.52 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834090 c.549G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.36 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834112 c.571C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>A synonymous_variant 0.23 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834282 c.741C>T synonymous_variant 0.69 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.68 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.7 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.73 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.62 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.62 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.57 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.45 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.45 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.49 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.52 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.56 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834657 c.1116G>A synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
rpsA 1834667 p.Ala376Ser missense_variant 0.59 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.74 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.7 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.68 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.64 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.64 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.57 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.6 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.56 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834787 c.1246_1248delGCTinsTC frameshift_variant&missense_variant 0.55 pyrazinamide Uncertain significance
rpsA 1834792 c.1251G>C synonymous_variant 0.55 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.51 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.53 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.59 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.59 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.62 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.59 linezolid
tsnR 1853418 c.-188_-186delCTTinsTG upstream_gene_variant 0.5 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.44 linezolid
tsnR 1853444 c.-162C>G upstream_gene_variant 0.34 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064981 c.-253G>C upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064990 c.-262G>C upstream_gene_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
bacA 2065002 c.-274C>G upstream_gene_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.96 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.63 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.56 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.48 isoniazid
kasA 2517993 c.-122G>A upstream_gene_variant 0.47 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.19 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.18 isoniazid
kasA 2518180 c.66G>C synonymous_variant 0.19 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.19 isoniazid
kasA 2518193 p.Pro27Ala missense_variant 0.19 isoniazid
kasA 2518219 c.105T>G synonymous_variant 0.2 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.2 isoniazid
kasA 2518444 c.330T>G synonymous_variant 0.21 isoniazid
kasA 2518447 c.333T>C synonymous_variant 0.2 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.23 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.34 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.34 isoniazid
kasA 2518513 c.399C>G synonymous_variant 0.34 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.34 isoniazid
kasA 2518525 c.411G>C synonymous_variant 0.33 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.32 isoniazid
kasA 2518531 c.417G>A synonymous_variant 0.32 isoniazid
kasA 2518534 c.420G>T synonymous_variant 0.32 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.38 isoniazid
kasA 2518555 c.441C>G synonymous_variant 0.47 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.45 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.45 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.4 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.4 isoniazid
kasA 2518595 c.481_483delCGCinsAG frameshift_variant&missense_variant 0.4 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.42 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.42 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.46 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.43 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.45 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.43 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.47 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.44 isoniazid
kasA 2518651 c.537C>A synonymous_variant 0.42 isoniazid
kasA 2518656 p.Ala181Gly missense_variant 0.41 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.43 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.41 isoniazid
kasA 2518688 p.Val192Ile missense_variant 0.4 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.41 isoniazid
kasA 2518697 p.Cys195Val missense_variant 0.37 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.33 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.31 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.32 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.37 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.45 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.45 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.36 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.37 isoniazid
kasA 2518769 p.Arg219Asn missense_variant 0.35 isoniazid
kasA 2518777 p.Asp221Glu missense_variant 0.32 isoniazid
kasA 2518778 c.664_666delGAGinsAC frameshift_variant&missense_variant 0.31 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.3 isoniazid
kasA 2518787 c.673_675delCGGinsGT frameshift_variant&missense_variant 0.29 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.29 isoniazid
kasA 2518811 p.Asp233Asn missense_variant 0.36 isoniazid
kasA 2518822 c.708C>A synonymous_variant 0.36 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.36 isoniazid
kasA 2518828 c.714G>C synonymous_variant 0.38 isoniazid
kasA 2518849 c.735G>C synonymous_variant 0.39 isoniazid
kasA 2518853 p.Leu247Val missense_variant 0.4 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.35 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.28 isoniazid
kasA 2519030 c.916_918delGACinsCG frameshift_variant&missense_variant 0.2 isoniazid
kasA 2519044 c.930G>C synonymous_variant 0.25 isoniazid
kasA 2519049 p.Gly312Ala missense_variant 0.22 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.23 isoniazid
kasA 2519060 c.946_948delCCTinsTG frameshift_variant&missense_variant 0.23 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.22 isoniazid
kasA 2519071 c.957C>T synonymous_variant 0.23 isoniazid
kasA 2519073 p.Ala320Val missense_variant 0.23 isoniazid
kasA 2519077 c.963G>C synonymous_variant 0.26 isoniazid
kasA 2519092 c.978C>T synonymous_variant 0.29 isoniazid
kasA 2519098 c.984C>G synonymous_variant 0.29 isoniazid
kasA 2519105 p.Cys331Val missense_variant 0.29 isoniazid
kasA 2519110 p.Asp332Glu missense_variant 0.29 isoniazid
kasA 2519113 p.Gln333His missense_variant 0.3 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.34 isoniazid
kasA 2519143 c.1029G>C synonymous_variant 0.34 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.34 isoniazid
kasA 2519158 c.1044C>A synonymous_variant 0.34 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.3 isoniazid
ahpC 2726597 c.405C>G synonymous_variant 0.23 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.22 isoniazid
ahpC 2726621 c.429G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726638 p.Ala149Val missense_variant 0.2 isoniazid
ahpC 2726642 c.450C>G synonymous_variant 0.22 isoniazid
ahpC 2726648 c.456T>G synonymous_variant 0.22 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.22 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.2 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.19 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.21 isoniazid
ahpC 2726693 c.501C>T synonymous_variant 0.22 isoniazid
ahpC 2726694 c.502_504delCTCinsTG frameshift_variant&missense_variant 0.23 isoniazid Uncertain significance
ahpC 2726708 c.516G>A synonymous_variant 0.2 isoniazid
Rv2477c 2782393 c.1650C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782398 c.1645A>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782399 c.1644T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782405 c.1638A>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782408 c.1635T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782414 p.Asp543Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782420 c.1623T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782429 c.1614A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782432 c.1611G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782495 p.Asp516Glu missense_variant 0.35 ethambutol
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782501 c.1542T>C synonymous_variant 0.33 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782522 c.1521G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782546 c.1497C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783155 c.888C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783185 c.858G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783218 c.825C>A synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783233 c.808_810delTTGinsCC frameshift_variant&missense_variant 0.57 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783239 p.Glu268Asp missense_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783260 c.783G>A synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Val missense_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.58 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 p.Pro206Lys missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783431 p.Ser204Glu missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783437 c.606G>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.55 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 c.475_477delAACinsCT frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783572 c.471A>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 c.465G>A synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783634 p.Leu137Ile missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783872 c.171G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783877 p.Lys56Gln missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783878 c.165C>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783883 c.160T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783947 c.96C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067364 c.582C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067715 c.229_231delAGCinsTCG synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.51 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067760 c.186G>T synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.5 para-aminosalicylic_acid
thyX 3067769 p.Gly59Ala missense_variant 0.48 para-aminosalicylic_acid
thyX 3067788 p.Lys53Arg missense_variant 0.45 para-aminosalicylic_acid
thyX 3067790 c.156C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067796 c.150C>G synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067829 c.117C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067862 c.84C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067869 p.Thr26Asp missense_variant 0.19 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067877 c.69G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073888 p.Ser195Glu missense_variant 0.27 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073893 c.579C>A synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073941 c.531C>T synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073965 c.507C>T synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3073971 c.501C>T synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073992 c.478_480delAGCinsTCG synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073999 p.Arg158Lys missense_variant 0.32 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074339 p.Leu45Phe missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.94 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625069 c.-159T>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625090 c.1524C>T synonymous_variant 0.5 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625095 p.Glu507Lys missense_variant 0.52 bedaquiline
rifampicin
lpqB 3625117 c.-207T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625122 c.-212C>A upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625135 c.-225A>C upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625138 c.-228C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.47 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.43 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625168 c.-258G>T upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625183 c.-273G>T upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625186 c.-276T>G upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625204 c.-294G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625219 c.-309C>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625228 c.-318G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625240 c.-330T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625246 c.-336G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625251 c.-341C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625263 p.Tyr451His missense_variant 0.36 bedaquiline
rifampicin
mtrB 3625264 c.1350C>T synonymous_variant 0.38 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625267 c.1347T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625291 p.Glu441Asp missense_variant 0.34 bedaquiline
rifampicin
lpqB 3625315 c.-405G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625321 c.1293A>G synonymous_variant 0.28 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625594 c.-684T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625615 c.-705G>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ala missense_variant 0.42 bedaquiline
rifampicin
mtrB 3625633 c.981C>T synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625636 p.Ala326Asp missense_variant 0.42 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.42 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625660 c.-750C>G upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625663 c.-753G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
lpqB 3625669 c.-759G>T upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625678 c.-768C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3625699 c.915C>T synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.52 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3625765 p.Ser283His missense_variant 0.48 bedaquiline
rifampicin
mtrB 3625774 c.840G>A synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625798 c.-888G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625801 c.-891G>C upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.54 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625822 c.-912C>T upstream_gene_variant 0.52 bedaquiline
rifampicin
lpqB 3625840 c.-930A>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3625845 p.Ser257Thr missense_variant 0.44 bedaquiline
rifampicin
lpqB 3625846 c.-936G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625867 c.747A>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625891 c.-981G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 0.95 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626669 c.-56T>A upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626684 c.-71G>A upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626711 p.Thr213Gln missense_variant 0.37 bedaquiline
rifampicin
mtrB 3626714 c.-101G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626750 c.-137T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.47 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626906 p.Asn148Leu missense_variant 0.23 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626915 c.-302C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626924 c.-311G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.53 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrA 3626949 p.Ala134Gly missense_variant 0.57 bedaquiline
rifampicin
mtrB 3626959 c.-346C>T upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.62 bedaquiline
rifampicin Uncertain significance
mtrB 3626987 c.-374C>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3626996 c.-383G>C upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3626999 c.-386G>C upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627032 c.-419G>C upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 0.66 bedaquiline
rifampicin
mtrB 3627044 c.-431C>T upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3627077 c.-464G>C upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627092 c.-479C>G upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3627158 c.-545C>G upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627185 c.163_165delTTGinsCC frameshift_variant&missense_variant 0.46 bedaquiline
rifampicin
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.46 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3627200 c.-587C>T upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627263 c.-650C>T upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3627269 c.81G>A synonymous_variant 0.43 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3627296 c.-683T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627307 p.Ala15Pro missense_variant 0.27 bedaquiline
rifampicin
mtrA 3627311 c.39C>T synonymous_variant 0.23 bedaquiline Not assoc w R - Interim
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627320 c.-707C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627325 c.-712T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
fbiA 3640316 c.-227A>G upstream_gene_variant 0.95 clofazimine
pretomanid
delamanid
rpoA 3877530 c.978C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877539 c.969C>T synonymous_variant 0.19 rifampicin
rpoA 3877545 c.963G>C synonymous_variant 0.21 rifampicin
rpoA 3877554 c.954G>C synonymous_variant 0.19 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877566 p.Ser314Thr missense_variant 0.19 rifampicin
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.19 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.45 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.56 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.54 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.58 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.72 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.69 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877794 c.714G>T synonymous_variant 0.68 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.68 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.7 rifampicin
rpoA 3877866 c.642G>A synonymous_variant 0.74 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877884 c.624G>C synonymous_variant 0.75 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Ala missense_variant 0.72 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.73 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.75 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.74 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.71 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.69 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.67 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.67 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.65 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.65 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.7 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.7 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.67 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.67 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.66 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.65 rifampicin
rpoA 3878097 c.411G>A synonymous_variant 0.63 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.63 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.63 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.6 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.6 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.58 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.58 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.51 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.55 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878166 c.342C>A synonymous_variant 0.56 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>T synonymous_variant 0.58 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.57 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.55 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.56 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.51 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.51 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.51 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.49 rifampicin
rpoA 3878262 c.244_246delAGCinsGA frameshift_variant&missense_variant 0.49 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.45 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.43 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.4 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.37 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.4 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.4 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.37 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.32 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.27 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.26 rifampicin
rpoA 3878384 c.124C>T synonymous_variant 0.24 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.24 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.23 rifampicin
rpoA 3878406 c.102G>T synonymous_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878881 c.-374C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878886 c.-379G>A upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.33 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878899 c.-392C>T upstream_gene_variant 0.31 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.33 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.4 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.4 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.38 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.37 rifampicin
rpoA 3878986 c.-479G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878992 c.-485C>T upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878995 c.-488A>G upstream_gene_variant 0.38 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3879007 c.-500G>C upstream_gene_variant 0.28 rifampicin
rpoA 3879019 c.-512T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.21 rifampicin
rpoA 3879028 c.-522_-521delGCinsCG upstream_gene_variant 0.2 rifampicin
rpoA 3879031 c.-526_-524delCCCinsTG upstream_gene_variant 0.21 rifampicin
rpoA 3879035 c.-528A>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3879037 c.-530G>C upstream_gene_variant 0.27 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.39 rifampicin
ddn 3986622 c.-222C>T upstream_gene_variant 0.52 delamanid
pretomanid
ddn 3986646 c.-198_-196delCTCinsTG upstream_gene_variant 0.45 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.46 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.41 delamanid
pretomanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.44 delamanid
pretomanid
ddn 3986687 c.-157C>T upstream_gene_variant 0.4 delamanid
pretomanid
clpC1 4038308 c.2395_2397delGTGinsCC frameshift_variant&missense_variant 0.19 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038325 p.Val794Ile missense_variant 0.21 pyrazinamide
clpC1 4038335 c.2370C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038353 c.2352G>A synonymous_variant 0.21 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.24 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038449 c.2256C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.23 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.21 pyrazinamide
clpC1 4038463 p.Ala748Thr missense_variant 0.22 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.2 pyrazinamide
clpC1 4038479 c.2226C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.23 pyrazinamide
clpC1 4038490 p.Ala739Ser missense_variant 0.27 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.32 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038519 p.Arg729Lys missense_variant 0.32 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.31 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.24 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.19 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.2 pyrazinamide
clpC1 4038692 c.2013C>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038698 c.2007C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.44 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.45 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.48 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.49 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4038887 c.1818G>A synonymous_variant 0.56 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.56 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.56 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.56 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.56 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.58 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.6 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038950 c.1755C>T synonymous_variant 0.64 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.66 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.66 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038974 c.1731T>A synonymous_variant 0.64 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.66 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.65 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.7 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.66 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.65 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039154 c.1551G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.52 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.52 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.49 pyrazinamide
clpC1 4039208 c.1495_1497delCTCinsTG frameshift_variant&synonymous_variant 0.52 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>A synonymous_variant 0.53 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.51 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.49 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.47 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.45 pyrazinamide
clpC1 4039316 c.1389G>A synonymous_variant 0.42 pyrazinamide
clpC1 4039319 c.1386T>G synonymous_variant 0.42 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.42 pyrazinamide
clpC1 4039347 p.Arg453Lys missense_variant 0.45 pyrazinamide
clpC1 4039357 c.1348C>T synonymous_variant 0.49 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.48 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.52 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.52 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>C synonymous_variant 0.53 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.53 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039565 p.Val380Ala missense_variant 0.61 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.61 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.62 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.76 pyrazinamide
clpC1 4039646 p.Glu353Ala missense_variant 0.67 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.72 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039688 c.1017G>A synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4039724 c.981A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039763 c.942C>A synonymous_variant 0.45 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.41 pyrazinamide
clpC1 4039802 c.903G>A synonymous_variant 0.41 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.34 pyrazinamide
clpC1 4039823 c.882T>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.36 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039925 c.779_780delGCinsTCGAGG frameshift_variant&synonymous_variant 0.55 pyrazinamide
clpC1 4039927 c.774_777delTAGC frameshift_variant 0.56 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.61 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039991 c.714G>A synonymous_variant 0.65 pyrazinamide Not assoc w R
clpC1 4039994 p.Glu237Asp missense_variant 0.63 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.58 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.58 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.61 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.6 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.49 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.55 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.6 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.6 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.57 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.55 pyrazinamide
clpC1 4040189 c.516C>T synonymous_variant 0.46 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.41 pyrazinamide
clpC1 4040213 p.Ser164Asn missense_variant 0.41 pyrazinamide
clpC1 4040219 c.484_486delTCCinsGA frameshift_variant&stop_gained 0.39 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.38 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.43 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040312 c.393G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040321 c.384C>T synonymous_variant 0.41 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040336 c.369G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040342 c.363C>T synonymous_variant 0.46 pyrazinamide
clpC1 4040351 c.354C>T synonymous_variant 0.44 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.49 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.47 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040414 c.291G>A synonymous_variant 0.56 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.56 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.56 pyrazinamide
clpC1 4040438 c.267G>A synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4040441 c.264C>G synonymous_variant 0.55 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.56 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.54 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.54 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.54 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.54 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.52 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.52 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.36 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.31 pyrazinamide
clpC1 4040585 c.120A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040594 c.111G>T synonymous_variant 0.29 pyrazinamide
clpC1 4040597 c.108C>A synonymous_variant 0.3 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.3 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.21 pyrazinamide
panD 4044147 c.135C>G synonymous_variant 0.25 pyrazinamide
panD 4044150 c.132A>C synonymous_variant 0.27 pyrazinamide
panD 4044159 c.123C>T synonymous_variant 0.33 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.33 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.31 pyrazinamide
panD 4044192 c.90C>G synonymous_variant 0.3 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.3 pyrazinamide
glpK 4138547 c.1209C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138574 c.1182G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138596 p.Phe387Tyr missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>A synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138646 c.1110G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>A synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138661 c.1095T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138664 c.1092G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138681 p.Met359Val missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138711 c.1045C>T synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138718 c.1038T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139302 p.Leu152Val missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139312 c.444T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139318 c.438T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139321 c.435T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139324 c.432A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139327 c.429G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139339 c.417G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139356 p.Leu134Val missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139359 p.Asn133Asp missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139360 c.396A>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139363 c.393T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139366 c.390T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139372 c.384A>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139375 c.381T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139378 c.378G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139387 c.369G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139408 c.348T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139417 c.339A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139420 c.336T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139430 p.Tyr109Cys missense_variant 0.27 ethambutol Uncertain significance
moxifloxacin
streptomycin Uncertain significance
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139435 c.321C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240726 c.864G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4240736 p.Ser292Ala missense_variant 0.29 ethambutol
embC 4240780 p.His306Gln missense_variant 0.38 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.38 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.37 ethambutol
embC 4240795 c.933C>G synonymous_variant 0.33 ethambutol
embC 4240807 c.945C>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4240831 c.969T>G synonymous_variant 0.31 ethambutol
embC 4241022 p.Ala387Val missense_variant 0.97 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.94 ethambutol Not assoc w R
embB 4247386 c.873T>C synonymous_variant 0.21 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.21 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.26 ethambutol
embB 4247404 c.891G>C synonymous_variant 0.27 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.26 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.21 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.2 ethambutol
embB 4247458 c.945C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247491 c.978G>C synonymous_variant 0.2 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.19 ethambutol
embB 4247506 c.993C>G synonymous_variant 0.2 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.19 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.95 ethambutol Not assoc w R
ethR 4326847 c.-702G>C upstream_gene_variant 0.24 ethionamide
ethR 4326850 c.-699T>C upstream_gene_variant 0.28 ethionamide
ethR 4326853 c.-696G>A upstream_gene_variant 0.28 ethionamide
ethA 4326888 p.Asp196Asn missense_variant 0.35 ethionamide Uncertain significance
ethR 4326889 c.-660C>G upstream_gene_variant 0.32 ethionamide
ethR 4326904 c.-645G>C upstream_gene_variant 0.31 ethionamide
ethR 4326913 c.-636C>G upstream_gene_variant 0.29 ethionamide
ethR 4326916 c.-633C>G upstream_gene_variant 0.29 ethionamide
ethR 4326919 c.-630T>G upstream_gene_variant 0.29 ethionamide
ethR 4326934 c.-615C>G upstream_gene_variant 0.27 ethionamide
ethA 4326943 p.Asn177Lys missense_variant 0.28 ethionamide
ethA 4326949 p.Ala175Gly missense_variant 0.27 ethionamide
ethA 4326953 p.Asp174Ala missense_variant 0.28 ethionamide
ethR 4326970 c.-579G>C upstream_gene_variant 0.26 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 0.9 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 0.83 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.94 streptomycin Not assoc w R