TB-Profiler

TB-Profiler result

Run: ERR987722

This average coverage of the target regions is below the recommended 30x. Some mutations may not be detected due to low coverage.

Summary

Run ID: ERR987722

Sample name:

Date: 2024-05-22T16:26:19.912362

Number of reads: 1795916

Percentage reads mapped: 25.02

Median coverage: 24.0

Strain:

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage4.6.1.2	Euro-American	RD724	1.0
lineage3.1.2.2	East-African-Indian	RD750	0.21
La1.7.1	M.bovis	None	0.22

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin	rpoB	c.1327_1329delTTGinsCC	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
isoniazid	katG	p.Ile335Thr		Mutation from literature
isoniazid	katG	c.949_951delATCinsCG	Assoc w R	High-level resistance
p.Ser315Thr	Assoc w R	High-level resistance
c.493_495delATTinsCC	Assoc w R	High-level resistance
ethambutol	embB	p.Ala356Val	Uncertain significance	Mutation from literature
ethambutol	embB	p.Asn399Asp		Mutation from literature
pyrazinamide	pncA	p.Arg154Gly	Assoc w R
streptomycin	rrs	n.517C>T	Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin	tlyA	c.451_453delGTAinsAC	Assoc w R
capreomycin	tlyA	c.481_483delGCTinsTG	Assoc w R
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid	fgd1	c.166_168delTCCinsGG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
delamanid	fbiC	c.532_534delGCAinsTG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.550_552delCAAinsGG	fbiC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.952_954delGTTinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiB	c.1177_1179delCTGinsGA	Assoc w R - Interim	Confers DLM-PMD cross-resistance
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
fgd1	490948	c.166_168delTCCinsGG	frameshift_variant&missense_variant	0.74	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fgd1	490948	c.166_168delTCCinsGG	frameshift_variant&missense_variant	0.74	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rpoB	761133	c.1327_1329delTTGinsCC	frameshift_variant&missense_variant	0.74	rifampicin	Assoc w R - Interim	Expert rule: Non-silent variants in RRDR of rpoB
fbiC	1303462	c.532_534delGCAinsTG	frameshift_variant&stop_gained	0.38	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303462	c.532_534delGCAinsTG	frameshift_variant&stop_gained	0.38	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303480	c.550_552delCAAinsGG	frameshift_variant&missense_variant	0.56	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303480	c.550_552delCAAinsGG	frameshift_variant&missense_variant	0.56	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303882	c.952_954delGTTinsAC	frameshift_variant&missense_variant	0.32	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303882	c.952_954delGTTinsAC	frameshift_variant&missense_variant	0.32	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	0.43	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	0.43	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rrs	1472362	n.517C>T	non_coding_transcript_exon_variant	0.27	streptomycin	Assoc w R
tlyA	1918390	c.451_453delGTAinsAC	frameshift_variant&missense_variant	0.38	capreomycin	Assoc w R
tlyA	1918420	c.481_483delGCTinsTG	frameshift_variant&missense_variant	0.48	capreomycin	Assoc w R
katG	2155107	p.Ile335Thr	missense_variant	0.54	isoniazid		Mutation from literature
katG	2155161	c.949_951delATCinsCG	frameshift_variant&missense_variant	0.46	isoniazid	Assoc w R	High-level resistance
katG	2155168	p.Ser315Thr	missense_variant	0.54	isoniazid	Assoc w R	High-level resistance
katG	2155617	c.493_495delATTinsCC	frameshift_variant&missense_variant	0.61	isoniazid	Assoc w R	High-level resistance
pncA	2288782	p.Arg154Gly	missense_variant	1.0	pyrazinamide	Assoc w R
fbiB	3642711	c.1177_1179delCTGinsGA	frameshift_variant&missense_variant	0.56	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiB	3642711	c.1177_1179delCTGinsGA	frameshift_variant&missense_variant	0.56	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
embB	4247580	p.Ala356Val	missense_variant	0.79	ethambutol	Uncertain significance	Mutation from literature
embB	4247708	p.Asn399Asp	missense_variant	0.58	ethambutol		Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	692	c.694delA	frameshift_variant	0.43	isoniazid	Uncertain significance
dnaA	705	c.705A>G	synonymous_variant	0.62	isoniazid
dnaA	708	c.708T>C	synonymous_variant	0.66	isoniazid
dnaA	714	c.714C>G	synonymous_variant	0.7	isoniazid	Not assoc w R - Interim
dnaA	717	c.717C>T	synonymous_variant	0.67	isoniazid
dnaA	741	c.741T>C	synonymous_variant	0.69	isoniazid	Not assoc w R - Interim
dnaA	750	c.750C>A	synonymous_variant	0.64	isoniazid
dnaA	756	c.756T>C	synonymous_variant	0.65	isoniazid
dnaA	771	c.771A>G	synonymous_variant	0.58	isoniazid
dnaA	777	c.777A>G	synonymous_variant	0.5	isoniazid
dnaA	849	c.849A>G	synonymous_variant	0.45	isoniazid
dnaA	852	c.852G>A	synonymous_variant	0.47	isoniazid	Not assoc w R - Interim
dnaA	876	c.876C>G	synonymous_variant	0.6	isoniazid
dnaA	885	c.885T>C	synonymous_variant	0.59	isoniazid
dnaA	891	c.891C>T	synonymous_variant	0.56	isoniazid	Not assoc w R - Interim
dnaA	897	c.897A>G	synonymous_variant	0.47	isoniazid
dnaA	903	c.903C>G	synonymous_variant	0.47	isoniazid	Not assoc w R - Interim
dnaA	909	c.909A>G	synonymous_variant	0.5	isoniazid
dnaA	912	c.912T>G	synonymous_variant	0.53	isoniazid
dnaA	918	c.918C>G	synonymous_variant	0.62	isoniazid
dnaA	921	c.921A>G	synonymous_variant	0.67	isoniazid	Not assoc w R - Interim
dnaA	984	c.984T>C	synonymous_variant	0.46	isoniazid	Not assoc w R - Interim
dnaA	990	c.990A>C	synonymous_variant	0.45	isoniazid
dnaA	996	c.996A>G	synonymous_variant	0.51	isoniazid
dnaA	1008	c.1008G>A	synonymous_variant	0.58	isoniazid	Not assoc w R - Interim
dnaA	1020	c.1020C>G	synonymous_variant	0.66	isoniazid
dnaA	1023	c.1023C>T	synonymous_variant	0.67	isoniazid
dnaA	1024	c.1024T>C	synonymous_variant	0.69	isoniazid
dnaA	1029	c.1029C>T	synonymous_variant	0.75	isoniazid
dnaA	1050	c.1050G>C	synonymous_variant	0.8	isoniazid
dnaA	1068	c.1068T>C	synonymous_variant	0.87	isoniazid
dnaA	1074	c.1074C>G	synonymous_variant	0.83	isoniazid
dnaA	1078	c.1078_1080delCTCinsTG	frameshift_variant&missense_variant	0.81	isoniazid	Uncertain significance
dnaA	1092	c.1092T>C	synonymous_variant	0.75	isoniazid	Not assoc w R - Interim
dnaA	1095	c.1095C>T	synonymous_variant	0.73	isoniazid	Not assoc w R - Interim
dnaA	1104	c.1104T>C	synonymous_variant	0.68	isoniazid
dnaA	1119	c.1119G>A	synonymous_variant	0.55	isoniazid
dnaA	1125	c.1125G>A	synonymous_variant	0.46	isoniazid	Not assoc w R - Interim
dnaA	1180	c.1180C>T	synonymous_variant	0.3	isoniazid	Not assoc w R - Interim
dnaA	1191	c.1191T>C	synonymous_variant	0.51	isoniazid
dnaA	1197	c.1197T>G	synonymous_variant	0.53	isoniazid
dnaA	1200	c.1200C>G	synonymous_variant	0.54	isoniazid
dnaA	1203	c.1203T>C	synonymous_variant	0.57	isoniazid
dnaA	1215	c.1215C>T	synonymous_variant	0.62	isoniazid
dnaA	1220	p.Asn407Ser	missense_variant	0.67	isoniazid
dnaA	1230	c.1230A>G	synonymous_variant	0.75	isoniazid
dnaA	1254	c.1254T>C	synonymous_variant	0.79	isoniazid
dnaA	1263	c.1263C>G	synonymous_variant	0.74	isoniazid
dnaA	1266	c.1266A>G	synonymous_variant	0.72	isoniazid
dnaA	1278	c.1278T>C	synonymous_variant	0.73	isoniazid
dnaA	1287	c.1287A>G	synonymous_variant	0.69	isoniazid
dnaA	1293	c.1293T>G	synonymous_variant	0.68	isoniazid
dnaA	1299	c.1299G>C	synonymous_variant	0.59	isoniazid	Not assoc w R - Interim
dnaA	1302	c.1302C>G	synonymous_variant	0.58	isoniazid
dnaA	1392	c.1392A>G	synonymous_variant	0.44	isoniazid
dnaA	1413	c.1413A>C	synonymous_variant	0.57	isoniazid
dnaA	1416	c.1416C>G	synonymous_variant	0.57	isoniazid
dnaA	1428	c.1428C>G	synonymous_variant	0.65	isoniazid
dnaA	1434	c.1434C>A	synonymous_variant	0.7	isoniazid
dnaA	1437	c.1437G>A	synonymous_variant	0.69	isoniazid
dnaA	1441	c.1441C>T	synonymous_variant	0.71	isoniazid
dnaA	1446	c.1446C>G	synonymous_variant	0.73	isoniazid	Not assoc w R - Interim
dnaA	1461	c.1461C>A	synonymous_variant	0.7	isoniazid
dnaA	1467	c.1467G>A	synonymous_variant	0.7	isoniazid	Not assoc w R - Interim
dnaA	1473	c.1473T>C	synonymous_variant	0.66	isoniazid	Not assoc w R - Interim
dnaA	1497	c.1497T>G	synonymous_variant	0.5	isoniazid
dnaA	1500	c.1500C>G	synonymous_variant	0.46	isoniazid
dnaA	1503	c.1503C>T	synonymous_variant	0.44	isoniazid
dnaA	1506	c.1506T>A	synonymous_variant	0.44	isoniazid
gyrB	5329	c.90C>T	synonymous_variant	0.39	levofloxacin
gyrB	5329	c.90C>T	synonymous_variant	0.39	moxifloxacin
gyrB	5338	c.99C>T	synonymous_variant	0.42	levofloxacin
gyrB	5338	c.99C>T	synonymous_variant	0.42	moxifloxacin
gyrB	5341	c.102T>C	synonymous_variant	0.41	levofloxacin
gyrB	5341	c.102T>C	synonymous_variant	0.41	moxifloxacin
gyrB	5344	c.105C>G	synonymous_variant	0.38	levofloxacin
gyrB	5344	c.105C>G	synonymous_variant	0.38	moxifloxacin
gyrB	5359	c.120C>G	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrB	5359	c.120C>G	synonymous_variant	0.5	moxifloxacin
gyrB	5362	c.123T>C	synonymous_variant	0.52	levofloxacin
gyrB	5362	c.123T>C	synonymous_variant	0.52	moxifloxacin
gyrB	5363	c.124_126delTTAinsCG	frameshift_variant&missense_variant	0.52	levofloxacin	Uncertain significance
gyrB	5363	c.124_126delTTAinsCG	frameshift_variant&missense_variant	0.52	moxifloxacin
gyrB	5371	c.132T>C	synonymous_variant	0.52	levofloxacin
gyrB	5371	c.132T>C	synonymous_variant	0.52	moxifloxacin
gyrB	5396	p.Ala53Ser	missense_variant	0.46	levofloxacin
gyrB	5396	p.Ala53Ser	missense_variant	0.46	moxifloxacin
gyrB	5803	c.564A>G	synonymous_variant	0.64	levofloxacin
gyrB	5803	c.564A>G	synonymous_variant	0.64	moxifloxacin
gyrB	5806	c.567C>G	synonymous_variant	0.64	levofloxacin
gyrB	5806	c.567C>G	synonymous_variant	0.64	moxifloxacin
gyrB	5809	c.570C>G	synonymous_variant	0.55	levofloxacin
gyrB	5809	c.570C>G	synonymous_variant	0.55	moxifloxacin
gyrB	5812	c.573C>G	synonymous_variant	0.53	levofloxacin
gyrB	5812	c.573C>G	synonymous_variant	0.53	moxifloxacin
gyrB	5819	c.580C>T	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrB	5819	c.580C>T	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrB	5824	c.585A>G	synonymous_variant	0.55	levofloxacin
gyrB	5824	c.585A>G	synonymous_variant	0.55	moxifloxacin
gyrB	5827	c.588G>A	synonymous_variant	0.55	levofloxacin
gyrB	5827	c.588G>A	synonymous_variant	0.55	moxifloxacin
gyrB	5848	c.609G>C	synonymous_variant	0.44	levofloxacin
gyrB	5848	c.609G>C	synonymous_variant	0.44	moxifloxacin
gyrB	6091	c.852G>C	synonymous_variant	0.56	levofloxacin
gyrB	6091	c.852G>C	synonymous_variant	0.56	moxifloxacin
gyrB	6106	c.867C>A	synonymous_variant	0.49	levofloxacin
gyrB	6106	c.867C>A	synonymous_variant	0.49	moxifloxacin
gyrB	6115	c.876A>G	synonymous_variant	0.73	levofloxacin
gyrB	6115	c.876A>G	synonymous_variant	0.73	moxifloxacin
gyrB	6122	p.Ala295Ser	missense_variant	0.45	levofloxacin
gyrB	6122	p.Ala295Ser	missense_variant	0.45	moxifloxacin
gyrB	6127	c.888G>T	synonymous_variant	0.7	levofloxacin
gyrB	6127	c.888G>T	synonymous_variant	0.7	moxifloxacin
gyrB	6172	c.933C>T	synonymous_variant	0.75	levofloxacin
gyrB	6172	c.933C>T	synonymous_variant	0.75	moxifloxacin
gyrB	6190	c.951A>G	synonymous_variant	0.73	levofloxacin
gyrB	6190	c.951A>G	synonymous_variant	0.73	moxifloxacin
gyrB	6214	c.975G>C	synonymous_variant	0.76	levofloxacin
gyrB	6214	c.975G>C	synonymous_variant	0.76	moxifloxacin
gyrB	6238	c.999G>A	synonymous_variant	0.71	levofloxacin	Not assoc w R - Interim
gyrB	6238	c.999G>A	synonymous_variant	0.71	moxifloxacin	Not assoc w R - Interim
gyrB	6242	p.Arg335Lys	missense_variant	0.71	levofloxacin
gyrB	6242	p.Arg335Lys	missense_variant	0.71	moxifloxacin
gyrB	6253	c.1014G>C	synonymous_variant	0.76	levofloxacin
gyrB	6253	c.1014G>C	synonymous_variant	0.76	moxifloxacin
gyrB	6265	c.1026C>T	synonymous_variant	0.75	levofloxacin	Not assoc w R - Interim
gyrB	6265	c.1026C>T	synonymous_variant	0.75	moxifloxacin	Not assoc w R - Interim
gyrB	6280	c.1041T>C	synonymous_variant	0.79	levofloxacin
gyrB	6280	c.1041T>C	synonymous_variant	0.79	moxifloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.74	levofloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.74	moxifloxacin
gyrB	6292	c.1053G>A	synonymous_variant	0.72	levofloxacin
gyrB	6292	c.1053G>A	synonymous_variant	0.72	moxifloxacin
gyrB	6298	c.1059C>G	synonymous_variant	0.66	levofloxacin
gyrB	6298	c.1059C>G	synonymous_variant	0.66	moxifloxacin
gyrB	6307	c.1068T>G	synonymous_variant	0.64	levofloxacin	Not assoc w R - Interim
gyrB	6307	c.1068T>G	synonymous_variant	0.64	moxifloxacin	Not assoc w R - Interim
gyrA	6316	c.-986G>C	upstream_gene_variant	0.68	levofloxacin
gyrA	6316	c.-986G>C	upstream_gene_variant	0.68	moxifloxacin
gyrB	6326	p.Ser363Ala	missense_variant	0.62	levofloxacin
gyrB	6326	p.Ser363Ala	missense_variant	0.62	moxifloxacin
gyrA	6331	c.-971A>G	upstream_gene_variant	0.64	levofloxacin
gyrA	6331	c.-971A>G	upstream_gene_variant	0.64	moxifloxacin
gyrA	6343	c.-959G>A	upstream_gene_variant	0.64	levofloxacin
gyrA	6343	c.-959G>A	upstream_gene_variant	0.64	moxifloxacin
gyrA	6652	c.-650C>T	upstream_gene_variant	0.28	levofloxacin
gyrA	6652	c.-650C>T	upstream_gene_variant	0.28	moxifloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	0.56	levofloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	0.56	moxifloxacin
gyrB	6674	c.1435_1437delCTTinsTG	frameshift_variant&missense_variant	0.5	levofloxacin	Uncertain significance
gyrB	6674	c.1435_1437delCTTinsTG	frameshift_variant&missense_variant	0.5	moxifloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.75	levofloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.75	moxifloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.77	levofloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.77	moxifloxacin
gyrA	6706	c.-596G>A	upstream_gene_variant	0.79	levofloxacin
gyrA	6706	c.-596G>A	upstream_gene_variant	0.79	moxifloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.82	levofloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.82	moxifloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.83	levofloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.83	moxifloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.86	levofloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.86	moxifloxacin
gyrA	6733	c.-569G>A	upstream_gene_variant	0.89	levofloxacin
gyrA	6733	c.-569G>A	upstream_gene_variant	0.89	moxifloxacin
gyrB	6745	c.1506T>C	synonymous_variant	0.84	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>C	synonymous_variant	0.84	moxifloxacin	Not assoc w R - Interim
gyrA	6751	c.-551G>C	upstream_gene_variant	0.88	levofloxacin
gyrA	6751	c.-551G>C	upstream_gene_variant	0.88	moxifloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.82	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.82	moxifloxacin
gyrB	6902	c.1663_1665delCTCinsTG	frameshift_variant&missense_variant	0.32	levofloxacin	Uncertain significance
gyrB	6902	c.1663_1665delCTCinsTG	frameshift_variant&missense_variant	0.32	moxifloxacin
gyrB	6911	p.Asn558His	missense_variant	0.46	levofloxacin
gyrB	6911	p.Asn558His	missense_variant	0.46	moxifloxacin
gyrB	6931	c.1692A>G	synonymous_variant	0.56	levofloxacin	Not assoc w R - Interim
gyrB	6931	c.1692A>G	synonymous_variant	0.56	moxifloxacin	Not assoc w R - Interim
gyrA	6934	c.-368A>G	upstream_gene_variant	0.56	levofloxacin
gyrA	6934	c.-368A>G	upstream_gene_variant	0.56	moxifloxacin
gyrA	6949	c.-353A>G	upstream_gene_variant	0.47	levofloxacin
gyrA	6949	c.-353A>G	upstream_gene_variant	0.47	moxifloxacin
gyrA	6955	c.-347G>A	upstream_gene_variant	0.45	levofloxacin
gyrA	6955	c.-347G>A	upstream_gene_variant	0.45	moxifloxacin
gyrA	7090	c.-212C>T	upstream_gene_variant	0.48	levofloxacin
gyrA	7090	c.-212C>T	upstream_gene_variant	0.48	moxifloxacin
gyrB	7093	c.1854T>C	synonymous_variant	0.53	levofloxacin	Not assoc w R - Interim
gyrB	7093	c.1854T>C	synonymous_variant	0.53	moxifloxacin	Not assoc w R - Interim
gyrA	7099	c.-203G>A	upstream_gene_variant	0.59	levofloxacin
gyrA	7099	c.-203G>A	upstream_gene_variant	0.59	moxifloxacin
gyrA	7129	c.-173T>G	upstream_gene_variant	0.71	levofloxacin
gyrA	7129	c.-173T>G	upstream_gene_variant	0.71	moxifloxacin
gyrA	7132	c.-170T>G	upstream_gene_variant	0.69	levofloxacin
gyrA	7132	c.-170T>G	upstream_gene_variant	0.69	moxifloxacin
gyrA	7136	c.-166T>C	upstream_gene_variant	0.71	levofloxacin
gyrA	7136	c.-166T>C	upstream_gene_variant	0.71	moxifloxacin
gyrA	7141	c.-161T>C	upstream_gene_variant	0.69	levofloxacin
gyrA	7141	c.-161T>C	upstream_gene_variant	0.69	moxifloxacin
gyrA	7147	c.-155G>C	upstream_gene_variant	0.72	levofloxacin
gyrA	7147	c.-155G>C	upstream_gene_variant	0.72	moxifloxacin
gyrA	7150	c.-152G>C	upstream_gene_variant	0.72	levofloxacin
gyrA	7150	c.-152G>C	upstream_gene_variant	0.72	moxifloxacin
gyrA	7153	c.-149G>T	upstream_gene_variant	0.71	levofloxacin
gyrA	7153	c.-149G>T	upstream_gene_variant	0.71	moxifloxacin
gyrB	7156	c.1917C>T	synonymous_variant	0.72	levofloxacin	Not assoc w R - Interim
gyrB	7156	c.1917C>T	synonymous_variant	0.72	moxifloxacin	Not assoc w R - Interim
gyrA	7174	c.-128C>T	upstream_gene_variant	0.77	levofloxacin
gyrA	7174	c.-128C>T	upstream_gene_variant	0.77	moxifloxacin
gyrA	7177	c.-125G>A	upstream_gene_variant	0.74	levofloxacin
gyrA	7177	c.-125G>A	upstream_gene_variant	0.74	moxifloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.74	levofloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.74	moxifloxacin
gyrA	7201	c.-101G>A	upstream_gene_variant	0.67	levofloxacin
gyrA	7201	c.-101G>A	upstream_gene_variant	0.67	moxifloxacin
gyrA	7213	c.-89G>C	upstream_gene_variant	0.59	levofloxacin
gyrA	7213	c.-89G>C	upstream_gene_variant	0.59	moxifloxacin
gyrA	7334	c.33G>C	synonymous_variant	0.33	levofloxacin
gyrA	7334	c.33G>C	synonymous_variant	0.33	moxifloxacin
gyrA	7335	p.Leu12Val	missense_variant	0.36	levofloxacin
gyrA	7335	p.Leu12Val	missense_variant	0.36	moxifloxacin
gyrA	7349	c.48A>G	synonymous_variant	0.66	levofloxacin
gyrA	7349	c.48A>G	synonymous_variant	0.66	moxifloxacin
gyrA	7361	c.60C>T	synonymous_variant	0.74	levofloxacin
gyrA	7361	c.60C>T	synonymous_variant	0.74	moxifloxacin
gyrA	7362	c.61_63delGAGinsCA	frameshift_variant&missense_variant	1.0	levofloxacin
gyrA	7362	c.61_63delGAGinsCA	frameshift_variant&missense_variant	1.0	moxifloxacin
gyrA	7391	c.90C>T	synonymous_variant	0.77	levofloxacin	Not assoc w R - Interim
gyrA	7391	c.90C>T	synonymous_variant	0.77	moxifloxacin	Not assoc w R - Interim
gyrA	7394	c.93T>C	synonymous_variant	0.79	levofloxacin	Not assoc w R - Interim
gyrA	7394	c.93T>C	synonymous_variant	0.79	moxifloxacin
gyrA	7412	c.111C>G	synonymous_variant	0.8	levofloxacin
gyrA	7412	c.111C>G	synonymous_variant	0.8	moxifloxacin
gyrA	7422	c.121C>T	synonymous_variant	0.69	levofloxacin
gyrA	7422	c.121C>T	synonymous_variant	0.69	moxifloxacin
gyrA	7433	c.132G>C	synonymous_variant	0.63	levofloxacin
gyrA	7433	c.132G>C	synonymous_variant	0.63	moxifloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.77	levofloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.77	moxifloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.75	levofloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.75	moxifloxacin
gyrA	7469	c.168C>G	synonymous_variant	0.78	levofloxacin	Not assoc w R - Interim
gyrA	7469	c.168C>G	synonymous_variant	0.78	moxifloxacin	Not assoc w R - Interim
gyrA	7472	c.171T>C	synonymous_variant	0.81	levofloxacin	Not assoc w R - Interim
gyrA	7472	c.171T>C	synonymous_variant	0.81	moxifloxacin
gyrA	7475	c.174A>G	synonymous_variant	0.77	levofloxacin	Not assoc w R - Interim
gyrA	7475	c.174A>G	synonymous_variant	0.77	moxifloxacin	Not assoc w R - Interim
gyrA	7480	p.Phe60Tyr	missense_variant	0.76	levofloxacin
gyrA	7480	p.Phe60Tyr	missense_variant	0.76	moxifloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.78	levofloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.78	moxifloxacin
gyrA	7490	c.189C>G	synonymous_variant	0.8	levofloxacin
gyrA	7490	c.189C>G	synonymous_variant	0.8	moxifloxacin
gyrA	7502	c.201C>T	synonymous_variant	0.81	levofloxacin
gyrA	7502	c.201C>T	synonymous_variant	0.81	moxifloxacin
gyrA	7526	c.225G>T	synonymous_variant	0.78	levofloxacin	Not assoc w R - Interim
gyrA	7526	c.225G>T	synonymous_variant	0.78	moxifloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.8	levofloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.8	moxifloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.79	levofloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.79	moxifloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.78	levofloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.78	moxifloxacin	Not assoc w R - Interim
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7601	c.300C>G	synonymous_variant	0.8	levofloxacin	Not assoc w R - Interim
gyrA	7601	c.300C>G	synonymous_variant	0.8	moxifloxacin	Not assoc w R - Interim
gyrA	7626	c.325C>T	synonymous_variant	0.79	levofloxacin
gyrA	7626	c.325C>T	synonymous_variant	0.79	moxifloxacin
gyrA	7631	c.330G>C	synonymous_variant	0.69	levofloxacin
gyrA	7631	c.330G>C	synonymous_variant	0.69	moxifloxacin
gyrA	7643	c.342C>T	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrA	7643	c.342C>T	synonymous_variant	0.54	moxifloxacin
gyrA	7676	c.375G>C	synonymous_variant	0.39	levofloxacin
gyrA	7676	c.375G>C	synonymous_variant	0.39	moxifloxacin
gyrA	7679	c.378G>C	synonymous_variant	0.47	levofloxacin
gyrA	7679	c.378G>C	synonymous_variant	0.47	moxifloxacin
gyrA	7697	c.396C>G	synonymous_variant	0.62	levofloxacin
gyrA	7697	c.396C>G	synonymous_variant	0.62	moxifloxacin
gyrA	7706	c.405C>G	synonymous_variant	0.75	levofloxacin
gyrA	7706	c.405C>G	synonymous_variant	0.75	moxifloxacin
gyrA	7725	c.424C>T	synonymous_variant	0.82	levofloxacin	Not assoc w R - Interim
gyrA	7725	c.424C>T	synonymous_variant	0.82	moxifloxacin
gyrA	7728	c.427_429delAGGinsCC	frameshift_variant&missense_variant	0.82	levofloxacin
gyrA	7728	c.427_429delAGGinsCC	frameshift_variant&missense_variant	0.82	moxifloxacin
gyrA	7763	c.462T>C	synonymous_variant	0.91	levofloxacin	Not assoc w R - Interim
gyrA	7763	c.462T>C	synonymous_variant	0.91	moxifloxacin	Not assoc w R - Interim
gyrA	7769	c.468C>T	synonymous_variant	0.91	levofloxacin
gyrA	7769	c.468C>T	synonymous_variant	0.91	moxifloxacin
gyrA	7787	c.486G>A	synonymous_variant	0.88	levofloxacin
gyrA	7787	c.486G>A	synonymous_variant	0.88	moxifloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.82	levofloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.82	moxifloxacin
gyrA	7797	c.496_498delCTAinsTG	frameshift_variant&stop_gained	0.82	levofloxacin
gyrA	7797	c.496_498delCTAinsTG	frameshift_variant&stop_gained	0.82	moxifloxacin
gyrA	7820	c.519G>C	synonymous_variant	0.84	levofloxacin
gyrA	7820	c.519G>C	synonymous_variant	0.84	moxifloxacin
gyrA	7832	c.531G>T	synonymous_variant	0.81	levofloxacin
gyrA	7832	c.531G>T	synonymous_variant	0.81	moxifloxacin
gyrA	7835	c.534A>G	synonymous_variant	0.81	levofloxacin	Not assoc w R - Interim
gyrA	7835	c.534A>G	synonymous_variant	0.81	moxifloxacin	Not assoc w R - Interim
gyrA	7859	c.558A>C	synonymous_variant	0.76	levofloxacin
gyrA	7859	c.558A>C	synonymous_variant	0.76	moxifloxacin
gyrA	7865	c.564T>C	synonymous_variant	0.73	levofloxacin
gyrA	7865	c.564T>C	synonymous_variant	0.73	moxifloxacin
gyrA	7868	c.567C>T	synonymous_variant	0.69	levofloxacin
gyrA	7868	c.567C>T	synonymous_variant	0.69	moxifloxacin
gyrA	7883	c.582G>C	synonymous_variant	0.47	levofloxacin
gyrA	7883	c.582G>C	synonymous_variant	0.47	moxifloxacin
gyrA	7884	c.583_585delCGTinsGC	frameshift_variant&missense_variant	0.47	levofloxacin
gyrA	7884	c.583_585delCGTinsGC	frameshift_variant&missense_variant	0.47	moxifloxacin
gyrA	7892	c.591G>C	synonymous_variant	0.39	levofloxacin
gyrA	7892	c.591G>C	synonymous_variant	0.39	moxifloxacin
gyrA	7898	p.Asp199Glu	missense_variant	0.37	levofloxacin
gyrA	7898	p.Asp199Glu	missense_variant	0.37	moxifloxacin
gyrA	7901	c.600G>T	synonymous_variant	0.35	levofloxacin
gyrA	7901	c.600G>T	synonymous_variant	0.35	moxifloxacin
gyrA	7904	c.603G>C	synonymous_variant	0.35	levofloxacin
gyrA	7904	c.603G>C	synonymous_variant	0.35	moxifloxacin
gyrA	8121	c.820_822delTTGinsCC	frameshift_variant&missense_variant	0.57	levofloxacin
gyrA	8121	c.820_822delTTGinsCC	frameshift_variant&missense_variant	0.57	moxifloxacin
gyrA	8126	c.825G>C	synonymous_variant	0.6	levofloxacin	Not assoc w R - Interim
gyrA	8126	c.825G>C	synonymous_variant	0.6	moxifloxacin	Not assoc w R - Interim
gyrA	8156	c.855T>C	synonymous_variant	0.75	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.75	moxifloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.74	levofloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.74	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.73	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.73	moxifloxacin
gyrA	8189	c.888G>C	synonymous_variant	0.67	levofloxacin	Not assoc w R - Interim
gyrA	8189	c.888G>C	synonymous_variant	0.67	moxifloxacin	Not assoc w R - Interim
gyrA	8192	c.891C>G	synonymous_variant	0.64	levofloxacin
gyrA	8192	c.891C>G	synonymous_variant	0.64	moxifloxacin
gyrA	8198	c.897T>C	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrA	8201	c.900C>G	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	8201	c.900C>G	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	8207	c.906T>C	synonymous_variant	0.54	levofloxacin
gyrA	8207	c.906T>C	synonymous_variant	0.54	moxifloxacin
gyrA	8253	p.Ile318Leu	missense_variant	0.63	levofloxacin
gyrA	8253	p.Ile318Leu	missense_variant	0.63	moxifloxacin
gyrA	8267	c.966G>C	synonymous_variant	0.7	levofloxacin	Not assoc w R - Interim
gyrA	8267	c.966G>C	synonymous_variant	0.7	moxifloxacin	Not assoc w R - Interim
gyrA	8270	c.969G>C	synonymous_variant	0.74	levofloxacin
gyrA	8270	c.969G>C	synonymous_variant	0.74	moxifloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.81	levofloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.81	moxifloxacin
gyrA	8288	c.987T>C	synonymous_variant	0.82	levofloxacin	Not assoc w R - Interim
gyrA	8288	c.987T>C	synonymous_variant	0.82	moxifloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.84	levofloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.84	moxifloxacin	Not assoc w R - Interim
gyrA	8324	c.1023T>C	synonymous_variant	0.8	levofloxacin
gyrA	8324	c.1023T>C	synonymous_variant	0.8	moxifloxacin
gyrA	8339	c.1038A>G	synonymous_variant	0.74	levofloxacin
gyrA	8339	c.1038A>G	synonymous_variant	0.74	moxifloxacin
gyrA	8340	p.Ala347Ser	missense_variant	0.74	levofloxacin	Uncertain significance
gyrA	8340	p.Ala347Ser	missense_variant	0.74	moxifloxacin	Uncertain significance
gyrA	8360	c.1059G>A	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
gyrA	8360	c.1059G>A	synonymous_variant	0.63	moxifloxacin	Not assoc w R - Interim
gyrA	8372	c.1071G>T	synonymous_variant	0.5	levofloxacin
gyrA	8372	c.1071G>T	synonymous_variant	0.5	moxifloxacin
gyrA	8375	c.1074G>C	synonymous_variant	0.49	levofloxacin	Not assoc w R - Interim
gyrA	8375	c.1074G>C	synonymous_variant	0.49	moxifloxacin
gyrA	8382	p.Leu361Met	missense_variant	0.44	levofloxacin
gyrA	8382	p.Leu361Met	missense_variant	0.44	moxifloxacin
gyrA	8504	c.1203G>C	synonymous_variant	0.56	levofloxacin
gyrA	8504	c.1203G>C	synonymous_variant	0.56	moxifloxacin
gyrA	8516	c.1215T>C	synonymous_variant	0.59	levofloxacin
gyrA	8516	c.1215T>C	synonymous_variant	0.59	moxifloxacin
gyrA	8519	c.1218A>G	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrA	8519	c.1218A>G	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrA	8520	c.1219C>T	synonymous_variant	0.58	levofloxacin
gyrA	8520	c.1219C>T	synonymous_variant	0.58	moxifloxacin
gyrA	8531	c.1230G>T	synonymous_variant	0.73	levofloxacin	Not assoc w R - Interim
gyrA	8531	c.1230G>T	synonymous_variant	0.73	moxifloxacin	Not assoc w R - Interim
gyrA	8535	p.Glu412Gln	missense_variant	0.74	levofloxacin
gyrA	8535	p.Glu412Gln	missense_variant	0.74	moxifloxacin
gyrA	8543	c.1242C>T	synonymous_variant	0.73	levofloxacin
gyrA	8543	c.1242C>T	synonymous_variant	0.73	moxifloxacin
gyrA	8546	c.1245T>C	synonymous_variant	0.75	levofloxacin	Not assoc w R - Interim
gyrA	8546	c.1245T>C	synonymous_variant	0.75	moxifloxacin	Not assoc w R - Interim
gyrA	8555	c.1254G>C	synonymous_variant	0.8	levofloxacin
gyrA	8555	c.1254G>C	synonymous_variant	0.8	moxifloxacin
gyrA	8561	c.1260A>G	synonymous_variant	0.82	levofloxacin
gyrA	8561	c.1260A>G	synonymous_variant	0.82	moxifloxacin
gyrA	8585	c.1284C>T	synonymous_variant	0.83	levofloxacin
gyrA	8585	c.1284C>T	synonymous_variant	0.83	moxifloxacin
gyrA	8588	c.1287G>A	synonymous_variant	0.83	levofloxacin
gyrA	8588	c.1287G>A	synonymous_variant	0.83	moxifloxacin
gyrA	8619	c.1318T>C	synonymous_variant	0.78	levofloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.78	moxifloxacin	Not assoc w R - Interim
gyrA	8624	c.1323G>T	synonymous_variant	0.8	levofloxacin	Not assoc w R - Interim
gyrA	8624	c.1323G>T	synonymous_variant	0.8	moxifloxacin	Not assoc w R - Interim
gyrA	8627	c.1326C>A	synonymous_variant	0.8	levofloxacin
gyrA	8627	c.1326C>A	synonymous_variant	0.8	moxifloxacin
gyrA	8636	c.1335A>C	synonymous_variant	0.8	levofloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>C	synonymous_variant	0.8	moxifloxacin	Not assoc w R - Interim
gyrA	8642	c.1341A>G	synonymous_variant	0.76	levofloxacin
gyrA	8642	c.1341A>G	synonymous_variant	0.76	moxifloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.68	levofloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.68	moxifloxacin
gyrA	8672	c.1371A>G	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
gyrA	8672	c.1371A>G	synonymous_variant	0.63	moxifloxacin	Not assoc w R - Interim
gyrA	8678	c.1377G>A	synonymous_variant	0.66	levofloxacin
gyrA	8678	c.1377G>A	synonymous_variant	0.66	moxifloxacin
gyrA	8694	c.1393C>T	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	8694	c.1393C>T	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	8765	p.Asp488Glu	missense_variant	0.36	levofloxacin	Uncertain significance
gyrA	8765	p.Asp488Glu	missense_variant	0.36	moxifloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.37	levofloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.37	moxifloxacin	Uncertain significance
gyrA	8779	p.Asp493Ala	missense_variant	0.3	levofloxacin
gyrA	8779	p.Asp493Ala	missense_variant	0.3	moxifloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.28	levofloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.28	moxifloxacin
gyrA	8789	c.1488C>T	synonymous_variant	0.28	levofloxacin
gyrA	8789	c.1488C>T	synonymous_variant	0.28	moxifloxacin
gyrA	8792	c.1491G>C	synonymous_variant	0.28	levofloxacin
gyrA	8792	c.1491G>C	synonymous_variant	0.28	moxifloxacin
gyrA	8798	c.1497C>T	synonymous_variant	0.33	levofloxacin	Not assoc w R - Interim
gyrA	8798	c.1497C>T	synonymous_variant	0.33	moxifloxacin	Not assoc w R - Interim
gyrA	8810	c.1509A>C	synonymous_variant	0.31	levofloxacin
gyrA	8810	c.1509A>C	synonymous_variant	0.31	moxifloxacin
gyrA	8813	p.Asp504Glu	missense_variant	0.31	levofloxacin	Uncertain significance
gyrA	8813	p.Asp504Glu	missense_variant	0.31	moxifloxacin	Uncertain significance
gyrA	8818	p.Ser506Asn	missense_variant	0.31	levofloxacin	Uncertain significance
gyrA	8818	p.Ser506Asn	missense_variant	0.31	moxifloxacin	Uncertain significance
gyrA	8897	c.1596T>C	synonymous_variant	0.51	levofloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.51	moxifloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	8924	c.1623C>T	synonymous_variant	0.61	levofloxacin
gyrA	8924	c.1623C>T	synonymous_variant	0.61	moxifloxacin
gyrA	8930	c.1629C>G	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	8930	c.1629C>G	synonymous_variant	0.57	moxifloxacin
gyrA	8933	c.1632G>C	synonymous_variant	0.56	levofloxacin
gyrA	8933	c.1632G>C	synonymous_variant	0.56	moxifloxacin
gyrA	8936	c.1635G>A	synonymous_variant	0.55	levofloxacin
gyrA	8936	c.1635G>A	synonymous_variant	0.55	moxifloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.56	levofloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.56	moxifloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.58	levofloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.58	moxifloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	0.61	levofloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	0.61	moxifloxacin
gyrA	8983	p.Cys561Ser	missense_variant	0.67	levofloxacin
gyrA	8983	p.Cys561Ser	missense_variant	0.67	moxifloxacin
gyrA	8987	c.1686C>G	synonymous_variant	0.62	levofloxacin
gyrA	8987	c.1686C>G	synonymous_variant	0.62	moxifloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.59	levofloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.59	moxifloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.65	levofloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.65	moxifloxacin
gyrA	8998	p.Leu566Trp	missense_variant	0.67	levofloxacin	Uncertain significance
gyrA	8998	p.Leu566Trp	missense_variant	0.67	moxifloxacin	Uncertain significance
gyrA	9003	c.1702C>T	synonymous_variant	0.7	levofloxacin
gyrA	9003	c.1702C>T	synonymous_variant	0.7	moxifloxacin
gyrA	9023	c.1722A>C	synonymous_variant	0.72	levofloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	0.72	moxifloxacin	Not assoc w R - Interim
gyrA	9029	c.1728T>A	synonymous_variant	0.68	levofloxacin
gyrA	9029	c.1728T>A	synonymous_variant	0.68	moxifloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.67	levofloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.67	moxifloxacin
gyrA	9035	c.1734G>C	synonymous_variant	0.64	levofloxacin	Not assoc w R - Interim
gyrA	9035	c.1734G>C	synonymous_variant	0.64	moxifloxacin
gyrA	9038	c.1737C>G	synonymous_variant	0.64	levofloxacin
gyrA	9038	c.1737C>G	synonymous_variant	0.64	moxifloxacin
gyrA	9050	p.Asp583Glu	missense_variant	0.59	levofloxacin	Uncertain significance
gyrA	9050	p.Asp583Glu	missense_variant	0.59	moxifloxacin	Uncertain significance
gyrA	9051	c.1750T>C	synonymous_variant	0.57	levofloxacin
gyrA	9051	c.1750T>C	synonymous_variant	0.57	moxifloxacin
gyrA	9062	c.1761C>A	synonymous_variant	0.49	levofloxacin
gyrA	9062	c.1761C>A	synonymous_variant	0.49	moxifloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.41	levofloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.41	moxifloxacin
gyrA	9074	c.1773G>C	synonymous_variant	0.4	levofloxacin
gyrA	9074	c.1773G>C	synonymous_variant	0.4	moxifloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.38	levofloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.38	moxifloxacin
gyrA	9161	c.1860C>G	synonymous_variant	0.27	levofloxacin
gyrA	9161	c.1860C>G	synonymous_variant	0.27	moxifloxacin
gyrA	9167	c.1866C>T	synonymous_variant	0.35	levofloxacin
gyrA	9167	c.1866C>T	synonymous_variant	0.35	moxifloxacin
gyrA	9182	c.1881T>C	synonymous_variant	0.46	levofloxacin	Not assoc w R - Interim
gyrA	9182	c.1881T>C	synonymous_variant	0.46	moxifloxacin	Not assoc w R - Interim
gyrA	9183	p.Arg628Lys	missense_variant	0.44	levofloxacin
gyrA	9183	p.Arg628Lys	missense_variant	0.44	moxifloxacin
gyrA	9197	c.1896G>C	synonymous_variant	0.53	levofloxacin
gyrA	9197	c.1896G>C	synonymous_variant	0.53	moxifloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.67	levofloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.67	moxifloxacin
gyrA	9236	c.1935G>C	synonymous_variant	0.66	levofloxacin
gyrA	9236	c.1935G>C	synonymous_variant	0.66	moxifloxacin
gyrA	9242	c.1941A>C	synonymous_variant	0.65	levofloxacin
gyrA	9242	c.1941A>C	synonymous_variant	0.65	moxifloxacin
gyrA	9248	c.1947G>C	synonymous_variant	0.55	levofloxacin
gyrA	9248	c.1947G>C	synonymous_variant	0.55	moxifloxacin
gyrA	9252	p.Val651Ile	missense_variant	0.56	levofloxacin	Uncertain significance
gyrA	9252	p.Val651Ile	missense_variant	0.56	moxifloxacin	Uncertain significance
gyrA	9266	c.1965C>T	synonymous_variant	0.57	levofloxacin
gyrA	9266	c.1965C>T	synonymous_variant	0.57	moxifloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.38	levofloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.38	moxifloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.33	levofloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.33	moxifloxacin
gyrA	9296	c.1995T>C	synonymous_variant	0.36	levofloxacin	Not assoc w R - Interim
gyrA	9296	c.1995T>C	synonymous_variant	0.36	moxifloxacin	Not assoc w R - Interim
gyrA	9304	p.Gly668Glu	missense_variant	1.0	levofloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	moxifloxacin
gyrA	9308	p.Asp669Glu	missense_variant	0.43	levofloxacin
gyrA	9308	p.Asp669Glu	missense_variant	0.43	moxifloxacin
gyrA	9315	c.2014C>T	synonymous_variant	0.47	levofloxacin	Not assoc w R - Interim
gyrA	9315	c.2014C>T	synonymous_variant	0.47	moxifloxacin	Not assoc w R - Interim
gyrA	9326	c.2025G>A	synonymous_variant	0.54	levofloxacin
gyrA	9326	c.2025G>A	synonymous_variant	0.54	moxifloxacin
gyrA	9338	c.2037G>A	synonymous_variant	0.58	levofloxacin
gyrA	9338	c.2037G>A	synonymous_variant	0.58	moxifloxacin
gyrA	9341	c.2040C>G	synonymous_variant	0.59	levofloxacin
gyrA	9341	c.2040C>G	synonymous_variant	0.59	moxifloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.56	levofloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.56	moxifloxacin
gyrA	9368	c.2067G>A	synonymous_variant	0.59	levofloxacin
gyrA	9368	c.2067G>A	synonymous_variant	0.59	moxifloxacin
gyrA	9383	c.2082T>C	synonymous_variant	0.54	levofloxacin
gyrA	9383	c.2082T>C	synonymous_variant	0.54	moxifloxacin
gyrA	9386	c.2085T>C	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	0.54	moxifloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	0.48	levofloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	0.48	moxifloxacin	Not assoc w R - Interim
gyrA	9398	c.2097T>C	synonymous_variant	0.47	levofloxacin
gyrA	9398	c.2097T>C	synonymous_variant	0.47	moxifloxacin
Rv0010c	13729	c.-171G>C	upstream_gene_variant	0.52	isoniazid
Rv0010c	13762	c.-204G>C	upstream_gene_variant	0.52	isoniazid
Rv0010c	13771	c.-213T>C	upstream_gene_variant	0.5	isoniazid
Rv0010c	13792	c.-234G>C	upstream_gene_variant	0.5	isoniazid
Rv0010c	13903	c.-345A>G	upstream_gene_variant	0.38	isoniazid
Rv0010c	13909	c.-351G>C	upstream_gene_variant	0.47	isoniazid
fgd1	490905	c.123T>C	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fgd1	490911	c.129T>G	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fgd1	490921	p.Gln47Glu	missense_variant	0.69	clofazimine
					pretomanid
					delamanid
fgd1	490929	c.147C>G	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fgd1	490932	c.150T>C	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fgd1	490971	c.189A>G	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fgd1	490974	c.192T>C	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fgd1	490980	p.Asn66Lys	missense_variant	0.69	clofazimine
					pretomanid
					delamanid
fgd1	490983	c.201G>A	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fgd1	490988	p.Leu69Gln	missense_variant	0.69	clofazimine
					pretomanid
					delamanid
fgd1	490995	c.213C>G	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fgd1	490998	c.216T>G	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fgd1	491007	c.225G>C	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fgd1	491013	c.231C>G	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fgd1	491016	c.234C>G	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491106	c.324T>C	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fgd1	491109	c.327G>A	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fgd1	491110	p.Ala110Ser	missense_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491115	c.333G>C	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fgd1	491121	c.339A>G	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fgd1	491136	c.354C>T	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fgd1	491144	p.Ala121Glu	missense_variant	0.67	clofazimine
					pretomanid
					delamanid
fgd1	491166	c.384G>T	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491168	p.Phe129Tyr	missense_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491178	c.396G>C	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491181	c.399T>C	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fgd1	491191	p.Gly137Arg	missense_variant	0.68	clofazimine
					pretomanid
					delamanid
fgd1	491310	c.528C>G	synonymous_variant	0.83	clofazimine
					pretomanid
					delamanid
fgd1	491320	p.Ala180Gln	missense_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491325	c.543G>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fgd1	491340	c.558C>A	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fgd1	491364	c.582T>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fgd1	491367	c.585G>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
mshA	574595	c.-753A>G	upstream_gene_variant	0.58	ethionamide
mshA	574595	c.-753A>G	upstream_gene_variant	0.58	isoniazid
mshA	574607	c.-741G>A	upstream_gene_variant	0.76	ethionamide
mshA	574607	c.-741G>A	upstream_gene_variant	0.76	isoniazid
mshA	574616	c.-732G>C	upstream_gene_variant	0.74	ethionamide
mshA	574616	c.-732G>C	upstream_gene_variant	0.74	isoniazid
mshA	574640	c.-708G>A	upstream_gene_variant	0.76	ethionamide
mshA	574640	c.-708G>A	upstream_gene_variant	0.76	isoniazid
mshA	574646	c.-702G>A	upstream_gene_variant	0.74	ethionamide
mshA	574646	c.-702G>A	upstream_gene_variant	0.74	isoniazid
mshA	574650	c.-698A>C	upstream_gene_variant	0.73	ethionamide
mshA	574650	c.-698A>C	upstream_gene_variant	0.73	isoniazid
mshA	574667	c.-681G>A	upstream_gene_variant	0.75	ethionamide
mshA	574667	c.-681G>A	upstream_gene_variant	0.75	isoniazid
mshA	574673	c.-675A>G	upstream_gene_variant	0.75	ethionamide
mshA	574673	c.-675A>G	upstream_gene_variant	0.75	isoniazid
mshA	574676	c.-672G>C	upstream_gene_variant	0.74	ethionamide
mshA	574676	c.-672G>C	upstream_gene_variant	0.74	isoniazid
mshA	574683	c.-665T>C	upstream_gene_variant	0.74	ethionamide
mshA	574683	c.-665T>C	upstream_gene_variant	0.74	isoniazid	Uncertain significance
mshA	574688	c.-660G>C	upstream_gene_variant	0.62	ethionamide	Uncertain significance
mshA	574688	c.-660G>C	upstream_gene_variant	0.62	isoniazid	Uncertain significance
mshA	574694	c.-654C>G	upstream_gene_variant	0.61	ethionamide
mshA	574694	c.-654C>G	upstream_gene_variant	0.61	isoniazid
mshA	574712	c.-636A>G	upstream_gene_variant	0.47	ethionamide
mshA	574712	c.-636A>G	upstream_gene_variant	0.47	isoniazid
mshA	574718	c.-630A>G	upstream_gene_variant	0.48	ethionamide
mshA	574718	c.-630A>G	upstream_gene_variant	0.48	isoniazid
mshA	574721	c.-627C>A	upstream_gene_variant	0.5	ethionamide
mshA	574721	c.-627C>A	upstream_gene_variant	0.5	isoniazid
mshA	574724	c.-624T>C	upstream_gene_variant	0.5	ethionamide
mshA	574724	c.-624T>C	upstream_gene_variant	0.5	isoniazid
mshA	574727	c.-621G>C	upstream_gene_variant	0.5	ethionamide
mshA	574727	c.-621G>C	upstream_gene_variant	0.5	isoniazid
mshA	574731	c.-617A>G	upstream_gene_variant	0.5	ethionamide
mshA	574731	c.-617A>G	upstream_gene_variant	0.5	isoniazid
mshA	574739	c.-609T>C	upstream_gene_variant	0.5	ethionamide
mshA	574739	c.-609T>C	upstream_gene_variant	0.5	isoniazid
mshA	575000	c.-348C>G	upstream_gene_variant	0.58	ethionamide
mshA	575000	c.-348C>G	upstream_gene_variant	0.58	isoniazid
mshA	575009	c.-339T>C	upstream_gene_variant	0.65	ethionamide
mshA	575009	c.-339T>C	upstream_gene_variant	0.65	isoniazid
mshA	575011	c.-337G>A	upstream_gene_variant	0.67	ethionamide
mshA	575011	c.-337G>A	upstream_gene_variant	0.67	isoniazid
mshA	575022	c.-326C>T	upstream_gene_variant	0.73	ethionamide
mshA	575022	c.-326C>T	upstream_gene_variant	0.73	isoniazid
mshA	575034	c.-314_-312delTTAinsCG	upstream_gene_variant	0.75	ethionamide
mshA	575034	c.-314_-312delTTAinsCG	upstream_gene_variant	0.75	isoniazid
mshA	575042	c.-306T>C	upstream_gene_variant	0.77	ethionamide
mshA	575042	c.-306T>C	upstream_gene_variant	0.77	isoniazid
mshA	575045	c.-303C>G	upstream_gene_variant	0.76	ethionamide
mshA	575045	c.-303C>G	upstream_gene_variant	0.76	isoniazid
mshA	575051	c.-297A>G	upstream_gene_variant	0.75	ethionamide	Uncertain significance
mshA	575051	c.-297A>G	upstream_gene_variant	0.75	isoniazid	Uncertain significance
mshA	575052	c.-296G>C	upstream_gene_variant	0.74	ethionamide
mshA	575052	c.-296G>C	upstream_gene_variant	0.74	isoniazid
mshA	575072	c.-276G>C	upstream_gene_variant	0.68	ethionamide
mshA	575072	c.-276G>C	upstream_gene_variant	0.68	isoniazid
mshA	575075	c.-273T>C	upstream_gene_variant	0.66	ethionamide
mshA	575075	c.-273T>C	upstream_gene_variant	0.66	isoniazid	Uncertain significance
mshA	575081	c.-267A>G	upstream_gene_variant	0.66	ethionamide
mshA	575081	c.-267A>G	upstream_gene_variant	0.66	isoniazid
mshA	575087	c.-261C>G	upstream_gene_variant	0.65	ethionamide
mshA	575087	c.-261C>G	upstream_gene_variant	0.65	isoniazid
mshA	575109	c.-239G>T	upstream_gene_variant	0.32	ethionamide
mshA	575109	c.-239G>T	upstream_gene_variant	0.32	isoniazid
mshA	575114	c.-234G>A	upstream_gene_variant	0.29	ethionamide
mshA	575114	c.-234G>A	upstream_gene_variant	0.29	isoniazid	Uncertain significance
mshA	575117	c.-231T>C	upstream_gene_variant	0.28	ethionamide
mshA	575117	c.-231T>C	upstream_gene_variant	0.28	isoniazid
mshA	575118	c.-230A>G	upstream_gene_variant	0.28	ethionamide
mshA	575118	c.-230A>G	upstream_gene_variant	0.28	isoniazid	Uncertain significance
mshA	575123	c.-225A>G	upstream_gene_variant	0.27	ethionamide
mshA	575123	c.-225A>G	upstream_gene_variant	0.27	isoniazid
mshA	575124	c.-224_-222delGGGinsCT	upstream_gene_variant	0.27	ethionamide
mshA	575124	c.-224_-222delGGGinsCT	upstream_gene_variant	0.27	isoniazid
mshA	575144	c.-204T>G	upstream_gene_variant	0.53	ethionamide
mshA	575144	c.-204T>G	upstream_gene_variant	0.53	isoniazid
mshA	575695	c.348C>G	synonymous_variant	0.51	ethionamide
mshA	575695	c.348C>G	synonymous_variant	0.51	isoniazid	Not assoc w R - Interim
mshA	575704	c.357T>C	synonymous_variant	0.59	ethionamide
mshA	575704	c.357T>C	synonymous_variant	0.59	isoniazid
mshA	575705	c.358T>C	synonymous_variant	0.59	ethionamide
mshA	575705	c.358T>C	synonymous_variant	0.59	isoniazid
mshA	575713	c.366G>A	synonymous_variant	0.57	ethionamide
mshA	575713	c.366G>A	synonymous_variant	0.57	isoniazid
mshA	575719	c.372C>T	synonymous_variant	0.51	ethionamide	Not assoc w R - Interim
mshA	575719	c.372C>T	synonymous_variant	0.51	isoniazid	Not assoc w R - Interim
mshA	575734	c.387T>G	synonymous_variant	0.66	ethionamide
mshA	575734	c.387T>G	synonymous_variant	0.66	isoniazid
mshA	575746	c.399C>G	synonymous_variant	0.69	ethionamide
mshA	575746	c.399C>G	synonymous_variant	0.69	isoniazid
mshA	575767	c.420G>A	synonymous_variant	0.58	ethionamide
mshA	575767	c.420G>A	synonymous_variant	0.58	isoniazid
mshA	575771	p.Val142Ser	missense_variant	0.56	ethionamide
mshA	575771	p.Val142Ser	missense_variant	0.56	isoniazid
mshA	575779	p.Glu144Asp	missense_variant	0.56	ethionamide
mshA	575779	p.Glu144Asp	missense_variant	0.56	isoniazid
mshA	575780	c.433_435delCCGinsGC	frameshift_variant&missense_variant	0.56	ethionamide	Uncertain significance
mshA	575780	c.433_435delCCGinsGC	frameshift_variant&missense_variant	0.56	isoniazid	Uncertain significance
mshA	575821	c.474G>C	synonymous_variant	0.61	ethionamide
mshA	575821	c.474G>C	synonymous_variant	0.61	isoniazid
mshA	575824	c.477T>G	synonymous_variant	0.59	ethionamide
mshA	575824	c.477T>G	synonymous_variant	0.59	isoniazid
mshA	575842	c.495G>C	synonymous_variant	0.69	ethionamide
mshA	575842	c.495G>C	synonymous_variant	0.69	isoniazid
mshA	575845	c.498C>G	synonymous_variant	0.71	ethionamide
mshA	575845	c.498C>G	synonymous_variant	0.71	isoniazid
mshA	575848	c.501C>T	synonymous_variant	0.73	ethionamide
mshA	575848	c.501C>T	synonymous_variant	0.73	isoniazid
mshA	575851	c.504C>G	synonymous_variant	0.72	ethionamide
mshA	575851	c.504C>G	synonymous_variant	0.72	isoniazid
mshA	575864	c.517T>C	synonymous_variant	0.73	ethionamide
mshA	575864	c.517T>C	synonymous_variant	0.73	isoniazid
mshA	575884	c.537G>C	synonymous_variant	0.61	ethionamide
mshA	575884	c.537G>C	synonymous_variant	0.61	isoniazid
mshA	575887	c.540G>T	synonymous_variant	0.57	ethionamide
mshA	575887	c.540G>T	synonymous_variant	0.57	isoniazid
mshA	575890	c.543C>G	synonymous_variant	0.55	ethionamide
mshA	575890	c.543C>G	synonymous_variant	0.55	isoniazid
mshA	575893	c.546C>G	synonymous_variant	0.55	ethionamide
mshA	575893	c.546C>G	synonymous_variant	0.55	isoniazid
mshA	575899	c.552G>A	synonymous_variant	0.59	ethionamide
mshA	575899	c.552G>A	synonymous_variant	0.59	isoniazid
mshA	576625	c.1278C>G	synonymous_variant	0.29	ethionamide
mshA	576625	c.1278C>G	synonymous_variant	0.29	isoniazid
mshA	576634	c.1287G>C	synonymous_variant	0.35	ethionamide
mshA	576634	c.1287G>C	synonymous_variant	0.35	isoniazid
mshA	576659	c.1312T>C	synonymous_variant	0.36	ethionamide
mshA	576659	c.1312T>C	synonymous_variant	0.36	isoniazid
mshA	576667	c.1320T>C	synonymous_variant	0.34	ethionamide
mshA	576667	c.1320T>C	synonymous_variant	0.34	isoniazid
mshA	576670	c.1323T>C	synonymous_variant	0.35	ethionamide
mshA	576670	c.1323T>C	synonymous_variant	0.35	isoniazid
mshA	576676	c.1329T>G	synonymous_variant	0.38	ethionamide
mshA	576676	c.1329T>G	synonymous_variant	0.38	isoniazid
ccsA	619588	c.-303C>G	upstream_gene_variant	0.28	capreomycin
					amikacin
					kanamycin
ccsA	619591	c.-300G>C	upstream_gene_variant	0.29	capreomycin
					amikacin
					kanamycin
ccsA	619594	c.-297G>A	upstream_gene_variant	0.34	capreomycin
					amikacin
					kanamycin
ccsA	619624	c.-267C>T	upstream_gene_variant	0.56	capreomycin
					amikacin
					kanamycin
ccsA	619634	c.-257_-255delTCCinsGTG	upstream_gene_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	619654	c.-237A>G	upstream_gene_variant	0.53	capreomycin
					amikacin
					kanamycin
ccsA	619669	c.-222G>C	upstream_gene_variant	0.4	capreomycin
					amikacin
					kanamycin
ccsA	619672	c.-219A>C	upstream_gene_variant	0.4	capreomycin
					amikacin
					kanamycin
ccsA	619676	c.-215C>T	upstream_gene_variant	0.34	capreomycin
					amikacin
					kanamycin
ccsA	619684	c.-207G>A	upstream_gene_variant	0.29	capreomycin
					amikacin
					kanamycin
ccsA	619912	p.Val8Ile	missense_variant	0.53	capreomycin
					amikacin
					kanamycin
ccsA	619923	c.33C>G	synonymous_variant	0.62	capreomycin
					amikacin
					kanamycin
ccsA	619935	c.45C>T	synonymous_variant	0.59	capreomycin
					amikacin
					kanamycin
ccsA	619953	c.63C>G	synonymous_variant	0.59	capreomycin
					amikacin
					kanamycin
ccsA	619984	c.94C>T	synonymous_variant	0.46	capreomycin
					amikacin
					kanamycin
ccsA	620197	p.Gln103Met	missense_variant	0.4	capreomycin
					amikacin
					kanamycin
ccsA	620238	c.348G>C	synonymous_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	620245	c.355T>C	synonymous_variant	0.57	capreomycin
					amikacin
					kanamycin
ccsA	620249	p.Ser120Cys	missense_variant	0.57	capreomycin
					amikacin
					kanamycin
ccsA	620253	c.363G>C	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620254	c.364_366delCTCinsTG	frameshift_variant&missense_variant	0.53	capreomycin
					amikacin
					kanamycin
ccsA	620271	c.381C>G	synonymous_variant	0.48	capreomycin
					amikacin
					kanamycin
ccsA	620284	p.Ala132Pro	missense_variant	0.29	capreomycin
					amikacin
					kanamycin
ccsA	620307	c.417C>G	synonymous_variant	0.32	capreomycin
					amikacin
					kanamycin
ccsA	620317	c.427_429delGTCinsCG	frameshift_variant&missense_variant	0.44	capreomycin
					amikacin
					kanamycin
ccsA	620325	c.435G>C	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620343	c.453G>C	synonymous_variant	0.44	capreomycin
					amikacin
					kanamycin
ccsA	620349	c.459A>T	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620362	p.Ala158Thr	missense_variant	0.43	capreomycin
					amikacin
					kanamycin
ccsA	620367	c.477T>C	synonymous_variant	0.44	capreomycin
					amikacin
					kanamycin
ccsA	620373	c.483C>G	synonymous_variant	0.4	capreomycin
					amikacin
					kanamycin
ccsA	620376	c.486G>C	synonymous_variant	0.4	capreomycin
					amikacin
					kanamycin
ccsA	620388	c.498A>C	synonymous_variant	0.27	capreomycin
					amikacin
					kanamycin
ccsA	620389	c.499C>T	synonymous_variant	0.27	capreomycin
					amikacin
					kanamycin
ccsA	620394	c.504G>A	synonymous_variant	0.3	capreomycin
					amikacin
					kanamycin
ccsA	620400	c.510C>T	synonymous_variant	0.31	capreomycin
					amikacin
					kanamycin
ccsA	620613	c.723C>G	synonymous_variant	0.6	capreomycin
					amikacin
					kanamycin
ccsA	620625	c.735A>C	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620631	c.741T>G	synonymous_variant	0.68	capreomycin
					amikacin
					kanamycin
ccsA	620649	c.759A>G	synonymous_variant	0.68	capreomycin
					amikacin
					kanamycin
ccsA	620652	c.762C>G	synonymous_variant	0.69	capreomycin
					amikacin
					kanamycin
ccsA	620661	c.771C>G	synonymous_variant	0.73	capreomycin
					amikacin
					kanamycin
ccsA	620685	c.795G>A	synonymous_variant	0.69	capreomycin	Not assoc w R - Interim
					amikacin
					kanamycin	Not assoc w R - Interim
ccsA	620698	p.Val270Ile	missense_variant	0.66	capreomycin
					amikacin
					kanamycin
ccsA	620712	c.822G>C	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620721	c.831G>A	synonymous_variant	0.6	capreomycin
					amikacin
					kanamycin
ccsA	620733	c.843G>C	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620748	c.858T>C	synonymous_variant	0.67	capreomycin
					amikacin
					kanamycin
ccsA	620778	c.888T>C	synonymous_variant	0.71	capreomycin
					amikacin
					kanamycin
ccsA	620781	c.891C>G	synonymous_variant	0.68	capreomycin
					amikacin
					kanamycin
ccsA	620783	p.Ala298Val	missense_variant	0.69	capreomycin
					amikacin
					kanamycin
ccsA	620787	c.897C>A	synonymous_variant	0.7	capreomycin
					amikacin
					kanamycin
ccsA	620796	c.906C>G	synonymous_variant	0.7	capreomycin
					amikacin
					kanamycin
Rv0565c	656265	c.1206G>C	synonymous_variant	0.35	ethionamide
Rv0565c	656268	p.Met401Ile	missense_variant	0.43	ethionamide
Rv0565c	656292	c.1179G>C	synonymous_variant	0.5	ethionamide
Rv0565c	656304	c.1167T>C	synonymous_variant	0.47	ethionamide
Rv0565c	656307	c.1164G>C	synonymous_variant	0.47	ethionamide
Rv0565c	656310	c.1161T>C	synonymous_variant	0.47	ethionamide
Rv0565c	656322	c.1149C>T	synonymous_variant	0.46	ethionamide
Rv0565c	656325	c.1146C>G	synonymous_variant	0.46	ethionamide
Rv0565c	656334	c.1137A>G	synonymous_variant	0.46	ethionamide
Rv0565c	657210	c.261C>T	synonymous_variant	0.47	ethionamide	Not assoc w R - Interim
Rv0565c	657213	c.258C>T	synonymous_variant	0.5	ethionamide
Rv0565c	657219	p.Ala84Val	missense_variant	0.53	ethionamide
Rv0565c	657233	p.Ile80Val	missense_variant	0.67	ethionamide
Rv0565c	657240	c.229_231delGAAinsAG	frameshift_variant&synonymous_variant	0.63	ethionamide	Uncertain significance
Rv0565c	657252	c.219G>C	synonymous_variant	0.74	ethionamide
Rv0565c	657255	c.216G>A	synonymous_variant	0.76	ethionamide
Rv0565c	657259	p.Tyr71Phe	missense_variant	0.78	ethionamide
Rv0565c	657279	c.192C>T	synonymous_variant	0.82	ethionamide
Rv0565c	657294	c.177C>A	synonymous_variant	0.79	ethionamide
Rv0565c	657306	c.165C>T	synonymous_variant	0.71	ethionamide
Rv0565c	657312	c.159C>T	synonymous_variant	0.68	ethionamide
Rv0565c	657318	c.153T>C	synonymous_variant	0.6	ethionamide
Rv0565c	657324	c.147C>G	synonymous_variant	0.5	ethionamide
Rv0565c	657644	c.-174G>C	upstream_gene_variant	0.48	ethionamide
Rv0565c	657649	c.-179G>A	upstream_gene_variant	0.59	ethionamide
Rv0565c	657659	c.-189G>A	upstream_gene_variant	0.64	ethionamide
Rv0565c	657668	c.-198C>T	upstream_gene_variant	0.72	ethionamide
Rv0565c	657678	c.-208A>C	upstream_gene_variant	0.68	ethionamide
Rv0565c	657689	c.-220_-219delCAinsAG	upstream_gene_variant	0.7	ethionamide
Rv0565c	657695	c.-225C>G	upstream_gene_variant	0.67	ethionamide
Rv0565c	657704	c.-234G>A	upstream_gene_variant	0.61	ethionamide
Rv0565c	657725	c.-255G>A	upstream_gene_variant	0.55	ethionamide
hadA	731708	c.-222G>A	upstream_gene_variant	0.34	isoniazid
hadA	731711	c.-219T>C	upstream_gene_variant	0.42	isoniazid
hadA	731726	c.-204C>G	upstream_gene_variant	0.56	isoniazid
hadA	731729	c.-201C>T	upstream_gene_variant	0.57	isoniazid
hadA	731753	c.-177A>C	upstream_gene_variant	0.68	isoniazid
hadA	731756	c.-174C>T	upstream_gene_variant	0.69	isoniazid
hadA	731774	c.-156T>C	upstream_gene_variant	0.73	isoniazid
hadA	731786	c.-144C>G	upstream_gene_variant	0.8	isoniazid
hadA	731789	c.-141A>G	upstream_gene_variant	0.73	isoniazid
hadA	731807	c.-123C>T	upstream_gene_variant	0.67	isoniazid
hadA	731819	c.-111G>C	upstream_gene_variant	0.62	isoniazid
hadA	731843	c.-87T>C	upstream_gene_variant	0.54	isoniazid
hadA	731852	c.-78A>G	upstream_gene_variant	0.48	isoniazid
hadA	732280	c.351C>G	synonymous_variant	0.22	isoniazid
hadA	732305	c.376_378delATCinsGG	frameshift_variant&missense_variant	0.34	isoniazid	Uncertain significance
hadA	732308	p.Val127Ile	missense_variant	0.33	isoniazid
hadA	732314	p.Asn129Asp	missense_variant	0.38	isoniazid
hadA	732319	c.390G>A	synonymous_variant	0.47	isoniazid
hadA	732321	p.Glu131Ala	missense_variant	0.47	isoniazid
hadA	732329	p.Leu134Ile	missense_variant	0.6	isoniazid
hadA	732346	c.417T>C	synonymous_variant	0.7	isoniazid
hadA	732378	c.450_452dupAGA	disruptive_inframe_insertion	0.9	isoniazid
hadA	732396	p.Gly156Ala	missense_variant	0.88	isoniazid
hadA	732398	p.Ala157Thr	missense_variant	0.87	isoniazid
nusG	734053	c.-201A>T	upstream_gene_variant	0.42	rifampicin
nusG	734078	c.-176C>G	upstream_gene_variant	0.65	rifampicin	Uncertain significance
nusG	734093	c.-161A>G	upstream_gene_variant	0.64	rifampicin
nusG	734111	c.-143A>G	upstream_gene_variant	0.62	rifampicin
nusG	734114	c.-140A>G	upstream_gene_variant	0.61	rifampicin
nusG	734120	c.-134T>C	upstream_gene_variant	0.62	rifampicin	Uncertain significance
nusG	734129	c.-125G>C	upstream_gene_variant	0.58	rifampicin
nusG	734224	c.-30G>C	upstream_gene_variant	0.38	rifampicin
nusG	734225	c.-29C>T	upstream_gene_variant	0.38	rifampicin
nusG	734229	c.-25A>T	upstream_gene_variant	0.4	rifampicin
nusG	734230	c.-24G>A	upstream_gene_variant	0.4	rifampicin
nusG	734233	c.-21T>C	upstream_gene_variant	0.4	rifampicin
nusG	734236	c.-18C>T	upstream_gene_variant	0.45	rifampicin
nusG	734403	c.150C>T	synonymous_variant	0.65	rifampicin
nusG	734407	c.154_156delGTTinsAC	frameshift_variant&missense_variant	0.65	rifampicin
nusG	734421	c.168A>C	synonymous_variant	0.71	rifampicin
nusG	734424	c.171G>C	synonymous_variant	0.69	rifampicin
nusG	734439	c.186C>G	synonymous_variant	0.69	rifampicin
nusG	734451	c.198G>C	synonymous_variant	0.71	rifampicin
nusG	734454	c.201A>G	synonymous_variant	0.69	rifampicin
nusG	734472	c.219T>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
nusG	734475	c.222T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
nusG	734478	c.225C>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
nusG	734499	c.246G>C	synonymous_variant	0.72	rifampicin
nusG	734520	c.267C>A	synonymous_variant	0.76	rifampicin
nusG	734532	c.279A>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
nusG	734541	c.288A>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
nusG	734559	c.306T>C	synonymous_variant	0.73	rifampicin
nusG	734571	c.318C>G	synonymous_variant	0.66	rifampicin
nusG	734580	c.327T>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
nusG	734589	c.336G>C	synonymous_variant	0.59	rifampicin
nusG	734595	c.342C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
nusG	734596	c.343T>C	synonymous_variant	0.56	rifampicin
nusG	734610	c.357C>G	synonymous_variant	0.5	rifampicin
nusG	734814	c.561G>C	synonymous_variant	0.67	rifampicin
nusG	734820	c.567A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
nusG	734826	c.573A>G	synonymous_variant	0.74	rifampicin
nusG	734829	c.576C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
nusG	734841	c.588G>T	synonymous_variant	0.77	rifampicin
nusG	734853	c.600A>G	synonymous_variant	0.79	rifampicin
nusG	734854	c.601T>C	synonymous_variant	0.79	rifampicin
nusG	734870	p.Ser206Asn	missense_variant	0.83	rifampicin
nusG	734895	c.642A>G	synonymous_variant	0.82	rifampicin
nusG	734910	c.657C>G	synonymous_variant	0.79	rifampicin
nusG	734913	c.660C>G	synonymous_variant	0.79	rifampicin
nusG	734931	c.678A>T	synonymous_variant	0.67	rifampicin
nusG	734940	c.687G>A	synonymous_variant	0.61	rifampicin
nusG	734943	c.690G>C	synonymous_variant	0.54	rifampicin
nusG	734950	p.Gly233Thr	missense_variant	0.46	rifampicin
rpoB	760043	c.237C>T	synonymous_variant	0.35	rifampicin
rpoB	760046	c.240G>C	synonymous_variant	0.39	rifampicin
rpoB	760056	c.250_252delCTCinsTG	frameshift_variant&missense_variant	0.46	rifampicin
rpoB	760070	c.264T>G	synonymous_variant	0.6	rifampicin
rpoB	760091	c.285G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	760101	c.295T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	760112	c.306T>C	synonymous_variant	0.72	rifampicin
rpoB	760118	c.312T>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	760121	c.315T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	760130	p.Asp108Glu	missense_variant	0.82	rifampicin	Uncertain significance
rpoB	760139	c.333A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	760142	c.336C>G	synonymous_variant	0.76	rifampicin
rpoB	760145	c.339C>G	synonymous_variant	0.77	rifampicin
rpoB	760181	c.375T>A	synonymous_variant	0.82	rifampicin
rpoB	760184	c.378A>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	760196	c.390C>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	760235	c.429T>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	760244	c.438G>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	760274	c.468G>A	synonymous_variant	0.81	rifampicin
rpoB	760295	c.489C>T	synonymous_variant	0.79	rifampicin
rpoB	760307	c.501T>C	synonymous_variant	0.77	rifampicin
rpoB	760310	c.504G>C	synonymous_variant	0.75	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	0.64	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.67	rifampicin
rpoB	760337	c.531C>G	synonymous_variant	0.57	rifampicin
rpoB	760340	c.534G>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	760358	c.552C>G	synonymous_variant	0.6	rifampicin
rpoB	760361	c.555T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	760370	c.564C>G	synonymous_variant	0.57	rifampicin
rpoB	760376	p.Asp190Glu	missense_variant	0.55	rifampicin	Uncertain significance
rpoB	760380	p.Thr192Leu	missense_variant	0.55	rifampicin
rpoB	760412	c.606C>T	synonymous_variant	0.58	rifampicin
rpoB	760418	c.612G>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	760424	c.618C>G	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	760457	c.651C>T	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	760472	c.666C>T	synonymous_variant	0.67	rifampicin
rpoB	760475	c.669A>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	760478	c.672C>T	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>T	synonymous_variant	0.65	rifampicin
rpoB	760484	c.678A>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	760493	c.687C>G	synonymous_variant	0.74	rifampicin
rpoB	760520	c.714C>G	synonymous_variant	0.61	rifampicin
rpoB	760522	p.Ser239Asn	missense_variant	0.61	rifampicin	Uncertain significance
rpoB	760526	c.720G>A	synonymous_variant	0.6	rifampicin
rpoB	760532	c.726T>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243Thr	missense_variant	0.53	rifampicin
rpoB	760547	c.741G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760563	p.Arg253Met	missense_variant	0.68	rifampicin	Uncertain significance
rpoB	760591	p.Val262Ala	missense_variant	0.78	rifampicin
rpoB	760601	c.795C>T	synonymous_variant	0.83	rifampicin
rpoB	760611	c.805T>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	760622	c.816C>T	synonymous_variant	0.83	rifampicin
rpoB	760646	c.840C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	760649	c.843G>C	synonymous_variant	0.84	rifampicin
rpoB	760655	c.849A>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	760661	c.855A>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	760667	c.861G>A	synonymous_variant	0.84	rifampicin
rpoB	760670	c.864G>C	synonymous_variant	0.85	rifampicin
rpoB	760674	c.868T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	760679	c.873A>G	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoB	760683	c.877T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	760724	c.918T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	760730	c.924T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	760748	c.942C>G	synonymous_variant	0.68	rifampicin
rpoB	760757	c.951T>C	synonymous_variant	0.61	rifampicin
rpoB	760759	p.Val318Ala	missense_variant	0.61	rifampicin
rpoB	760769	c.963C>G	synonymous_variant	0.69	rifampicin
rpoB	760793	c.987A>G	synonymous_variant	0.77	rifampicin
rpoB	760805	c.999G>C	synonymous_variant	0.85	rifampicin
rpoB	760817	c.1011A>G	synonymous_variant	0.84	rifampicin
rpoB	760820	c.1014T>C	synonymous_variant	0.85	rifampicin
rpoB	760826	c.1020C>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	760830	c.1024T>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoB	760841	c.1035T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	760845	c.1039_1041delACCinsCG	frameshift_variant&missense_variant	0.87	rifampicin
rpoB	760856	c.1050C>G	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoB	760886	c.1080A>G	synonymous_variant	0.81	rifampicin
rpoB	760916	c.1110C>G	synonymous_variant	0.71	rifampicin
rpoB	760919	c.1113C>G	synonymous_variant	0.76	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.74	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.74	rifampicin
rpoB	760937	c.1131G>A	synonymous_variant	0.75	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	760973	c.1167G>C	synonymous_variant	0.8	rifampicin
rpoB	760982	c.1176G>T	synonymous_variant	0.78	rifampicin
rpoB	760985	c.1179G>T	synonymous_variant	0.78	rifampicin
rpoB	760991	c.1185G>T	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	761006	c.1200C>T	synonymous_variant	0.82	rifampicin
rpoB	761015	c.1209G>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.83	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	761051	c.1245G>T	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	761060	c.1254C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761063	c.1257C>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761096	c.1290G>C	synonymous_variant	0.82	rifampicin
rpoB	761097	c.1291_1293delAGCinsTCG	synonymous_variant	0.81	rifampicin
rpoB	761102	c.1296A>G	synonymous_variant	0.81	rifampicin
rpoB	761132	c.1326G>T	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	761168	c.1362C>G	synonymous_variant	0.74	rifampicin
rpoB	761180	c.1374A>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	761189	c.1383T>G	synonymous_variant	0.71	rifampicin
rpoB	761192	c.1386C>G	synonymous_variant	0.7	rifampicin
rpoB	761195	c.1389G>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	761198	c.1392G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	761240	c.1434C>T	synonymous_variant	0.81	rifampicin
rpoB	761249	c.1443A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	761255	c.1449T>C	synonymous_variant	0.82	rifampicin
rpoB	761261	c.1455G>T	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761264	c.1458C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	761282	c.1476C>G	synonymous_variant	0.83	rifampicin
rpoB	761327	c.1521A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761345	c.1539G>T	synonymous_variant	0.82	rifampicin
rpoB	761354	c.1548C>T	synonymous_variant	0.82	rifampicin
rpoB	761360	c.1554T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	761362	p.Ser519Thr	missense_variant	0.79	rifampicin
rpoB	761374	p.Val523Glu	missense_variant	0.78	rifampicin
rpoB	761414	c.1608A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	761423	c.1617T>C	synonymous_variant	0.67	rifampicin
rpoB	761432	c.1626C>T	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	761435	c.1629T>C	synonymous_variant	0.59	rifampicin
rpoB	761438	c.1632G>C	synonymous_variant	0.6	rifampicin
rpoB	761444	c.1638T>C	synonymous_variant	0.58	rifampicin
rpoB	761452	p.Val549Glu	missense_variant	0.5	rifampicin
rpoB	761457	p.Pro551Ser	missense_variant	0.51	rifampicin
rpoB	761465	c.1659G>A	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	761471	c.1665C>T	synonymous_variant	0.51	rifampicin
rpoB	761477	c.1671C>T	synonymous_variant	0.55	rifampicin
rpoB	761492	c.1686G>C	synonymous_variant	0.66	rifampicin
rpoB	761504	c.1698C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	761510	c.1704T>C	synonymous_variant	0.81	rifampicin
rpoB	761531	c.1725C>G	synonymous_variant	0.83	rifampicin
rpoB	761537	c.1731C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	761558	c.1752C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	761570	c.1764T>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	761606	c.1800C>G	synonymous_variant	0.82	rifampicin
rpoB	761612	c.1806G>T	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>A	synonymous_variant	0.81	rifampicin
rpoB	761648	c.1842T>C	synonymous_variant	0.8	rifampicin
rpoB	761666	c.1860G>C	synonymous_variant	0.76	rifampicin
rpoB	761690	c.1884G>C	synonymous_variant	0.75	rifampicin
rpoB	761723	c.1917_1919delAGAinsC	frameshift_variant&missense_variant	0.53	rifampicin
rpoB	761732	c.1926C>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	761735	c.1929C>G	synonymous_variant	0.58	rifampicin
rpoB	761750	c.1944G>C	synonymous_variant	0.68	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.7	rifampicin
rpoB	761772	p.His656Ala	missense_variant	0.62	rifampicin
rpoB	761778	p.Asn658Asp	missense_variant	0.62	rifampicin
rpoB	761791	p.Arg662His	missense_variant	0.6	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.66	rifampicin
rpoB	761828	c.2022C>T	synonymous_variant	0.68	rifampicin
rpoB	761834	c.2028T>C	synonymous_variant	0.64	rifampicin
rpoB	761837	c.2031C>T	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoB	761848	p.Cys681Ser	missense_variant	0.58	rifampicin
rpoB	761852	c.2046C>G	synonymous_variant	0.59	rifampicin
rpoB	761858	c.2052G>C	synonymous_variant	0.61	rifampicin
rpoB	761873	c.2067A>C	synonymous_variant	0.75	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.78	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	0.74	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	0.72	rifampicin
rpoB	761913	c.2107_2109delGACinsCA	frameshift_variant&missense_variant	0.71	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	0.72	rifampicin
rpoB	761921	c.2115C>T	synonymous_variant	0.75	rifampicin
rpoB	761930	c.2124G>C	synonymous_variant	0.8	rifampicin
rpoB	761954	c.2148C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	762008	c.2202C>G	synonymous_variant	0.82	rifampicin
rpoB	762014	c.2208C>T	synonymous_variant	0.82	rifampicin
rpoB	762047	c.2241G>A	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.84	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.79	rifampicin
rpoB	762134	c.2328C>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	762143	c.2337T>C	synonymous_variant	0.77	rifampicin
rpoB	762167	c.2361T>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	762233	c.2427G>T	synonymous_variant	0.73	rifampicin
rpoB	762254	c.2448T>G	synonymous_variant	0.77	rifampicin
rpoB	762257	c.2451C>G	synonymous_variant	0.76	rifampicin
rpoB	762266	c.2460T>C	synonymous_variant	0.77	rifampicin
rpoB	762278	c.2472C>T	synonymous_variant	0.79	rifampicin
rpoB	762281	c.2475G>A	synonymous_variant	0.78	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	762317	c.2511A>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	762338	c.2532T>C	synonymous_variant	0.82	rifampicin
rpoB	762341	c.2535G>C	synonymous_variant	0.82	rifampicin
rpoB	762347	c.2541T>C	synonymous_variant	0.83	rifampicin
rpoB	762362	p.Glu852Asp	missense_variant	0.81	rifampicin
rpoB	762369	c.2563T>C	synonymous_variant	0.79	rifampicin
rpoC	762395	c.-975G>C	upstream_gene_variant	0.74	rifampicin
rpoC	762398	c.-972T>C	upstream_gene_variant	0.71	rifampicin
rpoC	762401	c.-969G>C	upstream_gene_variant	0.71	rifampicin
rpoB	762404	c.2598T>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	762410	c.-960T>C	upstream_gene_variant	0.74	rifampicin
rpoB	762416	c.2610A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	762431	c.2625C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	762449	c.2643C>A	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762470	c.2664G>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	762491	c.2685T>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoC	762509	c.-861T>G	upstream_gene_variant	0.77	rifampicin
rpoB	762510	c.2704_2706delGCCinsCG	frameshift_variant&missense_variant	0.76	rifampicin
rpoC	762533	c.-837T>C	upstream_gene_variant	0.79	rifampicin
rpoC	762536	c.-834T>C	upstream_gene_variant	0.78	rifampicin
rpoC	762537	c.-833T>C	upstream_gene_variant	0.78	rifampicin
rpoC	762551	c.-819C>T	upstream_gene_variant	0.7	rifampicin
rpoC	762563	c.-807G>A	upstream_gene_variant	0.61	rifampicin
rpoC	762581	c.-789T>C	upstream_gene_variant	0.43	rifampicin
rpoC	762587	c.-783G>A	upstream_gene_variant	0.27	rifampicin
rpoC	762776	c.-594C>G	upstream_gene_variant	0.43	rifampicin
rpoB	762782	c.2976T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762789	p.Leu995Met	missense_variant	0.64	rifampicin	Uncertain significance
rpoC	762794	c.-576C>G	upstream_gene_variant	0.64	rifampicin
rpoB	762795	p.Asp997Asn	missense_variant	0.66	rifampicin	Uncertain significance
rpoB	762812	c.3006C>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762813	p.Met1003Val	missense_variant	0.79	rifampicin
rpoB	762818	c.3012C>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	762827	c.3021G>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	762833	c.3027C>T	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	762857	c.3051C>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	762860	c.-510G>T	upstream_gene_variant	0.8	rifampicin
rpoC	762902	c.-468C>T	upstream_gene_variant	0.82	rifampicin
rpoC	762917	c.-453C>T	upstream_gene_variant	0.81	rifampicin
rpoB	762929	c.3123G>T	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	762962	c.3156C>T	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	762983	c.-387C>G	upstream_gene_variant	0.82	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>C	synonymous_variant	0.75	rifampicin	Not assoc w R
rpoB	763034	c.3228C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	763082	c.3276C>T	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	763085	c.3279C>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	763127	c.3321G>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	763166	c.3360A>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	763169	c.-201A>G	upstream_gene_variant	0.73	rifampicin
rpoC	763202	c.-168A>C	upstream_gene_variant	0.73	rifampicin
rpoC	763205	c.-165G>T	upstream_gene_variant	0.7	rifampicin
rpoC	763206	c.-164_-162delAGTinsTCC	upstream_gene_variant	0.69	rifampicin
rpoC	763226	c.-144A>G	upstream_gene_variant	0.72	rifampicin
rpoB	763238	c.3432T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	763241	c.-129G>A	upstream_gene_variant	0.73	rifampicin
rpoC	763250	c.-120C>T	upstream_gene_variant	0.66	rifampicin
rpoC	763253	c.-117G>T	upstream_gene_variant	0.65	rifampicin
rpoC	763262	c.-108C>A	upstream_gene_variant	0.53	rifampicin
rpoC	763265	c.-105G>A	upstream_gene_variant	0.42	rifampicin
rpoB	763283	c.3477T>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoC	763284	c.-86C>T	upstream_gene_variant	0.38	rifampicin
rpoC	763289	c.-81C>G	upstream_gene_variant	0.38	rifampicin
rpoC	763351	c.-19T>C	upstream_gene_variant	0.38	rifampicin	Uncertain significance
rpoC	763352	c.-18T>A	upstream_gene_variant	0.42	rifampicin	Uncertain significance
rpoC	763402	c.33C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	763409	c.40_42delCTTinsTG	frameshift_variant&missense_variant	0.76	rifampicin
rpoC	763414	c.45T>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	763441	c.72C>T	synonymous_variant	0.75	rifampicin
rpoC	763444	c.75T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	763486	c.117T>G	synonymous_variant	0.78	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	763603	c.234C>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	763618	c.249C>T	synonymous_variant	0.82	rifampicin
rpoC	763636	c.267T>C	synonymous_variant	0.82	rifampicin
rpoC	763660	c.291T>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	763669	c.300C>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	763675	c.306C>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	763703	c.334_336delTCGinsAGC	synonymous_variant	0.79	rifampicin
rpoC	763709	c.340C>T	synonymous_variant	0.82	rifampicin
rpoC	763714	c.345G>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	763726	c.357C>T	synonymous_variant	0.87	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.86	rifampicin
rpoC	763741	c.372C>T	synonymous_variant	0.85	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.85	rifampicin
rpoC	763765	c.396T>G	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoC	763771	c.402C>T	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	763780	c.411C>G	synonymous_variant	0.85	rifampicin
rpoC	763792	p.Glu141Asp	missense_variant	0.85	rifampicin
rpoC	763801	c.432C>G	synonymous_variant	0.83	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	763836	p.Ala156Val	missense_variant	0.82	rifampicin
rpoC	763851	p.Ala161Gly	missense_variant	0.76	rifampicin
rpoC	763855	c.486C>T	synonymous_variant	0.81	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.79	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.75	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	0.79	rifampicin
rpoC	763879	c.510A>G	synonymous_variant	0.76	rifampicin
rpoC	763888	c.519G>C	synonymous_variant	0.76	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	0.75	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	0.76	rifampicin
rpoC	763936	c.567C>G	synonymous_variant	0.81	rifampicin
rpoC	763939	c.570G>A	synonymous_variant	0.79	rifampicin
rpoC	763951	c.582G>A	synonymous_variant	0.82	rifampicin
rpoC	763963	c.594C>G	synonymous_variant	0.83	rifampicin
rpoC	763967	p.Gly200Ser	missense_variant	0.84	rifampicin
rpoC	763972	c.603C>T	synonymous_variant	0.84	rifampicin
rpoC	763987	c.618C>T	synonymous_variant	0.77	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.79	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	764011	c.642T>C	synonymous_variant	0.84	rifampicin
rpoC	764024	c.655T>C	synonymous_variant	0.85	rifampicin
rpoC	764040	p.Ser224Thr	missense_variant	0.82	rifampicin
rpoC	764044	c.675T>G	synonymous_variant	0.81	rifampicin
rpoC	764059	c.690G>T	synonymous_variant	0.86	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.85	rifampicin
rpoC	764101	c.732C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	764140	c.771C>T	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	764159	c.790C>T	synonymous_variant	0.83	rifampicin
rpoC	764167	c.798G>A	synonymous_variant	0.83	rifampicin
rpoC	764188	c.819A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	764195	p.Ser276Ile	missense_variant	0.79	rifampicin
rpoC	764215	c.846A>C	synonymous_variant	0.84	rifampicin
rpoC	764218	c.849C>T	synonymous_variant	0.87	rifampicin
rpoC	764242	c.873C>T	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	764245	c.876C>A	synonymous_variant	0.83	rifampicin
rpoC	764246	c.877_879delCTCinsTG	frameshift_variant&missense_variant	0.83	rifampicin
rpoC	764263	c.894G>C	synonymous_variant	0.86	rifampicin
rpoC	764266	c.897T>C	synonymous_variant	0.86	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764293	c.924G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	764317	c.948C>G	synonymous_variant	0.82	rifampicin
rpoC	764320	c.951C>G	synonymous_variant	0.82	rifampicin
rpoC	764365	c.996C>T	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	764377	c.1008C>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	764380	c.1011G>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	764381	c.1012_1013delTCinsAG	synonymous_variant	0.75	rifampicin
rpoC	764387	c.1018_1020delTTGinsCC	frameshift_variant&missense_variant	0.73	rifampicin
rpoC	764405	c.1036_1038delAGGinsCC	frameshift_variant&missense_variant	0.77	rifampicin
rpoC	764428	c.1059G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	0.68	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.69	rifampicin
rpoC	764452	c.1083T>C	synonymous_variant	0.7	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	764497	c.1128A>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	764503	c.1134G>C	synonymous_variant	0.67	rifampicin
rpoC	764521	c.1152T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	764536	c.1167G>T	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764539	c.1170C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	764554	c.1185C>T	synonymous_variant	0.75	rifampicin
rpoC	764575	c.1206T>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	764578	c.1209C>G	synonymous_variant	0.76	rifampicin
rpoC	764593	c.1224C>T	synonymous_variant	0.76	rifampicin
rpoC	764605	c.1236G>A	synonymous_variant	0.81	rifampicin
rpoC	764626	c.1257C>T	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	764668	c.1299C>T	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764686	c.1317C>T	synonymous_variant	0.89	rifampicin
rpoC	764746	c.1377G>C	synonymous_variant	0.8	rifampicin
rpoC	764749	c.1380G>C	synonymous_variant	0.8	rifampicin
rpoC	764752	c.1383G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	764782	c.1413C>T	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	764797	c.1428G>C	synonymous_variant	0.78	rifampicin
rpoC	764803	c.1434C>G	synonymous_variant	0.76	rifampicin
rpoC	764809	c.1440C>T	synonymous_variant	0.77	rifampicin	Not assoc w R
rpoC	764815	c.1446A>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	764858	c.1489T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	764887	c.1518G>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519_1521delTTGinsCC	frameshift_variant&missense_variant	0.63	rifampicin
rpoC	764896	c.1527C>T	synonymous_variant	0.64	rifampicin
rpoC	764902	c.1533C>T	synonymous_variant	0.66	rifampicin
rpoC	764911	c.1542A>G	synonymous_variant	0.73	rifampicin
rpoC	764923	c.1554A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	764932	c.1563C>G	synonymous_variant	0.75	rifampicin
rpoC	764948	c.1579T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	765007	c.1638T>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	765008	c.1639T>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	765013	c.1644C>T	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	765019	c.1650A>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	765065	c.1696C>T	synonymous_variant	0.43	rifampicin
rpoC	765073	c.1704G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	765076	c.1707A>G	synonymous_variant	0.5	rifampicin
rpoC	765079	c.1710T>C	synonymous_variant	0.5	rifampicin
rpoC	765082	c.1713G>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	765089	c.1720T>C	synonymous_variant	0.49	rifampicin	Not assoc w R - Interim
rpoC	765103	c.1734G>A	synonymous_variant	0.49	rifampicin	Not assoc w R - Interim
rpoC	765121	c.1752G>T	synonymous_variant	0.55	rifampicin
rpoC	765208	c.1839T>C	synonymous_variant	0.32	rifampicin
rpoC	765223	c.1854G>C	synonymous_variant	0.4	rifampicin
rpoC	765233	c.1864_1866delGCCinsTG	frameshift_variant&missense_variant	0.4	rifampicin
rpoC	765247	c.1878C>G	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	765248	c.1879T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	765251	c.1882_1884delAGCinsTCG	synonymous_variant	0.42	rifampicin
rpoC	765278	c.1909C>T	synonymous_variant	0.61	rifampicin
rpoC	765283	c.1914C>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	765292	c.1923G>T	synonymous_variant	0.52	rifampicin
rpoC	765300	p.Val644Ala	missense_variant	0.52	rifampicin	Uncertain significance
rpoC	765319	c.1950A>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	765328	p.His653Gln	missense_variant	0.75	rifampicin	Uncertain significance
rpoC	765330	p.Ser654Asn	missense_variant	0.75	rifampicin	Uncertain significance
rpoC	765334	c.1965C>T	synonymous_variant	0.74	rifampicin
rpoC	765343	c.1974G>A	synonymous_variant	0.74	rifampicin
rpoC	765352	c.1983G>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	765367	c.1998C>G	synonymous_variant	0.68	rifampicin
rpoC	765370	c.2001G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	765383	p.Met672Leu	missense_variant	0.67	rifampicin	Uncertain significance
rpoC	765391	c.2022C>T	synonymous_variant	0.66	rifampicin
rpoC	765406	c.2037G>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765409	c.2040T>C	synonymous_variant	0.71	rifampicin
rpoC	765412	c.2043T>C	synonymous_variant	0.71	rifampicin
rpoC	765421	c.2052C>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	765452	c.2083_2085delGCCinsTG	frameshift_variant&missense_variant	0.72	rifampicin
rpoC	765466	c.2097C>T	synonymous_variant	0.72	rifampicin
rpoC	765478	c.2109T>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	765493	c.2124G>C	synonymous_variant	0.7	rifampicin
rpoC	765499	c.2130C>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765508	c.2139C>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765517	c.2148C>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	0.75	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	0.76	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	0.78	rifampicin
rpoC	765562	c.2193G>C	synonymous_variant	0.75	rifampicin
rpoC	765578	c.2209C>T	synonymous_variant	0.76	rifampicin
rpoC	765622	p.Glu751Asp	missense_variant	0.76	rifampicin
rpoC	765625	c.2256C>T	synonymous_variant	0.77	rifampicin
rpoC	765628	c.2259G>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	765658	c.2289C>T	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	765670	c.2301C>T	synonymous_variant	0.85	rifampicin
rpoC	765728	p.Gln787Lys	missense_variant	0.79	rifampicin
rpoC	765734	c.2365T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	765739	c.2370G>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	765752	p.Asp795Ser	missense_variant	0.62	rifampicin
rpoC	765772	c.2403C>G	synonymous_variant	0.59	rifampicin
rpoC	765784	c.2415C>G	synonymous_variant	0.65	rifampicin
rpoC	765790	c.2421C>T	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	765793	c.2424C>G	synonymous_variant	0.66	rifampicin
rpoC	765796	c.2427C>T	synonymous_variant	0.67	rifampicin
rpoC	765814	c.2445A>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765826	c.2457T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	0.79	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	0.79	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	765904	c.2535C>T	synonymous_variant	0.76	rifampicin
rpoC	765934	c.2565C>T	synonymous_variant	0.76	rifampicin
rpoC	765952	c.2583G>T	synonymous_variant	0.78	rifampicin
rpoC	765967	c.2598C>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	765982	c.2613C>G	synonymous_variant	0.79	rifampicin
rpoC	765994	c.2625A>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	766012	c.2643C>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	766021	c.2652G>C	synonymous_variant	0.77	rifampicin
rpoC	766061	p.Val898Ile	missense_variant	0.78	rifampicin
rpoC	766082	p.Ala905Gln	missense_variant	0.61	rifampicin
rpoC	766093	c.2724C>A	synonymous_variant	0.6	rifampicin
rpoC	766095	p.Thr909Ser	missense_variant	0.59	rifampicin
rpoC	766105	c.2736C>T	synonymous_variant	0.63	rifampicin
rpoC	766123	c.2754C>A	synonymous_variant	0.56	rifampicin
rpoC	766129	c.2760C>G	synonymous_variant	0.49	rifampicin
rpoC	766135	c.2766G>A	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	766141	c.2772C>T	synonymous_variant	0.31	rifampicin
rpoC	766142	c.2773C>T	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	766147	c.2778C>T	synonymous_variant	0.31	rifampicin
rpoC	766148	p.Thr927Ala	missense_variant	0.31	rifampicin	Uncertain significance
rpoC	766168	c.2799C>G	synonymous_variant	0.31	rifampicin
rpoC	766270	c.2901G>C	synonymous_variant	0.48	rifampicin
rpoC	766273	c.2904T>C	synonymous_variant	0.48	rifampicin
rpoC	766274	p.Ala969Thr	missense_variant	0.48	rifampicin
rpoC	766280	c.2911_2913delAGCinsGT	frameshift_variant&missense_variant	0.5	rifampicin
rpoC	766288	c.2919C>G	synonymous_variant	0.6	rifampicin
rpoC	766309	c.2940G>A	synonymous_variant	0.72	rifampicin
rpoC	766315	c.2946C>G	synonymous_variant	0.76	rifampicin
rpoC	766321	c.2952C>G	synonymous_variant	0.77	rifampicin
rpoC	766348	c.2979A>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	766369	c.3000C>G	synonymous_variant	0.77	rifampicin
rpoC	766381	c.3012C>T	synonymous_variant	0.76	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	0.78	rifampicin
rpoC	766393	c.3024C>G	synonymous_variant	0.78	rifampicin
rpoC	766402	c.3033C>G	synonymous_variant	0.79	rifampicin
rpoC	766408	c.3039C>T	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	766426	c.3057C>T	synonymous_variant	0.77	rifampicin
rpoC	766456	c.3087C>G	synonymous_variant	0.8	rifampicin
rpoC	766486	c.3117A>G	synonymous_variant	0.78	rifampicin
rpoC	766492	c.3123T>C	synonymous_variant	0.79	rifampicin
rpoC	766522	c.3153C>G	synonymous_variant	0.75	rifampicin
rpoC	766528	c.3159T>C	synonymous_variant	0.75	rifampicin
rpoC	766530	p.Arg1054Gln	missense_variant	0.76	rifampicin
rpoC	766549	c.3180G>C	synonymous_variant	0.73	rifampicin
rpoC	766573	c.3204T>C	synonymous_variant	0.71	rifampicin
rpoC	766585	c.3216T>C	synonymous_variant	0.71	rifampicin
rpoC	766594	c.3225G>C	synonymous_variant	0.72	rifampicin
rpoC	766607	p.Ile1080Leu	missense_variant	0.74	rifampicin
rpoC	766630	c.3261G>T	synonymous_variant	0.77	rifampicin
rpoC	766660	c.3291G>A	synonymous_variant	0.84	rifampicin
rpoC	766666	c.3297C>G	synonymous_variant	0.83	rifampicin
rpoC	766672	c.3303T>C	synonymous_variant	0.85	rifampicin
rpoC	766700	c.3331C>T	synonymous_variant	0.8	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	0.83	rifampicin
rpoC	766733	c.3364C>T	synonymous_variant	0.82	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	0.82	rifampicin
rpoC	766741	c.3372G>C	synonymous_variant	0.82	rifampicin
rpoC	766750	c.3381C>G	synonymous_variant	0.81	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	0.8	rifampicin
rpoC	766798	c.3429C>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	766801	c.3432C>G	synonymous_variant	0.75	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	766843	c.3474T>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.76	rifampicin
rpoC	766876	c.3507C>T	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	766883	c.3514_3516delTCGinsGC	frameshift_variant&missense_variant	0.78	rifampicin
rpoC	766894	c.3525T>C	synonymous_variant	0.72	rifampicin
rpoC	766895	c.3526T>C	synonymous_variant	0.73	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.75	rifampicin
rpoC	766903	c.3534C>T	synonymous_variant	0.78	rifampicin
rpoC	766918	c.3549C>T	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	766933	c.3564A>G	synonymous_variant	0.71	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	766963	c.3594T>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	766996	c.3627C>G	synonymous_variant	0.69	rifampicin
rpoC	767002	c.3633G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	767059	c.3690T>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.75	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.82	rifampicin
rpoC	767158	c.3789T>A	synonymous_variant	0.7	rifampicin
rpoC	767167	c.3798C>G	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.67	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	767206	c.3837C>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	767209	c.3840T>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoC	767221	c.3852C>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	767230	c.3861G>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	767233	c.3864T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	767263	c.3894T>G	synonymous_variant	0.6	rifampicin
rpoC	767264	p.Ala1299Gln	missense_variant	0.58	rifampicin
rpoC	767278	c.3909T>C	synonymous_variant	0.59	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	775961	c.2520C>G	synonymous_variant	0.3	clofazimine
mmpL5	775961	c.2520C>G	synonymous_variant	0.3	bedaquiline
mmpL5	775966	p.Ala839Ser	missense_variant	0.37	clofazimine
mmpL5	775966	p.Ala839Ser	missense_variant	0.37	bedaquiline
mmpL5	775975	c.2506T>C	synonymous_variant	0.56	clofazimine
mmpL5	775975	c.2506T>C	synonymous_variant	0.56	bedaquiline
mmpL5	775981	p.Leu834Met	missense_variant	0.59	clofazimine
mmpL5	775981	p.Leu834Met	missense_variant	0.59	bedaquiline
mmpL5	775997	c.2484T>C	synonymous_variant	0.53	clofazimine
mmpL5	775997	c.2484T>C	synonymous_variant	0.53	bedaquiline
mmpL5	776000	c.2479_2481delCTGinsAC	frameshift_variant&missense_variant	0.45	clofazimine	Uncertain significance
mmpL5	776000	c.2479_2481delCTGinsAC	frameshift_variant&missense_variant	0.45	bedaquiline	Uncertain significance
mmpL5	776009	c.2472A>G	synonymous_variant	0.58	clofazimine
mmpL5	776009	c.2472A>G	synonymous_variant	0.58	bedaquiline
mmpL5	776030	c.2451G>T	synonymous_variant	0.63	clofazimine
mmpL5	776030	c.2451G>T	synonymous_variant	0.63	bedaquiline
mmpL5	776036	c.2445G>T	synonymous_variant	0.59	clofazimine
mmpL5	776036	c.2445G>T	synonymous_variant	0.59	bedaquiline
mmpL5	776039	c.2442C>G	synonymous_variant	0.52	clofazimine
mmpL5	776039	c.2442C>G	synonymous_variant	0.52	bedaquiline
rpsL	781134	c.-426T>C	upstream_gene_variant	0.44	streptomycin
rpsL	781138	c.-422C>G	upstream_gene_variant	0.43	streptomycin
rpsL	781143	c.-417T>C	upstream_gene_variant	0.43	streptomycin
rpsL	781152	c.-408G>A	upstream_gene_variant	0.59	streptomycin
rpsL	781164	c.-396T>C	upstream_gene_variant	0.64	streptomycin
rpsL	781170	c.-390G>C	upstream_gene_variant	0.64	streptomycin
rpsL	781173	c.-387A>G	upstream_gene_variant	0.64	streptomycin
rpsL	781174	c.-386C>T	upstream_gene_variant	0.64	streptomycin
rpsL	781185	c.-375T>C	upstream_gene_variant	0.67	streptomycin
rpsL	781188	c.-372G>C	upstream_gene_variant	0.68	streptomycin
rpsL	781189	c.-371T>C	upstream_gene_variant	0.66	streptomycin
rpsL	781206	c.-354C>T	upstream_gene_variant	0.54	streptomycin
rpsL	781209	c.-351C>G	upstream_gene_variant	0.52	streptomycin
rpsL	781224	c.-336T>C	upstream_gene_variant	0.35	streptomycin
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rpsL	781571	c.12C>T	synonymous_variant	0.63	streptomycin
rpsL	781595	c.36T>C	synonymous_variant	0.65	streptomycin
rpsL	781598	c.39G>C	synonymous_variant	0.66	streptomycin
rpsL	781605	p.Ile16Val	missense_variant	0.67	streptomycin	Uncertain significance
rpsL	781608	p.Ser17Ala	missense_variant	0.68	streptomycin
rpsL	781628	c.69T>C	synonymous_variant	0.76	streptomycin	Not assoc w R - Interim
rpsL	781655	c.96T>C	synonymous_variant	0.75	streptomycin
rpsL	781658	c.99A>G	synonymous_variant	0.74	streptomycin
rpsL	781682	c.123T>C	synonymous_variant	0.79	streptomycin
rpsL	781715	c.156T>C	synonymous_variant	0.79	streptomycin
rpsL	781718	c.159C>G	synonymous_variant	0.79	streptomycin
rpsL	781721	c.162C>T	synonymous_variant	0.8	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	0.85	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	0.85	streptomycin
rpsL	781751	c.192G>C	synonymous_variant	0.8	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	0.85	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	0.85	streptomycin
rpsL	781766	c.207C>T	synonymous_variant	0.84	streptomycin	Not assoc w R - Interim
rpsL	781772	c.213C>G	synonymous_variant	0.81	streptomycin
rpsL	781793	c.234G>C	synonymous_variant	0.8	streptomycin
rpsL	781808	c.249C>T	synonymous_variant	0.78	streptomycin
rpsL	781832	c.273T>G	synonymous_variant	0.77	streptomycin
rpsL	781835	c.276T>C	synonymous_variant	0.76	streptomycin	Not assoc w R - Interim
rpsL	781859	c.300T>G	synonymous_variant	0.78	streptomycin
rpsL	781865	c.306G>C	synonymous_variant	0.77	streptomycin
rpsL	781868	c.309T>C	synonymous_variant	0.74	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	0.72	streptomycin
rpsL	781883	c.324G>A	synonymous_variant	0.74	streptomycin
rpsL	781886	c.327C>T	synonymous_variant	0.73	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	0.75	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.74	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	0.78	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.74	streptomycin	Uncertain significance
rpsL	781933	c.374G>A	splice_region_variant&stop_retained_variant	0.75	streptomycin
rplC	800201	c.-608A>G	upstream_gene_variant	0.47	linezolid
rplC	800209	c.-600C>T	upstream_gene_variant	0.49	linezolid
rplC	800212	c.-597C>A	upstream_gene_variant	0.5	linezolid
rplC	800216	c.-593A>G	upstream_gene_variant	0.46	linezolid
rplC	800222	c.-587G>A	upstream_gene_variant	0.45	linezolid
rplC	800225	c.-584T>C	upstream_gene_variant	0.43	linezolid
rplC	800238	c.-571A>G	upstream_gene_variant	0.47	linezolid
rplC	800252	c.-557C>A	upstream_gene_variant	0.44	linezolid
rplC	800272	c.-537C>T	upstream_gene_variant	0.36	linezolid
rplC	800278	c.-531A>G	upstream_gene_variant	0.24	linezolid
rplC	800329	c.-480C>T	upstream_gene_variant	0.29	linezolid
rplC	800341	c.-468G>C	upstream_gene_variant	0.29	linezolid
rplC	800348	c.-461_-460insA	upstream_gene_variant	0.3	linezolid
rplC	800358	c.-450delT	upstream_gene_variant	0.27	linezolid
rplC	800386	c.-423T>C	upstream_gene_variant	0.23	linezolid
rplC	800516	c.-293G>T	upstream_gene_variant	0.68	linezolid
rplC	800540	c.-269T>C	upstream_gene_variant	0.76	linezolid
rplC	800546	c.-263T>C	upstream_gene_variant	0.8	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.8	linezolid
rplC	800579	c.-230C>T	upstream_gene_variant	0.78	linezolid
rplC	800582	c.-227C>T	upstream_gene_variant	0.77	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.76	linezolid
rplC	800618	c.-191T>C	upstream_gene_variant	0.75	linezolid
rplC	800621	c.-188G>A	upstream_gene_variant	0.75	linezolid
rplC	800627	c.-182C>T	upstream_gene_variant	0.74	linezolid
rplC	800648	c.-161A>G	upstream_gene_variant	0.72	linezolid
rplC	800654	c.-155T>C	upstream_gene_variant	0.73	linezolid
rplC	800693	c.-116A>G	upstream_gene_variant	0.62	linezolid
rplC	800703	c.-106_-104delTTGinsCC	upstream_gene_variant	0.64	linezolid
rplC	800714	c.-95C>T	upstream_gene_variant	0.64	linezolid
rplC	800715	c.-94A>C	upstream_gene_variant	0.64	linezolid
rplC	800723	c.-86C>G	upstream_gene_variant	0.67	linezolid
rplC	800744	c.-65G>C	upstream_gene_variant	0.57	linezolid
rplC	800745	c.-64_-62delCTCinsTG	upstream_gene_variant	0.54	linezolid
rplC	800759	c.-50C>T	upstream_gene_variant	0.51	linezolid
rplC	800762	c.-47T>G	upstream_gene_variant	0.49	linezolid
rplC	800798	c.-11_-8delTGGAinsC	upstream_gene_variant	0.37	linezolid
rplC	800806	c.-3G>T	upstream_gene_variant	0.38	linezolid
rplC	800807	c.-2_-1insT	upstream_gene_variant	0.38	linezolid
rplC	800814	c.6A>G	synonymous_variant	0.41	linezolid
rplC	800815	c.7C>A	synonymous_variant	0.43	linezolid
rplC	800820	c.12G>A	synonymous_variant	0.52	linezolid
rplC	800829	c.21C>G	synonymous_variant	0.69	linezolid
rplC	800844	c.36T>C	synonymous_variant	0.75	linezolid
rplC	800856	c.48A>G	synonymous_variant	0.75	linezolid
rplC	800865	c.57A>G	synonymous_variant	0.73	linezolid
rplC	800867	p.Ser20Asn	missense_variant	0.74	linezolid
rplC	800872	c.64_66delAGAinsCG	frameshift_variant&synonymous_variant	0.77	linezolid
rplC	800877	c.69A>C	synonymous_variant	0.77	linezolid
rplC	800880	c.72A>G	synonymous_variant	0.77	linezolid
rplC	800901	c.93C>G	synonymous_variant	0.75	linezolid
rplC	800910	c.102C>T	synonymous_variant	0.71	linezolid
rplC	800916	c.108A>G	synonymous_variant	0.66	linezolid
rplC	800919	c.111C>G	synonymous_variant	0.65	linezolid
rplC	800931	c.123G>C	synonymous_variant	0.65	linezolid
rplC	800934	c.126C>G	synonymous_variant	0.65	linezolid
rplC	800937	c.129A>G	synonymous_variant	0.62	linezolid
rplC	800946	c.138T>A	synonymous_variant	0.66	linezolid
rplC	800949	c.141T>C	synonymous_variant	0.63	linezolid
rplC	800962	p.Leu52Val	missense_variant	0.5	linezolid
rplC	801171	c.363A>G	synonymous_variant	0.31	linezolid
rplC	801180	c.372C>G	synonymous_variant	0.43	linezolid
rplC	801195	c.387G>C	synonymous_variant	0.56	linezolid
rplC	801201	c.393C>T	synonymous_variant	0.57	linezolid
rplC	801207	c.399C>T	synonymous_variant	0.55	linezolid
rplC	801210	c.402T>C	synonymous_variant	0.57	linezolid
rplC	801222	c.414T>C	synonymous_variant	0.68	linezolid
rplC	801228	c.420T>C	synonymous_variant	0.68	linezolid
rplC	801231	c.423C>T	synonymous_variant	0.7	linezolid
rplC	801246	c.438C>T	synonymous_variant	0.69	linezolid
rplC	801285	c.477G>A	synonymous_variant	0.62	linezolid
rplC	801309	c.501C>G	synonymous_variant	0.63	linezolid
rplC	801312	c.504G>C	synonymous_variant	0.61	linezolid
rplC	801324	c.516T>C	synonymous_variant	0.48	linezolid
rplC	801330	c.522G>T	synonymous_variant	0.5	linezolid
rplC	801333	c.525G>C	synonymous_variant	0.52	linezolid
rplC	801339	c.531T>G	synonymous_variant	0.41	linezolid
rplC	801341	p.Leu178Gln	missense_variant	0.43	linezolid
rplC	801348	c.540T>G	synonymous_variant	0.44	linezolid
rplC	801349	p.Leu181Val	missense_variant	0.44	linezolid
rplC	801357	c.549T>C	synonymous_variant	0.46	linezolid
rplC	801385	c.577C>T	synonymous_variant	0.59	linezolid
rplC	801402	c.594T>C	synonymous_variant	0.62	linezolid
rplC	801405	c.597T>C	synonymous_variant	0.62	linezolid
rplC	801408	c.600C>A	synonymous_variant	0.61	linezolid
rplC	801423	c.615G>C	synonymous_variant	0.62	linezolid
rplC	801426	c.618C>T	synonymous_variant	0.61	linezolid
rplC	801427	p.Met207Val	missense_variant	0.61	linezolid
rplC	801437	p.Ser210Thr	missense_variant	0.61	linezolid
rplC	801461	c.653G>A	splice_region_variant&stop_retained_variant	0.55	linezolid
fbiC	1303470	c.540T>G	synonymous_variant	0.51	clofazimine
					pretomanid
					delamanid
fbiC	1303488	c.558G>C	synonymous_variant	0.64	clofazimine
					pretomanid
					delamanid
fbiC	1303506	c.576C>T	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1303512	c.582T>C	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1303534	p.Ser202Ala	missense_variant	0.78	clofazimine
					pretomanid
					delamanid
fbiC	1303538	p.Arg203Leu	missense_variant	0.77	clofazimine
					pretomanid
					delamanid
fbiC	1303545	c.615A>G	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1303575	c.645G>C	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fbiC	1303578	c.648G>A	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fbiC	1303584	c.654C>G	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fbiC	1303596	c.666G>C	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fbiC	1303605	c.675C>G	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1303608	c.678G>A	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1303614	c.684C>T	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1303617	c.687C>G	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1303620	c.690C>T	synonymous_variant	0.59	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1303629	c.699C>T	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1303632	c.702T>G	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fbiC	1303659	c.729T>C	synonymous_variant	0.66	clofazimine
					pretomanid
					delamanid
fbiC	1303661	p.Val244Ala	missense_variant	0.66	clofazimine
					pretomanid
					delamanid
fbiC	1303674	c.744C>G	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fbiC	1303686	c.756C>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1303704	c.774T>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1303708	c.778T>C	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1303719	c.789C>T	synonymous_variant	0.25	clofazimine
					pretomanid
					delamanid
fbiC	1303869	c.939T>C	synonymous_variant	0.41	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1303881	c.951G>C	synonymous_variant	0.31	clofazimine
					pretomanid
					delamanid
fbiC	1303890	c.960G>C	synonymous_variant	0.28	clofazimine
					pretomanid
					delamanid
fbiC	1303893	c.963G>A	synonymous_variant	0.27	clofazimine
					pretomanid
					delamanid
fbiC	1303913	p.Gly328Asp	missense_variant	0.26	clofazimine
					pretomanid
					delamanid
fbiC	1303923	c.993C>T	synonymous_variant	0.25	clofazimine
					pretomanid
					delamanid
fbiC	1303986	c.1056C>T	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304001	c.1071C>T	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304013	c.1083G>C	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1304019	c.1089C>T	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304022	c.1092T>C	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304046	c.1116C>G	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304055	c.1125C>T	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304178	c.1248G>A	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304184	c.1254G>T	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fbiC	1304190	c.1260G>C	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304196	c.1266C>A	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304205	c.1275C>A	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304220	c.1290G>C	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1304222	p.Val431Ala	missense_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1304226	c.1296C>G	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1304227	p.Met433Leu	missense_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1304478	c.1548G>C	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1304481	c.1551T>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304496	c.1566T>A	synonymous_variant	0.53	clofazimine
					pretomanid
					delamanid
fbiC	1304499	c.1569T>G	synonymous_variant	0.56	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1304502	c.1572G>C	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304526	c.1596T>G	synonymous_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1304532	c.1602G>C	synonymous_variant	0.64	clofazimine
					pretomanid
					delamanid
fbiC	1304533	c.1603T>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1304541	c.1611C>G	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1304544	c.1614T>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1304546	p.Val539Ala	missense_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1304559	p.Glu543Asp	missense_variant	0.7	clofazimine
					pretomanid
					delamanid
fbiC	1304565	c.1635C>G	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fbiC	1304568	c.1638T>C	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fbiC	1304574	c.1644C>G	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fbiC	1304580	c.1650T>C	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304610	c.1680C>G	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fbiC	1304613	c.1683T>A	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiC	1304625	c.1695C>T	synonymous_variant	0.77	clofazimine
					pretomanid
					delamanid
fbiC	1304634	c.1704C>G	synonymous_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1304640	c.1710A>C	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1304646	c.1716T>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1304658	c.1728C>G	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304778	c.1848T>C	synonymous_variant	0.24	clofazimine
					pretomanid
					delamanid
fbiC	1304784	c.1854T>G	synonymous_variant	0.3	clofazimine
					pretomanid
					delamanid
fbiC	1304787	c.1857T>C	synonymous_variant	0.29	clofazimine
					pretomanid
					delamanid
fbiC	1304797	p.Ala623Asn	missense_variant	0.31	clofazimine
					pretomanid
					delamanid
fbiC	1304811	c.1881C>G	synonymous_variant	0.3	clofazimine
					pretomanid
					delamanid
fbiC	1304817	c.1887T>C	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fbiC	1304823	c.1893C>T	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304832	c.1902C>G	synonymous_variant	0.51	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304853	c.1923C>G	synonymous_variant	0.57	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304856	c.1926C>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304868	c.1938G>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1304871	c.1941G>T	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304872	c.1942_1943delAGinsTC	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304875	p.Ile649Val	missense_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1304883	c.1953G>A	synonymous_variant	0.64	clofazimine
					pretomanid
					delamanid
fbiC	1304893	p.Gly655Ser	missense_variant	0.68	clofazimine
					pretomanid
					delamanid
fbiC	1304915	p.Asp662Gly	missense_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304928	c.1998T>C	synonymous_variant	0.77	clofazimine
					pretomanid
					delamanid
fbiC	1304934	c.2004C>G	synonymous_variant	0.77	clofazimine
					pretomanid
					delamanid
fbiC	1304937	c.2007G>C	synonymous_variant	0.77	clofazimine
					pretomanid
					delamanid
fbiC	1304946	c.2016G>C	synonymous_variant	0.79	clofazimine
					pretomanid
					delamanid
fbiC	1304955	c.2025G>A	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304958	c.2028T>G	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304991	c.2061G>C	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiC	1304994	c.2064A>G	synonymous_variant	0.76	clofazimine
					pretomanid
					delamanid
fbiC	1304995	p.Leu689Met	missense_variant	0.76	clofazimine
					pretomanid
					delamanid
fbiC	1305006	c.2076A>G	synonymous_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1305012	c.2082G>C	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fbiC	1305015	c.2085G>C	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fbiC	1305021	c.2091C>A	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1305033	c.2103T>C	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1305039	c.2109G>A	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1305354	c.2424C>T	synonymous_variant	0.63	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1305357	c.2427C>G	synonymous_variant	0.66	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1305361	c.2431C>T	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fbiC	1305393	c.2463T>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1305397	p.Glu823Gln	missense_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1305405	c.2475A>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1305414	c.2484G>A	synonymous_variant	0.53	clofazimine
					pretomanid
					delamanid
fbiC	1305417	c.2487C>G	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1305423	c.2493T>G	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1305426	c.2496G>A	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1305427	c.2497C>T	synonymous_variant	0.36	clofazimine
					pretomanid
					delamanid
fbiC	1305435	c.2505G>C	synonymous_variant	0.36	clofazimine
					pretomanid
					delamanid
sigE	1364839	c.427T>C	synonymous_variant	0.21	pyrazinamide
sigE	1364847	c.435G>C	synonymous_variant	0.33	pyrazinamide
sigE	1364856	c.444C>G	synonymous_variant	0.46	pyrazinamide
sigE	1364868	c.456T>C	synonymous_variant	0.54	pyrazinamide
sigE	1364871	c.459C>G	synonymous_variant	0.6	pyrazinamide
sigE	1364883	c.471G>A	synonymous_variant	0.69	pyrazinamide
sigE	1364889	c.477A>G	synonymous_variant	0.7	pyrazinamide	Not assoc w R - Interim
sigE	1364892	c.480C>G	synonymous_variant	0.69	pyrazinamide
sigE	1364913	c.501C>G	synonymous_variant	0.65	pyrazinamide
sigE	1364919	c.507T>C	synonymous_variant	0.58	pyrazinamide
sigE	1364925	c.513C>G	synonymous_variant	0.52	pyrazinamide
sigE	1364928	c.516C>T	synonymous_variant	0.49	pyrazinamide
sigE	1364952	c.540A>C	synonymous_variant	0.3	pyrazinamide
embR	1416301	c.1047C>A	synonymous_variant	0.39	ethambutol
embR	1416310	c.1038G>C	synonymous_variant	0.48	ethambutol
embR	1416313	c.1035A>G	synonymous_variant	0.47	ethambutol
embR	1416316	c.1032C>G	synonymous_variant	0.49	ethambutol
embR	1416330	p.Val340Ile	missense_variant	0.54	ethambutol
embR	1416332	p.Tyr339Phe	missense_variant	0.54	ethambutol
embR	1416335	p.Asn338Ser	missense_variant	0.56	ethambutol
embR	1416343	c.1005G>C	synonymous_variant	0.62	ethambutol
embR	1416364	c.984C>T	synonymous_variant	0.63	ethambutol
embR	1416386	p.Asp321Ala	missense_variant	0.43	ethambutol
embR	1416388	c.960A>G	synonymous_variant	0.38	ethambutol
embR	1416393	p.Val319Ile	missense_variant	0.38	ethambutol	Uncertain significance
atpE	1460807	c.-238C>T	upstream_gene_variant	0.74	bedaquiline
atpE	1460816	c.-229T>C	upstream_gene_variant	0.73	bedaquiline
atpE	1460828	c.-217C>T	upstream_gene_variant	0.69	bedaquiline
atpE	1460831	c.-214T>C	upstream_gene_variant	0.66	bedaquiline
atpE	1460840	c.-205A>G	upstream_gene_variant	0.69	bedaquiline
atpE	1460855	c.-190T>C	upstream_gene_variant	0.71	bedaquiline
atpE	1460858	c.-187C>G	upstream_gene_variant	0.74	bedaquiline
atpE	1460882	c.-163T>C	upstream_gene_variant	0.7	bedaquiline
atpE	1460894	c.-151A>G	upstream_gene_variant	0.54	bedaquiline
atpE	1460895	c.-150_-148delGCAinsTC	upstream_gene_variant	0.52	bedaquiline
atpE	1460900	c.-145T>C	upstream_gene_variant	0.54	bedaquiline
atpE	1460904	c.-141C>T	upstream_gene_variant	0.56	bedaquiline
atpE	1460918	c.-127A>G	upstream_gene_variant	0.57	bedaquiline
atpE	1460927	c.-118C>G	upstream_gene_variant	0.4	bedaquiline
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471923	n.78T>C	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471925	n.80T>C	non_coding_transcript_exon_variant	0.74	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471932	n.87A>G	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	0.59	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472030	n.185G>T	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472031	n.186G>T	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472033	n.188A>G	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472034	n.189T>C	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472040	n.195T>C	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	0.72	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	0.78	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	0.74	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472489	n.644A>G	non_coding_transcript_exon_variant	0.6	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472686	n.841G>A	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472847	n.1002G>C	non_coding_transcript_exon_variant	0.55	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472848	n.1003T>G	non_coding_transcript_exon_variant	0.55	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472849	n.1004C>G	non_coding_transcript_exon_variant	0.55	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472850	n.1005T>C	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472857	n.1012A>G	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472858	n.1013G>T	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472859	n.1014G>C	non_coding_transcript_exon_variant	0.52	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472860	n.1015C>G	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472969	n.1124A>G	non_coding_transcript_exon_variant	0.77	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472970	n.1125C>G	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472977	n.1132G>C	non_coding_transcript_exon_variant	0.72	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTT	non_coding_transcript_exon_variant	0.65	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473288	n.1443C>T	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473291	n.1446G>T	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1473417	n.-241C>T	upstream_gene_variant	0.65	capreomycin
rrl	1473417	n.-241C>T	upstream_gene_variant	0.65	linezolid
rrl	1473420	n.-238A>G	upstream_gene_variant	0.65	capreomycin
rrl	1473420	n.-238A>G	upstream_gene_variant	0.65	linezolid
rrl	1473421	n.-237G>A	upstream_gene_variant	0.67	capreomycin
rrl	1473421	n.-237G>A	upstream_gene_variant	0.67	linezolid
rrl	1473437	n.-221T>C	upstream_gene_variant	0.52	capreomycin
rrl	1473437	n.-221T>C	upstream_gene_variant	0.52	linezolid
rrl	1473659	n.2T>C	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1473659	n.2T>C	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1473676	n.19G>A	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1473676	n.19G>A	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1473797	n.140G>T	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1473797	n.140G>T	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1473831	n.174G>A	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1473831	n.174G>A	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1473876	n.219G>A	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1473876	n.219G>A	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1473887	n.230T>A	non_coding_transcript_exon_variant	0.81	capreomycin
rrl	1473887	n.230T>A	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1473888	n.231T>A	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1473888	n.231T>A	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1473899	n.242A>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1473899	n.242A>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1473918	n.261C>T	non_coding_transcript_exon_variant	0.73	capreomycin
rrl	1473918	n.261C>T	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1473924	n.267_268insT	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1473924	n.267_268insT	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1473981	n.324delGinsAT	non_coding_transcript_exon_variant	0.73	capreomycin
rrl	1473981	n.324delGinsAT	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1473994	n.337C>T	non_coding_transcript_exon_variant	0.77	capreomycin
rrl	1473994	n.337C>T	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.77	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.84	linezolid	Not assoc w R
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1474011	n.354G>A	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1474011	n.354G>A	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1474018	n.361G>A	non_coding_transcript_exon_variant	0.81	capreomycin
rrl	1474018	n.361G>A	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1474030	n.373G>A	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1474030	n.373G>A	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1474061	n.404T>C	non_coding_transcript_exon_variant	0.73	capreomycin
rrl	1474061	n.404T>C	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1474089	n.432C>T	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1474089	n.432C>T	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1474093	n.436G>A	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1474093	n.436G>A	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1474100	n.443C>T	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1474100	n.443C>T	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474110	n.453A>C	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474110	n.453A>C	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.63	capreomycin
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1474130	n.473C>T	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1474130	n.473C>T	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474447	n.790G>A	non_coding_transcript_exon_variant	0.4	capreomycin
rrl	1474447	n.790G>A	non_coding_transcript_exon_variant	0.4	linezolid
rrl	1474627	n.970G>A	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474627	n.970G>A	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474717	n.1060A>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474717	n.1060A>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474753	n.1096A>G	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1474753	n.1096A>G	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.74	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.74	linezolid	Uncertain significance
rrl	1474783	n.1126G>A	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1474783	n.1126G>A	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475013	n.1356G>A	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1475013	n.1356G>A	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1475018	n.1361G>A	non_coding_transcript_exon_variant	0.54	capreomycin
rrl	1475018	n.1361G>A	non_coding_transcript_exon_variant	0.54	linezolid
rrl	1475027	n.1370G>T	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1475027	n.1370G>T	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1475028	n.1371G>T	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1475028	n.1371G>T	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1475401	n.1745delC	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1475401	n.1745delC	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1475404	n.1747A>G	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1475404	n.1747A>G	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1475405	n.1748A>T	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1475405	n.1748A>T	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1475453	n.1796T>A	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1475453	n.1796T>A	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475480	n.1823A>G	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1475480	n.1823A>G	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1475487	n.1830C>T	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1475487	n.1830C>T	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1475604	n.1947A>C	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1475604	n.1947A>C	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1475605	n.1948A>T	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1475605	n.1948A>T	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1475617	n.1960C>G	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1475617	n.1960C>G	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1475625	n.1968G>C	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1475625	n.1968G>C	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1475637	n.1980T>A	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1475637	n.1980T>A	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1475659	n.2002G>A	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1475659	n.2002G>A	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1475760	n.2103C>T	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1475760	n.2103C>T	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.77	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.75	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1475999	n.2342G>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1475999	n.2342G>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1476032	n.2375C>T	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1476032	n.2375C>T	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1476034	n.2377C>G	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1476034	n.2377C>G	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1476045	n.2388G>C	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1476045	n.2388G>C	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1476047	n.2390G>A	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1476047	n.2390G>A	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476077	n.2420T>C	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1476077	n.2420T>C	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1476095	n.2438C>T	non_coding_transcript_exon_variant	0.69	capreomycin
rrl	1476095	n.2438C>T	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1476580	n.2923G>A	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1476580	n.2923G>A	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.86	linezolid
rrl	1476619	n.2962C>T	non_coding_transcript_exon_variant	0.85	capreomycin	Not assoc w R
rrl	1476619	n.2962C>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1476723	n.3066T>A	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1476723	n.3066T>A	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1476725	n.3068C>T	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1476725	n.3068C>T	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1476750	n.3093T>C	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1476750	n.3093T>C	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1476755	n.3098G>A	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1476755	n.3098G>A	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1476759	n.3102T>C	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1476759	n.3102T>C	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1476770	n.3113T>C	non_coding_transcript_exon_variant	0.42	capreomycin
rrl	1476770	n.3113T>C	non_coding_transcript_exon_variant	0.42	linezolid
rrl	1476771	n.3114G>A	non_coding_transcript_exon_variant	0.42	capreomycin
rrl	1476771	n.3114G>A	non_coding_transcript_exon_variant	0.42	linezolid
inhA	1673475	c.-727A>C	upstream_gene_variant	0.47	ethionamide
inhA	1673475	c.-727A>C	upstream_gene_variant	0.47	isoniazid
inhA	1673499	c.-703T>C	upstream_gene_variant	0.69	ethionamide
inhA	1673499	c.-703T>C	upstream_gene_variant	0.69	isoniazid	Uncertain significance
inhA	1673505	c.-697A>T	upstream_gene_variant	0.7	ethionamide
inhA	1673505	c.-697A>T	upstream_gene_variant	0.7	isoniazid
inhA	1673517	c.-685G>C	upstream_gene_variant	0.69	ethionamide
inhA	1673517	c.-685G>C	upstream_gene_variant	0.69	isoniazid
inhA	1673524	c.-678C>T	upstream_gene_variant	0.73	ethionamide
inhA	1673524	c.-678C>T	upstream_gene_variant	0.73	isoniazid
inhA	1673535	c.-667A>G	upstream_gene_variant	0.76	ethionamide
inhA	1673535	c.-667A>G	upstream_gene_variant	0.76	isoniazid
inhA	1673547	c.-655T>C	upstream_gene_variant	0.75	ethionamide
inhA	1673547	c.-655T>C	upstream_gene_variant	0.75	isoniazid
inhA	1673856	c.-346T>G	upstream_gene_variant	0.48	ethionamide
inhA	1673856	c.-346T>G	upstream_gene_variant	0.48	isoniazid
inhA	1673865	c.-337C>G	upstream_gene_variant	0.57	ethionamide
inhA	1673865	c.-337C>G	upstream_gene_variant	0.57	isoniazid
fabG1	1673870	p.Ser144Met	missense_variant	0.57	ethionamide
fabG1	1673870	p.Ser144Met	missense_variant	0.57	isoniazid
inhA	1673877	c.-325C>T	upstream_gene_variant	0.67	ethionamide
inhA	1673877	c.-325C>T	upstream_gene_variant	0.67	isoniazid
inhA	1673901	c.-301A>C	upstream_gene_variant	0.71	ethionamide
inhA	1673901	c.-301A>C	upstream_gene_variant	0.71	isoniazid
inhA	1673904	c.-298C>G	upstream_gene_variant	0.71	ethionamide
inhA	1673904	c.-298C>G	upstream_gene_variant	0.71	isoniazid
fabG1	1673905	p.Ser156Ala	missense_variant	0.71	ethionamide
fabG1	1673905	p.Ser156Ala	missense_variant	0.71	isoniazid
inhA	1673916	c.-286A>C	upstream_gene_variant	0.69	ethionamide
inhA	1673916	c.-286A>C	upstream_gene_variant	0.69	isoniazid
fabG1	1673917	p.Val160Leu	missense_variant	0.69	ethionamide
fabG1	1673917	p.Val160Leu	missense_variant	0.69	isoniazid
inhA	1673922	c.-280T>C	upstream_gene_variant	0.69	ethionamide
inhA	1673922	c.-280T>C	upstream_gene_variant	0.69	isoniazid
inhA	1673925	c.-277C>G	upstream_gene_variant	0.69	ethionamide
inhA	1673925	c.-277C>G	upstream_gene_variant	0.69	isoniazid
fabG1	1673941	p.Ala168Ser	missense_variant	0.6	ethionamide
fabG1	1673941	p.Ala168Ser	missense_variant	0.6	isoniazid
inhA	1673946	c.-256C>G	upstream_gene_variant	0.56	ethionamide
inhA	1673946	c.-256C>G	upstream_gene_variant	0.56	isoniazid
inhA	1674452	p.Ala84Glu	missense_variant	0.24	ethionamide
inhA	1674452	p.Ala84Glu	missense_variant	0.24	isoniazid
inhA	1674463	c.262_264delCTCinsAT	frameshift_variant&missense_variant	0.38	ethionamide
inhA	1674463	c.262_264delCTCinsAT	frameshift_variant&missense_variant	0.38	isoniazid
inhA	1674471	c.270G>C	synonymous_variant	0.34	ethionamide
inhA	1674471	c.270G>C	synonymous_variant	0.34	isoniazid
inhA	1674480	c.279T>C	synonymous_variant	0.4	ethionamide
inhA	1674480	c.279T>C	synonymous_variant	0.4	isoniazid
inhA	1674489	c.288G>T	synonymous_variant	0.4	ethionamide
inhA	1674489	c.288G>T	synonymous_variant	0.4	isoniazid
inhA	1674507	c.306G>A	synonymous_variant	0.59	ethionamide
inhA	1674507	c.306G>A	synonymous_variant	0.59	isoniazid
inhA	1674534	c.333G>C	synonymous_variant	0.62	ethionamide
inhA	1674534	c.333G>C	synonymous_variant	0.62	isoniazid	Not assoc w R - Interim
inhA	1674537	c.336C>A	synonymous_variant	0.59	ethionamide
inhA	1674537	c.336C>A	synonymous_variant	0.59	isoniazid
inhA	1674540	c.339C>T	synonymous_variant	0.59	ethionamide
inhA	1674540	c.339C>T	synonymous_variant	0.59	isoniazid
inhA	1674542	p.Ala114Glu	missense_variant	0.61	ethionamide
inhA	1674542	p.Ala114Glu	missense_variant	0.61	isoniazid
inhA	1674549	c.348G>C	synonymous_variant	0.63	ethionamide
inhA	1674549	c.348G>C	synonymous_variant	0.63	isoniazid
inhA	1674555	c.354G>A	synonymous_variant	0.68	ethionamide	Not assoc w R - Interim
inhA	1674555	c.354G>A	synonymous_variant	0.68	isoniazid	Not assoc w R - Interim
inhA	1674561	c.360C>T	synonymous_variant	0.7	ethionamide
inhA	1674561	c.360C>T	synonymous_variant	0.7	isoniazid
inhA	1674585	c.384T>C	synonymous_variant	0.71	ethionamide
inhA	1674585	c.384T>C	synonymous_variant	0.71	isoniazid
inhA	1674588	c.387G>A	synonymous_variant	0.68	ethionamide
inhA	1674588	c.387G>A	synonymous_variant	0.68	isoniazid
inhA	1674589	p.Met130Leu	missense_variant	0.68	ethionamide
inhA	1674589	p.Met130Leu	missense_variant	0.68	isoniazid
inhA	1674601	p.Leu134Val	missense_variant	0.64	ethionamide
inhA	1674601	p.Leu134Val	missense_variant	0.64	isoniazid
inhA	1674618	c.417C>T	synonymous_variant	0.6	ethionamide
inhA	1674618	c.417C>T	synonymous_variant	0.6	isoniazid
inhA	1674619	p.Pro140Ser	missense_variant	0.6	ethionamide
inhA	1674619	p.Pro140Ser	missense_variant	0.6	isoniazid
inhA	1674624	c.423A>T	synonymous_variant	0.62	ethionamide
inhA	1674624	c.423A>T	synonymous_variant	0.62	isoniazid
inhA	1674627	c.426T>C	synonymous_variant	0.65	ethionamide
inhA	1674627	c.426T>C	synonymous_variant	0.65	isoniazid
inhA	1674655	c.454_456delAGCinsTCG	synonymous_variant	0.59	ethionamide
inhA	1674655	c.454_456delAGCinsTCG	synonymous_variant	0.59	isoniazid
inhA	1674669	c.468G>C	synonymous_variant	0.65	ethionamide
inhA	1674669	c.468G>C	synonymous_variant	0.65	isoniazid
inhA	1674687	c.486G>A	synonymous_variant	0.73	ethionamide	Not assoc w R - Interim
inhA	1674687	c.486G>A	synonymous_variant	0.73	isoniazid	Not assoc w R - Interim
inhA	1674690	c.489C>G	synonymous_variant	0.73	ethionamide
inhA	1674690	c.489C>G	synonymous_variant	0.73	isoniazid
inhA	1674696	c.495G>A	synonymous_variant	0.72	ethionamide
inhA	1674696	c.495G>A	synonymous_variant	0.72	isoniazid
inhA	1674703	c.502T>C	synonymous_variant	0.76	ethionamide
inhA	1674703	c.502T>C	synonymous_variant	0.76	isoniazid
inhA	1674717	c.516C>T	synonymous_variant	0.67	ethionamide
inhA	1674717	c.516C>T	synonymous_variant	0.67	isoniazid
inhA	1674718	c.517A>C	synonymous_variant	0.67	ethionamide
inhA	1674718	c.517A>C	synonymous_variant	0.67	isoniazid
inhA	1674729	c.528G>A	synonymous_variant	0.66	ethionamide
inhA	1674729	c.528G>A	synonymous_variant	0.66	isoniazid
inhA	1674792	c.591G>C	synonymous_variant	0.46	ethionamide
inhA	1674792	c.591G>C	synonymous_variant	0.46	isoniazid
inhA	1674801	c.600T>C	synonymous_variant	0.56	ethionamide
inhA	1674801	c.600T>C	synonymous_variant	0.56	isoniazid
inhA	1674820	c.619_621delCTCinsTG	frameshift_variant&missense_variant	0.6	ethionamide
inhA	1674820	c.619_621delCTCinsTG	frameshift_variant&missense_variant	0.6	isoniazid
inhA	1674828	c.627G>A	synonymous_variant	0.64	ethionamide
inhA	1674828	c.627G>A	synonymous_variant	0.64	isoniazid
inhA	1674846	p.Ile215Met	missense_variant	0.72	ethionamide
inhA	1674846	p.Ile215Met	missense_variant	0.72	isoniazid
inhA	1674870	c.669T>C	synonymous_variant	0.8	ethionamide
inhA	1674870	c.669T>C	synonymous_variant	0.8	isoniazid
inhA	1674876	c.675C>G	synonymous_variant	0.79	ethionamide
inhA	1674876	c.675C>G	synonymous_variant	0.79	isoniazid
inhA	1674879	c.678T>C	synonymous_variant	0.78	ethionamide
inhA	1674879	c.678T>C	synonymous_variant	0.78	isoniazid
inhA	1674888	c.687C>T	synonymous_variant	0.8	ethionamide
inhA	1674888	c.687C>T	synonymous_variant	0.8	isoniazid
inhA	1674904	c.703_705delGCGinsCC	frameshift_variant&missense_variant	0.77	ethionamide
inhA	1674904	c.703_705delGCGinsCC	frameshift_variant&missense_variant	0.77	isoniazid
inhA	1674909	c.708G>C	synonymous_variant	0.79	ethionamide
inhA	1674909	c.708G>C	synonymous_variant	0.79	isoniazid
inhA	1674915	c.714C>G	synonymous_variant	0.79	ethionamide
inhA	1674915	c.714C>G	synonymous_variant	0.79	isoniazid
inhA	1674939	c.738G>A	synonymous_variant	0.74	ethionamide	Not assoc w R - Interim
inhA	1674939	c.738G>A	synonymous_variant	0.74	isoniazid	Not assoc w R - Interim
inhA	1674942	c.741T>C	synonymous_variant	0.73	ethionamide
inhA	1674942	c.741T>C	synonymous_variant	0.73	isoniazid
rpsA	1833262	c.-280T>C	upstream_gene_variant	0.49	pyrazinamide
rpsA	1833273	c.-269G>A	upstream_gene_variant	0.55	pyrazinamide
rpsA	1833277	c.-265C>G	upstream_gene_variant	0.57	pyrazinamide
rpsA	1833283	c.-259C>G	upstream_gene_variant	0.58	pyrazinamide
rpsA	1833288	c.-254_-253delTGinsCC	upstream_gene_variant	0.58	pyrazinamide
rpsA	1833304	c.-238C>G	upstream_gene_variant	0.62	pyrazinamide
rpsA	1833310	c.-232T>C	upstream_gene_variant	0.63	pyrazinamide
rpsA	1833319	c.-223C>G	upstream_gene_variant	0.57	pyrazinamide
rpsA	1833340	c.-202G>C	upstream_gene_variant	0.51	pyrazinamide
rpsA	1833343	c.-199G>C	upstream_gene_variant	0.46	pyrazinamide
rpsA	1833352	c.-190C>G	upstream_gene_variant	0.4	pyrazinamide
rpsA	1833356	c.-186_-185delAGinsTC	upstream_gene_variant	0.37	pyrazinamide
rpsA	1833367	c.-175G>C	upstream_gene_variant	0.33	pyrazinamide
rpsA	1833370	c.-172G>C	upstream_gene_variant	0.29	pyrazinamide
rpsA	1833517	c.-24delC	upstream_gene_variant	0.58	pyrazinamide
rpsA	1833532	c.-10A>C	upstream_gene_variant	0.6	pyrazinamide
rpsA	1833568	c.27G>C	synonymous_variant	0.73	pyrazinamide	Not assoc w R - Interim
rpsA	1833589	c.48A>T	synonymous_variant	0.73	pyrazinamide
rpsA	1833595	c.54T>C	synonymous_variant	0.72	pyrazinamide
rpsA	1833613	c.72C>A	synonymous_variant	0.73	pyrazinamide
rpsA	1833619	c.78A>C	synonymous_variant	0.74	pyrazinamide
rpsA	1833661	c.120A>G	synonymous_variant	0.75	pyrazinamide
rpsA	1833667	c.126C>G	synonymous_variant	0.74	pyrazinamide
rpsA	1833703	c.162C>T	synonymous_variant	0.72	pyrazinamide	Not assoc w R - Interim
rpsA	1833724	c.183C>G	synonymous_variant	0.72	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.73	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.75	pyrazinamide
rpsA	1833760	c.219C>T	synonymous_variant	0.78	pyrazinamide	Not assoc w R - Interim
rpsA	1833790	c.249T>C	synonymous_variant	0.83	pyrazinamide
rpsA	1833793	c.252C>T	synonymous_variant	0.82	pyrazinamide
rpsA	1833802	c.261A>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833808	c.267G>C	synonymous_variant	0.84	pyrazinamide
rpsA	1833811	c.270G>T	synonymous_variant	0.82	pyrazinamide
rpsA	1833832	c.291G>A	synonymous_variant	0.79	pyrazinamide
rpsA	1833838	c.297G>C	synonymous_variant	0.75	pyrazinamide
rpsA	1833841	c.300C>G	synonymous_variant	0.75	pyrazinamide
rpsA	1833847	c.306C>G	synonymous_variant	0.77	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	0.77	pyrazinamide
rpsA	1833859	c.318C>T	synonymous_variant	0.79	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.79	pyrazinamide
rpsA	1833895	c.354G>C	synonymous_variant	0.81	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.86	pyrazinamide
rpsA	1833949	c.408T>C	synonymous_variant	0.89	pyrazinamide
rpsA	1833970	c.429G>A	synonymous_variant	0.86	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.87	pyrazinamide
rpsA	1834015	c.474G>C	synonymous_variant	0.84	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	0.83	pyrazinamide
rpsA	1834102	c.561T>C	synonymous_variant	0.7	pyrazinamide
rpsA	1834105	c.564C>T	synonymous_variant	0.69	pyrazinamide
rpsA	1834150	c.609G>C	synonymous_variant	0.62	pyrazinamide
rpsA	1834153	c.612T>C	synonymous_variant	0.59	pyrazinamide
rpsA	1834154	c.613_615delAACinsCG	frameshift_variant&missense_variant	0.58	pyrazinamide	Uncertain significance
rpsA	1834157	c.616T>C	synonymous_variant	0.55	pyrazinamide
rpsA	1834162	c.621A>G	synonymous_variant	0.55	pyrazinamide	Not assoc w R - Interim
rpsA	1834165	c.624A>G	synonymous_variant	0.52	pyrazinamide
rpsA	1834177	c.636A>C	synonymous_variant	0.69	pyrazinamide	Not assoc w R - Interim
rpsA	1834186	c.645C>G	synonymous_variant	0.75	pyrazinamide
rpsA	1834189	c.648G>C	synonymous_variant	0.73	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.76	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.75	pyrazinamide
rpsA	1834225	c.684C>G	synonymous_variant	0.75	pyrazinamide
rpsA	1834231	c.690T>G	synonymous_variant	0.8	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.84	pyrazinamide
rpsA	1834261	c.720A>G	synonymous_variant	0.83	pyrazinamide	Not assoc w R - Interim
rpsA	1834264	c.723G>C	synonymous_variant	0.83	pyrazinamide
rpsA	1834279	c.738C>T	synonymous_variant	0.86	pyrazinamide	Not assoc w R - Interim
rpsA	1834297	c.756C>T	synonymous_variant	0.84	pyrazinamide
rpsA	1834303	c.762T>G	synonymous_variant	0.85	pyrazinamide
rpsA	1834336	c.795C>G	synonymous_variant	0.88	pyrazinamide
rpsA	1834348	c.807T>C	synonymous_variant	0.86	pyrazinamide	Not assoc w R - Interim
rpsA	1834366	c.825A>G	synonymous_variant	0.85	pyrazinamide	Not assoc w R - Interim
rpsA	1834375	c.834G>A	synonymous_variant	0.87	pyrazinamide
rpsA	1834396	c.855G>T	synonymous_variant	0.89	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.9	pyrazinamide
rpsA	1834423	c.882G>T	synonymous_variant	0.89	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.86	pyrazinamide
rpsA	1834456	c.915T>G	synonymous_variant	0.87	pyrazinamide
rpsA	1834465	c.924T>C	synonymous_variant	0.87	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.85	pyrazinamide
rpsA	1834477	c.936C>T	synonymous_variant	0.86	pyrazinamide	Not assoc w R - Interim
rpsA	1834489	c.948T>C	synonymous_variant	0.84	pyrazinamide
rpsA	1834510	c.969C>T	synonymous_variant	0.85	pyrazinamide	Not assoc w R - Interim
rpsA	1834519	c.978G>C	synonymous_variant	0.85	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	0.82	pyrazinamide
rpsA	1834555	c.1014T>G	synonymous_variant	0.83	pyrazinamide
rpsA	1834603	c.1062G>A	synonymous_variant	0.84	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	0.84	pyrazinamide
rpsA	1834612	c.1071G>A	synonymous_variant	0.84	pyrazinamide	Not assoc w R - Interim
rpsA	1834633	c.1092A>G	synonymous_variant	0.86	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	0.85	pyrazinamide
rpsA	1834654	c.1113G>A	synonymous_variant	0.88	pyrazinamide
rpsA	1834690	c.1149T>C	synonymous_variant	0.82	pyrazinamide
rpsA	1834699	p.Glu386Asp	missense_variant	0.84	pyrazinamide
rpsA	1834732	c.1191T>C	synonymous_variant	0.58	pyrazinamide
rpsA	1834789	c.1248T>C	synonymous_variant	0.44	pyrazinamide
rpsA	1834792	c.1251G>C	synonymous_variant	0.47	pyrazinamide
rpsA	1834813	c.1272G>A	synonymous_variant	0.64	pyrazinamide	Not assoc w R - Interim
rpsA	1834852	c.1311C>G	synonymous_variant	0.72	pyrazinamide
rpsA	1834858	c.1317G>A	synonymous_variant	0.71	pyrazinamide	Not assoc w R - Interim
rpsA	1834864	c.1323T>C	synonymous_variant	0.59	pyrazinamide
rpsA	1834869	p.Arg443His	missense_variant	0.46	pyrazinamide
tsnR	1853390	c.-216G>C	upstream_gene_variant	0.23	linezolid
tsnR	1853393	c.-213C>T	upstream_gene_variant	0.25	linezolid
tsnR	1853394	c.-212_-211delCTinsGC	upstream_gene_variant	0.24	linezolid
tsnR	1853420	c.-186T>G	upstream_gene_variant	0.28	linezolid
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
tlyA	1918377	c.438T>G	synonymous_variant	0.4	capreomycin
tlyA	1918380	c.441C>T	synonymous_variant	0.44	capreomycin
tlyA	1918395	c.456G>C	synonymous_variant	0.36	capreomycin
tlyA	1918410	c.471C>T	synonymous_variant	0.4	capreomycin	Not assoc w R - Interim
tlyA	1918442	p.Val168Ala	missense_variant	0.48	capreomycin
tlyA	1918446	c.507A>T	synonymous_variant	0.44	capreomycin
tlyA	1918452	c.513T>G	synonymous_variant	0.45	capreomycin
tlyA	1918454	p.Ser172Trp	missense_variant	0.42	capreomycin
tlyA	1918457	p.Arg173Pro	missense_variant	0.41	capreomycin
tlyA	1918460	p.Asp174Gly	missense_variant	0.41	capreomycin
tlyA	1918464	c.525C>G	synonymous_variant	0.41	capreomycin
tlyA	1918476	c.537A>C	synonymous_variant	0.48	capreomycin
tlyA	1918477	p.Leu180Met	missense_variant	0.48	capreomycin
tlyA	1918497	c.558G>A	synonymous_variant	0.32	capreomycin	Not assoc w R - Interim
bacA	2064891	c.-163C>G	upstream_gene_variant	0.23	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064900	c.-172G>A	upstream_gene_variant	0.3	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064912	c.-184A>G	upstream_gene_variant	0.32	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064933	c.-205A>C	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064934	c.-208_-206delCTCinsTG	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064948	c.-220G>C	upstream_gene_variant	0.44	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064951	c.-223C>G	upstream_gene_variant	0.46	streptomycin
					kanamycin
					capreomycin
					amikacin
ndh	2101804	c.1239T>G	synonymous_variant	0.4	ethionamide
					delamanid
					isoniazid
ndh	2101813	c.1230G>A	synonymous_variant	0.46	ethionamide
					delamanid
					isoniazid
ndh	2101825	c.1218G>A	synonymous_variant	0.52	ethionamide
					delamanid
					isoniazid
ndh	2101837	p.Ala402Val	missense_variant	0.55	ethionamide	Uncertain significance
					delamanid
					isoniazid	Uncertain significance
ndh	2101858	p.Ile395Met	missense_variant	0.53	ethionamide
					delamanid
					isoniazid
ndh	2101873	c.1170T>C	synonymous_variant	0.48	ethionamide
					delamanid
					isoniazid
ndh	2101879	c.1164C>T	synonymous_variant	0.45	ethionamide	Not assoc w R - Interim
					delamanid
					isoniazid	Not assoc w R - Interim
ndh	2101890	p.Val385Leu	missense_variant	0.34	ethionamide
					delamanid
					isoniazid
ndh	2101894	c.1149T>C	synonymous_variant	0.32	ethionamide
					delamanid
					isoniazid
ndh	2101897	c.1146C>T	synonymous_variant	0.25	ethionamide
					delamanid
					isoniazid
ndh	2102632	c.411C>T	synonymous_variant	0.54	ethionamide	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
ndh	2102638	c.405A>G	synonymous_variant	0.57	ethionamide
					delamanid
					isoniazid
ndh	2102644	c.399A>G	synonymous_variant	0.62	ethionamide
					delamanid
					isoniazid
ndh	2102671	c.372T>G	synonymous_variant	0.63	ethionamide
					delamanid
					isoniazid
ndh	2102674	c.369G>A	synonymous_variant	0.59	ethionamide
					delamanid
					isoniazid
ndh	2102677	c.366C>G	synonymous_variant	0.58	ethionamide
					delamanid
					isoniazid
ndh	2102683	c.360T>C	synonymous_variant	0.6	ethionamide
					delamanid
					isoniazid
ndh	2102686	c.357G>C	synonymous_variant	0.6	ethionamide
					delamanid
					isoniazid
ndh	2102700	c.343C>T	synonymous_variant	0.53	ethionamide
					delamanid
					isoniazid
ndh	2102929	c.114T>C	synonymous_variant	0.36	ethionamide
					delamanid
					isoniazid
ndh	2102938	p.Arg35His	missense_variant	0.38	ethionamide
					delamanid
					isoniazid
ndh	2102959	c.84C>T	synonymous_variant	0.25	ethionamide
					delamanid
					isoniazid
ndh	2102962	c.81A>C	synonymous_variant	0.23	ethionamide
					delamanid
					isoniazid
katG	2155026	c.1086C>G	synonymous_variant	0.5	isoniazid
katG	2155047	c.1065C>G	synonymous_variant	0.56	isoniazid
katG	2155054	p.Tyr353Phe	missense_variant	0.48	isoniazid
katG	2155056	c.1056A>G	synonymous_variant	0.48	isoniazid
katG	2155062	c.1050T>C	synonymous_variant	0.5	isoniazid
katG	2155068	c.1044T>G	synonymous_variant	0.58	isoniazid
katG	2155071	c.1041T>G	synonymous_variant	0.58	isoniazid
katG	2155080	c.1032G>C	synonymous_variant	0.57	isoniazid
katG	2155083	c.1029G>C	synonymous_variant	0.53	isoniazid
katG	2155086	c.1026G>A	synonymous_variant	0.55	isoniazid
katG	2155119	c.993T>C	synonymous_variant	0.48	isoniazid
katG	2155131	c.981A>G	synonymous_variant	0.52	isoniazid	Not assoc w R - Interim
katG	2155134	c.978G>C	synonymous_variant	0.56	isoniazid
katG	2155144	p.Asn323Pro	missense_variant	0.54	isoniazid
katG	2155152	c.960A>G	synonymous_variant	0.48	isoniazid
katG	2155155	c.957C>G	synonymous_variant	0.46	isoniazid
katG	2155185	c.927T>C	synonymous_variant	0.36	isoniazid
katG	2155614	c.498T>G	synonymous_variant	0.61	isoniazid
katG	2155626	c.486G>C	synonymous_variant	0.62	isoniazid
katG	2155632	c.480A>G	synonymous_variant	0.59	isoniazid
katG	2155637	p.Leu159Ile	missense_variant	0.61	isoniazid
katG	2155641	p.Lys157Asn	missense_variant	0.61	isoniazid	Uncertain significance
katG	2155651	p.Lys154Arg	missense_variant	0.64	isoniazid
katG	2155656	c.456G>A	synonymous_variant	0.7	isoniazid
katG	2155661	p.Val151Ile	missense_variant	0.67	isoniazid
katG	2155680	c.432G>C	synonymous_variant	0.52	isoniazid
katG	2155691	c.421T>C	synonymous_variant	0.56	isoniazid
katG	2155695	c.417C>G	synonymous_variant	0.56	isoniazid
katG	2155716	c.396T>C	synonymous_variant	0.5	isoniazid
katG	2155728	c.384G>C	synonymous_variant	0.44	isoniazid
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
kasA	2517941	c.-174C>G	upstream_gene_variant	0.73	isoniazid
kasA	2517950	c.-165C>G	upstream_gene_variant	0.78	isoniazid
kasA	2517962	c.-153C>G	upstream_gene_variant	0.74	isoniazid
kasA	2517974	c.-141T>C	upstream_gene_variant	0.7	isoniazid
kasA	2517983	c.-132T>C	upstream_gene_variant	0.69	isoniazid
kasA	2517989	c.-126T>G	upstream_gene_variant	0.66	isoniazid
kasA	2517993	c.-122G>T	upstream_gene_variant	0.69	isoniazid
kasA	2518019	c.-96A>G	upstream_gene_variant	0.62	isoniazid
kasA	2518025	c.-90G>C	upstream_gene_variant	0.56	isoniazid
kasA	2518031	c.-84G>T	upstream_gene_variant	0.47	isoniazid
kasA	2518034	c.-81T>C	upstream_gene_variant	0.44	isoniazid
kasA	2518040	c.-75G>T	upstream_gene_variant	0.43	isoniazid
kasA	2518041	c.-74T>C	upstream_gene_variant	0.43	isoniazid
kasA	2518049	c.-66G>C	upstream_gene_variant	0.39	isoniazid
kasA	2518053	c.-62_-60delATTinsCG	upstream_gene_variant	0.37	isoniazid
kasA	2518132	c.18C>T	synonymous_variant	0.41	isoniazid
kasA	2518138	c.24T>C	synonymous_variant	0.5	isoniazid
kasA	2518146	p.Phe11Tyr	missense_variant	0.57	isoniazid
kasA	2518152	p.Ser13Asn	missense_variant	0.58	isoniazid
kasA	2518162	c.48G>A	synonymous_variant	0.69	isoniazid
kasA	2518169	p.Val19Leu	missense_variant	0.67	isoniazid
kasA	2518172	c.58_60delACAinsGG	frameshift_variant&missense_variant	0.68	isoniazid
kasA	2518190	p.Ser26Ala	missense_variant	0.75	isoniazid
kasA	2518199	p.Ile29Val	missense_variant	0.75	isoniazid
kasA	2518219	c.105T>C	synonymous_variant	0.68	isoniazid
kasA	2518220	c.106C>T	synonymous_variant	0.68	isoniazid
kasA	2518245	p.His44Arg	missense_variant	0.64	isoniazid
kasA	2518248	p.Ala45Val	missense_variant	0.61	isoniazid
kasA	2518261	p.Glu49Asp	missense_variant	0.65	isoniazid
kasA	2518273	c.159G>A	synonymous_variant	0.52	isoniazid
kasA	2518279	p.Asp55Glu	missense_variant	0.49	isoniazid
kasA	2518282	c.168A>G	synonymous_variant	0.45	isoniazid
kasA	2518283	p.Ala57Pro	missense_variant	0.46	isoniazid
kasA	2518289	p.Lys59Gln	missense_variant	0.54	isoniazid
kasA	2518297	c.183C>T	synonymous_variant	0.62	isoniazid
kasA	2518300	c.186T>A	synonymous_variant	0.6	isoniazid
kasA	2518312	p.Asp66Glu	missense_variant	0.48	isoniazid
kasA	2518316	p.Val68Ile	missense_variant	0.5	isoniazid
kasA	2518321	c.207C>T	synonymous_variant	0.52	isoniazid
kasA	2518323	p.Ser70Asn	missense_variant	0.5	isoniazid
kasA	2518336	c.222A>G	synonymous_variant	0.52	isoniazid
kasA	2518339	c.225C>G	synonymous_variant	0.5	isoniazid
kasA	2518342	c.228C>T	synonymous_variant	0.42	isoniazid
kasA	2518343	p.Met77Leu	missense_variant	0.42	isoniazid
kasA	2518351	c.237C>G	synonymous_variant	0.38	isoniazid
kasA	2518363	c.249C>T	synonymous_variant	0.32	isoniazid
kasA	2518480	c.366T>C	synonymous_variant	0.28	isoniazid
kasA	2518492	c.378C>T	synonymous_variant	0.47	isoniazid
kasA	2518504	c.390T>C	synonymous_variant	0.48	isoniazid
kasA	2518506	p.Ala131Glu	missense_variant	0.48	isoniazid
kasA	2518519	c.405G>C	synonymous_variant	0.45	isoniazid
kasA	2518528	c.414C>G	synonymous_variant	0.47	isoniazid
kasA	2518534	c.420G>C	synonymous_variant	0.46	isoniazid
kasA	2518561	c.447T>C	synonymous_variant	0.61	isoniazid
kasA	2518567	c.453G>C	synonymous_variant	0.52	isoniazid
kasA	2518570	c.456G>C	synonymous_variant	0.49	isoniazid
kasA	2518573	c.459G>C	synonymous_variant	0.44	isoniazid
kasA	2518574	p.Ile154Val	missense_variant	0.44	isoniazid
kasA	2518582	c.468G>C	synonymous_variant	0.46	isoniazid
kasA	2518583	c.469_471delCAGinsGA	frameshift_variant&missense_variant	0.46	isoniazid
kasA	2518594	c.480C>T	synonymous_variant	0.55	isoniazid
kasA	2518597	c.483C>G	synonymous_variant	0.57	isoniazid
kasA	2518606	c.492G>C	synonymous_variant	0.63	isoniazid
kasA	2518609	p.Met165Ile	missense_variant	0.64	isoniazid
kasA	2518636	c.522C>A	synonymous_variant	0.47	isoniazid
kasA	2518639	c.525G>C	synonymous_variant	0.47	isoniazid
kasA	2518642	c.528A>G	synonymous_variant	0.48	isoniazid
kasA	2518645	c.531G>C	synonymous_variant	0.48	isoniazid
kasA	2518651	c.537C>G	synonymous_variant	0.5	isoniazid
kasA	2518657	c.543G>C	synonymous_variant	0.52	isoniazid
kasA	2518663	c.549T>C	synonymous_variant	0.48	isoniazid
kasA	2518672	c.558G>C	synonymous_variant	0.43	isoniazid
kasA	2518693	c.579C>G	synonymous_variant	0.52	isoniazid
kasA	2518702	c.588C>T	synonymous_variant	0.55	isoniazid
kasA	2518711	c.597A>G	synonymous_variant	0.59	isoniazid
kasA	2518714	c.600A>C	synonymous_variant	0.58	isoniazid
kasA	2518717	c.603C>G	synonymous_variant	0.63	isoniazid
kasA	2518723	c.609G>A	synonymous_variant	0.7	isoniazid
kasA	2518735	c.621C>T	synonymous_variant	0.75	isoniazid
kasA	2518747	c.633C>G	synonymous_variant	0.77	isoniazid
kasA	2518768	c.654C>G	synonymous_variant	0.78	isoniazid
kasA	2518783	c.669T>C	synonymous_variant	0.76	isoniazid
kasA	2518789