TB-Profiler result

Run: SRR18549032

Summary

Run ID: SRR18549032

Sample name:

Date: 2024-04-14T19:47:01.580937

Number of reads: 3843122

Percentage reads mapped: 48.4

Median coverage: 91.0

Strain: lineage2.2.1.2;lineage7

Spoligotype:

Drug-resistance: HR-TB


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.93
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
La1.7.1 M.bovis None 0.15
lineage7 Lineage 7 None 0.1
lineage2.2.1.2 East-Asian (Beijing) RD105;RD207;RD181;RD142 0.89
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ofloxacin
levofloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.2265_2266delTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2275_2280delCCCGGGinsGGCCCGGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2344_2346delTCGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2371_2373delCTTinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6738 p.Thr500Asn missense_variant 0.43 moxifloxacin Uncertain significance Mutation from literature
levofloxacin Uncertain significance Mutation from literature
fbiC 1305193 c.2265_2266delTG frameshift_variant 0.33 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305205 c.2275_2280delCCCGGGinsGGCCCGGC frameshift_variant&missense_variant 0.35 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305274 c.2344_2346delTCGinsCC frameshift_variant&missense_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305301 c.2371_2373delCTTinsTG frameshift_variant&missense_variant 0.2 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.26 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155693 p.Ser140Asn missense_variant 1.0 isoniazid Uncertain significance Mutation from literature
embB 4247580 p.Ala356Val missense_variant 0.35 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6265 c.1026C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6316 c.-986G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6324 c.1085_1086insGTCC frameshift_variant 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrB 6327 c.1090_1093delGAAC frameshift_variant 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrA 6343 c.-959G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6385 c.-917G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>A upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6721 c.1482C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6724 c.-578G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6763 c.1524G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6775 c.-527G>T upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Ser missense_variant 0.34 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.3 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 7047 p.Lys603Met missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7335 c.34_36delCTCinsGG frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7349 c.48A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7367 p.Gln22His missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7394 c.93T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7454 c.153G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7490 c.189C>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7514 c.213C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7671 p.Pro124Ala missense_variant 0.54 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCT frameshift_variant&missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7727 c.426G>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 7745 c.444G>A synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7758 c.457_459delATCinsGT frameshift_variant&missense_variant 0.63 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8249 p.Ile316Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8366 c.1065G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8798 c.1497C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8801 c.1500G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8825 c.1524G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9063 p.Ser588Leu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.23 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9144 p.Arg615Lys missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9147 p.Gly616Ser missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9174 c.1873C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9335 c.2034G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9452 c.2151G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
fgd1 491259 c.477T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491277 c.495G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491280 c.498C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491284 p.Gly168Ser missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491307 c.525C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491328 c.546C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491334 c.552C>T synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491337 c.555C>G synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491345 p.Ala188Val missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491364 c.582T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491397 c.615G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491502 p.Glu240Asp missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491503 c.721C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491523 c.741G>T synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491526 c.744T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491541 c.759G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491546 p.Thr255Ser missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_782delAGinsTC synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491592 c.810G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491607 c.825G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.34 ethionamide
isoniazid Not assoc w R - Interim
mshA 575705 c.358T>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575714 p.Tyr123Asn missense_variant 0.37 ethionamide
isoniazid
mshA 575728 c.381C>T synonymous_variant 0.43 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.45 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.47 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.6 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.59 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.6 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.59 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.59 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.6 ethionamide
isoniazid Not assoc w R - Interim
mshA 575837 c.490C>T synonymous_variant 0.53 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575841 c.494_495insT frameshift_variant 0.51 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575844 c.498delC frameshift_variant 0.49 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575848 c.501C>T synonymous_variant 0.5 ethionamide
isoniazid
mshA 575851 c.504C>G synonymous_variant 0.52 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.53 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.48 ethionamide
isoniazid
mshA 575892 p.Ala182Gly missense_variant 0.43 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.65 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.33 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.32 ethionamide
isoniazid
mshA 575923 c.577_578delGG frameshift_variant 0.3 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575929 c.582_583insCG frameshift_variant 0.3 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575944 c.597T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575953 c.606G>T synonymous_variant 0.23 ethionamide
isoniazid
ccsA 620337 c.447C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620343 c.453G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620366 p.Asn159Thr missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620379 c.489G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620409 c.519C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.23 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620431 p.Leu181Ile missense_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620436 c.546T>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620547 c.657C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620556 c.666C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620559 c.669A>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620565 c.675G>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620571 c.681A>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620589 c.699G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>T synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620634 c.744C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620643 c.753C>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734373 c.120G>C synonymous_variant 0.2 rifampicin
nusG 734383 c.130_131delAGinsTC synonymous_variant 0.23 rifampicin
nusG 734391 c.138C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.32 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.4 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.4 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.47 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.49 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.54 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.56 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.58 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>T synonymous_variant 0.58 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.44 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.41 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>T synonymous_variant 0.33 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.23 rifampicin
nusG 734607 c.354C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734853 c.600A>G synonymous_variant 0.19 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.19 rifampicin
nusG 734905 c.652C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734922 c.669C>T synonymous_variant 0.17 rifampicin
rpoB 760046 c.240G>T synonymous_variant 0.2 rifampicin
rpoB 760055 c.249G>T synonymous_variant 0.23 rifampicin
rpoB 760059 c.253_255delTACinsGA frameshift_variant&missense_variant 0.27 rifampicin
rpoB 760070 c.264T>C synonymous_variant 0.37 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760118 c.312T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>G synonymous_variant 0.52 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760139 c.333A>T synonymous_variant 0.54 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.54 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.53 rifampicin
rpoB 760155 p.Lys117Arg missense_variant 0.52 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.56 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.55 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.52 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>G synonymous_variant 0.55 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.5 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.49 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760354 p.Glu183Ala missense_variant 0.36 rifampicin
rpoB 760357 p.Thr184Asn missense_variant 0.37 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.24 rifampicin
rpoB 760394 c.588C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760407 p.Ser201Gly missense_variant 0.2 rifampicin Uncertain significance
rpoB 760494 c.688_690delGTGinsAC frameshift_variant&missense_variant 0.25 rifampicin
rpoB 760514 c.708C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760521 c.715_716delAGinsTC synonymous_variant 0.33 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Arg missense_variant 0.35 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.44 rifampicin Uncertain significance
rpoB 760585 p.Asn260Ser missense_variant 0.44 rifampicin
rpoB 760587 p.Thr261Ala missense_variant 0.45 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.44 rifampicin
rpoB 760593 p.Gly263Ser missense_variant 0.44 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.47 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.41 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760658 c.852G>A synonymous_variant 0.36 rifampicin
rpoB 760661 c.855A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.36 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.18 rifampicin
rpoB 760888 p.Thr361Ile missense_variant 0.16 rifampicin
rpoB 760916 c.1110C>G synonymous_variant 0.31 rifampicin
rpoB 760919 c.1113C>T synonymous_variant 0.3 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.31 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.34 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.35 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.47 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.52 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.59 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.61 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.61 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.61 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.58 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.59 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.6 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.59 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.57 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.54 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.5 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.54 rifampicin
rpoB 761286 c.1480C>T synonymous_variant 0.53 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.37 rifampicin
rpoB 761346 p.Val514Asn missense_variant 0.33 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.33 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761366 c.1560C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761369 p.Glu521Asp missense_variant 0.31 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.31 rifampicin
rpoB 761379 c.1573C>T synonymous_variant 0.31 rifampicin
rpoB 761408 c.1602G>T synonymous_variant 0.31 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.22 rifampicin
rpoB 761465 c.1659G>T synonymous_variant 0.2 rifampicin
rpoB 761474 c.1668C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761477 c.1671C>T synonymous_variant 0.22 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.24 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.38 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.41 rifampicin
rpoB 761508 c.1702_1704delTCTinsGC frameshift_variant&missense_variant 0.42 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.48 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.55 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.61 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.52 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.51 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.47 rifampicin
rpoB 761687 c.1881C>G synonymous_variant 0.47 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.49 rifampicin
rpoB 761702 c.1896C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761711 c.1905C>G synonymous_variant 0.47 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.47 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.35 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsAG frameshift_variant&missense_variant 0.35 rifampicin
rpoB 761728 p.Ser641Thr missense_variant 0.35 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761750 c.1944G>C synonymous_variant 0.38 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.38 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.38 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.33 rifampicin
rpoB 761777 c.1971C>T synonymous_variant 0.33 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.33 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.44 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.45 rifampicin
rpoB 761814 p.Ala670Asn missense_variant 0.45 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.49 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.46 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.45 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.45 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.45 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 0.47 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.5 rifampicin
rpoB 761897 c.2091C>G synonymous_variant 0.5 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.49 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.48 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.49 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.5 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.51 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.53 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAG frameshift_variant&missense_variant 0.59 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.58 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>T synonymous_variant 0.65 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.64 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.63 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.62 rifampicin
rpoB 762134 c.2328C>T synonymous_variant 0.62 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.61 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.61 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.65 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.65 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.63 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.59 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.59 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.6 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.61 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.59 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.58 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.58 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.59 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.57 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.56 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.54 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Ala missense_variant 0.49 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.43 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.42 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.41 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.36 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.34 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.34 rifampicin
rpoC 762557 c.-813G>C upstream_gene_variant 0.33 rifampicin
rpoC 762560 c.-810A>T upstream_gene_variant 0.3 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.31 rifampicin
rpoC 762575 c.-795C>T upstream_gene_variant 0.18 rifampicin
rpoB 762836 c.3030C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762894 c.3088C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762957 c.3151C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.43 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.57 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.59 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.57 rifampicin
rpoB 763085 c.3279C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.59 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.61 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.6 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.55 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.53 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.53 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.52 rifampicin Uncertain significance
rpoB 763227 c.3421C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763262 c.-108C>A upstream_gene_variant 0.44 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.42 rifampicin
rpoB 763283 c.3477T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763304 c.-66A>C upstream_gene_variant 0.21 rifampicin
rpoB 763305 p.Ser1167Cys missense_variant 0.18 rifampicin
rpoC 763310 c.-60C>T upstream_gene_variant 0.18 rifampicin
rpoB 763316 c.3510T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763322 c.-48G>T upstream_gene_variant 0.18 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoC 763396 c.27A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.55 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.59 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.56 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.49 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.49 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.43 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.45 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.42 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.19 rifampicin
rpoC 763981 c.612G>A synonymous_variant 0.19 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.2 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.22 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.22 rifampicin
rpoC 764003 p.Ala212Ser missense_variant 0.22 rifampicin
rpoC 764023 c.654G>C synonymous_variant 0.28 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.28 rifampicin
rpoC 764030 p.Asp221Asn missense_variant 0.29 rifampicin Uncertain significance
rpoC 764039 p.Ser224Asp missense_variant 0.29 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.29 rifampicin
rpoC 764048 p.Thr227Val missense_variant 0.29 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.32 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.29 rifampicin
rpoC 764085 p.Asn239Thr missense_variant 0.28 rifampicin Uncertain significance
rpoC 764087 p.Leu240Val missense_variant 0.31 rifampicin Uncertain significance
rpoC 764098 c.729A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764104 c.735C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764169 p.Asn267Thr missense_variant 0.43 rifampicin
rpoC 764180 p.Asp271His missense_variant 0.44 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Leu missense_variant 0.42 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.42 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Ile missense_variant 0.43 rifampicin
rpoC 764213 p.Arg282Lys missense_variant 0.42 rifampicin Uncertain significance
rpoC 764242 c.873C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>T synonymous_variant 0.48 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.47 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.47 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.48 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.47 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.45 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.47 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.39 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.37 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.4 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.45 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.48 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.49 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.5 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.51 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.64 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.59 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.62 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.62 rifampicin
rpoC 764752 c.1383G>T synonymous_variant 0.62 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.61 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>G synonymous_variant 0.59 rifampicin
rpoC 764875 c.1506C>T synonymous_variant 0.59 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.58 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.52 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.52 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.5 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.46 rifampicin
rpoC 765076 c.1707A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765115 c.1746G>T synonymous_variant 0.28 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765305 c.1936_1938delATCinsGG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 765311 p.Ala648Thr missense_variant 0.21 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765326 c.1957_1959delCACinsGG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 765330 p.Ser654Asn missense_variant 0.23 rifampicin Uncertain significance
rpoC 765339 p.Gln657Arg missense_variant 0.21 rifampicin Uncertain significance
rpoC 765348 p.Asp660Gly missense_variant 0.22 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765358 p.Met663Ile missense_variant 0.28 rifampicin Uncertain significance
rpoC 765383 p.Met672Leu missense_variant 0.38 rifampicin Uncertain significance
rpoC 765404 p.Leu679Thr missense_variant 0.41 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.4 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.54 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765533 c.2164_2166delTACinsCT frameshift_variant&missense_variant 0.57 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.55 rifampicin
rpoC 765553 c.2184C>A synonymous_variant 0.55 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.57 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.62 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.56 rifampicin Uncertain significance
rpoC 765625 c.2256C>T synonymous_variant 0.56 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765635 c.2266_2268delGTCinsCG frameshift_variant&missense_variant 0.54 rifampicin
rpoC 765640 c.2271A>G synonymous_variant 0.53 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 765669 p.His767Arg missense_variant 0.5 rifampicin
rpoC 765673 p.Asp768Glu missense_variant 0.48 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765718 p.Asp783Glu missense_variant 0.48 rifampicin Uncertain significance
rpoC 765721 c.2352G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.48 rifampicin
rpoC 765742 p.Glu791Asp missense_variant 0.46 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.47 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.46 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.49 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.5 rifampicin
rpoC 765790 c.2421C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765793 c.2424C>G synonymous_variant 0.49 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.5 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765823 c.2454C>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.54 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.54 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.55 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.53 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765991 c.2622C>G synonymous_variant 0.38 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766000 c.2631G>T synonymous_variant 0.34 rifampicin
rpoC 766003 c.2634G>C synonymous_variant 0.31 rifampicin
rpoC 766009 c.2640G>T synonymous_variant 0.3 rifampicin
rpoC 766012 c.2643C>T synonymous_variant 0.3 rifampicin
rpoC 766270 c.2901G>C synonymous_variant 0.24 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.23 rifampicin
rpoC 766280 c.2911_2913delAGCinsGA frameshift_variant&missense_variant 0.25 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.29 rifampicin
rpoC 766291 c.2922G>C synonymous_variant 0.31 rifampicin
rpoC 766297 c.2928G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766300 c.2931C>G synonymous_variant 0.33 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>A synonymous_variant 0.35 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.37 rifampicin
rpoC 766351 c.2982C>G synonymous_variant 0.57 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.61 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.62 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.63 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.65 rifampicin
rpoC 766393 c.3024C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766408 c.3039C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.59 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.6 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 0.6 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.6 rifampicin
rpoC 766484 c.3115_3117delGTAinsAT frameshift_variant&missense_variant 0.55 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.52 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.49 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.47 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.47 rifampicin
rpoC 766534 c.3165C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766537 c.3168G>A synonymous_variant 0.45 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.45 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.48 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.52 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.49 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766576 c.3207C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.51 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.46 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.45 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.48 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.47 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.45 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.42 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.42 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.42 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.4 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.4 rifampicin
rpoC 766669 c.3300C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.41 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.52 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.5 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.5 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.52 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.53 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.52 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.54 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.54 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.51 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.5 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.52 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.39 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.39 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.39 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.39 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.38 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.38 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.38 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.37 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoC 766935 p.Glu1189Ala missense_variant 0.34 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>T synonymous_variant 0.28 rifampicin
rpoC 766961 p.Gly1198Leu missense_variant 0.28 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.29 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767041 c.3672G>C synonymous_variant 0.41 rifampicin
rpoC 767044 c.3675G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.62 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.63 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767182 c.3813G>C synonymous_variant 0.66 rifampicin
rpoC 767197 c.3828G>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>T synonymous_variant 0.58 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767266 c.3897G>C synonymous_variant 0.48 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.44 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.41 rifampicin
rpoC 767302 c.3933C>G synonymous_variant 0.29 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775832 c.2647_2649delGCCinsTG frameshift_variant&missense_variant 0.26 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775856 c.2625T>C synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 775885 p.Ile866Leu missense_variant 0.26 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Ile missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.17 clofazimine
bedaquiline
mmpL5 775916 c.2565T>A synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775939 p.Ala848Ser missense_variant 0.29 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.24 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.33 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.32 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.31 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.31 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.3 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.33 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.33 streptomycin
rpsL 781652 c.93T>G synonymous_variant 0.41 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.42 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.41 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.46 streptomycin
rpsL 781685 c.126G>C synonymous_variant 0.45 streptomycin
rpsL 781700 c.141G>A synonymous_variant 0.47 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.43 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.42 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.39 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.37 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.35 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.35 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.34 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.35 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.35 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.36 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.35 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.35 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.37 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.39 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.4 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.4 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.4 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.41 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.47 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.48 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.48 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.5 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.51 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.51 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.51 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.51 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.46 streptomycin Uncertain significance
rplC 800531 c.-278T>C upstream_gene_variant 0.19 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.18 linezolid
rplC 800564 c.-245C>T upstream_gene_variant 0.19 linezolid
rplC 800589 c.-220_-219delAGinsTC upstream_gene_variant 0.19 linezolid
rplC 800594 c.-215C>A upstream_gene_variant 0.2 linezolid
rplC 800597 c.-212A>C upstream_gene_variant 0.21 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.23 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.26 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.26 linezolid
rplC 800621 c.-188G>A upstream_gene_variant 0.28 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.4 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.42 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.42 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.38 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.38 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.36 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.37 linezolid
rplC 800745 c.-64_-62delCTCinsTG upstream_gene_variant 0.36 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.34 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.33 linezolid
rplC 800786 c.-23C>T upstream_gene_variant 0.21 linezolid
rplC 800838 c.30G>A synonymous_variant 0.16 linezolid
rplC 800844 c.36T>C synonymous_variant 0.18 linezolid
rplC 800856 c.48A>G synonymous_variant 0.22 linezolid
rplC 800865 c.57A>G synonymous_variant 0.23 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.25 linezolid
rplC 800873 p.Arg22Lys missense_variant 0.22 linezolid
rplC 800877 c.69A>C synonymous_variant 0.23 linezolid
rplC 800880 c.72A>G synonymous_variant 0.22 linezolid
rplC 800886 c.78G>C synonymous_variant 0.22 linezolid
rplC 800889 c.81C>G synonymous_variant 0.21 linezolid
rplC 800892 c.84G>C synonymous_variant 0.21 linezolid
rplC 800916 c.108A>G synonymous_variant 0.26 linezolid
rplC 800928 c.120C>T synonymous_variant 0.28 linezolid
rplC 800931 c.123G>C synonymous_variant 0.29 linezolid
rplC 800937 c.129A>G synonymous_variant 0.28 linezolid
rplC 800946 c.138T>C synonymous_variant 0.26 linezolid
rplC 800949 c.141T>C synonymous_variant 0.27 linezolid
rplC 800958 c.150G>C synonymous_variant 0.28 linezolid
rplC 800964 c.156G>C synonymous_variant 0.28 linezolid
rplC 800967 c.159C>T synonymous_variant 0.28 linezolid
rplC 800970 c.162T>C synonymous_variant 0.28 linezolid Not assoc w R - Interim
rplC 800985 c.177A>C synonymous_variant 0.21 linezolid
rplC 801132 c.324T>C synonymous_variant 0.19 linezolid
rplC 801147 c.339T>C synonymous_variant 0.2 linezolid
rplC 801150 c.342G>C synonymous_variant 0.2 linezolid
rplC 801153 c.345G>C synonymous_variant 0.2 linezolid
rplC 801156 c.348T>A synonymous_variant 0.21 linezolid
rplC 801168 c.360C>T synonymous_variant 0.22 linezolid
rplC 801171 c.363A>G synonymous_variant 0.21 linezolid
rplC 801174 c.366T>C synonymous_variant 0.2 linezolid
rplC 801220 c.412_414delAGTinsGG frameshift_variant&missense_variant 0.24 linezolid
rplC 801228 c.420T>C synonymous_variant 0.25 linezolid
rplC 801237 c.429G>C synonymous_variant 0.24 linezolid
rplC 801249 c.441T>G synonymous_variant 0.22 linezolid
rplC 801255 c.447C>T synonymous_variant 0.17 linezolid
rplC 801258 c.450C>G synonymous_variant 0.17 linezolid
Rv1129c 1254144 p.Thr131Pro missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303488 c.558G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303503 c.573G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303587 c.657G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303646 p.Ala239Val missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303653 c.723G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303974 c.1044C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304013 c.1083G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304068 p.Val380Ile missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304106 c.1176G>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304608 p.Thr560Val missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304652 c.1722C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305132 c.2202C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305135 c.2205C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305168 c.2238C>T synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305173 p.Asn748Ser missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305177 c.2247A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305181 c.2251T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305213 c.2283C>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305234 c.2304G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305237 c.2307A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305259 c.2329T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305267 c.2337C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305277 p.His783Asn missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305291 c.2361C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305339 c.2409C>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305360 c.2430G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
sigE 1364811 c.399A>G synonymous_variant 0.21 pyrazinamide
sigE 1364818 c.406_408delCTAinsTG frameshift_variant&stop_gained 0.25 pyrazinamide Uncertain significance
sigE 1364839 c.427T>C synonymous_variant 0.31 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.27 pyrazinamide
sigE 1364860 p.Arg150Lys missense_variant 0.26 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.26 pyrazinamide
sigE 1364872 p.Ile154Val missense_variant 0.3 pyrazinamide
sigE 1364877 c.465G>T synonymous_variant 0.31 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.31 pyrazinamide Uncertain significance
sigE 1364892 c.480C>G synonymous_variant 0.31 pyrazinamide
sigE 1364910 c.498G>A synonymous_variant 0.35 pyrazinamide
sigE 1364913 c.501C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1364919 c.507T>C synonymous_variant 0.36 pyrazinamide
sigE 1364926 p.Asn172Asp missense_variant 0.37 pyrazinamide
sigE 1364952 c.540A>G synonymous_variant 0.34 pyrazinamide
sigE 1364960 p.Gly183Asp missense_variant 0.29 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>G synonymous_variant 0.26 pyrazinamide
sigE 1364979 c.567C>G synonymous_variant 0.25 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.25 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.25 pyrazinamide
sigE 1364992 p.Pro194Ala missense_variant 0.25 pyrazinamide
sigE 1365006 c.594T>G synonymous_variant 0.25 pyrazinamide
sigE 1365015 c.603G>C synonymous_variant 0.25 pyrazinamide
sigE 1365018 c.606G>C synonymous_variant 0.25 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.22 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.19 pyrazinamide
sigE 1365036 c.624T>C synonymous_variant 0.19 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.18 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461132 p.Val30Ile missense_variant 0.23 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.21 bedaquiline
atpE 1461153 p.Ser37Ala missense_variant 0.21 bedaquiline Uncertain significance
atpE 1461159 p.Val39Ile missense_variant 0.21 bedaquiline Uncertain significance
atpE 1461164 c.120C>T synonymous_variant 0.22 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.22 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.22 bedaquiline
atpE 1461176 c.132G>A synonymous_variant 0.22 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.22 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.22 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.22 bedaquiline
atpE 1461188 c.144G>C synonymous_variant 0.23 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.24 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.2 bedaquiline
atpE 1461215 c.171C>T synonymous_variant 0.19 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472302 n.457_466delGGGTTCTCTCinsAGGATTTTTCTT non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1473752 n.95G>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474018 n.361G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474026 n.369C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474045 n.388C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474094 n.437C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474106 n.449A>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474107 n.450T>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474108 n.451C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474109 n.452A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474288 n.631C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474291 n.634T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474293 n.637_646delCCTCTCCGGA non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474305 n.648G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474417 n.761_767delCACGCGC non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474430 n.773delCinsTTG non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474432 n.775C>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474434 n.777_778insTG non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475378 n.1721A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475379 n.1722G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475396 n.1739_1740insTG non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475399 n.1742T>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475400 n.1743C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid Uncertain significance
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475408 n.1752delT non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475433 n.1776A>C non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475614 n.1957A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476740 n.3083G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476746 n.3089T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476748 n.3091A>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476753 n.3096T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476755 n.3098G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
inhA 1674342 c.141T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674353 p.Thr51Ile missense_variant 0.36 ethionamide
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.33 ethionamide
isoniazid
inhA 1674370 p.Lys57Pro missense_variant 0.34 ethionamide
isoniazid
inhA 1674375 c.174C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674399 c.198A>G synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674415 c.215_217delCCA disruptive_inframe_deletion 0.53 ethionamide
isoniazid
inhA 1674421 c.220_221insCGC disruptive_inframe_insertion 0.52 ethionamide
isoniazid
inhA 1674428 p.Gly76Glu missense_variant 0.51 ethionamide
isoniazid
inhA 1674432 c.231G>T synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674435 c.234G>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674443 p.Ala81Val missense_variant 0.53 ethionamide
isoniazid
inhA 1674450 c.249G>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.55 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674483 c.282G>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.53 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674542 p.Ala114Glu missense_variant 0.5 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.49 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.53 ethionamide
isoniazid
inhA 1674597 c.396G>A synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.54 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.51 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.55 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674699 c.498C>T synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674702 c.501G>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674741 c.540C>A synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.62 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674765 c.564C>G synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.66 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674810 c.609C>G synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674819 c.618G>C synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674830 p.Glu210Gly missense_variant 0.65 ethionamide
isoniazid
inhA 1674839 p.Ala213Glu missense_variant 0.63 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.64 ethionamide
isoniazid Uncertain significance
inhA 1674855 c.654C>G synonymous_variant 0.62 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674876 c.675C>G synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674892 p.Asn231Asp missense_variant 0.5 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.35 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674927 c.726G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674930 c.729C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674937 p.Leu246Met missense_variant 0.2 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.19 ethionamide
isoniazid
rpsA 1833540 c.-2_-1delATinsC upstream_gene_variant 0.18 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.26 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.47 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.45 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.46 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.53 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.55 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.54 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.62 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.63 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.62 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.62 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.61 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.6 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.56 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.56 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.54 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.53 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.54 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.53 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.53 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.54 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.52 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.51 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.5 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.49 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.52 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.51 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.49 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.52 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.5 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.5 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.51 pyrazinamide
rpsA 1834015 c.474G>T synonymous_variant 0.54 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.54 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.5 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.49 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.48 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.48 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.5 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834225 c.684C>A synonymous_variant 0.59 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.55 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.6 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.63 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.62 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.58 pyrazinamide
rpsA 1834527 p.Arg329His missense_variant 0.57 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.57 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.58 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.56 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.59 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.6 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.5 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.48 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.47 pyrazinamide Uncertain significance
rpsA 1834756 c.1215G>A synonymous_variant 0.46 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.45 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.47 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.45 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834792 c.1251G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.29 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.48 linezolid
tsnR 1853370 c.-236_-234delGCAinsAC upstream_gene_variant 0.5 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.53 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.54 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.59 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.59 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.58 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.49 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.48 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.45 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.47 linezolid
tsnR 1853480 c.-126G>C upstream_gene_variant 0.46 linezolid
tsnR 1853490 c.-116C>G upstream_gene_variant 0.47 linezolid
tsnR 1853495 c.-111G>T upstream_gene_variant 0.45 linezolid
tsnR 1853516 c.-90C>G upstream_gene_variant 0.39 linezolid
tsnR 1853522 c.-84C>T upstream_gene_variant 0.35 linezolid
tsnR 1853528 c.-78G>C upstream_gene_variant 0.31 linezolid
tsnR 1853531 c.-75A>G upstream_gene_variant 0.3 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.28 linezolid
tsnR 1853543 c.-63C>T upstream_gene_variant 0.23 linezolid
tsnR 1853555 c.-51C>G upstream_gene_variant 0.17 linezolid
tsnR 1853561 c.-45G>C upstream_gene_variant 0.17 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2101960 c.1083A>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101969 p.Glu358Asp missense_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101980 p.Asn355Asp missense_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Gly missense_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101993 c.1050A>G synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102005 c.1038G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102015 p.Val343Ala missense_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102019 p.Tyr342His missense_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.27 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102049 p.Val332Met missense_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102053 c.990G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102056 c.987G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102062 p.Glu327Asp missense_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102065 c.978G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102068 c.975T>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102071 c.972C>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102083 c.960G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102392 c.651C>T synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102398 c.645C>T synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102401 c.642T>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102407 c.636T>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102436 p.His203Asn missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102437 c.606G>C synonymous_variant 0.2 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102443 c.600A>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102452 c.589_591delTTGinsCC frameshift_variant&missense_variant 0.21 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102455 c.588G>A synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102460 p.His195Tyr missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102461 c.580_582delGAGinsAT frameshift_variant&missense_variant 0.2 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102469 c.574C>T synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102482 c.561A>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102494 c.549T>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102509 c.534T>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102512 c.531G>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102518 c.525T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102771 p.His91Arg missense_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102773 c.270C>A synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102785 p.Leu86Phe missense_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102791 c.252A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102798 p.Val82Ala missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102800 c.243T>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102812 c.231T>C synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102824 c.219G>T synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102830 c.211_213delCCGinsTC frameshift_variant&missense_variant 0.32 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102836 c.207T>A synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102842 c.201A>G synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102845 c.198A>C synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102854 c.187_189delATCinsCG frameshift_variant&missense_variant 0.31 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102857 c.186T>C synonymous_variant 0.31 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102860 c.183G>C synonymous_variant 0.31 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102863 c.180C>G synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102866 c.177C>G synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2102869 c.174G>T synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2102899 c.144T>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102908 c.135C>T synonymous_variant 0.21 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102911 c.132G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102925 p.Ile40Val missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102929 c.114T>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155214 p.Trp300Arg missense_variant 1.0 isoniazid Uncertain significance
katG 2156316 c.-205G>A upstream_gene_variant 0.99 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.53 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.54 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.49 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.33 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.27 isoniazid
kasA 2517994 c.-121C>G upstream_gene_variant 0.19 isoniazid
kasA 2518488 p.Ser125Thr missense_variant 0.19 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.3 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.3 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.42 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.46 isoniazid
kasA 2518532 c.418C>T synonymous_variant 0.49 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.53 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.53 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.54 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.54 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.54 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.55 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.56 isoniazid
kasA 2518594 c.480C>T synonymous_variant 0.55 isoniazid
kasA 2518597 c.483C>T synonymous_variant 0.54 isoniazid
kasA 2518603 c.489G>A synonymous_variant 0.55 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.55 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.55 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.56 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.54 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.51 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.49 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.49 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.47 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.47 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.46 isoniazid
kasA 2518696 c.582C>T synonymous_variant 0.47 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.45 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.45 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.45 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.51 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.53 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.53 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.55 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.53 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.51 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.52 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.53 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.52 isoniazid
kasA 2518822 c.708C>A synonymous_variant 0.49 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.49 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.42 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.38 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.38 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.35 isoniazid
kasA 2518882 c.768C>T synonymous_variant 0.33 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.32 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.3 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.25 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.21 isoniazid
kasA 2519113 p.Gln333His missense_variant 0.18 isoniazid
kasA 2519128 c.1014G>A synonymous_variant 0.24 isoniazid
kasA 2519131 c.1017G>C synonymous_variant 0.23 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.25 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.25 isoniazid
kasA 2519158 c.1044C>G synonymous_variant 0.26 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.26 isoniazid
kasA 2519185 c.1071C>G synonymous_variant 0.27 isoniazid
kasA 2519194 c.1080G>C synonymous_variant 0.27 isoniazid
kasA 2519195 p.Thr361Ser missense_variant 0.27 isoniazid
kasA 2519203 c.1089C>T synonymous_variant 0.27 isoniazid
kasA 2519209 c.1095C>G synonymous_variant 0.26 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.26 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.26 isoniazid
kasA 2519245 c.1131T>C synonymous_variant 0.25 isoniazid
ahpC 2726579 c.387T>C synonymous_variant 0.18 isoniazid
ahpC 2726582 c.390G>C synonymous_variant 0.18 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.18 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.18 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.19 isoniazid
ahpC 2726624 c.432C>T synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ahpC 2726638 p.Ala149Val missense_variant 0.18 isoniazid
ahpC 2726648 c.456T>A synonymous_variant 0.19 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.19 isoniazid
ahpC 2726690 c.498C>T synonymous_variant 0.19 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.19 isoniazid
folC 2746999 c.600T>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747002 c.597T>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747005 c.592_594delAGCinsGT frameshift_variant&synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747032 c.567A>T synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747035 c.562_564delAACinsCG frameshift_variant&missense_variant 0.32 para-aminosalicylic_acid
folC 2747040 p.Ile187Val missense_variant 0.32 para-aminosalicylic_acid
folC 2747041 c.558G>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747053 c.546C>T synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747062 c.537A>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747074 c.525G>C synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747077 c.522G>A synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747080 c.519C>G synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747092 c.507C>T synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747098 c.501C>G synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747101 c.498G>T synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747129 p.Ala157Gly missense_variant 0.32 para-aminosalicylic_acid
Rv2477c 2782501 c.1542T>C synonymous_variant 0.19 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782522 c.1521G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783350 c.693T>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783380 c.663C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 c.610_611delAGinsTC synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783456 p.Gln196Leu missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.51 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783516 c.526_527delTCinsAG synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783545 c.498C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783575 c.468G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783651 p.His131Ser missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662