TB-Profiler result

Run: SRR20969731
Summary

Run ID: SRR20969731

Sample name:

Date: 2024-04-15T00:50:29.546750

Number of reads: 6537697

Percentage reads mapped: 50.87

Median coverage: 124.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.96
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.96
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
p.Ala388Gly Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.658_660delCGAinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.19 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303588 c.658_660delCGAinsAG frameshift_variant&synonymous_variant 0.31 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.25 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance Mutation from literature
embB 4247580 p.Ala356Val missense_variant 0.38 ethambutol Uncertain significance Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.23 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 708 c.708T>C synonymous_variant 0.18 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.27 isoniazid
dnaA 723 c.723A>G synonymous_variant 0.29 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.39 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.4 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.41 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.4 isoniazid Uncertain significance
dnaA 798 c.798C>T synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 801 c.801G>C synonymous_variant 0.41 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.41 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.42 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 840 c.840G>A synonymous_variant 0.43 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.4 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.39 isoniazid
dnaA 864 c.864C>T synonymous_variant 0.33 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.22 isoniazid
gyrB 6157 c.918C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6170 p.His311Ala missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6203 c.964_966delAGCinsTCG synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAGC synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6229 c.990G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6248 c.1009_1011delCTAinsTG frameshift_variant&stop_gained 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrB 6253 c.1014G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6817 c.1578G>A synonymous_variant 0.18 levofloxacin Not assoc w R
moxifloxacin Not assoc w R - Interim
gyrA 7335 p.Leu12Val missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7340 p.Asp13Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7349 c.48A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7418 c.117C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7421 c.120G>A synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.6 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7526 c.225G>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7569 p.Ala90Ser missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7625 c.324G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7655 c.354G>A synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7697 c.396C>T synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7715 c.414G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>T synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 7911 p.Ala204Cys missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 7922 c.621T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7928 p.Asp209Glu missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 7934 c.633C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7942 p.Glu214Ala missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7951 p.Ala217Glu missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7958 c.657C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7963 p.Gly221Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7970 c.669T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7973 c.672A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8258 c.957G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8273 c.972C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8366 c.1065G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8417 c.1116C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8492 c.1191G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8585 c.1284C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8591 c.1290C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8600 c.1299G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8606 c.1305C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8649 p.Arg450Lys missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8711 c.1410A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8720 c.1419G>A synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.48 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.48 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8769 p.His490Tyr missense_variant 0.47 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8786 c.1485T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8788 p.Thr496Ser missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8993 c.1692C>T synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.48 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9064 p.Ser588Leu missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.31 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9146 c.1845C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9197 c.1896G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9266 p.Asp655Glu missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9288 p.Val663Met missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9318 c.2017C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 491151 c.369G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491220 c.438C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491223 c.441C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491226 c.444C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491229 c.447C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.49 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491307 c.525C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491328 c.546C>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491355 c.573C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491364 c.582T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491382 c.600G>A synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491409 c.627G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491415 c.633A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491417 p.Arg212Leu missense_variant 0.27 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491420 p.Glu213Ala missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491429 p.Ala216Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491436 c.654T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491439 p.Asp219Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491442 c.660A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491443 p.Ser221Asp missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491447 p.Val222Ala missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491490 c.708C>T synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491539 c.757_759delTCGinsAGC synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_782delAGinsTC synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575714 p.Tyr123Asn missense_variant 0.23 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575740 c.393G>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.41 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.43 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.43 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.43 ethionamide
isoniazid Not assoc w R - Interim
mshA 575818 c.471G>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.42 ethionamide
isoniazid
mshA 575840 c.494dupC frameshift_variant 0.47 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575844 c.498delC frameshift_variant 0.47 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575864 c.517T>C synonymous_variant 0.51 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.45 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575892 p.Ala182Gly missense_variant 0.36 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.66 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.32 ethionamide
isoniazid
mshA 575920 c.573C>T synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575925 p.Gly193Ala missense_variant 0.28 ethionamide
isoniazid
mshA 575929 c.582C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575932 c.585G>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575935 c.588G>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575953 c.606G>T synonymous_variant 0.28 ethionamide
isoniazid
mshA 575959 c.612G>A synonymous_variant 0.27 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.18 ethionamide
isoniazid
ccsA 620625 p.Ile245Met missense_variant 0.99 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734391 c.138C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734397 c.144C>T synonymous_variant 0.21 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.22 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.27 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.28 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.4 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.43 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.44 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.46 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.52 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.45 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.42 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.32 rifampicin
nusG 734607 c.354C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734614 p.Ala121Ser missense_variant 0.27 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.23 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.21 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.17 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.24 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.23 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.23 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.23 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.23 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.22 rifampicin
nusG 734889 c.636G>A synonymous_variant 0.24 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.24 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.24 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.23 rifampicin
nusG 734931 c.678A>G synonymous_variant 0.23 rifampicin
nusG 734934 c.681G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.39 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>G synonymous_variant 0.43 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.46 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.47 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.49 rifampicin
rpoB 760155 p.Lys117Arg missense_variant 0.47 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.52 rifampicin
rpoB 760178 c.372G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>G synonymous_variant 0.5 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760187 c.381G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.55 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.5 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.48 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.47 rifampicin
rpoB 760323 c.517C>T synonymous_variant 0.48 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.5 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.49 rifampicin
rpoB 760354 p.Glu183Ala missense_variant 0.42 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.42 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.42 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.4 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760449 p.Thr215Leu missense_variant 0.44 rifampicin
rpoB 760460 c.654G>T synonymous_variant 0.45 rifampicin
rpoB 760463 c.657C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>T synonymous_variant 0.5 rifampicin Not assoc w R
rpoB 760514 c.708C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760532 c.726T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Arg missense_variant 0.49 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760556 p.Glu250Asp missense_variant 0.53 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.49 rifampicin Uncertain significance
rpoB 760587 p.Thr261Ala missense_variant 0.48 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.48 rifampicin
rpoB 760593 p.Gly263Asn missense_variant 0.48 rifampicin
rpoB 760596 p.Thr264Ser missense_variant 0.48 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.36 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.3 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.27 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.27 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.29 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.31 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.41 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.56 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.56 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.56 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.57 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.56 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.55 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.56 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.55 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.59 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.61 rifampicin
rpoB 761306 c.1500C>G synonymous_variant 0.53 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>C synonymous_variant 0.44 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.39 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.38 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761373 p.Val523His missense_variant 0.3 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.22 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761483 c.1677G>C synonymous_variant 0.16 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.23 rifampicin
rpoB 761502 c.1696_1698delCCCinsTG frameshift_variant&missense_variant 0.25 rifampicin
rpoB 761508 c.1702_1704delTCTinsGC frameshift_variant&missense_variant 0.26 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.34 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.51 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.58 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.52 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.51 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.43 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.41 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.37 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.3 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.3 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.25 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsAG frameshift_variant&missense_variant 0.24 rifampicin
rpoB 761728 p.Ser641Thr missense_variant 0.25 rifampicin
rpoB 761798 c.1992C>T synonymous_variant 0.22 rifampicin
rpoB 761814 p.Ala670Thr missense_variant 0.19 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.23 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.21 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.22 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.22 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.22 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.24 rifampicin
rpoB 761881 p.Ala692Val missense_variant 0.29 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.3 rifampicin
rpoB 761897 c.2091C>G synonymous_variant 0.32 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.31 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.32 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.32 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.31 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.35 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.42 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAG frameshift_variant&missense_variant 0.54 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.51 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.52 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.54 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.51 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.52 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.53 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.54 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>T synonymous_variant 0.59 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.56 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.52 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.51 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.5 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.51 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.52 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.52 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.51 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.52 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.49 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.47 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.47 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Ala missense_variant 0.4 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.34 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.34 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.31 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.28 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.26 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.26 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.27 rifampicin
rpoC 762728 c.-642C>G upstream_gene_variant 0.19 rifampicin
rpoB 762735 p.Ala977Asn missense_variant 0.21 rifampicin
rpoB 762749 c.2943C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.34 rifampicin
rpoB 762760 p.Cys985Ser missense_variant 0.34 rifampicin Uncertain significance
rpoB 762768 p.Pro988Ala missense_variant 0.43 rifampicin Uncertain significance
rpoB 762782 c.2976T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.47 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.47 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.53 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762814 p.Met1003Arg missense_variant 0.56 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.66 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.28 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.71 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.71 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763079 c.-291C>T upstream_gene_variant 0.67 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.6 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.58 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.49 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.48 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.49 rifampicin Uncertain significance
rpoB 763214 c.3408T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763227 c.3421C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763262 c.-108C>A upstream_gene_variant 0.32 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.31 rifampicin
rpoC 763268 c.-102C>A upstream_gene_variant 0.3 rifampicin
rpoB 763283 c.3477T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763396 c.27A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.58 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.6 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.59 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.55 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.55 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.57 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.56 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.55 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.5 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.4 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.35 rifampicin
rpoC 763790 p.Glu141Thr missense_variant 0.28 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.22 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.24 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.24 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.3 rifampicin Uncertain significance
rpoC 763966 c.597C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.43 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.43 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.42 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.4 rifampicin
rpoC 764030 p.Asp221Asn missense_variant 0.39 rifampicin Uncertain significance
rpoC 764039 p.Ser224Asp missense_variant 0.4 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.4 rifampicin
rpoC 764048 p.Thr227Val missense_variant 0.4 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.45 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.42 rifampicin
rpoC 764085 p.Asn239Thr missense_variant 0.41 rifampicin Uncertain significance
rpoC 764087 p.Leu240Val missense_variant 0.43 rifampicin Uncertain significance
rpoC 764098 c.729A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764134 c.765C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764169 p.Asn267Thr missense_variant 0.52 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.5 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Thr missense_variant 0.48 rifampicin Uncertain significance
rpoC 764213 p.Arg282Lys missense_variant 0.48 rifampicin Uncertain significance
rpoC 764248 c.879C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764255 c.886C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764272 c.903G>C synonymous_variant 0.53 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.49 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.49 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.57 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.51 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.49 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.5 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.5 rifampicin
rpoC 764452 c.1083T>G synonymous_variant 0.5 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.57 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.57 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.62 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.61 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.62 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.63 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.62 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>G synonymous_variant 0.61 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.62 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.56 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.55 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.53 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.43 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.39 rifampicin
rpoC 765076 c.1707A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.33 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.34 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765121 c.1752G>C synonymous_variant 0.25 rifampicin
rpoC 765220 c.1851A>G synonymous_variant 0.21 rifampicin
rpoC 765232 c.1863G>C synonymous_variant 0.21 rifampicin
rpoC 765234 p.Ala622Val missense_variant 0.21 rifampicin
rpoC 765277 c.1908G>T synonymous_variant 0.26 rifampicin
rpoC 765281 p.Thr638Asp missense_variant 0.26 rifampicin Uncertain significance
rpoC 765300 p.Val644Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765305 p.Ile646Val missense_variant 0.36 rifampicin Uncertain significance
rpoC 765311 p.Ala648Thr missense_variant 0.36 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.37 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.4 rifampicin Uncertain significance
rpoC 765339 p.Gln657Arg missense_variant 0.46 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765403 c.2034G>C synonymous_variant 0.51 rifampicin
rpoC 765404 p.Leu679Thr missense_variant 0.5 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765418 c.2049C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.51 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.48 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.48 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.51 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.55 rifampicin
rpoC 765607 c.2238C>G synonymous_variant 0.54 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.54 rifampicin Uncertain significance
rpoC 765628 c.2259G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.53 rifampicin
rpoC 765673 p.Asp768Glu missense_variant 0.54 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765718 p.Asp783Glu missense_variant 0.58 rifampicin Uncertain significance
rpoC 765721 c.2352G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.57 rifampicin
rpoC 765742 p.Glu791Asp missense_variant 0.56 rifampicin Uncertain significance
rpoC 765787 c.2418C>T synonymous_variant 0.58 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.56 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.57 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.55 rifampicin Uncertain significance
rpoC 765904 c.2535C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.57 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Gly missense_variant 0.24 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.25 rifampicin
rpoC 766294 c.2925C>T synonymous_variant 0.29 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.29 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.29 rifampicin
rpoC 766306 c.2937C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766309 c.2940G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.3 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.32 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.42 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.47 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.5 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.54 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.56 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.57 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.58 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.57 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.59 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.56 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.55 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.55 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.58 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.54 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.53 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.5 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.49 rifampicin
rpoC 766537 c.3168G>A synonymous_variant 0.47 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.47 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.48 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.5 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.5 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766576 c.3207C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.5 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.46 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.46 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.49 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.47 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.44 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.44 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.45 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.45 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.46 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.49 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.54 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.54 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.54 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766726 c.3357T>C synonymous_variant 0.57 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.6 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.63 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.62 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.59 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.58 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.57 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.45 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.38 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.38 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.37 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.38 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.38 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.38 rifampicin
rpoC 766918 c.3549C>A synonymous_variant 0.38 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.38 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.39 rifampicin
rpoC 766935 p.Glu1189Ala missense_variant 0.39 rifampicin
rpoC 766942 c.3573C>G synonymous_variant 0.41 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>G synonymous_variant 0.4 rifampicin
rpoC 766961 p.Gly1198Leu missense_variant 0.39 rifampicin
rpoC 766975 c.3606C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.61 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>G synonymous_variant 0.66 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767191 c.3822C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767278 c.3909T>C synonymous_variant 0.28 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775817 c.2664T>C synonymous_variant 0.3 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775826 c.2655G>C synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 775832 c.2649C>G synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 775838 c.2643G>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775844 c.2637G>A synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775880 p.Asn867Lys missense_variant 0.26 clofazimine
bedaquiline
mmpL5 775885 p.Ile866Leu missense_variant 0.34 clofazimine
bedaquiline
mmpL5 775886 c.2595A>G synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775906 p.Lys859Gln missense_variant 0.24 clofazimine
bedaquiline
mmpL5 775907 c.2572_2574delCTCinsTG frameshift_variant&synonymous_variant 0.29 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775910 c.2571G>C synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.47 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775939 p.Ala848Ser missense_variant 0.29 clofazimine
bedaquiline
mmpL5 775943 c.2538C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.27 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.23 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpL5 778931 c.-451A>G upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.2 streptomycin
rpsL 781592 c.33T>C synonymous_variant 0.26 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.26 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.26 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.26 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.25 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.26 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.27 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.36 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.39 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.44 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.46 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.44 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.42 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.41 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.41 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.4 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.41 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.42 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.42 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.43 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.45 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.46 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.48 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.48 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.48 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.49 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.49 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.48 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.49 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.49 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.48 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.46 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.47 streptomycin Uncertain significance
rplC 800480 c.-329G>T upstream_gene_variant 0.19 linezolid
rplC 800498 c.-311G>A upstream_gene_variant 0.35 linezolid
rplC 800516 c.-293G>C upstream_gene_variant 0.4 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.49 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.5 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.52 linezolid
rplC 800574 c.-235_-233delGTCinsACT upstream_gene_variant 0.51 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.55 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.54 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.55 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.57 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.55 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.55 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.54 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.56 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.49 linezolid
rplC 800699 c.-110G>A upstream_gene_variant 0.47 linezolid
rplC 800700 c.-109C>A upstream_gene_variant 0.47 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.45 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.44 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.37 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.37 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.33 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.32 linezolid
rplC 800892 c.84G>C synonymous_variant 0.22 linezolid
rplC 800916 c.108A>G synonymous_variant 0.37 linezolid
rplC 800931 c.123G>C synonymous_variant 0.4 linezolid
rplC 800937 c.129A>G synonymous_variant 0.4 linezolid
rplC 800946 c.138T>C synonymous_variant 0.39 linezolid
rplC 800949 c.141T>C synonymous_variant 0.39 linezolid
rplC 800950 c.142_143delAGinsTC synonymous_variant 0.39 linezolid
rplC 800964 c.156G>C synonymous_variant 0.39 linezolid
rplC 800967 c.159C>T synonymous_variant 0.4 linezolid
rplC 800970 c.162T>C synonymous_variant 0.39 linezolid Not assoc w R - Interim
rplC 800985 c.177A>T synonymous_variant 0.35 linezolid
rplC 801009 c.201A>C synonymous_variant 0.3 linezolid
rplC 801019 c.211_213delACCinsGG frameshift_variant&missense_variant 0.31 linezolid
rplC 801030 c.222C>G synonymous_variant 0.32 linezolid
rplC 801039 c.231A>G synonymous_variant 0.28 linezolid
rplC 801045 c.237A>G synonymous_variant 0.17 linezolid
rplC 801153 c.345G>C synonymous_variant 0.19 linezolid
rplC 801156 c.348T>C synonymous_variant 0.21 linezolid
rplC 801171 c.363A>G synonymous_variant 0.26 linezolid
rplC 801174 c.366T>C synonymous_variant 0.26 linezolid
rplC 801176 p.Phe123Tyr missense_variant 0.27 linezolid
rplC 801210 c.402T>C synonymous_variant 0.39 linezolid
rplC 801220 p.Ser138Gly missense_variant 0.36 linezolid
rplC 801228 c.420T>C synonymous_variant 0.38 linezolid
rplC 801231 c.423C>G synonymous_variant 0.38 linezolid
rplC 801237 c.429G>A synonymous_variant 0.38 linezolid
rplC 801249 c.441T>G synonymous_variant 0.38 linezolid
rplC 801255 c.447C>T synonymous_variant 0.34 linezolid
rplC 801258 c.450C>G synonymous_variant 0.34 linezolid
rplC 801267 c.459A>C synonymous_variant 0.29 linezolid
rplC 801270 c.462T>C synonymous_variant 0.28 linezolid
rplC 801271 c.463_465delGCCinsTG frameshift_variant&missense_variant 0.28 linezolid
rplC 801276 c.468G>C synonymous_variant 0.28 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.27 linezolid
rplC 801307 c.499_501delGCCinsTA frameshift_variant&missense_variant 0.2 linezolid
rplC 801312 c.504G>C synonymous_variant 0.18 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303470 c.540T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303583 p.Thr218Ser missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303620 c.690C>T synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303632 c.702T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304798 p.Ala623Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304845 p.Ala639Thr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>G synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304857 p.Thr643Ser missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304868 c.1938G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304874 c.1944C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305339 c.2409C>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305345 c.2415C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305348 c.2418C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305360 c.2430G>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305418 p.Val830Ile missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305427 c.2497C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
sigE 1364826 c.414C>G synonymous_variant 0.2 pyrazinamide
sigE 1364860 p.Arg150Ser missense_variant 0.19 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.22 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.28 pyrazinamide
sigE 1364910 c.498G>C synonymous_variant 0.34 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.37 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.41 pyrazinamide
sigE 1364926 p.Asn172Asp missense_variant 0.43 pyrazinamide
sigE 1364940 c.528C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
sigE 1364960 p.Gly183Asp missense_variant 0.4 pyrazinamide
sigE 1364976 c.564T>G synonymous_variant 0.37 pyrazinamide
sigE 1364979 c.567C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1364980 c.568T>C synonymous_variant 0.36 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.36 pyrazinamide
sigE 1364989 c.577C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
sigE 1364992 c.580_582delCCGinsGC frameshift_variant&missense_variant 0.35 pyrazinamide Uncertain significance
sigE 1365003 c.591T>C synonymous_variant 0.34 pyrazinamide
sigE 1365006 c.594T>G synonymous_variant 0.34 pyrazinamide
sigE 1365009 c.597C>G synonymous_variant 0.34 pyrazinamide
sigE 1365012 c.600G>C synonymous_variant 0.35 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.31 pyrazinamide
sigE 1365036 c.624T>G synonymous_variant 0.29 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.26 pyrazinamide
sigE 1365048 c.636G>A synonymous_variant 0.26 pyrazinamide
sigE 1365052 p.Ile214Val missense_variant 0.23 pyrazinamide Uncertain significance
sigE 1365063 c.651A>C synonymous_variant 0.17 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461083 c.39T>C synonymous_variant 0.18 bedaquiline
atpE 1461086 c.42A>T synonymous_variant 0.19 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.21 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.26 bedaquiline
atpE 1461132 c.88_90delGTCinsAT frameshift_variant&missense_variant 0.29 bedaquiline
atpE 1461147 c.103_105delCTTinsTG frameshift_variant&missense_variant 0.29 bedaquiline
atpE 1461153 p.Ser37Ala missense_variant 0.3 bedaquiline Uncertain significance
atpE 1461159 p.Val39Ile missense_variant 0.3 bedaquiline Uncertain significance
atpE 1461164 c.120C>T synonymous_variant 0.3 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.28 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.28 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.28 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.28 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.28 bedaquiline
atpE 1461215 c.171C>T synonymous_variant 0.27 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.25 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472302 n.457_458insT non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472310 n.465_466insG non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473939 n.282C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473964 n.307T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473965 n.308G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474016 n.359C>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474026 n.369C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474105 n.448delTinsCG non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474116 n.459G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630_647delTCCTTTTCCTCTCCGGAGinsCTCTCTTT non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474415 n.760_765delACACGC non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474426 n.769T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474428 n.771C>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474430 n.773C>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474432 n.775C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474438 n.781delAinsGT non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475239 n.1582_1583delACinsTGGCAG non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475241 n.1584C>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475246 n.1589_1590insT non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475249 n.1594_1598delACTCC non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475265 n.1608_1611delGTGTinsTGA non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475272 n.1615G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475278 n.1621delGinsCC non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475378 n.1721A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475379 n.1722G>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475396 n.1739_1740insTG non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475399 n.1742T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475400 n.1743C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid Uncertain significance
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475408 n.1752delT non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475428 n.1771G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475433 n.1776A>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476746 n.3089T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476748 n.3091A>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476753 n.3096T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476755 n.3098G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
inhA 1673646 c.-556T>C upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.21 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673679 c.-523T>A upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1673682 c.-520G>C upstream_gene_variant 0.25 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673698 p.Ser87Ala missense_variant 0.24 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.23 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.25 ethionamide
isoniazid
inhA 1673724 c.-478A>G upstream_gene_variant 0.25 ethionamide
isoniazid
inhA 1673730 c.-472C>G upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.25 ethionamide
isoniazid
inhA 1673757 c.-445G>A upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.26 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1673787 c.-415G>C upstream_gene_variant 0.21 ethionamide
isoniazid
fabG1 1673797 p.Ala120Thr missense_variant 0.17 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674507 c.306G>A synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.32 ethionamide
isoniazid
inhA 1674534 c.333G>T synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.3 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.3 ethionamide
isoniazid
inhA 1674570 c.369G>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.36 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.37 ethionamide
isoniazid
inhA 1674615 p.Met138Ile missense_variant 0.36 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.42 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 0.38 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674735 c.534G>A synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674742 p.Lys181Pro missense_variant 0.38 ethionamide
isoniazid
inhA 1674745 p.Tyr182His missense_variant 0.4 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674750 c.549T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674830 p.Glu210Gly missense_variant 0.32 ethionamide
isoniazid
inhA 1674837 c.636C>T synonymous_variant 0.32 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674839 p.Ala213Glu missense_variant 0.32 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.35 ethionamide
isoniazid Uncertain significance
inhA 1674870 c.669T>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.39 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674892 p.Asn231Asp missense_variant 0.38 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.3 ethionamide
isoniazid
inhA 1674907 c.706_708delACGinsGC frameshift_variant&missense_variant 0.3 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674927 c.726G>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674933 c.732G>A synonymous_variant 0.3 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674942 c.741T>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674945 c.744C>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.19 ethionamide
isoniazid
rpsA 1833540 c.-2_-1delATinsC upstream_gene_variant 0.19 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.26 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.4 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.41 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.41 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.43 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.45 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.47 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1833664 c.123C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.55 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.55 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.55 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.58 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.58 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.57 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.57 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.57 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.61 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.61 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.6 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.62 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.53 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.53 pyrazinamide
rpsA 1834096 c.555G>T synonymous_variant 0.51 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.39 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.41 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.42 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.46 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.55 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.53 pyrazinamide
rpsA 1834364 c.823_825delTCAinsAGC synonymous_variant 0.5 pyrazinamide
rpsA 1834375 c.834G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.56 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.55 pyrazinamide
rpsA 1834527 p.Arg329Gln missense_variant 0.54 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834598 c.1057C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.53 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.49 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.5 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.39 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.38 pyrazinamide Uncertain significance
rpsA 1834756 c.1215G>A synonymous_variant 0.37 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.36 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.36 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.34 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.24 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.37 linezolid
tsnR 1853370 c.-236_-234delGCAinsAC upstream_gene_variant 0.36 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.32 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.3 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.29 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.29 linezolid
tsnR 1853401 c.-205A>G upstream_gene_variant 0.3 linezolid
tsnR 1853403 c.-203A>G upstream_gene_variant 0.31 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 0.31 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.34 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.37 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.37 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.34 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.34 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.33 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.33 linezolid
tsnR 1853480 c.-126G>C upstream_gene_variant 0.33 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.33 linezolid
tsnR 1853490 c.-116C>G upstream_gene_variant 0.34 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.34 linezolid
tsnR 1853516 c.-90C>G upstream_gene_variant 0.28 linezolid
tsnR 1853523 c.-83_-82delCGinsAA upstream_gene_variant 0.26 linezolid
tsnR 1853528 c.-78G>C upstream_gene_variant 0.26 linezolid
tsnR 1853531 c.-75A>G upstream_gene_variant 0.26 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.27 linezolid
tsnR 1853543 c.-63C>T upstream_gene_variant 0.27 linezolid
tsnR 1853552 c.-54C>G upstream_gene_variant 0.27 linezolid
tsnR 1853561 c.-45G>C upstream_gene_variant 0.25 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917982 p.Gly15Ser missense_variant 0.83 capreomycin
ndh 2102386 c.657G>C synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102398 c.645C>T synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102401 c.642T>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102407 c.636T>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.33 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.24 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.17 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.28 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.34 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.37 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.39 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.4 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.38 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.39 isoniazid
kasA 2518795 c.681C>A synonymous_variant 0.39 isoniazid
kasA 2518796 c.682C>A synonymous_variant 0.39 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.4 isoniazid
kasA 2518822 c.708C>A synonymous_variant 0.4 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.4 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.41 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.43 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.43 isoniazid
kasA 2518876 c.762C>T synonymous_variant 0.35 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.34 isoniazid
kasA 2518885 c.771T>G synonymous_variant 0.31 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.27 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.2 isoniazid
kasA 2519044 c.930G>C synonymous_variant 0.2 isoniazid
kasA 2519047 c.933C>T synonymous_variant 0.23 isoniazid
kasA 2519059 c.945G>C synonymous_variant 0.26 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.28 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.26 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.26 isoniazid
kasA 2519077 c.963G>C synonymous_variant 0.26 isoniazid
kasA 2519083 c.969C>G synonymous_variant 0.27 isoniazid
kasA 2519089 c.975C>G synonymous_variant 0.26 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.26 isoniazid
kasA 2519097 p.Val328Glu missense_variant 0.26 isoniazid
kasA 2519104 c.990T>C synonymous_variant 0.26 isoniazid
kasA 2519110 p.Asp332Glu missense_variant 0.27 isoniazid
kasA 2519113 p.Gln333His missense_variant 0.27 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.28 isoniazid
kasA 2519128 c.1014G>A synonymous_variant 0.28 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.29 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.28 isoniazid
kasA 2519176 c.1062G>A synonymous_variant 0.25 isoniazid
kasA 2519185 c.1071C>G synonymous_variant 0.22 isoniazid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782489 c.1552_1554delAACinsGA frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782496 p.Asp516Ala missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.23 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782510 c.1533G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782570 c.1473C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782582 c.1461C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783015 p.Ser343Thr missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783122 c.921G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783364 c.679C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783380 c.663C>T synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.52 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783432 p.Ser204Ala missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783444 p.Gln200Ala missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.59 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783634 p.Leu137Ile missense_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783646 p.Asp133Asn missense_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783767 c.276C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783788 c.255T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783837 p.Thr69Ser missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783842 c.201C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783847 p.Thr66Pro missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783848 c.195C>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783871 c.171_172insCC frameshift_variant 0.28 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783874 c.167_168delAG frameshift_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783883 c.160T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783935 c.108C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783950 c.93C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 p.Tyr29Leu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064908 c.1284C>T synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1162_1164delGTGinsAT frameshift_variant&missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065634 c.558G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065637 c.555A>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065640 c.552T>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065649 c.543T>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065652 c.540C>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065661 c.531A>G synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065664 c.528G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065667 c.525A>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065675 p.Phe173Leu missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065676 c.516G>A synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065697 c.493_495delATCinsGG frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065703 c.489A>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065706 c.486G>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065709 c.483C>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065715 c.475_477delTATinsCC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065727 c.465C>G synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065732 c.460T>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065736 c.456C>T synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065743 p.Thr150Ile missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065748 c.444T>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065754 c.438C>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065757 c.435C>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065766 c.426G>A synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066129 c.63G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066141 c.51G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066146 c.46T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066147 c.45G>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066155 p.Ser13Ala missense_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067711 p.Ser79Thr missense_variant 0.18 para-aminosalicylic_acid
thyX 3067717 p.Ser77Gly missense_variant 0.2 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067761 p.Arg62Gln missense_variant 0.28 para-aminosalicylic_acid
thyX 3067763 c.183C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067770 p.Gly59Ala missense_variant 0.28 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067847 c.99C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067850 c.96A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.3 para-aminosalicylic_acid
thyX 3067874 c.70_72delCCCinsGG frameshift_variant&missense_variant 0.27 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067889 c.55_57delGCCinsCG frameshift_variant&synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067892 c.52_54delTTGinsCC frameshift_variant&missense_variant 0.21 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.21 para-aminosalicylic_acid
thyX 3067910 c.36C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067934 c.12C>A synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624377 c.534C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624389 c.522C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624396 p.Ala172Val missense_variant 0.23 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.21 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624431 c.480C>T synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624448 c.463C>T synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624455 c.456G>A synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624464 c.447A>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624637 p.His92Asn missense_variant 0.18 bedaquiline
rifampicin
lpqB 3624653 c.258C>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625095 p.Glu507Lys missense_variant 0.35 bedaquiline
rifampicin
lpqB 3625111 c.-201G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.42 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625141 c.-231T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625162 c.-252T>G upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625174 c.-264C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625177 c.-267C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625186 c.-276T>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625204 c.1408_1410delTCGinsGT frameshift_variant&missense_variant 0.37 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625222 c.1392T>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625240 c.-330T>G upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625243 c.-333T>G upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625251 c.-341C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625255 c.-345T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625263 p.Tyr451His missense_variant 0.24 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625273 c.-363C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625599 p.Met339Leu missense_variant 0.21 bedaquiline
rifampicin Uncertain significance
lpqB 3625612 c.-702G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625615 c.-705G>A upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ser missense_variant 0.25 bedaquiline
rifampicin
lpqB 3625624 c.-714C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625627 p.Asp329Glu missense_variant 0.25 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625636 p.Ala326Glu missense_variant 0.27 bedaquiline
rifampicin
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.28 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625654 c.958_960delTTGinsCC frameshift_variant&missense_variant 0.28 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625663 c.-753G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625675 c.-765G>T upstream_gene_variant 0.43 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625699 c.915C>T synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3625744 c.870G>A synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.49 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625795 c.-885G>C upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625801 c.-891G>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625819 c.795G>A synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625828 c.-918G>A upstream_gene_variant 0.51 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3625873 c.741C>T synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625882 c.-972G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625899 p.Val239Leu missense_variant 0.38 bedaquiline
rifampicin
lpqB 3625909 c.-999T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625912 c.702G>C synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3625920 c.694C>T synonymous_variant 0.3 bedaquiline
rifampicin
mtrB 3625921 c.693G>T synonymous_variant 0.29 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.672C>G synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3625945 c.669A>G synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3625951 c.663A>G synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626684 c.-71G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3626729 c.619_621delAAGinsCA frameshift_variant&missense_variant 0.3 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626735 c.-122C>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626750 c.-137T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626776 c.-163A>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626789 c.561C>T synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626804 c.-191A>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626816 c.-203G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3626822 p.Asp176Glu missense_variant 0.4 bedaquiline
rifampicin
mtrB 3626852 c.-239G>A upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626858 c.-245A>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626881 c.-268C>T upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626882 c.468G>C synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626885 c.-272A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626907 p.Asn148Ala missense_variant 0.35 bedaquiline
rifampicin
mtrA 3626909 c.441C>T synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3626913 p.Thr146Ser missense_variant 0.34 bedaquiline
rifampicin
mtrB 3626915 c.-302C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626933 c.-320C>T upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.35 bedaquiline
rifampicin
mtrA 3626942 c.406_408delGTAinsAC frameshift_variant&missense_variant 0.34 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626999 c.-386G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627017 c.-404G>A upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627071 c.-458G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627131 p.Ala73Lys missense_variant 0.42 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.42 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627213 p.Arg46His missense_variant 0.44 bedaquiline
rifampicin
mtrB 3627224 c.-611G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627247 p.Ile35Val missense_variant 0.36 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627272 c.-659G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
rpoA 3877548 c.960C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877553 p.Glu319Gln missense_variant 0.21 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.31 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.44 rifampicin
rpoA 3877611 c.895_897delATCinsGG frameshift_variant&missense_variant 0.47 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.48 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.53 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.56 rifampicin
rpoA 3877674 c.834C>G synonymous_variant 0.55 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 0.53 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.56 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.5 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.51 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.54 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.55 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.53 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.48 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.42 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.34 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.33 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.33 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.24 rifampicin
rpoA 3878013 c.495T>C synonymous_variant 0.22 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.18 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.23 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.25 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.34 rifampicin
rpoA 3878093 p.Val139Ile missense_variant 0.36 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.37 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.38 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.38 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.41 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.42 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.46 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.51 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.56 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878241 c.267G>A synonymous_variant 0.53 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.53 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.52 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.52 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.53 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.56 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.55 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.58 rifampicin
rpoA 3878304 c.204G>C synonymous_variant 0.58 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.59 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.56 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.53 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.49 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878403 c.105C>G synonymous_variant 0.47 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.43 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.38 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.3 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.27 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.2 rifampicin
rpoA 3878672 c.-165A>T upstream_gene_variant 0.27 rifampicin
rpoA 3878689 c.-182G>A upstream_gene_variant 0.31 rifampicin
rpoA 3878694 c.-187A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878701 c.-194C>T upstream_gene_variant 0.3 rifampicin
rpoA 3878704 c.-199_-197delGACinsCG upstream_gene_variant 0.31 rifampicin
rpoA 3878722 c.-215C>G upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878725 c.-220_-218delCTAinsTG upstream_gene_variant 0.32 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.39 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878758 c.-251G>C upstream_gene_variant 0.41 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.43 rifampicin
rpoA 3878767 c.-260G>A upstream_gene_variant 0.41 rifampicin
rpoA 3878775 c.-268A>G upstream_gene_variant 0.45 rifampicin Uncertain significance
rpoA 3878785 c.-278T>C upstream_gene_variant 0.48 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.49 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.52 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.5 rifampicin
rpoA 3878830 c.-325_-323delCTGinsAC upstream_gene_variant 0.5 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.5 rifampicin
rpoA 3878843 c.-337_-336delCGinsAA upstream_gene_variant 0.5 rifampicin
rpoA 3878845 c.-338G>C upstream_gene_variant 0.5 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.54 rifampicin
rpoA 3878873 c.-366G>A upstream_gene_variant 0.51 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.49 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.46 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.45 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.45 rifampicin
rpoA 3878899 c.-392C>G upstream_gene_variant 0.44 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.42 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.41 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.39 rifampicin
rpoA 3878947 c.-440G>T upstream_gene_variant 0.37 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878961 c.-454C>T upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878962 c.-455G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878977 c.-470C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.26 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.21 rifampicin
rpoA 3879019 c.-512T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879032 c.-528_-525delAGCCinsGG upstream_gene_variant 0.21 rifampicin
rpoA 3879037 c.-531_-530insCC upstream_gene_variant 0.21 rifampicin
rpoA 3879043 c.-536C>G upstream_gene_variant 0.24 rifampicin
rpoA 3879046 c.-539G>A upstream_gene_variant 0.26 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879097 c.-590C>T upstream_gene_variant 0.22 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.3 rifampicin
rpoA 3879125 c.-618T>G upstream_gene_variant 0.3 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.34 rifampicin
rpoA 3879178 c.-671T>G upstream_gene_variant 0.35 rifampicin
rpoA 3879190 c.-683C>A upstream_gene_variant 0.32 rifampicin
rpoA 3879199 c.-692C>T upstream_gene_variant 0.25 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.23 rifampicin
ddn 3986615 c.-229C>A upstream_gene_variant 0.46 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.39 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.36 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.34 delamanid
pretomanid
ddn 3986657 c.-187C>T upstream_gene_variant 0.3 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.28 delamanid
pretomanid
ddn 3986663 c.-180_-177delAGCC upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986673 c.-171C>T upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986696 c.-148G>C upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986699 c.-145C>G upstream_gene_variant 0.26 delamanid
pretomanid
clpC1 4038293 c.2412G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038310 p.Val799Leu missense_variant 0.21 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038335 c.2370C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038344 c.2361G>A synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038356 c.2349T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038380 c.2325C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.18 pyrazinamide
clpC1 4038530 c.2175G>A synonymous_variant 0.18 pyrazinamide
clpC1 4038535 p.Arg724Ser missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4038539 c.2166G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.44 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.47 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.52 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.53 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.58 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.58 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.57 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.57 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.59 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.6 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.59 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.6 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.59 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.58 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038824 c.1881C>T synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038875 c.1830C>G synonymous_variant 0.57 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.53 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.52 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.52 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.52 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.53 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.53 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.53 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038962 c.1743C>T synonymous_variant 0.52 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.45 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039037 c.1668T>G synonymous_variant 0.45 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.51 pyrazinamide
clpC1 4039139 c.1564_1566delGAGinsAC frameshift_variant&missense_variant 0.52 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039145 c.1560G>T synonymous_variant 0.53 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.56 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039243 c.1462C>T synonymous_variant 0.57 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.56 pyrazinamide
clpC1 4039286 c.1417_1419delCTTinsTG frameshift_variant&synonymous_variant 0.56 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.57 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.56 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.52 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.56 pyrazinamide
clpC1 4039394 c.1311G>T synonymous_variant 0.55 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.56 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039556 c.1149G>T synonymous_variant 0.49 pyrazinamide
clpC1 4039559 c.1146C>A synonymous_variant 0.47 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.46 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.45 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039582 p.Thr375Ser missense_variant 0.46 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039601 c.1104G>T synonymous_variant 0.52 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.44 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.44 pyrazinamide
clpC1 4039823 c.882T>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039934 c.771G>T synonymous_variant 0.44 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.47 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039991 c.714G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040001 p.His235Ala missense_variant 0.49 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.51 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.49 pyrazinamide
clpC1 4040048 c.657C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.52 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>G synonymous_variant 0.51 pyrazinamide
clpC1 4040135 c.570C>G synonymous_variant 0.49 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.46 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040165 c.540G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.49 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.49 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.5 pyrazinamide
clpC1 4040225 c.480A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040231 c.472_474delCGCinsAG frameshift_variant&missense_variant 0.5 pyrazinamide
clpC1 4040240 c.465C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.53 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.54 pyrazinamide
clpC1 4040273 c.432T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.52 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.55 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.54 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.51 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.47 pyrazinamide
clpC1 4040363 c.342A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040369 c.336C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.48 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.53 pyrazinamide
clpC1 4040437 c.268C>T synonymous_variant 0.53 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.51 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040513 c.192G>A synonymous_variant 0.53 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.54 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.54 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.54 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.54 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.53 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCT frameshift_variant&missense_variant 0.49 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.48 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040615 c.90C>T synonymous_variant 0.5 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.44 pyrazinamide
clpC1 4040645 c.60C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040660 c.45G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040669 c.36C>T synonymous_variant 0.39 pyrazinamide
clpC1 4040674 c.31A>C synonymous_variant 0.36 pyrazinamide
clpC1 4040681 c.24T>G synonymous_variant 0.34 pyrazinamide
clpC1 4040695 c.10C>A synonymous_variant 0.25 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.24 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.25 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
panD 4044147 c.135C>G synonymous_variant 0.33 pyrazinamide
panD 4044150 c.132A>G synonymous_variant 0.32 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
panD 4044162 c.120A>G synonymous_variant 0.33 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.33 pyrazinamide
panD 4044180 p.Asp34Glu missense_variant 0.32 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.32 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.32 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.33 pyrazinamide
panD 4044216 c.66C>T synonymous_variant 0.31 pyrazinamide
panD 4044232 p.Cys17His missense_variant 0.28 pyrazinamide
panD 4044246 c.36C>T synonymous_variant 0.29 pyrazinamide
panD 4044264 c.18G>C synonymous_variant 0.19 pyrazinamide
glpK 4138568 c.1188A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ala missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Thr missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 p.Ser346Val missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1030_1032delGCAinsAC frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138751 c.1005T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138754 c.1002C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.997_999delCTAinsTG frameshift_variant&synonymous_variant 0.27 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240723 c.861C>G synonymous_variant 0.18 ethambutol
embC 4240736 p.Ser292Thr missense_variant 0.18 ethambutol
embC 4240800 p.Tyr313Phe missense_variant 0.18 ethambutol
embC 4240819 c.957A>T synonymous_variant 0.18 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.19 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.21 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.2 ethambutol
embC 4241084 p.Leu408Ala missense_variant 0.26 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241129 c.1267C>T synonymous_variant 0.34 ethambutol
embC 4241135 p.Val425Leu missense_variant 0.33 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4241158 c.1296T>C synonymous_variant 0.28 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4241162 p.Leu434Met missense_variant 0.28 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.28 ethambutol
embC 4241168 c.1306C>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4241197 c.1335G>C synonymous_variant 0.28 ethambutol
embC 4241203 c.1341T>G synonymous_variant 0.28 ethambutol
embC 4241215 c.1353C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241738 p.Val626Leu missense_variant 1.0 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244705 c.1473G>C synonymous_variant 0.2 ethambutol
embA 4244726 p.Asp498Glu missense_variant 0.19 ethambutol
embA 4244747 c.1515T>G synonymous_variant 0.22 ethambutol
embA 4244753 c.1521G>C synonymous_variant 0.2 ethambutol
embA 4244757 p.Ser509Asp missense_variant 0.2 ethambutol
embA 4244765 c.1533T>C synonymous_variant 0.2 ethambutol
embA 4244768 p.Glu512Asp missense_variant 0.2 ethambutol
embA 4244770 p.Gly513Ala missense_variant 0.2 ethambutol
embA 4244778 p.Ser516Thr missense_variant 0.2 ethambutol
embA 4244792 c.1560G>C synonymous_variant 0.29 ethambutol
embA 4244802 c.1570T>C synonymous_variant 0.32 ethambutol
embA 4244814 p.Leu528Met missense_variant 0.31 ethambutol
embA 4244821 p.Gly530Ala missense_variant 0.26 ethambutol
embA 4244823 p.Val531Met missense_variant 0.25 ethambutol
embA 4244829 c.1597_1599delTTCinsGG frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
embA 4244849 c.1617C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embA 4244853 c.1621_1623delGTGinsAC frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
embA 4244856 c.1624_1626delGCGinsAC frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
embA 4244862 p.Leu544Val missense_variant 0.26 ethambutol
embA 4244885 c.1653A>G synonymous_variant 0.24 ethambutol
embA 4244895 c.1663_1665delACTinsTG frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
embA 4244900 c.1668G>C synonymous_variant 0.25 ethambutol
embA 4244906 c.1674C>G synonymous_variant 0.25 ethambutol
embA 4244913 c.1681_1683delCTGinsTA frameshift_variant&stop_gained 0.25 ethambutol Uncertain significance
embA 4244921 c.1689C>G synonymous_variant 0.27 ethambutol
embA 4244930 c.1698G>C synonymous_variant 0.26 ethambutol
embA 4244933 c.1701A>G synonymous_variant 0.24 ethambutol
embA 4244945 c.1713C>G synonymous_variant 0.18 ethambutol
embB 4247462 c.949_950delTCinsAG synonymous_variant 0.23 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.29 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.31 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.31 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.31 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.32 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.36 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.37 ethambutol
embB 4247543 c.1030_1031delAGinsTC synonymous_variant 0.34 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.3 ethambutol
embB 4247555 c.1042_1044delCTGinsAC frameshift_variant&missense_variant 0.3 ethambutol
embB 4247563 p.Met350Ile missense_variant 0.31 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.31 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.36 ethambutol
embB 4247576 c.1063C>T synonymous_variant 0.36 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4247611 c.1098G>C synonymous_variant 0.35 ethambutol
embB 4247614 c.1101T>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4247626 c.1113C>G synonymous_variant 0.3 ethambutol
embB 4247629 c.1116C>G synonymous_variant 0.29 ethambutol
embB 4247630 p.Leu373Phe missense_variant 0.29 ethambutol
embB 4247635 c.1122G>C synonymous_variant 0.28 ethambutol
embB 4247638 c.1125G>C synonymous_variant 0.28 ethambutol
embB 4247646 p.Glu378Ala missense_variant 0.29 ethambutol Not assoc w R
embB 4247656 c.1143A>G synonymous_variant 0.28 ethambutol
embB 4247662 c.1149C>G synonymous_variant 0.24 ethambutol
embB 4247663 p.Tyr384Leu missense_variant 0.24 ethambutol
embB 4247674 c.1161G>C synonymous_variant 0.23 ethambutol
embB 4247683 c.1170C>G synonymous_variant 0.24 ethambutol
embB 4247684 c.1171T>C synonymous_variant 0.23 ethambutol
embB 4247690 p.Thr393Ala missense_variant 0.24 ethambutol
embB 4247695 c.1182G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247957 p.Met482Leu missense_variant 0.18 ethambutol
embB 4247972 c.1459_1461delACCinsGG frameshift_variant&missense_variant 0.22 ethambutol
embB 4247977 c.1464C>G synonymous_variant 0.22 ethambutol
embB 4247992 c.1479G>C synonymous_variant 0.23 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.19 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.2 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.19 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.25 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.24 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.24 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.29 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.27 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.26 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.26 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.26 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.26 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.26 ethambutol
embB 4248149 p.Thr546Cys missense_variant 0.27 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4248173 p.Val554Met missense_variant 0.35 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.3 ethambutol
embB 4248202 c.1689T>C synonymous_variant 0.29 ethambutol
embB 4248203 p.Pro564Ala missense_variant 0.28 ethambutol
embB 4248206 c.1693_1695delAGCinsGA frameshift_variant&missense_variant 0.28 ethambutol
embB 4248215 p.Arg568Ser missense_variant 0.3 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.3 ethambutol
embB 4248225 p.Ala571Val missense_variant 0.31 ethambutol Uncertain significance
embB 4248248 c.1735_1737delTTCinsCG frameshift_variant&missense_variant 0.21 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.21 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.21 ethambutol
embB 4248264 p.Phe584Ser missense_variant 0.22 ethambutol
embB 4248274 c.1761C>T synonymous_variant 0.22 ethambutol
embB 4248275 c.1762_1764delACGinsGC frameshift_variant&missense_variant 0.22 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338599 c.-78A>C upstream_gene_variant 1.0 capreomycin
amikacin Uncertain significance
kanamycin
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R