TB-Profiler result

Run: ERR4800341

Summary

Run ID: ERR4800341

Sample name:

Date: 2024-03-25T23:09:52.875524

Number of reads: 1536481

Percentage reads mapped: 48.13

Median coverage: 49.0

Strain: lineage3

Spoligotype:

Drug-resistance: HR-TB


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.78
La1.2.BCG M.bovis None 0.11
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.298_300delCCGinsGA Assoc w R High-level resistance
ethambutol embB p.His312Arg Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.202_204delCTGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.718_720delGAGinsAA Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 490984 c.202_204delCTGinsAC frameshift_variant&missense_variant 0.33 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.52 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.36 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491500 c.718_720delGAGinsAA frameshift_variant&missense_variant 0.24 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.59 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.37 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.45 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance Mutation from literature
katG 2155812 c.298_300delCCGinsGA frameshift_variant&missense_variant 0.27 isoniazid Assoc w R High-level resistance
embB 4247448 p.His312Arg missense_variant 0.57 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.28 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 510 c.510T>C synonymous_variant 0.22 isoniazid
dnaA 534 c.534T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>C synonymous_variant 0.37 isoniazid
dnaA 561 c.561C>T synonymous_variant 0.37 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.36 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.34 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.36 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.36 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.37 isoniazid
dnaA 597 c.597C>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>A synonymous_variant 0.45 isoniazid
dnaA 612 c.612G>C synonymous_variant 0.52 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.56 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.63 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.61 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.61 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.62 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.65 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.67 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.63 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.62 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.58 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.57 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.58 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.55 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.48 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.47 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.42 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.41 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.39 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.4 isoniazid Uncertain significance
dnaA 813 c.813C>T synonymous_variant 0.39 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.36 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.36 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.38 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.46 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.43 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.43 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.45 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.42 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.42 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.46 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.53 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.57 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.59 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.61 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.65 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.65 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.62 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.57 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.56 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.56 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.55 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.57 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.58 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.49 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.49 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.51 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.52 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.56 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.57 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.58 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.61 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.59 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.59 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.58 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.58 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.56 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.5 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.47 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.52 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 0.49 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.49 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.54 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.56 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.56 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.56 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.58 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.54 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.49 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.48 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.48 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.46 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.46 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.46 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.46 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.46 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.47 isoniazid Not assoc w R - Interim
dnaA 1332 c.1332A>C synonymous_variant 0.51 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.52 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.53 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.57 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.57 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.57 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.54 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.54 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.52 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.51 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.51 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.54 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.56 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.6 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.63 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.6 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.51 isoniazid
dnaA 1485 c.1485A>G synonymous_variant 0.4 isoniazid
dnaA 1488 c.1488A>G synonymous_variant 0.35 isoniazid
dnaA 1497 c.1497T>C synonymous_variant 0.28 isoniazid
gyrB 5809 c.570C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.65 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6580 c.-722C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6598 c.-704C>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.71 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.66 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.62 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.61 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>A upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642_1644delTTGinsCC frameshift_variant&missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7228 c.-74C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7246 c.2007T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7307 c.6A>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7313 c.12G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7317 c.16T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7324 c.23_24insAGG disruptive_inframe_insertion 0.38 levofloxacin
moxifloxacin
gyrA 7334 c.33G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7335 p.Leu12Val missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 7347 c.46_48delGAAinsCG frameshift_variant&missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.63 levofloxacin
moxifloxacin
gyrA 7691 c.390C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7694 c.393A>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.63 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.46 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 c.1099_1101delGACinsAT frameshift_variant&missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.47 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.36 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.39 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9278 c.1977G>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9386 c.2085T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9389 c.2088C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9413 c.2112G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
Rv0010c 13876 c.-318G>C upstream_gene_variant 0.23 isoniazid
Rv0010c 13879 c.-321T>C upstream_gene_variant 0.22 isoniazid
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.23 isoniazid
Rv0010c 13897 c.-339C>T upstream_gene_variant 0.24 isoniazid
fgd1 490905 c.123T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 490977 c.195C>G synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 490980 p.Asn66Lys missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490983 c.201G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490987 p.Leu69Thr missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491001 c.219G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491067 c.285C>T synonymous_variant 0.47 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491077 p.Asn99Gly missense_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.4 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491487 c.705C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491523 c.741G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491607 c.825G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491697 c.915G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491712 c.930T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491718 c.936A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491721 c.939A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491724 c.942A>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491727 c.945T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575063 c.-285T>C upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 575075 c.-273T>C upstream_gene_variant 0.23 ethionamide
isoniazid Uncertain significance
mshA 575084 c.-264T>C upstream_gene_variant 0.28 ethionamide
isoniazid
mshA 575576 c.229C>T synonymous_variant 0.23 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575581 c.234C>T synonymous_variant 0.22 ethionamide
isoniazid
mshA 575587 c.240C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575629 c.282A>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575632 c.285G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.29 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575662 c.315C>G synonymous_variant 0.46 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.51 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.49 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.48 ethionamide
isoniazid
mshA 575704 c.357T>G synonymous_variant 0.5 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.62 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.62 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.65 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.64 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.63 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.62 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.62 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.6 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.6 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.61 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.62 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.57 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.55 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.56 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.56 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.55 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.53 ethionamide
isoniazid Not assoc w R - Interim
mshA 575864 c.517T>C synonymous_variant 0.51 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.43 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.41 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.4 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.39 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575965 c.618C>G synonymous_variant 0.27 ethionamide
isoniazid Not assoc w R - Interim
mshA 576184 c.837A>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 576233 p.Ile296Val missense_variant 0.23 ethionamide
isoniazid
mshA 576241 c.894C>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 576262 c.915T>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 576271 c.924A>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 576281 c.934C>T synonymous_variant 0.28 ethionamide
isoniazid Not assoc w R - Interim
mshA 576285 p.Val313Ala missense_variant 0.3 ethionamide
isoniazid
mshA 576289 c.942G>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 576292 c.945C>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 576301 c.954A>G synonymous_variant 0.3 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 619668 c.-223_-222delCGinsGC upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>T upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619676 c.-215C>G upstream_gene_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620298 c.408G>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.42 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620424 c.534G>C synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.41 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620442 c.552G>C synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620659 c.769_771delCGCinsAG frameshift_variant&missense_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.61 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.49 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620809 c.919C>T synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620823 c.933C>T synonymous_variant 0.39 capreomycin
amikacin
kanamycin
Rv0565c 656219 p.His418Tyr missense_variant 0.28 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.28 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.27 ethionamide Not assoc w R - Interim
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.27 ethionamide Uncertain significance
Rv0565c 656238 p.Ala411Glu missense_variant 0.26 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.26 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.27 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.31 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.32 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.36 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.33 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.33 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.31 ethionamide
Rv0565c 656325 c.1146C>G synonymous_variant 0.25 ethionamide
Rv0565c 656383 p.Val363Asn missense_variant 0.23 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.33 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.33 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.36 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.39 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.4 ethionamide
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.4 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.4 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.4 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.43 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.48 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.44 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.44 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.5 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.51 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.54 ethionamide Not assoc w R - Interim
Rv0565c 656526 p.Glu315Asp missense_variant 0.58 ethionamide
Rv0565c 656535 c.936C>G synonymous_variant 0.52 ethionamide
Rv0565c 656539 p.Ser311Ala missense_variant 0.48 ethionamide
Rv0565c 656542 p.Thr310Ser missense_variant 0.46 ethionamide
Rv0565c 656550 c.919_921delAACinsGG frameshift_variant&missense_variant 0.46 ethionamide Uncertain significance
Rv0565c 656568 c.903G>C synonymous_variant 0.37 ethionamide
Rv0565c 656582 p.Leu297Met missense_variant 0.33 ethionamide
Rv0565c 656583 c.888A>G synonymous_variant 0.31 ethionamide
Rv0565c 656589 c.882T>C synonymous_variant 0.34 ethionamide
Rv0565c 656595 c.876G>C synonymous_variant 0.34 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 0.94 ethionamide Not assoc w R - Interim
Rv0565c 657138 c.331_333delGCAinsTG frameshift_variant&missense_variant 0.24 ethionamide Uncertain significance
Rv0565c 657144 c.327T>G synonymous_variant 0.27 ethionamide
Rv0565c 657155 p.Asn106Asp missense_variant 0.32 ethionamide
Rv0565c 657160 p.Glu104Arg missense_variant 0.31 ethionamide
Rv0565c 657171 c.300T>C synonymous_variant 0.3 ethionamide
Rv0565c 657187 p.His95Arg missense_variant 0.29 ethionamide
Rv0565c 657189 c.282C>G synonymous_variant 0.29 ethionamide
Rv0565c 657192 p.Met93Thr missense_variant 0.29 ethionamide
Rv0565c 657196 p.Asp92Ala missense_variant 0.29 ethionamide
Rv0565c 657200 p.Thr91Ala missense_variant 0.29 ethionamide Uncertain significance
Rv0565c 657201 c.270C>G synonymous_variant 0.29 ethionamide
Rv0565c 657219 p.Ala84Val missense_variant 0.33 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.5 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.5 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.49 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.49 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.52 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.49 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.53 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.53 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.52 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.53 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.52 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.51 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.51 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.51 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.51 ethionamide
Rv0565c 657372 c.99G>C synonymous_variant 0.29 ethionamide
Rv0565c 657375 c.96C>T synonymous_variant 0.25 ethionamide
Rv0565c 657385 p.Ile29Thr missense_variant 0.24 ethionamide
Rv0565c 657563 c.-93T>C upstream_gene_variant 0.3 ethionamide
Rv0565c 657571 c.-101T>C upstream_gene_variant 0.35 ethionamide
Rv0565c 657572 c.-102A>G upstream_gene_variant 0.35 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.44 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.4 ethionamide
Rv0565c 657600 c.-132_-131delCA upstream_gene_variant 0.39 ethionamide
Rv0565c 657606 c.-136T>G upstream_gene_variant 0.35 ethionamide
Rv0565c 657607 c.-138_-137insCA upstream_gene_variant 0.37 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.47 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.43 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.49 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.47 ethionamide
Rv0565c 657680 c.-210G>C upstream_gene_variant 0.49 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.5 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.53 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.4 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.35 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.32 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.33 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.33 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.36 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.34 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.38 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.5 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.53 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.51 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.43 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.41 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.4 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.39 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.35 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.34 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.36 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.38 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.38 isoniazid
hadA 732238 c.309G>C synonymous_variant 0.24 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.33 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.33 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.32 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.32 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.32 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.61 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.62 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.62 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.64 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.71 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.76 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.73 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.77 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.77 isoniazid
nusG 734370 c.117A>G synonymous_variant 0.3 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.33 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.43 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.44 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.43 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.54 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.54 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.57 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.53 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.52 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.52 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.53 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.5 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.47 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.4 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.32 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.32 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.29 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.28 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.26 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.29 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.28 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.25 rifampicin
nusG 734664 c.411T>G synonymous_variant 0.23 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.26 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.25 rifampicin
nusG 734772 c.519G>C synonymous_variant 0.28 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.27 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.26 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.28 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.29 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.28 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.34 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.38 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.26 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.23 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 0.86 rifampicin Not assoc w R
rpoB 760046 c.240G>C synonymous_variant 0.26 rifampicin
rpoB 760060 p.Tyr85Leu missense_variant 0.29 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.29 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.31 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.47 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.57 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.58 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.56 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.57 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.58 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.56 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.57 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.52 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.55 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.56 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.65 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.65 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.74 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.75 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.8 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.68 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.63 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.59 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.52 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.52 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.48 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.48 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.48 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.43 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.6 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.62 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.62 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.8 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.87 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.81 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.75 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.78 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.77 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.76 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.73 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.65 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.59 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.55 rifampicin
rpoB 761373 p.Val523His missense_variant 0.51 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.52 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.44 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.4 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.38 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.38 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.39 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.39 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.39 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.45 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.55 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.58 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.55 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.57 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.65 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.6 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.51 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.56 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.5 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.5 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.5 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.52 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.54 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.56 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.57 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.57 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.59 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.58 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.55 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.56 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.57 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.53 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.52 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.54 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.56 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.57 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.56 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.56 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.58 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.59 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.59 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.62 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.69 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.71 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.69 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.71 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.76 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.73 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.71 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.65 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.64 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.57 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.52 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.52 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.53 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.53 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.47 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.46 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.53 rifampicin
rpoB 762413 c.2607G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.56 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.57 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.41 rifampicin Not assoc w R
rpoB 762449 c.2643C>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.48 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.43 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.38 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.4 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.32 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.37 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.35 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.34 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.34 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.34 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.34 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.62 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.59 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.42 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.57 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.53 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.41 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.33 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.36 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.6 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.75 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.65 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.68 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.69 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.65 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.65 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.67 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.6 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.62 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.59 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.57 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.56 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.49 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.45 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.45 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.46 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.44 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.44 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.49 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.52 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.47 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.47 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.49 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.47 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.43 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.37 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.43 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.49 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.58 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.55 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.55 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.58 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.52 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.53 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.51 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.55 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.49 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.46 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.49 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.45 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.48 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.59 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.65 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.7 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.67 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.75 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.65 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.65 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.68 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.68 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.7 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.73 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.71 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.66 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.59 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.52 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.4 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.39 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.37 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.47 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.47 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.54 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.6 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.66 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.68 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.7 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.66 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.64 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.64 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.67 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.66 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.69 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.68 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.6 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.6 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.64 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.59 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.58 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.55 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.57 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.65 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.64 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.72 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.69 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.66 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.69 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.68 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.68 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.68 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.62 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.59 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.58 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.51 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.45 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.49 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.4 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.39 rifampicin
rpoC 766185 p.Glu939Ala missense_variant 0.31 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.34 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.4 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.4 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.43 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.48 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.55 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.59 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.59 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.62 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.63 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.69 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.69 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.73 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.71 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.7 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.72 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.7 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.68 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.68 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.66 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.59 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.59 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.59 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.55 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.53 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.53 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.47 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.47 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.5 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.56 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.58 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.72 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.68 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.67 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.67 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.68 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.6 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.57 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.6 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.59 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.65 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.64 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.63 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.63 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.62 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.64 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.63 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.59 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.54 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775901 c.2580G>A synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.31 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775921 c.2560C>T synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 775943 c.2538C>G synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.37 clofazimine
bedaquiline
mmpL5 775973 c.2506_2508delTTGinsCC frameshift_variant&missense_variant 0.37 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775981 p.Leu834Met missense_variant 0.42 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.39 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.4 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776005 p.Ile826Leu missense_variant 0.38 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.49 clofazimine
bedaquiline
mmpL5 776030 c.2451G>A synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 776036 c.2445G>C synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777133 p.Val450Ile missense_variant 0.3 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777173 c.1308C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.29 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777212 c.1267_1269delGCCinsAG frameshift_variant&missense_variant 0.26 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777215 c.1266C>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.26 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.21 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.33 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.29 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.3 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.45 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.44 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.48 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.49 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.54 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.53 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.54 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.55 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.58 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.57 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.59 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.59 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.62 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.66 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.62 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.68 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.68 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.68 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.68 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.7 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.65 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.62 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.63 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.65 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.64 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.62 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.62 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.63 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.42 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.51 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.53 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.58 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.57 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.58 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.55 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.57 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.56 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.61 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.59 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.58 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.59 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.61 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.62 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.61 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.59 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.62 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.48 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.48 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.49 linezolid
rplC 800814 c.6A>G synonymous_variant 0.46 linezolid
rplC 800817 c.9A>T synonymous_variant 0.45 linezolid
rplC 800844 c.36T>C synonymous_variant 0.5 linezolid
rplC 800865 c.57A>G synonymous_variant 0.45 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.45 linezolid
rplC 800874 c.66A>G synonymous_variant 0.41 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.4 linezolid
rplC 800880 c.72A>G synonymous_variant 0.41 linezolid
rplC 800889 c.81C>G synonymous_variant 0.45 linezolid
rplC 800892 c.84G>C synonymous_variant 0.44 linezolid
rplC 800907 c.99C>G synonymous_variant 0.44 linezolid
rplC 800916 c.108A>G synonymous_variant 0.38 linezolid
rplC 800934 c.126C>G synonymous_variant 0.29 linezolid
rplC 800937 c.129A>G synonymous_variant 0.29 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.29 linezolid
rplC 800946 c.138T>C synonymous_variant 0.28 linezolid
rplC 800949 c.141T>C synonymous_variant 0.28 linezolid
rplC 800967 c.159C>G synonymous_variant 0.28 linezolid
rplC 800970 c.162T>C synonymous_variant 0.26 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.21 linezolid
rplC 801195 c.387G>C synonymous_variant 0.34 linezolid
rplC 801201 c.393C>T synonymous_variant 0.34 linezolid
rplC 801207 c.399C>T synonymous_variant 0.36 linezolid
rplC 801246 c.438C>T synonymous_variant 0.48 linezolid
rplC 801249 c.441T>C synonymous_variant 0.49 linezolid
rplC 801255 c.447C>T synonymous_variant 0.49 linezolid
rplC 801264 c.456C>T synonymous_variant 0.46 linezolid
rplC 801267 c.459A>T synonymous_variant 0.46 linezolid
rplC 801270 c.462T>C synonymous_variant 0.45 linezolid
rplC 801276 c.468G>C synonymous_variant 0.45 linezolid
rplC 801279 c.471G>C synonymous_variant 0.44 linezolid
rplC 801282 c.474G>C synonymous_variant 0.44 linezolid
rplC 801285 c.477G>C synonymous_variant 0.43 linezolid
rplC 801300 c.492C>G synonymous_variant 0.52 linezolid
rplC 801309 c.501C>G synonymous_variant 0.51 linezolid
rplC 801312 c.504G>C synonymous_variant 0.5 linezolid
rplC 801321 c.513C>T synonymous_variant 0.52 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.51 linezolid
rplC 801339 c.531T>C synonymous_variant 0.41 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.41 linezolid
rplC 801348 c.540T>G synonymous_variant 0.41 linezolid
rplC 801357 c.549T>C synonymous_variant 0.44 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.41 linezolid
rplC 801402 c.594T>C synonymous_variant 0.36 linezolid
rplC 801405 c.597T>C synonymous_variant 0.39 linezolid
rplC 801423 c.615G>C synonymous_variant 0.36 linezolid
rplC 801426 c.618C>G synonymous_variant 0.35 linezolid
rplC 801427 p.Met207Val missense_variant 0.37 linezolid
rplC 801438 c.630T>C synonymous_variant 0.36 linezolid
rplC 801442 p.Ile212Val missense_variant 0.42 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303441 c.511T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303455 c.525C>G synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303476 c.546G>C synonymous_variant 0.45 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303489 c.559C>T synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303497 c.567G>A synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304106 c.1176G>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ser missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304208 c.1278C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.56 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.53 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305081 c.2151G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305156 c.2226G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305210 c.2280G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305215 p.Ser762Thr missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305234 c.2304G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305309 c.2379G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305372 c.2442G>A synonymous_variant 0.25 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305384 c.2454G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305396 c.2466C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
sigE 1364691 c.279T>C synonymous_variant 0.24 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.31 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.31 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.32 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.33 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.3 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.25 pyrazinamide
sigE 1364751 c.339C>G synonymous_variant 0.25 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.29 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.29 pyrazinamide
sigE 1364772 c.360G>C synonymous_variant 0.29 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.37 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.35 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.37 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.38 pyrazinamide
sigE 1364839 c.427_429delTTGinsCC frameshift_variant&missense_variant 0.27 pyrazinamide Uncertain significance
sigE 1364847 c.435G>C synonymous_variant 0.27 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.26 pyrazinamide
sigE 1364862 c.450C>A synonymous_variant 0.26 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.26 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.26 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.25 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.21 pyrazinamide
sigE 1364943 c.531C>T synonymous_variant 0.21 pyrazinamide
sigE 1365057 c.645C>T synonymous_variant 0.19 pyrazinamide
atpE 1460816 c.-229T>C upstream_gene_variant 0.41 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.44 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.44 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.41 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.4 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.35 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.35 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.39 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.38 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.35 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.38 bedaquiline
atpE 1460915 c.-130C>G upstream_gene_variant 0.31 bedaquiline
atpE 1460918 c.-127A>G upstream_gene_variant 0.31 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.41 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.46 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.47 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.46 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.46 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.47 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.47 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.49 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.49 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.48 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.48 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.39 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473938 n.281G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1473939 n.282C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324G>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.58