TB-Profiler result

Run: ERR4831545
Summary

Run ID: ERR4831545

Sample name:

Date: 2024-03-26T18:38:01.494458

Number of reads: 1972358

Percentage reads mapped: 54.52

Median coverage: 61.0

Strain: M.canetti;lineage2.2

Spoligotype:

Drug-resistance: XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
La1.2.BCG M.bovis None 0.1
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
M.canetti M.canetti None 0.08
lineage4.6.2.1 Euro-American RD726 0.1
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
isoniazid inhA c.-779G>T Assoc w R - Interim Alias fabG1_c.-17G>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
c.346_348delCACinsTT Assoc w R High-level resistance
ethambutol embB p.Met306Ile Assoc w R
p.His312Arg Mutation from literature
pyrazinamide pncA c.517dupG Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
n.514A>C Assoc w R
gid p.Leu79Ser Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin rrs n.1401A>G Assoc w R
capreomycin rrs n.1401A>G Assoc w R
tlyA c.4_6delGCAinsTT Assoc w R
c.31_33delCTAinsTG Assoc w R
kanamycin rrs n.1401A>G Assoc w R
cycloserine alr p.Leu113Arg Mutation from literature
ethionamide inhA c.-779G>T Assoc w R - Interim Alias fabG1_c.-17G>T
ethA p.Ala381Pro Uncertain significance Mutation from literature
clofazimine pepQ c.594_595insCG Assoc w R - Interim
c.588_589delCG Assoc w R - Interim
c.562_564delGTGinsAC Assoc w R - Interim
c.418_420delCTGinsGC Assoc w R - Interim
para-aminosalicylic_acid
delamanid fgd1 c.796_798delATCinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.991_993delATCinsGT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiB c.1243_1245delCCAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.594_595insCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.588_589delCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.562_564delGTGinsAC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.418_420delCTGinsGC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 0.67 moxifloxacin Assoc w R High-level resistance
levofloxacin Assoc w R
fgd1 491578 c.796_798delATCinsCG frameshift_variant&missense_variant 0.26 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761110 p.Asp435Val missense_variant 0.41 rifampicin Assoc w R
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.34 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303921 c.991_993delATCinsGT frameshift_variant&missense_variant 0.28 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.25 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance Mutation from literature
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 0.31 streptomycin Assoc w R
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.41 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
inhA 1673423 c.-779G>T upstream_gene_variant 1.0 isoniazid Assoc w R - Interim Alias fabG1_c.-17G>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethionamide Assoc w R - Interim Alias fabG1_c.-17G>T
tlyA 1917943 c.4_6delGCAinsTT frameshift_variant&missense_variant 0.19 capreomycin Assoc w R
tlyA 1917970 c.31_33delCTAinsTG frameshift_variant&stop_gained 0.24 capreomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 0.98 isoniazid Assoc w R High-level resistance
katG 2155764 c.346_348delCACinsTT frameshift_variant&missense_variant 0.28 isoniazid Assoc w R High-level resistance
pncA 2288724 c.517dupG frameshift_variant 0.98 pyrazinamide Assoc w R
pepQ 2859824 c.594_595insCG frameshift_variant 0.32 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859829 c.588_589delCG frameshift_variant 0.29 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859855 c.562_564delGTGinsAC frameshift_variant&missense_variant 0.24 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859999 c.418_420delCTGinsGC frameshift_variant&missense_variant 0.2 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
fbiB 3642777 c.1243_1245delCCAinsGG frameshift_variant&missense_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
alr 3841083 p.Leu113Arg missense_variant 0.8 cycloserine Mutation from literature
embB 4247431 p.Met306Ile missense_variant 0.65 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.36 ethambutol Mutation from literature
ethA 4326333 p.Ala381Pro missense_variant 0.98 ethionamide Uncertain significance Mutation from literature
gid 4407967 p.Leu79Ser missense_variant 0.91 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 597 c.597C>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 609 c.609C>G synonymous_variant 0.22 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.22 isoniazid
dnaA 624 c.624C>T synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 627 c.627G>A synonymous_variant 0.29 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.29 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 652 c.652_654delCTAinsTG frameshift_variant&stop_gained 0.21 isoniazid Uncertain significance
dnaA 660 c.660G>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.21 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.22 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 675 c.675C>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 690 c.690G>C synonymous_variant 0.22 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 741 c.741T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>T synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 756 c.756T>C synonymous_variant 0.23 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.22 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.22 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.23 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.27 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.29 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.28 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.27 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.27 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.25 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.24 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.23 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.23 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1047 c.1047A>G synonymous_variant 0.21 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.22 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.25 isoniazid
dnaA 1080 c.1080C>G synonymous_variant 0.27 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.34 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.39 isoniazid
dnaA 1110 c.1110T>A synonymous_variant 0.41 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.42 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.42 isoniazid
dnaA 1134 c.1134G>T synonymous_variant 0.46 isoniazid
dnaA 1137 c.1137C>T synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 1140 c.1140C>G synonymous_variant 0.46 isoniazid
dnaA 1149 c.1149C>G synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.46 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.48 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.47 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.47 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.45 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 1203 c.1203T>C synonymous_variant 0.43 isoniazid
dnaA 1215 c.1215C>T synonymous_variant 0.43 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.42 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.42 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.4 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>G synonymous_variant 0.38 isoniazid
dnaA 1275 c.1275C>T synonymous_variant 0.33 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.32 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.3 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.3 isoniazid
dnaA 1296 c.1296C>G synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1299 c.1299G>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1314 c.1314A>G synonymous_variant 0.3 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.29 isoniazid
dnaA 1329 c.1329A>G synonymous_variant 0.3 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.3 isoniazid
dnaA 1341 c.1341G>C synonymous_variant 0.32 isoniazid
dnaA 1347 c.1347C>T synonymous_variant 0.3 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.35 isoniazid
dnaA 1356 c.1356T>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 1371 c.1371T>C synonymous_variant 0.35 isoniazid
dnaA 1374 c.1374G>A synonymous_variant 0.33 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.34 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.35 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.35 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.34 isoniazid
dnaA 1395 c.1395G>A synonymous_variant 0.34 isoniazid
dnaA 1401 c.1401C>T synonymous_variant 0.34 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.34 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.34 isoniazid
dnaA 1425 c.1425C>T synonymous_variant 0.35 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.35 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.36 isoniazid
dnaA 1441 c.1441C>T synonymous_variant 0.33 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.28 isoniazid
dnaA 1485 c.1485A>G synonymous_variant 0.31 isoniazid
gyrB 6166 c.927C>T synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6181 c.942C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.54 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.51 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.51 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>T upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6334 c.-968G>T upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6385 c.-917G>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6430 c.-872A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6440 c.1201_1203delACCinsGG frameshift_variant&missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin
gyrA 6448 c.-854G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6451 c.-851A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6457 c.-845T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6565 c.-737G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6583 c.-719G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6586 c.-716T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>T synonymous_variant 0.22 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6745 c.1506T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6763 c.-539G>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6764 c.-538C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6784 c.-518C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.32 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Thr missense_variant 0.32 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.41 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 6878 c.1639_1641delTTGinsCA frameshift_variant&missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin
gyrB 6881 c.1642T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6940 c.-362G>A upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6966 p.Ser576Thr missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6970 p.Asp577Glu missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7057 c.-245C>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 7136 c.1897_1899delTTGinsCT frameshift_variant&synonymous_variant 0.24 levofloxacin Uncertain significance
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7204 c.-98C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7778 c.477G>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7811 c.510C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8096 c.795T>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8126 c.825G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8129 c.828T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8141 c.840C>T synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8156 c.855T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8201 c.900C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8235 c.934T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 p.Asp415Glu missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8570 p.Glu423Asp missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8579 p.Asp426Glu missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8628 c.1327C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8681 c.1380C>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8690 c.1389C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8769 p.His490Tyr missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8834 c.1533C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8894 c.1593C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8906 c.1605C>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8918 c.1617C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.51 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.51 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9026 c.1725G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.4 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9065 c.1764C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9066 c.1765C>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9086 c.1785C>T synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9089 c.1788G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.34 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9164 c.1863G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9179 c.1878C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9208 p.Lys636Arg missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9242 c.1941A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9251 c.1950G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9254 c.1953C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9281 c.1980C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9335 c.2034G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
fgd1 490797 c.15G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490818 c.36C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 490947 c.165G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490971 c.189A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490980 p.Asn66Lys missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490981 c.199C>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490987 p.Leu69Val missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491055 c.273C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491058 c.276C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491491 p.Pro237Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491503 p.Leu241Lys missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491560 p.His260Thr missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491568 c.786C>T synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491569 p.Asp263His missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491625 c.843C>G synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491646 c.864G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491697 c.915G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574712 c.-636A>G upstream_gene_variant 0.23 ethionamide
isoniazid
mshA 574718 c.-630A>G upstream_gene_variant 0.25 ethionamide
isoniazid
mshA 574731 c.-617A>G upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 574739 c.-609T>C upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 575560 c.213C>T synonymous_variant 0.2 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.2 ethionamide
isoniazid
mshA 575576 c.229C>T synonymous_variant 0.25 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575587 c.240C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575590 c.243T>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575617 c.270C>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575620 c.273G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575629 c.282A>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.27 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.26 ethionamide
isoniazid
mshA 575653 c.306G>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575683 c.336G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575692 c.345G>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.37 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.42 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.47 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.49 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.48 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.51 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.52 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.51 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.46 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.44 ethionamide
isoniazid
mshA 575816 c.469C>T synonymous_variant 0.41 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.41 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575837 c.490C>T synonymous_variant 0.39 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575845 c.498C>G synonymous_variant 0.42 ethionamide
isoniazid
mshA 575848 c.501C>T synonymous_variant 0.44 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575914 c.567C>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575915 c.568_570delGACinsCG frameshift_variant&missense_variant 0.24 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575920 c.573C>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575947 c.600G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575953 c.606G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575984 c.637T>C synonymous_variant 0.23 ethionamide
isoniazid
ccsA 619555 c.-336C>T upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619558 c.-333G>C upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>T upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>C upstream_gene_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 619618 c.-273C>A upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620198 p.Gln103Leu missense_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620208 c.318G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620271 c.381C>G synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620291 p.Tyr134Phe missense_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620298 c.408G>A synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620370 c.480C>G synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>A synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620697 c.807C>T synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAT frameshift_variant&missense_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620724 c.834C>T synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>T synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAG frameshift_variant&missense_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>A synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620809 c.919C>T synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620829 c.939G>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620832 c.942C>T synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620835 c.945C>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620844 c.954C>T synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620847 c.957G>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.9 ethionamide Uncertain significance
Rv0565c 657300 c.171C>G synonymous_variant 0.21 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.25 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.24 ethionamide
Rv0565c 657700 c.-230A>G upstream_gene_variant 0.29 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.29 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.38 ethionamide
hadA 731690 c.-240_-237delAGACinsCAGTTTTTTTGAAGAA upstream_gene_variant 0.28 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.27 isoniazid
hadA 731708 c.-221_-220delGA upstream_gene_variant 0.31 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.43 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.44 isoniazid
hadA 731748 c.-182T>C upstream_gene_variant 0.43 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.29 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.29 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.25 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.25 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.22 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.22 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.22 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.2 isoniazid
hadA 732319 c.390G>A synonymous_variant 0.33 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.31 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.34 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.39 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.44 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.38 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.43 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.39 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.39 isoniazid
nusG 734078 c.-176C>A upstream_gene_variant 0.18 rifampicin
nusG 734093 c.-161A>C upstream_gene_variant 0.27 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.29 rifampicin
nusG 734111 c.-143A>G upstream_gene_variant 0.27 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.26 rifampicin
nusG 734120 c.-134T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
nusG 734123 c.-131C>T upstream_gene_variant 0.25 rifampicin
nusG 734129 c.-125G>C upstream_gene_variant 0.28 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.28 rifampicin
nusG 734135 c.-119G>T upstream_gene_variant 0.28 rifampicin
nusG 734144 c.-110G>T upstream_gene_variant 0.29 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.29 rifampicin
nusG 734165 c.-89G>A upstream_gene_variant 0.29 rifampicin
nusG 734173 c.-81C>G upstream_gene_variant 0.27 rifampicin
nusG 734175 c.-79_-77delGGTinsCTG upstream_gene_variant 0.27 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.26 rifampicin Uncertain significance
nusG 734183 c.-71C>T upstream_gene_variant 0.25 rifampicin
nusG 734186 c.-68G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
nusG 734205 c.-49A>C upstream_gene_variant 0.23 rifampicin
nusG 734403 c.150C>T synonymous_variant 0.42 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.43 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.51 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.53 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.59 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.64 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.66 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.68 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.58 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.48 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.45 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.47 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.45 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.42 rifampicin
nusG 734634 c.381G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734637 c.384G>C synonymous_variant 0.39 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.38 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.4 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.38 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.35 rifampicin
nusG 734664 c.411T>G synonymous_variant 0.35 rifampicin
nusG 734667 c.414C>T synonymous_variant 0.34 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.34 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734680 c.427_429delGCCinsAG frameshift_variant&missense_variant 0.34 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.43 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.42 rifampicin
nusG 734715 c.462G>C synonymous_variant 0.4 rifampicin
nusG 734718 c.465G>C synonymous_variant 0.37 rifampicin
nusG 734719 p.Ser156Ala missense_variant 0.37 rifampicin
nusG 734722 p.Thr157Ala missense_variant 0.38 rifampicin
nusG 734726 p.Arg158Lys missense_variant 0.42 rifampicin
nusG 734733 c.480T>C synonymous_variant 0.44 rifampicin
nusG 734742 c.489T>C synonymous_variant 0.46 rifampicin
nusG 734750 p.Ser166Thr missense_variant 0.49 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.49 rifampicin
nusG 734771 p.Ala173Val missense_variant 0.41 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.38 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.36 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.35 rifampicin
nusG 734791 p.Val180Thr missense_variant 0.37 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.37 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.41 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.43 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>A synonymous_variant 0.27 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.27 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.26 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.26 rifampicin
nusG 734870 p.Ser206Asn missense_variant 0.28 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.24 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.22 rifampicin
rpoB 760085 c.279C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760088 c.282C>G synonymous_variant 0.27 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.34 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.4 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.41 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.5 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.57 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.58 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.58 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760356 c.550_552delACCinsTG frameshift_variant&missense_variant 0.56 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.59 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.56 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.53 rifampicin
rpoB 760383 c.577C>T synonymous_variant 0.53 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.54 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.49 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.49 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.57 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.57 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.56 rifampicin
rpoB 760607 c.801G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.48 rifampicin
rpoB 760679 c.873A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.44 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.45 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.44 rifampicin
rpoB 760760 c.954C>G synonymous_variant 0.47 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.48 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.47 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.47 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.48 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.51 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.45 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.44 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.44 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.48 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.54 rifampicin
rpoB 760920 c.1114C>T synonymous_variant 0.55 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.55 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.56 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>T synonymous_variant 0.52 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 0.52 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.54 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.54 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.56 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.54 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.55 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.53 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.52 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761286 c.1480C>T synonymous_variant 0.44 rifampicin
rpoB 761289 p.Ser495Ala missense_variant 0.44 rifampicin
rpoB 761292 p.Val496Thr missense_variant 0.43 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.34 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.33 rifampicin
rpoB 761358 c.1552_1554delGTTinsAC frameshift_variant&missense_variant 0.32 rifampicin
rpoB 761373 p.Val523His missense_variant 0.29 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.41 rifampicin
rpoB 761411 c.1605G>T synonymous_variant 0.38 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.34 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.32 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.32 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.32 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.33 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.32 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.33 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.35 rifampicin
rpoB 761462 c.1656C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761465 c.1659G>C synonymous_variant 0.38 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.4 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.48 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.5 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.46 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.54 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.55 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.53 rifampicin
rpoB 761651 c.1845C>T synonymous_variant 0.53 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761660 c.1854G>C synonymous_variant 0.56 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.61 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.51 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.51 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.48 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.48 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.49 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.47 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.44 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.46 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.46 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.39 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.4 rifampicin
rpoB 761831 c.2025C>A synonymous_variant 0.38 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.42 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.39 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.4 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.44 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.43 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.44 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.46 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.49 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.5 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.46 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.43 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.43 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.43 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.57 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.55 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.55 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.56 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.51 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.5 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762221 c.2415G>A synonymous_variant 0.61 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.56 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.57 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.52 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.52 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.5 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.49 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.46 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.42 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.4 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.49 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.51 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.49 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.43 rifampicin
rpoC 762497 c.-873C>T upstream_gene_variant 0.42 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.41 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.41 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.33 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.33 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.33 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.36 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.38 rifampicin
rpoC 762575 c.-795C>T upstream_gene_variant 0.22 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.42 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.41 rifampicin
rpoC 762770 c.-600C>G upstream_gene_variant 0.46 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.42 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.41 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.45 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.44 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.45 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762824 c.-546C>T upstream_gene_variant 0.49 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762894 c.3088C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.5 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.51 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>G upstream_gene_variant 0.55 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.54 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.44 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.52 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.49 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.51 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763181 c.-189G>C upstream_gene_variant 0.46 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.42 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.41 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.41 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.4 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.29 rifampicin
rpoC 763262 c.-108C>A upstream_gene_variant 0.27 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.3 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.48 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.54 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.52 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.5 rifampicin
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.48 rifampicin
rpoC 763672 c.303C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>T synonymous_variant 0.47 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.48 rifampicin
rpoC 763714 c.345G>T synonymous_variant 0.48 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.47 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.5 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.47 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.47 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.47 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.48 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.49 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763835 p.Ala156Leu missense_variant 0.49 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.53 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.53 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.57 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.55 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.53 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.49 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.48 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.48 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763951 c.582G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.42 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.41 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.41 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.47 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.45 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.49 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.48 rifampicin
rpoC 764074 c.705C>T synonymous_variant 0.44 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.44 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.43 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.43 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.48 rifampicin
rpoC 764198 c.829C>T synonymous_variant 0.58 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.56 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.57 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.61 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.62 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.58 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.61 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764329 c.960C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>G synonymous_variant 0.51 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.48 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.48 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.47 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.47 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.47 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.49 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>T synonymous_variant 0.6 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.57 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.57 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764747 c.1378C>T synonymous_variant 0.56 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.63 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764915 c.1546C>T synonymous_variant 0.55 rifampicin
rpoC 764926 c.1557C>T synonymous_variant 0.54 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.5 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.5 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.43 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765028 c.1659C>T synonymous_variant 0.35 rifampicin
rpoC 765034 c.1665T>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1686delTCCinsAGT synonymous_variant 0.3 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.29 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.3 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765278 c.1909C>T synonymous_variant 0.26 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.31 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.37 rifampicin Uncertain significance
rpoC 765317 c.1948_1950delCTAinsTG frameshift_variant&stop_gained 0.44 rifampicin
rpoC 765326 p.His653Ala missense_variant 0.42 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.43 rifampicin Uncertain significance
rpoC 765339 p.Gln657Arg missense_variant 0.45 rifampicin Uncertain significance
rpoC 765346 c.1977C>T synonymous_variant 0.44 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765370 c.2001G>T synonymous_variant 0.49 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.49 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.51 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.59 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.59 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.59 rifampicin
rpoC 765415 c.2046G>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.59 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.59 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.62 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765490 c.2121C>T synonymous_variant 0.64 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.66 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.6 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.6 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.6 rifampicin
rpoC 765571 c.2202C>T synonymous_variant 0.59 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.58 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.58 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.57 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.6 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.6 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.55 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.55 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.59 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.56 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.56 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.55 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.57 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.54 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.57 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.47 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.51 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.53 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.49 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.43 rifampicin
rpoC 766061 p.Val898Leu missense_variant 0.43 rifampicin
rpoC 766078 c.2709G>A synonymous_variant 0.34 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.34 rifampicin
rpoC 766095 p.Thr909Ser missense_variant 0.31 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.31 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.33 rifampicin
rpoC 766141 c.2772C>T synonymous_variant 0.27 rifampicin
rpoC 766147 c.2778C>T synonymous_variant 0.2 rifampicin
rpoC 766148 p.Thr927Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 766270 c.2901G>C synonymous_variant 0.37 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.38 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.38 rifampicin
rpoC 766280 c.2911_2913delAGCinsGA frameshift_variant&missense_variant 0.4 rifampicin
rpoC 766288 c.2919C>T synonymous_variant 0.45 rifampicin
rpoC 766294 c.2925C>T synonymous_variant 0.51 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.56 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.58 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766354 c.2985C>G synonymous_variant 0.6 rifampicin
rpoC 766357 c.2988C>T synonymous_variant 0.61 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.62 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.62 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.62 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.6 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.6 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.56 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.49 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.42 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.39 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.39 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.41 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.49 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.48 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.49 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.52 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.49 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.46 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.38 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.37 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.38 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.44 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.49 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.52 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.5 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.5 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.53 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.58 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.54 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.51 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.51 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.51 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.51 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.53 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.54 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.56 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.57 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.57 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.59 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.54 rifampicin
rpoC 767149 c.3780C>A synonymous_variant 0.51 rifampicin
rpoC 767152 c.3783T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.54 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.48 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.29 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.3 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775847 c.2634G>T synonymous_variant 0.2 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775851 p.Ser877Thr missense_variant 0.19 clofazimine
bedaquiline
mmpL5 775864 p.Ala873Ser missense_variant 0.21 clofazimine
bedaquiline
mmpL5 775865 c.2616T>A synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775885 p.Ile866Leu missense_variant 0.29 clofazimine
bedaquiline
mmpL5 775886 c.2595A>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.25 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.24 clofazimine
bedaquiline
mmpL5 775973 c.2506_2508delTTGinsCC frameshift_variant&missense_variant 0.23 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775981 p.Leu834Met missense_variant 0.2 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.28 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.31 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.3 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.3 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.31 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.41 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.43 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.43 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.54 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.62 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.62 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.62 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.62 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.62 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.61 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.58 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.58 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.58 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.54 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.52 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.5 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.47 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.47 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.48 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.49 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.48 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.5 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.5 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.32 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.39 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.42 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.45 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.46 linezolid
rplC 800594 c.-215C>T upstream_gene_variant 0.48 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.48 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.51 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.49 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.46 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.48 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.48 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.47 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.48 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.43 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.41 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.4 linezolid
rplC 800798 c.-11_-8delTGGAinsC upstream_gene_variant 0.23 linezolid
rplC 800806 c.-3G>C upstream_gene_variant 0.24 linezolid
rplC 800807 c.-2C>T upstream_gene_variant 0.24 linezolid
rplC 800808 c.-1A>C upstream_gene_variant 0.24 linezolid Uncertain significance
rplC 800815 c.7C>A synonymous_variant 0.24 linezolid
rplC 800820 c.12G>A synonymous_variant 0.25 linezolid
rplC 800829 c.21C>G synonymous_variant 0.27 linezolid
rplC 800844 c.36T>C synonymous_variant 0.33 linezolid
rplC 800856 c.48A>G synonymous_variant 0.35 linezolid
rplC 800865 c.57A>G synonymous_variant 0.32 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.3 linezolid
rplC 800874 c.66A>G synonymous_variant 0.28 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.27 linezolid
rplC 800880 c.72A>G synonymous_variant 0.3 linezolid
rplC 800889 c.81C>G synonymous_variant 0.33 linezolid
rplC 800892 c.84G>C synonymous_variant 0.33 linezolid
rplC 800904 c.96G>C synonymous_variant 0.34 linezolid
rplC 800907 c.99C>G synonymous_variant 0.34 linezolid
rplC 800916 c.108A>G synonymous_variant 0.31 linezolid
rplC 800922 c.114C>G synonymous_variant 0.28 linezolid
rplC 800928 c.120C>T synonymous_variant 0.24 linezolid
rplC 800931 c.123G>C synonymous_variant 0.25 linezolid
rplC 800937 c.129A>G synonymous_variant 0.25 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.26 linezolid
rplC 800946 c.138T>C synonymous_variant 0.29 linezolid
rplC 800949 c.141T>C synonymous_variant 0.29 linezolid
rplC 800970 c.162T>C synonymous_variant 0.27 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.19 linezolid
rplC 801168 c.360C>A synonymous_variant 0.17 linezolid
rplC 801246 c.438C>T synonymous_variant 0.25 linezolid
rplC 801249 c.441T>C synonymous_variant 0.25 linezolid
rplC 801255 c.447C>T synonymous_variant 0.23 linezolid
rplC 801258 c.450C>G synonymous_variant 0.22 linezolid
rplC 801264 c.456C>T synonymous_variant 0.21 linezolid
rplC 801267 c.459A>C synonymous_variant 0.21 linezolid
rplC 801270 c.462T>C synonymous_variant 0.21 linezolid
rplC 801276 c.468G>C synonymous_variant 0.21 linezolid
rplC 801279 c.471G>C synonymous_variant 0.21 linezolid
rplC 801282 c.474G>C synonymous_variant 0.23 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 0.23 linezolid
rplC 801312 c.504G>T synonymous_variant 0.22 linezolid
rplC 801321 c.513C>T synonymous_variant 0.23 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.23 linezolid
rplC 801327 c.519C>T synonymous_variant 0.22 linezolid
rplC 801330 c.522G>C synonymous_variant 0.25 linezolid
rplC 801339 c.531T>C synonymous_variant 0.22 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.22 linezolid
rplC 801348 c.540T>G synonymous_variant 0.24 linezolid
rplC 801357 c.549T>C synonymous_variant 0.25 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.28 linezolid
rplC 801396 c.588T>C synonymous_variant 0.24 linezolid
rplC 801402 c.594T>C synonymous_variant 0.24 linezolid
rplC 801405 c.597T>C synonymous_variant 0.24 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303464 c.534A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303480 p.Gln184Glu missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303599 c.669C>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303647 c.717G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303653 c.723G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>T synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303746 c.816T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303869 c.939T>C synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303884 c.954T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303935 c.1005G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303965 c.1035G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304079 c.1149A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304088 c.1158C>T synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304133 c.1203G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304137 p.Ala403Ser missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304157 c.1227G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304162 p.Arg411Gln missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304173 p.Val415Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304205 c.1275C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304226 c.1296C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304232 c.1302G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304556 c.1626C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304672 p.Val581Ala missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.47 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304944 c.2014C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305039 c.2109G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305051 c.2121G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305144 c.2214G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
sigE 1364802 c.390C>A synonymous_variant 0.23 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.23 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.24 pyrazinamide
sigE 1364818 c.406_408delCTAinsTG frameshift_variant&stop_gained 0.25 pyrazinamide Uncertain significance
sigE 1364839 c.427T>C synonymous_variant 0.22 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.23 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.22 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.23 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.23 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.23 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.3 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.33 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.37 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.38 pyrazinamide
sigE 1364928 c.516C>T synonymous_variant 0.4 pyrazinamide
sigE 1364949 c.537C>T synonymous_variant 0.35 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.35 pyrazinamide
sigE 1364961 c.549A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
sigE 1364964 c.552T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.3 pyrazinamide
sigE 1364980 c.568_570delTTGinsCC frameshift_variant&missense_variant 0.3 pyrazinamide Uncertain significance
sigE 1364984 p.Ala191Asp missense_variant 0.3 pyrazinamide
sigE 1365000 c.588G>A synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
sigE 1365003 c.591T>C synonymous_variant 0.32 pyrazinamide
sigE 1365012 c.600G>C synonymous_variant 0.31 pyrazinamide
sigE 1365015 c.603G>C synonymous_variant 0.29 pyrazinamide
atpE 1460816 c.-229T>C upstream_gene_variant 0.29 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.3 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.31 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.3 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.29 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.27 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.27 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.32 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.25 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.2 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.25 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.3 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.34 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.36 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.38 bedaquiline
atpE 1461131 c.87T>C synonymous_variant 0.39 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.38 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.39 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.39 bedaquiline
atpE 1461158 c.114T>C synonymous_variant 0.42 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.42 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.42 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.39 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.4 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.39 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.39 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.37 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.24 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473417 n.-241C>T upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474288 n.632_634delCTT non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474969 n.1312G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.66 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476717 n.3060C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673568 c.-634C>G upstream_gene_variant 0.27 ethionamide
isoniazid
fabG1 1673569 p.Val44Ile missense_variant 0.29 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.37 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.36 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>C upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.31 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.31 ethionamide
isoniazid
inhA 1673601 c.-601G>A upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673610 c.-592C>T upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.34 ethionamide
isoniazid
inhA 1673625 c.-577C>G upstream_gene_variant 0.36 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.4 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.29 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.28 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673901 c.-301A>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.24 ethionamide
isoniazid
inhA 1673916 c.-286A>T upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673919 c.-283G>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1673934 c.-268C>T upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.22 ethionamide
isoniazid
inhA 1673946 c.-256C>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673962 p.Asn175Gly missense_variant 0.24 ethionamide
isoniazid
inhA 1673976 c.-226T>C upstream_gene_variant 0.25 ethionamide
isoniazid
inhA 1673988 c.-214G>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.3 ethionamide
isoniazid
inhA 1674012 c.-190C>G upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.3 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.28 ethionamide
isoniazid
fabG1 1674049 p.Gln204Glu missense_variant 0.28 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1674060 c.-142A>C upstream_gene_variant 0.35 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.34 ethionamide
isoniazid
inhA 1674084 c.-118C>G upstream_gene_variant 0.34 ethionamide
isoniazid
inhA 1674117 c.-85C>G upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674123 c.-79T>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1674129 c.-73C>T upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674132 c.-70T>C upstream_gene_variant 0.28 ethionamide
isoniazid
fabG1 1674136 p.Ser233Ala missense_variant 0.25 ethionamide
isoniazid
inhA 1674141 c.-61T>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1674199 c.-3C>G upstream_gene_variant 0.25 ethionamide
isoniazid Uncertain significance
inhA 1674205 p.Thr2Ala missense_variant 0.29 ethionamide
isoniazid Uncertain significance
inhA 1674216 c.15G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674235 c.34_36delGTTinsAC frameshift_variant&missense_variant 0.33 ethionamide
isoniazid
inhA 1674239 p.Ser13Thr missense_variant 0.33 ethionamide
isoniazid
inhA 1674243 c.42A>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674255 c.54C>T synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674264 c.63C>T synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674267 c.66G>T synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674279 c.78A>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674280 p.Arg27Lys missense_variant 0.31 ethionamide
isoniazid
inhA 1674284 p.Val28Ala missense_variant 0.31 ethionamide
isoniazid
inhA 1674295 p.Gln32Ala missense_variant 0.33 ethionamide
isoniazid
inhA 1674300 c.99C>T synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674303 c.102C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674307 c.106C>T synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674331 c.130C>T synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674336 c.135G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674352 p.Thr51Ala missense_variant 0.28 ethionamide Uncertain significance
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.31 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.33 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674573 c.372G>A synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.44 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.44 ethionamide
isoniazid
inhA 1674604 c.403C>T synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674687 c.486G>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.57 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674746 p.Tyr182Ser missense_variant 0.51 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.52 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674780 c.579T>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.45 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.34 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.31 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674858 c.657G>A synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.28 ethionamide
isoniazid
inhA 1674934 c.733C>T synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674966 c.765T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.31 ethionamide
isoniazid
inhA 1674993 c.792G>A synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674994 p.His265Ser missense_variant 0.27 ethionamide
isoniazid
rpsA 1833515 c.-27_-24delCAACinsAAA upstream_gene_variant 0.3 pyrazinamide
rpsA 1833541 c.-1T>C upstream_gene_variant 0.42 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.43 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.44 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.43 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.53 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.61 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
rpsA 1833772 c.231C>T synonymous_variant 0.61 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.51 pyrazinamide
rpsA 1833796 c.255G>A synonymous_variant 0.52 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833844 c.303C>T synonymous_variant 0.53 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.52 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.53 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.57 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.59 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.39 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.37 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.45 pyrazinamide
rpsA 1834259 c.718_720delCTAinsTG frameshift_variant&stop_gained 0.48 pyrazinamide Uncertain significance
rpsA 1834264 c.723G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.56 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834433 c.892_894delCCGinsGT frameshift_variant&missense_variant 0.45 pyrazinamide Uncertain significance
rpsA 1834451 c.910T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.53 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 0.57 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.51 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.51 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.48 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.48 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.47 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.46 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.44 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834828 c.1287C>G synonymous_variant 0.33 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.54 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.53 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.49 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.49 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.53 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.51 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.48 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.48 linezolid
tsnR 1853459 c.-147G>T upstream_gene_variant 0.48 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.48 linezolid
tsnR 1853468 c.-138C>G upstream_gene_variant 0.44 linezolid
tsnR 1853469 c.-137G>T upstream_gene_variant 0.44 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.44 linezolid
tsnR 1853484 c.-122_-121delAGinsGC upstream_gene_variant 0.38 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.34 linezolid
tsnR 1853498 c.-108G>C upstream_gene_variant 0.33 linezolid
tsnR 1853504 c.-102C>G upstream_gene_variant 0.33 linezolid
tsnR 1853517 c.-89G>A upstream_gene_variant 0.31 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.26 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917951 c.12T>C synonymous_variant 0.22 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.24 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.27 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.26 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>C synonymous_variant 0.25 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.24 capreomycin
bacA 2063565 c.1164C>T synonymous_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064996 c.-268G>C upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
ndh 2102260 c.783C>T synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102317 c.726A>G synonymous_variant 0.47 ethionamide
delamanid
isoniazid
ndh 2102320 c.723G>C synonymous_variant 0.46 ethionamide
delamanid
isoniazid
ndh 2102328 p.Leu239Met missense_variant 0.46 ethionamide
delamanid
isoniazid
ndh 2102334 p.Gln237Glu missense_variant 0.46 ethionamide
delamanid
isoniazid
ndh 2102337 c.706T>C synonymous_variant 0.46 ethionamide Not assoc w R - Interim
delamanid
isoniazid
ndh 2102344 c.699T>G synonymous_variant 0.45 ethionamide
delamanid
isoniazid
ndh 2102347 c.696G>C synonymous_variant 0.45 ethionamide
delamanid
isoniazid
ndh 2102350 c.693G>C synonymous_variant 0.43 ethionamide
delamanid
isoniazid
ndh 2102359 c.684C>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102365 p.Ala226Glu missense_variant 0.33 ethionamide
delamanid
isoniazid Uncertain significance
ndh 2102371 c.670_672delATGinsTC frameshift_variant&missense_variant 0.33 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102377 c.666A>G synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102386 c.657G>C synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102389 c.654G>C synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102392 c.651C>G synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102398 c.645C>T synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102401 c.642T>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102407 c.636T>C synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102422 c.621C>G synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102443 c.598_600delGCAinsTG frameshift_variant&missense_variant 0.27 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102450 p.Lys198Arg missense_variant 0.24 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155716 c.396T>C synonymous_variant 0.33 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.32 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.29 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.28 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.28 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.27 isoniazid
katG 2155749 c.363C>T synonymous_variant 0.27 isoniazid Not assoc w R - Interim
katG 2155752 c.360C>T synonymous_variant 0.26 isoniazid
katG 2155782 c.330C>G synonymous_variant 0.24 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.24 isoniazid
katG 2155794 p.Ala106Ser missense_variant 0.23 isoniazid
katG 2155824 c.288C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2221939 p.Arg409Gln missense_variant 0.98 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.53 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.47 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.39 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.3 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.34 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.37 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.43 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.43 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.43 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.44 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.43 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.44 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.43 isoniazid
kasA 2518261 p.Glu49Asp missense_variant 0.42 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.24 isoniazid
kasA 2518283 c.169_171delGCGinsCC frameshift_variant&missense_variant 0.19 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.2 isoniazid
kasA 2518483 c.369C>T synonymous_variant 0.25 isoniazid
kasA 2518488 p.Ser125Thr missense_variant 0.31 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.38 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.38 isoniazid
kasA 2518510 c.396C>T synonymous_variant 0.38 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.41 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.44 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.47 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.47 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.44 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.47 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.51 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.49 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.53 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.53 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.57 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.59 isoniazid
kasA 2518633 c.519G>A synonymous_variant 0.59 isoniazid
kasA 2518636 c.522C>G synonymous_variant 0.6 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.59 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.6 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.6 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.6 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.61 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.69 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.67 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.67 isoniazid
kasA 2518717 c.603C>A synonymous_variant 0.67 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.67 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.65 isoniazid
kasA 2518768 c.654C>A synonymous_variant 0.64 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.62 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.59 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.58 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.58 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.57 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.53 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.51 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.49 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.44 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.33 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.33 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.3 isoniazid
kasA 2518882 c.768C>T synonymous_variant 0.3 isoniazid
kasA 2518897 c.783G>A synonymous_variant 0.25 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.25 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.23 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.23 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.19 isoniazid
ahpC 2726660 c.468C>T synonymous_variant 0.2 isoniazid
folC 2746308 p.Arg431Ser missense_variant 0.24 para-aminosalicylic_acid
folC 2746321 c.1278A>G synonymous_variant 0.25 para-aminosalicylic_acid
folC 2746324 c.1275C>T synonymous_variant 0.26 para-aminosalicylic_acid
folC 2746335 p.Gly422Arg missense_variant 0.29 para-aminosalicylic_acid
folC 2746336 c.1263C>G synonymous_variant 0.29 para-aminosalicylic_acid
folC 2746351 c.1246_1248delGCCinsTG frameshift_variant&missense_variant 0.3 para-aminosalicylic_acid
folC 2746360 c.1239T>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2746363 c.1236G>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2746375 c.1224G>C synonymous_variant 0.28 para-aminosalicylic_acid
folC 2746378 c.1221G>A synonymous_variant 0.28 para-aminosalicylic_acid
folC 2746393 c.1206C>G synonymous_variant 0.3 para-aminosalicylic_acid
folC 2746399 c.1198_1200delTCCinsGT frameshift_variant&missense_variant 0.26 para-aminosalicylic_acid
folC 2746402 c.1197T>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2746416 p.Glu395Gln missense_variant 0.26 para-aminosalicylic_acid
folC 2746420 c.1179A>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2746551 p.Ile350Leu missense_variant 0.22 para-aminosalicylic_acid
folC 2746558 c.1041G>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2746564 c.1035A>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2746576 c.1023C>G synonymous_variant 0.44 para-aminosalicylic_acid
folC 2746584 c.1015T>C synonymous_variant 0.43 para-aminosalicylic_acid
folC 2746594 c.1005T>C synonymous_variant 0.44 para-aminosalicylic_acid
folC 2746599 p.Thr334Ala missense_variant 0.45 para-aminosalicylic_acid
folC 2746600 c.999C>T synonymous_variant 0.45 para-aminosalicylic_acid
folC 2746609 c.990T>C synonymous_variant 0.49 para-aminosalicylic_acid
folC 2746618 c.981G>C synonymous_variant 0.54 para-aminosalicylic_acid
folC 2746621 c.978C>G synonymous_variant 0.52 para-aminosalicylic_acid
folC 2746624 c.975C>G synonymous_variant 0.55 para-aminosalicylic_acid
folC 2746631 p.Gly323Val missense_variant 0.52 para-aminosalicylic_acid
folC 2746642 c.957T>A synonymous_variant 0.54 para-aminosalicylic_acid
folC 2746663 c.936T>C synonymous_variant 0.57 para-aminosalicylic_acid
folC 2746666 c.933C>G synonymous_variant 0.57 para-aminosalicylic_acid
folC 2746677 p.Ser308Ala missense_variant 0.56 para-aminosalicylic_acid
folC 2746678 c.921T>G synonymous_variant 0.56 para-aminosalicylic_acid
folC 2746687 c.912C>G synonymous_variant 0.61 para-aminosalicylic_acid
folC 2746693 c.906G>C synonymous_variant 0.62 para-aminosalicylic_acid
folC 2746714 c.885T>C synonymous_variant 0.52 para-aminosalicylic_acid
folC 2746728 c.871T>C synonymous_variant 0.45 para-aminosalicylic_acid
folC 2746734 p.Ile289Val missense_variant 0.47 para-aminosalicylic_acid
folC 2746741 c.858C>T synonymous_variant 0.38 para-aminosalicylic_acid
folC 2746744 c.855T>G synonymous_variant 0.38 para-aminosalicylic_acid
folC 2746750 c.849C>T synonymous_variant 0.34 para-aminosalicylic_acid
folC 2746753 c.846C>G synonymous_variant 0.34 para-aminosalicylic_acid
folC 2746765 c.834A>G synonymous_variant 0.24 para-aminosalicylic_acid
folC 2746770 c.829C>T synonymous_variant 0.24 para-aminosalicylic_acid
folC 2746771 c.828A>G synonymous_variant 0.26 para-aminosalicylic_acid
folC 2746777 c.822T>G synonymous_variant 0.25 para-aminosalicylic_acid
folC 2746785 p.Val272Ile missense_variant 0.21 para-aminosalicylic_acid
folC 2746791 p.Ile270Val missense_variant 0.21 para-aminosalicylic_acid
folC 2747023 c.576C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747032 c.567A>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747065 c.534C>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747128 c.471G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747134 c.465C>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747264 p.Gly112Ser missense_variant 0.27 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747287 c.310_312delCCGinsGC frameshift_variant&missense_variant 0.28 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.4 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.42 para-aminosalicylic_acid
folC 2747326 c.273G>A synonymous_variant 0.44 para-aminosalicylic_acid
folC 2747334 c.265C>T synonymous_variant 0.46 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.48 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.5 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.48 para-aminosalicylic_acid
folC 2747362 c.237G>A synonymous_variant 0.49 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.45 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.44 para-aminosalicylic_acid
folC 2747410 c.187_188delAG frameshift_variant 0.42 para-aminosalicylic_acid
folC 2747414 c.184_185insTG frameshift_variant 0.41 para-aminosalicylic_acid
folC 2747419 c.180C>G synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747467 p.Asp44Glu missense_variant 0.35 para-aminosalicylic_acid
folC 2747473 p.Arg42Lys missense_variant 0.32 para-aminosalicylic_acid
folC 2747491 c.108A>G synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747497 c.102C>G synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747500 c.99A>G synonymous_variant 0.23 para-aminosalicylic_acid
Rv2477c 2782393 c.1650C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782396 c.1647G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782405 c.1638A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782408 c.1635T>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782414 p.Asp543Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782418 p.Val542Ala missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2782426 c.1617G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782432 c.1609_1611delGTGinsAC frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782450 c.1593C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782531 c.1512C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782636 c.1407G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782654 c.1389G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782660 c.1383C>A synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782669 c.1374A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782708 c.1335C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782714 c.1329A>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782720 c.1323T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782738 c.1305C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782744 c.1299A>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782753 c.1290G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782759 c.1284A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782885 c.1158G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782924 c.1119G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.57 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783087 p.Asn319Ser missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.46 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.49 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783297 p.Ala249Gly missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.2 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783433 p.Ser204Cys missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783434 c.609C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783437 c.606G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783458 c.585G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783536 c.507G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783554 c.489C>T synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.46 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859765 c.654G>C synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859798 c.621G>C synonymous_variant 0.37 clofazimine
bedaquiline
pepQ 2859807 c.612C>T synonymous_variant 0.38 clofazimine
bedaquiline
pepQ 2859834 c.585T>G synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859843 c.576G>C synonymous_variant 0.29 clofazimine
bedaquiline
pepQ 2859852 c.567A>G synonymous_variant 0.26 clofazimine
bedaquiline
pepQ 2859864 c.555T>C synonymous_variant 0.28 clofazimine
bedaquiline
pepQ 2859870 c.549T>C synonymous_variant 0.32 clofazimine
bedaquiline
pepQ 2859903 c.516G>C synonymous_variant 0.32 clofazimine
bedaquiline
pepQ 2859908 p.Gln171Glu missense_variant 0.33 clofazimine
bedaquiline
pepQ 2859909 c.510G>C synonymous_variant 0.33 clofazimine
bedaquiline
pepQ 2859918 c.501A>G synonymous_variant 0.34 clofazimine
bedaquiline
pepQ 2859924 c.495G>C synonymous_variant 0.32 clofazimine
bedaquiline
pepQ 2859938 p.Gly161Ser missense_variant 0.24 clofazimine
bedaquiline
pepQ 2859939 c.480C>G synonymous_variant 0.24 clofazimine
bedaquiline
pepQ 2859942 c.477C>G synonymous_variant 0.24 clofazimine
bedaquiline
pepQ 2859950 c.469T>C synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2859963 c.456C>G synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2859966 c.453T>C synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2859972 c.447A>G synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2859975 c.444A>G synonymous_variant 0.21 clofazimine
bedaquiline
pepQ 2859981 c.438C>G synonymous_variant 0.21 clofazimine
bedaquiline
pepQ 2859984 c.435A>G synonymous_variant 0.21 clofazimine
bedaquiline
pepQ 2859987 c.432A>G synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2860017 c.402T>C synonymous_variant 0.17 clofazimine
bedaquiline Not assoc w R - Interim
Rv2681 2996560 c.-179G>C upstream_gene_variant 0.25 capreomycin
Rv2681 2996563 c.-176A>C upstream_gene_variant 0.24 capreomycin
Rv2681 2996569 c.-170C>A upstream_gene_variant 0.27 capreomycin
Rv2681 2996593 c.-146T>C upstream_gene_variant 0.29 capreomycin
Rv2681 2996602 c.-137G>C upstream_gene_variant 0.28 capreomycin
Rv2681 2996608 c.-131A>G upstream_gene_variant 0.28 capreomycin
Rv2681 2996611 c.-128G>C upstream_gene_variant 0.26 capreomycin
Rv2681 2996617 c.-122A>G upstream_gene_variant 0.28 capreomycin
Rv2681 2996623 c.-116G>C upstream_gene_variant 0.3 capreomycin
Rv2680 2996628 c.524_525insGT frameshift_variant 0.29 capreomycin Uncertain significance
Rv2680 2996634 p.Pro177Arg missense_variant 0.26 capreomycin
Rv2680 2996637 p.Asp178Gly missense_variant 0.26 capreomycin
Rv2680 2996639 c.536_537delTG frameshift_variant 0.27 capreomycin Uncertain significance
Rv2680 2996646 p.Ala181Gly missense_variant 0.25 capreomycin
Rv2680 2996654 p.Gln184Glu missense_variant 0.26 capreomycin Uncertain significance
Rv2680 2996668 p.Asp188Glu missense_variant 0.26 capreomycin
Rv2681 2996671 c.-68C>A upstream_gene_variant 0.23 capreomycin
Rv2752c 3065028 c.1162_1164delGTGinsAT frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065064 c.1128G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 0.33 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 0.37 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065115 c.1077C>G synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065126 p.Ser356Ala missense_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065127 c.1065G>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065130 p.Ala354Glu missense_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065133 c.1059T>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065142 c.1050A>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065154 c.1038G>A synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065163 c.1029C>T synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065166 c.1026C>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065183 p.Ser337Ala missense_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065520 c.672G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065532 c.660A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065947 p.Gly82Ala missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065957 c.235T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065982 c.210G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065988 c.204A>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066003 c.189C>T synonymous_variant 0.31 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
Rv2752c 3066011 c.181C>T synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066012 c.180C>T synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066021 c.171C>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066045 c.147T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066606 c.-415C>A upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066609 c.-418C>T upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066665 c.-474G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066672 c.-483_-481delGTGinsAA upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066676 c.-485C>T upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066686 c.-495G>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066696 c.-505T>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066713 c.-522C>T upstream_gene_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.47 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066741 c.-550T>C upstream_gene_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066752 c.-561C>T upstream_gene_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-567_-565delCGGinsAC upstream_gene_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.44 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066783 c.-592G>C upstream_gene_variant 0.45 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066846 c.-655G>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067223 c.723G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067229 c.717C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067245 p.Thr234Ile missense_variant 0.29 para-aminosalicylic_acid
thyX 3067249 p.Thr233Ser missense_variant 0.3 para-aminosalicylic_acid
thyX 3067250 c.694_696delGTGinsAC frameshift_variant&missense_variant 0.31 para-aminosalicylic_acid
thyX 3067273 p.Ala225Thr missense_variant 0.36 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.36 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067313 c.633G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067424 c.522G>A synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067673 c.273C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067676 c.270C>A synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.35 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.36 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067796 c.150C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.32 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067924 p.Arg8Gly missense_variant 0.22 para-aminosalicylic_acid
thyX 3067935 p.Thr4Ile missense_variant 0.19 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073845 c.627C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.21 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.3 para-aminosalicylic_acid
thyA 3073890 c.580_582delTTGinsCC frameshift_variant&missense_variant 0.32 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.36 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3073971 c.501C>T synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073983 c.489C>T synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074045 c.427C>T synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.33 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074121 c.351T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074124 c.348G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074134 p.Ser113Thr missense_variant 0.23 para-aminosalicylic_acid
thyA 3074142 c.330C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.22 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612622 c.495C>T synonymous_variant 0.2 pyrazinamide
Rv3236c 3612628 c.489G>C synonymous_variant 0.22 pyrazinamide
Rv3236c 3612667 c.450T>G synonymous_variant 0.25 pyrazinamide
Rv3236c 3612676 c.441A>G synonymous_variant 0.24 pyrazinamide
Rv3236c 3612694 p.Arg141Gln missense_variant 0.24 pyrazinamide
Rv3236c 3612708 c.409T>C synonymous_variant 0.27 pyrazinamide
Rv3236c 3612721 c.396G>C synonymous_variant 0.31 pyrazinamide
Rv3236c 3612724 c.393T>C synonymous_variant 0.34 pyrazinamide
Rv3236c 3612733 c.384C>A synonymous_variant 0.37 pyrazinamide
Rv3236c 3612736 c.381T>C synonymous_variant 0.36 pyrazinamide
Rv3236c 3612748 c.369G>C synonymous_variant 0.37 pyrazinamide
Rv3236c 3612757 c.358_360delGGTinsTC frameshift_variant&missense_variant 0.3 pyrazinamide Uncertain significance
Rv3236c 3612760 c.357C>G synonymous_variant 0.3 pyrazinamide
Rv3236c 3612769 c.348T>G synonymous_variant 0.3 pyrazinamide
Rv3236c 3612772 c.345T>C synonymous_variant 0.31 pyrazinamide
Rv3236c 3612780 c.337T>C synonymous_variant 0.29 pyrazinamide
Rv3236c 3612781 c.336G>T synonymous_variant 0.28 pyrazinamide
Rv3236c 3612786 c.331T>C synonymous_variant 0.27 pyrazinamide
Rv3236c 3612787 c.330T>A synonymous_variant 0.26 pyrazinamide
Rv3236c 3612796 c.321G>C synonymous_variant 0.28 pyrazinamide
Rv3236c 3612799 c.316_318delGTGinsAC frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
Rv3236c 3612805 c.312T>C synonymous_variant 0.28 pyrazinamide
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612829 c.288T>C synonymous_variant 0.24 pyrazinamide
Rv3236c 3612835 p.Gly94Ala missense_variant 0.24 pyrazinamide
lpqB 3623444 c.1467T>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623449 c.1462C>T synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3623459 c.1452G>C synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3623465 c.1446G>C synonymous_variant 0.4 bedaquiline
rifampicin
lpqB 3623468 c.1443T>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623472 p.Tyr480Phe missense_variant 0.37 bedaquiline
rifampicin
lpqB 3623484 p.Phe476Tyr missense_variant 0.4 bedaquiline
rifampicin
lpqB 3623489 c.1422C>G synonymous_variant 0.41 bedaquiline
rifampicin
lpqB 3623492 c.1419T>C synonymous_variant 0.43 bedaquiline
rifampicin
lpqB 3623512 p.Gly467Ser missense_variant 0.49 bedaquiline
rifampicin
lpqB 3623516 c.1395C>G synonymous_variant 0.49 bedaquiline
rifampicin
lpqB 3623519 c.1392C>T synonymous_variant 0.49 bedaquiline
rifampicin
lpqB 3623522 c.1389G>A synonymous_variant 0.49 bedaquiline
rifampicin
lpqB 3623528 c.1383G>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623531 c.1380T>C synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3623552 c.1359G>C synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.35 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3623570 c.1341A>G synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3623573 c.1338T>G synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3623576 c.1335T>C synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3623580 p.Asn444Thr missense_variant 0.35 bedaquiline
rifampicin
lpqB 3623587 p.Ala442Pro missense_variant 0.35 bedaquiline
rifampicin
lpqB 3623597 c.1314C>G synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3623601 p.Ser437Thr missense_variant 0.24 bedaquiline
rifampicin
lpqB 3623612 p.Thr433Val missense_variant 0.24 bedaquiline
rifampicin
lpqB 3624077 c.834G>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624133 c.778A>C synonymous_variant 0.41 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.51 bedaquiline
rifampicin
lpqB 3624173 c.738A>C synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624179 c.732C>G synonymous_variant 0.54 bedaquiline
rifampicin
lpqB 3624188 c.723G>A synonymous_variant 0.53 bedaquiline
rifampicin
lpqB 3624194 c.717C>G synonymous_variant 0.52 bedaquiline
rifampicin
lpqB 3624200 c.711A>C synonymous_variant 0.51 bedaquiline
rifampicin
lpqB 3624209 c.702A>C synonymous_variant 0.52 bedaquiline
rifampicin
lpqB 3624224 c.687T>C synonymous_variant 0.52 bedaquiline
rifampicin
lpqB 3624242 c.669A>G synonymous_variant 0.48 bedaquiline
rifampicin
lpqB 3624245 c.666A>G synonymous_variant 0.48 bedaquiline
rifampicin
lpqB 3624254 c.657T>C synonymous_variant 0.48 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624266 c.645T>C synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624269 c.642G>C synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624276 p.Arg212His missense_variant 0.51 bedaquiline
rifampicin
lpqB 3624287 c.624G>C synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624290 c.621C>G synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624296 c.615T>G synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624299 c.612G>C synonymous_variant 0.4 bedaquiline
rifampicin
lpqB 3624302 c.607_609delCTGinsAC frameshift_variant&missense_variant 0.38 bedaquiline
rifampicin Uncertain significance
lpqB 3624308 c.603A>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624316 p.Val199Ile missense_variant 0.39 bedaquiline
rifampicin
lpqB 3624317 c.594C>G synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624323 c.588G>C synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624331 c.580C>T synonymous_variant 0.41 bedaquiline
rifampicin
lpqB 3624339 p.Arg191His missense_variant 0.42 bedaquiline
rifampicin
lpqB 3624346 p.Ser189Pro missense_variant 0.43 bedaquiline
rifampicin
lpqB 3624359 c.552C>T synonymous_variant 0.46 bedaquiline
rifampicin
lpqB 3624365 c.546T>C synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.47 bedaquiline
rifampicin
lpqB 3624392 c.519C>T synonymous_variant 0.46 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624407 c.504C>G synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624416 c.495G>A synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624650 c.261G>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624656 c.255C>T synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624662 c.249C>T synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.24 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.32 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624745 p.Leu56Phe missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.27 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625141 c.-231T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625156 c.-246G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.29 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625183 c.-273G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625189 c.-279A>T upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625204 c.1408_1410delTCGinsGC frameshift_variant&missense_variant 0.28 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625207 c.-297C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>G upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625246 c.-336G>A upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625314 c.-404C>A upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625510 c.-600T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.38 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.39 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625606 c.-696C>T upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.4 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625660 c.954C>T synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625683 c.-773C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.54 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.57 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625888 c.-978G>T upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625909 c.-999T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.36 bedaquiline
rifampicin
mtrB 3625930 c.684C>G synonymous_variant 0.35 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.672C>G synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3625945 c.669A>G synonymous_variant 0.31 bedaquiline
rifampicin
mtrB 3625951 c.663A>G synonymous_variant 0.29 bedaquiline
rifampicin
mtrB 3625955 p.Leu220Ala missense_variant 0.31 bedaquiline
rifampicin
mtrB 3625967 p.Ala216Ile missense_variant 0.29 bedaquiline
rifampicin
mtrB 3625972 c.642G>C synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3625978 c.636T>C synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3625988 p.Thr209Gln missense_variant 0.25 bedaquiline
rifampicin
mtrB 3625993 c.621G>C synonymous_variant 0.26 bedaquiline
rifampicin
mtrB 3625999 c.615A>G synonymous_variant 0.27 bedaquiline
rifampicin
mtrB 3626006 p.Ser203Asn missense_variant 0.28 bedaquiline
rifampicin
mtrB 3626009 p.Ala202Lys missense_variant 0.27 bedaquiline
rifampicin
mtrB 3626017 c.597T>C synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626029 c.585A>G synonymous_variant 0.23 bedaquiline
rifampicin
mtrB 3626092 c.522T>G synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3626095 p.Glu173Asp missense_variant 0.21 bedaquiline
rifampicin
mtrB 3626101 p.Gln171His missense_variant 0.22 bedaquiline
rifampicin
mtrB 3626107 c.505_507delACGinsTC frameshift_variant&missense_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626124 p.Ala164Ser missense_variant 0.25 bedaquiline
rifampicin
mtrB 3626125 c.489C>G synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626134 c.480C>G synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626157 p.Ala153Ser missense_variant 0.25 bedaquiline
rifampicin
mtrB 3626158 p.Asn152Ser missense_variant 0.23 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626179 c.435A>G synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3626684 c.-71G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626708 c.642G>A synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626711 c.-98T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626720 c.-107G>A upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626735 c.-122C>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626744 c.-131G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626773 c.-160C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.41 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3626894 c.-281C>T upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.65 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrB 3626990 c.-377G>T upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.43 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627269 c.81G>T synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627277 c.73C>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3642560 c.1026T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642566 c.1032A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642578 c.1044C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiB 3642581 c.1047A>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiB 3642587 p.Met351Ile missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiB 3642609 c.1075_1076delAGinsTC synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiB 3642743 c.1209T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642749 c.1215T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642758 c.1224C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642763 p.Asp410Ala missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642770 c.1236G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642773 p.Asp413Glu missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642781 p.Val416Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
alr 3840274 p.Val383Leu missense_variant 0.32 cycloserine
alr 3840275 c.1146T>G synonymous_variant 0.32 cycloserine
alr 3840293 c.1128T>G synonymous_variant 0.31 cycloserine
alr 3840296 c.1125G>C synonymous_variant 0.31 cycloserine
alr 3840308 c.1111_1113delCGGinsAT frameshift_variant&missense_variant 0.29 cycloserine
alr 3840312 p.Ile370Thr missense_variant 0.29 cycloserine
alr 3840328 c.1093T>C synonymous_variant 0.3 cycloserine
alr 3840329 c.1092T>C synonymous_variant 0.3 cycloserine
alr 3840344 c.1077A>G synonymous_variant 0.28 cycloserine
alr 3840353 c.1068T>C synonymous_variant 0.25 cycloserine
alr 3840356 c.1064_1065delTTinsACC frameshift_variant&missense_variant 0.24 cycloserine
alr 3840368 c.1050_1053delGGGCinsCGG frameshift_variant&missense_variant 0.28 cycloserine
alr 3840380 c.1039_1041delATGinsGC frameshift_variant&missense_variant 0.29 cycloserine
alr 3840947 c.474G>C synonymous_variant 0.23 cycloserine
alr 3840968 c.453G>C synonymous_variant 0.26 cycloserine
alr 3840980 c.441G>C synonymous_variant 0.26 cycloserine
alr 3840986 p.Val145Ala missense_variant 0.26 cycloserine
alr 3840994 p.His143Asp missense_variant 0.25 cycloserine
alr 3841001 c.420A>G synonymous_variant 0.26 cycloserine
alr 3841006 p.Asp139Asn missense_variant 0.27 cycloserine
alr 3841010 c.411A>G synonymous_variant 0.27 cycloserine
alr 3841013 c.408C>T synonymous_variant 0.27 cycloserine
alr 3841017 p.Leu135Glu missense_variant 0.27 cycloserine
alr 3841022 c.399C>G synonymous_variant 0.27 cycloserine
alr 3841028 c.393G>C synonymous_variant 0.27 cycloserine
alr 3841033 p.Val130Ile missense_variant 0.28 cycloserine
alr 3841037 c.384G>C synonymous_variant 0.27 cycloserine
alr 3841079 c.342T>C synonymous_variant 0.23 cycloserine
rpoA 3877533 c.975C>T synonymous_variant 0.23 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.25 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.22 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.49 rifampicin
rpoA 3877632 c.876G>A synonymous_variant 0.48 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.49 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.51 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.51 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.55 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.53 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.53 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.52 rifampicin
rpoA 3877896 c.612G>T synonymous_variant 0.56 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.53 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.52 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.56 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.52 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.5 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.5 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.49 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.5 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.53 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.53 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.53 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.49 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.47 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.47 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.5 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.57 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.55 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.54 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.53 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.53 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.53 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.53 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>G synonymous_variant 0.62 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.62 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.58 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.53 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.48 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.5 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878325 c.183C>T synonymous_variant 0.45 rifampicin
rpoA 3878331 c.177A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.46 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.45 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.45 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.45 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.44 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.44 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.45 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.46 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.46 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.46 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.45 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.46 rifampicin
rpoA 3878459 p.Asn17Asp missense_variant 0.45 rifampicin
rpoA 3878465 p.Thr15Ser missense_variant 0.45 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.45 rifampicin
rpoA 3878475 c.33G>A synonymous_variant 0.43 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.42 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.41 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.4 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.37 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.37 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.39 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.43 rifampicin
rpoA 3878769 c.-262C>A upstream_gene_variant 0.44 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.48 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.54 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.54 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.57 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.53 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.52 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.58 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.49 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.42 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.37 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.33 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878956 c.-449G>C upstream_gene_variant 0.42 rifampicin
rpoA 3878962 c.-455G>A upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878968 c.-461T>G upstream_gene_variant 0.39 rifampicin
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.44 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3879001 c.-494C>T upstream_gene_variant 0.38 rifampicin
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.38 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.38 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.37 rifampicin
rpoA 3879034 c.-527G>A upstream_gene_variant 0.37 rifampicin
rpoA 3879040 c.-535_-533delGTGinsTCC upstream_gene_variant 0.36 rifampicin
rpoA 3879050 c.-543A>C upstream_gene_variant 0.38 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.43 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.45 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.49 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.48 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879117 c.-610C>T upstream_gene_variant 0.48 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.46 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.46 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.43 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.45 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.41 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.46 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.36 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.32 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.32 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.35 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.38 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986651 c.-193G>A upstream_gene_variant 0.32 delamanid
pretomanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.28 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.27 delamanid
pretomanid
clpC1 4038239 c.2466T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.26 pyrazinamide
clpC1 4038262 p.Asp815Asn missense_variant 0.25 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.25 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.25 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038281 c.2424C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038289 p.Asn806Asp missense_variant 0.29 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038325 p.Val794Ile missense_variant 0.31 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.37 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.43 pyrazinamide
clpC1 4038644 p.Glu687Asp missense_variant 0.44 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.37 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.36 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.37 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038692 c.2013C>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>G synonymous_variant 0.55 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.51 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.49 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.49 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.49 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.45 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039124 c.1581C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039139 p.Glu522Val missense_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.3 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.22 pyrazinamide
clpC1 4039258 p.Gln483Glu missense_variant 0.22 pyrazinamide
clpC1 4039259 c.1444_1446delGAGinsAC frameshift_variant&missense_variant 0.22 pyrazinamide
clpC1 4039268 c.1437C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.22 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039288 p.Leu473Ile missense_variant 0.2 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.28 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039382 c.1323C>T synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.41 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.4 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.4 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039439 c.1266C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.54 pyrazinamide Uncertain significance
clpC1 4039574 c.1129_1131delGCGinsTT frameshift_variant&missense_variant 0.53 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4039581 p.Thr375Ser missense_variant 0.52 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039621 c.1084C>T synonymous_variant 0.55 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.56 pyrazinamide
clpC1 4039646 p.Glu353Ala missense_variant 0.51 pyrazinamide
clpC1 4039715 c.990G>A synonymous_variant 0.28 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.51 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.5 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.48 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.49 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.52 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.52 pyrazinamide
clpC1 4040093 c.610_612delCTCinsTG frameshift_variant&synonymous_variant 0.52 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040138 c.567G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.4 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.4 pyrazinamide
clpC1 4040222 c.483G>A synonymous_variant 0.41 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.46 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.52 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.57 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.55 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.41 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040284 c.421C>T synonymous_variant 0.47 pyrazinamide
clpC1 4040315 c.390G>A synonymous_variant 0.44 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.37 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.36 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.44 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.4 pyrazinamide
clpC1 4040393 c.312G>T synonymous_variant 0.41 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.47 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040477 c.228G>T synonymous_variant 0.33 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.33 pyrazinamide
clpC1 4040486 c.219G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040513 c.192G>A synonymous_variant 0.35 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.29 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>T synonymous_variant 0.26 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.21 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.35 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.38 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.38 pyrazinamide
panD 4044174 c.108C>G synonymous_variant 0.36 pyrazinamide
panD 4044180 c.102C>T synonymous_variant 0.36 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.34 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.34 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.38 pyrazinamide
panD 4044237 c.45G>C synonymous_variant 0.34 pyrazinamide
panD 4044240 c.42G>C synonymous_variant 0.34 pyrazinamide
panD 4044262 p.Lys7Arg missense_variant 0.34 pyrazinamide
panD 4044264 c.18G>C synonymous_variant 0.32 pyrazinamide
panD 4044284 c.-3C>T upstream_gene_variant 0.23 pyrazinamide
panD 4044287 c.-6A>G upstream_gene_variant 0.23 pyrazinamide
panD 4044294 c.-13A>C upstream_gene_variant 0.23 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.18 pyrazinamide
panD 4044728 c.-447C>T upstream_gene_variant 0.19 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.33 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.34 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.34 pyrazinamide
panD 4044758 c.-477C>G upstream_gene_variant 0.34 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.32 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.33 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.32 pyrazinamide
panD 4044796 c.-515G>A upstream_gene_variant 0.31 pyrazinamide
panD 4044812 c.-531A>G upstream_gene_variant 0.31 pyrazinamide
panD 4044817 c.-537_-536insTC upstream_gene_variant 0.3 pyrazinamide
panD 4044820 c.-541_-540delGC upstream_gene_variant 0.31 pyrazinamide
panD 4044830 c.-549C>G upstream_gene_variant 0.27 pyrazinamide
panD 4044833 c.-552A>G upstream_gene_variant 0.27 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.26 pyrazinamide
panD 4044851 c.-570C>G upstream_gene_variant 0.26 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.26 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 0.25 pyrazinamide
glpK 4138541 c.1215C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138547 c.1209C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138580 c.1176C>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.46 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.51 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138658 c.1098C>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>T synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.42 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>A synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138697 c.1059C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138766 c.990G>A synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138832 c.924C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139207 c.549T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139228 c.526_528delCCGinsGC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139231 c.525A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139242 c.514T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139249 c.507C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139255 c.501G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139270 c.486C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139273 c.483A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139276 c.480T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139282 c.474T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139285 p.Glu157Asp missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139297 c.459G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139330 c.426G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139947 c.-192C>A upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240178 c.316T>C synonymous_variant 0.23 ethambutol
embC 4240183 c.321A>G synonymous_variant 0.26 ethambutol
embC 4240204 c.342T>G synonymous_variant 0.25 ethambutol
embC 4240216 c.354T>C synonymous_variant 0.24 ethambutol
embC 4240219 c.357C>G synonymous_variant 0.24 ethambutol
embC 4240229 c.367_369delCTGinsAC frameshift_variant&missense_variant 0.24 ethambutol
embC 4240232 p.Gln124Val missense_variant 0.22 ethambutol
embC 4240237 c.375G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4240244 p.Asp128Asn missense_variant 0.2 ethambutol
embC 4240307 p.Gly149Ser missense_variant 0.22 ethambutol Uncertain significance
embC 4240313 p.Thr151Ala missense_variant 0.22 ethambutol
embC 4240543 c.681G>C synonymous_variant 0.26 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.27 ethambutol
embC 4240574 c.712_714delGTAinsCG frameshift_variant&missense_variant 0.27 ethambutol
embC 4240583 c.721_723delACCinsGG frameshift_variant&missense_variant 0.26 ethambutol
embC 4240587 p.Gly242Ala missense_variant 0.3 ethambutol
embC 4240598 c.736_738delGTGinsAC frameshift_variant&missense_variant 0.31 ethambutol
embC 4240615 c.753G>C synonymous_variant 0.37 ethambutol
embC 4240630 c.768C>G synonymous_variant 0.37 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.37 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.4 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.38 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.47 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.47 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.49 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.52 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.53 ethambutol
embC 4240698 p.Ala279Gly missense_variant 0.56 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
embC 4240738 c.876C>A synonymous_variant 0.6 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.53 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.54 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.54 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.53 ethambutol
embC 4240805 c.943_945delCGCinsAG frameshift_variant&missense_variant 0.55 ethambutol
embC 4240811 p.Phe317Leu missense_variant 0.53 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.52 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.51 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.45 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.42 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.41 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.41 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.41 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.39 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.37 ethambutol
embC 4240897 c.1035C>A synonymous_variant 0.4 ethambutol
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.4 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.41 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.41 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.44 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.39 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.37 ethambutol
embC 4240969 c.1107C>T synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embC 4240978 c.1116G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.33 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.33 ethambutol
embC 4240990 c.1128A>C synonymous_variant 0.37 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.38 ethambutol
embC 4241002 c.1140G>A synonymous_variant 0.38 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.42 ethambutol
embC 4241023 c.1161T>C synonymous_variant 0.43 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.49 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.49 ethambutol
embC 4241053 c.1191G>T synonymous_variant 0.51 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.5 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.51 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.52 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.55 ethambutol Not assoc w R - Interim
embC 4241161 c.1299C>G synonymous_variant 0.51 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.5 ethambutol
embC 4241188 c.1326C>G synonymous_variant 0.45 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.44 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.31 ethambutol
embC 4241998 c.2136G>C synonymous_variant 0.22 ethambutol
embC 4242002 p.Leu714Val missense_variant 0.25 ethambutol
embC 4242011 c.2149_2151delCTTinsGG frameshift_variant&missense_variant 0.27 ethambutol
embC 4242024 p.Val721Ala missense_variant 0.28 ethambutol
embC 4242036 p.Gln725Leu missense_variant 0.27 ethambutol
embC 4242045 p.Ile728Thr missense_variant 0.25 ethambutol
embC 4242047 p.Ser729Asp missense_variant 0.24 ethambutol
embC 4242055 c.2193C>T synonymous_variant 0.24 ethambutol
embC 4242070 c.2208T>C synonymous_variant 0.25 ethambutol
embC 4242073 c.2211C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4242076 c.2214G>C synonymous_variant 0.23 ethambutol
embC 4242079 c.2217T>C synonymous_variant 0.24 ethambutol
embC 4242085 c.2223A>G synonymous_variant 0.25 ethambutol
embC 4242095 p.Ala745Thr missense_variant 0.27 ethambutol Uncertain significance
embC 4242100 c.2238C>G synonymous_variant 0.29 ethambutol
embC 4242104 c.2242_2244delACCinsTG frameshift_variant&missense_variant 0.29 ethambutol
embC 4242138 p.Leu759Gln missense_variant 0.37 ethambutol
embC 4242142 c.2280T>C synonymous_variant 0.33 ethambutol
embC 4242151 c.2289A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4242154 c.2292C>G synonymous_variant 0.23 ethambutol
embC 4242161 p.Ala767Thr missense_variant 0.23 ethambutol
embC 4242171 p.Thr770Asn missense_variant 0.23 ethambutol
embC 4242173 p.Ala771Thr missense_variant 0.24 ethambutol Uncertain significance
embC 4242176 c.2314_2316delCCGinsTA frameshift_variant&stop_gained 0.25 ethambutol
embC 4242179 c.2317_2319delTTGinsGC frameshift_variant&missense_variant 0.25 ethambutol
embC 4242190 c.2328C>A synonymous_variant 0.23 ethambutol
embC 4242196 c.2334A>C synonymous_variant 0.24 ethambutol
embC 4242199 c.2337C>G synonymous_variant 0.24 ethambutol
embC 4242202 c.2340C>T synonymous_variant 0.24 ethambutol
embC 4242220 c.2358A>G synonymous_variant 0.21 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4244372 c.1140T>G synonymous_variant 0.2 ethambutol
embA 4244378 c.1146G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embA 4244534 c.1302T>C synonymous_variant 0.24 ethambutol
embA 4244537 c.1305T>G synonymous_variant 0.31 ethambutol
embA 4244543 c.1311C>G synonymous_variant 0.32 ethambutol
embA 4244547 p.Ile439Val missense_variant 0.36 ethambutol
embA 4244557 p.Arg442Thr missense_variant 0.4 ethambutol
embA 4244561 c.1329C>T synonymous_variant 0.44 ethambutol
embA 4244582 c.1350T>C synonymous_variant 0.5 ethambutol
embA 4244585 c.1353A>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embA 4244594 c.1362G>A synonymous_variant 0.53 ethambutol
embA 4244612 c.1380C>G synonymous_variant 0.53 ethambutol
embA 4244615 c.1383G>C synonymous_variant 0.52 ethambutol
embA 4244616 p.Ala462Ser missense_variant 0.51 ethambutol
embA 4244619 c.1387T>C synonymous_variant 0.53 ethambutol
embA 4244631 p.Thr467Leu missense_variant 0.51 ethambutol
embA 4244645 c.1413T>C synonymous_variant 0.54 ethambutol
embA 4244648 c.1416G>C synonymous_variant 0.54 ethambutol
embA 4244650 p.Asp473Gly missense_variant 0.54 ethambutol Uncertain significance
embA 4244663 c.1431C>A synonymous_variant 0.52 ethambutol
embA 4244669 c.1437G>C synonymous_variant 0.49 ethambutol
embA 4244671 p.Ala480Gly missense_variant 0.49 ethambutol
embA 4244681 c.1449A>C synonymous_variant 0.47 ethambutol
embA 4244720 c.1488C>T synonymous_variant 0.3 ethambutol
embA 4244728 p.Phe499Trp missense_variant 0.23 ethambutol
embA 4244948 c.1716G>C synonymous_variant 0.2 ethambutol
embA 4244960 c.1728A>G synonymous_variant 0.26 ethambutol
embA 4244980 p.Val583Ala missense_variant 0.33 ethambutol
embA 4244982 c.1750T>C synonymous_variant 0.33 ethambutol
embA 4245003 p.Thr591Ala missense_variant 0.38 ethambutol Uncertain significance
embA 4245006 c.1774_1776delTTTinsCG frameshift_variant&missense_variant 0.39 ethambutol Uncertain significance
embA 4245014 c.1782C>G synonymous_variant 0.39 ethambutol
embA 4245020 c.1788T>C synonymous_variant 0.35 ethambutol
embA 4245026 c.1794T>C synonymous_variant 0.35 ethambutol
embA 4245028 p.Ser599Asn missense_variant 0.39 ethambutol
embA 4245032 c.1800A>C synonymous_variant 0.4 ethambutol
embA 4245041 c.1809C>G synonymous_variant 0.4 ethambutol
embA 4245056 c.1824C>G synonymous_variant 0.43 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.44 ethambutol
embA 4245072 p.Leu614Val missense_variant 0.42 ethambutol
embA 4245078 p.Trp616Val missense_variant 0.38 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embA 4245093 p.Ile621Val missense_variant 0.4 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.39 ethambutol
embA 4245125 c.1893G>T synonymous_variant 0.43 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.47 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.46 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.43 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.44 ethambutol
embA 4245198 p.Leu656Ala missense_variant 0.42 ethambutol
embA 4245206 c.1974A>C synonymous_variant 0.43 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.43 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.43 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.43 ethambutol Uncertain significance
embA 4245257 c.2025A>G synonymous_variant 0.29 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4245632 c.-882C>T upstream_gene_variant 0.2 ethambutol
embB 4245644 c.-870C>G upstream_gene_variant 0.26 ethambutol
embA 4245650 p.Ile806Met missense_variant 0.28 ethambutol
embA 4245652 p.Thr807Ser missense_variant 0.28 ethambutol
embB 4245668 c.-846C>G upstream_gene_variant 0.3 ethambutol
embA 4245674 c.2442A>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4245686 c.-828G>C upstream_gene_variant 0.23 ethambutol
embA 4245728 p.Leu832Phe missense_variant 0.27 ethambutol Uncertain significance
embB 4245737 c.-777A>C upstream_gene_variant 0.37 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.36 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.34 ethambutol
embA 4245772 p.Asn847Thr missense_variant 0.32 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4246262 c.-252C>T upstream_gene_variant 0.24 ethambutol
embA 4246278 p.Ala1016Ser missense_variant 0.33 ethambutol Uncertain significance
embA 4246290 p.Leu1020Gly missense_variant 0.29 ethambutol
embA 4246299 p.Ser1023Ala missense_variant 0.29 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.29 ethambutol
embB 4246313 c.-201C>T upstream_gene_variant 0.31 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.28 ethambutol
embA 4246329 p.Thr1033Leu missense_variant 0.28 ethambutol
embA 4246335 c.3103_3105delGCGinsAA frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
embA 4246338 p.Leu1036Met missense_variant 0.26 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
embB 4246367 c.-147C>T upstream_gene_variant 0.26 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.26 ethambutol
embB 4246400 c.-114G>C upstream_gene_variant 0.2 ethambutol
embB 4247370 p.Gly286Ala missense_variant 0.2 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.25 ethambutol
embB 4247380 c.867C>G synonymous_variant 0.29 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.32 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.33 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.33 ethambutol
embB 4247404 c.891G>C synonymous_variant 0.33 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embB 4247464 c.951C>G synonymous_variant 0.34 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.39 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.42 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.46 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.45 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.4 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.36 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.35 ethambutol
embB 4247567 c.1054C>T synonymous_variant 0.35 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.35 ethambutol
embB 4247576 c.1063C>T synonymous_variant 0.36 ethambutol
embB 4247579 p.Ala356Ile missense_variant 0.36 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.35 ethambutol
embB 4247608 c.1095G>C synonymous_variant 0.36 ethambutol
embB 4247621 c.1108C>T synonymous_variant 0.28 ethambutol
embB 4247629 c.1116C>G synonymous_variant 0.24 ethambutol
embB 4247635 c.1122G>A synonymous_variant 0.22 ethambutol
embB 4247638 c.1125G>C synonymous_variant 0.22 ethambutol
embB 4247776 c.1263G>C synonymous_variant 0.31 ethambutol
embB 4247779 c.1266C>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4247785 c.1272G>C synonymous_variant 0.35 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.37 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.35 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.35 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.36 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.36 ethambutol
embB 4247827 c.1314C>G synonymous_variant 0.37 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.4 ethambutol
embB 4247851 c.1338C>T synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embB 4247857 c.1344C>T synonymous_variant 0.48 ethambutol
embB 4247858 c.1345C>T synonymous_variant 0.48 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.51 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.52 ethambutol Not assoc w R - Interim
embB 4247899 p.Met462Ile missense_variant 0.51 ethambutol
embB 4247905 c.1392G>T synonymous_variant 0.45 ethambutol
embB 4247908 c.1395C>T synonymous_variant 0.44 ethambutol
embB 4247909 c.1396T>C synonymous_variant 0.44 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4247940 p.Leu476Trp missense_variant 0.4 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.41 ethambutol
embB 4247951 c.1438_1440delTCGinsGT frameshift_variant&missense_variant 0.43 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
embB 4247965 c.1452C>G synonymous_variant 0.47 ethambutol
embB 4247968 c.1455C>A synonymous_variant 0.46 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.47 ethambutol
embB 4247992 c.1479G>A synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.48 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.42 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.41 ethambutol Uncertain significance
embB 4248044 p.Lys511Ser missense_variant 0.42 ethambutol
embB 4248052 c.1539G>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>C synonymous_variant 0.43 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.45 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.46 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.43 ethambutol
embB 4248100 c.1587C>T synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4248109 c.1596C>A synonymous_variant 0.42 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.4 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.37 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.37 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.35 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.35 ethambutol
embB 4248146 p.Ile545Val missense_variant 0.35 ethambutol
embB 4248149 p.Thr546Ala missense_variant 0.36 ethambutol Uncertain significance
embB 4248157 c.1644A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embB 4248163 c.1650G>C synonymous_variant 0.4 ethambutol
embB 4248169 c.1656C>G synonymous_variant 0.41 ethambutol
embB 4248175 c.1662G>T synonymous_variant 0.43 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.44 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.44 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.44 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.47 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.5 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.51 ethambutol
embB 4248226 c.1713G>C synonymous_variant 0.51 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.47 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.44 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.44 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.28 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.27 ethambutol
embB 4248322 c.1809G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
aftB 4267464 p.Asn458Ile missense_variant 0.2 ethambutol
aftB 4267469 c.1368C>T synonymous_variant 0.22 ethambutol
aftB 4267484 c.1353A>G synonymous_variant 0.21 ethambutol
aftB 4267489 c.1348T>C synonymous_variant 0.22 ethambutol
aftB 4267493 c.1344G>C synonymous_variant 0.23 ethambutol
aftB 4267499 c.1338G>C synonymous_variant 0.24 ethambutol
aftB 4267514 c.1323G>C synonymous_variant 0.24 ethambutol
aftB 4267517 c.1320A>C synonymous_variant 0.26 ethambutol
aftB 4267520 c.1317T>G synonymous_variant 0.24 ethambutol
aftB 4267523 c.1312_1314delGTGinsAC frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
aftB 4267529 c.1308T>G synonymous_variant 0.26 ethambutol
aftB 4267535 c.1302A>G synonymous_variant 0.26 ethambutol
aftB 4267544 p.Asp431Gly missense_variant 0.23 ethambutol
aftB 4267547 c.1290C>G synonymous_variant 0.25 ethambutol
aftB 4267579 p.His420Asn missense_variant 0.25 ethambutol
aftB 4267580 c.1257G>C synonymous_variant 0.26 ethambutol
aftB 4267594 p.Ala415Ser missense_variant 0.24 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
aftB 4268084 c.753G>C synonymous_variant 0.2 ethambutol
aftB 4268117 c.720G>C synonymous_variant 0.27 ethambutol
aftB 4268123 c.712_714delAGTinsGC frameshift_variant&synonymous_variant 0.27 ethambutol Uncertain significance
aftB 4268129 c.708T>A synonymous_variant 0.27 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.28 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.36 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.36 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.35 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.35 ethambutol
aftB 4268194 p.Leu215Val missense_variant 0.36 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.2 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.22 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.28 ethambutol
ubiA 4269075 c.757_759delATTinsGG frameshift_variant&missense_variant 0.33 ethambutol
ubiA 4269080 p.Met252Leu missense_variant 0.33 ethambutol
ubiA 4269091 p.Phe248Tyr missense_variant 0.34 ethambutol
aftB 4269096 c.-260C>G upstream_gene_variant 0.33 ethambutol
aftB 4269102 c.-268_-266delAGCinsTCG upstream_gene_variant 0.31 ethambutol
ubiA 4269107 p.Tyr243His missense_variant 0.32 ethambutol
ubiA 4269109 p.Gly242His missense_variant 0.32 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.34 ethambutol
aftB 4269132 c.-296G>C upstream_gene_variant 0.36 ethambutol
ubiA 4269141 c.691_693delTTGinsAT frameshift_variant&missense_variant 0.35 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
aftB 4269153 c.-317C>G upstream_gene_variant 0.36 ethambutol
aftB 4269156 c.-320C>G upstream_gene_variant 0.36 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.37 ethambutol
aftB 4269177 c.-341G>T upstream_gene_variant 0.35 ethambutol
aftB 4269186 c.-350C>A upstream_gene_variant 0.31 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.23 ethambutol
aftB 4269204 c.-368G>C upstream_gene_variant 0.22 ethambutol
aftB 4269210 c.-374G>A upstream_gene_variant 0.22 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.23 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4269234 c.-398A>G upstream_gene_variant 0.27 ethambutol
ubiA 4269240 c.592_594delCTGinsGC frameshift_variant&missense_variant 0.26 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.24 ethambutol
aftB 4269267 c.-431C>G upstream_gene_variant 0.29 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338794 c.-273A>G upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.96 streptomycin Not assoc w R