TB-Profiler result

Run: ERR4799513
Summary

Run ID: ERR4799513

Sample name:

Date: 2024-03-27T00:54:13.910142

Number of reads: 1417038

Percentage reads mapped: 40.09

Median coverage: 29.0

Strain: lineage2.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.2 Indo-Oceanic RD239 0.81
lineage2 East-Asian RD105 0.07
lineage1.2.2.2 Indo-Oceanic RD239 0.73
lineage2.2 East-Asian (Beijing) RD105;RD207 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid kasA p.Arg121Lys Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ofloxacin
levofloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine pepQ c.639_641delGGTinsC Assoc w R - Interim
c.592_594delGCCinsCG Assoc w R - Interim
para-aminosalicylic_acid
delamanid fgd1 c.766_768delGCTinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.751_753delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2344_2346delTCGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.639_641delGGTinsC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.592_594delGCCinsCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6738 p.Thr500Asn missense_variant 0.48 levofloxacin Uncertain significance Mutation from literature
moxifloxacin Uncertain significance Mutation from literature
fgd1 491548 c.766_768delGCTinsCC frameshift_variant&missense_variant 0.42 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.48 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303681 c.751_753delTTGinsCC frameshift_variant&missense_variant 0.24 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305274 c.2344_2346delTCGinsCC frameshift_variant&missense_variant 0.32 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.33 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
kasA 2518476 p.Arg121Lys missense_variant 0.36 isoniazid Mutation from literature
pepQ 2859778 c.639_641delGGTinsC frameshift_variant&missense_variant 0.32 clofazimine Assoc w R - Interim
bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
pepQ 2859825 c.592_594delGCCinsCG frameshift_variant&synonymous_variant 0.22 clofazimine Assoc w R - Interim
bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 510 c.510T>G synonymous_variant 0.32 isoniazid
dnaA 522 c.522T>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 525 c.525T>C synonymous_variant 0.33 isoniazid
dnaA 528 c.528G>C synonymous_variant 0.36 isoniazid
dnaA 534 c.534T>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 540 c.540C>T synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 541 p.Ala181Thr missense_variant 0.35 isoniazid
dnaA 567 c.567C>T synonymous_variant 0.36 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.34 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.35 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.35 isoniazid
dnaA 588 c.588A>G synonymous_variant 0.38 isoniazid
dnaA 594 c.594C>G synonymous_variant 0.38 isoniazid
dnaA 597 c.597C>T synonymous_variant 0.38 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.37 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.35 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.35 isoniazid
dnaA 624 c.624C>T synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 636 c.636C>G synonymous_variant 0.36 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.32 isoniazid
gyrB 5075 c.-165C>T upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.87 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6170 p.His311Ala missense_variant 0.5 levofloxacin
moxifloxacin
gyrB 6178 c.939C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6196 c.957C>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6203 c.964_966delAGCinsTCG synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAGC synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6229 c.990G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.38 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6283 p.Asp348Glu missense_variant 0.43 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6324 c.1085_1086insGTCC frameshift_variant 0.26 levofloxacin Uncertain significance
moxifloxacin
gyrB 6327 c.1090_1093delGAAC frameshift_variant 0.29 levofloxacin Uncertain significance
moxifloxacin
gyrB 6358 c.1119C>G synonymous_variant 0.29 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6361 c.-941G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>T upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6730 c.-572A>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6787 c.-515G>A upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Ser missense_variant 0.46 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6860 c.1621_1623delTCCinsGG frameshift_variant&missense_variant 0.49 levofloxacin Uncertain significance
moxifloxacin
gyrA 6865 c.-437G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>T upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>A upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>T upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6922 c.1683G>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrB 7047 p.Lys603Thr missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7075 c.-227T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7114 c.-188C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7159 c.1920C>T synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 7178 c.1939_1941delTTGinsCC frameshift_variant&missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7210 p.Asp657Glu missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7231 c.-71C>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7268 c.-34C>T upstream_gene_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7460 c.159C>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7502 c.201C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7511 c.210C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7748 c.447A>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7758 p.Ile153Val missense_variant 0.62 levofloxacin Uncertain significance
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7889 c.588G>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 7911 p.Ala204Cys missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7922 c.621T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Val missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8318 c.1017C>G synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.71 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8366 c.1065G>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>A synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.74 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.72 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8417 c.1116C>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.32 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8459 c.1158G>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8534 c.1233G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8813 c.1512C>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.68 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8981 c.1680G>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.67 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9014 c.1713C>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9063 p.Ser588Leu missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.82 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9161 c.1860C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9224 c.1923C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9242 c.1941A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.48 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9266 p.Asp655Glu missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 0.98 levofloxacin
moxifloxacin
gyrA 9308 c.2007C>T synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9332 c.2031C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
Rv0010c 13298 p.Ile87Met missense_variant 0.72 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.72 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 0.75 isoniazid Not assoc w R
Rv0010c 13699 c.-141A>G upstream_gene_variant 0.91 isoniazid Not assoc w R
fgd1 491184 c.402A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491223 c.441C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491229 c.447C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491248 p.Arg156Asn missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491262 c.480C>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.55 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.56 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491307 c.525C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491320 p.Ala180Thr missense_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491328 c.546C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491334 c.552C>T synonymous_variant 0.48 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.48 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491382 c.600G>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491412 c.630G>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491415 c.633A>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491418 c.636A>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491421 c.639A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491424 c.642C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491427 c.645C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491430 c.648T>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491436 c.654T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491439 p.Asp219Glu missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491443 p.Ser221Asp missense_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491453 p.Gly224Ala missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491493 c.711C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491503 c.721C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_782delAGinsTC synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>T synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 0.92 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575545 c.198C>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575548 c.201C>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.39 ethionamide
isoniazid
mshA 575569 c.222A>G synonymous_variant 0.4 ethionamide
isoniazid
mshA 575572 c.225T>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575596 c.249C>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575597 c.250_252delATCinsGG frameshift_variant&missense_variant 0.41 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575601 p.Glu85Ala missense_variant 0.42 ethionamide Uncertain significance
isoniazid
mshA 575626 c.279C>G synonymous_variant 0.47 ethionamide
isoniazid
mshA 575627 p.Ala94Ser missense_variant 0.47 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.41 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.34 ethionamide
isoniazid
mshA 575652 p.Arg102His missense_variant 0.35 ethionamide
isoniazid
mshA 575656 c.309G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575659 c.312A>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.41 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.46 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.43 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.41 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.44 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575714 p.Tyr123Asn missense_variant 0.51 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.63 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.63 ethionamide
isoniazid
mshA 575749 c.402C>G synonymous_variant 0.66 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.66 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.65 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.65 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.66 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.65 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.67 ethionamide
isoniazid
mshA 575795 c.448_450delATCinsGA frameshift_variant&missense_variant 0.66 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575812 c.465C>T synonymous_variant 0.72 ethionamide
isoniazid
mshA 575818 c.471G>C synonymous_variant 0.71 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.68 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.69 ethionamide
isoniazid
mshA 575843 p.Arg166Ala missense_variant 0.69 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.7 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.63 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.66 ethionamide
isoniazid
mshA 575892 p.Ala182Gly missense_variant 0.66 ethionamide
isoniazid
mshA 575908 c.561A>C synonymous_variant 0.61 ethionamide
isoniazid Not assoc w R - Interim
mshA 575916 p.Asp190Ala missense_variant 0.6 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.56 ethionamide
isoniazid
mshA 575924 c.577_579delGGAinsAC frameshift_variant&missense_variant 0.57 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575939 c.592C>T synonymous_variant 0.59 ethionamide
isoniazid
mshA 575944 c.597T>G synonymous_variant 0.55 ethionamide
isoniazid
mshA 575945 p.Thr200Ala missense_variant 0.55 ethionamide
isoniazid
mshA 575953 c.606G>T synonymous_variant 0.51 ethionamide
isoniazid
mshA 575965 c.618C>G synonymous_variant 0.45 ethionamide
isoniazid Not assoc w R - Interim
mshA 575980 c.633T>C synonymous_variant 0.41 ethionamide
isoniazid
ccsA 620340 c.450C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620341 c.451_453delGTGinsAC frameshift_variant&missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620358 c.468C>T synonymous_variant 0.31 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620361 c.471C>T synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620366 p.Asn159Thr missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620409 c.519C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.33 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620418 c.528G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620431 p.Leu181Ile missense_variant 0.27 capreomycin
amikacin
kanamycin
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.79 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 0.8 rifampicin Not assoc w R
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.38 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.52 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.51 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.62 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.68 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.68 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.68 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.74 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>C synonymous_variant 0.79 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.63 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.65 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.49 rifampicin
nusG 734614 c.361_363delGCCinsTG frameshift_variant&missense_variant 0.4 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.33 rifampicin
nusG 734787 c.534T>G synonymous_variant 0.36 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.43 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.5 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.41 rifampicin
nusG 734841 c.588G>C synonymous_variant 0.44 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.43 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.42 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.42 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.42 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.42 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.42 rifampicin
nusG 734868 c.615C>T synonymous_variant 0.41 rifampicin
nusG 734869 c.616_617delAGinsTC synonymous_variant 0.41 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.48 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.48 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.41 rifampicin
nusG 734922 c.669C>T synonymous_variant 0.4 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.37 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.51 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>G synonymous_variant 0.57 rifampicin
rpoB 760130 c.324T>C synonymous_variant 0.61 rifampicin
rpoB 760139 c.333A>C synonymous_variant 0.64 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.64 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.62 rifampicin
rpoB 760155 p.Lys117Arg missense_variant 0.64 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.71 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.69 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.72 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.6 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.57 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.56 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.62 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760354 p.Glu183Ala missense_variant 0.48 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.45 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.56 rifampicin Uncertain significance
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.55 rifampicin
rpoB 760407 c.601_603delAGCinsGA frameshift_variant&missense_variant 0.53 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760433 c.627C>T synonymous_variant 0.56 rifampicin
rpoB 760449 p.Thr215Leu missense_variant 0.56 rifampicin
rpoB 760460 c.654G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>G synonymous_variant 0.62 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>T synonymous_variant 0.62 rifampicin Not assoc w R
rpoB 760527 p.Gln241Ala missense_variant 0.55 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Arg missense_variant 0.54 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.56 rifampicin Uncertain significance
rpoB 760587 p.Thr261Ala missense_variant 0.61 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.6 rifampicin
rpoB 760593 p.Gly263Asn missense_variant 0.6 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>T synonymous_variant 0.58 rifampicin
rpoB 760649 c.843G>C synonymous_variant 0.56 rifampicin
rpoB 760654 p.Lys283Arg missense_variant 0.53 rifampicin
rpoB 760661 c.855A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.56 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.26 rifampicin
rpoB 760880 c.1074G>C synonymous_variant 0.29 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.29 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.29 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.29 rifampicin Uncertain significance
rpoB 760916 c.1110C>G synonymous_variant 0.55 rifampicin
rpoB 760919 c.1113C>A synonymous_variant 0.55 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.57 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.59 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.72 rifampicin Uncertain significance
rpoB 760973 c.1167G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.8 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.9 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>T synonymous_variant 0.94 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.94 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.94 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.94 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>A synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>G synonymous_variant 0.84 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.83 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.82 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.81 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.81 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.79 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.83 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.67 rifampicin
rpoB 761289 p.Ser495Ala missense_variant 0.63 rifampicin
rpoB 761292 p.Val496Thr missense_variant 0.63 rifampicin
rpoB 761309 c.1503C>T synonymous_variant 0.61 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.59 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.64 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.62 rifampicin
rpoB 761366 c.1560C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761375 c.1569G>C synonymous_variant 0.5 rifampicin
rpoB 761396 c.1590G>A synonymous_variant 0.44 rifampicin
rpoB 761403 p.His533Tyr missense_variant 0.45 rifampicin
rpoB 761406 c.1600_1602delGTGinsAC frameshift_variant&missense_variant 0.45 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.5 rifampicin
rpoB 761430 c.1624_1626delATCinsCG frameshift_variant&missense_variant 0.5 rifampicin
rpoB 761435 p.Asp543Glu missense_variant 0.52 rifampicin
rpoB 761437 p.Ala544Gly missense_variant 0.52 rifampicin
rpoB 761451 p.Val549Thr missense_variant 0.48 rifampicin
rpoB 761457 p.Pro551Glu missense_variant 0.48 rifampicin
rpoB 761474 c.1668C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761477 c.1671C>T synonymous_variant 0.53 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.52 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.62 rifampicin
rpoB 761502 c.1696_1698delCCCinsTG frameshift_variant&missense_variant 0.57 rifampicin
rpoB 761508 c.1702_1704delTCTinsGC frameshift_variant&missense_variant 0.55 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.62 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.75 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.8 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.68 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>T synonymous_variant 0.69 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.7 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.68 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.65 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.65 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.56 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761747 c.1941G>C synonymous_variant 0.65 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.65 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.62 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.64 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.67 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.67 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.73 rifampicin
rpoB 761814 p.Ala670Asn missense_variant 0.73 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.66 rifampicin
rpoB 761847 c.2041_2043delTGCinsCG frameshift_variant&missense_variant 0.62 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.62 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.61 rifampicin
rpoB 761861 c.2055C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761864 c.2058G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.6 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 0.63 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.65 rifampicin
rpoB 761897 c.2091C>G synonymous_variant 0.66 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.65 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.61 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.61 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.64 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.69 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAG frameshift_variant&missense_variant 0.64 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.58 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.77 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.77 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.78 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.78 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.75 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.75 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>T synonymous_variant 0.75 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.64 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.68 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.65 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.67 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.63 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.63 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.63 rifampicin
rpoC 762377 c.-993C>T upstream_gene_variant 0.63 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.61 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.55 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.54 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.59 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Ala missense_variant 0.66 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.57 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.57 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.59 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.59 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.56 rifampicin
rpoC 762557 c.-813G>C upstream_gene_variant 0.54 rifampicin
rpoC 762560 c.-810A>T upstream_gene_variant 0.52 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.49 rifampicin
rpoC 762575 c.-795C>T upstream_gene_variant 0.43 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.7 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.36 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763049 c.-321G>A upstream_gene_variant 0.71 rifampicin
rpoC 763058 c.-312C>G upstream_gene_variant 0.74 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.72 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.64 rifampicin
rpoC 763178 c.-192G>A upstream_gene_variant 0.64 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.55 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.55 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.54 rifampicin Uncertain significance
rpoB 763214 c.3408T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763227 c.3421C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763262 c.-108C>A upstream_gene_variant 0.33 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.33 rifampicin
rpoC 763396 c.27A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763409 c.40_42delCTTinsTG frameshift_variant&missense_variant 0.45 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.72 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763687 c.318C>T synonymous_variant 0.61 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.56 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.56 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.46 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.47 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.42 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763867 c.498C>G synonymous_variant 0.38 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.38 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.4 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.4 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.52 rifampicin Not assoc w R
rpoC 763886 c.517_519delCGGinsAT frameshift_variant&missense_variant 0.53 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.41 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.41 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.48 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.54 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.53 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.57 rifampicin Uncertain significance
rpoC 763951 c.582G>A synonymous_variant 0.57 rifampicin
rpoC 763969 c.600C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.68 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.68 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.66 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.67 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.65 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.65 rifampicin
rpoC 764030 p.Asp221Asn missense_variant 0.65 rifampicin Uncertain significance
rpoC 764039 p.Ser224Asp missense_variant 0.6 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.61 rifampicin
rpoC 764048 p.Thr227Val missense_variant 0.61 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.65 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.62 rifampicin
rpoC 764085 p.Asn239Thr missense_variant 0.61 rifampicin Uncertain significance
rpoC 764087 p.Leu240Val missense_variant 0.62 rifampicin Uncertain significance
rpoC 764098 c.729A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.7 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.73 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Thr missense_variant 0.73 rifampicin Uncertain significance
rpoC 764213 p.Arg282Lys missense_variant 0.72 rifampicin Uncertain significance
rpoC 764242 c.873C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.75 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.77 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.73 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.74 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.72 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.71 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.72 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066A>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.73 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.73 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.74 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.83 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.74 rifampicin
rpoC 764635 c.1266C>G synonymous_variant 0.64 rifampicin
rpoC 764638 c.1269C>T synonymous_variant 0.63 rifampicin
rpoC 764644 c.1275G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764647 c.1278C>T synonymous_variant 0.56 rifampicin
rpoC 764650 c.1281G>C synonymous_variant 0.56 rifampicin
rpoC 764653 c.1284G>C synonymous_variant 0.53 rifampicin
rpoC 764656 c.1287C>T synonymous_variant 0.53 rifampicin
rpoC 764659 c.1290C>T synonymous_variant 0.53 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.55 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.68 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.74 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.74 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.76 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.77 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.75 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.75 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.68 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.63 rifampicin
rpoC 765037 c.1668C>G synonymous_variant 0.6 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>A synonymous_variant 0.53 rifampicin
rpoC 765082 c.1713G>T synonymous_variant 0.54 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765121 c.1752G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765129 p.Tyr587Phe missense_variant 0.27 rifampicin
rpoC 765359 p.Ala664Thr missense_variant 0.45 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.62 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.62 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.62 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.62 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.67 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.64 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.63 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.63 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.67 rifampicin
rpoC 765607 c.2238C>G synonymous_variant 0.68 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.68 rifampicin Uncertain significance
rpoC 765628 c.2259G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.68 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765718 p.Asp783Glu missense_variant 0.79 rifampicin Uncertain significance
rpoC 765724 c.2355C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.72 rifampicin
rpoC 765742 p.Glu791Asp missense_variant 0.71 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.72 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.73 rifampicin Uncertain significance
rpoC 765787 c.2418C>T synonymous_variant 0.72 rifampicin
rpoC 765790 c.2421C>G synonymous_variant 0.72 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.72 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.74 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765823 c.2454C>G synonymous_variant 0.76 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.71 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.74 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.74 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Gly missense_variant 0.62 rifampicin
rpoC 766061 c.2692_2694delGTCinsCG frameshift_variant&missense_variant 0.4 rifampicin
rpoC 766066 c.2697C>G synonymous_variant 0.39 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.38 rifampicin
rpoC 766079 p.Arg904Val missense_variant 0.33 rifampicin
rpoC 766084 c.2715A>T synonymous_variant 0.37 rifampicin
rpoC 766093 c.2724C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766094 p.Thr909Ser missense_variant 0.29 rifampicin
rpoC 766097 c.2728C>T synonymous_variant 0.29 rifampicin
rpoC 766113 p.Tyr915Phe missense_variant 0.27 rifampicin
rpoC 766120 c.2751A>G synonymous_variant 0.23 rifampicin
rpoC 766258 c.2889T>G synonymous_variant 0.44 rifampicin
rpoC 766270 c.2901G>C synonymous_variant 0.56 rifampicin
rpoC 766280 c.2911_2913delAGCinsGA frameshift_variant&missense_variant 0.61 rifampicin
rpoC 766291 c.2922G>C synonymous_variant 0.66 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.64 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.64 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.63 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.62 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.64 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.64 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.64 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.69 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.71 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.71 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.71 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.69 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.69 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.75 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.74 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.72 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.7 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.7 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.65 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.64 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.64 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.67 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.66 rifampicin
rpoC 766607 c.3238_3240delATCinsTG frameshift_variant&missense_variant 0.66 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.65 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.68 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.66 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.65 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.64 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.65 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.65 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.68 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.69 rifampicin
rpoC 766693 c.3324C>A synonymous_variant 0.68 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.68 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.68 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.7 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.67 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.56 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.56 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.56 rifampicin
rpoC 766783 c.3414C>T synonymous_variant 0.59 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.6 rifampicin Uncertain significance
rpoC 766804 c.3435A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.73 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.7 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.71 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.7 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.67 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.69 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.69 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.71 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.71 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>G synonymous_variant 0.59 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767030 c.3661C>T synonymous_variant 0.53 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.54 rifampicin
rpoC 767059 c.3690T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767102 c.3733_3735delCTCinsTG frameshift_variant&missense_variant 0.65 rifampicin
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.67 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 767191 c.3822C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>T synonymous_variant 0.77 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767266 c.3897G>C synonymous_variant 0.41 rifampicin
rpoC 767272 c.3903C>T synonymous_variant 0.41 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.38 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.37 rifampicin
rpoC 767302 c.3933C>G synonymous_variant 0.33 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775817 c.2664T>C synonymous_variant 0.21 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775832 c.2649C>T synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 775850 c.2631C>T synonymous_variant 0.41 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.41 clofazimine
bedaquiline
mmpL5 775862 c.2619G>C synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.41 clofazimine
bedaquiline
mmpL5 775871 p.Ile870Met missense_variant 0.4 clofazimine
bedaquiline
mmpL5 775882 p.Asn867His missense_variant 0.4 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsCG frameshift_variant&missense_variant 0.4 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>G synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775901 c.2580G>A synonymous_variant 0.45 clofazimine
bedaquiline
mmpL5 775905 p.Lys859Arg missense_variant 0.42 clofazimine
bedaquiline
mmpL5 775913 c.2566_2568delGCCinsTG frameshift_variant&missense_variant 0.45 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775916 c.2565T>G synonymous_variant 0.45 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 775954 c.2527C>T synonymous_variant 0.38 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775961 c.2520C>G synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775970 c.2511G>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.2 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.41 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.42 streptomycin
rpsL 781649 c.90T>G synonymous_variant 0.51 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.54 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.53 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.61 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.62 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.62 streptomycin
rpsL 781718 c.159C>T synonymous_variant 0.62 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.61 streptomycin
rpsL 781726 p.Lys56Arg missense_variant 0.6 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.6 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.6 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.58 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.59 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.59 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.6 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.62 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.62 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.7 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.71 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.68 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.65 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.6 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.6 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.6 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.61 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.62 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.59 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.59 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.49 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 0.83 linezolid Not assoc w R
rplC 800498 c.-311G>A upstream_gene_variant 0.23 linezolid
rplC 800516 c.-293G>C upstream_gene_variant 0.41 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.55 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.57 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.58 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.57 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.58 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.57 linezolid
rplC 800588 c.-221C>G upstream_gene_variant 0.6 linezolid
rplC 800589 c.-220_-219delAGinsTC upstream_gene_variant 0.6 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.58 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.58 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.61 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.62 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.62 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.61 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.61 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.6 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.53 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.5 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.49 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.5 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.51 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.42 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.42 linezolid
rplC 800892 c.84G>C synonymous_variant 0.33 linezolid
rplC 800916 c.108A>G synonymous_variant 0.54 linezolid
rplC 800931 c.123G>C synonymous_variant 0.61 linezolid
rplC 800937 c.129A>G synonymous_variant 0.61 linezolid
rplC 800946 c.138T>C synonymous_variant 0.57 linezolid
rplC 800950 c.142_144delAGCinsTCG synonymous_variant 0.57 linezolid
rplC 800964 c.156G>C synonymous_variant 0.58 linezolid
rplC 800970 c.162T>C synonymous_variant 0.57 linezolid Not assoc w R - Interim
rplC 800985 c.177A>T synonymous_variant 0.55 linezolid
rplC 801153 c.345G>C synonymous_variant 0.37 linezolid
rplC 801156 c.348T>C synonymous_variant 0.39 linezolid
rplC 801171 c.363A>G synonymous_variant 0.46 linezolid
rplC 801174 c.366T>C synonymous_variant 0.44 linezolid
rplC 801176 p.Phe123Tyr missense_variant 0.46 linezolid
rplC 801205 p.Arg133Ala missense_variant 0.55 linezolid
rplC 801210 c.402T>G synonymous_variant 0.55 linezolid Not assoc w R - Interim
rplC 801220 c.412_414delAGTinsGG frameshift_variant&missense_variant 0.55 linezolid
rplC 801228 c.420T>C synonymous_variant 0.53 linezolid
rplC 801231 c.423C>T synonymous_variant 0.53 linezolid
rplC 801249 c.441T>G synonymous_variant 0.54 linezolid
rplC 801255 c.447C>T synonymous_variant 0.52 linezolid
rplC 801258 c.450C>G synonymous_variant 0.49 linezolid
rplC 801267 c.459A>C synonymous_variant 0.46 linezolid
rplC 801270 c.462T>C synonymous_variant 0.46 linezolid
rplC 801271 c.463_465delGCCinsTA frameshift_variant&missense_variant 0.44 linezolid
rplC 801276 c.468G>C synonymous_variant 0.42 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.41 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 0.4 linezolid
rplC 801312 c.504G>C synonymous_variant 0.33 linezolid
rplC 801324 c.516T>C synonymous_variant 0.32 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303435 c.505_506delTCinsAG synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303441 c.511T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303444 p.Ser172Ala missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303455 c.525C>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303458 c.528G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303464 c.534A>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303506 c.576C>T synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>A synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303580 p.Thr217Ser missense_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303613 p.Leu228Gln missense_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>A synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303666 p.Thr246Ala missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303680 c.750G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303689 c.759T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304481 c.1551T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304490 c.1560C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>G synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304502 c.1572G>A synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304503 c.1573C>T synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304520 c.1590A>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304532 c.1602G>A synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304538 c.1608C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304544 p.Asp538Glu missense_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304547 c.1617C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304583 c.1653C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304604 c.1674C>T synonymous_variant 0.54 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304607 c.1677C>T synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304608 p.Thr560Val missense_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304649 c.1719C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304798 p.Ala623Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304845 p.Ala639Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305213 c.2283C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305219 c.2289T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>T synonymous_variant 0.39 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305237 c.2307A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305249 c.2319G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305259 c.2329T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305264 c.2334C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305267 c.2337C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305277 p.His783Asn missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305348 c.2418C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305360 c.2430G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
embR 1417019 p.Cys110Tyr missense_variant 0.88 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 0.85 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 0.92 ethambutol
atpE 1460816 c.-229T>C upstream_gene_variant 0.26 bedaquiline
atpE 1461056 c.12T>A synonymous_variant 0.26 bedaquiline
atpE 1461062 c.18T>G synonymous_variant 0.29 bedaquiline
atpE 1461086 c.42A>C synonymous_variant 0.5 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.47 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.5 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.54 bedaquiline
atpE 1461131 c.87T>C synonymous_variant 0.57 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.59 bedaquiline
atpE 1461137 c.93C>G synonymous_variant 0.57 bedaquiline
atpE 1461146 c.102G>C synonymous_variant 0.62 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.63 bedaquiline
atpE 1461158 c.114T>A synonymous_variant 0.63 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.63 bedaquiline Uncertain significance
atpE 1461164 c.120C>G synonymous_variant 0.65 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.63 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.65 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.67 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.61 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.52 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472305 n.460_466delTTCTCTCinsATTTTTCTG non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1473792 n.135C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473793 n.136G>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473802 n.145C>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474105 n.448_449delTAinsCGATG non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474107 n.451_453delCAA non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474288 n.631_644delCCTTTTCCTCTCCGinsTCCCCTT non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474306 n.649A>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474713 n.1056T>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475407 n.1750C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475428 n.1771G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475433 n.1776A>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1972_1973insC non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.85 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3033delC non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476693 n.3036delGinsCAA non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
inhA 1674399 c.198A>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674403 p.Glu68Gln missense_variant 0.3 ethionamide
isoniazid
inhA 1674416 p.Ala72Asp missense_variant 0.27 ethionamide
isoniazid
inhA 1674419 p.Ser73Thr missense_variant 0.26 ethionamide
isoniazid
inhA 1674421 c.220T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674428 p.Gly76Ala missense_variant 0.26 ethionamide
isoniazid
inhA 1674432 c.231G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674435 c.234G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674441 c.240G>A synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674443 p.Ala81Val missense_variant 0.31 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.36 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.51 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.5 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674537 c.336C>G synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.47 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.47 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.65 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.63 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.52 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.57 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674876 c.675C>T synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.41 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674892 p.Asn231Asp missense_variant 0.41 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674900 c.699G>A synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674904 c.703_705delGCGinsCC frameshift_variant&missense_variant 0.38 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674927 c.726G>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674933 c.732G>A synonymous_variant 0.44 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674942 c.741T>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674963 c.762G>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674966 c.765T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.42 ethionamide
isoniazid
inhA 1674970 p.Ile257Val missense_variant 0.43 ethionamide
isoniazid
rpsA 1833547 c.6G>A synonymous_variant 0.53 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.6 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.6 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.6 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.61 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.62 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.63 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
rpsA 1833664 c.123C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.69 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.7 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.69 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.65 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.65 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.67 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.67 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.63 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.64 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.63 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.62 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.6 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.63 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.62 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.63 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.6 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.61 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 0.63 pyrazinamide
rpsA 1834039 c.498C>T synonymous_variant 0.57 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.56 pyrazinamide
rpsA 1834094 c.553C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.43 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.4 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.43 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.59 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.56 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.69 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.7 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.71 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.72 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.75 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.74 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.74 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834525 c.984G>A synonymous_variant 0.73 pyrazinamide
rpsA 1834527 p.Arg329Gln missense_variant 0.72 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.72 pyrazinamide
rpsA 1834564 c.1023C>T synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
rpsA 1834573 c.1032G>C synonymous_variant 0.72 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.71 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.72 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.69 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.65 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.6 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.53 pyrazinamide Uncertain significance
rpsA 1834759 c.1218A>T synonymous_variant 0.49 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.5 pyrazinamide
rpsA 1834775 c.1234_1236delGCCinsAT frameshift_variant&missense_variant 0.43 pyrazinamide Uncertain significance
rpsA 1834780 c.1239A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.45 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.56 linezolid
tsnR 1853370 c.-236_-234delGCAinsAC upstream_gene_variant 0.52 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.57 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.57 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.56 linezolid
tsnR 1853401 c.-205A>G upstream_gene_variant 0.54 linezolid
tsnR 1853403 c.-203A>G upstream_gene_variant 0.59 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 0.52 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.53 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.54 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.54 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.5 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.43 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.43 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.4 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.39 linezolid
tsnR 1853480 c.-126G>C upstream_gene_variant 0.38 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.38 linezolid
tsnR 1853490 c.-116C>G upstream_gene_variant 0.39 linezolid
tsnR 1853495 c.-111G>A upstream_gene_variant 0.38 linezolid
tsnR 1853516 c.-90C>G upstream_gene_variant 0.37 linezolid
tsnR 1853523 c.-83_-82delCGinsAA upstream_gene_variant 0.34 linezolid
tsnR 1853528 c.-78G>C upstream_gene_variant 0.34 linezolid
tsnR 1853531 c.-75A>G upstream_gene_variant 0.34 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.34 linezolid
tsnR 1853543 c.-63C>T upstream_gene_variant 0.36 linezolid
tsnR 1853552 c.-54C>G upstream_gene_variant 0.33 linezolid
tsnR 1853561 c.-45G>C upstream_gene_variant 0.29 linezolid
tsnR 1853974 c.369C>T synonymous_variant 0.83 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 0.62 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168742 p.Gly624Asp missense_variant 0.84 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 0.9 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223553 c.-389C>A upstream_gene_variant 0.89 clofazimine Not assoc w R
bedaquiline Uncertain significance
kasA 2517917 c.-198G>C upstream_gene_variant 0.44 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.35 isoniazid
kasA 2517956 c.-159G>A upstream_gene_variant 0.34 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.26 isoniazid
kasA 2517983 c.-132T>C upstream_gene_variant 0.24 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.59 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.26 isoniazid
kasA 2518240 c.126C>A synonymous_variant 0.25 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.27 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.27 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.27 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.26 isoniazid
kasA 2518290 p.Lys59Arg missense_variant 0.24 isoniazid
kasA 2518300 c.186T>G synonymous_variant 0.26 isoniazid
kasA 2518309 c.195G>A synonymous_variant 0.28 isoniazid
kasA 2518312 c.198T>C synonymous_variant 0.28 isoniazid
kasA 2518322 p.Ser70Asp missense_variant 0.3 isoniazid
kasA 2518336 c.222A>G synonymous_variant 0.28 isoniazid
kasA 2518337 c.223_225delCTCinsTG frameshift_variant&missense_variant 0.28 isoniazid
kasA 2518343 p.Met77Leu missense_variant 0.28 isoniazid
kasA 2518348 c.234A>G synonymous_variant 0.28 isoniazid
kasA 2518470 p.Ala119Gly missense_variant 0.3 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.37 isoniazid
kasA 2518488 p.Ser125Thr missense_variant 0.39 isoniazid
kasA 2518492 c.378C>T synonymous_variant 0.42 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.59 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.62 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.66 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.67 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.68 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.67 isoniazid
kasA 2518579 c.465T>G synonymous_variant 0.68 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.69 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.69 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.7 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.73 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.71 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.72 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.68 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.73 isoniazid
kasA 2518681 c.567C>T synonymous_variant 0.72 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.73 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.75 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.74 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.73 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.73 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.74 isoniazid
kasA 2518727 c.613C>T synonymous_variant 0.76 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.77 isoniazid
kasA 2518739 p.Ala209Thr missense_variant 0.76 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.77 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.71 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.71 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.67 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.67 isoniazid
kasA 2518787 c.673_675delCGGinsGC frameshift_variant&missense_variant 0.67 isoniazid
kasA 2518795 c.681C>A synonymous_variant 0.66 isoniazid
kasA 2518816 c.702C>G synonymous_variant 0.66 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.61 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.59 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.53 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.53 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.5 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.5 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.43 isoniazid
kasA 2518882 c.768C>T synonymous_variant 0.43 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.45 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.38 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.27 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.86 isoniazid
ahpC 2726564 c.372C>G synonymous_variant 0.5 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.52 isoniazid
ahpC 2726582 c.390G>C synonymous_variant 0.54 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.52 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.52 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.55 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.58 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.62 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.61 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.52 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.47 isoniazid
ahpC 2726678 c.486G>A synonymous_variant 0.47 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.45 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.47 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.44 isoniazid
ahpC 2726705 c.513C>T synonymous_variant 0.36 isoniazid
Rv2477c 2782522 c.1521G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782570 c.1473C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782612 c.1431T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782615 c.1428G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782816 c.1227T>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782822 c.1221G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782828 c.1215T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782840 c.1203C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Ser missense_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782876 c.1167G>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782906 c.1137G>A synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782924 c.1119G>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782928 p.Thr372Glu missense_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>T synonymous_variant 0.73 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782981 c.1062G>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782987 c.1056C>G synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783014 p.Ser343Thr missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>A synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783134 c.909G>A synonymous_variant 0.29 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783192 p.Ser284Asn missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783218 c.825C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 p.Gln255Ala missense_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783407 c.636C>G synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783444 p.Gln200Ser missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783449 c.594C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783506 c.537C>T synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783509 c.534C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783523 c.520C>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783545 c.498C>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.65 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>A synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783646 p.Asp133Asn missense_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783728 c.315G>A synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783788 c.255T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783824 c.219G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783872 c.171G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 p.Lys56Thr missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.6 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783935 c.108C>G synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.67 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783956 p.Tyr29Leu missense_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783986 c.57G>C synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784017 p.Lys9Arg missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859708 c.711C>T synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859723 c.696T>C synonymous_variant 0.29 clofazimine Not assoc w R - Interim
bedaquiline
pepQ 2859735 c.684G>C synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859741 c.678C>G synonymous_variant 0.33 clofazimine
bedaquiline
pepQ 2859747 c.672C>G synonymous_variant 0.34 clofazimine
bedaquiline
pepQ 2859765 c.654G>C synonymous_variant 0.32 clofazimine
bedaquiline
pepQ 2859774 c.645C>T synonymous_variant 0.33 clofazimine
bedaquiline
pepQ 2859792 p.Asp209Glu missense_variant 0.31 clofazimine Uncertain significance
bedaquiline Uncertain significance
pepQ 2859813 c.606C>A synonymous_variant 0.27 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.19 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
Rv2680 2995816 c.-289C>T upstream_gene_variant 0.94 capreomycin
Rv2752c 3064887 c.1303_1305delAAAinsCG frameshift_variant&missense_variant 0.41 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064890 c.1302C>G synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064896 c.1296T>C synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064914 c.1278T>G synonymous_variant 0.49 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064932 c.1260T>C synonymous_variant 0.56 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064935 c.1257A>G synonymous_variant 0.56 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064941 c.1249_1251delCAAinsGG frameshift_variant&missense_variant 0.56 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064944 c.1248G>C synonymous_variant 0.56 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064947 c.1245A>C synonymous_variant 0.56 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064950 c.1242C>G synonymous_variant 0.56 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.57 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064969 p.Lys408Ala missense_variant 0.55 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.54 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>C synonymous_variant 0.47 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065004 c.1188G>A synonymous_variant 0.48 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1162_1164delGTGinsAC frameshift_variant&missense_variant 0.46 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065031 c.1161G>A synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065055 c.1137T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065580 c.612G>C synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065595 p.Leu199Phe missense_variant 0.46 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065607 c.585C>T synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065610 p.Thr194Lys missense_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065619 c.573C>G synonymous_variant 0.59 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065625 c.567G>C synonymous_variant 0.63 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065634 c.558G>C synonymous_variant 0.66 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065637 c.555A>G synonymous_variant 0.66 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065643 c.549C>G synonymous_variant 0.69 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065649 c.543T>G synonymous_variant 0.69 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065652 c.540C>G synonymous_variant 0.66 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065661 c.531A>G synonymous_variant 0.68 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065667 c.525A>G synonymous_variant 0.68 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065675 p.Phe173Leu missense_variant 0.68 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065697 c.493_495delATCinsGG frameshift_variant&missense_variant 0.67 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065703 c.489A>C synonymous_variant 0.68 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065715 c.475_477delTATinsCC frameshift_variant&missense_variant 0.65 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065727 c.465C>G synonymous_variant 0.66 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065732 c.460T>C synonymous_variant 0.62 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065742 p.Thr150Ile missense_variant 0.56 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065748 c.444T>C synonymous_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065757 c.435C>G synonymous_variant 0.58 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065898 c.294C>A synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065901 c.291A>C synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065907 c.285G>A synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 c.276T>C synonymous_variant 0.47 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065922 c.270T>C synonymous_variant 0.47 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065925 c.267G>C synonymous_variant 0.49 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065928 c.264G>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065946 p.Gly82Ala missense_variant 0.52 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065957 c.235T>C synonymous_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.6 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065982 c.210G>C synonymous_variant 0.6 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065988 p.Glu68Thr missense_variant 0.6 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065994 c.198T>C synonymous_variant 0.61 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065997 c.195C>G synonymous_variant 0.58 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066000 p.Met64Ile missense_variant 0.58 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066018 c.174T>C synonymous_variant 0.59 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 0.62 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>G synonymous_variant 0.59 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066045 c.147T>C synonymous_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 c.142T>C synonymous_variant 0.48 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066081 c.111G>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066084 c.108C>T synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066096 c.96G>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067337 c.609C>T synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067349 c.597G>T synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067379 c.567C>T synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.72 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067436 c.510C>T synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGG frameshift_variant&missense_variant 0.61 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.61 para-aminosalicylic_acid
thyX 3067469 c.477C>T synonymous_variant 0.61 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067496 c.450G>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067500 p.Lys149Arg missense_variant 0.53 para-aminosalicylic_acid
thyX 3067511 c.435G>A synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.43 para-aminosalicylic_acid
thyX 3067823 c.123G>A synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067848 p.Pro33His missense_variant 0.21 para-aminosalicylic_acid
thyX 3067850 c.96A>T synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073874 p.Ile200Val missense_variant 0.34 para-aminosalicylic_acid
thyA 3073881 c.591C>A synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3073887 p.Ser195Asp missense_variant 0.33 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073993 c.478_479delAGinsTC synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074004 p.Asp156Gly missense_variant 0.38 para-aminosalicylic_acid
thyA 3074027 p.Phe149Leu missense_variant 0.42 para-aminosalicylic_acid
thyA 3074028 c.444G>A synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074040 c.430_432delCCGinsGA frameshift_variant&missense_variant 0.39 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.41 para-aminosalicylic_acid
thyA 3074055 p.Glu139Asp missense_variant 0.42 para-aminosalicylic_acid
thyA 3074058 c.412_414delATCinsCG frameshift_variant&missense_variant 0.43 para-aminosalicylic_acid
thyA 3074070 c.402C>T synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074094 c.378G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074097 c.375C>A synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074103 c.369C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.3 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 0.86 ethionamide Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 0.89 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624637 p.His92Asn missense_variant 0.5 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 0.54 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.57 bedaquiline
rifampicin
lpqB 3624676 p.Asn79Asp missense_variant 0.57 bedaquiline
rifampicin
lpqB 3624677 c.234C>G synonymous_variant 0.57 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.57 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.59 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>G synonymous_variant 0.6 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.59 bedaquiline
rifampicin
lpqB 3624710 p.Leu67Arg missense_variant 0.6 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.59 bedaquiline
rifampicin
lpqB 3624737 c.174C>G synonymous_variant 0.55 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.57 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.49 bedaquiline
rifampicin
lpqB 3624776 c.135T>G synonymous_variant 0.46 bedaquiline
rifampicin
lpqB 3625060 c.-150G>T upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625069 c.-159T>G upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625075 c.-165G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3625090 c.1524C>T synonymous_variant 0.5 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625095 p.Glu507Lys missense_variant 0.46 bedaquiline
rifampicin
lpqB 3625111 c.-201G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.58 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.56 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625141 c.-231T>C upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625150 c.-240C>T upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625162 c.-252T>A upstream_gene_variant 0.58 bedaquiline
rifampicin
lpqB 3625177 c.-267C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625528 c.-618G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.49 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625585 c.-675G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625591 c.-681C>T upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3625599 p.Met339Leu missense_variant 0.6 bedaquiline
rifampicin Uncertain significance
lpqB 3625612 c.-702G>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ser missense_variant 0.58 bedaquiline
rifampicin
mtrB 3625627 p.Asp329Glu missense_variant 0.59 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3625636 p.Ala326Glu missense_variant 0.61 bedaquiline
rifampicin
mtrB 3625645 c.969C>T synonymous_variant 0.61 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.62 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.66 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625687 c.-777G>C upstream_gene_variant 0.67 bedaquiline
rifampicin
lpqB 3625690 c.-780T>G upstream_gene_variant 0.68 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.66 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.65 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.65 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.65 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.63 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625819 c.795G>A synonymous_variant 0.61 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625882 c.-972G>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3625899 p.Val239Leu missense_variant 0.35 bedaquiline
rifampicin
lpqB 3625909 c.-999T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626467 c.147G>A synonymous_variant 0.65 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3626684 c.-71G>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrA 3626729 c.619_621delAAGinsCA frameshift_variant&missense_variant 0.51 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626735 c.-122C>A upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626738 c.-125G>A upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3626750 c.-137T>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626776 c.-163A>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626804 c.-191A>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626816 c.-203G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrA 3626822 p.Asp176Glu missense_variant 0.52 bedaquiline
rifampicin
mtrB 3626843 c.-230G>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrA 3626907 p.Asn148Gly missense_variant 0.62 bedaquiline
rifampicin
mtrA 3626912 p.Thr146Ser missense_variant 0.62 bedaquiline
rifampicin
mtrB 3626924 c.-311G>A upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.64 bedaquiline
rifampicin
mtrA 3626942 c.406_408delGTAinsAC frameshift_variant&missense_variant 0.64 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3626999 c.-386G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627068 c.282T>G synonymous_variant 0.68 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.65 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3627131 p.Ala73Lys missense_variant 0.56 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.58 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrA 3627213 p.Arg46His missense_variant 0.69 bedaquiline
rifampicin
mtrB 3627224 c.-611G>C upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrA 3627247 p.Ile35Val missense_variant 0.65 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3627272 c.-659G>C upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3627323 c.25_27delTTGinsCC frameshift_variant&missense_variant 0.39 bedaquiline
rifampicin
fbiB 3641923 p.Ala130Glu missense_variant 0.73 clofazimine
pretomanid
delamanid
rpoA 3877514 p.Thr332Ala missense_variant 0.33 rifampicin Uncertain significance
rpoA 3877534 p.Val325Ala missense_variant 0.38 rifampicin
rpoA 3877548 c.960C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877553 p.Glu319Gln missense_variant 0.34 rifampicin
rpoA 3877554 c.954G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877557 c.951C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.38 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.49 rifampicin
rpoA 3877611 c.895_897delATCinsGG frameshift_variant&missense_variant 0.52 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.54 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.56 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.57 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 0.59 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.6 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.79 rifampicin
rpoA 3877800 c.708G>C synonymous_variant 0.79 rifampicin
rpoA 3877815 c.693C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.83 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.81 rifampicin
rpoA 3877869 c.639G>A synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.8 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.79 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.76 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.67 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.51 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.47 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.36 rifampicin
rpoA 3878124 c.384G>T synonymous_variant 0.29 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.32 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.33 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.56 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.7 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3878166 c.342C>G synonymous_variant 0.72 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.68 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3878244 p.Glu88Asp missense_variant 0.71 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.7 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.7 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.65 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.66 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.62 rifampicin
rpoA 3878304 c.204G>C synonymous_variant 0.57 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.58 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.52 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.49 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.5 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.49 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.41 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.42 rifampicin
rpoA 3878394 c.114G>T synonymous_variant 0.43 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.35 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.31 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.31 rifampicin
rpoA 3878672 c.-165A>T upstream_gene_variant 0.5 rifampicin
rpoA 3878694 c.-187A>G upstream_gene_variant 0.68 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.66 rifampicin
rpoA 3878704 c.-197C>T upstream_gene_variant 0.65 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.73 rifampicin Uncertain significance
rpoA 3878725 c.-218A>G upstream_gene_variant 0.72 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.75 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.78 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.78 rifampicin Uncertain significance
rpoA 3878758 c.-251G>C upstream_gene_variant 0.74 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.77 rifampicin
rpoA 3878775 c.-268A>G upstream_gene_variant 0.8 rifampicin Uncertain significance
rpoA 3878782 c.-275G>C upstream_gene_variant 0.78 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.79 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.79 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.79 rifampicin
rpoA 3878808 c.-301G>T upstream_gene_variant 0.81 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.81 rifampicin
rpoA 3878830 c.-325_-323delCTGinsAC upstream_gene_variant 0.83 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.81 rifampicin
rpoA 3878844 c.-337C>A upstream_gene_variant 0.83 rifampicin
rpoA 3878845 c.-338G>C upstream_gene_variant 0.83 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.84 rifampicin
rpoA 3878873 c.-366G>A upstream_gene_variant 0.73 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.73 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.68 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.69 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.69 rifampicin
rpoA 3878899 c.-392C>T upstream_gene_variant 0.69 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.73 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.7 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.7 rifampicin
rpoA 3878935 c.-428C>T upstream_gene_variant 0.65 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.65 rifampicin
rpoA 3878947 c.-440G>T upstream_gene_variant 0.61 rifampicin
rpoA 3878950 c.-443C>T upstream_gene_variant 0.58 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.57 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.52 rifampicin
rpoA 3878965 c.-458C>G upstream_gene_variant 0.35 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3879073 c.-566A>G upstream_gene_variant 0.48 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.47 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.46 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879097 c.-590C>T upstream_gene_variant 0.47 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.55 rifampicin
rpoA 3879125 c.-618T>G upstream_gene_variant 0.54 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.54 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.54 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.56 rifampicin
rpoA 3879178 c.-671T>G upstream_gene_variant 0.5 rifampicin
rpoA 3879190 c.-683C>A upstream_gene_variant 0.46 rifampicin
rpoA 3879199 c.-692C>A upstream_gene_variant 0.41 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.4 rifampicin
ddn 3986624 c.-220G>C upstream_gene_variant 0.63 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.58 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.51 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.39 delamanid
pretomanid
ddn 3986665 c.-179_-178delGCinsCG upstream_gene_variant 0.41 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.4 delamanid
pretomanid
ddn 3986687 c.-157C>T upstream_gene_variant 0.35 delamanid
pretomanid
ddn 3986690 c.-154C>G upstream_gene_variant 0.31 delamanid
pretomanid
ddn 3986699 c.-145C>G upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3987162 p.Leu107Val missense_variant 0.82 delamanid
pretomanid
clpC1 4038293 c.2412G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038305 c.2400C>G synonymous_variant 0.44 pyrazinamide
clpC1 4038310 p.Val799Leu missense_variant 0.42 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038325 p.Val794Leu missense_variant 0.38 pyrazinamide
clpC1 4038335 c.2370C>G synonymous_variant 0.39 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.45 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.45 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.47 pyrazinamide
clpC1 4038395 c.2310C>G synonymous_variant 0.47 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.62 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.65 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.65 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.65 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.71 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.72 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.72 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.72 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.72 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.72 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.73 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4038692 c.2013C>T synonymous_variant 0.75 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.75 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.74 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.8 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4038770 c.1935C>T synonymous_variant 0.86 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.86 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.81 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4038794 c.1909_1911delAGCinsTCG synonymous_variant 0.78 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.73 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.77 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.77 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.77 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.76 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.76 pyrazinamide
clpC1 4038923 c.1782A>C synonymous_variant 0.78 pyrazinamide
clpC1 4038935 c.1770C>T synonymous_variant 0.8 pyrazinamide
clpC1 4038941 c.1764G>T synonymous_variant 0.77 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.77 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.76 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.76 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.74 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4039067 c.1638G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.72 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.75 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.75 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.73 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.74 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.75 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.77 pyrazinamide
clpC1 4039141 p.Glu522Lys missense_variant 0.76 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.76 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.82 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.8 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039205 c.1500C>A synonymous_variant 0.8 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4039265 c.1440C>T synonymous_variant 0.79 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.82 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039295 c.1408_1410delTCAinsGC frameshift_variant&missense_variant 0.77 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.77 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.79 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.79 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.77 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.78 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.73 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.75 pyrazinamide
clpC1 4039355 c.1350G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.78 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.72 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.75 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.75 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.76 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.77 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.75 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.74 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4039487 c.1218G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.77 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.81 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.81 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Ser missense_variant 0.8 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4039581 p.Thr375Ser missense_variant 0.79 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.68 pyrazinamide
clpC1 4039685 c.1020C>A synonymous_variant 0.61 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.6 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.61 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.66 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.66 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.68 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.66 pyrazinamide
clpC1 4039886 c.819C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039898 c.805_807delCTCinsTG frameshift_variant&synonymous_variant 0.63 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.65 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.65 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.73 pyrazinamide
clpC1 4040001 p.His235Ala missense_variant 0.75 pyrazinamide
clpC1 4040020 c.685C>T synonymous_variant 0.71 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.71 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.74 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.75 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.73 pyrazinamide
clpC1 4040065 c.640C>T synonymous_variant 0.72 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.73 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040135 c.570C>G synonymous_variant 0.7 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.69 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.69 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040165 c.540G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.72 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.73 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.71 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.73 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.75 pyrazinamide
clpC1 4040225 c.480A>G synonymous_variant 0.75 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.72 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.72 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.67 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.61 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.43 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040306 c.399G>A synonymous_variant 0.43 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.4 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4040419 c.286C>T synonymous_variant 0.63 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.69 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.68 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.66 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.65 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.64 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.6 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.64 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.59 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.6 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.56 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.55 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.51 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.49 pyrazinamide
clpC1 4040597 c.108C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.45 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.45 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.45 pyrazinamide
clpC1 4040612 c.93G>A synonymous_variant 0.47 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.49 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.42 pyrazinamide
clpC1 4040645 c.60C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040660 c.45G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040663 c.42C>G synonymous_variant 0.34 pyrazinamide
clpC1 4040669 c.36C>T synonymous_variant 0.35 pyrazinamide
clpC1 4040681 c.24T>G synonymous_variant 0.33 pyrazinamide
panD 4044977 c.-696T>C upstream_gene_variant 0.23 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.24 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.24 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 0.82 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138556 c.1200G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.51 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Thr missense_variant 0.43 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138714 p.Ala348Ser missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138719 p.Ser346Val missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138726 p.Ala344Thr missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138748 c.1008G>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240632 p.Met257Thr missense_variant 0.56 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.54 ethambutol
embC 4240654 c.792C>G synonymous_variant 0.54 ethambutol Not assoc w R - Interim
embC 4240657 c.795G>C synonymous_variant 0.54 ethambutol
embC 4240671 p.ThrGlyGly270MetSerPro missense_variant 0.58 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.29 ethambutol Not assoc w R
embC 4240687 c.825C>G synonymous_variant 0.55 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.53 ethambutol
embC 4240695 p.Ile278Thr missense_variant 0.53 ethambutol
embC 4240697 p.Ala279Leu missense_variant 0.53 ethambutol
embC 4240702 c.840G>A synonymous_variant 0.53 ethambutol
embC 4240717 c.855T>C synonymous_variant 0.61 ethambutol
embC 4240736 c.874_875delTCinsAG synonymous_variant 0.64 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.53 ethambutol
embC 4240768 c.906G>C synonymous_variant 0.48 ethambutol
embC 4240769 c.907_909delGTGinsAC frameshift_variant&missense_variant 0.48 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.5 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.47 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.47 ethambutol
embC 4240800 p.Tyr313Phe missense_variant 0.54 ethambutol
embC 4240804 c.942C>T synonymous_variant 0.54 ethambutol Not assoc w R - Interim
embC 4240819 c.957A>C synonymous_variant 0.53 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.52 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.55 ethambutol
embC 4240859 p.Leu333Val missense_variant 0.46 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.41 ethambutol
embC 4240869 c.1007_1008insCG frameshift_variant 0.35 ethambutol
embC 4240873 c.1012_1013delAG frameshift_variant 0.35 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.35 ethambutol
embC 4240880 p.Ala340Ser missense_variant 0.35 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.35 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.33 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.33 ethambutol
embC 4240912 c.1050G>C synonymous_variant 0.32 ethambutol
embC 4240918 c.1056G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4240921 c.1059C>G synonymous_variant 0.33 ethambutol
embC 4240922 p.Thr354Ala missense_variant 0.33 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.74 ethambutol Not assoc w R
embC 4241071 c.1209C>G synonymous_variant 0.24 ethambutol
embC 4241084 p.Leu408Ala missense_variant 0.27 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4241134 c.1272G>A synonymous_variant 0.35 ethambutol
embC 4241135 p.Val425Leu missense_variant 0.35 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.33 ethambutol Uncertain significance
embC 4241146 c.1284C>T synonymous_variant 0.33 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.33 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.33 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.38 ethambutol
embC 4241185 c.1323G>C synonymous_variant 0.31 ethambutol
embC 4241188 c.1326C>G synonymous_variant 0.3 ethambutol
embC 4241197 c.1335G>C synonymous_variant 0.31 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.29 ethambutol
embC 4241530 c.1668C>G synonymous_variant 0.28 ethambutol
embC 4241536 c.1674A>C synonymous_variant 0.3 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>G synonymous_variant 0.3 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.28 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.28 ethambutol
embC 4241560 c.1698C>G synonymous_variant 0.3 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.28 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.3 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.28 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.28 ethambutol
embC 4241591 p.Leu577Ile missense_variant 0.31 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.32 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.32 ethambutol
embC 4241623 c.1761C>G synonymous_variant 0.33 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.35 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embC 4241656 c.1794G>T synonymous_variant 0.31 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 0.81 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 0.88 ethambutol Not assoc w R
embB 4248157 c.1644A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embB 4248173 p.Val554Met missense_variant 0.43 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.47 ethambutol
embB 4248202 c.1689T>C synonymous_variant 0.43 ethambutol
embB 4248203 p.Pro564Ala missense_variant 0.43 ethambutol
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.43 ethambutol
embB 4248215 p.Arg568Ser missense_variant 0.48 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.49 ethambutol
embB 4248225 p.Ala571Val missense_variant 0.47 ethambutol Uncertain significance
embB 4248248 c.1735_1737delTTCinsCG frameshift_variant&missense_variant 0.5 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.5 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.51 ethambutol
embB 4248264 p.Phe584Ser missense_variant 0.51 ethambutol
embB 4248275 c.1762_1764delACGinsGC frameshift_variant&missense_variant 0.52 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.32 ethambutol
embB 4248318 c.1806_1807delAG frameshift_variant 0.29 ethambutol
embB 4248323 p.Ala604Pro missense_variant 0.28 ethambutol
embB 4248325 c.1813_1814insAG frameshift_variant 0.27 ethambutol
embB 4248338 c.1825C>T synonymous_variant 0.35 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.36 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.35 ethambutol
embB 4248382 c.1869C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
ubiA 4269387 p.Glu149Asp missense_variant 0.65 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.89 ethambutol Not assoc w R
ethA 4326148 c.1326G>T synonymous_variant 0.94 ethionamide Not assoc w R - Interim
ethA 4326439 p.Asn345Lys missense_variant 0.88 ethionamide Uncertain significance
whiB6 4338203 p.Arg107Cys missense_variant 0.75 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.81 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 0.9 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 0.68 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.38 streptomycin Not assoc w R