TB-Profiler result

Run: ERR4810624
Summary

Run ID: ERR4810624

Sample name:

Date: 2024-04-16T12:31:19.374704

Number of reads: 2209317

Percentage reads mapped: 29.3

Median coverage: 45.0

Strain: lineage2.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Asp311Gly Mutation from literature
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.202_204delCTGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.838_840delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2542_2544delACTinsTC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 490984 c.202_204delCTGinsAC frameshift_variant&missense_variant 0.5 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.62 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.35 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491620 c.838_840delATCinsGG frameshift_variant&missense_variant 0.29 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.72 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpsL 781687 p.Lys43Arg missense_variant 0.43 streptomycin Assoc w R
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.44 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305472 c.2542_2544delACTinsTC frameshift_variant&missense_variant 0.28 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247445 p.Asp311Gly missense_variant 0.35 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 690 c.690G>C synonymous_variant 0.29 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 702 c.702C>G synonymous_variant 0.46 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.48 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.55 isoniazid
dnaA 723 c.723A>G synonymous_variant 0.57 isoniazid
dnaA 729 c.729C>G synonymous_variant 0.6 isoniazid Not assoc w R - Interim
dnaA 741 c.741T>C synonymous_variant 0.63 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.64 isoniazid
dnaA 765 c.765G>A synonymous_variant 0.66 isoniazid
dnaA 767 p.Val256Ala missense_variant 0.66 isoniazid
dnaA 769 c.769_771delGCAinsTG frameshift_variant&stop_gained 0.66 isoniazid Uncertain significance
dnaA 792 c.792C>T synonymous_variant 0.69 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.68 isoniazid Uncertain significance
dnaA 805 c.805T>C synonymous_variant 0.68 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.7 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.72 isoniazid Not assoc w R - Interim
dnaA 834 c.834C>T synonymous_variant 0.71 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.72 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.73 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.73 isoniazid
dnaA 873 c.873C>T synonymous_variant 0.71 isoniazid Not assoc w R - Interim
dnaA 877 c.877T>C synonymous_variant 0.7 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.69 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.68 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.65 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.66 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.65 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.62 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.61 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.62 isoniazid
dnaA 952 c.952C>T synonymous_variant 0.58 isoniazid
dnaA 955 c.955_957delAGAinsCG frameshift_variant&synonymous_variant 0.58 isoniazid Uncertain significance
dnaA 963 c.963C>G synonymous_variant 0.58 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.58 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.61 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.59 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>T synonymous_variant 0.54 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.51 isoniazid
dnaA 1002 c.1002G>A synonymous_variant 0.51 isoniazid
gyrB 6178 c.939C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6202 c.963C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6203 p.Ser322Ala missense_variant 0.35 levofloxacin
moxifloxacin
gyrB 6211 c.972G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAC frameshift_variant&missense_variant 0.34 levofloxacin Uncertain significance
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6228 p.Lys330Arg missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6307 c.-995T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6310 c.-992G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 6334 c.-968G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6352 c.1113C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6361 c.-941G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6362 c.1123_1125delTTGinsCC frameshift_variant&missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6398 p.Val387Ile missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6417 p.Thr393Ser missense_variant 0.36 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6460 c.-842G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6472 c.-830G>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6478 c.-824G>T upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 6487 c.1248C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6490 c.-812T>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6511 c.-791A>T upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 6514 c.1275G>A synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6523 c.-779G>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrB 6541 c.1302C>T synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6542 p.Ile435Leu missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6550 c.1311A>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6551 c.1312T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6571 c.-731T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6577 c.-725T>G upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 6583 c.-719G>C upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrB 6590 p.Arg451Ser missense_variant 0.68 levofloxacin
moxifloxacin
gyrA 6604 c.-698G>C upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>A upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrB 6664 c.1425C>T synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>T synonymous_variant 0.75 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6724 c.-578G>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6745 c.-557T>A upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.66 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 6803 c.-499C>T upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6850 c.-452C>T upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6860 p.Ser541Ala missense_variant 0.54 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6896 p.Arg553Lys missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6924 p.Phe562Tyr missense_variant 0.26 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7436 c.135C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7493 c.192C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7514 c.213C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7520 c.219G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7565 c.264C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7580 c.279C>T synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7596 c.295_297delATGinsCA frameshift_variant&missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7628 c.327G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7658 c.357A>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7664 c.363T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 7691 c.390C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7697 c.396C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 7703 c.402G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7709 c.408G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 7748 c.447A>T synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7758 p.Ile153Val missense_variant 0.69 levofloxacin Uncertain significance
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 7821 c.520C>T synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7868 c.567C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8199 p.Ser300Ala missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8207 c.906T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8231 c.930C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 8246 c.945C>T synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.68 levofloxacin
moxifloxacin
gyrA 8252 c.951G>A synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.65 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8300 c.999G>A synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.7 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.72 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 p.Glu429Asp missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8607 c.1306C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8663 c.1362C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8825 c.1524G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8990 c.1689C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9060 c.1759_1761delGCCinsAG frameshift_variant&missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 9142 c.1842_1847delTCGCGG disruptive_inframe_deletion 0.36 levofloxacin
moxifloxacin
gyrA 9150 c.1849_1851delTACinsAG frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 9155 c.1854_1855insTACGAA conservative_inframe_insertion 0.34 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9164 c.1863G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9174 c.1873C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9200 c.1899A>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9206 c.1905C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9208 p.Lys636Arg missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 9212 c.1911G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9218 p.Asp639Glu missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.54 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9267 p.Asn656Gly missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 9276 c.1975C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9281 c.1980C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9287 c.1986G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>T synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9332 c.2031C>T synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9419 c.2118T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9421 p.Ile707Thr missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 9430 p.Arg710Gln missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9602 c.2301T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9608 c.2307C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9616 p.Ser772Thr missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9626 c.2325T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9630 p.Val777Ile missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9638 c.2337C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9641 c.2340C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9650 c.2349G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9656 c.2355C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9659 c.2358C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9683 c.2382G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9686 c.2385A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9692 c.2391G>A synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9701 c.2400T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9704 c.2403T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9716 c.2415T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9738 c.2437_2439delTTGinsGT frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
fgd1 490902 c.120T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 490956 p.Met58Ile missense_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490968 c.186C>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 490980 p.Asn66Lys missense_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490983 c.201G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490987 p.Leu69Val missense_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491004 c.222G>A synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491005 c.223C>T synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491010 c.228C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491016 c.234C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491031 c.249C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491037 c.255C>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491070 c.288G>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491076 c.294G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491133 c.351A>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 491136 c.354C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 491153 p.Glu124Ala missense_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491172 c.390C>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491176 c.394C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491487 c.705C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491500 p.Glu240Lys missense_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491577 c.795G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491605 c.823C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575683 c.336G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575686 c.339G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575689 c.342G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575692 c.345G>A synonymous_variant 0.24 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.23 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575707 p.Leu120Phe missense_variant 0.26 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.4 ethionamide
isoniazid
mshA 575728 c.381C>T synonymous_variant 0.53 ethionamide
isoniazid
mshA 575731 c.384G>A synonymous_variant 0.51 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.49 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.52 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.58 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>G synonymous_variant 0.62 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.69 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.69 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.69 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.68 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.68 ethionamide
isoniazid
mshA 575788 c.441C>T synonymous_variant 0.7 ethionamide
isoniazid
mshA 575816 c.469C>T synonymous_variant 0.74 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.72 ethionamide
isoniazid
mshA 575851 c.504C>G synonymous_variant 0.73 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.7 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.67 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.66 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.6 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.6 ethionamide
isoniazid
mshA 575920 c.573C>T synonymous_variant 0.58 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575925 p.Gly193Ala missense_variant 0.58 ethionamide
isoniazid
mshA 575932 c.585G>A synonymous_variant 0.58 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.44 ethionamide
isoniazid
mshA 575945 p.Thr200Ala missense_variant 0.43 ethionamide
isoniazid
mshA 575953 c.606G>T synonymous_variant 0.43 ethionamide
isoniazid
mshA 575956 c.609G>A synonymous_variant 0.42 ethionamide
isoniazid
mshA 575965 c.618C>G synonymous_variant 0.38 ethionamide
isoniazid Not assoc w R - Interim
mshA 575968 c.621C>T synonymous_variant 0.34 ethionamide
isoniazid
ccsA 620238 c.348G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620247 p.Leu119Phe missense_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620264 p.Gly125Ala missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620271 c.381C>G synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620296 c.406_408delCCGinsGC frameshift_variant&missense_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620311 p.Leu141Val missense_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620319 c.429C>G synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620337 c.447C>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620404 c.514C>T synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620409 c.519C>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.48 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620439 c.549T>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620454 c.564C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620463 c.573C>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620547 c.657C>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620553 c.663T>C synonymous_variant 0.31 capreomycin Not assoc w R
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620559 c.669A>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620562 c.672C>G synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620569 c.679_681delGGAinsCG frameshift_variant&missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620583 c.693G>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620586 c.696C>A synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620589 c.699G>C synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>G synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 0.54 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>C synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620709 c.819G>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620715 c.825C>T synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620736 c.846G>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>A synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620754 c.864G>C synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.53 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620791 c.901_903delGTGinsAC frameshift_variant&missense_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620808 c.918T>C synonymous_variant 0.3 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657596 c.-126G>C upstream_gene_variant 0.27 ethionamide
Rv0565c 657620 c.-150C>T upstream_gene_variant 0.27 ethionamide
Rv0565c 657635 c.-167_-165delAGCinsTCG upstream_gene_variant 0.27 ethionamide
Rv0565c 657638 c.-170_-168delACCinsTG upstream_gene_variant 0.26 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.28 ethionamide
Rv0565c 657647 c.-177C>A upstream_gene_variant 0.31 ethionamide
Rv0565c 657650 c.-180G>A upstream_gene_variant 0.3 ethionamide
Rv0565c 657670 c.-200A>G upstream_gene_variant 0.39 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.4 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.39 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.43 ethionamide
Rv0565c 657725 c.-255G>C upstream_gene_variant 0.55 ethionamide
Rv0565c 657732 c.-263_-262delAGinsGA upstream_gene_variant 0.5 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.5 ethionamide
Rv0565c 657737 c.-267C>T upstream_gene_variant 0.5 ethionamide
hadA 731807 c.-123C>T upstream_gene_variant 0.21 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.23 rifampicin
nusG 734413 c.160_161delTCinsAG synonymous_variant 0.24 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.33 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.44 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.48 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.5 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.51 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.52 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.46 rifampicin
nusG 734566 c.313C>T synonymous_variant 0.42 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.43 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.36 rifampicin
nusG 734595 p.Asp114Glu missense_variant 0.31 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.3 rifampicin
nusG 734600 p.Thr116Asn missense_variant 0.3 rifampicin Uncertain significance
nusG 734607 p.Asp118Glu missense_variant 0.31 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.32 rifampicin
nusG 734615 p.Ala121Gly missense_variant 0.31 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.32 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.29 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.26 rifampicin
nusG 734640 c.387C>G synonymous_variant 0.25 rifampicin
nusG 734802 c.549C>G synonymous_variant 0.28 rifampicin
nusG 734807 p.Tyr185Phe missense_variant 0.34 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.34 rifampicin
nusG 734841 c.588G>C synonymous_variant 0.32 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.32 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.31 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.3 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.3 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.3 rifampicin
nusG 734862 c.609C>G synonymous_variant 0.3 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.3 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.32 rifampicin
nusG 734905 c.652C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734910 c.657C>G synonymous_variant 0.32 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.32 rifampicin
nusG 734925 c.672C>T synonymous_variant 0.28 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.28 rifampicin
nusG 734931 c.678A>G synonymous_variant 0.28 rifampicin
nusG 734940 c.687G>A synonymous_variant 0.27 rifampicin
rpoB 760130 c.324T>C synonymous_variant 0.27 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760140 c.334_336delCCCinsTG frameshift_variant&missense_variant 0.3 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760208 p.Ile134Met missense_variant 0.59 rifampicin
rpoB 760212 p.Asn136Ala missense_variant 0.59 rifampicin
rpoB 760215 c.409_411delAACinsGG frameshift_variant&missense_variant 0.58 rifampicin
rpoB 760219 p.Thr138Ser missense_variant 0.59 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.61 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.68 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.64 rifampicin
rpoB 760317 c.511_513delAGCinsTCG synonymous_variant 0.64 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.69 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.69 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.69 rifampicin
rpoB 760358 c.552C>G synonymous_variant 0.73 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.76 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.72 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.73 rifampicin Uncertain significance
rpoB 760424 c.618C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.74 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.75 rifampicin
rpoB 760499 c.693G>A synonymous_variant 0.76 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.73 rifampicin
rpoB 760514 c.708C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760532 c.726T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.73 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.71 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.74 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.71 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.62 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760910 c.1104C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.38 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.41 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.55 rifampicin
rpoB 760958 c.1152G>C synonymous_variant 0.58 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.56 rifampicin Uncertain significance
rpoB 760982 c.1176G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.63 rifampicin
rpoB 761003 c.1197C>G synonymous_variant 0.65 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.67 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.66 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>T synonymous_variant 0.76 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.77 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.82 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761346 p.Val514Arg missense_variant 0.7 rifampicin
rpoB 761355 c.1549_1551delGTGinsAC frameshift_variant&missense_variant 0.69 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.69 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.7 rifampicin
rpoB 761378 c.1572C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.52 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.35 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.61 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.64 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.67 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.7 rifampicin
rpoB 761654 c.1848G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.7 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.69 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.7 rifampicin
rpoB 761681 c.1875G>A synonymous_variant 0.7 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.69 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.73 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.64 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.73 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.73 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.74 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.69 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.72 rifampicin
rpoB 761789 c.1983G>C synonymous_variant 0.72 rifampicin
rpoB 761790 p.Arg662Tyr missense_variant 0.73 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.75 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.78 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.78 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.79 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.78 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.79 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.76 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.76 rifampicin
rpoB 761903 c.2097T>A synonymous_variant 0.75 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.73 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.73 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.73 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.74 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.73 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.74 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.74 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.75 rifampicin Uncertain significance
rpoB 761984 c.2178G>A synonymous_variant 0.76 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.75 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.75 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.76 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.76 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.73 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.75 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.75 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762221 c.2415G>A synonymous_variant 0.79 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>T synonymous_variant 0.78 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.77 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.75 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.73 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762287 c.2481C>T synonymous_variant 0.72 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.71 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.72 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.69 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.67 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.65 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.62 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.61 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.58 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.58 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.58 rifampicin
rpoC 762390 c.-980C>T upstream_gene_variant 0.58 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.56 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.55 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.57 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.7 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.62 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.61 rifampicin Uncertain significance
rpoC 762533 c.-837T>C upstream_gene_variant 0.56 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.55 rifampicin
rpoB 762537 c.2731_2733delTTGinsCC frameshift_variant&missense_variant 0.55 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.56 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.56 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.31 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.29 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 762786 p.Val994Lys missense_variant 0.24 rifampicin
rpoB 762798 p.Ala998Ser missense_variant 0.47 rifampicin
rpoB 762812 c.3006C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762820 p.Phe1005Tyr missense_variant 0.61 rifampicin
rpoC 762827 c.-543G>T upstream_gene_variant 0.63 rifampicin
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.62 rifampicin
rpoC 762851 c.-519C>T upstream_gene_variant 0.69 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.76 rifampicin
rpoB 762894 c.3088C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 762911 c.-459C>T upstream_gene_variant 0.81 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.83 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.83 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>A upstream_gene_variant 0.79 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.78 rifampicin
rpoB 763157 c.3351G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763193 c.-177C>T upstream_gene_variant 0.73 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.72 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.7 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.63 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.64 rifampicin
rpoC 763232 c.-138C>T upstream_gene_variant 0.63 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.64 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.65 rifampicin
rpoC 763259 c.-111G>C upstream_gene_variant 0.6 rifampicin
rpoC 763262 c.-108C>T upstream_gene_variant 0.58 rifampicin
rpoB 763265 c.3459G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763268 c.3462C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763289 c.-81C>G upstream_gene_variant 0.34 rifampicin
rpoC 763373 c.4_6delCTCinsTA frameshift_variant&missense_variant 0.33 rifampicin
rpoC 763396 c.27A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.42 rifampicin
rpoC 763405 c.36C>T synonymous_variant 0.42 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.43 rifampicin
rpoC 763417 c.48C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.43 rifampicin
rpoC 763433 c.64_66delCAAinsAT frameshift_variant&missense_variant 0.43 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.46 rifampicin
rpoC 763450 c.81G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763453 c.84C>A synonymous_variant 0.46 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.66 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.81 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>A synonymous_variant 0.82 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.8 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.78 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.76 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.76 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.75 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.77 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.73 rifampicin
rpoC 763781 p.Ser138Glu missense_variant 0.72 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.72 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.72 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.73 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.67 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.67 rifampicin
rpoC 763867 c.498C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763876 p.Glu169Asp missense_variant 0.63 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.64 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.7 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.71 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763930 c.561G>A synonymous_variant 0.74 rifampicin
rpoC 763940 p.Ala191Ser missense_variant 0.7 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.68 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.68 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.64 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.61 rifampicin
rpoC 763991 c.622_624delATCinsCT frameshift_variant&missense_variant 0.59 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.61 rifampicin
rpoC 764003 c.634_636delGCGinsTC frameshift_variant&missense_variant 0.63 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.64 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.68 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.67 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.68 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.67 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.61 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.61 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Gln missense_variant 0.61 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.68 rifampicin
rpoC 764143 c.774G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764147 c.778_780delTCGinsGC frameshift_variant&missense_variant 0.65 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.65 rifampicin
rpoC 764156 p.Lys263Arg missense_variant 0.65 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.61 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.54 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.48 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.47 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.47 rifampicin Uncertain significance
rpoC 764212 c.843C>T synonymous_variant 0.48 rifampicin
rpoC 764215 c.846A>G synonymous_variant 0.48 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.47 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.6 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.64 rifampicin
rpoC 764285 p.Gly306Ser missense_variant 0.63 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.68 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.69 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764368 c.999C>T synonymous_variant 0.73 rifampicin
rpoC 764371 c.1002G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.69 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.7 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.68 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.71 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764449 c.1080G>C synonymous_variant 0.75 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.75 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.74 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.74 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.75 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>G synonymous_variant 0.78 rifampicin
rpoC 764533 c.1164C>A synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.76 rifampicin
rpoC 764585 c.1216_1218delCTCinsTG frameshift_variant&missense_variant 0.75 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.77 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.81 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.78 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.78 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764839 c.1470C>G synonymous_variant 0.79 rifampicin
rpoC 764844 p.Ala492Gly missense_variant 0.78 rifampicin
rpoC 764851 c.1482C>T synonymous_variant 0.78 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.79 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.78 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.75 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.75 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.75 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.78 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.76 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>T synonymous_variant 0.68 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 0.67 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.67 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.64 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.65 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.61 rifampicin
rpoC 765118 c.1749C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765367 c.1998C>G synonymous_variant 0.4 rifampicin
rpoC 765397 c.2028G>T synonymous_variant 0.59 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.58 rifampicin
rpoC 765407 p.Gly680Gln missense_variant 0.57 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.59 rifampicin
rpoC 765451 c.2082C>G synonymous_variant 0.67 rifampicin
rpoC 765452 p.Ala695Arg missense_variant 0.69 rifampicin
rpoC 765458 p.Ile697Val missense_variant 0.69 rifampicin Uncertain significance
rpoC 765466 c.2097C>T synonymous_variant 0.7 rifampicin
rpoC 765478 c.2109T>G synonymous_variant 0.68 rifampicin
rpoC 765496 c.2127C>G synonymous_variant 0.66 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.5 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.5 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.5 rifampicin
rpoC 765770 p.Thr801Leu missense_variant 0.21 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.47 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.47 rifampicin
rpoC 765805 c.2436C>G synonymous_variant 0.49 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.5 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.68 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.7 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765925 c.2556C>T synonymous_variant 0.72 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.64 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.58 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.43 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.44 rifampicin
rpoC 766034 p.His889Thr missense_variant 0.34 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.33 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.35 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.39 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.45 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.51 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.5 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.44 rifampicin
rpoC 766423 c.3054T>C synonymous_variant 0.4 rifampicin
rpoC 766428 c.3060_3061insACCGGC conservative_inframe_insertion 0.36 rifampicin
rpoC 766433 p.Glu1022Ser missense_variant 0.34 rifampicin
rpoC 766438 c.3069C>T synonymous_variant 0.36 rifampicin
rpoC 766456 c.3087C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766459 c.3090G>C synonymous_variant 0.53 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.52 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.5 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.5 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.5 rifampicin
rpoC 766494 p.Gly1042Asp missense_variant 0.49 rifampicin Uncertain significance
rpoC 766517 c.3148_3150delACCinsTG frameshift_variant&missense_variant 0.44 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.44 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.44 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.44 rifampicin
rpoC 766537 c.3168G>A synonymous_variant 0.44 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.45 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.47 rifampicin
rpoC 766568 p.Val1067Ile missense_variant 0.5 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.52 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.52 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.49 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.32 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.38 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.46 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.55 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.63 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.66 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.67 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.67 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.69 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.68 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.68 rifampicin
rpoC 766798 c.3429C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.67 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.63 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.62 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.63 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.65 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.66 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.68 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.68 rifampicin
rpoC 766919 c.3550_3552delGCGinsTC frameshift_variant&missense_variant 0.68 rifampicin
rpoC 766931 c.3562_3564delGCAinsTC frameshift_variant&missense_variant 0.73 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>C synonymous_variant 0.73 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Met missense_variant 0.81 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767155 c.3786C>G synonymous_variant 0.77 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.76 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.54 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.52 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767288 c.3919C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775847 c.2634G>C synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.43 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 775886 c.2595A>C synonymous_variant 0.43 clofazimine
bedaquiline
mmpL5 775892 c.2589C>T synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775895 c.2584_2586delATCinsCA frameshift_variant&missense_variant 0.44 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775904 c.2577G>A synonymous_variant 0.39 clofazimine
bedaquiline
mmpL5 775910 c.2571G>C synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 775913 c.2568C>T synonymous_variant 0.48 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.6 clofazimine
bedaquiline
mmpL5 775921 c.2560C>T synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775924 c.2557C>T synonymous_variant 0.35 clofazimine Not assoc w R - Interim
bedaquiline
mmpL5 775925 c.2556G>T synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.66 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.68 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.29 clofazimine
bedaquiline
mmpL5 775970 c.2511G>C synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.67 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.68 clofazimine
bedaquiline
mmpL5 775982 p.Trp833Phe missense_variant 0.34 clofazimine
bedaquiline
mmpL5 775985 p.His832Gln missense_variant 0.36 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.54 clofazimine
bedaquiline
mmpL5 775997 c.2484T>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.24 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776009 c.2472A>G synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 776015 c.2464_2466delATCinsCA frameshift_variant&missense_variant 0.44 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776027 c.2454G>C synonymous_variant 0.49 clofazimine
bedaquiline
mmpL5 776036 c.2445G>C synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 776039 c.2442C>G synonymous_variant 0.57 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 0.98 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776207 c.2274G>C synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 776218 p.Ala755Thr missense_variant 0.36 clofazimine
bedaquiline
mmpL5 776219 c.2262C>G synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 776222 c.2259A>T synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 776230 c.2251T>C synonymous_variant 0.34 clofazimine
bedaquiline
mmpL5 776234 c.2247A>C synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 776261 p.Thr740Leu missense_variant 0.37 clofazimine
bedaquiline
mmpL5 776271 p.Lys737Ala missense_variant 0.37 clofazimine
bedaquiline
mmpL5 776274 p.Ala736Asp missense_variant 0.37 clofazimine
bedaquiline
mmpL5 776282 p.Ala733Asp missense_variant 0.36 clofazimine
bedaquiline
mmpL5 776291 p.Ala730Asp missense_variant 0.35 clofazimine
bedaquiline
mmpL5 776295 p.Gln729Ala missense_variant 0.35 clofazimine
bedaquiline
mmpL5 776300 c.2179_2181delATGinsCC frameshift_variant&missense_variant 0.35 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776309 c.2172C>T synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 776319 p.Ser721Asn missense_variant 0.33 clofazimine
bedaquiline
mmpL5 777085 p.Asn466Asp missense_variant 0.2 clofazimine
bedaquiline
mmpL5 777113 p.Met456Ile missense_variant 0.21 clofazimine
bedaquiline
mmpL5 777139 c.1342C>T synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777142 p.Val447Leu missense_variant 0.24 clofazimine
bedaquiline
mmpL5 777146 c.1335C>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.29 clofazimine
bedaquiline
mmpL5 777179 c.1302G>T synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777188 c.1293T>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777203 c.1278G>C synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 777212 c.1269C>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 777215 c.1266C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.21 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.38 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.4 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.41 streptomycin
rpsL 781679 c.120C>G synonymous_variant 0.51 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.58 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.58 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.57 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.58 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.56 streptomycin
rpsL 781735 p.Ser59Thr missense_variant 0.57 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.62 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.66 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.66 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.66 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.69 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.69 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.68 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.68 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.69 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.7 streptomycin
rpsL 781847 c.288G>A synonymous_variant 0.72 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.71 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.71 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.71 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.73 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.69 streptomycin
rpsL 781904 c.345C>T synonymous_variant 0.63 streptomycin Not assoc w R - Interim
rpsL 781907 c.348T>C synonymous_variant 0.63 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.62 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.66 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.52 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.63 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.67 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.69 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.69 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.68 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.68 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.69 linezolid
rplC 800585 c.-224T>C upstream_gene_variant 0.7 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.72 linezolid
rplC 800597 c.-212A>C upstream_gene_variant 0.73 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.74 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.77 linezolid
rplC 800615 c.-194G>A upstream_gene_variant 0.77 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.77 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.78 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.73 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.7 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.7 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.74 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.76 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.76 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.76 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.76 linezolid
rplC 800753 c.-56C>T upstream_gene_variant 0.75 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.72 linezolid
rplC 800774 c.-35C>T upstream_gene_variant 0.73 linezolid
rplC 800799 c.-10_-8delGGAinsC upstream_gene_variant 0.63 linezolid
rplC 800807 c.-2C>A upstream_gene_variant 0.62 linezolid
rplC 800814 c.6A>T synonymous_variant 0.58 linezolid
rplC 800815 c.7_9delCGAinsAG frameshift_variant&synonymous_variant 0.58 linezolid
rplC 800819 p.Lys4Arg missense_variant 0.56 linezolid
rplC 800829 c.21C>G synonymous_variant 0.6 linezolid
rplC 800832 c.24T>C synonymous_variant 0.61 linezolid
rplC 800844 c.36T>C synonymous_variant 0.65 linezolid
rplC 800856 c.48A>G synonymous_variant 0.68 linezolid
rplC 800865 c.57A>G synonymous_variant 0.67 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.66 linezolid
rplC 800874 c.66A>G synonymous_variant 0.68 linezolid
rplC 800877 c.69A>C synonymous_variant 0.69 linezolid
rplC 800880 c.72A>G synonymous_variant 0.69 linezolid
rplC 800889 c.81C>G synonymous_variant 0.68 linezolid
rplC 800892 c.84G>C synonymous_variant 0.66 linezolid
rplC 800904 c.96G>T synonymous_variant 0.67 linezolid
rplC 800913 c.105G>C synonymous_variant 0.63 linezolid
rplC 800916 c.108A>C synonymous_variant 0.63 linezolid
rplC 800919 c.111C>G synonymous_variant 0.62 linezolid
rplC 800931 c.123G>C synonymous_variant 0.6 linezolid
rplC 800932 p.Pro42Ala missense_variant 0.6 linezolid
rplC 800937 c.129A>G synonymous_variant 0.59 linezolid
rplC 800946 c.138T>C synonymous_variant 0.59 linezolid
rplC 800949 c.141T>C synonymous_variant 0.6 linezolid
rplC 800970 c.162T>C synonymous_variant 0.61 linezolid Not assoc w R - Interim
rplC 800981 p.Ser58Asn missense_variant 0.56 linezolid
rplC 800985 c.177A>G synonymous_variant 0.55 linezolid
rplC 800994 c.186C>G synonymous_variant 0.53 linezolid
rplC 801000 c.192G>A synonymous_variant 0.46 linezolid
rplC 801008 p.Thr67Lys missense_variant 0.39 linezolid
rplC 801019 p.Thr71Asp missense_variant 0.36 linezolid
rplC 801027 c.219C>G synonymous_variant 0.3 linezolid
rplC 801039 c.231A>C synonymous_variant 0.19 linezolid
rplC 801171 c.363A>G synonymous_variant 0.25 linezolid
rplC 801174 c.366T>C synonymous_variant 0.25 linezolid
rplC 801180 c.372C>G synonymous_variant 0.36 linezolid
rplC 801186 c.378C>G synonymous_variant 0.39 linezolid
rplC 801195 c.387G>C synonymous_variant 0.39 linezolid
rplC 801204 c.396C>T synonymous_variant 0.39 linezolid
rplC 801205 p.Arg133Ser missense_variant 0.38 linezolid
rplC 801222 c.414T>C synonymous_variant 0.38 linezolid
rplC 801228 c.420T>C synonymous_variant 0.38 linezolid
rplC 801237 c.429G>C synonymous_variant 0.43 linezolid
rplC 801249 c.441T>C synonymous_variant 0.44 linezolid
rplC 801252 c.444G>C synonymous_variant 0.46 linezolid
rplC 801255 c.447C>T synonymous_variant 0.47 linezolid
rplC 801267 c.459A>C synonymous_variant 0.51 linezolid
rplC 801270 c.462T>C synonymous_variant 0.49 linezolid
rplC 801273 c.465C>G synonymous_variant 0.51 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.53 linezolid
rplC 801309 c.501C>G synonymous_variant 0.57 linezolid
rplC 801312 c.504G>C synonymous_variant 0.58 linezolid
rplC 801327 c.519C>T synonymous_variant 0.48 linezolid
rplC 801330 c.522G>C synonymous_variant 0.42 linezolid
rplC 801333 c.525G>C synonymous_variant 0.38 linezolid
rplC 801337 p.Val177Thr missense_variant 0.39 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.37 linezolid
rplC 801348 c.540T>G synonymous_variant 0.38 linezolid
rplC 801357 c.549T>C synonymous_variant 0.42 linezolid
rplC 801372 c.564G>A synonymous_variant 0.39 linezolid
rplC 801382 c.574_576delCTGinsAT frameshift_variant&missense_variant 0.31 linezolid
Rv1129c 1254125 p.Tyr137Cys missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.98 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303431 c.501T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303441 c.511T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303444 p.Ser172Asp missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303452 c.522G>A synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303455 c.525C>G synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303473 c.543G>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303500 c.570C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1303578 c.648G>A synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303593 c.663G>A synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303645 p.Ala239Gln missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>T synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303662 c.732C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303665 c.735G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303666 p.Thr246Ala missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303689 c.759T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304007 c.1077G>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304037 c.1107G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304048 p.Ala373Gly missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304052 c.1122G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304065 p.Ala379Ser missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304095 p.Val389Met missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304099 p.Gln390Pro missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304106 c.1176G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304112 c.1182G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>A synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304616 c.1686C>T synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304619 c.1689G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304655 c.1725C>T synonymous_variant 0.69 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304658 c.1728C>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>A synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>A synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304709 c.1779C>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.78 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304763 c.1833C>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304766 c.1836C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304805 c.1875G>T synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>T synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304814 p.Met628Ile missense_variant 0.63 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1304826 c.1896G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.51 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305310 p.Arg794Trp missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305357 c.2427C>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305396 c.2466C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305399 c.2469A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305400 p.His824Phe missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305417 c.2487C>T synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305422 p.Ala831Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305430 p.Val834Thr missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305444 c.2514A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305458 p.Pro843Arg missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305465 c.2535C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305477 c.2547C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305485 p.Ala852Asp missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305488 p.Leu853Pro missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305492 c.2562T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
sigE 1364515 p.Leu35Phe missense_variant 1.0 pyrazinamide Uncertain significance
sigE 1364640 c.228G>T synonymous_variant 0.22 pyrazinamide
sigE 1364647 c.235_237delGCCinsTG frameshift_variant&missense_variant 0.24 pyrazinamide Uncertain significance
sigE 1364652 c.240C>G synonymous_variant 0.23 pyrazinamide
sigE 1364661 c.249C>G synonymous_variant 0.34 pyrazinamide
sigE 1364667 c.255T>C synonymous_variant 0.36 pyrazinamide
sigE 1364670 p.Glu86Asp missense_variant 0.39 pyrazinamide
sigE 1364676 c.264C>G synonymous_variant 0.41 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.47 pyrazinamide
sigE 1364703 c.291G>C synonymous_variant 0.56 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.57 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.57 pyrazinamide
sigE 1364733 c.321C>T synonymous_variant 0.6 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.63 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.63 pyrazinamide
sigE 1364751 c.339C>G synonymous_variant 0.63 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.62 pyrazinamide
sigE 1364767 c.355_357delAGGinsCC frameshift_variant&missense_variant 0.62 pyrazinamide Uncertain significance
sigE 1364781 c.369G>C synonymous_variant 0.65 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.63 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.64 pyrazinamide
sigE 1364793 c.381C>T synonymous_variant 0.63 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.68 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.7 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.69 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.68 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.67 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.65 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.61 pyrazinamide
sigE 1364860 c.448_450delCGCinsAG frameshift_variant&missense_variant 0.54 pyrazinamide Uncertain significance
sigE 1364865 c.453G>C synonymous_variant 0.55 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.55 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
sigE 1364883 c.471G>A synonymous_variant 0.57 pyrazinamide
sigE 1364886 c.474G>A synonymous_variant 0.59 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.57 pyrazinamide Uncertain significance
sigE 1364919 p.Asp169Glu missense_variant 0.68 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.7 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.62 pyrazinamide Uncertain significance
sigE 1364961 c.549A>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
sigE 1364964 c.552T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
sigE 1364980 c.568T>C synonymous_variant 0.63 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.63 pyrazinamide
sigE 1365003 c.591T>C synonymous_variant 0.6 pyrazinamide
sigE 1365009 c.597C>G synonymous_variant 0.59 pyrazinamide
sigE 1365012 c.600G>T synonymous_variant 0.59 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.59 pyrazinamide
sigE 1365027 c.615C>T synonymous_variant 0.59 pyrazinamide
sigE 1365036 c.624T>G synonymous_variant 0.54 pyrazinamide
sigE 1365037 c.625C>T synonymous_variant 0.54 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.54 pyrazinamide
sigE 1365063 c.651A>G synonymous_variant 0.32 pyrazinamide
sigE 1365066 c.654G>C synonymous_variant 0.3 pyrazinamide
sigE 1365068 p.Gly219Asp missense_variant 0.3 pyrazinamide Uncertain significance
sigE 1365072 c.660G>C synonymous_variant 0.31 pyrazinamide
sigE 1365081 c.669G>C synonymous_variant 0.28 pyrazinamide
sigE 1365084 c.672G>C synonymous_variant 0.28 pyrazinamide
sigE 1365087 c.675A>G synonymous_variant 0.28 pyrazinamide
sigE 1365090 c.678T>C synonymous_variant 0.28 pyrazinamide
sigE 1365096 c.684G>C synonymous_variant 0.28 pyrazinamide
sigE 1365099 c.687A>C synonymous_variant 0.29 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471508 n.-338T>C upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471511 n.-335C>G upstream_gene_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471514 n.-332A>C upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471521 n.-325T>C upstream_gene_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>T non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472279 n.434T>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472298 n.453_468delGTCCGGGTTCTCTCGGinsCGTA non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472325 n.480G>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472453 n.608G>A non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472459 n.614C>T non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473658 n.1T>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1473813 n.156C>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsGTA non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474179 n.523dupT non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474287 n.630_631delTCinsCTCA non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474293 n.637_647delCCTCTCCGGAG non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474418 n.761C>A non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474421 n.764_765delGCinsA non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474437 n.780_781delGAinsTTGGT non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474709 n.1053_1058delTGGTGT non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475017 n.1360G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475366 n.1709G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475404 n.1747A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475606 n.1949T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475616 n.1959A>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475618 n.1961C>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475622 n.1966_1967insCC non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475625 n.1969delT non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033_3034delCTinsTCC non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476740 n.3083G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476741 n.3084G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476743 n.3086A>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476744 n.3087G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476757 n.3100T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
fabG1 1673636 p.Asp66Ala missense_variant 0.24 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673652 c.-550C>G upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673658 c.-544G>C upstream_gene_variant 0.39 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.39 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1673673 c.-529C>T upstream_gene_variant 0.4 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.45 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673682 c.-520G>C upstream_gene_variant 0.44 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673697 c.-505G>C upstream_gene_variant 0.46 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.41 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.42 ethionamide
isoniazid
inhA 1673724 c.-478A>C upstream_gene_variant 0.43 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673733 p.Met98Ile missense_variant 0.46 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.48 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.48 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.51 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673787 c.-415G>A upstream_gene_variant 0.35 ethionamide
isoniazid Uncertain significance
inhA 1673799 c.-403T>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673890 p.Ala151Ser missense_variant 0.29 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.31 ethionamide
isoniazid
fabG1 1673905 c.466_468delTCCinsGT frameshift_variant&missense_variant 0.31 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.31 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.32 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.31 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.31 ethionamide
isoniazid
inhA 1673946 c.-256C>T upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1673967 c.-235G>C upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1673973 c.-229G>C upstream_gene_variant 0.32 ethionamide
isoniazid Uncertain significance
inhA 1673976 c.-226T>C upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673988 c.-214G>C upstream_gene_variant 0.37 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.28 ethionamide
isoniazid
inhA 1674015 c.-187C>T upstream_gene_variant 0.19 ethionamide
isoniazid Uncertain significance
inhA 1674450 c.249G>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674452 p.Ala84Asp missense_variant 0.24 ethionamide
isoniazid
inhA 1674462 c.261G>A synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674501 c.300G>A synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674502 c.301_303delACCinsTG frameshift_variant&missense_variant 0.52 ethionamide
isoniazid
inhA 1674525 c.324C>T synonymous_variant 0.61 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674542 p.Ala114Glu missense_variant 0.65 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.67 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.68 ethionamide
isoniazid
inhA 1674620 p.Pro140Arg missense_variant 0.65 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674628 c.427_428delTCinsAG synonymous_variant 0.64 ethionamide
isoniazid
inhA 1674643 p.Asp148Asn missense_variant 0.63 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.6 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.67 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674732 c.531C>T synonymous_variant 0.57 ethionamide
isoniazid
inhA 1674742 p.Lys181Pro missense_variant 0.5 ethionamide
isoniazid
inhA 1674745 c.544_546delTACinsCT frameshift_variant&missense_variant 0.52 ethionamide
isoniazid
inhA 1674750 c.549T>A synonymous_variant 0.54 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674756 c.555T>G synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674759 c.558G>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674765 c.564C>T synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674786 c.585G>C synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.7 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674831 c.630G>A synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674837 c.636C>T synonymous_variant 0.62 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674839 p.Ala213Glu missense_variant 0.62 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.64 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.62 ethionamide
isoniazid Uncertain significance
inhA 1674870 c.669T>C synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674882 c.681G>C synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.61 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674892 p.Asn231Asp missense_variant 0.61 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674904 p.Ala235Pro missense_variant 0.58 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674933 c.732G>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.31 ethionamide
isoniazid
rpsA 1833515 c.-27_-24delCAACinsAAA upstream_gene_variant 0.28 pyrazinamide
rpsA 1833538 c.-3delA upstream_gene_variant 0.45 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.52 pyrazinamide
rpsA 1833554 p.Thr5Ser missense_variant 0.55 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.63 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.64 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.73 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.74 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.75 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.73 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.76 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.74 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.73 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.73 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.73 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.73 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.74 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.77 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.75 pyrazinamide
rpsA 1833739 c.198C>A synonymous_variant 0.77 pyrazinamide
rpsA 1833745 c.204G>T synonymous_variant 0.77 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.78 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.77 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.77 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.76 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.76 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.77 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.76 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.74 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.75 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.75 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.75 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.76 pyrazinamide
rpsA 1833901 c.360G>A synonymous_variant 0.77 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.8 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.77 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.77 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.78 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.78 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.8 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.8 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.78 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.78 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.73 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.75 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.72 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.73 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.75 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.77 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.76 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834282 c.741C>T synonymous_variant 0.78 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.8 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.79 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.8 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.79 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.79 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.81 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834405 c.864C>T synonymous_variant 0.84 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.79 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.83 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.84 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.77 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.73 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.72 pyrazinamide
rpsA 1834556 p.Ala339Gln missense_variant 0.72 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.72 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834650 p.Thr370Ile missense_variant 0.68 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.68 pyrazinamide
rpsA 1834667 c.1126_1128delGCGinsTC frameshift_variant&missense_variant 0.64 pyrazinamide Uncertain significance
rpsA 1834690 c.1149T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834708 c.1167C>T synonymous_variant 0.74 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.64 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.59 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.57 pyrazinamide Uncertain significance
rpsA 1834756 c.1215G>A synonymous_variant 0.57 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.58 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.58 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.57 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.56 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.56 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.56 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.58 linezolid
tsnR 1853370 c.-236_-234delGCAinsTC upstream_gene_variant 0.57 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.55 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.56 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.55 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.55 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.66 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.65 linezolid
tsnR 1853441 c.-165C>T upstream_gene_variant 0.61 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.58 linezolid
tsnR 1853456 c.-150C>T upstream_gene_variant 0.6 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.57 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.57 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.55 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.54 linezolid
tsnR 1853481 c.-125_-123delATCinsGG upstream_gene_variant 0.53 linezolid
tsnR 1853489 c.-117C>T upstream_gene_variant 0.53 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.49 linezolid
tsnR 1853523 c.-83C>A upstream_gene_variant 0.38 linezolid
tsnR 1853528 c.-78G>C upstream_gene_variant 0.38 linezolid
tsnR 1853531 c.-75A>G upstream_gene_variant 0.38 linezolid
tsnR 1853537 c.-69C>T upstream_gene_variant 0.37 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.39 linezolid
tsnR 1853546 c.-60C>G upstream_gene_variant 0.36 linezolid
tsnR 1853552 c.-54C>G upstream_gene_variant 0.33 linezolid
tsnR 1853561 c.-45G>A upstream_gene_variant 0.23 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155572 c.540G>C synonymous_variant 0.97 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.74 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.69 isoniazid
kasA 2517947 c.-168C>T upstream_gene_variant 0.67 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.62 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.62 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.6 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.57 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.44 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.23 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.26 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.31 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.35 isoniazid
kasA 2518171 c.57C>A synonymous_variant 0.39 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.4 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.44 isoniazid
kasA 2518193 p.Pro27Ala missense_variant 0.44 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.53 isoniazid
kasA 2518228 c.114C>A synonymous_variant 0.57 isoniazid
kasA 2518240 c.126C>A synonymous_variant 0.57 isoniazid
kasA 2518245 p.His44Arg missense_variant 0.57 isoniazid
kasA 2518247 p.Ala45Ile missense_variant 0.57 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.58 isoniazid
kasA 2518283 p.Ala57Gln missense_variant 0.55 isoniazid
kasA 2518290 p.Lys59Arg missense_variant 0.52 isoniazid
kasA 2518297 c.183C>T synonymous_variant 0.51 isoniazid
kasA 2518300 c.186T>A synonymous_variant 0.51 isoniazid
kasA 2518312 p.Asp66Glu missense_variant 0.5 isoniazid
kasA 2518316 p.Val68Ile missense_variant 0.49 isoniazid
kasA 2518322 p.Ser70Pro missense_variant 0.46 isoniazid
kasA 2518327 p.His71Gln missense_variant 0.45 isoniazid
kasA 2518331 p.Gly73Ser missense_variant 0.45 isoniazid
kasA 2518336 c.222A>G synonymous_variant 0.44 isoniazid
kasA 2518348 c.234A>C synonymous_variant 0.46 isoniazid
kasA 2518351 c.237C>G synonymous_variant 0.47 isoniazid
kasA 2518357 c.243G>C synonymous_variant 0.47 isoniazid
kasA 2518374 p.Gly87Ala missense_variant 0.35 isoniazid
kasA 2518379 c.265T>C synonymous_variant 0.32 isoniazid
kasA 2518384 c.270G>C synonymous_variant 0.3 isoniazid
kasA 2518385 p.Gly91Ser missense_variant 0.29 isoniazid
kasA 2518390 c.276A>C synonymous_variant 0.27 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.33 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.42 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.47 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.61 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.6 isoniazid
kasA 2518573 c.459G>C synonymous_variant 0.6 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.6 isoniazid
kasA 2518579 c.465T>G synonymous_variant 0.6 isoniazid
kasA 2518585 c.471G>A synonymous_variant 0.62 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.61 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.6 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.59 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.57 isoniazid
kasA 2518630 c.516G>A synonymous_variant 0.58 isoniazid
kasA 2518633 c.519G>C synonymous_variant 0.57 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.56 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.56 isoniazid
kasA 2518651 c.537C>T synonymous_variant 0.57 isoniazid
kasA 2518656 p.Ala181Gly missense_variant 0.55 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.56 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.52 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.51 isoniazid
kasA 2518688 p.Val192Ile missense_variant 0.35 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.24 isoniazid
kasA 2519185 c.1071C>G synonymous_variant 0.33 isoniazid
kasA 2519188 c.1074G>C synonymous_variant 0.38 isoniazid
kasA 2519194 c.1080G>C synonymous_variant 0.42 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.46 isoniazid
kasA 2519227 c.1113G>C synonymous_variant 0.46 isoniazid
kasA 2519236 c.1122G>A synonymous_variant 0.45 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.45 isoniazid
kasA 2519242 c.1128C>G synonymous_variant 0.45 isoniazid
kasA 2519252 p.Ile380Val missense_variant 0.43 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.42 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 0.41 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.42 isoniazid
kasA 2519269 c.1155C>T synonymous_variant 0.4 isoniazid
kasA 2519272 c.1158C>G synonymous_variant 0.41 isoniazid
kasA 2519278 c.1164A>G synonymous_variant 0.38 isoniazid
kasA 2519281 c.1167G>T synonymous_variant 0.39 isoniazid
kasA 2519284 c.1170C>A synonymous_variant 0.41 isoniazid
kasA 2519293 c.1179T>C synonymous_variant 0.41 isoniazid
kasA 2519298 p.Arg395Gln missense_variant 0.39 isoniazid
kasA 2519305 c.1191A>C synonymous_variant 0.38 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.39 isoniazid
kasA 2519329 c.1215C>T synonymous_variant 0.23 isoniazid
kasA 2519332 c.1218C>G synonymous_variant 0.23 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.29 isoniazid
ahpC 2726622 p.Ile144Val missense_variant 0.27 isoniazid
ahpC 2726633 c.441C>G synonymous_variant 0.26 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.25 isoniazid
ahpC 2726648 c.456T>C synonymous_variant 0.25 isoniazid
ahpC 2726657 c.465A>T synonymous_variant 0.24 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.22 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.21 isoniazid
folC 2747224 c.375G>T synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747239 c.360T>C synonymous_variant 0.39 para-aminosalicylic_acid
folC 2747242 c.357G>A synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747272 c.327G>C synonymous_variant 0.58 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.56 para-aminosalicylic_acid
folC 2747278 c.321C>G synonymous_variant 0.56 para-aminosalicylic_acid
folC 2747281 c.318A>G synonymous_variant 0.55 para-aminosalicylic_acid
folC 2747287 c.310_312delCCGinsGC frameshift_variant&missense_variant 0.54 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.54 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.57 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.57 para-aminosalicylic_acid
folC 2747341 c.256_258delGTCinsCG frameshift_variant&missense_variant 0.54 para-aminosalicylic_acid
folC 2747371 c.228C>G synonymous_variant 0.49 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.28 para-aminosalicylic_acid
Rv2477c 2782428 c.1615C>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782444 c.1599G>A synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 p.Gly530Ala missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782465 c.1578G>A synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782495 p.Asp516Glu missense_variant 0.47 ethambutol
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782501 c.1542T>C synonymous_variant 0.47 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782528 c.1515G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782586 p.Leu486Gln missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783173 c.870C>T synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783197 c.846C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783215 c.828G>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783218 c.825C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783236 c.807G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783239 p.Glu268Asp missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Lys missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783245 c.796_798delTTGinsCC frameshift_variant&missense_variant 0.37 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783254 p.Gln263His missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>T synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783339 p.Tyr235Phe missense_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783341 c.702C>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783413 c.630G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783416 c.625_627delATCinsGG frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783425 p.Pro206Lys missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783431 p.Ser204Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783449 c.594C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783456 p.Gln196Leu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783488 c.555G>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCA frameshift_variant&missense_variant 0.41 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783575 c.468G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783599 c.444G>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783629 c.414C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783651 p.His131Ala missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783824 c.219G>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783836 c.207C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783872 c.171G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 p.Lys56Thr missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>A synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783944 c.99G>A synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783947 c.96C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783957 p.Tyr29Leu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 p.Ser27Asn missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783968 p.Thr25Ser missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783986 c.57G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784017 p.Lys9Arg missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784024 p.Thr7Ser missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784025 c.18C>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784034 c.9G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784037 c.6T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859704 c.715T>C synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859714 c.705C>T synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859717 c.702C>G synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859735 c.684G>C synonymous_variant 0.35 clofazimine
bedaquiline
pepQ 2859739 p.Ala227Ser missense_variant 0.33 clofazimine
bedaquiline
pepQ 2859747 c.672C>G synonymous_variant 0.31 clofazimine
bedaquiline
pepQ 2859750 c.669C>T synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859765 c.654G>C synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859771 c.648T>C synonymous_variant 0.28 clofazimine
bedaquiline
pepQ 2859774 c.645C>G synonymous_variant 0.27 clofazimine
bedaquiline
pepQ 2859778 p.Val214Ala missense_variant 0.28 clofazimine
bedaquiline
pepQ 2859781 p.Gln213Ala missense_variant 0.28 clofazimine
bedaquiline
pepQ 2859798 c.621G>C synonymous_variant 0.35 clofazimine
bedaquiline
pepQ 2859822 c.597T>C synonymous_variant 0.31 clofazimine
bedaquiline
pepQ 2859825 c.594C>G synonymous_variant 0.32 clofazimine
bedaquiline
pepQ 2859834 c.585T>G synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859843 c.576G>C synonymous_variant 0.27 clofazimine
bedaquiline
Rv2681 2996918 c.180G>T synonymous_variant 0.21 capreomycin
Rv2681 2996933 c.195C>G synonymous_variant 0.25 capreomycin
Rv2681 2996936 c.198C>T synonymous_variant 0.25 capreomycin
Rv2681 2996940 p.Gly68Asn missense_variant 0.25 capreomycin
Rv2681 2996945 c.207C>G synonymous_variant 0.27 capreomycin
Rv2681 2996951 c.213C>T synonymous_variant 0.27 capreomycin
Rv2681 2996955 c.217_219delATTinsGG frameshift_variant&missense_variant 0.29 capreomycin Uncertain significance
Rv2681 2996966 c.228G>T synonymous_variant 0.37 capreomycin
Rv2681 2996969 c.231G>C synonymous_variant 0.36 capreomycin
Rv2681 2996974 p.Glu79Gly missense_variant 0.36 capreomycin
Rv2681 2996987 c.249A>G synonymous_variant 0.41 capreomycin
Rv2681 2996990 c.252G>C synonymous_variant 0.44 capreomycin
Rv2681 2997004 p.Ser89Asn missense_variant 0.43 capreomycin
Rv2681 2997008 c.270C>T synonymous_variant 0.44 capreomycin
Rv2681 2997021 p.Leu95Val missense_variant 0.44 capreomycin
Rv2681 2997025 p.Thr96Ser missense_variant 0.46 capreomycin
Rv2681 2997027 p.Val97Thr missense_variant 0.46 capreomycin
Rv2681 2997054 p.Ser106Ala missense_variant 0.31 capreomycin
Rv2681 2997060 p.Asn108Asp missense_variant 0.31 capreomycin
Rv2681 2997069 p.Ile111Val missense_variant 0.25 capreomycin
Rv2681 2997078 p.Ser114Ala missense_variant 0.22 capreomycin Uncertain significance
thyX 3067274 c.672C>T synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067283 c.663C>A synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067288 p.Ala220Thr missense_variant 0.33 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067316 p.Arg210Gln missense_variant 0.37 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067331 c.615C>T synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067337 p.His203Gln missense_variant 0.39 para-aminosalicylic_acid
thyX 3067352 p.Met198Ala missense_variant 0.38 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067364 c.582C>T synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067403 c.543C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067418 c.528C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067423 c.523C>T synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067429 p.Ala173Ser missense_variant 0.25 para-aminosalicylic_acid
thyX 3067442 c.504C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067478 c.468C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067631 c.315C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067661 c.283_285delCGCinsAG frameshift_variant&missense_variant 0.45 para-aminosalicylic_acid
thyX 3067669 c.277C>T synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067715 c.229_231delAGCinsTCG synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067760 c.186G>A synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067763 c.181_183delCTCinsGA frameshift_variant&missense_variant 0.56 para-aminosalicylic_acid
thyX 3067770 p.Gly59Ala missense_variant 0.58 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067787 p.Lys53Arg missense_variant 0.53 para-aminosalicylic_acid
thyX 3067790 c.156C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067808 c.138C>T synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067826 c.120C>A synonymous_variant 0.61 para-aminosalicylic_acid
thyX 3067838 c.108C>G synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067841 c.105G>C synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067844 c.102G>C synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067847 c.99C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067856 p.Asp30Glu missense_variant 0.53 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.51 para-aminosalicylic_acid
thyX 3067881 p.Asp22Gly missense_variant 0.46 para-aminosalicylic_acid
thyX 3067885 p.Pro21Ala missense_variant 0.44 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067889 p.Ala19Glu missense_variant 0.42 para-aminosalicylic_acid
thyX 3067894 c.52T>C synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.42 para-aminosalicylic_acid
thyX 3067901 c.45C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067905 p.Lys14Arg missense_variant 0.43 para-aminosalicylic_acid
thyX 3067915 c.31C>T synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067916 c.30A>G synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067945 c.-1delC upstream_gene_variant 0.22 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073887 p.Ser195Asp missense_variant 0.42 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073898 p.Ala192Thr missense_variant 0.46 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.64 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.63 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.66 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.66 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.65 para-aminosalicylic_acid
thyA 3074001 c.471C>A synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.64 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.64 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.65 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.64 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.62 para-aminosalicylic_acid
thyA 3074055 p.Glu139Ala missense_variant 0.61 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3074103 c.369C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyA 3074112 p.Arg120Lys missense_variant 0.51 para-aminosalicylic_acid
thyA 3074115 c.357G>C synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3074121 p.Asp117Glu missense_variant 0.49 para-aminosalicylic_acid
thyA 3074124 c.348G>C synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.52 para-aminosalicylic_acid
thyA 3074154 c.318T>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAC frameshift_variant&missense_variant 0.49 para-aminosalicylic_acid
thyA 3074166 c.306G>C synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074184 c.288A>G synonymous_variant 0.52 para-aminosalicylic_acid
thyA 3074195 p.Ile93Val missense_variant 0.48 para-aminosalicylic_acid
thyA 3074196 c.276G>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074205 c.267A>G synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3074208 c.264C>T synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074235 c.237C>T synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074244 c.228A>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074253 p.His73Gln missense_variant 0.39 para-aminosalicylic_acid
thyA 3074256 c.216G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074262 c.208_210delGGTinsCG frameshift_variant&missense_variant 0.37 para-aminosalicylic_acid
thyA 3074267 p.Ile69Val missense_variant 0.35 para-aminosalicylic_acid
thyA 3074274 c.198T>C synonymous_variant 0.33 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB7 3569220 c.-541C>T upstream_gene_variant 1.0 streptomycin
amikacin
kanamycin
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625069 c.-159T>G upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625075 c.-165G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3625090 c.1524C>T synonymous_variant 0.53 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625093 c.1519_1521delGAGinsAC frameshift_variant&missense_variant 0.52 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625117 c.-207T>G upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.51 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625141 c.-231T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625144 c.-234G>A upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.49 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625162 c.-252T>G upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625165 c.-255G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625168 c.-258G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625174 c.-264C>A upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
lpqB 3625186 c.-276T>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>C upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625207 c.-297C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625537 c.-627T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625540 c.-630G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625570 c.-660G>T upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625573 c.-663G>A upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625587 c.-677C>T upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.51 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3625607 p.Thr336Ile missense_variant 0.52 bedaquiline
rifampicin Uncertain significance
lpqB 3625609 c.-699C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3625620 c.994C>T synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625623 p.Thr331Ser missense_variant 0.5 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrB 3625633 c.981C>T synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625637 p.Ala326Asp missense_variant 0.56 bedaquiline
rifampicin
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.58 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.59 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625657 c.-747C>T upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625663 c.-753G>C upstream_gene_variant 0.63 bedaquiline
rifampicin
lpqB 3625678 c.-768C>G upstream_gene_variant 0.67 bedaquiline
rifampicin
lpqB 3625683 c.-773C>T upstream_gene_variant 0.66 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625695 c.-785C>T upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.62 bedaquiline
rifampicin
lpqB 3625723 c.-813C>G upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.73 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.71 bedaquiline
rifampicin
lpqB 3625765 c.-855C>T upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3625774 c.840G>A synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.61 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625845 p.Ser257Thr missense_variant 0.52 bedaquiline
rifampicin
lpqB 3625846 c.-936G>C upstream_gene_variant 0.51 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3625867 c.747A>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626029 c.585A>G synonymous_variant 0.3 bedaquiline
rifampicin
mtrB 3626035 c.579G>C synonymous_variant 0.31 bedaquiline
rifampicin
mtrB 3626048 p.Arg189Pro missense_variant 0.32 bedaquiline
rifampicin
mtrB 3626054 p.Leu187Ser missense_variant 0.29 bedaquiline
rifampicin
mtrB 3626062 c.552T>C synonymous_variant 0.29 bedaquiline
rifampicin
mtrB 3626065 c.549G>C synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3626077 c.537C>G synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3626080 c.534G>C synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3626092 p.Gly174Thr missense_variant 0.27 bedaquiline
rifampicin
mtrB 3626095 p.Glu173Asp missense_variant 0.27 bedaquiline
rifampicin
mtrB 3626101 p.Gln171His missense_variant 0.27 bedaquiline
rifampicin
mtrB 3626123 p.Ala164Ser missense_variant 0.26 bedaquiline
rifampicin
mtrB 3626126 p.Ala163Val missense_variant 0.25 bedaquiline
rifampicin
mtrB 3626146 p.Gly156Glu missense_variant 0.27 bedaquiline
rifampicin
mtrB 3626149 c.465C>G synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626160 p.Asn152Asp missense_variant 0.2 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 0.98 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626704 c.-91C>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3626711 p.Thr213Gln missense_variant 0.36 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 0.55 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3626753 c.-140G>A upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.62 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626843 c.-230G>A upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626849 c.-236C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626992 c.-379C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627026 c.324G>A synonymous_variant 0.33 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3627032 c.-419G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627035 c.-422G>A upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3627043 p.Ile103Val missense_variant 0.42 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627067 c.-454C>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627092 c.-479C>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627128 c.-515T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627134 c.-521C>T upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627140 c.-527G>A upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627158 c.-545C>T upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627185 c.163_165delTTGinsCC frameshift_variant&missense_variant 0.46 bedaquiline
rifampicin
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.46 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627212 c.-599C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627215 c.-602G>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627224 c.-611G>C upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3627233 c.-620T>G upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627257 c.-644C>T upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627263 c.-650C>A upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrA 3627269 c.81G>A synonymous_variant 0.53 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3627272 c.-659G>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627305 c.43_45delGCTinsCG frameshift_variant&synonymous_variant 0.43 bedaquiline
rifampicin
mtrB 3627308 c.-695C>T upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627320 c.-707C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627325 c.-712T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3627342 p.Thr3Asn missense_variant 0.38 bedaquiline
rifampicin Uncertain significance
mtrB 3627360 c.-747G>T upstream_gene_variant 0.28 bedaquiline
rifampicin
rpoA 3877534 p.Val325Ala missense_variant 0.3 rifampicin
rpoA 3877545 c.963G>C synonymous_variant 0.28 rifampicin
rpoA 3877554 c.954G>C synonymous_variant 0.28 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877563 c.945C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877566 p.Ser314Thr missense_variant 0.27 rifampicin
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.27 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877617 c.891G>C synonymous_variant 0.59 rifampicin
rpoA 3877647 c.861C>T synonymous_variant 0.64 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.67 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.67 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877685 c.823C>T synonymous_variant 0.67 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877740 c.768G>C synonymous_variant 0.78 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877794 c.714G>T synonymous_variant 0.71 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.74 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>C synonymous_variant 0.69 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.66 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.62 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.63 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.64 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878001 c.505_507delTCAinsAGC synonymous_variant 0.59 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.54 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.53 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.51 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.5 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.51 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.52 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.53 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.55 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.56 rifampicin
rpoA 3878064 c.444G>T synonymous_variant 0.58 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.6 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.59 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.66 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.72 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.67 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.62 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.58 rifampicin
rpoA 3878136 c.372C>T synonymous_variant 0.61 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.62 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.67 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>C synonymous_variant 0.74 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.76 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.76 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>T synonymous_variant 0.75 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.73 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.73 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.74 rifampicin
rpoA 3878262 c.244_246delAGCinsGT frameshift_variant&synonymous_variant 0.74 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.75 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.76 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.71 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>C synonymous_variant 0.74 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.69 rifampicin
rpoA 3878358 c.150C>A synonymous_variant 0.67 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.69 rifampicin
rpoA 3878388 c.120C>A synonymous_variant 0.65 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.64 rifampicin
rpoA 3878406 c.102G>T synonymous_variant 0.63 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.61 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.57 rifampicin
rpoA 3878432 c.76C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878436 c.72A>G synonymous_variant 0.54 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.57 rifampicin
rpoA 3878451 c.57C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878454 c.54A>C synonymous_variant 0.43 rifampicin
rpoA 3878459 p.Asn17Asp missense_variant 0.41 rifampicin
rpoA 3878460 p.Asp16Glu missense_variant 0.41 rifampicin
rpoA 3878465 p.Thr15Ala missense_variant 0.42 rifampicin
rpoA 3878466 c.42C>T synonymous_variant 0.46 rifampicin
rpoA 3878469 c.39C>A synonymous_variant 0.43 rifampicin
rpoA 3878472 c.36C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878475 c.33G>A synonymous_variant 0.46 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.5 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.52 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.54 rifampicin
rpoA 3878823 c.-316G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.35 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 0.34 rifampicin
rpoA 3878843 c.-337_-336delCGinsAA upstream_gene_variant 0.33 rifampicin
rpoA 3878845 c.-338G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.49 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878886 c.-379G>A upstream_gene_variant 0.48 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.49 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.48 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.47 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.49 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.48 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.46 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.45 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.43 rifampicin
rpoA 3878942 c.-436_-435delATinsCA upstream_gene_variant 0.41 rifampicin
rpoA 3878944 c.-437G>T upstream_gene_variant 0.41 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878956 c.-449G>A upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878977 c.-470C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878989 c.-482G>A upstream_gene_variant 0.27 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.49 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.5 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.5 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.49 rifampicin
rpoA 3879124 c.-618_-617delTGinsGC upstream_gene_variant 0.51 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.52 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.48 rifampicin
rpoA 3879144 c.-637A>G upstream_gene_variant 0.49 rifampicin
rpoA 3879148 c.-643_-641delGCGinsTC upstream_gene_variant 0.5 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.52 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.52 rifampicin
rpoA 3879192 c.-685G>T upstream_gene_variant 0.46 rifampicin
rpoA 3879196 c.-689C>T upstream_gene_variant 0.42 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879208 c.-701C>G upstream_gene_variant 0.28 rifampicin
ddn 3986615 c.-229C>T upstream_gene_variant 0.76 delamanid
pretomanid
ddn 3986636 c.-208C>A upstream_gene_variant 0.68 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.61 delamanid
pretomanid
ddn 3986667 c.-177_-175delCTCinsACG upstream_gene_variant 0.56 delamanid
pretomanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.53 delamanid
pretomanid
ddn 3986696 c.-148G>T upstream_gene_variant 0.49 delamanid
pretomanid
ddn 3986699 c.-145C>G upstream_gene_variant 0.48 delamanid
pretomanid
ddn 3986714 c.-130C>G upstream_gene_variant 0.34 delamanid
pretomanid
clpC1 4038255 p.Val817Arg missense_variant 0.23 pyrazinamide
clpC1 4038257 c.2448G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.38 pyrazinamide
clpC1 4038272 c.2433T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038290 p.Asp805Glu missense_variant 0.52 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.57 pyrazinamide
clpC1 4038307 p.Val800Ile missense_variant 0.56 pyrazinamide
clpC1 4038310 p.Val799Leu missense_variant 0.56 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038320 c.2385G>A synonymous_variant 0.55 pyrazinamide
clpC1 4038325 p.Val794Ile missense_variant 0.57 pyrazinamide
clpC1 4038329 p.Glu792Asp missense_variant 0.6 pyrazinamide
clpC1 4038335 c.2370C>G synonymous_variant 0.66 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.67 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.68 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.67 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.71 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.73 pyrazinamide
clpC1 4038395 c.2310C>G synonymous_variant 0.74 pyrazinamide
clpC1 4038410 c.2295C>T synonymous_variant 0.73 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.73 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.72 pyrazinamide
clpC1 4038434 p.Ala757Glu missense_variant 0.71 pyrazinamide
clpC1 4038444 p.Ala754Arg missense_variant 0.69 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.7 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.73 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.74 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.72 pyrazinamide
clpC1 4038485 p.Gly740Glu missense_variant 0.67 pyrazinamide
clpC1 4038488 p.Ala739Gly missense_variant 0.66 pyrazinamide
clpC1 4038497 c.2206_2208delAGCinsGT frameshift_variant&synonymous_variant 0.69 pyrazinamide
clpC1 4038523 p.Ile728Val missense_variant 0.66 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.64 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.62 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.62 pyrazinamide
clpC1 4038539 c.2166G>C synonymous_variant 0.63 pyrazinamide
clpC1 4038587 c.2118C>T synonymous_variant 0.72 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.72 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038605 c.2100G>A synonymous_variant 0.69 pyrazinamide
clpC1 4038613 p.Asn698His missense_variant 0.67 pyrazinamide
clpC1 4038614 c.2091C>T synonymous_variant 0.67 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.72 pyrazinamide
clpC1 4038644 p.Glu687Asp missense_variant 0.75 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.74 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.73 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.74 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.76 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4038692 p.Ser671Lys missense_variant 0.74 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.78 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.77 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.82 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.82 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.81 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.83 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.82 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.75 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.79 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.78 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.79 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.8 pyrazinamide
clpC1 4038932 c.1773G>A synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4038941 c.1764G>T synonymous_variant 0.8 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.81 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.81 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.85 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.84 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039031 c.1674T>G synonymous_variant 0.84 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.83 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.83 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.84 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.78 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.77 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.79 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.78 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.78 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.79 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>G synonymous_variant 0.76 pyrazinamide
clpC1 4039292 c.1413C>A synonymous_variant 0.74 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.74 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.74 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.74 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>T synonymous_variant 0.73 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.72 pyrazinamide
clpC1 4039347 p.Arg453Gln missense_variant 0.72 pyrazinamide Uncertain significance
clpC1 4039349 c.1356C>T synonymous_variant 0.72 pyrazinamide
clpC1 4039358 c.1345_1347delAGCinsCG frameshift_variant&missense_variant 0.69 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.7 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.72 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.71 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.65 pyrazinamide
clpC1 4039448 c.1257A>C synonymous_variant 0.64 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1240_1242delCGCinsAG frameshift_variant&missense_variant 0.56 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.72 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.72 pyrazinamide
clpC1 4039570 p.Met379Val missense_variant 0.75 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.73 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4039601 c.1104G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039604 c.1101G>A synonymous_variant 0.8 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.81 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.81 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.72 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.77 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.68 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.66 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.65 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039772 c.933G>A synonymous_variant 0.63 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.63 pyrazinamide
clpC1 4039781 c.924G>T synonymous_variant 0.64 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.66 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.68 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.68 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.74 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.78 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.77 pyrazinamide
clpC1 4039955 c.750G>T synonymous_variant 0.78 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.8 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.78 pyrazinamide
clpC1 4040015 c.690G>A synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4040018 c.687G>C synonymous_variant 0.78 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.78 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.78 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.81 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.69 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>G synonymous_variant 0.63 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.56 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>A synonymous_variant 0.55 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.54 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.54 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.43 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.4 pyrazinamide
clpC1 4040213 p.Ser164Asn missense_variant 0.42 pyrazinamide
clpC1 4040219 c.484_486delTCCinsGG frameshift_variant&missense_variant 0.41 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.46 pyrazinamide
clpC1 4040243 c.462C>T synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040257 p.Ala150Thr missense_variant 0.43 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040270 c.435C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040273 c.432T>A synonymous_variant 0.35 pyrazinamide
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.35 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.53 pyrazinamide
clpC1 4040321 c.384C>T synonymous_variant 0.54 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.54 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.54 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.58 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.57 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.54 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.52 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.54 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.62 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.75 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.75 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.72 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.7 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.7 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040477 c.228G>A synonymous_variant 0.68 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4040525 c.180C>T synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.71 pyrazinamide
clpC1 4040537 c.168G>C synonymous_variant 0.68 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.65 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4040555 c.150G>A synonymous_variant 0.62 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.58 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.54 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.52 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.52 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.52 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.53 pyrazinamide
clpC1 4040594 c.111G>T synonymous_variant 0.52 pyrazinamide
clpC1 4040597 c.108C>A synonymous_variant 0.52 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.54 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.54 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.52 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.42 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.18 pyrazinamide
panD 4044072 c.210C>G synonymous_variant 0.29 pyrazinamide
panD 4044075 c.207T>C synonymous_variant 0.3 pyrazinamide
panD 4044084 c.198T>C synonymous_variant 0.34 pyrazinamide
panD 4044114 c.168C>G synonymous_variant 0.36 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.37 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.38 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.36 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
panD 4044159 c.123C>T synonymous_variant 0.37 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.39 pyrazinamide
panD 4044174 c.108C>G synonymous_variant 0.36 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.33 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.33 pyrazinamide
panD 4044204 c.78G>C synonymous_variant 0.33 pyrazinamide
panD 4044210 c.72C>G synonymous_variant 0.27 pyrazinamide
glpK 4138451 c.1305T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138457 c.1299C>T synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138464 p.Gly431Ala missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138471 p.Ile429Val missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138487 c.1267_1269delTTGinsCC frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138495 p.Gln421Glu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138498 p.Leu420Met missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138500 p.Arg419His missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138505 c.1251T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138514 c.1242A>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138532 c.1224G>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138562 c.1194G>C synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138596 p.Phe387Tyr missense_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.76 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.73 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>A synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138658 c.1098C>G synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138664 c.1092G>C synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138681 p.Met359Val missense_variant 0.76 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138694 p.Pro354Glu missense_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138697 c.1059C>G synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138745 c.1011G>C synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138772 c.984G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>T synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138781 c.975G>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138784 c.972G>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138799 c.957T>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138805 c.951C>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138823 c.933G>T synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138829 c.927A>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138840 p.Val306Leu missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138847 c.909A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138853 c.903C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139215 c.541T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139228 c.528G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139249 c.507C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139262 p.Ala165Asp missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139264 p.Ala164Arg missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139270 c.486C>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139273 c.483A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139276 c.480T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139282 c.474T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139285 p.Glu157Asp missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139288 c.468G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139302 p.Leu152Val missense_variant 0.53 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139312 c.444T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139318 c.438T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139321 c.435T>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139324 c.432A>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139327 c.429G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139348 c.408C>G synonymous_variant 0.58 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139356 p.Leu134Val missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139357 c.397_399delAACinsGT frameshift_variant&missense_variant 0.52 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139360 c.396A>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139363 c.393T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139372 c.384A>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139375 p.Asp127Glu missense_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139381 c.375G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139387 c.369G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139408 c.348T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139417 c.339A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139420 c.336T>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139432 c.324C>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139435 c.321C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139441 c.315A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139447 p.His103Arg missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139453 c.303T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139459 c.297A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139467 p.Thr97Ala missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139474 c.282T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240699 c.837C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4240717 c.855T>C synonymous_variant 0.43 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
embC 4240736 p.Ser292Ala missense_variant 0.52 ethambutol
embC 4240774 c.912C>G synonymous_variant 0.53 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.52 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.52 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.52 ethambutol
embC 4240807 c.945C>G synonymous_variant 0.49 ethambutol Not assoc w R - Interim
embC 4240819 c.957A>C synonymous_variant 0.44 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.43 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.46 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.34 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.36 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.39 ethambutol
embC 4241059 c.1197G>A synonymous_variant 0.53 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.56 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.57 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.61 ethambutol
embC 4241101 c.1239G>C synonymous_variant 0.62 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.63 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.62 ethambutol
embC 4241109 p.Ala416Gly missense_variant 0.62 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.62 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.61 ethambutol Uncertain significance
embC 4241147 p.Cys429Ile missense_variant 0.63 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.6 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.58 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.58 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.6 ethambutol
embC 4241179 c.1317G>C synonymous_variant 0.62 ethambutol
embC 4241188 c.1326C>T synonymous_variant 0.55 ethambutol
embC 4241195 p.Ser445Ala missense_variant 0.51 ethambutol
embC 4241198 p.Ile446Val missense_variant 0.48 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.46 ethambutol
embC 4241212 c.1350G>T synonymous_variant 0.26 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247395 c.882C>G synonymous_variant 0.25 ethambutol
embB 4247398 c.885G>C synonymous_variant 0.25 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.3 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.36 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.39 ethambutol
embB 4247455 c.942C>A synonymous_variant 0.34 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.33 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.33 ethambutol
embB 4247476 c.963C>G synonymous_variant 0.34 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.32 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.31 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.31 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.32 ethambutol
embB 4247528 p.Leu339Met missense_variant 0.26 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.51 ethambutol Not assoc w R - Interim
embB 4248167 c.1654_1656delACCinsGG frameshift_variant&missense_variant 0.52 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.51 ethambutol
embB 4248173 p.Val554Met missense_variant 0.51 ethambutol
embB 4248185 p.Leu558Met missense_variant 0.57 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.61 ethambutol
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.59 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.59 ethambutol
embB 4248217 c.1704C>G synonymous_variant 0.61 ethambutol
embB 4248220 c.1707A>T synonymous_variant 0.63 ethambutol
embB 4248233 c.1720C>T synonymous_variant 0.63 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.66 ethambutol
embB 4248259 p.Met582Ile missense_variant 0.68 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.66 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.68 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.69 ethambutol
embB 4248319 c.1806A>C synonymous_variant 0.7 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.69 ethambutol
embB 4248334 c.1821C>G synonymous_variant 0.69 ethambutol
embB 4248341 p.Thr610Ala missense_variant 0.67 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.64 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.65 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.66 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.67 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.67 ethambutol
embB 4248397 c.1884C>T synonymous_variant 0.6 ethambutol Not assoc w R - Interim
embB 4248403 c.1890G>T synonymous_variant 0.59 ethambutol
embB 4248407 c.1894_1896delTTAinsGG frameshift_variant&missense_variant 0.57 ethambutol
embB 4248430 c.1917T>C synonymous_variant 0.36 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.33 ethambutol
embB 4248436 c.1923C>G synonymous_variant 0.33 ethambutol
embB 4248448 c.1935C>T synonymous_variant 0.32 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
aftB 4269114 c.-278C>G upstream_gene_variant 0.36 ethambutol
aftB 4269123 c.-287T>C upstream_gene_variant 0.44 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.54 ethambutol Not assoc w R - Interim
ubiA 4269149 p.Val229Leu missense_variant 0.54 ethambutol Uncertain significance
aftB 4269156 c.-320C>G upstream_gene_variant 0.58 ethambutol
aftB 4269165 c.-329G>T upstream_gene_variant 0.6 ethambutol
aftB 4269171 c.-335C>G upstream_gene_variant 0.61 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.61 ethambutol
ubiA 4269188 p.Thr216Ser missense_variant 0.61 ethambutol Uncertain significance
aftB 4269189 c.-353C>T upstream_gene_variant 0.61 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.62 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.64 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.64 ethambutol Not assoc w R - Interim
ubiA 4269243 p.His197Gln missense_variant 0.59 ethambutol
aftB 4269246 c.-410G>T upstream_gene_variant 0.58 ethambutol
aftB 4269249 c.-413G>A upstream_gene_variant 0.59 ethambutol
aftB 4269258 c.-422C>G upstream_gene_variant 0.54 ethambutol
aftB 4269261 c.-425G>A upstream_gene_variant 0.54 ethambutol
ubiA 4269271 p.Val188Ala missense_variant 0.49 ethambutol Uncertain significance
aftB 4269291 c.-455A>G upstream_gene_variant 0.35 ethambutol
ubiA 4269297 p.Ile179Met missense_variant 0.26 ethambutol Uncertain significance
aftB 4269302 c.-466C>T upstream_gene_variant 0.2 ethambutol
ethA 4326676 p.Ser266Arg missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R