TB-Profiler result

Run: ERR1063839
Summary

Run ID: ERR1063839

Sample name:

Date: 2024-04-16T01:54:32.534419

Number of reads: 1846473

Percentage reads mapped: 19.12

Median coverage: 26.0

Strain: La2;lineage2.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.74
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
La2 M.caprae None 0.09
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid katG p.Ser140Gly Uncertain significance Mutation from literature
ethambutol embB p.Asp311Gly Mutation from literature
p.Met482Ile Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine pepQ c.594_595insCG Assoc w R - Interim
c.588_589delCG Assoc w R - Interim
para-aminosalicylic_acid
delamanid fgd1 c.166_168delTCCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.202_204delCTGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.205_207delCTGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.508_510delGTGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.562_564delTTGinsCA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.679_681delGGGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.682_684delCTCinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1132_1134delGCGinsTC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1135_1137delGCGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1189_1191delAAAinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiB c.391_393delACCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.594_595insCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.588_589delCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 490948 c.166_168delTCCinsGG frameshift_variant&missense_variant 0.8 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 490984 c.202_204delCTGinsAC frameshift_variant&missense_variant 0.71 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 490987 c.205_207delCTGinsGC frameshift_variant&missense_variant 0.72 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.73 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491290 c.508_510delGTGinsAC frameshift_variant&missense_variant 0.5 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.67 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.71 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.34 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303492 c.562_564delTTGinsCA frameshift_variant&missense_variant 0.38 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303609 c.679_681delGGGinsAC frameshift_variant&missense_variant 0.42 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303612 c.682_684delCTCinsAG frameshift_variant&missense_variant 0.41 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304062 c.1132_1134delGCGinsTC frameshift_variant&missense_variant 0.77 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304065 c.1135_1137delGCGinsAC frameshift_variant&missense_variant 0.77 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304119 c.1189_1191delAAAinsCG frameshift_variant&missense_variant 0.64 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155694 p.Ser140Gly missense_variant 0.69 isoniazid Uncertain significance Mutation from literature
pepQ 2859824 c.594_595insCG frameshift_variant 0.53 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859829 c.588_589delCG frameshift_variant 0.48 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
fbiB 3641925 c.391_393delACCinsGG frameshift_variant&missense_variant 0.41 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247445 p.Asp311Gly missense_variant 0.8 ethambutol Mutation from literature
embB 4247959 p.Met482Ile missense_variant 0.58 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 600 c.600T>C synonymous_variant 0.48 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.58 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.58 isoniazid
dnaA 633 c.633T>G synonymous_variant 0.74 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.74 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.76 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>G synonymous_variant 0.77 isoniazid Not assoc w R - Interim
dnaA 672 c.672T>C synonymous_variant 0.79 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.81 isoniazid Not assoc w R - Interim
dnaA 690 c.690G>C synonymous_variant 0.78 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.84 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.84 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.85 isoniazid
dnaA 714 c.714C>G synonymous_variant 0.86 isoniazid Not assoc w R - Interim
dnaA 735 c.735C>T synonymous_variant 0.84 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.82 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>C synonymous_variant 0.81 isoniazid
dnaA 750 c.750C>G synonymous_variant 0.8 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.81 isoniazid
dnaA 767 p.Val256Ala missense_variant 0.81 isoniazid
dnaA 769 c.769_771delGCAinsTC frameshift_variant&missense_variant 0.81 isoniazid Uncertain significance
dnaA 777 c.777A>G synonymous_variant 0.85 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.85 isoniazid Uncertain significance
dnaA 805 c.805T>C synonymous_variant 0.83 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.79 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.79 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.76 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.75 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.73 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.72 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.71 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.71 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.73 isoniazid Not assoc w R - Interim
dnaA 877 c.877T>C synonymous_variant 0.76 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.73 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.75 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.72 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.72 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.71 isoniazid
dnaA 921 c.921A>C synonymous_variant 0.73 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.74 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.75 isoniazid
dnaA 955 c.955_957delAGAinsCG frameshift_variant&synonymous_variant 0.76 isoniazid Uncertain significance
dnaA 963 c.963C>G synonymous_variant 0.75 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.76 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.77 isoniazid
dnaA 976 c.976C>T synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 984 c.984T>C synonymous_variant 0.76 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>C synonymous_variant 0.74 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.74 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.73 isoniazid
dnaA 1002 c.1002G>A synonymous_variant 0.76 isoniazid
dnaA 1014 c.1014C>G synonymous_variant 0.74 isoniazid
dnaA 1020 c.1020C>G synonymous_variant 0.66 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.64 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.49 isoniazid
dnaA 1038 c.1038A>G synonymous_variant 0.45 isoniazid
dnaA 1098 c.1098A>G synonymous_variant 0.28 isoniazid
gyrB 6178 c.939C>T synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrB 6203 p.Ser322Ala missense_variant 0.68 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAGC synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.74 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.75 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6362 c.1123_1125delTTGinsCC frameshift_variant&missense_variant 0.73 levofloxacin Uncertain significance
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.66 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrB 6397 c.1158G>A synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6398 p.Val387Ile missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrB 6416 p.Thr393Gly missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6430 c.-872A>G upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrB 6440 p.Thr401Ala missense_variant 0.68 levofloxacin
moxifloxacin
gyrB 6445 p.Asp402Glu missense_variant 0.7 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6452 p.Val405Thr missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6472 c.-830G>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrA 6478 c.-824G>C upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrB 6487 c.1248C>G synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6490 c.-812T>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6496 c.-806G>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6508 c.-794A>G upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6511 c.-791A>T upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>T upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>C upstream_gene_variant 0.72 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6571 c.-731T>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6604 c.-698G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrB 6608 p.Val457Ile missense_variant 0.79 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.81 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>C upstream_gene_variant 0.79 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 6628 c.-674C>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.81 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>G upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.87 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.87 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6733 c.-569G>A upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6763 c.-539G>A upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.72 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.76 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6860 p.Ser541Ala missense_variant 0.74 levofloxacin
moxifloxacin
gyrA 6868 c.-434G>A upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6896 p.Arg553Lys missense_variant 0.83 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6922 c.1683G>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6924 p.Phe562Tyr missense_variant 0.83 levofloxacin
moxifloxacin
gyrB 6926 c.1687T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6955 c.-347G>A upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6961 c.-341G>A upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrB 6970 p.Asp577Glu missense_variant 0.8 levofloxacin
moxifloxacin
gyrB 6973 c.1734G>A synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6982 c.-320A>C upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrA 6988 c.-314C>G upstream_gene_variant 0.78 levofloxacin
moxifloxacin
gyrB 7005 p.Gly589Ala missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrB 7025 p.Lys596Ala missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 7343 c.42G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.8 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7532 c.231T>G synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 7658 c.357A>C synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7664 c.363T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7691 c.390C>A synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7700 c.399G>A synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7710 c.409T>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 7733 c.432A>G synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7748 c.447A>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7758 c.457_459delATCinsGA frameshift_variant&missense_variant 0.72 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7821 c.520C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 7906 p.Phe202Tyr missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8187 c.886_888delCTGinsAC frameshift_variant&missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8199 p.Ser300Ala missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 8207 c.906T>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.69 levofloxacin
moxifloxacin
gyrA 8258 c.957G>A synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8310 c.1009C>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.86 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.81 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8402 c.1101C>T synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251_1254delCCGGinsGC frameshift_variant&synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8559 c.1258_1260delGGAinsAGGGC frameshift_variant&missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 8588 p.Glu429Asp missense_variant 0.78 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8651 c.1350C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.82 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8711 c.1410A>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>G synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Lys missense_variant 0.74 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.77 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.79 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.82 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>A synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.89 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.88 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.85 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9113 c.1812C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9206 c.1905C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9207 p.Lys636Arg missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.78 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9263 c.1962C>T synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9267 p.Asn656Gly missense_variant 0.77 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 9287 c.1986G>T synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9311 c.2010C>T synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 9419 c.2118T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Ala missense_variant 0.81 levofloxacin
moxifloxacin
gyrA 9464 c.2163C>A synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9476 c.2175G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 9479 c.2178G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 9485 c.2184A>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 9488 c.2187G>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 9494 c.2193T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 9497 c.2196G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9500 c.2199A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9503 c.2202T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9506 c.2205C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 9509 c.2208G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9518 c.2217A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9521 c.2220C>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9527 c.2226A>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9542 c.2241T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9548 c.2247T>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9558 p.Val753Ile missense_variant 0.21 levofloxacin
moxifloxacin
fgd1 490821 c.39A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490824 c.42A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490830 c.48A>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 490853 p.Ala24Gly missense_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 490859 p.Ala26Glu missense_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 490869 c.87C>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 490899 c.117C>T synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>T synonymous_variant 0.79 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490921 p.Gln47Glu missense_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 490968 c.186C>T synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 490971 c.189A>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 490980 p.Asn66Lys missense_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491010 c.228C>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491016 c.234C>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491037 c.255C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 491073 c.291C>T synonymous_variant 0.72 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491077 p.Asn99Asp missense_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>A synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491133 c.351A>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491187 c.405G>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Leu missense_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491223 c.441C>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491226 c.444C>G synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491249 p.Arg156His missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491251 p.Leu157Thr missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491262 c.480C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.54 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491295 c.513C>G synonymous_variant 0.5 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491302 p.Ile174Val missense_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>T synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 491321 p.Ala180Val missense_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>A synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>T synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491346 c.564C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.59 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491355 c.573C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491364 c.582T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491370 c.588C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491379 c.597C>T synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491453 p.Gly224Asp missense_variant 0.42 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491461 p.Lys227Arg missense_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491487 c.705C>T synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fgd1 491502 p.Glu240Asp missense_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491521 c.739C>A synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>A synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491655 c.873C>T synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>T synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491697 c.915G>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575618 c.271C>A synonymous_variant 0.38 ethionamide
isoniazid
mshA 575626 c.279C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575627 p.Ala94Ser missense_variant 0.26 ethionamide
isoniazid
mshA 575644 c.297G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575652 p.Arg102Pro missense_variant 0.36 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.4 ethionamide
isoniazid
mshA 575665 c.318G>A synonymous_variant 0.39 ethionamide
isoniazid
mshA 575671 c.324G>C synonymous_variant 0.43 ethionamide
isoniazid
mshA 575683 c.336G>C synonymous_variant 0.55 ethionamide
isoniazid
mshA 575689 c.342G>C synonymous_variant 0.57 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.63 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.69 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.77 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.77 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.74 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>G synonymous_variant 0.75 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.76 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.8 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.81 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.83 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.85 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.82 ethionamide
isoniazid
mshA 575842 c.495G>A synonymous_variant 0.79 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.79 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.79 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.79 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.72 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.69 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.32 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575917 p.Asp190Glu missense_variant 0.68 ethionamide
isoniazid
mshA 575920 c.573C>T synonymous_variant 0.65 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575925 p.Gly193Ala missense_variant 0.63 ethionamide
isoniazid
mshA 575929 c.582C>G synonymous_variant 0.63 ethionamide
isoniazid
mshA 575932 c.585G>A synonymous_variant 0.65 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.57 ethionamide
isoniazid
mshA 575945 p.Thr200Ala missense_variant 0.56 ethionamide
isoniazid
mshA 575953 c.606G>C synonymous_variant 0.56 ethionamide
isoniazid
mshA 575956 c.609G>A synonymous_variant 0.56 ethionamide
isoniazid
mshA 575974 c.627G>A synonymous_variant 0.48 ethionamide
isoniazid
mshA 575977 c.630G>C synonymous_variant 0.48 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 576397 c.1050C>T synonymous_variant 0.31 ethionamide
isoniazid
mshA 576403 c.1056C>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 576421 c.1074T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 576424 c.1077T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 576425 c.1078_1080delGTGinsAC frameshift_variant&missense_variant 0.32 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 576433 c.1086C>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 576439 c.1092G>A synonymous_variant 0.32 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 576448 c.1101A>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 576454 c.1107G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 576460 c.1113C>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 576463 c.1116G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 576469 c.1122G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 576499 c.1152G>C synonymous_variant 0.38 ethionamide
isoniazid Not assoc w R - Interim
mshA 576500 p.Ile385Val missense_variant 0.38 ethionamide
isoniazid
ccsA 619570 c.-321G>C upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619576 c.-315C>G upstream_gene_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 619601 c.-290G>A upstream_gene_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 619607 c.-284C>G upstream_gene_variant 0.63 capreomycin
amikacin
kanamycin
ccsA 619615 c.-276C>G upstream_gene_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 619629 c.-262G>C upstream_gene_variant 0.61 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257_-256delTCinsGT upstream_gene_variant 0.61 capreomycin
amikacin
kanamycin
ccsA 619648 c.-243C>G upstream_gene_variant 0.71 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.71 capreomycin
amikacin
kanamycin
ccsA 619657 c.-234C>G upstream_gene_variant 0.72 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>T upstream_gene_variant 0.74 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>G upstream_gene_variant 0.74 capreomycin
amikacin
kanamycin
ccsA 619696 c.-195C>G upstream_gene_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 619697 c.-194_-192delAGGinsCA upstream_gene_variant 0.62 capreomycin
amikacin
kanamycin
ccsA 619702 c.-189C>A upstream_gene_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 619706 c.-185_-183delGTGinsAC upstream_gene_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 619713 c.-178C>T upstream_gene_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 619723 c.-168G>C upstream_gene_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 619727 c.-164delAinsGC upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619732 c.-158delG upstream_gene_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 619746 c.-145A>G upstream_gene_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 619762 c.-129C>G upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619763 c.-128C>T upstream_gene_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 619766 c.-125_-123delACGinsGC upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619774 c.-117C>G upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619783 c.-108C>G upstream_gene_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 619794 c.-97C>A upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620238 c.348G>C synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620247 p.Leu119Phe missense_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620264 p.Gly125Ala missense_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620271 c.381C>G synonymous_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620296 p.Pro136Thr missense_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620311 p.Leu141Val missense_variant 0.61 capreomycin
amikacin
kanamycin
ccsA 620316 c.426G>C synonymous_variant 0.63 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620337 c.447C>G synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.58 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>T synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.67 capreomycin
amikacin
kanamycin
ccsA 620379 c.489G>C synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>T synonymous_variant 0.71 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620409 c.519C>G synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.74 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>G synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620442 c.552G>C synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>G synonymous_variant 0.71 capreomycin
amikacin
kanamycin
ccsA 620463 c.573C>G synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620583 c.693G>C synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620586 c.696C>A synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.65 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.66 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.98 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>G synonymous_variant 0.75 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.76 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 0.78 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>T synonymous_variant 0.82 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620670 c.780C>T synonymous_variant 0.83 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620709 c.819G>C synonymous_variant 0.74 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.74 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.75 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620736 c.846G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>G synonymous_variant 0.67 capreomycin
amikacin
kanamycin
ccsA 620754 c.864G>C synonymous_variant 0.63 capreomycin
amikacin
kanamycin
ccsA 620758 p.Arg290Lys missense_variant 0.61 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>A synonymous_variant 0.44 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 0.95 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657581 c.-111G>C upstream_gene_variant 0.33 ethionamide
Rv0565c 657596 c.-126G>C upstream_gene_variant 0.54 ethionamide
Rv0565c 657619 c.-149C>T upstream_gene_variant 0.63 ethionamide
Rv0565c 657620 c.-150C>T upstream_gene_variant 0.64 ethionamide
Rv0565c 657635 c.-167_-165delAGCinsTCG upstream_gene_variant 0.63 ethionamide
Rv0565c 657640 c.-170A>T upstream_gene_variant 0.64 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.64 ethionamide
Rv0565c 657647 c.-177C>G upstream_gene_variant 0.64 ethionamide
Rv0565c 657670 c.-200A>G upstream_gene_variant 0.72 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.72 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.74 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.73 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.72 ethionamide
hadA 731717 c.-213T>C upstream_gene_variant 0.23 isoniazid
hadA 731723 c.-207T>C upstream_gene_variant 0.3 isoniazid
hadA 731730 c.-200_-198delGTGinsAC upstream_gene_variant 0.33 isoniazid
hadA 731738 c.-192G>C upstream_gene_variant 0.5 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.5 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.52 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.52 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.49 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 0.51 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.5 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.51 isoniazid
hadA 731823 c.-107_-105delCTGinsAC upstream_gene_variant 0.51 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.4 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.4 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.38 isoniazid
hadA 732265 c.336G>T synonymous_variant 0.4 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.4 isoniazid
hadA 732269 p.Glu114Gln missense_variant 0.4 isoniazid
hadA 732281 p.Thr118Ala missense_variant 0.43 isoniazid
hadA 732284 c.355_357delCAGinsGC frameshift_variant&missense_variant 0.43 isoniazid Uncertain significance
hadA 732305 p.Ile126Val missense_variant 0.44 isoniazid
hadA 732320 c.391_393delGAAinsAC frameshift_variant&missense_variant 0.4 isoniazid Uncertain significance
hadA 732331 c.402C>G synonymous_variant 0.39 isoniazid
hadA 732343 c.414C>G synonymous_variant 0.41 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.41 isoniazid
nusG 734397 p.Asp48Glu missense_variant 0.69 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.73 rifampicin
nusG 734413 c.160_161delTCinsAG synonymous_variant 0.72 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.7 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.68 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.77 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.83 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.81 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.82 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.81 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.81 rifampicin
nusG 734505 c.252G>C synonymous_variant 0.79 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.68 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.43 rifampicin
nusG 734802 c.549C>G synonymous_variant 0.46 rifampicin
nusG 734807 p.Tyr185Phe missense_variant 0.49 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.7 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
nusG 734847 c.594T>C synonymous_variant 0.72 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.72 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.72 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.72 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.7 rifampicin
nusG 734862 c.609C>G synonymous_variant 0.72 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.72 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.73 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.69 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.68 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.57 rifampicin
nusG 734934 c.681G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
nusG 734940 c.687G>A synonymous_variant 0.29 rifampicin
rpoB 760130 c.324T>C synonymous_variant 0.39 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760140 p.Pro112Ser missense_variant 0.48 rifampicin
rpoB 760148 c.342C>T synonymous_variant 0.6 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760208 p.Ile134Met missense_variant 0.83 rifampicin
rpoB 760212 p.Asn136Ala missense_variant 0.84 rifampicin
rpoB 760215 c.409_411delAACinsGG frameshift_variant&missense_variant 0.84 rifampicin
rpoB 760219 p.Thr138Ser missense_variant 0.85 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.86 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.86 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.84 rifampicin
rpoB 760317 c.511_513delAGCinsTCG synonymous_variant 0.85 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.86 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.87 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.89 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.86 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.86 rifampicin Uncertain significance
rpoB 760424 c.618C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760454 c.648C>G synonymous_variant 0.86 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.83 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.81 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.78 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760551 c.745_746delTCinsAG synonymous_variant 0.74 rifampicin
rpoB 760563 c.757delCinsAT frameshift_variant&synonymous_variant 0.72 rifampicin
rpoB 760566 p.Ser254Ala missense_variant 0.71 rifampicin
rpoB 760567 c.762delG frameshift_variant 0.71 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.79 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.83 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760747 c.942C>G synonymous_variant 0.44 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.31 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.67 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.71 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.76 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.77 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.76 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>G synonymous_variant 0.73 rifampicin
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.71 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.71 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.72 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.74 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.79 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.81 rifampicin
rpoB 761217 c.1411_1413delCCGinsGC frameshift_variant&missense_variant 0.78 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.8 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.87 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.88 rifampicin
rpoB 761357 c.1551G>T synonymous_variant 0.87 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.87 rifampicin
rpoB 761375 c.1569G>C synonymous_variant 0.86 rifampicin
rpoB 761403 p.His533Tyr missense_variant 0.76 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.72 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.61 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.88 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.89 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.89 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.87 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.77 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.76 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.73 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.71 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.71 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.64 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.53 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsAC frameshift_variant&missense_variant 0.53 rifampicin
rpoB 761727 p.Ser641Ala missense_variant 0.53 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.59 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.7 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.7 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.76 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.74 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.76 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.79 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.78 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.8 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.83 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.84 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.85 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.85 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.86 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.85 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.85 rifampicin
rpoB 761903 c.2097T>G synonymous_variant 0.83 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.83 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.84 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.82 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.82 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.82 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.88 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.87 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.89 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.9 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.9 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.9 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.89 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762249 c.2443C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.92 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.93 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.91 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.91 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.89 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.88 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.88 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.87 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.87 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.87 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.86 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.81 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.82 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.81 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.81 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.79 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.73 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.74 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.73 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.7 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.69 rifampicin
rpoB 762537 c.2731_2733delTTGinsCC frameshift_variant&missense_variant 0.7 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.73 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.73 rifampicin
rpoC 762765 c.-605C>T upstream_gene_variant 0.35 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.5 rifampicin Uncertain significance
rpoB 762786 p.Val994Lys missense_variant 0.49 rifampicin
rpoB 762798 p.Ala998Ser missense_variant 0.63 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762820 p.Phe1005Tyr missense_variant 0.79 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.87 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.89 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.88 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.88 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.86 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763179 c.-191C>T upstream_gene_variant 0.85 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.79 rifampicin
rpoC 763205 c.-165G>T upstream_gene_variant 0.78 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.78 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763217 c.-153G>C upstream_gene_variant 0.79 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.79 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.79 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.77 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.8 rifampicin
rpoC 763250 c.-120C>T upstream_gene_variant 0.8 rifampicin
rpoC 763251 c.-119C>T upstream_gene_variant 0.8 rifampicin
rpoC 763259 c.-111G>C upstream_gene_variant 0.81 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.69 rifampicin
rpoC 763289 c.-81C>G upstream_gene_variant 0.67 rifampicin
rpoC 763375 c.6C>A synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763396 c.27A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.85 rifampicin
rpoC 763405 c.36C>T synonymous_variant 0.84 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.87 rifampicin
rpoC 763417 c.48C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.91 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.9 rifampicin
rpoC 763447 c.78C>T synonymous_variant 0.88 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.92 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.89 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.91 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.91 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.91 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.92 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.91 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.92 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.9 rifampicin
rpoC 763768 c.399C>T synonymous_variant 0.89 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.88 rifampicin
rpoC 763781 p.Ser138Glu missense_variant 0.87 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.85 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.86 rifampicin
rpoC 763822 c.453C>G synonymous_variant 0.86 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.86 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.83 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.81 rifampicin
rpoC 763849 c.480G>A synonymous_variant 0.78 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.75 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.73 rifampicin
rpoC 763867 c.498C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763870 c.501C>T synonymous_variant 0.65 rifampicin
rpoC 763871 p.Gly168Ser missense_variant 0.64 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.64 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.66 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.72 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.75 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763910 p.Leu181Met missense_variant 0.76 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.81 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.77 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.78 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.85 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.87 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.88 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.86 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.87 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.86 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.82 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.82 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Gln missense_variant 0.79 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.84 rifampicin
rpoC 764146 c.777G>A synonymous_variant 0.77 rifampicin
rpoC 764147 c.778_780delTCGinsGC frameshift_variant&missense_variant 0.76 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.77 rifampicin
rpoC 764156 p.Lys263Arg missense_variant 0.77 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.81 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.81 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.81 rifampicin Uncertain significance
rpoC 764215 c.846A>T synonymous_variant 0.82 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.83 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.81 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.82 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.82 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764269 c.900G>T synonymous_variant 0.82 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.83 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764285 p.Gly306Ser missense_variant 0.83 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.79 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.84 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.85 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.85 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.86 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764452 c.1083T>C synonymous_variant 0.93 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>T synonymous_variant 0.94 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.93 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.92 rifampicin
rpoC 764585 c.1216_1218delCTCinsTG frameshift_variant&missense_variant 0.92 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.92 rifampicin
rpoC 764713 c.1344G>A synonymous_variant 0.93 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.94 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.93 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764857 c.1488G>T synonymous_variant 0.94 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.94 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.92 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.91 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.91 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.88 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 0.79 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.79 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.8 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.79 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.66 rifampicin
rpoC 765122 c.1753C>T synonymous_variant 0.53 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765357 p.Met663Thr missense_variant 0.6 rifampicin
rpoC 765359 p.Ala664Thr missense_variant 0.64 rifampicin
rpoC 765367 c.1998C>G synonymous_variant 0.69 rifampicin
rpoC 765397 c.2028G>T synonymous_variant 0.81 rifampicin
rpoC 765402 c.2035_2038delCTGG frameshift_variant 0.81 rifampicin
rpoC 765409 c.2041_2042insCAGT frameshift_variant 0.8 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.83 rifampicin
rpoC 765451 c.2082C>G synonymous_variant 0.82 rifampicin
rpoC 765452 p.Ala695Arg missense_variant 0.83 rifampicin
rpoC 765458 p.Ile697Val missense_variant 0.84 rifampicin Uncertain significance
rpoC 765466 c.2097C>T synonymous_variant 0.85 rifampicin
rpoC 765478 c.2109T>G synonymous_variant 0.86 rifampicin
rpoC 765496 c.2127C>G synonymous_variant 0.85 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.78 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.79 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.78 rifampicin
rpoC 765590 p.Arg741Glu missense_variant 0.67 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.67 rifampicin
rpoC 765610 p.Asp747Glu missense_variant 0.47 rifampicin Uncertain significance
rpoC 765612 p.His748Arg missense_variant 0.43 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.61 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.77 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.79 rifampicin
rpoC 765805 c.2436C>G synonymous_variant 0.82 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.93 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.93 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.94 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.93 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>T synonymous_variant 0.92 rifampicin
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.92 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.87 rifampicin
rpoC 766012 c.2643C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.81 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.71 rifampicin
rpoC 766270 c.2901G>C synonymous_variant 0.28 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.26 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.37 rifampicin
rpoC 766298 p.Thr977Leu missense_variant 0.51 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.64 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.64 rifampicin
rpoC 766324 c.2955C>G synonymous_variant 0.64 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.68 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.76 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.81 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.81 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.82 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.85 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.87 rifampicin
rpoC 766423 c.3054T>C synonymous_variant 0.81 rifampicin
rpoC 766428 c.3060_3061insACC conservative_inframe_insertion 0.85 rifampicin
rpoC 766432 c.3063T>C synonymous_variant 0.83 rifampicin
rpoC 766434 c.3065_3066delAGinsGCAGC missense_variant&conservative_inframe_insertion 0.83 rifampicin
rpoC 766456 c.3087C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766459 c.3090G>C synonymous_variant 0.83 rifampicin
rpoC 766480 c.3111C>A synonymous_variant 0.79 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.78 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.78 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.77 rifampicin
rpoC 766494 p.Gly1042Asp missense_variant 0.77 rifampicin Uncertain significance
rpoC 766517 p.Thr1050Ser missense_variant 0.64 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.61 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.59 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.6 rifampicin
rpoC 766537 c.3168G>A synonymous_variant 0.63 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.63 rifampicin
rpoC 766546 c.3177G>A synonymous_variant 0.64 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.64 rifampicin
rpoC 766568 c.3199_3201delGTTinsAC frameshift_variant&missense_variant 0.42 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.4 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.34 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.57 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.6 rifampicin
rpoC 766652 p.Ser1095Thr missense_variant 0.6 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.62 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.61 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.68 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.8 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.86 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.88 rifampicin
rpoC 766733 c.3364C>T synonymous_variant 0.89 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.89 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.9 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.89 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.89 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.89 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.89 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.89 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>G synonymous_variant 0.85 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.83 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.86 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.86 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.87 rifampicin
rpoC 766907 c.3538C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766911 p.Ile1181Thr missense_variant 0.85 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.86 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766942 c.3573C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>T synonymous_variant 0.85 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>T synonymous_variant 0.89 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.91 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767074 c.3705T>C synonymous_variant 0.91 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767155 c.3786C>G synonymous_variant 0.86 rifampicin
rpoC 767161 c.3792C>T synonymous_variant 0.84 rifampicin
rpoC 767162 p.Asn1265Pro missense_variant 0.85 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.87 rifampicin
rpoC 767197 c.3828G>A synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 767260 c.3891C>T synonymous_variant 0.75 rifampicin
rpoC 767263 c.3894T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.76 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.76 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775829 c.2652C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775832 c.2649C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775835 c.2646C>G synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775847 c.2634G>C synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.57 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.63 clofazimine
bedaquiline
mmpL5 775874 c.2607C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775886 c.2595A>C synonymous_variant 0.7 clofazimine
bedaquiline
mmpL5 775895 c.2584_2586delATCinsCG frameshift_variant&missense_variant 0.58 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775898 c.2583G>A synonymous_variant 0.57 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775907 c.2574C>G synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775910 c.2571G>C synonymous_variant 0.59 clofazimine
bedaquiline
mmpL5 775913 c.2568C>A synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.72 clofazimine
bedaquiline
mmpL5 775937 c.2542_2544delGCGinsTC frameshift_variant&missense_variant 0.39 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775940 c.2541C>T synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 775943 c.2538C>G synonymous_variant 0.63 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.78 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.69 clofazimine
bedaquiline
mmpL5 775952 c.2529G>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.52 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.71 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.75 clofazimine
bedaquiline
mmpL5 775983 p.Trp833Leu missense_variant 0.27 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.55 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.71 clofazimine
bedaquiline
mmpL5 776000 c.2481G>C synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.54 clofazimine
bedaquiline
mmpL5 776015 c.2464_2466delATCinsCG frameshift_variant&missense_variant 0.42 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776023 p.Val820Met missense_variant 0.25 clofazimine
bedaquiline
mmpL5 776030 c.2451G>C synonymous_variant 0.64 clofazimine
bedaquiline
mmpL5 776053 p.Leu810Val missense_variant 0.49 clofazimine
bedaquiline
mmpL5 776060 c.2421C>G synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 776072 c.2409C>G synonymous_variant 0.49 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 776078 c.2403C>G synonymous_variant 0.48 clofazimine
bedaquiline
mmpL5 776081 c.2400G>C synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 776087 c.2394C>G synonymous_variant 0.48 clofazimine
bedaquiline
mmpL5 776093 c.2388C>A synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 0.97 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776102 c.2377_2379delATCinsCG frameshift_variant&missense_variant 0.39 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776182 p.Asp767Asn missense_variant 0.94 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.96 clofazimine
bedaquiline
rpsL 781134 c.-426T>C upstream_gene_variant 0.32 streptomycin
rpsL 781138 c.-422C>G upstream_gene_variant 0.37 streptomycin
rpsL 781143 c.-417T>G upstream_gene_variant 0.37 streptomycin
rpsL 781158 c.-402C>G upstream_gene_variant 0.38 streptomycin
rpsL 781164 c.-396T>C upstream_gene_variant 0.36 streptomycin
rpsL 781173 c.-387A>G upstream_gene_variant 0.39 streptomycin
rpsL 781174 c.-386C>A upstream_gene_variant 0.37 streptomycin
rpsL 781179 c.-381T>C upstream_gene_variant 0.38 streptomycin
rpsL 781182 c.-378G>C upstream_gene_variant 0.39 streptomycin
rpsL 781185 c.-375T>C upstream_gene_variant 0.39 streptomycin
rpsL 781189 c.-371T>C upstream_gene_variant 0.39 streptomycin
rpsL 781197 c.-363A>G upstream_gene_variant 0.39 streptomycin
rpsL 781206 c.-354C>G upstream_gene_variant 0.4 streptomycin
rpsL 781208 c.-352_-351delTCinsCG upstream_gene_variant 0.41 streptomycin
rpsL 781217 c.-343A>G upstream_gene_variant 0.43 streptomycin
rpsL 781224 c.-336T>C upstream_gene_variant 0.43 streptomycin
rpsL 781230 c.-330T>C upstream_gene_variant 0.41 streptomycin
rpsL 781231 c.-329G>A upstream_gene_variant 0.41 streptomycin
rpsL 781252 c.-308C>A upstream_gene_variant 0.33 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.43 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.43 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.47 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.49 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.68 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.79 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.78 streptomycin
rpsL 781718 c.159C>A synonymous_variant 0.8 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.79 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.79 streptomycin
rpsL 781735 p.Ser59Thr missense_variant 0.79 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.82 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.82 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.81 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.81 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.85 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.86 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.87 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.86 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.86 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.88 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.86 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.85 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.85 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.86 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.86 streptomycin
rpsL 781904 c.345C>T synonymous_variant 0.83 streptomycin Not assoc w R - Interim
rpsL 781907 c.348T>C synonymous_variant 0.83 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.82 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.79 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.49 linezolid
rplC 800531 c.-278T>C upstream_gene_variant 0.68 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.7 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.72 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.75 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.8 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.8 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.79 linezolid
rplC 800579 c.-230C>G upstream_gene_variant 0.8 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.8 linezolid
rplC 800585 c.-224T>C upstream_gene_variant 0.82 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.83 linezolid
rplC 800597 c.-212A>C upstream_gene_variant 0.83 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.84 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.85 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.84 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.86 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.83 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.81 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.82 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.82 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.78 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.78 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.79 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.79 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.79 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.8 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.78 linezolid
rplC 800774 c.-35C>T upstream_gene_variant 0.77 linezolid
rplC 800799 c.-10_-8delGGAinsC upstream_gene_variant 0.78 linezolid
rplC 800807 c.-2C>A upstream_gene_variant 0.74 linezolid
rplC 800814 c.6A>T synonymous_variant 0.73 linezolid
rplC 800815 c.7_9delCGAinsAG frameshift_variant&synonymous_variant 0.72 linezolid
rplC 800829 c.21C>G synonymous_variant 0.76 linezolid
rplC 800832 c.24T>C synonymous_variant 0.76 linezolid
rplC 800844 c.36T>C synonymous_variant 0.79 linezolid
rplC 800856 c.48A>G synonymous_variant 0.79 linezolid
rplC 800865 c.57A>G synonymous_variant 0.77 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.76 linezolid
rplC 800874 c.66A>G synonymous_variant 0.75 linezolid
rplC 800877 c.69A>C synonymous_variant 0.75 linezolid
rplC 800880 c.72A>G synonymous_variant 0.75 linezolid
rplC 800889 c.81C>T synonymous_variant 0.8 linezolid Not assoc w R - Interim
rplC 800892 c.84G>C synonymous_variant 0.81 linezolid
rplC 800904 c.96G>C synonymous_variant 0.81 linezolid
rplC 800913 c.105G>C synonymous_variant 0.8 linezolid
rplC 800916 c.108A>C synonymous_variant 0.81 linezolid
rplC 800919 c.111C>G synonymous_variant 0.81 linezolid
rplC 800931 c.123G>T synonymous_variant 0.83 linezolid
rplC 800937 c.129A>G synonymous_variant 0.82 linezolid
rplC 800946 c.138T>C synonymous_variant 0.81 linezolid
rplC 800949 c.141T>C synonymous_variant 0.83 linezolid
rplC 800970 c.162T>C synonymous_variant 0.81 linezolid Not assoc w R - Interim
rplC 800981 p.Ser58Asn missense_variant 0.77 linezolid
rplC 800985 c.177A>G synonymous_variant 0.76 linezolid
rplC 800994 c.186C>G synonymous_variant 0.76 linezolid
rplC 801008 p.Thr67Lys missense_variant 0.65 linezolid
rplC 801019 p.Thr71Glu missense_variant 0.53 linezolid
rplC 801027 c.219C>G synonymous_variant 0.5 linezolid
rplC 801039 c.231A>G synonymous_variant 0.47 linezolid
rplC 801045 c.237A>T synonymous_variant 0.36 linezolid
rplC 801046 p.Tyr80His missense_variant 0.33 linezolid
rplC 801051 c.243G>C synonymous_variant 0.33 linezolid
rplC 801054 c.246G>C synonymous_variant 0.35 linezolid
rplC 801063 c.255G>C synonymous_variant 0.23 linezolid
rplC 801117 c.309G>C synonymous_variant 0.37 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.52 linezolid
rplC 801132 c.324T>C synonymous_variant 0.57 linezolid
rplC 801156 c.348T>C synonymous_variant 0.7 linezolid
rplC 801160 c.352_353delTCinsAG synonymous_variant 0.68 linezolid
rplC 801171 c.363A>G synonymous_variant 0.69 linezolid
rplC 801174 c.366T>C synonymous_variant 0.72 linezolid
rplC 801180 c.372C>G synonymous_variant 0.73 linezolid
rplC 801195 c.387G>C synonymous_variant 0.77 linezolid
rplC 801201 c.393C>T synonymous_variant 0.8 linezolid
rplC 801210 c.402T>C synonymous_variant 0.82 linezolid
rplC 801222 c.414T>C synonymous_variant 0.82 linezolid
rplC 801228 c.420T>C synonymous_variant 0.81 linezolid
rplC 801229 p.Ala141Thr missense_variant 0.81 linezolid
rplC 801252 c.444G>C synonymous_variant 0.8 linezolid
rplC 801255 c.447C>T synonymous_variant 0.79 linezolid
rplC 801267 c.459A>C synonymous_variant 0.79 linezolid
rplC 801270 c.462T>C synonymous_variant 0.79 linezolid
rplC 801273 c.465C>G synonymous_variant 0.81 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.83 linezolid
rplC 801303 c.495G>C synonymous_variant 0.85 linezolid
rplC 801309 c.501C>G synonymous_variant 0.83 linezolid
rplC 801312 c.504G>C synonymous_variant 0.8 linezolid
rplC 801324 c.516T>C synonymous_variant 0.72 linezolid
rplC 801330 c.522G>C synonymous_variant 0.62 linezolid
rplC 801331 c.523_525delGTGinsAC frameshift_variant&missense_variant 0.62 linezolid
rplC 801337 p.Val177Thr missense_variant 0.63 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.62 linezolid
rplC 801348 c.540T>G synonymous_variant 0.6 linezolid
rplC 801357 c.549T>C synonymous_variant 0.62 linezolid
rplC 801385 c.577C>T synonymous_variant 0.41 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.96 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303323 c.393T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303326 c.396C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303329 c.399C>T synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303332 c.402A>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303335 c.405T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303344 p.Phe138Leu missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303362 c.432A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303418 p.Gly163Asp missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303425 c.495G>A synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303497 c.567G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303506 c.576C>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>T synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303557 c.627G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303966 c.1036C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303977 c.1047C>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.62 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303998 c.1068T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304013 c.1083G>A synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304019 c.1089C>T synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1304048 p.Ala373Gly missense_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304106 c.1176G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304118 c.1188C>A synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304133 c.1203G>A synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304577 c.1647C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304607 c.1677C>T synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304610 c.1680C>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>A synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304652 c.1722C>A synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304655 c.1725C>T synonymous_variant 0.82 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304658 c.1728C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304709 c.1779C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.68 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>A synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304751 c.1821C>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304763 c.1833C>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304772 c.1842C>T synonymous_variant 0.77 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304778 c.1848T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304826 c.1896G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.53 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304835 c.1905G>A synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304967 c.2037G>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
sigE 1364622 c.210C>G synonymous_variant 0.24 pyrazinamide
sigE 1364625 c.213A>G synonymous_variant 0.26 pyrazinamide
sigE 1364640 c.228G>T synonymous_variant 0.49 pyrazinamide
sigE 1364647 c.235_237delGCCinsTG frameshift_variant&missense_variant 0.53 pyrazinamide Uncertain significance
sigE 1364652 c.240C>G synonymous_variant 0.56 pyrazinamide
sigE 1364661 c.249C>G synonymous_variant 0.58 pyrazinamide
sigE 1364667 c.255T>C synonymous_variant 0.57 pyrazinamide
sigE 1364676 c.264C>G synonymous_variant 0.59 pyrazinamide
sigE 1364703 c.291G>C synonymous_variant 0.74 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.76 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.78 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.78 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.77 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.8 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.76 pyrazinamide
sigE 1364767 c.355_357delAGGinsCC frameshift_variant&missense_variant 0.71 pyrazinamide Uncertain significance
sigE 1364772 c.360G>C synonymous_variant 0.72 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.71 pyrazinamide
sigE 1364782 c.370_372delGTCinsCG frameshift_variant&missense_variant 0.7 pyrazinamide Uncertain significance
sigE 1364790 c.378T>C synonymous_variant 0.73 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.77 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.75 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.73 pyrazinamide
sigE 1364818 c.406_408delCTAinsTG frameshift_variant&stop_gained 0.74 pyrazinamide Uncertain significance
sigE 1364832 c.420C>G synonymous_variant 0.7 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.71 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.69 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.72 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.74 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.7 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.67 pyrazinamide
sigE 1364886 c.474G>A synonymous_variant 0.67 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.67 pyrazinamide Uncertain significance
sigE 1364892 c.480C>G synonymous_variant 0.7 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.74 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.67 pyrazinamide
sigE 1364920 p.Glu170Ser missense_variant 0.66 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.7 pyrazinamide Uncertain significance
sigE 1364956 c.544C>T synonymous_variant 0.68 pyrazinamide
sigE 1364961 c.549A>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
sigE 1364964 c.552T>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.57 pyrazinamide
sigE 1364980 c.568_570delTTGinsCC frameshift_variant&missense_variant 0.57 pyrazinamide Uncertain significance
sigE 1364984 p.Ala191Asp missense_variant 0.58 pyrazinamide
sigE 1364994 c.582G>C synonymous_variant 0.62 pyrazinamide
sigE 1365000 c.588G>A synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
sigE 1365006 c.594T>C synonymous_variant 0.66 pyrazinamide
sigE 1365015 c.603G>C synonymous_variant 0.66 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.59 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.54 pyrazinamide
sigE 1365063 c.651A>G synonymous_variant 0.37 pyrazinamide
sigE 1365066 c.654G>C synonymous_variant 0.35 pyrazinamide
sigE 1365068 p.Gly219Asp missense_variant 0.36 pyrazinamide Uncertain significance
sigE 1365072 c.660G>C synonymous_variant 0.36 pyrazinamide
sigE 1365078 c.666C>G synonymous_variant 0.36 pyrazinamide
sigE 1365081 c.669G>C synonymous_variant 0.37 pyrazinamide
sigE 1365084 c.672G>C synonymous_variant 0.36 pyrazinamide
sigE 1365087 c.675A>G synonymous_variant 0.36 pyrazinamide
sigE 1365090 c.678T>C synonymous_variant 0.36 pyrazinamide
sigE 1365096 c.684G>C synonymous_variant 0.38 pyrazinamide
sigE 1365099 c.687A>C synonymous_variant 0.38 pyrazinamide
sigE 1365117 c.705A>G synonymous_variant 0.34 pyrazinamide
sigE 1365123 c.711G>C synonymous_variant 0.23 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472279 n.434T>C non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_454delGT non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472303 n.458_470delGGTTCTCTCGGATinsTGAGG non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444T>G non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473290 n.1445_1446insAA non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154C>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473813 n.156C>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171G>C non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630delTinsCCC non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474293 n.637_644delCCTCTCCG non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474418 n.761C>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474421 n.764_767delGCGCinsA non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474437 n.780_781delGAinsTTGGT non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474710 n.1053delTinsACAA non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474720 n.1063C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475017 n.1360G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475379 n.1722G>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475382 n.1725A>C non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475393 n.1737_1738insGATG non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475397 n.1741_1745delCTCAC non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475404 n.1747A>G non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476740 n.3083G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476741 n.3084G>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476743 n.3086A>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476744 n.3087G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476757 n.3100T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
inhA 1673667 c.-535A>G upstream_gene_variant 0.25 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.44 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673682 c.-520G>C upstream_gene_variant 0.44 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673692 c.-510C>G upstream_gene_variant 0.48 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673697 c.-505G>C upstream_gene_variant 0.5 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.45 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.44 ethionamide
isoniazid
inhA 1673724 c.-478A>G upstream_gene_variant 0.45 ethionamide
isoniazid
inhA 1673727 c.-475C>T upstream_gene_variant 0.47 ethionamide
isoniazid Uncertain significance
fabG1 1673733 p.Met98Ile missense_variant 0.44 ethionamide
isoniazid
inhA 1673736 c.-466G>A upstream_gene_variant 0.45 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.42 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.42 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.42 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.48 ethionamide
isoniazid
inhA 1673877 c.-325C>G upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.51 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.53 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.53 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.53 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.54 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.54 ethionamide
isoniazid
inhA 1673946 c.-256C>G upstream_gene_variant 0.57 ethionamide
isoniazid
inhA 1673950 c.-252C>T upstream_gene_variant 0.57 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.56 ethionamide
isoniazid
inhA 1673967 c.-235G>C upstream_gene_variant 0.56 ethionamide
isoniazid
inhA 1673973 c.-229G>C upstream_gene_variant 0.54 ethionamide
isoniazid Uncertain significance
inhA 1673976 c.-226T>C upstream_gene_variant 0.51 ethionamide
isoniazid
inhA 1673979 c.-223G>C upstream_gene_variant 0.51 ethionamide
isoniazid
inhA 1673988 c.-214G>C upstream_gene_variant 0.51 ethionamide
isoniazid
inhA 1674428 p.Gly76Asp missense_variant 0.35 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674433 c.232_234delGTGinsAC frameshift_variant&missense_variant 0.35 ethionamide
isoniazid
inhA 1674443 p.Ala81Val missense_variant 0.54 ethionamide
isoniazid
inhA 1674450 c.249G>C synonymous_variant 0.68 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.71 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674474 c.273G>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674502 c.301_303delACCinsTG frameshift_variant&missense_variant 0.82 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674513 c.312C>G synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674534 c.333G>A synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.78 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.78 ethionamide
isoniazid
inhA 1674561 c.360C>T synonymous_variant 0.76 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.62 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.6 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.55 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.42 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674711 c.510G>C synonymous_variant 0.77 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674737 p.Ala179Val missense_variant 0.8 ethionamide
isoniazid
inhA 1674741 c.540C>A synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674742 p.Lys181Pro missense_variant 0.81 ethionamide
isoniazid
inhA 1674745 p.Tyr182His missense_variant 0.82 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674750 c.549T>G synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674786 c.585G>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.86 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674810 c.609C>G synonymous_variant 0.85 ethionamide
isoniazid
inhA 1674816 c.615T>A synonymous_variant 0.85 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674825 c.624C>T synonymous_variant 0.81 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674828 c.627G>A synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674839 p.Ala213Glu missense_variant 0.8 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.79 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.79 ethionamide
isoniazid Uncertain significance
inhA 1674870 c.669T>C synonymous_variant 0.77 ethionamide
isoniazid
inhA 1674879 c.678T>G synonymous_variant 0.7 ethionamide
isoniazid
inhA 1674882 c.681G>C synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.69 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674892 p.Asn231Asp missense_variant 0.72 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674904 p.Ala235Pro missense_variant 0.63 ethionamide
isoniazid
inhA 1674933 c.732G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674963 c.762G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674966 c.765T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.28 ethionamide
isoniazid
inhA 1674970 c.769_771delATCinsGG frameshift_variant&missense_variant 0.28 ethionamide
isoniazid
rpsA 1833537 c.-5_-1delACAATinsCCAC upstream_gene_variant 0.72 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.8 pyrazinamide
rpsA 1833554 p.Thr5Ser missense_variant 0.81 pyrazinamide
rpsA 1833568 c.27G>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>C synonymous_variant 0.87 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.87 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.88 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.88 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.88 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.89 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.86 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.86 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.85 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.85 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.87 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.86 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.87 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.88 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTA frameshift_variant&missense_variant 0.87 pyrazinamide Uncertain significance
rpsA 1833745 c.204G>C synonymous_variant 0.86 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.88 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.88 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.89 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.89 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.89 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.89 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.9 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.89 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.91 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.92 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.92 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.91 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.88 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.89 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.89 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.89 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.86 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.87 pyrazinamide
rpsA 1834087 c.546C>T synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
rpsA 1834093 c.552G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834094 c.553C>T synonymous_variant 0.82 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.84 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.74 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.85 pyrazinamide
rpsA 1834282 c.741C>T synonymous_variant 0.88 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.9 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.89 pyrazinamide
rpsA 1834309 c.768C>T synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
rpsA 1834348 c.807T>C synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>A synonymous_variant 0.86 pyrazinamide
rpsA 1834357 c.816T>G synonymous_variant 0.86 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.85 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.85 pyrazinamide
rpsA 1834390 c.849G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.87 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.87 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.86 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.87 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.87 pyrazinamide
rpsA 1834556 p.Ala339Gln missense_variant 0.87 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.91 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834627 c.1086C>G synonymous_variant 0.92 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.9 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.89 pyrazinamide
rpsA 1834649 p.Thr370Leu missense_variant 0.88 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.88 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.88 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.83 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.85 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.82 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.82 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.78 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.77 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.77 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.77 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834811 c.1270C>A synonymous_variant 0.77 pyrazinamide
rpsA 1834849 c.1308C>G synonymous_variant 0.47 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.88 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.88 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.85 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.85 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.84 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.84 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.83 linezolid
tsnR 1853443 c.-163G>C upstream_gene_variant 0.83 linezolid
tsnR 1853456 c.-150C>T upstream_gene_variant 0.79 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.78 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.77 linezolid
tsnR 1853474 c.-132C>G upstream_gene_variant 0.76 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.73 linezolid
tsnR 1853480 c.-126G>C upstream_gene_variant 0.72 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.72 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.67 linezolid
tsnR 1853498 c.-108G>C upstream_gene_variant 0.66 linezolid
tsnR 1853513 c.-93C>G upstream_gene_variant 0.57 linezolid
tsnR 1853516 c.-90C>G upstream_gene_variant 0.57 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064981 c.-253G>C upstream_gene_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064987 c.-259G>C upstream_gene_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
bacA 2065002 c.-274C>G upstream_gene_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
bacA 2065008 c.-280C>G upstream_gene_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
ndh 2103226 c.-184C>G upstream_gene_variant 0.94 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155650 c.462G>A synonymous_variant 0.3 isoniazid Not assoc w R - Interim
katG 2155655 p.Lys153Gln missense_variant 0.35 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.49 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.68 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.69 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.7 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.63 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.64 isoniazid
katG 2155728 c.384G>T synonymous_variant 0.62 isoniazid
katG 2155733 c.376_378delATG conservative_inframe_deletion 0.63 isoniazid
katG 2155738 p.Gly125Ala missense_variant 0.64 isoniazid Uncertain significance
katG 2155744 c.365_368delCCGGinsGTGGTCA missense_variant&conservative_inframe_insertion 0.67 isoniazid
katG 2155782 c.330C>G synonymous_variant 0.49 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.42 isoniazid
katG 2156287 c.-176T>C upstream_gene_variant 0.35 isoniazid
katG 2156296 c.-185T>C upstream_gene_variant 0.38 isoniazid Uncertain significance
katG 2156299 c.-188G>C upstream_gene_variant 0.4 isoniazid
katG 2156305 c.-194T>C upstream_gene_variant 0.43 isoniazid
katG 2156314 c.-203C>G upstream_gene_variant 0.42 isoniazid
katG 2156323 c.-212T>C upstream_gene_variant 0.41 isoniazid Uncertain significance
katG 2156343 c.-232A>C upstream_gene_variant 0.47 isoniazid
katG 2156344 c.-233C>G upstream_gene_variant 0.41 isoniazid Uncertain significance
katG 2156350 c.-239C>T upstream_gene_variant 0.44 isoniazid
katG 2156353 c.-242C>T upstream_gene_variant 0.44 isoniazid Uncertain significance
katG 2156362 c.-251C>T upstream_gene_variant 0.43 isoniazid
katG 2156368 c.-257G>C upstream_gene_variant 0.43 isoniazid
katG 2156374 c.-263A>G upstream_gene_variant 0.39 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.88 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.83 isoniazid
kasA 2517968 c.-147T>G upstream_gene_variant 0.79 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.75 isoniazid
kasA 2517980 c.-135C>T upstream_gene_variant 0.76 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.77 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.45 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.35 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.27 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.37 isoniazid
kasA 2518171 c.57C>A synonymous_variant 0.32 isoniazid
kasA 2518172 c.58_60delACAinsGG frameshift_variant&missense_variant 0.32 isoniazid
kasA 2518180 c.66G>T synonymous_variant 0.32 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.35 isoniazid
kasA 2518193 p.Pro27Ala missense_variant 0.35 isoniazid
kasA 2518198 c.84C>T synonymous_variant 0.36 isoniazid
kasA 2518210 c.96G>T synonymous_variant 0.37 isoniazid
kasA 2518219 c.105T>C synonymous_variant 0.38 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.37 isoniazid
kasA 2518228 c.114C>A synonymous_variant 0.39 isoniazid
kasA 2518240 c.126C>A synonymous_variant 0.4 isoniazid
kasA 2518555 c.441C>G synonymous_variant 0.6 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.6 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.6 isoniazid
kasA 2518573 c.459G>C synonymous_variant 0.61 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.61 isoniazid
kasA 2518579 c.465T>G synonymous_variant 0.63 isoniazid
kasA 2518582 c.468G>T synonymous_variant 0.64 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.67 isoniazid
kasA 2518591 c.477G>A synonymous_variant 0.68 isoniazid
kasA 2518600 c.486C>A synonymous_variant 0.67 isoniazid
kasA 2518603 c.489G>C synonymous_variant 0.67 isoniazid
kasA 2518607 c.493_495delATGinsCC frameshift_variant&missense_variant 0.66 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.77 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.81 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.8 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.78 isoniazid
kasA 2518688 p.Val192Ile missense_variant 0.76 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.76 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.76 isoniazid
kasA 2518702 c.588C>A synonymous_variant 0.76 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.76 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.75 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.73 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.72 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.74 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.61 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.53 isoniazid
kasA 2518769 p.Arg219Asn missense_variant 0.23 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.26 isoniazid
kasA 2519143 c.1029G>C synonymous_variant 0.26 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.27 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.28 isoniazid
kasA 2519185 c.1071C>G synonymous_variant 0.29 isoniazid
kasA 2519194 c.1080G>C synonymous_variant 0.29 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.54 isoniazid
kasA 2519227 c.1113G>C synonymous_variant 0.54 isoniazid
kasA 2519233 c.1119C>T synonymous_variant 0.52 isoniazid
kasA 2519236 c.1122G>A synonymous_variant 0.53 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.55 isoniazid
kasA 2519242 c.1128C>G synonymous_variant 0.55 isoniazid
kasA 2519245 c.1131T>C synonymous_variant 0.55 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.52 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 0.52 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.52 isoniazid
kasA 2519269 c.1155C>T synonymous_variant 0.55 isoniazid
kasA 2519272 c.1158C>G synonymous_variant 0.54 isoniazid
kasA 2519278 c.1164A>G synonymous_variant 0.51 isoniazid
kasA 2519281 c.1167G>T synonymous_variant 0.51 isoniazid
kasA 2519284 c.1170C>A synonymous_variant 0.52 isoniazid
kasA 2519293 c.1179T>C synonymous_variant 0.49 isoniazid
kasA 2519298 p.Arg395Gln missense_variant 0.49 isoniazid
kasA 2519305 c.1191A>C synonymous_variant 0.47 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.47 isoniazid
ahpC 2726633 c.441C>G synonymous_variant 0.64 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.64 isoniazid
ahpC 2726642 c.450C>G synonymous_variant 0.61 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.6 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.61 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.62 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.64 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.64 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.65 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.64 isoniazid
ahpC 2726717 c.525A>C synonymous_variant 0.68 isoniazid
folC 2746654 c.945C>G synonymous_variant 0.24 para-aminosalicylic_acid
folC 2746663 c.936T>C synonymous_variant 0.38 para-aminosalicylic_acid
folC 2746666 c.933C>G synonymous_variant 0.44 para-aminosalicylic_acid
folC 2746677 p.Ser308Ala missense_variant 0.45 para-aminosalicylic_acid
folC 2746678 c.921T>C synonymous_variant 0.45 para-aminosalicylic_acid
folC 2746681 c.918C>T synonymous_variant 0.46 para-aminosalicylic_acid
folC 2746689 p.Leu304Val missense_variant 0.47 para-aminosalicylic_acid
folC 2746702 c.897G>C synonymous_variant 0.47 para-aminosalicylic_acid
folC 2746705 c.894G>A synonymous_variant 0.5 para-aminosalicylic_acid
folC 2746708 c.891C>T synonymous_variant 0.5 para-aminosalicylic_acid
folC 2746728 c.871T>C synonymous_variant 0.49 para-aminosalicylic_acid
folC 2746738 c.861C>G synonymous_variant 0.47 para-aminosalicylic_acid
folC 2746744 c.855T>G synonymous_variant 0.46 para-aminosalicylic_acid
folC 2746747 c.852G>C synonymous_variant 0.47 para-aminosalicylic_acid
folC 2746767 p.Gln278Glu missense_variant 0.38 para-aminosalicylic_acid
folC 2746771 c.826_828delGTAinsCG frameshift_variant&missense_variant 0.33 para-aminosalicylic_acid
Rv2477c 2782444 c.1599G>A synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782454 p.Gly530Ala missense_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782465 c.1578G>A synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.71 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782504 c.1539G>A synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.84 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.84 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783025 c.1018C>T synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783038 c.1003_1005delGCCinsCG frameshift_variant&synonymous_variant 0.67 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.77 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>C synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.82 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.84 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.901_903delACCinsTA frameshift_variant&missense_variant 0.85 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783149 c.894G>C synonymous_variant 0.85 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783155 c.888C>G synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.86 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>T synonymous_variant 0.84 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783218 c.825C>G synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>A synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.63 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783239 c.804G>A synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Lys missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783245 c.796_798delTTGinsCC frameshift_variant&missense_variant 0.48 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783254 c.789A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.67 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783488 c.555G>A synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.48 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.65 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783599 c.444G>T synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.58 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783629 c.414C>T synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>A synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783650 p.His131Ala missense_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783689 c.354G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783791 c.252C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783836 c.207C>T synonymous_variant 0.66 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783872 c.171G>C synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 p.Lys56Thr missense_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>G synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783944 c.99G>A synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783947 c.96C>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783957 p.Tyr29Leu missense_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 p.Ser27Asn missense_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783968 p.Thr25Ser missense_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>T synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783986 c.57G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.61 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
pepQ 2859739 p.Ala227Ser missense_variant 0.45 clofazimine
bedaquiline
pepQ 2859747 c.672C>G synonymous_variant 0.45 clofazimine
bedaquiline
pepQ 2859750 c.669C>T synonymous_variant 0.47 clofazimine
bedaquiline
pepQ 2859765 c.654G>C synonymous_variant 0.5 clofazimine
bedaquiline
pepQ 2859771 c.648T>C synonymous_variant 0.53 clofazimine
bedaquiline
pepQ 2859778 p.Val214Ala missense_variant 0.5 clofazimine
bedaquiline
pepQ 2859780 p.Gln213Ala missense_variant 0.5 clofazimine
bedaquiline
pepQ 2859807 c.612C>T synonymous_variant 0.56 clofazimine
bedaquiline
pepQ 2859819 c.600G>C synonymous_variant 0.55 clofazimine
bedaquiline
pepQ 2859822 c.597T>C synonymous_variant 0.53 clofazimine
bedaquiline
pepQ 2859834 c.585T>G synonymous_variant 0.47 clofazimine
bedaquiline
Rv2680 2996381 p.Ser93Ala missense_variant 0.33 capreomycin
Rv2680 2996386 c.282T>C synonymous_variant 0.32 capreomycin Not assoc w R - Interim
Rv2681 2996401 c.-338T>G upstream_gene_variant 0.35 capreomycin
Rv2680 2996404 p.Ile100Met missense_variant 0.35 capreomycin
Rv2681 2996407 c.-332C>G upstream_gene_variant 0.37 capreomycin
Rv2681 2996419 c.-320T>C upstream_gene_variant 0.36 capreomycin
Rv2680 2996420 p.Val106Ile missense_variant 0.36 capreomycin
Rv2681 2996440 c.-299G>C upstream_gene_variant 0.35 capreomycin
Rv2681 2996443 c.-296T>C upstream_gene_variant 0.33 capreomycin
Rv2680 2996446 c.342A>G synonymous_variant 0.33 capreomycin Not assoc w R - Interim
Rv2681 2996449 c.-290C>G upstream_gene_variant 0.35 capreomycin
Rv2681 2996452 c.-287C>G upstream_gene_variant 0.36 capreomycin
Rv2681 2996458 c.-281C>G upstream_gene_variant 0.36 capreomycin
Rv2752c 3065169 c.1023C>T synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065186 c.1006T>C synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065187 c.1003_1005delGTGinsAC frameshift_variant&missense_variant 0.35 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065193 c.999C>G synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065199 c.993T>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065202 c.990T>G synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065205 c.987T>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065210 c.982T>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065223 c.969T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065226 c.966G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065229 c.963G>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065241 c.951A>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065249 c.943T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065517 c.675C>G synonymous_variant 0.5 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065529 c.663G>A synonymous_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065532 c.660A>G synonymous_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065538 c.654G>C synonymous_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065541 c.651A>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065547 c.645A>G synonymous_variant 0.51 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065553 c.639A>G synonymous_variant 0.51 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065559 c.633C>G synonymous_variant 0.54 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065562 c.630T>G synonymous_variant 0.54 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065576 p.Ala206Ser missense_variant 0.65 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065592 c.600G>C synonymous_variant 0.73 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065595 p.Leu199Phe missense_variant 0.73 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065607 c.585C>G synonymous_variant 0.72 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065612 p.Thr194Ala missense_variant 0.73 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065613 c.579C>T synonymous_variant 0.73 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065639 c.553C>T synonymous_variant 0.58 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065640 c.552T>C synonymous_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065643 c.549C>G synonymous_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065646 c.546C>G synonymous_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065649 p.Arg181Gln missense_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065653 p.Gly180Asp missense_variant 0.6 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065659 p.Pro178Leu missense_variant 0.57 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065661 c.531A>G synonymous_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065666 c.526T>C synonymous_variant 0.57 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065675 p.Phe173Leu missense_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065697 c.493_495delATCinsGG frameshift_variant&missense_variant 0.4 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065703 c.489A>C synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066769 c.-579_-578delAAinsCG upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066786 c.-595C>G upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066794 c.-603C>T upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066804 c.-613G>A upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066816 c.-625G>C upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066828 c.-637C>G upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066836 c.-645C>A upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066840 c.-649C>T upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066864 c.-674_-673delCCinsTG upstream_gene_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066876 c.-687_-685delGTTinsAC upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066879 c.-688T>G upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067309 p.Ile213Val missense_variant 0.58 para-aminosalicylic_acid
thyX 3067313 c.633G>C synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067319 c.627G>C synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067322 c.624C>T synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.73 para-aminosalicylic_acid
thyX 3067354 p.Met198Val missense_variant 0.72 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.71 para-aminosalicylic_acid
thyX 3067364 c.582C>T synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067382 c.564C>T synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067385 c.561C>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.68 para-aminosalicylic_acid
thyX 3067403 c.543C>A synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067418 c.528C>G synonymous_variant 0.61 para-aminosalicylic_acid
thyX 3067433 c.513C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067436 c.510C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.45 para-aminosalicylic_acid
thyX 3067578 p.Glu123Ala missense_variant 0.41 para-aminosalicylic_acid
thyX 3067586 c.360C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067592 c.354G>C synonymous_variant 0.51 para-aminosalicylic_acid
thyX 3067595 c.351C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067598 c.348C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067602 p.Arg115Gln missense_variant 0.47 para-aminosalicylic_acid
thyX 3067610 c.334_336delAAGinsCC frameshift_variant&missense_variant 0.46 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.45 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067640 c.306G>A synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.71 para-aminosalicylic_acid
thyX 3067655 c.291G>C synonymous_variant 0.72 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.72 para-aminosalicylic_acid
thyX 3067665 p.Ile94Thr missense_variant 0.74 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.77 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.77 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.78 para-aminosalicylic_acid
thyX 3067715 c.229_231delAGCinsTCG synonymous_variant 0.77 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.84 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.85 para-aminosalicylic_acid
thyX 3067763 c.181_183delCTCinsGG frameshift_variant&missense_variant 0.83 para-aminosalicylic_acid
thyX 3067770 p.Gly59Ala missense_variant 0.83 para-aminosalicylic_acid
thyX 3067787 p.Lys53Arg missense_variant 0.81 para-aminosalicylic_acid
thyX 3067790 c.156C>G synonymous_variant 0.82 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.84 para-aminosalicylic_acid
thyX 3067826 c.120C>T synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067838 c.108C>G synonymous_variant 0.81 para-aminosalicylic_acid
thyX 3067847 c.99C>G synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067850 c.96A>G synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067856 p.Asp30Glu missense_variant 0.79 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.75 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.73 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.71 para-aminosalicylic_acid
thyX 3067894 c.52T>C synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.68 para-aminosalicylic_acid
thyX 3067901 c.45C>G synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067925 c.21G>A synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067933 p.Ala5Thr missense_variant 0.46 para-aminosalicylic_acid
thyX 3067945 c.-1delC upstream_gene_variant 0.3 para-aminosalicylic_acid
thyA 3073818 c.654G>A synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3073821 c.651G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3073836 c.636C>T synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.63 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.75 para-aminosalicylic_acid
thyA 3073884 c.588C>G synonymous_variant 0.71 para-aminosalicylic_acid
thyA 3073888 p.Ser195Glu missense_variant 0.72 para-aminosalicylic_acid
thyA 3073890 c.580_582delTTGinsCC frameshift_variant&missense_variant 0.69 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.71 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.76 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.76 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.81 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.81 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.79 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.79 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.82 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3074000 c.472C>A synonymous_variant 0.84 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.84 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.78 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.77 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.77 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.76 para-aminosalicylic_acid
thyA 3074055 p.Glu139Ala missense_variant 0.74 para-aminosalicylic_acid
thyA 3074061 c.409_411delGAAinsCG frameshift_variant&missense_variant 0.75 para-aminosalicylic_acid
thyA 3074070 c.402C>T synonymous_variant 0.75 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.72 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.73 para-aminosalicylic_acid
thyA 3074094 c.378G>T synonymous_variant 0.63 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.63 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3074112 c.360C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyA 3074115 c.357G>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074121 c.351T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.61 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAC frameshift_variant&missense_variant 0.61 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.61 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3074184 c.288A>C synonymous_variant 0.56 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyA 3074193 c.277_279delATCinsGG frameshift_variant&missense_variant 0.61 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.63 para-aminosalicylic_acid
thyA 3074208 c.264C>T synonymous_variant 0.63 para-aminosalicylic_acid
thyA 3074214 p.Asp86Glu missense_variant 0.64 para-aminosalicylic_acid
thyA 3074244 c.228A>C synonymous_variant 0.6 para-aminosalicylic_acid
ald 3086739 c.-81G>A upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.95 pyrazinamide Not assoc w R - Interim
lpqB 3624637 p.His92Asn missense_variant 0.33 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 0.4 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624665 c.246C>T synonymous_variant 0.56 bedaquiline
rifampicin
lpqB 3624671 p.Ala80Gly missense_variant 0.57 bedaquiline
rifampicin
lpqB 3624675 p.Asn79Arg missense_variant 0.57 bedaquiline
rifampicin
lpqB 3624677 c.234C>G synonymous_variant 0.6 bedaquiline
rifampicin
lpqB 3624683 c.228G>C synonymous_variant 0.65 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.64 bedaquiline
rifampicin
lpqB 3624704 c.207G>T synonymous_variant 0.66 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.69 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.75 bedaquiline
rifampicin
lpqB 3624725 c.186G>C synonymous_variant 0.78 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.78 bedaquiline
rifampicin
lpqB 3624734 c.177A>C synonymous_variant 0.78 bedaquiline
rifampicin
lpqB 3624755 c.156A>G synonymous_variant 0.77 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624761 c.150G>C synonymous_variant 0.74 bedaquiline
rifampicin
lpqB 3624776 c.133_135delGGTinsAC frameshift_variant&missense_variant 0.7 bedaquiline
rifampicin Uncertain significance
lpqB 3624783 p.Ser43Thr missense_variant 0.67 bedaquiline
rifampicin
lpqB 3624785 c.126G>C synonymous_variant 0.66 bedaquiline
rifampicin
lpqB 3624797 p.Asn38Ser missense_variant 0.6 bedaquiline
rifampicin
lpqB 3624802 p.Ser37Pro missense_variant 0.6 bedaquiline
rifampicin
lpqB 3624807 p.Val35Ala missense_variant 0.58 bedaquiline
rifampicin
lpqB 3624809 c.102G>C synonymous_variant 0.57 bedaquiline
rifampicin
lpqB 3624812 c.99T>G synonymous_variant 0.57 bedaquiline
rifampicin
lpqB 3624815 p.Glu32Asp missense_variant 0.56 bedaquiline
rifampicin
lpqB 3624833 c.78A>G synonymous_variant 0.45 bedaquiline
rifampicin
lpqB 3625045 c.-135C>G upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625054 c.-144C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625057 c.-147C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625072 c.-162G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625075 c.-165G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625084 c.-174C>T upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3625095 p.Glu507Lys missense_variant 0.4 bedaquiline
rifampicin
lpqB 3625102 c.-192A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
lpqB 3625111 c.-201G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625114 c.-204G>A upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.61 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.68 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625141 c.-231T>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.73 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.71 bedaquiline
rifampicin
lpqB 3625162 c.-252T>G upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625165 c.-255G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
lpqB 3625168 c.-258G>T upstream_gene_variant 0.71 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 0.66 bedaquiline
rifampicin
lpqB 3625186 c.-276T>A upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.68 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.69 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.69 bedaquiline
rifampicin
lpqB 3625204 c.-294G>C upstream_gene_variant 0.68 bedaquiline
rifampicin
lpqB 3625207 c.-297C>G upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>G upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625246 c.-336G>C upstream_gene_variant 0.59 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625262 p.Tyr451Phe missense_variant 0.36 bedaquiline
rifampicin
mtrB 3625264 c.1350C>T synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625267 c.1347T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625273 c.-363C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625282 c.-372C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Lys missense_variant 0.38 bedaquiline
rifampicin
lpqB 3625315 c.-405G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625318 c.-408G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3625321 c.1293A>G synonymous_variant 0.4 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625327 c.-417A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625342 c.1272C>G synonymous_variant 0.42 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625345 c.-435T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625519 c.-609G>A upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625531 c.-621C>G upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625540 c.-630G>C upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625546 c.-636C>T upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.7 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625570 c.-660G>C upstream_gene_variant 0.7 bedaquiline
rifampicin
lpqB 3625579 c.-669A>C upstream_gene_variant 0.72 bedaquiline
rifampicin
lpqB 3625587 c.-677C>T upstream_gene_variant 0.72 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.75 bedaquiline
rifampicin
lpqB 3625603 c.-693G>A upstream_gene_variant 0.77 bedaquiline
rifampicin
mtrB 3625607 p.Thr336Ile missense_variant 0.75 bedaquiline
rifampicin Uncertain significance
lpqB 3625609 c.-699C>G upstream_gene_variant 0.75 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.77 bedaquiline
rifampicin
mtrB 3625620 c.994C>T synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625623 p.Thr331Ser missense_variant 0.8 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrB 3625637 p.Ala326Asp missense_variant 0.81 bedaquiline
rifampicin
mtrB 3625650 p.Tyr322His missense_variant 0.84 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.83 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.82 bedaquiline
rifampicin
lpqB 3625678 c.-768C>G upstream_gene_variant 0.83 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.83 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.83 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.85 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.89 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.91 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625798 c.-888G>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3625845 p.Ser257Thr missense_variant 0.75 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625879 c.-969G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626029 c.585A>G synonymous_variant 0.59 bedaquiline
rifampicin
mtrB 3626035 c.579G>C synonymous_variant 0.62 bedaquiline
rifampicin
mtrB 3626048 p.Arg189Pro missense_variant 0.73 bedaquiline
rifampicin
mtrB 3626054 p.Leu187Ser missense_variant 0.75 bedaquiline
rifampicin
mtrB 3626062 c.552T>C synonymous_variant 0.73 bedaquiline
rifampicin
mtrB 3626065 c.549G>C synonymous_variant 0.74 bedaquiline
rifampicin
mtrB 3626077 c.537C>G synonymous_variant 0.74 bedaquiline
rifampicin
mtrB 3626080 c.534G>C synonymous_variant 0.75 bedaquiline
rifampicin
mtrB 3626092 p.Gly174Ala missense_variant 0.75 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626095 p.Glu173Asp missense_variant 0.74 bedaquiline
rifampicin
mtrB 3626101 c.511_513delCAGinsGC frameshift_variant&missense_variant 0.75 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626123 p.Ala164Ser missense_variant 0.74 bedaquiline
rifampicin
mtrB 3626126 p.Ala163Val missense_variant 0.73 bedaquiline
rifampicin
mtrB 3626131 c.483G>T synonymous_variant 0.76 bedaquiline
rifampicin
mtrB 3626146 p.Gly156Glu missense_variant 0.63 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 0.97 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626669 c.-56T>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrA 3626711 p.Thr213Gln missense_variant 0.62 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrB 3626744 c.-131G>C upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 0.69 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>G upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3626756 c.-143C>T upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626776 c.-163A>C upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.74 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.72 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626822 c.-209T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrA 3626825 c.525T>A synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626924 c.-311G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626933 c.-320C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.35 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3626949 p.Ala134Gly missense_variant 0.4 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.64 bedaquiline
rifampicin Uncertain significance
mtrB 3626999 c.-386G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrB 3627011 c.-398T>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrB 3627014 c.-401G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrA 3627020 c.330G>A synonymous_variant 0.75 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 0.79 bedaquiline
rifampicin
mtrB 3627059 c.-446G>A upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.82 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.81 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3627092 c.-479C>G upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 0.78 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.78 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627125 c.-512C>G upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3627131 c.-518C>G upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3627143 c.-530G>T upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627173 c.-560G>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrA 3627185 c.163_165delTTGinsCC frameshift_variant&missense_variant 0.6 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627203 c.-590C>G upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3627206 c.-593G>A upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627212 c.-599C>T upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627215 c.-602G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627224 c.-611G>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627233 c.-620T>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627263 c.-650C>T upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrA 3627269 c.81G>A synonymous_variant 0.55 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3627272 c.-659G>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627296 c.-683T>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCC frameshift_variant&missense_variant 0.47 bedaquiline
rifampicin
mtrA 3627305 c.43_45delGCTinsCG frameshift_variant&synonymous_variant 0.48 bedaquiline
rifampicin
mtrB 3627308 c.-695C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627320 c.-707C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627325 c.-712T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
fbiB 3641888 c.354A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3641906 c.372T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiB 3641909 c.375T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiB 3641914 p.Ala127Gly missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3641918 c.384T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3641921 c.387C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3641924 c.390A>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3641935 p.Ala134Asp missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiB 3641948 p.Glu138Asp missense_variant 0.47 clofazimine
pretomanid
delamanid
fbiB 3641968 p.Ala145Gly missense_variant 0.47 clofazimine
pretomanid
delamanid
fbiB 3641972 c.438G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiB 3641975 c.441C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiB 3641993 c.459A>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiB 3641999 c.465C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
rpoA 3877587 c.921A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.75 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.83 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.82 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.82 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.85 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.83 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877794 c.714G>T synonymous_variant 0.82 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.88 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.88 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>C synonymous_variant 0.91 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.88 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.74 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.73 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3878001 c.505_507delTCAinsAGC synonymous_variant 0.67 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.71 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.69 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.65 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.65 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.63 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.64 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.65 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.65 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.68 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.7 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.73 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.75 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.74 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.73 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.77 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.78 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.79 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.81 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.88 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.89 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.93 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.91 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.91 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.91 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.9 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.89 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>C synonymous_variant 0.83 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.75 rifampicin
rpoA 3878358 c.150C>A synonymous_variant 0.6 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.58 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.54 rifampicin
rpoA 3878388 c.120C>A synonymous_variant 0.48 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.56 rifampicin
rpoA 3878406 c.102G>C synonymous_variant 0.54 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.44 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.42 rifampicin
rpoA 3878432 c.76C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878436 c.72A>G synonymous_variant 0.33 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.32 rifampicin
rpoA 3878449 p.Gln20Arg missense_variant 0.32 rifampicin
rpoA 3878451 c.57C>G synonymous_variant 0.32 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.32 rifampicin
rpoA 3878460 p.Asp16Glu missense_variant 0.32 rifampicin
rpoA 3878465 p.Thr15Ala missense_variant 0.33 rifampicin
rpoA 3878468 p.Leu14Ile missense_variant 0.32 rifampicin
rpoA 3878469 c.39C>A synonymous_variant 0.32 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.34 rifampicin
rpoA 3878475 c.33G>A synonymous_variant 0.38 rifampicin
rpoA 3878483 c.25C>T synonymous_variant 0.39 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.39 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.39 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.4 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.55 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.65 rifampicin Uncertain significance
rpoA 3878886 c.-379G>A upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.67 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.67 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.68 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.68 rifampicin
rpoA 3878908 c.-403_-401delAACinsCTG upstream_gene_variant 0.68 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.67 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.65 rifampicin
rpoA 3878942 c.-436_-435delATinsCA upstream_gene_variant 0.65 rifampicin
rpoA 3878944 c.-437G>T upstream_gene_variant 0.66 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3879049 c.-542A>G upstream_gene_variant 0.48 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.67 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.67 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.68 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.66 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.66 rifampicin
rpoA 3879124 c.-618_-617delTGinsGC upstream_gene_variant 0.66 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.65 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.66 rifampicin
rpoA 3879144 c.-637A>G upstream_gene_variant 0.65 rifampicin
rpoA 3879150 c.-643G>T upstream_gene_variant 0.67 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.69 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.65 rifampicin
ddn 3986615 c.-229C>T upstream_gene_variant 0.82 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.78 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.78 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.73 delamanid
pretomanid
ddn 3986667 c.-177_-175delCTCinsACG upstream_gene_variant 0.7 delamanid
pretomanid
ddn 3986687 c.-157C>T upstream_gene_variant 0.7 delamanid
pretomanid
ddn 3986690 c.-154C>G upstream_gene_variant 0.67 delamanid
pretomanid
ddn 3986696 c.-148G>C upstream_gene_variant 0.62 delamanid
pretomanid
ddn 3986699 c.-145C>G upstream_gene_variant 0.6 delamanid
pretomanid
ddn 3986714 c.-130C>G upstream_gene_variant 0.47 delamanid
pretomanid
clpC1 4038335 c.2370C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038383 c.2322G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038392 c.2313C>G synonymous_variant 0.56 pyrazinamide
clpC1 4038398 c.2307G>C synonymous_variant 0.63 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.62 pyrazinamide
clpC1 4038416 c.2289C>G synonymous_variant 0.56 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038428 c.2277G>T synonymous_variant 0.55 pyrazinamide
clpC1 4038435 p.Ala757Gln missense_variant 0.57 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.5 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038449 c.2256C>G synonymous_variant 0.52 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.55 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038485 p.Gly740Glu missense_variant 0.67 pyrazinamide
clpC1 4038497 c.2206_2208delAGCinsGA frameshift_variant&missense_variant 0.69 pyrazinamide
clpC1 4038521 c.2182_2184delATCinsGG frameshift_variant&missense_variant 0.74 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.76 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.76 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.84 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.81 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.8 pyrazinamide
clpC1 4038605 c.2100G>A synonymous_variant 0.77 pyrazinamide
clpC1 4038613 p.Asn698His missense_variant 0.76 pyrazinamide
clpC1 4038614 c.2091C>T synonymous_variant 0.77 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.79 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.78 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.78 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.75 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.75 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.76 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.75 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4038692 p.Ser671Lys missense_variant 0.7 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.72 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.72 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.74 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.78 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.81 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.82 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.88 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.91 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.91 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.89 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.87 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.87 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.87 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.87 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.87 pyrazinamide
clpC1 4038974 c.1731T>G synonymous_variant 0.86 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.89 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.88 pyrazinamide
clpC1 4039031 c.1674T>G synonymous_variant 0.87 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.86 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.85 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4039082 c.1623C>T synonymous_variant 0.84 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.84 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.84 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.84 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.85 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.86 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039235 c.1470C>T synonymous_variant 0.88 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039244 c.1461G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.89 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.89 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.87 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.9 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>T synonymous_variant 0.87 pyrazinamide
clpC1 4039331 c.1374C>T synonymous_variant 0.84 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.82 pyrazinamide
clpC1 4039347 p.Arg453Gln missense_variant 0.83 pyrazinamide Uncertain significance
clpC1 4039349 c.1356C>T synonymous_variant 0.82 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.84 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.84 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.84 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.87 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.86 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.83 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.8 pyrazinamide
clpC1 4039439 c.1266C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.79 pyrazinamide
clpC1 4039445 c.1260C>T synonymous_variant 0.78 pyrazinamide
clpC1 4039448 c.1257A>T synonymous_variant 0.79 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.76 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039553 c.1152C>A synonymous_variant 0.58 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039570 p.Met379Val missense_variant 0.53 pyrazinamide
clpC1 4039571 c.1134G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.52 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039594 c.1111C>A synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4039601 c.1104G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039607 c.1098C>T synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.81 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.83 pyrazinamide
clpC1 4039646 c.1059G>A synonymous_variant 0.83 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.78 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.8 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.8 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.82 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.82 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4039808 c.897G>A synonymous_variant 0.81 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.82 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.82 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.87 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.88 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.89 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.89 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.88 pyrazinamide
clpC1 4040015 c.690G>A synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040018 c.687G>C synonymous_variant 0.84 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.85 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.85 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.8 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.87 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.87 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.86 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.87 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.86 pyrazinamide
clpC1 4040180 c.525C>T synonymous_variant 0.88 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.84 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.84 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.85 pyrazinamide
clpC1 4040210 c.495G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040213 c.492T>A synonymous_variant 0.85 pyrazinamide
clpC1 4040228 c.477G>A synonymous_variant 0.88 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.9 pyrazinamide
clpC1 4040243 c.462C>T synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4040249 c.456A>G synonymous_variant 0.87 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.87 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>A synonymous_variant 0.83 pyrazinamide
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.8 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.81 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.81 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.78 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.78 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.73 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.71 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.69 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.65 pyrazinamide
clpC1 4040369 c.334_336delCTCinsTG frameshift_variant&synonymous_variant 0.61 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.61 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.6 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.61 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.59 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.66 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.74 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.75 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.78 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.8 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.83 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.86 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.79 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.76 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040552 c.153G>A synonymous_variant 0.73 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.67 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.65 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.59 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.56 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.55 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.55 pyrazinamide
clpC1 4040594 c.111G>T synonymous_variant 0.57 pyrazinamide
clpC1 4040597 c.108C>A synonymous_variant 0.55 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.55 pyrazinamide
clpC1 4040603 c.102T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040606 c.99T>C synonymous_variant 0.59 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.49 pyrazinamide
panD 4044096 c.186C>T synonymous_variant 0.47 pyrazinamide
panD 4044114 c.168C>G synonymous_variant 0.52 pyrazinamide
panD 4044119 c.163C>T synonymous_variant 0.5 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.5 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.5 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
panD 4044147 c.135C>G synonymous_variant 0.45 pyrazinamide
panD 4044150 c.132A>C synonymous_variant 0.45 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
panD 4044159 c.123C>T synonymous_variant 0.45 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.47 pyrazinamide
panD 4044174 c.108C>G synonymous_variant 0.45 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.39 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.39 pyrazinamide
panD 4044611 c.-330C>T upstream_gene_variant 0.42 pyrazinamide
panD 4044638 c.-357C>T upstream_gene_variant 0.64 pyrazinamide
panD 4044643 c.-362G>A upstream_gene_variant 0.61 pyrazinamide
panD 4044644 c.-363A>G upstream_gene_variant 0.62 pyrazinamide
panD 4044647 c.-366C>G upstream_gene_variant 0.64 pyrazinamide
panD 4044654 c.-373C>T upstream_gene_variant 0.62 pyrazinamide
panD 4044659 c.-378G>C upstream_gene_variant 0.62 pyrazinamide
panD 4044662 c.-381C>T upstream_gene_variant 0.62 pyrazinamide
panD 4044668 c.-389_-387delGTGinsAC upstream_gene_variant 0.61 pyrazinamide
panD 4044672 c.-391C>G upstream_gene_variant 0.62 pyrazinamide
panD 4044678 c.-397A>C upstream_gene_variant 0.61 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.58 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.61 pyrazinamide
panD 4044706 c.-425C>A upstream_gene_variant 0.59 pyrazinamide
panD 4044713 c.-432G>C upstream_gene_variant 0.6 pyrazinamide
panD 4044716 c.-435G>C upstream_gene_variant 0.59 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.41 pyrazinamide
glpK 4138514 c.1242A>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138532 c.1224G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138541 c.1215C>T synonymous_variant 0.64 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138595 p.Phe387Tyr missense_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.69 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138646 c.1110G>A synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139312 c.444T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139321 c.435T>G synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139324 c.432A>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139327 c.429G>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139336 c.420C>T synonymous_variant 0.71 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139356 p.Leu134Val missense_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139359 p.Asn133Asp missense_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139360 c.396A>T synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139363 c.393T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139366 c.390T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139372 c.384A>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139375 p.Asp127Glu missense_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139380 c.376C>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139381 c.375G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139387 c.369G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139399 c.357C>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139408 c.348T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139417 c.339A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139420 c.336T>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139570 c.186G>A synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139588 c.168G>C synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Lys missense_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139603 c.153C>G synonymous_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139630 c.126C>T synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139637 p.Ala40Gly missense_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139639 c.115_117delGTGinsAC frameshift_variant&missense_variant 0.79 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139646 c.109_110insGCG conservative_inframe_insertion 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139654 c.99_101delTCA disruptive_inframe_deletion 0.76 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139699 c.57C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240699 c.837C>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embC 4240717 c.855T>C synonymous_variant 0.67 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.73 ethambutol Not assoc w R - Interim
embC 4240736 p.Ser292Ala missense_variant 0.76 ethambutol
embC 4240766 c.904C>A synonymous_variant 0.81 ethambutol
embC 4240774 c.912C>G synonymous_variant 0.82 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.8 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.8 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.81 ethambutol
embC 4240807 c.945C>G synonymous_variant 0.81 ethambutol Not assoc w R - Interim
embC 4240819 c.957A>C synonymous_variant 0.79 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.74 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.72 ethambutol
embC 4240867 c.1005T>A synonymous_variant 0.36 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.33 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.35 ethambutol
embC 4241024 p.Val388Phe missense_variant 0.35 ethambutol
embC 4241035 c.1173G>C synonymous_variant 0.33 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.34 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.33 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.31 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.33 ethambutol
embC 4241059 c.1197G>A synonymous_variant 0.36 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.53 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.6 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.68 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.73 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.72 ethambutol
embC 4241109 p.Ala416Gly missense_variant 0.73 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.79 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.79 ethambutol Uncertain significance
embC 4241146 c.1284C>G synonymous_variant 0.78 ethambutol
embC 4241147 p.Cys429Ile missense_variant 0.78 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.83 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.82 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.82 ethambutol
embC 4241167 c.1305C>A synonymous_variant 0.8 ethambutol
embC 4241179 c.1317G>C synonymous_variant 0.83 ethambutol
embC 4241195 p.Ser445Ala missense_variant 0.74 ethambutol
embC 4241198 p.Ile446Val missense_variant 0.69 ethambutol
embC 4241218 c.1356G>C synonymous_variant 0.43 ethambutol
embC 4241219 p.Ile453Val missense_variant 0.41 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.94 ethambutol Not assoc w R
embB 4247386 c.873T>C synonymous_variant 0.52 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.56 ethambutol
embB 4247398 c.885G>C synonymous_variant 0.57 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.6 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.77 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.79 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.8 ethambutol
embB 4247455 c.942C>T synonymous_variant 0.81 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.83 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.83 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.83 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.81 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.8 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.77 ethambutol
embB 4247528 p.Leu339Met missense_variant 0.69 ethambutol
embB 4247537 p.His342Ser missense_variant 0.45 ethambutol
embB 4247869 c.1356G>C synonymous_variant 0.61 ethambutol
embB 4247879 c.1366_1368delGTGinsCC frameshift_variant&missense_variant 0.61 ethambutol
embB 4247884 c.1371C>G synonymous_variant 0.61 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.65 ethambutol
embB 4247909 c.1396T>C synonymous_variant 0.59 ethambutol
embB 4247917 c.1404C>G synonymous_variant 0.61 ethambutol
embB 4247920 c.1407T>C synonymous_variant 0.61 ethambutol
embB 4247922 p.His470Arg missense_variant 0.61 ethambutol
embB 4247926 c.1413C>T synonymous_variant 0.61 ethambutol
embB 4247938 c.1425G>C synonymous_variant 0.59 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.61 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.62 ethambutol
embB 4247950 c.1437G>C synonymous_variant 0.59 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.61 ethambutol
embB 4247968 c.1455C>G synonymous_variant 0.58 ethambutol
embB 4247975 p.Val488Ile missense_variant 0.37 ethambutol Uncertain significance
embB 4248185 p.Leu558Met missense_variant 0.55 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.63 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.76 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.76 ethambutol
embB 4248217 c.1704C>G synonymous_variant 0.75 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.74 ethambutol
embB 4248226 c.1713G>A synonymous_variant 0.75 ethambutol Not assoc w R - Interim
embB 4248247 c.1734C>T synonymous_variant 0.76 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.79 ethambutol
embB 4248259 p.Met582Ile missense_variant 0.8 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.85 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.85 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.85 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.84 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.84 ethambutol
embB 4248328 c.1815G>C synonymous_variant 0.82 ethambutol
embB 4248334 c.1821C>G synonymous_variant 0.82 ethambutol
embB 4248341 p.Thr610Ala missense_variant 0.83 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.79 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.81 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.78 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.79 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.79 ethambutol
embB 4248379 c.1866G>A synonymous_variant 0.77 ethambutol
embB 4248395 c.1882_1884delTTCinsGG frameshift_variant&missense_variant 0.67 ethambutol
embB 4248403 c.1890G>C synonymous_variant 0.59 ethambutol
embB 4248407 c.1894_1896delTTAinsGG frameshift_variant&missense_variant 0.6 ethambutol
embB 4248421 c.1908G>C synonymous_variant 0.47 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 0.41 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.41 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
aftB 4268168 p.Ala223Leu missense_variant 0.3 ethambutol
aftB 4268176 c.660_661insTC frameshift_variant 0.33 ethambutol Uncertain significance
aftB 4268181 c.654_655delAT frameshift_variant 0.34 ethambutol Uncertain significance
aftB 4268192 c.645G>T synonymous_variant 0.34 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.34 ethambutol
aftB 4268210 c.627C>A synonymous_variant 0.35 ethambutol
aftB 4268217 c.619delT frameshift_variant 0.37 ethambutol Uncertain significance
aftB 4268222 c.614_615insC frameshift_variant 0.42 ethambutol Uncertain significance
aftB 4268225 c.612G>C synonymous_variant 0.4 ethambutol
aftB 4268233 p.Ile202Val missense_variant 0.43 ethambutol Uncertain significance
aftB 4268243 c.592_594delATCinsGG frameshift_variant&missense_variant 0.45 ethambutol Uncertain significance
aftB 4268251 c.584_585delTG frameshift_variant 0.5 ethambutol Uncertain significance
aftB 4268255 c.581_582insCG frameshift_variant 0.48 ethambutol Uncertain significance
aftB 4269042 c.-206G>C upstream_gene_variant 0.27 ethambutol
aftB 4269045 c.-209G>C upstream_gene_variant 0.28 ethambutol
aftB 4269048 c.-212C>T upstream_gene_variant 0.29 ethambutol
ubiA 4269066 c.768C>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
ethA 4326509 p.Ala322Lys missense_variant 0.24 ethionamide
ethA 4326555 p.His307Asn missense_variant 0.24 ethionamide
ethR 4326567 c.-982G>T upstream_gene_variant 0.28 ethionamide
ethA 4326603 p.Gln291Glu missense_variant 0.28 ethionamide
ethR 4326610 c.-939G>C upstream_gene_variant 0.32 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R