TB-Profiler result

Run: SRR3742657
Summary

Run ID: SRR3742657

Sample name:

Date: 2024-04-16T03:40:34.793117

Number of reads: 3298004

Percentage reads mapped: 40.25

Median coverage: 75.0

Strain: La3;M.canetti;lineage2.2.1

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.95
lineage6.2.2 West-Africa 2 RD702 0.05
La1.2.BCG M.bovis None 0.25
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.92
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
lineage6.2.3 West-Africa 2 RD702 0.19
La1.7.1 M.bovis None 0.08
La3 M.orygis None 0.23
M.canetti M.canetti None 0.06
lineage6.2.1 West-Africa 2 RD702 0.09
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG c.-2237_*6541del Assoc w R High-level resistance
ahpC c.-81C>T Uncertain significance Mutation from literature
ethambutol embA c.-16C>T Uncertain significance Mutation from literature
embB p.His312Arg Mutation from literature
p.Tyr384Asn Mutation from literature
p.Ala388Gly Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide pncA p.Val180Gly Assoc w R
panD p.Val138Ala Mutation from literature
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
n.514A>C Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
p.Ser91Pro Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
p.Ser91Pro Assoc w R
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>T Assoc w R - Interim
capreomycin rrs n.1402C>T Assoc w R
tlyA c.319_321delCACinsGA Assoc w R
c.376_378delCCTinsGG Assoc w R
kanamycin rrs n.1402C>T Assoc w R - Interim
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.202_204delCTGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1024_1026delGAAinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiA c.358_360delCAGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 0.71 levofloxacin Assoc w R
moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
gyrA 7572 p.Ser91Pro missense_variant 0.71 levofloxacin Assoc w R
moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
fgd1 490984 c.202_204delCTGinsAC frameshift_variant&missense_variant 0.41 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.34 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.56 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761110 p.Asp435Val missense_variant 0.19 rifampicin Assoc w R
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.51 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303954 c.1024_1026delGAAinsCG frameshift_variant&missense_variant 0.4 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance Mutation from literature
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 0.26 streptomycin Assoc w R
rrs 1473247 n.1402C>T non_coding_transcript_exon_variant 0.32 capreomycin Assoc w R
amikacin Assoc w R - Interim
kanamycin Assoc w R - Interim
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
tlyA 1918258 c.319_321delCACinsGA frameshift_variant&missense_variant 0.26 capreomycin Assoc w R
tlyA 1918315 c.376_378delCCTinsGG frameshift_variant&missense_variant 0.24 capreomycin Assoc w R
katG 2147347 c.-2237_*6541del transcript_ablation 0.99 isoniazid Assoc w R High-level resistance
pncA 2288703 p.Val180Gly missense_variant 1.0 pyrazinamide Assoc w R
ahpC 2726112 c.-81C>T upstream_gene_variant 1.0 isoniazid Uncertain significance Mutation from literature
fbiA 3640900 c.358_360delCAGinsAC frameshift_variant&missense_variant 0.48 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
panD 4043869 p.Val138Ala missense_variant 0.38 pyrazinamide Mutation from literature
embA 4243217 c.-16C>T upstream_gene_variant 0.9 ethambutol Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.56 ethambutol Mutation from literature
embB 4247663 p.Tyr384Asn missense_variant 0.3 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.37 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.42 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.36 isoniazid
dnaA 42 c.42C>T synonymous_variant 0.28 isoniazid
dnaA 51 c.51C>T synonymous_variant 0.19 isoniazid
dnaA 195 c.195G>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 207 c.207T>C synonymous_variant 0.22 isoniazid
dnaA 210 c.210C>G synonymous_variant 0.22 isoniazid
dnaA 219 c.219A>G synonymous_variant 0.25 isoniazid
dnaA 225 c.225G>A synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 228 c.228C>G synonymous_variant 0.25 isoniazid
dnaA 510 c.510T>C synonymous_variant 0.3 isoniazid
dnaA 519 c.519C>G synonymous_variant 0.34 isoniazid Not assoc w R
dnaA 522 c.522T>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
dnaA 525 c.525T>C synonymous_variant 0.37 isoniazid
dnaA 534 c.534T>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>C synonymous_variant 0.54 isoniazid
dnaA 561 c.561C>T synonymous_variant 0.55 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.58 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.59 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.58 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.58 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.58 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.59 isoniazid
dnaA 600 c.600T>G synonymous_variant 0.6 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.57 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.41 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.32 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.27 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 675 c.675C>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.24 isoniazid
dnaA 682 c.682T>C synonymous_variant 0.25 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.36 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.38 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.39 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.37 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.37 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.39 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.42 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.4 isoniazid
dnaA 792 c.792C>T synonymous_variant 0.33 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.22 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.18 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.3 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.3 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.34 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.39 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.42 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.44 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.51 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.5 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.47 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.44 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.42 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.4 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.45 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.45 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.4 isoniazid
dnaA 996 c.996A>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 999 c.999C>G synonymous_variant 0.41 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.42 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.58 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.49 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.48 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.47 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.46 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.44 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.42 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.43 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.33 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.31 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.27 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.25 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.32 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.39 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.41 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.5 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.48 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.47 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.49 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.49 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.51 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.53 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.51 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.48 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.44 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.42 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>G synonymous_variant 0.35 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.21 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.35 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.37 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.4 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.4 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.41 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.42 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.46 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.49 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.48 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.51 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.56 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.5 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.48 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.4 isoniazid
dnaA 1485 c.1485A>G synonymous_variant 0.33 isoniazid
dnaA 1488 c.1488A>G synonymous_variant 0.35 isoniazid
dnaA 1497 c.1497T>C synonymous_variant 0.31 isoniazid
dnaA 1506 c.1506T>G synonymous_variant 0.28 isoniazid
gyrB 5396 p.Ala53Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 5782 c.543A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 5788 c.549G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 5791 c.552A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 5803 c.564A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 5806 c.567C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 5809 c.570C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 5812 c.573C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrB 5849 c.610C>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrB 5863 c.624G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 5873 c.634A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrB 5880 p.Thr214Ser missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 5882 c.643_645delCAAinsAC frameshift_variant&missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin
gyrB 5887 p.Asp216Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrB 5902 c.663A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 5905 c.666G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6091 c.852G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6100 c.861G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.39 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.4 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6670 c.1431G>A synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.62 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6787 c.-515G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.5 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.45 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7075 c.-227T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7246 c.2007T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7252 c.-50G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7256 c.2017_2019delCTGinsTA frameshift_variant&stop_gained 0.19 levofloxacin Uncertain significance
moxifloxacin
gyrA 7307 c.6A>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7317 c.16T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7324 c.23_24insAGG disruptive_inframe_insertion 0.27 levofloxacin
moxifloxacin
gyrA 7334 c.33G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7335 p.Leu12Val missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7347 c.46_48delGAAinsCG frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7712 p.Leu137Phe missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7853 c.552C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.52 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.54 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8780 p.Asp493Glu missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.61 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.41 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9032 c.1731T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9056 c.1755C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.61 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.68 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9386 c.2085T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9413 c.2112G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9602 c.2301T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9611 p.Asp770Glu missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9626 c.2325T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9629 c.2328C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9630 p.Val777Ile missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9638 c.2337C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9641 c.2340C>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9650 c.2349G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9656 c.2355C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9665 c.2364A>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9704 c.2403T>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9708 c.2407T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9716 c.2415T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9727 p.Gly809Glu missense_variant 0.51 levofloxacin
moxifloxacin
gyrA 9729 p.Asp810Asn missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 9734 c.2433A>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9749 c.2448G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9755 c.2454C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
Rv0010c 13291 p.Asp90Asn missense_variant 0.2 isoniazid
Rv0010c 13320 p.Arg80Leu missense_variant 0.2 isoniazid
Rv0010c 13349 p.Ile70Met missense_variant 0.21 isoniazid
Rv0010c 13879 c.-321T>C upstream_gene_variant 0.22 isoniazid
Rv0010c 13890 c.-332T>C upstream_gene_variant 0.3 isoniazid
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.31 isoniazid
Rv0010c 13897 c.-339C>T upstream_gene_variant 0.33 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.36 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.35 isoniazid
fgd1 490782 c.-1G>C upstream_gene_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 490797 c.15G>A synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.48 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.63 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 490977 c.195C>G synonymous_variant 0.39 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 490980 p.Asn66Lys missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490987 p.Leu69Thr missense_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491001 c.219G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491173 c.391C>A synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.32 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491535 c.753G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.63 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491697 c.915G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575011 c.-337G>A upstream_gene_variant 0.21 ethionamide
isoniazid
mshA 575018 c.-330C>G upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 575022 c.-326C>T upstream_gene_variant 0.32 ethionamide
isoniazid
mshA 575030 c.-318T>C upstream_gene_variant 0.32 ethionamide
isoniazid
mshA 575034 c.-314_-312delTTAinsAG upstream_gene_variant 0.33 ethionamide
isoniazid
mshA 575042 c.-306T>C upstream_gene_variant 0.32 ethionamide
isoniazid
mshA 575052 c.-296G>C upstream_gene_variant 0.35 ethionamide
isoniazid
mshA 575057 c.-291G>C upstream_gene_variant 0.36 ethionamide
isoniazid
mshA 575060 c.-288G>C upstream_gene_variant 0.36 ethionamide
isoniazid
mshA 575063 c.-285T>C upstream_gene_variant 0.36 ethionamide
isoniazid
mshA 575075 c.-273T>C upstream_gene_variant 0.43 ethionamide
isoniazid Uncertain significance
mshA 575084 c.-264T>C upstream_gene_variant 0.53 ethionamide
isoniazid
mshA 575117 c.-231T>C upstream_gene_variant 0.51 ethionamide
isoniazid
mshA 575118 c.-230_-228delACGinsGC upstream_gene_variant 0.51 ethionamide
isoniazid
mshA 575124 c.-224_-222delGGGinsCC upstream_gene_variant 0.51 ethionamide
isoniazid
mshA 575137 c.-211C>G upstream_gene_variant 0.56 ethionamide
isoniazid
mshA 575144 c.-204T>C upstream_gene_variant 0.56 ethionamide
isoniazid
mshA 575154 c.-194_-192delGTGinsCC upstream_gene_variant 0.53 ethionamide
isoniazid
mshA 575161 c.-187T>C upstream_gene_variant 0.54 ethionamide
isoniazid
mshA 575521 c.174A>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575527 c.180G>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575536 c.189T>C synonymous_variant 0.46 ethionamide
isoniazid
mshA 575542 c.195C>A synonymous_variant 0.45 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.45 ethionamide
isoniazid
mshA 575569 c.222A>G synonymous_variant 0.45 ethionamide
isoniazid
mshA 575571 p.Ser75Thr missense_variant 0.45 ethionamide
isoniazid
mshA 575576 c.229C>T synonymous_variant 0.46 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575581 c.234C>T synonymous_variant 0.47 ethionamide
isoniazid
mshA 575587 c.240C>G synonymous_variant 0.46 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.46 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.4 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.46 ethionamide
isoniazid
mshA 575662 c.315C>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575665 c.318G>A synonymous_variant 0.44 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.48 ethionamide
isoniazid
mshA 575695 c.348C>A synonymous_variant 0.46 ethionamide
isoniazid
mshA 575701 c.354G>A synonymous_variant 0.45 ethionamide
isoniazid
mshA 575704 c.357T>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.47 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.47 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.51 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.49 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.42 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.42 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.43 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.43 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.45 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.46 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.59 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.59 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.57 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.59 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.58 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.56 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.59 ethionamide
isoniazid Not assoc w R - Interim
mshA 575864 c.517T>C synonymous_variant 0.65 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.63 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.62 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.61 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.41 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575917 p.Asp190Glu missense_variant 0.52 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.52 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.52 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.47 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.39 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>T upstream_gene_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.57 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619668 c.-223_-222delCGinsGC upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>T upstream_gene_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 619676 c.-215C>G upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619697 c.-194_-192delAGGinsCC upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619705 c.-186G>C upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620298 c.408G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>T synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.53 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.49 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620481 c.591T>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620482 p.Val198Leu missense_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656052 c.1419A>C synonymous_variant 0.39 ethionamide
Rv0565c 656073 c.1396_1398delTTGinsCC frameshift_variant&missense_variant 0.39 ethionamide Uncertain significance
Rv0565c 656076 c.1395C>T synonymous_variant 0.39 ethionamide
Rv0565c 656085 c.1386A>G synonymous_variant 0.37 ethionamide
Rv0565c 656088 c.1383A>G synonymous_variant 0.36 ethionamide
Rv0565c 656091 c.1380T>C synonymous_variant 0.35 ethionamide
Rv0565c 656100 c.1371G>C synonymous_variant 0.36 ethionamide
Rv0565c 656112 c.1359C>G synonymous_variant 0.37 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.43 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.43 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.43 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.4 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.4 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.38 ethionamide
Rv0565c 656325 c.1146C>G synonymous_variant 0.38 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.23 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.35 ethionamide
Rv0565c 656412 c.1059T>C synonymous_variant 0.38 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.44 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.44 ethionamide
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.52 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.52 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.5 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.5 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.51 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.5 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.47 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.46 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.42 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.39 ethionamide Not assoc w R - Interim
Rv0565c 656526 p.Glu315Asp missense_variant 0.34 ethionamide
Rv0565c 656535 c.936C>G synonymous_variant 0.27 ethionamide
Rv0565c 656539 p.Ser311Ala missense_variant 0.25 ethionamide
Rv0565c 656946 c.525T>C synonymous_variant 0.21 ethionamide
Rv0565c 656978 p.Ala165Thr missense_variant 0.19 ethionamide
Rv0565c 656983 p.Gly163Asp missense_variant 0.19 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657219 p.Ala84Val missense_variant 0.27 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.4 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.44 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.49 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.48 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.49 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.51 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.62 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.65 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.63 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.6 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.64 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.63 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.62 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.62 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.68 ethionamide
Rv0565c 657372 c.99G>C synonymous_variant 0.62 ethionamide
Rv0565c 657375 c.96C>T synonymous_variant 0.6 ethionamide
Rv0565c 657385 p.Ile29Thr missense_variant 0.52 ethionamide
Rv0565c 657399 c.72G>C synonymous_variant 0.33 ethionamide
Rv0565c 657403 p.Gly23Asp missense_variant 0.34 ethionamide
Rv0565c 657405 c.64_66delCTGinsAT frameshift_variant&missense_variant 0.33 ethionamide Uncertain significance
Rv0565c 657408 c.63A>C synonymous_variant 0.31 ethionamide
Rv0565c 657560 c.-90G>C upstream_gene_variant 0.26 ethionamide
Rv0565c 657563 c.-93T>C upstream_gene_variant 0.3 ethionamide
Rv0565c 657571 c.-101T>C upstream_gene_variant 0.32 ethionamide
Rv0565c 657572 c.-102A>G upstream_gene_variant 0.31 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.4 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.47 ethionamide
Rv0565c 657600 c.-132_-131delCA upstream_gene_variant 0.49 ethionamide
Rv0565c 657606 c.-136T>G upstream_gene_variant 0.48 ethionamide
Rv0565c 657607 c.-138_-137insCA upstream_gene_variant 0.49 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.69 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.71 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.7 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.68 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.63 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.6 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.42 ethionamide
hadA 731717 c.-213T>G upstream_gene_variant 0.28 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.47 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.5 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.57 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.59 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.58 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.56 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.52 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.39 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.38 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.34 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.34 isoniazid
hadA 731864 c.-66C>T upstream_gene_variant 0.22 isoniazid
hadA 732238 c.309G>C synonymous_variant 0.22 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.38 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.46 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.49 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.48 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.51 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.65 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.67 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.68 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.67 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.72 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.7 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.67 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.71 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.71 isoniazid
nusG 734078 c.-176C>G upstream_gene_variant 0.32 rifampicin Uncertain significance
nusG 734093 c.-161A>C upstream_gene_variant 0.34 rifampicin
nusG 734096 c.-158C>T upstream_gene_variant 0.34 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.34 rifampicin
nusG 734111 c.-143A>G upstream_gene_variant 0.34 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.34 rifampicin
nusG 734120 c.-134T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
nusG 734123 c.-131C>G upstream_gene_variant 0.36 rifampicin
nusG 734129 c.-125G>C upstream_gene_variant 0.36 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.35 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.35 rifampicin
nusG 734144 c.-110G>C upstream_gene_variant 0.35 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.33 rifampicin
nusG 734340 c.87T>C synonymous_variant 0.27 rifampicin
nusG 734352 c.99T>C synonymous_variant 0.42 rifampicin
nusG 734360 p.Ala36Val missense_variant 0.53 rifampicin Uncertain significance
nusG 734370 c.117A>G synonymous_variant 0.59 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.6 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.73 rifampicin
nusG 734418 c.165C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
nusG 734421 c.168A>G synonymous_variant 0.76 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.78 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.75 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.76 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.75 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.74 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.75 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.76 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.69 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.67 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.65 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.64 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.5 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.44 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.42 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.43 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.42 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.36 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.27 rifampicin Not assoc w R
nusG 734673 c.420A>G synonymous_variant 0.25 rifampicin
nusG 734676 c.423G>C synonymous_variant 0.24 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734680 p.Ala143Thr missense_variant 0.22 rifampicin
nusG 734772 c.519G>C synonymous_variant 0.22 rifampicin
nusG 734775 c.522C>G synonymous_variant 0.24 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.24 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.25 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.27 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.33 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.37 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.67 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.68 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.67 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.66 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.68 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.67 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.67 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.61 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.59 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.34 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.32 rifampicin
rpoB 760030 p.Asn75Thr missense_variant 0.2 rifampicin Uncertain significance
rpoB 760034 c.228A>G synonymous_variant 0.26 rifampicin
rpoB 760040 c.234T>C synonymous_variant 0.28 rifampicin
rpoB 760046 c.240G>C synonymous_variant 0.35 rifampicin
rpoB 760060 p.Tyr85Leu missense_variant 0.41 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.46 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.5 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.61 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.64 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.66 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.73 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.68 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.68 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.7 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.69 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.68 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.69 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.65 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.63 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.62 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760472 c.666C>T synonymous_variant 0.56 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.6 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.56 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.61 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.67 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.78 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760680 p.Asn292Asp missense_variant 0.24 rifampicin
rpoB 760683 c.877T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.66 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.64 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.53 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.46 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.46 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.43 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.42 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.43 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.5 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.54 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.53 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.55 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.61 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.63 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.68 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.66 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.63 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.62 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.62 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.72 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.71 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.78 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.7 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.69 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.67 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.71 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.7 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.67 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.65 rifampicin
rpoB 761373 p.Val523His missense_variant 0.61 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.55 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.43 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.34 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.32 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.33 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.31 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.31 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.32 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.41 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.55 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.6 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.68 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.72 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.74 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.74 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.71 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.61 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.33 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.29 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.36 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.46 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.5 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.53 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.53 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.57 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.58 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.65 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.66 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.7 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.64 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.66 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.69 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.79 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.74 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.67 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.65 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.65 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.64 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.65 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.78 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.68 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.68 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.68 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.72 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.83 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.81 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.81 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.79 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.78 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.72 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.7 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.73 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.73 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.68 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.68 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.69 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.71 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.69 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.68 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.65 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.64 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.65 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.66 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.68 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.62 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.61 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.61 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.55 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.36 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.36 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.26 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.3 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.32 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.34 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.39 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.42 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.64 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.65 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.36 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.65 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.54 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.54 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.56 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.54 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.53 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.52 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.58 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.42 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.4 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763351 c.-19T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoC 763402 c.33C>G synonymous_variant 0.61 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.67 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.63 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.61 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.68 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.68 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.69 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.68 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.67 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.69 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.7 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.61 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.57 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.59 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.59 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.56 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.56 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.56 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.54 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.56 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.57 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.58 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.56 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.51 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.51 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.53 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.48 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.43 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.44 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.51 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.56 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.6 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.61 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.6 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.56 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.57 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.59 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.57 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.52 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.52 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.56 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.57 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.36 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 764392 c.1023C>T synonymous_variant 0.36 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.51 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.53 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.52 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.54 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.63 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.68 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.71 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.7 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.69 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.62 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.55 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.56 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.68 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.67 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.55 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.47 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.55 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.36 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.34 rifampicin
rpoC 765208 c.1839T>C synonymous_variant 0.22 rifampicin
rpoC 765220 c.1851A>G synonymous_variant 0.26 rifampicin
rpoC 765233 p.Ala622Ser missense_variant 0.27 rifampicin
rpoC 765241 c.1872C>T synonymous_variant 0.27 rifampicin
rpoC 765244 c.1875T>C synonymous_variant 0.28 rifampicin
rpoC 765247 c.1878C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765248 c.1879T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765251 c.1882_1884delAGCinsTCG synonymous_variant 0.29 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.5 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.42 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.41 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.49 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.52 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.59 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765364 c.1995G>A synonymous_variant 0.6 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.64 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.7 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.7 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.68 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.67 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.63 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.63 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.66 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.65 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.65 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.67 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.66 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.64 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.64 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.61 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.61 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.63 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.62 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.7 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.7 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.7 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.65 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.67 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.66 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.69 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.69 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.72 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.74 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.69 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.61 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766174 p.Asn935Lys missense_variant 0.26 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.26 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.34 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.34 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.37 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.43 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.49 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.55 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.56 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.55 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.55 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.56 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.57 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.59 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.61 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.61 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.61 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.63 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.67 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.71 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.72 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.69 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.69 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.71 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.62 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.63 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.65 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.69 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.68 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.69 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.69 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.69 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.67 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.67 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.69 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.74 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.68 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.64 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.64 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.71 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.7 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.76 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.72 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.75 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.76 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.76 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.7 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.64 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.63 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.62 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.7 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.73 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.66 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.62 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.23 rifampicin
rpoC 767284 c.3915C>T synonymous_variant 0.2 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775961 c.2520C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.31 clofazimine
bedaquiline
mmpL5 775973 c.2506_2508delTTGinsCC frameshift_variant&missense_variant 0.24 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775981 p.Leu834Met missense_variant 0.31 clofazimine
bedaquiline
mmpL5 775991 c.2490G>A synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.32 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776005 p.Ile826Leu missense_variant 0.27 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 776030 c.2451G>A synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpL5 776646 p.Val612Thr missense_variant 0.22 clofazimine
bedaquiline
mmpL5 776654 c.1827A>C synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 776664 p.Thr606Gly missense_variant 0.3 clofazimine
bedaquiline
mmpL5 776675 c.1806G>A synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 776678 c.1803G>C synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 776684 c.1797G>A synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776693 p.Val596Ala missense_variant 0.35 clofazimine
bedaquiline
mmpL5 776705 c.1776C>T synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 776738 p.Ile581Met missense_variant 0.3 clofazimine
bedaquiline
mmpL5 776741 c.1740C>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 776756 p.Asp575Glu missense_variant 0.25 clofazimine
bedaquiline
mmpL5 777095 c.1386T>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 777101 c.1380C>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 777110 c.1371T>G synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 777115 p.Met456Leu missense_variant 0.37 clofazimine
bedaquiline
mmpL5 777116 c.1365C>T synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 777133 p.Val450Ile missense_variant 0.46 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.54 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.53 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.53 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.53 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.46 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 777212 c.1267_1269delGCCinsAG frameshift_variant&missense_variant 0.41 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777215 c.1266C>G synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.41 clofazimine
bedaquiline
mmpL5 777251 c.1230C>G synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777254 c.1227G>C synonymous_variant 0.22 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781182 c.-378G>C upstream_gene_variant 0.25 streptomycin
rpsL 781185 c.-375T>C upstream_gene_variant 0.29 streptomycin
rpsL 781194 c.-366G>C upstream_gene_variant 0.4 streptomycin
rpsL 781197 c.-363A>G upstream_gene_variant 0.4 streptomycin
rpsL 781224 c.-336T>C upstream_gene_variant 0.41 streptomycin
rpsL 781230 c.-330T>C upstream_gene_variant 0.42 streptomycin
rpsL 781232 c.-328C>T upstream_gene_variant 0.42 streptomycin
rpsL 781234 c.-326G>T upstream_gene_variant 0.43 streptomycin
rpsL 781240 c.-320A>T upstream_gene_variant 0.43 streptomycin
rpsL 781257 c.-303G>C upstream_gene_variant 0.41 streptomycin
rpsL 781269 c.-291C>T upstream_gene_variant 0.38 streptomycin
rpsL 781270 c.-290A>C upstream_gene_variant 0.36 streptomycin
rpsL 781276 c.-284A>C upstream_gene_variant 0.33 streptomycin
rpsL 781285 c.-275_-273delACAinsGC upstream_gene_variant 0.25 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.44 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.62 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.62 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.62 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.71 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.73 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.76 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.77 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.71 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.75 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.75 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.78 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.79 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.76 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.75 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.76 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.76 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.75 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.78 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.74 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.73 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.71 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.72 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.72 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.68 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.67 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.68 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.67 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.69 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.72 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.7 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.7 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.47 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.55 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.55 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.59 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.65 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.63 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.63 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.64 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.64 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.62 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.63 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.68 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.67 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.65 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.65 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.66 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.68 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.68 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.63 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.62 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.62 linezolid
rplC 800814 c.6A>G synonymous_variant 0.62 linezolid
rplC 800817 c.9A>T synonymous_variant 0.6 linezolid
rplC 800844 c.36T>C synonymous_variant 0.68 linezolid
rplC 800865 c.57A>G synonymous_variant 0.55 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.54 linezolid
rplC 800874 c.66A>G synonymous_variant 0.52 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.52 linezolid
rplC 800880 c.72A>G synonymous_variant 0.53 linezolid
rplC 800889 c.81C>G synonymous_variant 0.52 linezolid
rplC 800892 c.84G>C synonymous_variant 0.51 linezolid
rplC 800907 c.99C>G synonymous_variant 0.51 linezolid
rplC 800916 c.108A>G synonymous_variant 0.52 linezolid
rplC 800934 c.126C>G synonymous_variant 0.41 linezolid
rplC 800937 c.129A>G synonymous_variant 0.33 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.34 linezolid
rplC 800946 c.138T>C synonymous_variant 0.35 linezolid
rplC 800949 c.141T>C synonymous_variant 0.36 linezolid
rplC 800967 c.159C>G synonymous_variant 0.37 linezolid
rplC 800970 c.162T>C synonymous_variant 0.36 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.44 linezolid
rplC 800985 c.177A>G synonymous_variant 0.45 linezolid
rplC 801004 p.Leu66Val missense_variant 0.29 linezolid
rplC 801009 c.201A>C synonymous_variant 0.3 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.34 linezolid
rplC 801132 c.324T>C synonymous_variant 0.38 linezolid
rplC 801147 c.339T>C synonymous_variant 0.47 linezolid
rplC 801150 c.342G>C synonymous_variant 0.51 linezolid
rplC 801153 c.345G>C synonymous_variant 0.5 linezolid
rplC 801156 c.348T>A synonymous_variant 0.5 linezolid
rplC 801168 c.360C>G synonymous_variant 0.56 linezolid
rplC 801171 c.363A>G synonymous_variant 0.55 linezolid
rplC 801174 c.366T>C synonymous_variant 0.56 linezolid
rplC 801195 c.387G>C synonymous_variant 0.57 linezolid
rplC 801207 c.399C>T synonymous_variant 0.57 linezolid
rplC 801246 c.438C>T synonymous_variant 0.4 linezolid
rplC 801249 c.441T>C synonymous_variant 0.4 linezolid
rplC 801255 c.447C>T synonymous_variant 0.35 linezolid
rplC 801264 c.456C>T synonymous_variant 0.31 linezolid
rplC 801267 c.459A>T synonymous_variant 0.33 linezolid
rplC 801270 c.462T>C synonymous_variant 0.33 linezolid
rplC 801276 c.468G>C synonymous_variant 0.31 linezolid
rplC 801279 c.471G>C synonymous_variant 0.31 linezolid
rplC 801282 c.474G>C synonymous_variant 0.31 linezolid
rplC 801285 c.477G>C synonymous_variant 0.31 linezolid
rplC 801300 c.492C>G synonymous_variant 0.43 linezolid
rplC 801309 c.501C>G synonymous_variant 0.39 linezolid
rplC 801312 c.504G>C synonymous_variant 0.42 linezolid
rplC 801321 c.513C>T synonymous_variant 0.48 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.47 linezolid
rplC 801339 c.531T>C synonymous_variant 0.53 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.52 linezolid
rplC 801348 c.540T>G synonymous_variant 0.57 linezolid
rplC 801357 c.549T>C synonymous_variant 0.63 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.66 linezolid
rplC 801402 c.594T>C synonymous_variant 0.61 linezolid
rplC 801405 c.597T>C synonymous_variant 0.61 linezolid
rplC 801423 c.615G>C synonymous_variant 0.55 linezolid
rplC 801426 c.618C>G synonymous_variant 0.53 linezolid
rplC 801427 p.Met207Val missense_variant 0.53 linezolid
rplC 801438 c.630T>C synonymous_variant 0.58 linezolid
rplC 801442 p.Ile212Val missense_variant 0.58 linezolid
Rv1129c 1254056 p.Asp160Ala missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303470 c.540T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303476 c.546G>C synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303489 c.559C>T synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303497 c.567G>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.51 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ser missense_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304208 c.1278C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304223 c.1293G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304226 c.1296C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304227 p.Met433Leu missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.5 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.67 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305081 c.2151G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305177 c.2247A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305181 c.2251T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305186 c.2256C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305195 c.2265T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305201 c.2271G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305210 c.2280G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305215 p.Ser762Thr missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305234 c.2304G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305372 c.2442G>A synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305384 c.2454G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305396 c.2466C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305417 c.2487C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305430 p.Val834Thr missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305444 c.2514A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
sigE 1364856 c.444C>G synonymous_variant 0.28 pyrazinamide
sigE 1364862 c.450C>A synonymous_variant 0.31 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.31 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.35 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.43 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.45 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.42 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.4 pyrazinamide
sigE 1364943 c.531C>T synonymous_variant 0.31 pyrazinamide
sigE 1364949 c.537C>T synonymous_variant 0.22 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.2 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.24 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.29 pyrazinamide
sigE 1365036 c.624T>C synonymous_variant 0.36 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.42 pyrazinamide
sigE 1365057 c.645C>T synonymous_variant 0.46 pyrazinamide
sigE 1365063 c.651A>C synonymous_variant 0.47 pyrazinamide
sigE 1365084 c.672G>C synonymous_variant 0.4 pyrazinamide
sigE 1365087 c.675A>C synonymous_variant 0.39 pyrazinamide
sigE 1365090 c.678T>C synonymous_variant 0.39 pyrazinamide
sigE 1365096 c.684G>C synonymous_variant 0.38 pyrazinamide
sigE 1365099 c.687A>C synonymous_variant 0.39 pyrazinamide
sigE 1365114 c.702G>A synonymous_variant 0.38 pyrazinamide
sigE 1365117 c.705A>C synonymous_variant 0.35 pyrazinamide
sigE 1365118 c.706C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1365135 c.723A>C synonymous_variant 0.26 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1460816 c.-229T>C upstream_gene_variant 0.43 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.53 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.55 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.55 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.54 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.53 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.56 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.49 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.46 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.43 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.43 bedaquiline
atpE 1460915 c.-130C>G upstream_gene_variant 0.31 bedaquiline
atpE 1460918 c.-127A>G upstream_gene_variant 0.27 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.38 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.39 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.39 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.35 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.35 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.45 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.49 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.48 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.44 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.38 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.32 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.32 bedaquiline
atpE 1461275 c.231T>A synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473417 n.-241C>T upstream_gene_variant 0.28 capreomycin
linezolid
rrl 1473419 n.-239T>C upstream_gene_variant 0.28 capreomycin
linezolid
rrl 1473420 n.-238A>G upstream_gene_variant 0.27 capreomycin
linezolid
rrl 1473421 n.-237G>A upstream_gene_variant 0.27 capreomycin
linezolid
rrl 1473436 n.-222T>C upstream_gene_variant 0.24 capreomycin
linezolid
rrl 1473437 n.-221T>C upstream_gene_variant 0.24 capreomycin
linezolid
rrl 1473653 n.-5_2delTGTGTTTinsGTGTAA non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474362