TB-Profiler result

Run: SRR20969708
Summary

Run ID: SRR20969708

Sample name:

Date: 2024-04-16T08:26:51.816519

Number of reads: 2896463

Percentage reads mapped: 29.3

Median coverage: 38.0

Strain: lineage2.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
p.Ala388Gly Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ofloxacin
levofloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine mmpR5 c.-1_*365del Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
para-aminosalicylic_acid
delamanid fgd1 c.280_282delGGAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.295_297delAACinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.658_660delCGAinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2026_2028delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline mmpR5 c.-1_*365del Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6738 p.Thr500Asn missense_variant 0.34 levofloxacin Uncertain significance Mutation from literature
moxifloxacin Uncertain significance Mutation from literature
fgd1 491062 c.280_282delGGAinsAC frameshift_variant&missense_variant 0.37 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491077 c.295_297delAACinsCG frameshift_variant&missense_variant 0.39 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
mmpR5 778988 c.-1_*365del transcript_ablation 1.0 clofazimine Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
bedaquiline Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.57 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303588 c.658_660delCGAinsAG frameshift_variant&synonymous_variant 0.67 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304956 c.2026_2028delGTTinsAC frameshift_variant&missense_variant 0.44 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.57 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance Mutation from literature
inhA 1673425 c.-777C>T upstream_gene_variant 0.94 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
embB 4247580 p.Ala356Val missense_variant 0.74 ethambutol Uncertain significance Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.64 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 699 c.699G>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.36 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.39 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.49 isoniazid
dnaA 723 c.723A>G synonymous_variant 0.5 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.57 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.58 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.61 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.63 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.62 isoniazid Uncertain significance
dnaA 798 c.798C>T synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 801 c.801G>C synonymous_variant 0.62 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.62 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.64 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.64 isoniazid Not assoc w R - Interim
dnaA 840 c.840G>A synonymous_variant 0.62 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.58 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.58 isoniazid
dnaA 864 c.864C>T synonymous_variant 0.49 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.4 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.31 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.24 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.27 isoniazid
dnaA 1143 c.1143G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1173 c.1173C>T synonymous_variant 0.26 isoniazid
dnaA 1175 p.Lys392Arg missense_variant 0.27 isoniazid
dnaA 1179 c.1179G>A synonymous_variant 0.26 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.25 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.25 isoniazid
gyrB 6157 c.918C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6170 p.His311Ala missense_variant 0.43 levofloxacin
moxifloxacin
gyrB 6203 c.964_966delAGCinsTCG synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAGC synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrB 6229 c.990G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.51 levofloxacin
moxifloxacin
gyrB 6248 c.1009_1011delCTAinsTG frameshift_variant&stop_gained 0.5 levofloxacin Uncertain significance
moxifloxacin
gyrB 6253 c.1014G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.34 levofloxacin
moxifloxacin
gyrB 6329 p.Glu364Gln missense_variant 0.34 levofloxacin
moxifloxacin
gyrB 6358 c.1119C>G synonymous_variant 0.34 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6361 c.-941G>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6541 c.1302C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6550 c.1311A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6571 c.-731T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6582 p.Thr448Asn missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 6586 c.-716T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6590 p.Arg451Ala missense_variant 0.36 levofloxacin
moxifloxacin
gyrB 6597 p.Ser453Cys missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6625 c.-677G>A upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6688 c.-614C>G upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6730 c.-572A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.28 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6817 c.1578G>A synonymous_variant 0.33 levofloxacin Not assoc w R
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6931 c.-371A>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6971 p.Pro578Ala missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6988 c.-314C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6997 c.-305G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7046 p.Lys603Val missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 7057 c.1818C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7313 c.12G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7317 c.16T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7322 c.21G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7335 c.34_36delCTCinsGG frameshift_variant&missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 7340 p.Asp13Glu missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 7349 c.48A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7418 c.117C>G synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrA 7421 c.120G>A synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.79 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7526 c.225G>C synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7569 p.Ala90Ser missense_variant 0.75 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7625 c.324G>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7655 c.354G>A synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 7697 c.396C>T synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7715 c.414G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.83 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>T synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.69 levofloxacin
moxifloxacin
gyrA 7911 p.Ala204Cys missense_variant 0.61 levofloxacin
moxifloxacin
gyrA 7922 c.621T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7928 p.Asp209Glu missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 7934 c.633C>T synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7942 p.Glu214Ala missense_variant 0.52 levofloxacin
moxifloxacin
gyrA 7951 p.Ala217Glu missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 7958 c.657C>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7963 p.Gly221Glu missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7970 c.669T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7973 c.672A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7988 c.687G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7992 p.Ala231Ser missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7997 c.696A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 8258 c.957G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8273 c.972C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.75 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8366 c.1065G>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.78 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.75 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.75 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8417 c.1116C>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8492 c.1191G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8585 c.1284C>T synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8591 c.1290C>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8600 c.1299G>A synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8606 c.1305C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>G synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8649 p.Arg450Lys missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8711 c.1410A>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8720 c.1419G>A synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.75 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.75 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8769 p.His490Tyr missense_variant 0.76 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8786 c.1485T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8788 p.Thr496Ser missense_variant 0.82 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.87 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8993 c.1692C>T synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.87 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 9064 p.Ser588Leu missense_variant 0.8 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>A synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.84 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.84 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9146 c.1845C>G synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.82 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9197 c.1896G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.83 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9266 p.Asp655Glu missense_variant 0.82 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.82 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 9288 p.Val663Met missense_variant 0.79 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9318 c.2017C>T synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9330 p.Asn677Leu missense_variant 0.61 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCA frameshift_variant&missense_variant 0.59 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9590 c.2289T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9597 c.2296T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9602 c.2301T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9617 c.2316C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9623 c.2322G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9626 c.2325T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9629 c.2328C>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9630 p.Val777Ile missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9647 c.2346C>A synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9668 c.2367C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9674 c.2373T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9683 c.2382G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9686 c.2385A>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9704 c.2403T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9716 c.2415T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9717 c.2416C>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9738 c.2437_2439delTTGinsAA frameshift_variant&missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 9743 c.2442C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
fgd1 491043 c.261T>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491067 c.285C>T synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491082 c.300T>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491085 c.303T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491088 c.306C>T synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491133 c.351A>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491135 p.Tyr118Phe missense_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Thr missense_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491143 p.Ala121Gln missense_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491220 c.438C>T synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491223 c.441C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fgd1 491226 c.444C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491229 c.447C>T synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.82 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.82 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.79 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491307 c.525C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491328 c.546C>A synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fgd1 491355 c.573C>T synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491364 c.582T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491367 c.585G>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491382 c.600G>A synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491409 c.627G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fgd1 491415 c.633A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491417 p.Arg212Leu missense_variant 0.67 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491420 p.Glu213Ala missense_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491429 p.Ala216Glu missense_variant 0.65 clofazimine
pretomanid
delamanid
fgd1 491436 c.654T>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fgd1 491439 p.Asp219Glu missense_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491442 c.660A>G synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491443 p.Ser221Asp missense_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491447 p.Val222Ala missense_variant 0.65 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491490 c.708C>T synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491539 c.757_759delTCGinsAGC synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_782delAGinsTC synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575659 c.312A>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.46 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.66 ethionamide
isoniazid
mshA 575692 c.345G>C synonymous_variant 0.66 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.65 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.65 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.65 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575714 p.Tyr123Asn missense_variant 0.69 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.68 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.75 ethionamide
isoniazid
mshA 575740 c.393G>C synonymous_variant 0.78 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.83 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.83 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.83 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.83 ethionamide
isoniazid Not assoc w R - Interim
mshA 575818 c.471G>C synonymous_variant 0.81 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.8 ethionamide
isoniazid
mshA 575840 c.494dupC frameshift_variant 0.8 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575844 c.498delC frameshift_variant 0.81 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575864 c.517T>C synonymous_variant 0.86 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.87 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.85 ethionamide
isoniazid
mshA 575892 p.Ala182Gly missense_variant 0.83 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.83 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.81 ethionamide
isoniazid
mshA 575908 c.561A>C synonymous_variant 0.8 ethionamide
isoniazid Not assoc w R - Interim
mshA 575916 p.Asp190Ala missense_variant 0.78 ethionamide
isoniazid
mshA 575920 c.573C>T synonymous_variant 0.77 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575925 p.Gly193Ala missense_variant 0.75 ethionamide
isoniazid
mshA 575929 c.582C>G synonymous_variant 0.76 ethionamide
isoniazid
mshA 575932 c.585G>A synonymous_variant 0.75 ethionamide
isoniazid
mshA 575935 c.588G>A synonymous_variant 0.74 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.73 ethionamide
isoniazid
mshA 575953 c.606G>T synonymous_variant 0.71 ethionamide
isoniazid
mshA 575959 c.612G>A synonymous_variant 0.72 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.56 ethionamide
isoniazid
mshA 575983 c.636G>A synonymous_variant 0.51 ethionamide
isoniazid
mshA 576004 c.657T>C synonymous_variant 0.2 ethionamide
isoniazid
ccsA 620569 c.679_681delGGAinsCC frameshift_variant&missense_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620577 c.687C>T synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620586 c.696C>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620592 c.702C>T synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>A synonymous_variant 0.43 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>C synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>A synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620648 p.Glu253Gly missense_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620670 c.780C>A synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
Rv0565c 656031 c.1438_1440delGCAinsTG frameshift_variant&missense_variant 0.28 ethionamide Uncertain significance
Rv0565c 656043 c.1428C>G synonymous_variant 0.27 ethionamide
Rv0565c 656052 c.1419A>C synonymous_variant 0.35 ethionamide
Rv0565c 656061 c.1408_1410delATCinsCG frameshift_variant&missense_variant 0.36 ethionamide Uncertain significance
Rv0565c 656064 c.1407C>G synonymous_variant 0.35 ethionamide
Rv0565c 656073 p.Leu466Phe missense_variant 0.36 ethionamide
Rv0565c 656085 c.1386A>G synonymous_variant 0.35 ethionamide
Rv0565c 656088 c.1383A>G synonymous_variant 0.34 ethionamide
Rv0565c 656091 c.1380T>C synonymous_variant 0.34 ethionamide
Rv0565c 656097 c.1374G>C synonymous_variant 0.35 ethionamide
Rv0565c 656129 p.Tyr448His missense_variant 0.33 ethionamide
Rv0565c 656131 p.Pro447Leu missense_variant 0.33 ethionamide
Rv0565c 656133 c.1338G>A synonymous_variant 0.34 ethionamide
Rv0565c 656140 p.Lys444Leu missense_variant 0.33 ethionamide
Rv0565c 656145 c.1326T>C synonymous_variant 0.33 ethionamide
Rv0565c 656154 c.1317G>A synonymous_variant 0.33 ethionamide Not assoc w R - Interim
Rv0565c 656160 c.1311C>T synonymous_variant 0.31 ethionamide
Rv0565c 656168 p.Ser435Ala missense_variant 0.23 ethionamide Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.37 ethionamide
Rv0565c 657708 c.-238C>A upstream_gene_variant 0.49 ethionamide
Rv0565c 657724 c.-254A>C upstream_gene_variant 0.49 ethionamide
Rv0565c 657732 c.-263_-262delAGinsGA upstream_gene_variant 0.49 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.51 ethionamide
hadA 731723 c.-207T>C upstream_gene_variant 0.2 isoniazid
hadA 731729 c.-201C>T upstream_gene_variant 0.25 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.3 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.28 isoniazid
hadA 731756 c.-174C>T upstream_gene_variant 0.29 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.3 isoniazid
hadA 731795 c.-135C>T upstream_gene_variant 0.26 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.3 isoniazid
hadA 731814 c.-116C>A upstream_gene_variant 0.3 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.27 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.27 isoniazid
hadA 731859 c.-71_-69delGCGinsTT upstream_gene_variant 0.22 isoniazid
nusG 734370 c.117A>G synonymous_variant 0.44 rifampicin
nusG 734373 c.120G>C synonymous_variant 0.48 rifampicin
nusG 734384 p.Ser44Thr missense_variant 0.54 rifampicin
nusG 734391 c.138C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
nusG 734397 c.144C>T synonymous_variant 0.65 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.66 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.71 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.72 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.77 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.81 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.82 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.83 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.88 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.85 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.83 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.78 rifampicin
nusG 734607 c.354C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
nusG 734614 p.Ala121Ser missense_variant 0.73 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.69 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.65 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.58 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.48 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.36 rifampicin Uncertain significance
nusG 734799 c.546G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
nusG 734814 c.561G>C synonymous_variant 0.61 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.7 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.69 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.72 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.73 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.72 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.69 rifampicin
nusG 734889 c.636G>A synonymous_variant 0.68 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.68 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.67 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.7 rifampicin
nusG 734931 c.678A>G synonymous_variant 0.7 rifampicin
nusG 734934 c.681G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
nusG 734950 p.Gly233Asn missense_variant 0.49 rifampicin
nusG 734955 c.702A>G synonymous_variant 0.5 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.57 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>G synonymous_variant 0.61 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.66 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.68 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.68 rifampicin
rpoB 760155 p.Lys117Arg missense_variant 0.67 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.73 rifampicin
rpoB 760178 c.372G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>G synonymous_variant 0.74 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760187 c.381G>A synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.77 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.75 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.75 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.74 rifampicin
rpoB 760323 c.517C>T synonymous_variant 0.74 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.74 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.74 rifampicin
rpoB 760354 p.Glu183Ala missense_variant 0.69 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.68 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.74 rifampicin Uncertain significance
rpoB 760389 c.583_585delAGCinsTCG synonymous_variant 0.69 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.69 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760449 p.Thr215Leu missense_variant 0.71 rifampicin
rpoB 760460 c.654G>T synonymous_variant 0.72 rifampicin
rpoB 760463 c.657C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>T synonymous_variant 0.72 rifampicin Not assoc w R
rpoB 760514 c.708C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760532 c.726T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Arg missense_variant 0.76 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760556 p.Glu250Asp missense_variant 0.79 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.79 rifampicin Uncertain significance
rpoB 760587 p.Thr261Ala missense_variant 0.8 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.79 rifampicin
rpoB 760593 p.Gly263Asn missense_variant 0.79 rifampicin
rpoB 760596 p.Thr264Ser missense_variant 0.8 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.78 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.71 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.43 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.39 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760734 p.Val310Ile missense_variant 0.36 rifampicin
rpoB 760880 c.1074G>C synonymous_variant 0.33 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.33 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.33 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.33 rifampicin Uncertain significance
rpoB 760916 c.1110C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.66 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.67 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.69 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.71 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.8 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.86 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.86 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.86 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.86 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.9 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.9 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.91 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.89 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.89 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.89 rifampicin
rpoB 761306 c.1500C>G synonymous_variant 0.83 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>C synonymous_variant 0.8 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.76 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.75 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761373 p.Val523His missense_variant 0.71 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.59 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.26 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.33 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.69 rifampicin
rpoB 761502 c.1696_1698delCCCinsTG frameshift_variant&missense_variant 0.7 rifampicin
rpoB 761508 c.1702_1704delTCTinsGC frameshift_variant&missense_variant 0.72 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.79 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.87 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.91 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.88 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.88 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.85 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.84 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.8 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.75 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.74 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.68 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsAG frameshift_variant&missense_variant 0.68 rifampicin
rpoB 761728 p.Ser641Thr missense_variant 0.68 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.64 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.54 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.53 rifampicin
rpoB 761777 c.1971C>T synonymous_variant 0.55 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.56 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.64 rifampicin
rpoB 761798 c.1992C>T synonymous_variant 0.65 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.68 rifampicin
rpoB 761814 p.Ala670Asn missense_variant 0.68 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.69 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.72 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.72 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.75 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.76 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.79 rifampicin
rpoB 761881 p.Ala692Val missense_variant 0.8 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.81 rifampicin
rpoB 761897 c.2091C>G synonymous_variant 0.81 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.8 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.81 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.8 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.82 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.83 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.84 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAG frameshift_variant&missense_variant 0.88 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.86 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.89 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.9 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.89 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.89 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.88 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.88 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>T synonymous_variant 0.89 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.9 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.88 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.88 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.91 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.91 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.91 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.91 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.9 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.89 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.89 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.89 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.9 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Ala missense_variant 0.86 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.8 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.8 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.8 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.78 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.78 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.78 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.79 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.56 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.56 rifampicin
rpoB 762599 c.2793T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762728 c.-642C>G upstream_gene_variant 0.39 rifampicin
rpoB 762735 p.Ala977Asn missense_variant 0.48 rifampicin
rpoB 762749 c.2943C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.57 rifampicin
rpoB 762760 p.Cys985Ser missense_variant 0.58 rifampicin Uncertain significance
rpoB 762768 p.Pro988Ala missense_variant 0.69 rifampicin Uncertain significance
rpoB 762782 c.2976T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.73 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.74 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.78 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762814 p.Met1003Arg missense_variant 0.81 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.91 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.92 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.91 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763079 c.-291C>T upstream_gene_variant 0.9 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.89 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.87 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.82 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.81 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.82 rifampicin Uncertain significance
rpoB 763214 c.3408T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763227 c.3421C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763262 c.-108C>A upstream_gene_variant 0.69 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.68 rifampicin
rpoC 763268 c.-102C>A upstream_gene_variant 0.67 rifampicin
rpoB 763283 c.3477T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763351 c.-19T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoC 763396 c.27A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.82 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.82 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.86 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.83 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.83 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.81 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.77 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.79 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.77 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.68 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.64 rifampicin
rpoC 763790 p.Glu141Thr missense_variant 0.57 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.46 rifampicin
rpoC 763822 c.453C>G synonymous_variant 0.28 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763867 c.498C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763872 p.Gly168Ala missense_variant 0.24 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.35 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.41 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.4 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.4 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.4 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.5 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.53 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.57 rifampicin Uncertain significance
rpoC 763966 c.597C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.73 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.73 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.73 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.72 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.72 rifampicin
rpoC 764030 p.Asp221Asn missense_variant 0.72 rifampicin Uncertain significance
rpoC 764039 p.Ser224Asp missense_variant 0.74 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.74 rifampicin
rpoC 764048 p.Thr227Val missense_variant 0.74 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.78 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.73 rifampicin
rpoC 764085 p.Asn239Thr missense_variant 0.73 rifampicin Uncertain significance
rpoC 764087 p.Leu240Val missense_variant 0.74 rifampicin Uncertain significance
rpoC 764098 c.729A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764134 c.765C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764169 p.Asn267Thr missense_variant 0.81 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.8 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Thr missense_variant 0.81 rifampicin Uncertain significance
rpoC 764213 p.Arg282Lys missense_variant 0.81 rifampicin Uncertain significance
rpoC 764248 c.879C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764255 c.886C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764272 c.903G>C synonymous_variant 0.87 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.83 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.82 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.85 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.83 rifampicin
rpoC 764429 c.1060C>T synonymous_variant 0.83 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.81 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.83 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.82 rifampicin
rpoC 764452 c.1083T>G synonymous_variant 0.82 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.85 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.85 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.85 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.87 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.88 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.87 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.88 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>G synonymous_variant 0.88 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.89 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.87 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.87 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.84 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.79 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.78 rifampicin
rpoC 765076 c.1707A>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.74 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.75 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765121 c.1752G>C synonymous_variant 0.64 rifampicin
rpoC 765202 c.1833C>G synonymous_variant 0.24 rifampicin
rpoC 765208 c.1839T>C synonymous_variant 0.47 rifampicin
rpoC 765220 c.1851A>G synonymous_variant 0.56 rifampicin
rpoC 765232 c.1863G>C synonymous_variant 0.59 rifampicin
rpoC 765234 p.Ala622Val missense_variant 0.59 rifampicin
rpoC 765277 c.1908G>T synonymous_variant 0.66 rifampicin
rpoC 765281 p.Thr638Asp missense_variant 0.66 rifampicin Uncertain significance
rpoC 765300 p.Val644Ala missense_variant 0.75 rifampicin Uncertain significance
rpoC 765305 p.Ile646Val missense_variant 0.75 rifampicin Uncertain significance
rpoC 765311 p.Ala648Thr missense_variant 0.77 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.79 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.8 rifampicin Uncertain significance
rpoC 765339 p.Gln657Arg missense_variant 0.83 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765403 c.2034G>C synonymous_variant 0.84 rifampicin
rpoC 765404 p.Leu679Thr missense_variant 0.83 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765418 c.2049C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.84 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.81 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.82 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.82 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.84 rifampicin
rpoC 765607 c.2238C>G synonymous_variant 0.83 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.81 rifampicin Uncertain significance
rpoC 765628 c.2259G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.79 rifampicin
rpoC 765673 p.Asp768Glu missense_variant 0.79 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765718 p.Asp783Glu missense_variant 0.82 rifampicin Uncertain significance
rpoC 765721 c.2352G>A synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.8 rifampicin
rpoC 765742 p.Glu791Asp missense_variant 0.79 rifampicin Uncertain significance
rpoC 765787 c.2418C>T synonymous_variant 0.79 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.79 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.79 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.82 rifampicin Uncertain significance
rpoC 765904 c.2535C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.87 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Gly missense_variant 0.63 rifampicin
rpoC 766061 c.2692_2694delGTCinsAG frameshift_variant&missense_variant 0.53 rifampicin
rpoC 766066 c.2697C>G synonymous_variant 0.54 rifampicin
rpoC 766270 c.2901G>C synonymous_variant 0.53 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.57 rifampicin
rpoC 766294 c.2925C>T synonymous_variant 0.61 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.61 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.62 rifampicin
rpoC 766306 c.2937C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766309 c.2940G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.66 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.7 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.78 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.81 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.82 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.83 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.84 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.86 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.87 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.87 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.87 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.86 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.83 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.83 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.86 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.83 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.84 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.83 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.83 rifampicin
rpoC 766537 c.3168G>A synonymous_variant 0.82 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.83 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.83 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.83 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.83 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766576 c.3207C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.84 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.86 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.86 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.87 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.89 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.88 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.87 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.87 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.88 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.86 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.86 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.9 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.9 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.89 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766726 c.3357T>C synonymous_variant 0.89 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.88 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.87 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.87 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.85 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.85 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.86 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.82 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.78 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.77 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.77 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.77 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.77 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.78 rifampicin
rpoC 766918 c.3549C>A synonymous_variant 0.77 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.77 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.78 rifampicin
rpoC 766935 p.Glu1189Ala missense_variant 0.78 rifampicin
rpoC 766942 c.3573C>G synonymous_variant 0.78 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>G synonymous_variant 0.75 rifampicin
rpoC 766961 p.Gly1198Leu missense_variant 0.75 rifampicin
rpoC 766975 c.3606C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.86 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>G synonymous_variant 0.88 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767191 c.3822C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767278 c.3909T>C synonymous_variant 0.66 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775817 c.2664T>C synonymous_variant 0.48 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775826 c.2655G>C synonymous_variant 0.44 clofazimine
bedaquiline
mmpL5 775829 c.2652C>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 775832 c.2649C>G synonymous_variant 0.54 clofazimine
bedaquiline
mmpL5 775838 c.2643G>C synonymous_variant 0.42 clofazimine
bedaquiline
mmpL5 775844 c.2637G>A synonymous_variant 0.44 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.53 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.48 clofazimine
bedaquiline
mmpL5 775871 p.Ile870Met missense_variant 0.4 clofazimine
bedaquiline
mmpL5 775882 p.Asn867His missense_variant 0.42 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsCG frameshift_variant&missense_variant 0.42 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>G synonymous_variant 0.58 clofazimine
bedaquiline
mmpL5 775905 p.Lys859Arg missense_variant 0.39 clofazimine
bedaquiline
mmpL5 775907 c.2574C>G synonymous_variant 0.55 clofazimine
bedaquiline
mmpL5 775910 c.2571G>C synonymous_variant 0.68 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.75 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775937 c.2542_2544delGCGinsTC frameshift_variant&missense_variant 0.39 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775940 c.2541C>T synonymous_variant 0.39 clofazimine
bedaquiline
mmpL5 775943 c.2538C>G synonymous_variant 0.58 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.74 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.64 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.6 clofazimine
bedaquiline
mmpL5 775970 c.2511G>C synonymous_variant 0.48 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.64 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.57 clofazimine
bedaquiline
mmpL5 775990 p.Leu831Val missense_variant 0.18 clofazimine
bedaquiline
mmpL5 775993 p.Glu830Gln missense_variant 0.3 clofazimine
bedaquiline
mmpL5 775994 c.2487C>T synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.26 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776017 p.Ile822Val missense_variant 0.26 clofazimine
bedaquiline
mmpL5 776039 c.2442C>G synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.61 streptomycin
rpsL 781592 c.33T>C synonymous_variant 0.65 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.65 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.64 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.62 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.61 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.68 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.71 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.76 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.76 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.81 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.85 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.84 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.85 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.84 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.85 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.84 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.86 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.86 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.86 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.88 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.88 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.89 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.89 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.87 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.88 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.89 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.85 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.84 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.84 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.85 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.86 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.86 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.84 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.81 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.79 streptomycin Uncertain significance
rplC 800480 c.-329G>T upstream_gene_variant 0.32 linezolid
rplC 800498 c.-311G>A upstream_gene_variant 0.52 linezolid
rplC 800516 c.-293G>C upstream_gene_variant 0.57 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.71 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.72 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.74 linezolid
rplC 800574 c.-235_-233delGTCinsACT upstream_gene_variant 0.75 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.8 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.81 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.83 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.84 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.85 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.84 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.84 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.84 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.77 linezolid
rplC 800699 c.-110G>A upstream_gene_variant 0.76 linezolid
rplC 800700 c.-109C>A upstream_gene_variant 0.74 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.75 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.74 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.67 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.65 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.59 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.58 linezolid
rplC 800838 c.30G>A synonymous_variant 0.41 linezolid
rplC 800844 c.36T>C synonymous_variant 0.48 linezolid
rplC 800856 c.48A>G synonymous_variant 0.55 linezolid
rplC 800865 c.57A>G synonymous_variant 0.56 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.56 linezolid
rplC 800873 p.Arg22Lys missense_variant 0.56 linezolid
rplC 800877 c.69A>C synonymous_variant 0.55 linezolid
rplC 800880 c.72A>G synonymous_variant 0.55 linezolid
rplC 800886 c.78G>C synonymous_variant 0.56 linezolid
rplC 800889 c.81C>G synonymous_variant 0.56 linezolid
rplC 800892 c.84G>C synonymous_variant 0.6 linezolid
rplC 800916 c.108A>G synonymous_variant 0.67 linezolid
rplC 800931 c.123G>C synonymous_variant 0.67 linezolid
rplC 800937 c.129A>G synonymous_variant 0.67 linezolid
rplC 800946 c.138T>C synonymous_variant 0.67 linezolid
rplC 800949 c.141T>C synonymous_variant 0.67 linezolid
rplC 800950 c.142_143delAGinsTC synonymous_variant 0.67 linezolid
rplC 800964 c.156G>C synonymous_variant 0.69 linezolid
rplC 800967 c.159C>T synonymous_variant 0.7 linezolid
rplC 800970 c.162T>C synonymous_variant 0.69 linezolid Not assoc w R - Interim
rplC 800985 c.177A>T synonymous_variant 0.67 linezolid
rplC 801009 c.201A>C synonymous_variant 0.57 linezolid
rplC 801019 c.211_213delACCinsGG frameshift_variant&missense_variant 0.57 linezolid
rplC 801030 c.222C>G synonymous_variant 0.56 linezolid
rplC 801039 c.231A>G synonymous_variant 0.55 linezolid
rplC 801045 c.237A>G synonymous_variant 0.45 linezolid
rplC 801046 p.Tyr80His missense_variant 0.41 linezolid
rplC 801052 c.244_246delGCGinsAC frameshift_variant&missense_variant 0.32 linezolid
rplC 801063 c.255G>C synonymous_variant 0.3 linezolid
rplC 801066 c.258G>T synonymous_variant 0.28 linezolid
rplC 801105 c.297A>G synonymous_variant 0.3 linezolid
rplC 801109 c.301T>C synonymous_variant 0.41 linezolid Not assoc w R - Interim
rplC 801117 c.309G>C synonymous_variant 0.55 linezolid
rplC 801132 c.324T>C synonymous_variant 0.59 linezolid
rplC 801136 p.Ser110Ala missense_variant 0.58 linezolid
rplC 801147 c.339T>C synonymous_variant 0.59 linezolid
rplC 801153 c.345G>C synonymous_variant 0.58 linezolid
rplC 801156 c.348T>C synonymous_variant 0.63 linezolid
rplC 801171 c.363A>G synonymous_variant 0.67 linezolid
rplC 801174 c.366T>C synonymous_variant 0.67 linezolid
rplC 801176 p.Phe123Tyr missense_variant 0.68 linezolid
rplC 801210 c.402T>C synonymous_variant 0.75 linezolid
rplC 801220 p.Ser138Gly missense_variant 0.78 linezolid
rplC 801228 c.420T>C synonymous_variant 0.78 linezolid
rplC 801231 c.423C>G synonymous_variant 0.8 linezolid
rplC 801237 c.429G>A synonymous_variant 0.78 linezolid
rplC 801249 c.441T>G synonymous_variant 0.79 linezolid
rplC 801255 c.447C>T synonymous_variant 0.75 linezolid
rplC 801258 c.450C>G synonymous_variant 0.73 linezolid
rplC 801267 c.459A>C synonymous_variant 0.65 linezolid
rplC 801270 c.462T>C synonymous_variant 0.61 linezolid
rplC 801271 c.463_465delGCCinsTG frameshift_variant&missense_variant 0.61 linezolid
rplC 801276 c.468G>C synonymous_variant 0.61 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.61 linezolid
rplC 801307 c.499_501delGCCinsTA frameshift_variant&missense_variant 0.51 linezolid
rplC 801312 c.504G>C synonymous_variant 0.48 linezolid
rplC 801324 c.516T>C synonymous_variant 0.47 linezolid
rplC 801330 c.522G>C synonymous_variant 0.35 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303418 p.Gly163Asp missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303422 c.492A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303431 c.501T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303435 c.505_506delTCinsAG synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303441 c.511T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303444 p.Ser172Ala missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303449 c.519C>T synonymous_variant 0.43 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303455 c.525C>G synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303583 p.Thr218Ser missense_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303620 c.690C>T synonymous_variant 0.61 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303632 c.702T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304798 p.Ala623Glu missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.52 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304845 p.Ala639Thr missense_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>G synonymous_variant 0.64 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304857 p.Thr643Ser missense_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304868 c.1938G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304874 c.1944C>T synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304915 p.Asp662Gly missense_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304918 p.Thr663Ser missense_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305259 c.2329T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1305339 c.2409C>A synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305345 c.2415C>T synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305348 c.2418C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1305360 c.2430G>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.5 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305418 p.Val830Ile missense_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1305427 c.2497C>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305434 p.Ala835Gly missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305444 c.2514A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305452 p.Gly841Asp missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305462 c.2532G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
sigE 1364820 c.408A>G synonymous_variant 0.49 pyrazinamide
sigE 1364826 c.414C>G synonymous_variant 0.54 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.41 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.39 pyrazinamide
sigE 1364860 c.448_450delCGCinsAG frameshift_variant&missense_variant 0.39 pyrazinamide Uncertain significance
sigE 1364865 c.453G>T synonymous_variant 0.39 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.38 pyrazinamide
sigE 1364871 c.459C>G synonymous_variant 0.42 pyrazinamide
sigE 1364872 c.460_462delATCinsGG frameshift_variant&missense_variant 0.42 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.49 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.67 pyrazinamide
sigE 1364910 c.498G>C synonymous_variant 0.71 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.72 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.75 pyrazinamide
sigE 1364926 p.Asn172Asp missense_variant 0.78 pyrazinamide
sigE 1364940 c.528C>T synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
sigE 1364960 p.Gly183Asp missense_variant 0.77 pyrazinamide
sigE 1364976 c.564T>G synonymous_variant 0.75 pyrazinamide
sigE 1364979 c.567C>T synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
sigE 1364980 c.568T>C synonymous_variant 0.74 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.74 pyrazinamide
sigE 1364989 c.577C>T synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
sigE 1364992 c.580_582delCCGinsGC frameshift_variant&missense_variant 0.76 pyrazinamide Uncertain significance
sigE 1365003 c.591T>C synonymous_variant 0.74 pyrazinamide
sigE 1365006 c.594T>G synonymous_variant 0.74 pyrazinamide
sigE 1365009 c.597C>G synonymous_variant 0.74 pyrazinamide
sigE 1365012 c.600G>C synonymous_variant 0.74 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.71 pyrazinamide
sigE 1365036 c.624T>G synonymous_variant 0.71 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.68 pyrazinamide
sigE 1365048 c.636G>A synonymous_variant 0.64 pyrazinamide
sigE 1365052 p.Ile214Val missense_variant 0.62 pyrazinamide Uncertain significance
sigE 1365063 c.651A>C synonymous_variant 0.56 pyrazinamide
sigE 1365069 c.657C>G synonymous_variant 0.46 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461083 c.39T>C synonymous_variant 0.24 bedaquiline
atpE 1461086 c.42A>T synonymous_variant 0.26 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.31 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.38 bedaquiline
atpE 1461132 c.88_90delGTCinsAT frameshift_variant&missense_variant 0.52 bedaquiline
atpE 1461147 c.103_105delCTTinsTG frameshift_variant&missense_variant 0.53 bedaquiline
atpE 1461153 p.Ser37Ala missense_variant 0.53 bedaquiline Uncertain significance
atpE 1461159 p.Val39Ile missense_variant 0.51 bedaquiline Uncertain significance
atpE 1461164 c.120C>T synonymous_variant 0.5 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.48 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.48 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.48 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.49 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.5 bedaquiline
atpE 1461215 c.171C>T synonymous_variant 0.52 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.5 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.42 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.24 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472302 n.457_458insT non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472310 n.465_466insG non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473939 n.282C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1473964 n.307T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473965 n.308G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473985 n.328A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474016 n.359C>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474026 n.369C>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474105 n.448delTinsCG non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474116 n.459G>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1474287 n.630_647delTCCTTTTCCTCTCCGGAGinsCTCTCTTT non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474415 n.760_765delACACGC non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474426 n.769T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474428 n.771C>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474430 n.773C>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474432 n.775C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474438 n.781delAinsGT non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475239 n.1582_1583delACinsTGGCAG non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475241 n.1584C>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475246 n.1589_1590insT non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475249 n.1594_1598delACTCC non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475265 n.1608_1611delGTGTinsTGA non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475272 n.1615G>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475278 n.1621delGinsCC non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475378 n.1721A>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475379 n.1722G>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475396 n.1739_1740insTG non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475399 n.1742T>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475400 n.1743C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid Uncertain significance
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475408 n.1752delT non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475428 n.1771G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475433 n.1776A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476746 n.3089T>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476748 n.3091A>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476753 n.3096T>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476755 n.3098G>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
inhA 1673646 c.-556T>C upstream_gene_variant 0.5 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.53 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.52 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.53 ethionamide
isoniazid
inhA 1673679 c.-523T>A upstream_gene_variant 0.61 ethionamide
isoniazid
inhA 1673682 c.-520G>C upstream_gene_variant 0.64 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673698 p.Ser87Ala missense_variant 0.66 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.66 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.64 ethionamide
isoniazid
inhA 1673724 c.-478A>G upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1673730 c.-472C>G upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.63 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.63 ethionamide
isoniazid
inhA 1673757 c.-445G>A upstream_gene_variant 0.64 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.64 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.65 ethionamide
isoniazid
inhA 1673787 c.-415G>C upstream_gene_variant 0.65 ethionamide
isoniazid
fabG1 1673797 c.358_360delGCTinsAC frameshift_variant&missense_variant 0.61 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.59 ethionamide
isoniazid
inhA 1673805 c.-397G>C upstream_gene_variant 0.59 ethionamide
isoniazid
inhA 1673808 c.-394A>G upstream_gene_variant 0.6 ethionamide
isoniazid
inhA 1673811 c.-391G>A upstream_gene_variant 0.58 ethionamide
isoniazid
fabG1 1673829 p.Asn130Lys missense_variant 0.32 ethionamide
isoniazid
fabG1 1673830 p.Lys131Arg missense_variant 0.28 ethionamide
isoniazid
inhA 1673838 c.-364T>C upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1673841 c.-361A>G upstream_gene_variant 0.28 ethionamide
isoniazid
fabG1 1673844 p.Met135Ile missense_variant 0.28 ethionamide
isoniazid
fabG1 1673849 p.Phe137Tyr missense_variant 0.29 ethionamide
isoniazid
inhA 1673853 c.-349A>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673856 c.-346T>A upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673865 c.-337C>G upstream_gene_variant 0.31 ethionamide
isoniazid
fabG1 1673870 p.Ser144Met missense_variant 0.31 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.3 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.26 ethionamide
isoniazid
inhA 1674327 c.126C>T synonymous_variant 0.3 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674342 c.141T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674353 p.Thr51Ile missense_variant 0.32 ethionamide
isoniazid
inhA 1674375 c.174C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674387 c.186A>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674399 c.198A>G synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674403 p.Glu68Thr missense_variant 0.42 ethionamide
isoniazid
inhA 1674414 c.213G>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674416 p.Ala72Asp missense_variant 0.41 ethionamide
isoniazid
inhA 1674419 p.Ser73Thr missense_variant 0.4 ethionamide
isoniazid
inhA 1674421 c.220T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674428 p.Gly76Asp missense_variant 0.5 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674433 c.232_234delGTGinsAC frameshift_variant&missense_variant 0.5 ethionamide
isoniazid
inhA 1674443 p.Ala81Val missense_variant 0.52 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.55 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.57 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674507 c.306G>A synonymous_variant 0.69 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.74 ethionamide
isoniazid
inhA 1674534 c.333G>T synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.75 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.74 ethionamide
isoniazid
inhA 1674570 c.369G>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.77 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.74 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.73 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.72 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.73 ethionamide
isoniazid
inhA 1674615 p.Met138Ile missense_variant 0.73 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.72 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.72 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.72 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.72 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.73 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.75 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 0.74 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.76 ethionamide
isoniazid
inhA 1674735 c.534G>A synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674742 p.Lys181Pro missense_variant 0.75 ethionamide
isoniazid
inhA 1674745 p.Tyr182His missense_variant 0.74 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674750 c.549T>C synonymous_variant 0.75 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.79 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674830 p.Glu210Gly missense_variant 0.67 ethionamide
isoniazid
inhA 1674837 c.636C>T synonymous_variant 0.65 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674839 p.Ala213Glu missense_variant 0.66 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.67 ethionamide
isoniazid Uncertain significance
inhA 1674870 c.669T>C synonymous_variant 0.72 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.72 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674892 p.Asn231Asp missense_variant 0.73 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.65 ethionamide
isoniazid
inhA 1674907 c.706_708delACGinsGC frameshift_variant&missense_variant 0.65 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.64 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.64 ethionamide
isoniazid
inhA 1674927 c.726G>C synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674933 c.732G>A synonymous_variant 0.68 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674942 c.741T>G synonymous_variant 0.65 ethionamide
isoniazid
inhA 1674945 c.744C>T synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674963 c.762G>C synonymous_variant 0.48 ethionamide
isoniazid
inhA 1674965 c.765_767delTGA disruptive_inframe_deletion 0.47 ethionamide
isoniazid
inhA 1674970 c.769_770insCGG disruptive_inframe_insertion 0.47 ethionamide
isoniazid
inhA 1674973 p.Ile258Val missense_variant 0.48 ethionamide
isoniazid
inhA 1674993 c.792G>C synonymous_variant 0.45 ethionamide
isoniazid
rpsA 1833540 c.-2_-1delATinsC upstream_gene_variant 0.55 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.67 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.78 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.76 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.77 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.77 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.78 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.79 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
rpsA 1833664 c.123C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.89 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.88 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.87 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.89 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.88 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.9 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.91 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.88 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.86 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.87 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.86